SIMILAR PATTERNS OF AMINO ACIDS FOR 6FGD_A_ACTA821_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e5f METHIONINE
GAMMA-LYASE

(Trichomonas
vaginalis) 		PF01053
(Cys_Met_Meta_PP) 		3 ARG A  46
PHE A  47
GLY A  43
 None
 0.71A 6fgdA-1e5fA:
0.0		 6fgdA-1e5fA:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fbw ENDO-1,4-BETA-GLUCAN
ASE F

([Clostridium]
cellulolyticum) 		PF02011
(Glyco_hydro_48) 		3 ARG A 133
PHE A 276
GLY A 288
 None
 0.67A 6fgdA-1fbwA:
0.0		 6fgdA-1fbwA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fp9 4-ALPHA-GLUCANOTRANS
FERASE

(Thermus
thermophilus) 		PF02446
(Glyco_hydro_77) 		3 ARG A 296
PHE A 295
GLY A 297
 None
 0.82A 6fgdA-1fp9A:
0.0		 6fgdA-1fp9A:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fw8 PHOSPHOGLYCERATE
KINASE

(Saccharomyces
cerevisiae) 		PF00162
(PGK) 		3 ARG A 247
PHE A 250
GLY A 277
 None
 0.70A 6fgdA-1fw8A:
2.6		 6fgdA-1fw8A:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gey HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE

(Escherichia
coli) 		PF00155
(Aminotran_1_2) 		3 ARG A 303
PHE A 304
GLY A 332
 None
 0.80A 6fgdA-1geyA:
1.2		 6fgdA-1geyA:
24.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i2m REGULATOR OF
CHROMOSOME
CONDENSATION 1

(Homo sapiens) 		PF00415
(RCC1) 		3 ARG B 241
PHE B 242
GLY B 191
 None
 0.79A 6fgdA-1i2mB:
0.0		 6fgdA-1i2mB:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kfw CHITINASE B

(Arthrobacter
sp. TAD20) 		PF00704
(Glyco_hydro_18) 		3 ARG A 174
PHE A 171
GLY A 173
 None
 0.78A 6fgdA-1kfwA:
undetectable		 6fgdA-1kfwA:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mdf 2,3-DIHYDROXYBENZOAT
E-AMP LIGASE

(Bacillus
subtilis) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		3 ARG A  97
PHE A  96
GLY A  28
 None
 0.76A 6fgdA-1mdfA:
3.3		 6fgdA-1mdfA:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1soi MUTT/NUDIX FAMILY
PROTEIN

(Deinococcus
radiodurans) 		PF00293
(NUDIX) 		3 ARG A  86
PHE A  87
GLY A  90
 SM  A 303 ( 4.7A)
None
SM  A 303 (-4.8A)
 0.76A 6fgdA-1soiA:
undetectable		 6fgdA-1soiA:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tz7 4-ALPHA-GLUCANOTRANS
FERASE

(Aquifex
aeolicus) 		PF02446
(Glyco_hydro_77) 		3 ARG A 289
PHE A 288
GLY A 290
 None
 0.63A 6fgdA-1tz7A:
undetectable		 6fgdA-1tz7A:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uus STAT PROTEIN

(Dictyostelium
discoideum) 		PF00017
(SH2)
PF09267
(Dict-STAT-coil) 		3 ARG A 551
PHE A 548
GLY A 549
 None
 0.74A 6fgdA-1uusA:
undetectable		 6fgdA-1uusA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v77 HYPOTHETICAL PROTEIN
PH1877

(Pyrococcus
horikoshii) 		PF01876
(RNase_P_p30) 		3 ARG A 107
PHE A 148
GLY A 111
 None
 0.80A 6fgdA-1v77A:
undetectable		 6fgdA-1v77A:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wfz NITROGEN FIXATION
CLUSTER-LIKE

(Mus musculus) 		PF01592
(NifU_N) 		3 ARG A  53
PHE A  54
GLY A  14
 None
 0.65A 6fgdA-1wfzA:
undetectable		 6fgdA-1wfzA:
16.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x1n 4-ALPHA-GLUCANOTRANS
FERASE

(Solanum
tuberosum) 		PF02446
(Glyco_hydro_77) 		3 ARG A 324
PHE A 323
GLY A 325
 None
 0.71A 6fgdA-1x1nA:
undetectable		 6fgdA-1x1nA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x2b PROLINE
IMINOPEPTIDASE

(Serratia
marcescens) 		PF00561
(Abhydrolase_1) 		3 ARG A 156
PHE A 157
GLY A 153
 None
 0.78A 6fgdA-1x2bA:
2.7		 6fgdA-1x2bA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x2g LIPOATE-PROTEIN
LIGASE A

(Escherichia
coli) 		PF03099
(BPL_LplA_LipB)
PF10437
(Lip_prot_lig_C) 		3 ARG A 258
PHE A 259
GLY A 262
 None
 0.72A 6fgdA-1x2gA:
undetectable		 6fgdA-1x2gA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x49 INTERFERON-INDUCED,
DOUBLE-STRANDED
RNA-ACTIVATED
PROTEIN KINASE

(Mus musculus) 		PF00035
(dsrm) 		3 ARG A  46
PHE A  47
GLY A  63
 None
 0.68A 6fgdA-1x49A:
undetectable		 6fgdA-1x49A:
13.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z24 INSECTICYANIN A FORM

(Manduca sexta) 		PF00061
(Lipocalin) 		3 ARG A 188
PHE A  94
GLY A 185
 None
BLV  A 195 (-4.0A)
None
 0.73A 6fgdA-1z24A:
undetectable		 6fgdA-1z24A:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bka TAT-INTERACTING
PROTEIN TIP30

(Homo sapiens) 		PF13460
(NAD_binding_10) 		3 ARG A  15
PHE A  44
GLY A  42
 None
 0.81A 6fgdA-2bkaA:
4.1		 6fgdA-2bkaA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bvt BETA-1,4-MANNANASE

(Cellulomonas
fimi) 		PF02156
(Glyco_hydro_26) 		3 ARG A 364
PHE A 362
GLY A 360
 None
 0.73A 6fgdA-2bvtA:
undetectable		 6fgdA-2bvtA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ca4 SULFITE:CYTOCHROME C
OXIDOREDUCTASE
SUBUNIT A

(Starkeya
novella) 		PF00174
(Oxidored_molyb)
PF03404
(Mo-co_dimer) 		3 ARG A 260
PHE A 261
GLY A 290
 None
 0.80A 6fgdA-2ca4A:
undetectable		 6fgdA-2ca4A:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cb1 O-ACETYL HOMOSERINE
SULFHYDRYLASE

(Thermus
thermophilus) 		PF01053
(Cys_Met_Meta_PP) 		3 ARG A  41
PHE A  42
GLY A  38
 None
 0.76A 6fgdA-2cb1A:
undetectable		 6fgdA-2cb1A:
25.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2emz ZINC FINGER PROTEIN
95 HOMOLOG

(Homo sapiens) 		PF00096
(zf-C2H2) 		3 ARG A  11
PHE A  13
GLY A  23
 None
 0.78A 6fgdA-2emzA:
undetectable		 6fgdA-2emzA:
8.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ivp O-SIALOGLYCOPROTEIN
ENDOPEPTIDASE

(Pyrococcus
abyssi) 		PF00814
(Peptidase_M22) 		3 ARG A 163
PHE A 169
GLY A  36
 None
 0.78A 6fgdA-2ivpA:
undetectable		 6fgdA-2ivpA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jx8 PHOSPHORYLATED
CTD-INTERACTING
FACTOR 1

(Homo sapiens) 		PF00397
(WW) 		3 ARG A  26
PHE A  27
GLY A   9
 None
 0.69A 6fgdA-2jx8A:
undetectable		 6fgdA-2jx8A:
7.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o0x 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE

(Mycobacterium
tuberculosis) 		PF00275
(EPSP_synthase) 		3 ARG A 100
PHE A 101
GLY A  96
 SKP  A 501 ( 4.7A)
SKP  A 501 (-4.9A)
SKP  A 501 (-3.8A)
 0.64A 6fgdA-2o0xA:
undetectable		 6fgdA-2o0xA:
24.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o2z HYPOTHETICAL PROTEIN

(Bacillus
halodurans) 		PF01933
(UPF0052) 		3 ARG A  78
PHE A  79
GLY A  87
 SO4  A 323 (-2.8A)
None
None
 0.77A 6fgdA-2o2zA:
2.5		 6fgdA-2o2zA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2obv S-ADENOSYLMETHIONINE
SYNTHETASE ISOFORM
TYPE-1

(Homo sapiens) 		PF00438
(S-AdoMet_synt_N)
PF02772
(S-AdoMet_synt_M)
PF02773
(S-AdoMet_synt_C) 		3 ARG A 382
PHE A 380
GLY A 378
 None
 0.78A 6fgdA-2obvA:
undetectable		 6fgdA-2obvA:
24.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qy0 COMPLEMENT C1R
SUBCOMPONENT

(Homo sapiens) 		PF00089
(Trypsin) 		3 ARG B 591
PHE B 592
GLY B 450
 None
 0.76A 6fgdA-2qy0B:
undetectable		 6fgdA-2qy0B:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r8a LONG-CHAIN FATTY
ACID TRANSPORT
PROTEIN

(Escherichia
coli) 		PF03349
(Toluene_X) 		3 ARG A 157
PHE A 158
GLY A 118
 None
 0.78A 6fgdA-2r8aA:
undetectable		 6fgdA-2r8aA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rdy BH0842 PROTEIN

(Bacillus
halodurans) 		PF14498
(Glyco_hyd_65N_2) 		3 ARG A 508
PHE A 509
GLY A 515
 None
 0.69A 6fgdA-2rdyA:
undetectable		 6fgdA-2rdyA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x1i 4-ALPHA-GLUCANOTRANS
FERASE

(Thermus
brockianus) 		PF02446
(Glyco_hydro_77) 		3 ARG A 296
PHE A 295
GLY A 297
 None
 0.76A 6fgdA-2x1iA:
undetectable		 6fgdA-2x1iA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x8x TLR1789 PROTEIN

(Thermosynechococcus
elongatus) 		PF07244
(POTRA)
PF08479
(POTRA_2) 		3 ARG X 299
PHE X 274
GLY X 272
 None
 0.79A 6fgdA-2x8xX:
undetectable		 6fgdA-2x8xX:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xws SIROHYDROCHLORIN
COBALTOCHELATASE

(Archaeoglobus
fulgidus) 		PF01903
(CbiX) 		3 ARG A  46
PHE A  41
GLY A  11
 None
 0.71A 6fgdA-2xwsA:
5.6		 6fgdA-2xwsA:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y7c TYPE-1 RESTRICTION
ENZYME ECOKI
SPECIFICITY PROTEIN

(Escherichia
coli) 		PF01420
(Methylase_S) 		3 ARG A 269
PHE A 270
GLY A 249
 None
 0.77A 6fgdA-2y7cA:
undetectable		 6fgdA-2y7cA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zuk ALPHA-AMINO-EPSILON-
CAPROLACTAM RACEMASE

(Achromobacter
obae) 		PF00202
(Aminotran_3) 		3 ARG A 222
PHE A 258
GLY A 257
 None
 0.81A 6fgdA-2zukA:
undetectable		 6fgdA-2zukA:
24.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dto BH2835 PROTEIN

(Bacillus
halodurans) 		PF01966
(HD) 		3 ARG A 196
PHE A 199
GLY A 128
 None
 0.70A 6fgdA-3dtoA:
undetectable		 6fgdA-3dtoA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ff6 ACETYL-COA
CARBOXYLASE 2

(Homo sapiens) 		PF01039
(Carboxyl_trans) 		3 ARG A1776
PHE A1777
GLY A1785
 None
 0.51A 6fgdA-3ff6A:
undetectable		 6fgdA-3ff6A:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3goa 3-KETOACYL-COA
THIOLASE

(Salmonella
enterica) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		3 ARG A  23
PHE A  22
GLY A  20
 None
 0.77A 6fgdA-3goaA:
undetectable		 6fgdA-3goaA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hi2 HTH-TYPE
TRANSCRIPTIONAL
REGULATOR MQSA(YGIT)

(Escherichia
coli) 		PF15731
(MqsA_antitoxin) 		3 ARG A  25
PHE A  22
GLY A  24
 None
GOL  A3968 (-4.7A)
None
 0.74A 6fgdA-3hi2A:
undetectable		 6fgdA-3hi2A:
11.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i4g SUSD-LIKE
CARBOHYDRATE BINDING
PROTEIN BF1063

(Bacteroides
fragilis) 		PF07980
(SusD_RagB)
PF14322
(SusD-like_3) 		3 ARG A 524
PHE A 523
GLY A  97
 None
 0.70A 6fgdA-3i4gA:
undetectable		 6fgdA-3i4gA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k0s DNA MISMATCH REPAIR
PROTEIN MUTS

(Escherichia
coli) 		PF00488
(MutS_V)
PF01624
(MutS_I)
PF05188
(MutS_II)
PF05190
(MutS_IV)
PF05192
(MutS_III) 		3 ARG A  32
PHE A  36
GLY A  34
 None
 0.70A 6fgdA-3k0sA:
undetectable		 6fgdA-3k0sA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kya PUTATIVE PHOSPHATASE

(Bacteroides
thetaiotaomicron) 		PF01833
(TIG) 		3 ARG A 464
PHE A 423
GLY A 453
 None
 0.48A 6fgdA-3kyaA:
undetectable		 6fgdA-3kyaA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lah METHYL-ACCEPTING
CHEMOTAXIS PROTEIN

(Caldanaerobacter
subterraneus) 		PF07700
(HNOB) 		3 ARG A  68
PHE A 141
GLY A 143
 None
HEM  A 200 ( 4.9A)
None
 0.80A 6fgdA-3lahA:
undetectable		 6fgdA-3lahA:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lnt 2,3-BISPHOSPHOGLYCER
ATE-DEPENDENT
PHOSPHOGLYCERATE
MUTASE

(Burkholderia
pseudomallei) 		PF00300
(His_Phos_1) 		3 ARG A  19
PHE A  20
GLY A  95
 None
 0.69A 6fgdA-3lntA:
undetectable		 6fgdA-3lntA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mdq EXOPOLYPHOSPHATASE

(Cytophaga
hutchinsonii) 		PF02541
(Ppx-GppA) 		3 ARG A 119
PHE A 118
GLY A 120
 None
 0.80A 6fgdA-3mdqA:
undetectable		 6fgdA-3mdqA:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3njx RHAMNOGALACTURONASE
B

(Aspergillus
aculeatus) 		PF09284
(RhgB_N)
PF14683
(CBM-like)
PF14686
(fn3_3) 		3 ARG A 107
PHE A 108
GLY A  52
 SO4  A 904 (-3.7A)
None
None
 0.72A 6fgdA-3njxA:
undetectable		 6fgdA-3njxA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o8o 6-PHOSPHOFRUCTOKINAS
E SUBUNIT BETA

(Saccharomyces
cerevisiae) 		PF00365
(PFK) 		3 ARG B 752
PHE B 813
GLY B 809
 None
 0.81A 6fgdA-3o8oB:
2.6		 6fgdA-3o8oB:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p77 MHC RFP-Y CLASS I
ALPHA CHAIN

(Gallus gallus) 		PF00129
(MHC_I)
PF07654
(C1-set) 		3 ARG A 117
PHE A 114
GLY A 116
 None
 0.69A 6fgdA-3p77A:
undetectable		 6fgdA-3p77A:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pih UVRABC SYSTEM
PROTEIN A

(Thermotoga
maritima) 		PF00005
(ABC_tran) 		3 ARG A 715
PHE A 709
GLY A 721
 None
 0.63A 6fgdA-3pihA:
undetectable		 6fgdA-3pihA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pqs TRANSFERRIN-BINDING
PROTEIN

(Actinobacillus
pleuropneumoniae) 		PF01298
(TbpB_B_D)
PF17483
(TbpB_C)
PF17484
(TbpB_A) 		3 ARG A 164
PHE A 171
GLY A 177
 None
 0.69A 6fgdA-3pqsA:
undetectable		 6fgdA-3pqsA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r5y PUTATIVE
UNCHARACTERIZED
PROTEIN

(Nocardia
farcinica) 		PF04075
(F420H2_quin_red) 		3 ARG A  38
PHE A  35
GLY A  37
 None
F42  A 147 ( 4.7A)
None
 0.73A 6fgdA-3r5yA:
undetectable		 6fgdA-3r5yA:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uw2 PHOSPHOGLUCOMUTASE/P
HOSPHOMANNOMUTASE
FAMILY PROTEIN

(Burkholderia
thailandensis) 		PF00408
(PGM_PMM_IV)
PF02878
(PGM_PMM_I)
PF02879
(PGM_PMM_II)
PF02880
(PGM_PMM_III) 		3 ARG A 289
PHE A 418
GLY A 417
 None
 0.69A 6fgdA-3uw2A:
4.0		 6fgdA-3uw2A:
23.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ux8 EXCINUCLEASE ABC, A
SUBUNIT

(Geobacillus sp.
Y412MC52) 		PF00005
(ABC_tran) 		3 ARG A 735
PHE A 729
GLY A 741
 None
 0.80A 6fgdA-3ux8A:
undetectable		 6fgdA-3ux8A:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vuw TUMOR NECROSIS
FACTOR ALPHA-INDUCED
PROTEIN 3

(Homo sapiens) 		PF01754
(zf-A20) 		3 ARG E 763
PHE E 783
GLY E 777
 None
 0.81A 6fgdA-3vuwE:
undetectable		 6fgdA-3vuwE:
6.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vxi DYP

(Bjerkandera
adusta) 		PF04261
(Dyp_perox) 		3 ARG A 368
PHE A 369
GLY A 364
 None
 0.73A 6fgdA-3vxiA:
undetectable		 6fgdA-3vxiA:
24.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wyz RIBONUCLEASE P
PROTEIN COMPONENT 3

(Thermococcus
kodakarensis) 		PF01876
(RNase_P_p30) 		3 ARG A 117
PHE A 158
GLY A 121
 None
 0.82A 6fgdA-3wyzA:
undetectable		 6fgdA-3wyzA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c8y CAS6A

(Thermus
thermophilus) 		PF10040
(CRISPR_Cas6) 		3 ARG A 121
PHE A 122
GLY A 194
 None
 0.81A 6fgdA-4c8yA:
undetectable		 6fgdA-4c8yA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ci8 ECHINODERM
MICROTUBULE-ASSOCIAT
ED PROTEIN-LIKE 1

(Homo sapiens) 		PF00400
(WD40)
PF03451
(HELP) 		3 ARG A 523
PHE A 503
GLY A 504
 SO4  A1821 (-4.0A)
None
SO4  A1821 ( 4.6A)
 0.79A 6fgdA-4ci8A:
undetectable		 6fgdA-4ci8A:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4csb VIRULENCE ASSOCIATED
PROTEIN VAPD

(Rhodococcus
hoagii) 		PF05526
(R_equi_Vir) 		3 ARG A 111
PHE A 104
GLY A 113
 None
 0.74A 6fgdA-4csbA:
undetectable		 6fgdA-4csbA:
15.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eff AROMATIC-AMINO-ACID
AMINOTRANSFERASE

(Burkholderia
pseudomallei) 		PF00155
(Aminotran_1_2) 		3 ARG A 317
PHE A 219
GLY A 218
 None
 0.81A 6fgdA-4effA:
2.7		 6fgdA-4effA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jb9 ANTIBODY VRC06 HEAVY
CHAIN

(Homo sapiens) 		PF07654
(C1-set) 		3 ARG H  95
PHE H 100
GLY H 100
 None
 0.69A 6fgdA-4jb9H:
undetectable		 6fgdA-4jb9H:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k1x NADPH:FERREDOXIN
REDUCTASE

(Rhodobacter
capsulatus) 		PF00175
(NAD_binding_1)
PF00970
(FAD_binding_6) 		3 ARG A 259
PHE A 261
GLY A 253
 None
 0.72A 6fgdA-4k1xA:
undetectable		 6fgdA-4k1xA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4odi PHOSPHOGLYCERATE
MUTASE PGMII

(Toxoplasma
gondii) 		PF00300
(His_Phos_1) 		3 ARG A  36
PHE A  37
GLY A 112
 None
 0.79A 6fgdA-4odiA:
undetectable		 6fgdA-4odiA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4odj S-ADENOSYLMETHIONINE
SYNTHASE

(Cryptosporidium
hominis) 		PF00438
(S-AdoMet_synt_N)
PF02772
(S-AdoMet_synt_M)
PF02773
(S-AdoMet_synt_C) 		3 ARG A 392
PHE A 390
GLY A 388
 None
 0.73A 6fgdA-4odjA:
undetectable		 6fgdA-4odjA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p6y AMINOPEPTIDASE

(Thermotoga
maritima) 		PF05343
(Peptidase_M42) 		3 ARG A  96
PHE A  97
GLY A 100
 None
 0.80A 6fgdA-4p6yA:
3.8		 6fgdA-4p6yA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qi4 CELLOBIOSE
DEHYDROGENASE

(Crassicarpon
hotsonii) 		PF00732
(GMC_oxred_N)
PF00734
(CBM_1)
PF05199
(GMC_oxred_C) 		3 ARG A 445
PHE A 788
GLY A 447
 None
 0.75A 6fgdA-4qi4A:
2.7		 6fgdA-4qi4A:
21.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4u90 GEPHYRIN

(Rattus
norvegicus) 		PF00994
(MoCF_biosynth)
PF03453
(MoeA_N)
PF03454
(MoeA_C) 		3 ARG A 387
PHE A 388
GLY A 406
 BU1  A 801 ( 4.3A)
None
None
 0.17A 6fgdA-4u90A:
50.7		 6fgdA-4u90A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uri CHITINASE-RELATED
AGGLUTININ

(Robinia
pseudoacacia) 		PF00704
(Glyco_hydro_18) 		3 ARG A 284
PHE A 285
GLY A 271
 None
 0.76A 6fgdA-4uriA:
undetectable		 6fgdA-4uriA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wip SEGMENT POLARITY
PROTEIN DISHEVELLED
HOMOLOG DVL-2

(Homo sapiens) 		PF00778
(DIX) 		3 ARG A  84
PHE A  81
GLY A  83
 None
 0.76A 6fgdA-4wipA:
undetectable		 6fgdA-4wipA:
12.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y63 HISTO-BLOOD GROUP
ABO SYSTEM
TRANSFERASE

(Homo sapiens) 		PF03414
(Glyco_transf_6) 		3 ARG A 241
PHE A 244
GLY A 261
 None
 0.82A 6fgdA-4y63A:
undetectable		 6fgdA-4y63A:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ys8 2-C-METHYL-D-ERYTHRI
TOL 4-PHOSPHATE
CYTIDYLYLTRANSFERASE

(Burkholderia
thailandensis) 		PF01128
(IspD) 		3 ARG A 212
PHE A 214
GLY A 113
 None
 0.81A 6fgdA-4ys8A:
undetectable		 6fgdA-4ys8A:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yyc PUTATIVE
TRIMETHYLAMINE
METHYLTRANSFERASE

(Sinorhizobium
meliloti) 		PF06253
(MTTB) 		3 ARG A 354
PHE A 353
GLY A 315
 UNL  A 601 ( 3.0A)
None
None
 0.77A 6fgdA-4yycA:
undetectable		 6fgdA-4yycA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aw4 NA+,K+-ATPASE BETA
SUBUNIT

(Squalus
acanthias) 		PF00287
(Na_K-ATPase) 		3 ARG B  28
PHE B  25
GLY B  27
 CLR  B3001 (-3.5A)
None
None
 0.74A 6fgdA-5aw4B:
undetectable		 6fgdA-5aw4B:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5csu 4-ALPHA-GLUCANOTRANS
FERASE DPE1,
CHLOROPLASTIC/AMYLOP
LASTIC

(Arabidopsis
thaliana) 		PF02446
(Glyco_hydro_77) 		3 ARG A 376
PHE A 375
GLY A 377
 None
 0.67A 6fgdA-5csuA:
undetectable		 6fgdA-5csuA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dx5 METHIONINE
GAMMA-LYASE

(Clostridium
sporogenes) 		PF01053
(Cys_Met_Meta_PP) 		3 ARG A  48
PHE A  49
GLY A  45
 None
 0.79A 6fgdA-5dx5A:
undetectable		 6fgdA-5dx5A:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e7t MINOR STRUCTURAL
PROTEIN 4
MAJOR STRUCTURAL
PROTEIN 1

(Lactococcus
phage Tuc2009;
Lactococcus
phage Tuc2009) 		no annotation
no annotation 		3 ARG G   9
PHE A 232
GLY A 234
 None
 0.77A 6fgdA-5e7tG:
undetectable		 6fgdA-5e7tG:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5exv HEMIN-DEGRADING
HEMS.CHUX DOMAIN
PROTEIN

(Vibrio cholerae) 		PF06228
(ChuX_HutX) 		3 ARG A 122
PHE A 119
GLY A 121
 None
 0.77A 6fgdA-5exvA:
undetectable		 6fgdA-5exvA:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gpr CHITINASE

(Ostrinia
furnacalis) 		PF00704
(Glyco_hydro_18)
PF08329
(ChitinaseA_N) 		3 ARG A 165
PHE A 167
GLY A 161
 ARG  A 165 ( 0.6A)
PHE  A 167 ( 1.3A)
GLY  A 161 ( 0.0A)
 0.73A 6fgdA-5gprA:
undetectable		 6fgdA-5gprA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h60 TRANSFERASE

(Escherichia
coli) 		no annotation 3 ARG A  54
PHE A 187
GLY A 183
 None
 0.77A 6fgdA-5h60A:
undetectable		 6fgdA-5h60A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h9u S-ADENOSYLMETHIONINE
SYNTHASE

(Thermus
thermophilus) 		no annotation 3 ARG C 375
PHE C 373
GLY C 371
 None
 0.80A 6fgdA-5h9uC:
undetectable		 6fgdA-5h9uC:
25.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iz5 CYTOSOLIC
PHOSPHOLIPASE A2
DELTA

(Homo sapiens) 		no annotation 3 ARG B 510
PHE B 507
GLY B 509
 None
 0.77A 6fgdA-5iz5B:
undetectable		 6fgdA-5iz5B:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jjo UNCHARACTERIZED
PROTEIN

(Pseudomonas
aeruginosa) 		PF08238
(Sel1) 		3 ARG A 264
PHE A 265
GLY A 216
 None
 0.65A 6fgdA-5jjoA:
undetectable		 6fgdA-5jjoA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jkp UNCHARACTERIZED
PROTEIN

(Pseudomonas
aeruginosa) 		PF08238
(Sel1) 		3 ARG A 264
PHE A 265
GLY A 216
 None
 0.66A 6fgdA-5jkpA:
undetectable		 6fgdA-5jkpA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m0k BETA-XYLANASE

(Cellulomonas
flavigena) 		no annotation 3 ARG A 268
PHE A 282
GLY A 286
 None
 0.75A 6fgdA-5m0kA:
undetectable		 6fgdA-5m0kA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o71 UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 25

(Homo sapiens) 		no annotation 3 ARG A 445
PHE A 446
GLY A 440
 None
 0.47A 6fgdA-5o71A:
undetectable		 6fgdA-5o71A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oie -

(-) 		no annotation 3 ARG A 170
PHE A 290
GLY A 293
 None
 0.69A 6fgdA-5oieA:
undetectable		 6fgdA-5oieA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t1q N-ACETYLMURAMOYL-L-A
LANINE AMIDASE
DOMAIN-CONTAINING
PROTEIN
SAOUHSC_02979

(Staphylococcus
aureus) 		PF01832
(Glucosaminidase)
PF05257
(CHAP) 		3 ARG A 400
PHE A 399
GLY A 373
 None
 0.62A 6fgdA-5t1qA:
undetectable		 6fgdA-5t1qA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t8t S-ADENOSYLMETHIONINE
SYNTHASE

(Neisseria
gonorrhoeae) 		PF00438
(S-AdoMet_synt_N)
PF02772
(S-AdoMet_synt_M)
PF02773
(S-AdoMet_synt_C) 		3 ARG A 367
PHE A 365
GLY A 363
 None
 0.76A 6fgdA-5t8tA:
undetectable		 6fgdA-5t8tA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tvj ENHANCED
INTRACELLULAR
SURVIVAL PROTEIN

(Mycobacterium
tuberculosis) 		PF13527
(Acetyltransf_9)
PF13530
(SCP2_2) 		3 ARG A 297
PHE A 129
GLY A 130
 None
 0.79A 6fgdA-5tvjA:
undetectable		 6fgdA-5tvjA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u8z CAROTENOID OXYGENASE
1

(Neurospora
crassa) 		PF03055
(RPE65) 		3 ARG A 157
PHE A 227
GLY A 231
 None
 0.69A 6fgdA-5u8zA:
undetectable		 6fgdA-5u8zA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uti QUEUINE
TRNA-RIBOSYLTRANSFER
ASE

(Zymomonas
mobilis) 		no annotation 3 ARG A 211
PHE A 207
GLY A 204
 None
 0.80A 6fgdA-5utiA:
undetectable		 6fgdA-5utiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w1e PUTATIVE
TRANSCRIPTIONAL
REGULATOR

(Streptomyces
coelicolor) 		no annotation 3 ARG A 121
PHE A 122
GLY A 139
 GOL  A 603 (-3.3A)
PHB  A 602 (-4.0A)
None
 0.65A 6fgdA-5w1eA:
undetectable		 6fgdA-5w1eA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wy5 NON-STRUCTURAL
MAINTENANCE OF
CHROMOSOMES ELEMENT
1 HOMOLOG
MELANOMA-ASSOCIATED
ANTIGEN G1

(Homo sapiens;
Homo sapiens) 		PF07574
(SMC_Nse1)
PF08746
(zf-RING-like)
PF01454
(MAGE) 		3 ARG A  16
PHE B 138
GLY B 139
 None
 0.81A 6fgdA-5wy5A:
undetectable		 6fgdA-5wy5A:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x1e ICMW

(Legionella
pneumophila) 		no annotation 3 ARG B 121
PHE B 118
GLY B  75
 None
 0.73A 6fgdA-5x1eB:
undetectable		 6fgdA-5x1eB:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x9w DNA MISMATCH REPAIR
PROTEIN MUTS

(Neisseria
gonorrhoeae) 		no annotation 3 ARG A  28
PHE A  32
GLY A  30
 None
 0.67A 6fgdA-5x9wA:
undetectable		 6fgdA-5x9wA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yb7 L-AMINO ACID
OXIDASE/MONOOXYGENAS
E

(Pseudomonas sp.
AIU 813) 		no annotation 3 ARG A 359
PHE A 473
GLY A 475
 None
ORN  A 602 (-4.6A)
None
 0.69A 6fgdA-5yb7A:
3.9		 6fgdA-5yb7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yem CATALASE

(Mycothermus
thermophilus) 		no annotation 3 ARG A 689
PHE A 690
GLY A 642
 None
 0.70A 6fgdA-5yemA:
4.8		 6fgdA-5yemA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zxd -

(-) 		no annotation 3 ARG A 452
PHE A 431
GLY A 432
 None
 0.74A 6fgdA-5zxdA:
undetectable		 6fgdA-5zxdA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6guo -

(-) 		no annotation 3 ARG A 220
PHE A 161
GLY A 294
 None
 0.76A 6fgdA-6guoA:
2.6		 6fgdA-6guoA:
undetectable