SIMILAR PATTERNS OF AMINO ACIDS FOR 6FGD_A_ACTA819

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1aa0 FIBRITIN

(Escherichia
virus T4) 		PF07921
(Fibritin_C) 		3 ARG A 471
GLY A 474
GLU A 475
 None
None
ZN  A 565 (-1.3A)
 0.62A 6fgdA-1aa0A:
undetectable		 6fgdA-1aa0A:
14.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dkr PHOSPHORIBOSYL
PYROPHOSPHATE
SYNTHETASE

(Bacillus
subtilis) 		PF13793
(Pribosyltran_N)
PF14572
(Pribosyl_synth) 		3 ARG A  39
GLY A  43
GLU A  44
 None
 0.33A 6fgdA-1dkrA:
1.7		 6fgdA-1dkrA:
24.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ft5 CYTOCHROME C554

(Nitrosomonas
europaea) 		PF13435
(Cytochrome_C554) 		3 ARG A 133
GLY A  93
GLU A  89
 None
 0.62A 6fgdA-1ft5A:
undetectable		 6fgdA-1ft5A:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hfh FACTOR H, 15TH AND
16TH C-MODULE PAIR

(Homo sapiens) 		PF00084
(Sushi) 		3 ARG A  41
GLY A  63
GLU A  62
 None
 0.61A 6fgdA-1hfhA:
undetectable		 6fgdA-1hfhA:
13.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uek 4-(CYTIDINE
5'-DIPHOSPHO)-2C-MET
HYL-D-ERYTHRITOL
KINASE

(Thermus
thermophilus) 		PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C) 		3 ARG A 162
GLY A  88
GLU A  87
 None
 0.58A 6fgdA-1uekA:
0.7		 6fgdA-1uekA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uf3 HYPOTHETICAL PROTEIN
TT1561

(Thermus
thermophilus) 		PF14582
(Metallophos_3) 		3 ARG A 228
GLY A 210
GLU A 211
 None
 0.50A 6fgdA-1uf3A:
1.5		 6fgdA-1uf3A:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v26 LONG-CHAIN-FATTY-ACI
D-COA SYNTHETASE

(Thermus
thermophilus) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		3 ARG A  39
GLY A  43
GLU A  44
 None
 0.63A 6fgdA-1v26A:
undetectable		 6fgdA-1v26A:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w25 STALKED-CELL
DIFFERENTIATION
CONTROLLING PROTEIN

(Caulobacter
vibrioides) 		PF00072
(Response_reg)
PF00990
(GGDEF) 		3 ARG A 366
GLY A 369
GLU A 370
 C2E  A 501 ( 4.1A)
C2E  A 501 (-3.3A)
C2E  A 501 (-4.7A)
 0.38A 6fgdA-1w25A:
4.1		 6fgdA-1w25A:
23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wg4 HYPOTHETICAL PROTEIN
(RIKEN CDNA
6030486K23)

(Mus musculus) 		PF00076
(RRM_1) 		3 ARG A  76
GLY A  80
GLU A  81
 None
 0.50A 6fgdA-1wg4A:
undetectable		 6fgdA-1wg4A:
13.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wot PUTATIVE MINIMAL
NUCLEOTIDYLTRANSFERA
SE

(Thermus
thermophilus) 		PF01909
(NTP_transf_2) 		3 ARG A  52
GLY A  51
GLU A  50
 None
 0.63A 6fgdA-1wotA:
undetectable		 6fgdA-1wotA:
14.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wp9 ATP-DEPENDENT RNA
HELICASE, PUTATIVE

(Pyrococcus
furiosus) 		PF00270
(DEAD)
PF00271
(Helicase_C) 		3 ARG A  95
GLY A  88
GLU A  89
 None
 0.58A 6fgdA-1wp9A:
0.7		 6fgdA-1wp9A:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z47 PUTATIVE
ABC-TRANSPORTER
ATP-BINDING PROTEIN

(Alicyclobacillus
acidocaldarius) 		PF00005
(ABC_tran)
PF08402
(TOBE_2) 		3 ARG A 318
GLY A 322
GLU A 323
 None
 0.58A 6fgdA-1z47A:
1.3		 6fgdA-1z47A:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bfw GLGA GLYCOGEN
SYNTHASE

(Pyrococcus
abyssi) 		PF00534
(Glycos_transf_1) 		3 ARG A 285
GLY A 249
GLU A 248
 None
 0.57A 6fgdA-2bfwA:
2.0		 6fgdA-2bfwA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c5u RNA LIGASE

(Escherichia
virus T4) 		PF09511
(RNA_lig_T4_1) 		3 ARG A 182
GLY A 187
GLU A 188
 None
 0.38A 6fgdA-2c5uA:
undetectable		 6fgdA-2c5uA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ef4 ARGINASE

(Thermus
thermophilus) 		PF00491
(Arginase) 		3 ARG A 177
GLY A 174
GLU A 175
 None
 0.61A 6fgdA-2ef4A:
5.2		 6fgdA-2ef4A:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2esf CARBONIC ANHYDRASE 2

(Escherichia
coli) 		PF00484
(Pro_CA) 		3 ARG A 142
GLY A 135
GLU A 136
 None
 0.39A 6fgdA-2esfA:
undetectable		 6fgdA-2esfA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gbx BIPHENYL
2,3-DIOXYGENASE
ALPHA SUBUNIT

(Sphingobium
yanoikuyae) 		PF00355
(Rieske)
PF00848
(Ring_hydroxyl_A) 		3 ARG A 165
GLY A 162
GLU A 163
 None
 0.61A 6fgdA-2gbxA:
undetectable		 6fgdA-2gbxA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gep SULFITE REDUCTASE
HEMOPROTEIN

(Escherichia
coli) 		PF01077
(NIR_SIR)
PF03460
(NIR_SIR_ferr) 		3 ARG A 509
GLY A 547
GLU A 546
 None
 0.60A 6fgdA-2gepA:
1.5		 6fgdA-2gepA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ipz GENERAL CONTROL
PROTEIN GCN4

(Saccharomyces
cerevisiae) 		no annotation 3 ARG A  34
GLY A  32
GLU A  33
 None
 0.58A 6fgdA-2ipzA:
undetectable		 6fgdA-2ipzA:
6.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jyp ARAGONITE PROTEIN
AP7

(Haliotis
rufescens) 		no annotation 3 ARG A  26
GLY A  22
GLU A  23
 None
 0.45A 6fgdA-2jypA:
undetectable		 6fgdA-2jypA:
6.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lkn AH
RECEPTOR-INTERACTING
PROTEIN

(Homo sapiens) 		PF00254
(FKBP_C) 		3 ARG A  81
GLY A  23
GLU A  24
 None
 0.54A 6fgdA-2lknA:
undetectable		 6fgdA-2lknA:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nuj THIOESTERASE
SUPERFAMILY

(Jannaschia) 		PF13279
(4HBT_2) 		3 ARG A  31
GLY A  91
GLU A  92
 None
 0.47A 6fgdA-2nujA:
undetectable		 6fgdA-2nujA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o4x STAPHYLOCOCCAL
NUCLEASE
DOMAIN-CONTAINING
PROTEIN 1

(Homo sapiens) 		PF00567
(TUDOR) 		3 ARG B 724
GLY B 708
GLU B 709
 None
 0.60A 6fgdA-2o4xB:
undetectable		 6fgdA-2o4xB:
14.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ra1 SURFACE LAYER
PROTEIN

(Geobacillus
stearothermophilus) 		PF13205
(Big_5) 		3 ARG A 120
GLY A 117
GLU A 118
 None
 0.46A 6fgdA-2ra1A:
undetectable		 6fgdA-2ra1A:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rfm PUTATIVE ANKYRIN
REPEAT PROTEIN
TV1425

(Thermoplasma
volcanium) 		PF12796
(Ank_2)
PF13857
(Ank_5) 		3 ARG A 127
GLY A 131
GLU A 132
 SO4  A 193 (-2.6A)
None
GOL  A 198 ( 4.7A)
 0.54A 6fgdA-2rfmA:
undetectable		 6fgdA-2rfmA:
17.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uv8 FATTY ACID SYNTHASE
SUBUNIT BETA (FAS1)

(Saccharomyces
cerevisiae) 		PF00698
(Acyl_transf_1)
PF01575
(MaoC_dehydratas)
PF08354
(DUF1729)
PF13452
(MaoC_dehydrat_N)
PF16073
(SAT) 		3 ARG G 419
GLY G 333
GLU G 332
 None
 0.58A 6fgdA-2uv8G:
undetectable		 6fgdA-2uv8G:
12.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wu0 PHYTASE

(Klebsiella
pneumoniae) 		PF00328
(His_Phos_2) 		3 ARG A 327
GLY A 332
GLU A 333
 None
 0.49A 6fgdA-2wu0A:
undetectable		 6fgdA-2wu0A:
23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a2q 6-AMINOHEXANOATE-CYC
LIC-DIMER HYDROLASE

(Arthrobacter
sp. KI72) 		PF01425
(Amidase) 		3 ARG A 350
GLY A 409
GLU A 408
 None
 0.63A 6fgdA-3a2qA:
undetectable		 6fgdA-3a2qA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ahi XYLULOSE
5-PHOSPHATE/FRUCTOSE
6-PHOSPHATE
PHOSPHOKETOLASE

(Bifidobacterium
breve) 		PF03894
(XFP)
PF09363
(XFP_C)
PF09364
(XFP_N) 		3 ARG A 370
GLY A 367
GLU A 368
 None
 0.47A 6fgdA-3ahiA:
undetectable		 6fgdA-3ahiA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ai7 XYLULOSE-5-PHOSPHATE
/FRUCTOSE-6-PHOSPHAT
E PHOSPHOKETOLASE

(Bifidobacterium
longum) 		PF03894
(XFP)
PF09363
(XFP_C)
PF09364
(XFP_N) 		3 ARG A 370
GLY A 367
GLU A 368
 None
 0.50A 6fgdA-3ai7A:
undetectable		 6fgdA-3ai7A:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c3v ARACHIN ARAH3
ISOFORM

(Arachis
hypogaea) 		PF00190
(Cupin_1) 		3 ARG A  76
GLY A  50
GLU A  49
 None
 0.55A 6fgdA-3c3vA:
undetectable		 6fgdA-3c3vA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eoq PUTATIVE ZINC
PROTEASE

(Thermus
thermophilus) 		PF00675
(Peptidase_M16)
PF05193
(Peptidase_M16_C) 		3 ARG A 352
GLY A 346
GLU A 347
 None
 0.40A 6fgdA-3eoqA:
undetectable		 6fgdA-3eoqA:
24.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j0h PHIKZ029

(Pseudomonas
virus phiKZ) 		no annotation 3 ARG A 315
GLY A 337
GLU A 338
 None
 0.57A 6fgdA-3j0hA:
undetectable		 6fgdA-3j0hA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jby V(D)J
RECOMBINATION-ACTIVA
TING PROTEIN 1

(Danio rerio) 		PF12940
(RAG1) 		3 ARG A 652
GLY A 655
GLU A 656
 None
 0.60A 6fgdA-3jbyA:
undetectable		 6fgdA-3jbyA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kh5 PROTEIN MJ1225

(Methanocaldococcus
jannaschii) 		PF00571
(CBS) 		3 ARG A 224
GLY A 164
GLU A 165
 None
SO4  A 285 (-2.7A)
None
 0.61A 6fgdA-3kh5A:
undetectable		 6fgdA-3kh5A:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3krt CROTONYL COA
REDUCTASE

(Streptomyces
coelicolor) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		3 ARG A 307
GLY A 312
GLU A 313
 None
 0.61A 6fgdA-3krtA:
undetectable		 6fgdA-3krtA:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l01 GLGA GLYCOGEN
SYNTHASE

(Pyrococcus
abyssi) 		PF00534
(Glycos_transf_1)
PF08323
(Glyco_transf_5) 		3 ARG A 285
GLY A 249
GLU A 248
 None
 0.53A 6fgdA-3l01A:
2.5		 6fgdA-3l01A:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l4d STEROL 14-ALPHA
DEMETHYLASE

(Leishmania
infantum) 		PF00067
(p450) 		3 ARG A 232
GLY A 110
GLU A 111
 None
 0.51A 6fgdA-3l4dA:
undetectable		 6fgdA-3l4dA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mmp ELONGATION FACTOR TU
2, ELONGATION FACTOR
TS

(Escherichia
coli) 		PF00009
(GTP_EFTU)
PF00889
(EF_TS)
PF03143
(GTP_EFTU_D3)
PF03144
(GTP_EFTU_D2) 		3 ARG A1230
GLY A1271
GLU A1272
 None
 0.50A 6fgdA-3mmpA:
undetectable		 6fgdA-3mmpA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nok GLUTAMINYL CYCLASE

(Myxococcus
xanthus) 		PF05096
(Glu_cyclase_2) 		3 ARG A 121
GLY A 104
GLU A 103
 None
 0.55A 6fgdA-3nokA:
undetectable		 6fgdA-3nokA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3npf PUTATIVE
DIPEPTIDYL-PEPTIDASE
VI

(Bacteroides
ovatus) 		PF00877
(NLPC_P60) 		3 ARG A 251
GLY A 260
GLU A 259
 None
 0.63A 6fgdA-3npfA:
undetectable		 6fgdA-3npfA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nvn PLEXIN-C1

(Homo sapiens) 		PF01437
(PSI) 		3 ARG B 387
GLY B 405
GLU B 406
 None
 0.54A 6fgdA-3nvnB:
undetectable		 6fgdA-3nvnB:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p1v METALLO-ENDOPEPTIDAS
E

(Bacteroides
ovatus) 		PF09471
(Peptidase_M64)
PF16217
(M64_N) 		3 ARG A 393
GLY A 383
GLU A 382
 None
 0.62A 6fgdA-3p1vA:
undetectable		 6fgdA-3p1vA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p42 PREDICTED PROTEIN

(Escherichia
coli) 		PF06251
(Caps_synth_GfcC) 		3 ARG A 115
GLY A 195
GLU A 196
 None
 0.58A 6fgdA-3p42A:
undetectable		 6fgdA-3p42A:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qsj NUDIX HYDROLASE

(Alicyclobacillus
acidocaldarius) 		PF00293
(NUDIX) 		3 ARG A  91
GLY A  93
GLU A  94
 None
 0.63A 6fgdA-3qsjA:
undetectable		 6fgdA-3qsjA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qv0 MITOCHONDRIAL ACIDIC
PROTEIN MAM33

(Saccharomyces
cerevisiae) 		PF02330
(MAM33) 		3 ARG A 102
GLY A 106
GLU A 107
 None
 0.39A 6fgdA-3qv0A:
undetectable		 6fgdA-3qv0A:
16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ru8 ANTIBODY B12, LIGHT
CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		3 ARG L  78
GLY L  16
GLU L  17
 None
 0.25A 6fgdA-3ru8L:
undetectable		 6fgdA-3ru8L:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3skd PUTATIVE
UNCHARACTERIZED
PROTEIN TTHB187

(Thermus
thermophilus) 		no annotation 3 ARG A 251
GLY A 254
GLU A 255
 None
 0.62A 6fgdA-3skdA:
undetectable		 6fgdA-3skdA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tvk DIGUANYLATE CYCLASE
DGCZ

(Escherichia
coli) 		PF00990
(GGDEF) 		3 ARG A 204
GLY A 207
GLU A 208
 C2E  A 501 (-3.7A)
C2E  A 501 (-3.4A)
C2E  A 501 (-4.0A)
 0.48A 6fgdA-3tvkA:
undetectable		 6fgdA-3tvkA:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ujh GLUCOSE-6-PHOSPHATE
ISOMERASE

(Toxoplasma
gondii) 		PF00342
(PGI) 		3 ARG A 140
GLY A 137
GLU A 138
 None
 0.56A 6fgdA-3ujhA:
2.3		 6fgdA-3ujhA:
24.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vte TETRAHYDROCANNABINOL
IC ACID SYNTHASE

(Cannabis sativa) 		PF01565
(FAD_binding_4)
PF08031
(BBE) 		3 ARG A 195
GLY A 421
GLU A 424
 None
 0.58A 6fgdA-3vteA:
undetectable		 6fgdA-3vteA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wad GLYCOSYLTRANSFERASE

(Streptomyces
halstedii) 		PF06722
(DUF1205) 		3 ARG A 176
GLY A 169
GLU A 170
 None
 0.55A 6fgdA-3wadA:
undetectable		 6fgdA-3wadA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wqy ALANINE--TRNA LIGASE

(Archaeoglobus
fulgidus) 		PF01411
(tRNA-synt_2c)
PF02272
(DHHA1)
PF07973
(tRNA_SAD) 		3 ARG A 305
GLY A 302
GLU A 303
 None
 0.63A 6fgdA-3wqyA:
undetectable		 6fgdA-3wqyA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zu4 PUTATIVE REDUCTASE
YPO4104/Y4119/YP_401
1

(Yersinia pestis) 		PF07055
(Eno-Rase_FAD_bd)
PF12241
(Enoyl_reductase)
PF12242
(Eno-Rase_NADH_b) 		3 ARG A 267
GLY A 328
GLU A 327
 None
 0.56A 6fgdA-3zu4A:
undetectable		 6fgdA-3zu4A:
23.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4avr PA4485

(Pseudomonas
aeruginosa) 		PF03330
(DPBB_1) 		3 ARG A  17
GLY A  21
GLU A  22
 None
 0.62A 6fgdA-4avrA:
undetectable		 6fgdA-4avrA:
12.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b3k BETA-GLUCOSIDASE

(Streptococcus
pyogenes) 		PF00232
(Glyco_hydro_1) 		3 ARG A 376
GLY A 373
GLU A 374
 None
 0.41A 6fgdA-4b3kA:
undetectable		 6fgdA-4b3kA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cza NA+/H+ ANTIPORTER,
PUTATIVE

(Pyrococcus
abyssi) 		PF00999
(Na_H_Exchanger) 		3 ARG A 337
GLY A 360
GLU A 359
 None
 0.56A 6fgdA-4czaA:
undetectable		 6fgdA-4czaA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d4l 6-PHOSPHOFRUCTO-2-KI
NASE/FRUCTOSE-2,6-BI
SPHOSPHATASE 3

(Homo sapiens) 		PF00300
(His_Phos_1)
PF01591
(6PF2K) 		3 ARG A  74
GLY A  71
GLU A  72
 None
 0.49A 6fgdA-4d4lA:
undetectable		 6fgdA-4d4lA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d7s STHK_CNBD_CGMP

(Spirochaeta
thermophila) 		PF00027
(cNMP_binding) 		3 ARG A 382
GLY A 325
GLU A 326
 None
 0.43A 6fgdA-4d7sA:
undetectable		 6fgdA-4d7sA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dn7 ABC TRANSPORTER,
ATP-BINDING PROTEIN

(Methanosarcina
mazei) 		PF01458
(UPF0051) 		3 ARG A  67
GLY A  66
GLU A  65
 None
 0.61A 6fgdA-4dn7A:
undetectable		 6fgdA-4dn7A:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ewc PUTATIVE
NUCLEOPROTEIN

(Salmon isavirus) 		no annotation 3 ARG A 491
GLY A 567
GLU A 568
 None
 0.62A 6fgdA-4ewcA:
undetectable		 6fgdA-4ewcA:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fwm PROPIONATE KINASE

(Salmonella
enterica) 		PF00871
(Acetate_kinase) 		3 ARG A 363
GLY A 361
GLU A 362
 None
 0.47A 6fgdA-4fwmA:
undetectable		 6fgdA-4fwmA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g3j STEROL
14-ALPHA-DEMETHYLASE

(Trypanosoma
brucei) 		PF00067
(p450) 		3 ARG A 233
GLY A 111
GLU A 112
 None
 0.46A 6fgdA-4g3jA:
undetectable		 6fgdA-4g3jA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4geu SPINDLE ASSEMBLY
ABNORMAL PROTEIN 6

(Caenorhabditis
elegans) 		PF16531
(SAS-6_N) 		3 ARG A  42
GLY A  47
GLU A  48
 None
 0.59A 6fgdA-4geuA:
undetectable		 6fgdA-4geuA:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h54 DIGUANYLATE CYCLASE
YDEH

(Escherichia
coli) 		PF00990
(GGDEF) 		3 ARG A 204
GLY A 207
GLU A 208
 GAV  A 402 (-3.2A)
GAV  A 402 (-3.3A)
MG  A 403 ( 2.2A)
 0.41A 6fgdA-4h54A:
undetectable		 6fgdA-4h54A:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hae CHROMODOMAIN Y-LIKE
PROTEIN 2

(Homo sapiens) 		PF00385
(Chromo) 		3 ARG A  28
GLY A  33
GLU A  36
 SO4  A 101 (-3.0A)
UNX  A 107 ( 3.5A)
None
 0.61A 6fgdA-4haeA:
undetectable		 6fgdA-4haeA:
10.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hh8 BUTYROPHILIN
SUBFAMILY 1 MEMBER
A1

(Bos taurus) 		PF07686
(V-set)
PF08205
(C2-set_2) 		3 ARG A  66
GLY A  59
GLU A  60
 None
 0.58A 6fgdA-4hh8A:
undetectable		 6fgdA-4hh8A:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hjc ENVELOPE
GLYCOPROTEIN

(Rift Valley
fever
phlebovirus) 		PF07245
(Phlebovirus_G2) 		3 ARG A 933
GLY A 930
GLU A 931
 None
 0.47A 6fgdA-4hjcA:
undetectable		 6fgdA-4hjcA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j01 TRANSCRIPTION FACTOR
HETR

(Fischerella
thermalis) 		PF03574
(Peptidase_S48) 		3 ARG A 189
GLY A  32
GLU A  99
 None
 0.62A 6fgdA-4j01A:
undetectable		 6fgdA-4j01A:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4muo UNCHARACTERIZED
PROTEIN YBIB

(Escherichia
coli) 		PF02885
(Glycos_trans_3N) 		3 ARG A 221
GLY A 194
GLU A 195
 None
 0.62A 6fgdA-4muoA:
2.9		 6fgdA-4muoA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ncc FAB FRAGMENT LIGHT

(Mus musculus) 		no annotation 3 ARG L  76
GLY L  16
GLU L  17
 None
 0.55A 6fgdA-4nccL:
undetectable		 6fgdA-4nccL:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4odb OUTER CAPSID PROTEIN
SIGMA-1
JUNCTIONAL ADHESION
MOLECULE A

(Mammalian
orthoreovirus;
Homo sapiens) 		PF01664
(Reo_sigma1)
PF07686
(V-set) 		3 ARG A 333
GLY D 116
GLU D 113
 None
 0.58A 6fgdA-4odbA:
undetectable		 6fgdA-4odbA:
17.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oki PHTHIOCEROL
SYNTHESIS POLYKETIDE
SYNTHASE TYPE I PPSC

(Mycobacterium
tuberculosis) 		PF00107
(ADH_zinc_N) 		3 ARG A 721
GLY A 695
GLU A 696
 None
 0.59A 6fgdA-4okiA:
undetectable		 6fgdA-4okiA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oro POLYMERASE PB2

(Influenza B
virus) 		PF00604
(Flu_PB2) 		3 ARG A 368
GLY A 370
GLU A 371
 None
 0.52A 6fgdA-4oroA:
undetectable		 6fgdA-4oroA:
16.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ozu CORONIN

(Toxoplasma
gondii) 		PF00400
(WD40)
PF08953
(DUF1899)
PF16300
(WD40_4) 		3 ARG A 200
GLY A 380
GLU A 381
 None
 0.60A 6fgdA-4ozuA:
undetectable		 6fgdA-4ozuA:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pys BETA-N-ACETYLHEXOSAM
INIDASE

(Bacteroides
fragilis) 		PF00728
(Glyco_hydro_20)
PF02838
(Glyco_hydro_20b) 		3 ARG A 187
GLY A 185
GLU A 182
 None
 0.63A 6fgdA-4pysA:
3.0		 6fgdA-4pysA:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q4y COXSACKIEVIRUS
CAPSID PROTEIN VP3

(Enterovirus C) 		PF00073
(Rhv) 		3 ARG 3 176
GLY 3 186
GLU 3 185
 None
 0.62A 6fgdA-4q4y3:
undetectable		 6fgdA-4q4y3:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qko PYOCIN-S2

(Pseudomonas
aeruginosa) 		no annotation 3 ARG B 680
GLY B 583
GLU B 584
 None
 0.54A 6fgdA-4qkoB:
undetectable		 6fgdA-4qkoB:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r0k DIPEPTIDYL-PEPTIDASE
VI

(Bacteroides
thetaiotaomicron) 		PF00877
(NLPC_P60) 		3 ARG A 251
GLY A 260
GLU A 259
 None
 0.60A 6fgdA-4r0kA:
undetectable		 6fgdA-4r0kA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u48 PUTATIVE INNER
MEMBRANE LIPOPROTEIN

(Salmonella
enterica) 		PF00207
(A2M)
PF01835
(A2M_N)
PF07703
(A2M_N_2)
PF10569
(Thiol-ester_cl)
PF11974
(MG1) 		3 ARG A1608
GLY A1518
GLU A1519
 None
 0.63A 6fgdA-4u48A:
undetectable		 6fgdA-4u48A:
12.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4u90 GEPHYRIN

(Rattus
norvegicus) 		PF00994
(MoCF_biosynth)
PF03453
(MoeA_N)
PF03454
(MoeA_C) 		3 ARG A 660
GLY A 725
GLU A 726
 None
 0.30A 6fgdA-4u90A:
50.7		 6fgdA-4u90A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uj6 SURFACE LAYER
PROTEIN

(Geobacillus
stearothermophilus) 		PF13205
(Big_5) 		3 ARG A 120
GLY A 117
GLU A 118
 None
 0.62A 6fgdA-4uj6A:
undetectable		 6fgdA-4uj6A:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wjb PUTATIVE
AMIDOHYDROLASE/PEPTI
DASE

(Burkholderia
cenocepacia) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		3 ARG A  97
GLY A  32
GLU A 389
 None
 0.62A 6fgdA-4wjbA:
undetectable		 6fgdA-4wjbA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xmp LIGHT CHAIN OF
ANTIBODY VRC08

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		3 ARG L  77
GLY L  16
GLU L  17
 None
 0.61A 6fgdA-4xmpL:
undetectable		 6fgdA-4xmpL:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yub NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE

(Homo sapiens) 		no annotation 3 ARG A 466
GLY A 449
GLU A 451
 None
 0.50A 6fgdA-4yubA:
undetectable		 6fgdA-4yubA:
24.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zmu DIGUANYLATE CYCLASE

(Pseudomonas
aeruginosa) 		PF00990
(GGDEF)
PF01590
(GAF) 		3 ARG A 258
GLY A 261
GLU A 262
 None
 0.45A 6fgdA-4zmuA:
undetectable		 6fgdA-4zmuA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ajz 6-PHOSPHOFRUCTO-2-KI
NASE/FRUCTOSE-2,6-BI
SPHOSPHATASE 3

(Homo sapiens) 		PF00300
(His_Phos_1)
PF01591
(6PF2K) 		3 ARG A  74
GLY A  71
GLU A  72
 None
 0.54A 6fgdA-5ajzA:
undetectable		 6fgdA-5ajzA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bp1 MYCOCEROSIC ACID
SYNTHASE

(Mycolicibacterium
smegmatis) 		PF00109
(ketoacyl-synt)
PF00698
(Acyl_transf_1)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		3 ARG A 252
GLY A 195
GLU A 196
 None
 0.54A 6fgdA-5bp1A:
undetectable		 6fgdA-5bp1A:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bw4 16S RRNA
(ADENINE(1408)-N(1))
-METHYLTRANSFERASE

(Catenulispora
acidiphila) 		no annotation 3 ARG A 177
GLY A 123
GLU A 124
 None
 0.53A 6fgdA-5bw4A:
2.7		 6fgdA-5bw4A:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dlb CHAPERONE ESPG3

(Mycobacterium
marinum) 		PF14011
(ESX-1_EspG) 		3 ARG A 249
GLY A 253
GLU A 254
 None
 0.43A 6fgdA-5dlbA:
undetectable		 6fgdA-5dlbA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eu0 ANTITOXIN 1

(Bartonella
rochalimae) 		no annotation 3 ARG B  19
GLY B  51
GLU B  52
 None
 0.51A 6fgdA-5eu0B:
undetectable		 6fgdA-5eu0B:
10.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5euh PUTATIVE GGDEF
DOMAIN MEMBRANE
PROTEIN

(Pseudomonas
fluorescens) 		PF00990
(GGDEF) 		3 ARG A 417
GLY A 420
GLU A 421
 None
 0.62A 6fgdA-5euhA:
undetectable		 6fgdA-5euhA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gnw BLR0248 PROTEIN

(Bradyrhizobium
diazoefficiens) 		no annotation 3 ARG C  15
GLY C  10
GLU C  11
 None
 0.54A 6fgdA-5gnwC:
undetectable		 6fgdA-5gnwC:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h80 CARBOXYLASE

(Deinococcus
radiodurans) 		PF00289
(Biotin_carb_N)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		3 ARG A 267
GLY A 316
GLU A 317
 None
 0.61A 6fgdA-5h80A:
4.6		 6fgdA-5h80A:
23.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ja4 TONSOKU-LIKE PROTEIN

(Homo sapiens) 		PF12796
(Ank_2) 		3 ARG D 525
GLY D 529
GLU D 530
 None
 0.63A 6fgdA-5ja4D:
undetectable		 6fgdA-5ja4D:
16.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m9o STAPHYLOCOCCAL
NUCLEASE
DOMAIN-CONTAINING
PROTEIN 1

(Homo sapiens) 		PF00565
(SNase)
PF00567
(TUDOR) 		3 ARG A 749
GLY A 733
GLU A 734
 None
 0.48A 6fgdA-5m9oA:
undetectable		 6fgdA-5m9oA:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5osn CAPSID PROTEIN

(Enterovirus E) 		PF00073
(Rhv) 		3 ARG A  99
GLY A  93
GLU A  94
 None
 0.54A 6fgdA-5osnA:
undetectable		 6fgdA-5osnA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ta1 GLYCOSIDE HYDROLASE

(Bacteroides
uniformis) 		no annotation 3 ARG A 391
GLY A 400
GLU A 401
 None
 0.57A 6fgdA-5ta1A:
undetectable		 6fgdA-5ta1A:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uhe DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA'

(Mycobacterium
tuberculosis) 		PF00623
(RNA_pol_Rpb1_2)
PF04983
(RNA_pol_Rpb1_3)
PF04997
(RNA_pol_Rpb1_1)
PF04998
(RNA_pol_Rpb1_5)
PF05000
(RNA_pol_Rpb1_4) 		3 ARG D 173
GLY D 201
GLU D 202
 None
 0.55A 6fgdA-5uheD:
undetectable		 6fgdA-5uheD:
15.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6egt GLYCOPROTEIN

(Rift Valley
fever
phlebovirus) 		no annotation 3 ARG A 933
GLY A 930
GLU A 931
 None
 0.57A 6fgdA-6egtA:
undetectable		 6fgdA-6egtA:
21.73