SIMILAR PATTERNS OF AMINO ACIDS FOR 6FGD_A_ACTA817

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a4e CATALASE A

(Saccharomyces
cerevisiae) 		PF00199
(Catalase)
PF06628
(Catalase-rel) 		3 THR A 202
ALA A 247
LYS A 249
 None
 0.66A 6fgdA-1a4eA:
undetectable		 6fgdA-1a4eA:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a59 CITRATE SYNTHASE

(Antarctic
bacterium
DS2-3R) 		PF00285
(Citrate_synt) 		3 THR A 194
ALA A 215
LYS A 217
 None
 0.68A 6fgdA-1a59A:
undetectable		 6fgdA-1a59A:
24.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eb6 NEUTRAL PROTEASE II

(Aspergillus
oryzae) 		PF02102
(Peptidase_M35) 		3 THR A 126
ALA A  21
LYS A  23
 None
 0.76A 6fgdA-1eb6A:
undetectable		 6fgdA-1eb6A:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fbw ENDO-1,4-BETA-GLUCAN
ASE F

([Clostridium]
cellulolyticum) 		PF02011
(Glyco_hydro_48) 		3 THR A 239
ALA A 260
LYS A 262
 None
 0.48A 6fgdA-1fbwA:
undetectable		 6fgdA-1fbwA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fs2 SKP2

(Homo sapiens) 		PF12937
(F-box-like) 		3 THR A 262
ALA A 239
LYS A 240
 None
 0.76A 6fgdA-1fs2A:
0.3		 6fgdA-1fs2A:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gv3 MANGANESE SUPEROXIDE
DISMUTASE

(Nostoc sp. PCC
7120) 		PF00081
(Sod_Fe_N)
PF02777
(Sod_Fe_C) 		3 THR A 106
ALA A  77
LYS A  79
 None
 0.61A 6fgdA-1gv3A:
undetectable		 6fgdA-1gv3A:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iba GLUCOSE PERMEASE

(Escherichia
coli) 		PF00367
(PTS_EIIB) 		3 THR A  75
ALA A  60
LYS A  55
 None
 0.70A 6fgdA-1ibaA:
undetectable		 6fgdA-1ibaA:
13.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jsw L-ASPARTATE
AMMONIA-LYASE

(Escherichia
coli) 		PF00206
(Lyase_1)
PF10415
(FumaraseC_C) 		3 THR A 221
ALA A 283
LYS A 285
 None
 0.72A 6fgdA-1jswA:
0.0		 6fgdA-1jswA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1los OROTIDINE
MONOPHOSPHATE
DECARBOXYLASE

(Methanothermobacter
thermautotrophicus) 		PF00215
(OMPdecase) 		3 THR A  87
ALA A  69
LYS A  42
 None
None
UP6  A5001 (-2.8A)
 0.62A 6fgdA-1losA:
undetectable		 6fgdA-1losA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m9i ANNEXIN VI

(Homo sapiens) 		PF00191
(Annexin) 		3 THR A 385
ALA A 375
LYS A 377
 None
 0.47A 6fgdA-1m9iA:
0.0		 6fgdA-1m9iA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pca PROCARBOXYPEPTIDASE
A PCPA

(Sus scrofa) 		PF00246
(Peptidase_M14)
PF02244
(Propep_M14) 		3 THR A 299
ALA A 229
LYS A 231
 None
 0.71A 6fgdA-1pcaA:
2.4		 6fgdA-1pcaA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vdk FUMARATE HYDRATASE
CLASS II

(Thermus
thermophilus) 		PF00206
(Lyase_1)
PF10415
(FumaraseC_C) 		3 THR A 211
ALA A 287
LYS A 290
 None
 0.75A 6fgdA-1vdkA:
undetectable		 6fgdA-1vdkA:
24.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yii ANNEXIN A5

(Gallus gallus) 		PF00191
(Annexin) 		3 THR A 111
ALA A 239
LYS A 242
 None
 0.76A 6fgdA-1yiiA:
undetectable		 6fgdA-1yiiA:
24.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zn6 PHAGE-RELATED
CONSERVED
HYPOTHETICAL PROTEIN

(Bordetella
bronchiseptica) 		PF02586
(SRAP) 		3 THR A  69
ALA A  77
LYS A  79
 None
 0.71A 6fgdA-1zn6A:
undetectable		 6fgdA-1zn6A:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d07 G/T
MISMATCH-SPECIFIC
THYMINE DNA
GLYCOSYLASE

(Homo sapiens) 		PF03167
(UDG) 		3 THR A 196
ALA A 146
LYS A 148
 None
 0.68A 6fgdA-2d07A:
4.9		 6fgdA-2d07A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e54 ACETYLORNITHINE
AMINOTRANSFERASE

(Thermotoga
maritima) 		PF00202
(Aminotran_3) 		3 THR A 281
ALA A  52
LYS A  54
 None
 0.47A 6fgdA-2e54A:
undetectable		 6fgdA-2e54A:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f8t ARGONAUTE PROTEIN

(Aquifex
aeolicus) 		PF02171
(Piwi) 		3 THR A 544
ALA A 581
LYS A 583
 None
 0.67A 6fgdA-2f8tA:
6.7		 6fgdA-2f8tA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fc3 50S RIBOSOMAL
PROTEIN L7AE

(Aeropyrum
pernix) 		PF01248
(Ribosomal_L7Ae) 		3 THR A  36
ALA A  97
LYS A  83
 None
 0.70A 6fgdA-2fc3A:
undetectable		 6fgdA-2fc3A:
15.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jg2 SERINE
PALMITOYLTRANSFERASE

(Sphingomonas
paucimobilis) 		PF00155
(Aminotran_1_2) 		3 THR A 307
ALA A  87
LYS A  89
 None
 0.64A 6fgdA-2jg2A:
2.2		 6fgdA-2jg2A:
24.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jrb ORF 1 PROTEIN

(Mus musculus) 		PF17490
(Tnp_22_dsRBD) 		3 THR A 293
ALA A 320
LYS A 321
 None
 0.71A 6fgdA-2jrbA:
undetectable		 6fgdA-2jrbA:
11.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mpo MIC2-ASSOCIATED
PROTEIN

(Toxoplasma
gondii) 		no annotation 3 THR A 170
ALA A 165
LYS A  26
 None
 0.76A 6fgdA-2mpoA:
undetectable		 6fgdA-2mpoA:
19.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2obm ESCN

(Escherichia
coli) 		PF00006
(ATP-synt_ab) 		3 THR A 389
ALA A 413
LYS A 415
 None
 0.61A 6fgdA-2obmA:
undetectable		 6fgdA-2obmA:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qh9 UPF0215 PROTEIN
AF_1433

(Archaeoglobus
fulgidus) 		PF01949
(DUF99) 		3 THR A 137
ALA A 145
LYS A 147
 None
 0.60A 6fgdA-2qh9A:
undetectable		 6fgdA-2qh9A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qlt (DL)-GLYCEROL-3-PHOS
PHATASE 1

(Saccharomyces
cerevisiae) 		PF13419
(HAD_2) 		3 THR A 136
ALA A 143
LYS A 145
 SO4  A 280 (-3.7A)
None
None
 0.73A 6fgdA-2qltA:
undetectable		 6fgdA-2qltA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rbc SUGAR KINASE

(Agrobacterium
fabrum) 		PF00294
(PfkB) 		3 THR A 241
ALA A 282
LYS A 284
 EDO  A 331 ( 4.0A)
None
None
 0.68A 6fgdA-2rbcA:
2.6		 6fgdA-2rbcA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vha PERIPLASMIC BINDING
TRANSPORT PROTEIN

(Shigella
flexneri) 		PF00497
(SBP_bac_3) 		3 THR A 229
ALA A  53
LYS A  55
 None
 0.62A 6fgdA-2vhaA:
2.5		 6fgdA-2vhaA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wq9 RETINOL-BINDING
PROTEIN 4

(Homo sapiens) 		PF00061
(Lipocalin) 		3 THR A 113
ALA A 148
LYS A 150
 None
None
CL  A1174 (-4.3A)
 0.45A 6fgdA-2wq9A:
undetectable		 6fgdA-2wq9A:
17.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x1m METHIONYL-TRNA
SYNTHETASE

(Mycolicibacterium
smegmatis) 		PF09334
(tRNA-synt_1g) 		3 THR A 239
ALA A 103
LYS A 105
 None
 0.70A 6fgdA-2x1mA:
2.6		 6fgdA-2x1mA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x24 ACETYL-COA
CARBOXYLASE

(Bos taurus) 		PF01039
(Carboxyl_trans) 		3 THR A 409
ALA A 465
LYS A 467
 None
 0.59A 6fgdA-2x24A:
undetectable		 6fgdA-2x24A:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x8u SERINE
PALMITOYLTRANSFERASE

(Sphingomonas
wittichii) 		PF00155
(Aminotran_1_2) 		3 THR A 287
ALA A  67
LYS A  69
 None
 0.61A 6fgdA-2x8uA:
2.3		 6fgdA-2x8uA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xuz IRON-UPTAKE
SYSTEM-BINDING
PROTEIN

(Bacillus
subtilis) 		PF01497
(Peripla_BP_2) 		3 THR A 161
ALA A 292
LYS A 294
 None
None
PEG  A1303 ( 3.7A)
 0.66A 6fgdA-2xuzA:
3.6		 6fgdA-2xuzA:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aat ASPARTATE
AMINOTRANSFERASE

(Escherichia
coli) 		PF00155
(Aminotran_1_2) 		3 THR A 271
ALA A 100
LYS A  98
 None
 0.65A 6fgdA-3aatA:
2.2		 6fgdA-3aatA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmg PUTATIVE
BETA-GALACTOSIDASE

(Bacteroides
fragilis) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF16355
(DUF4982) 		3 THR A 632
ALA A 637
LYS A 648
 None
 0.75A 6fgdA-3cmgA:
undetectable		 6fgdA-3cmgA:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ctz XAA-PRO
AMINOPEPTIDASE 1

(Homo sapiens) 		PF00557
(Peptidase_M24)
PF01321
(Creatinase_N)
PF16188
(Peptidase_M24_C)
PF16189
(Creatinase_N_2) 		3 THR A  74
ALA A  82
LYS A  84
 None
 0.68A 6fgdA-3ctzA:
undetectable		 6fgdA-3ctzA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d6n ASPARTATE
CARBAMOYLTRANSFERASE

(Aquifex
aeolicus) 		PF00185
(OTCace)
PF02729
(OTCace_N) 		3 THR B  63
ALA B  56
LYS B 283
 None
 0.74A 6fgdA-3d6nB:
5.1		 6fgdA-3d6nB:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e6e ALANINE RACEMASE

(Enterococcus
faecalis) 		PF00842
(Ala_racemase_C)
PF01168
(Ala_racemase_N) 		3 THR A  15
ALA A  54
LYS A  56
 None
 0.71A 6fgdA-3e6eA:
undetectable		 6fgdA-3e6eA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f2b DNA-DIRECTED DNA
POLYMERASE III ALPHA
CHAIN

(Geobacillus
kaustophilus) 		PF02811
(PHP)
PF07733
(DNA_pol3_alpha)
PF14579
(HHH_6) 		3 THR A 361
ALA A 392
LYS A 394
 None
 0.76A 6fgdA-3f2bA:
undetectable		 6fgdA-3f2bA:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fca CYSTEINE SYNTHASE

(Thermus
thermophilus) 		PF00291
(PALP) 		3 THR A 278
ALA A 263
LYS A 265
 HQA  A  22 ( 4.6A)
None
None
 0.68A 6fgdA-3fcaA:
undetectable		 6fgdA-3fcaA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ff6 ACETYL-COA
CARBOXYLASE 2

(Homo sapiens) 		PF01039
(Carboxyl_trans) 		3 THR A2084
ALA A2140
LYS A2142
 None
 0.51A 6fgdA-3ff6A:
undetectable		 6fgdA-3ff6A:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3flu DIHYDRODIPICOLINATE
SYNTHASE

(Neisseria
meningitidis) 		PF00701
(DHDPS) 		3 THR A 242
ALA A 284
LYS A 286
 None
 0.65A 6fgdA-3fluA:
undetectable		 6fgdA-3fluA:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fyq CG6831-PA (TALIN)

(Drosophila
melanogaster) 		no annotation 3 THR A2140
ALA A2092
LYS A2094
 None
 0.58A 6fgdA-3fyqA:
undetectable		 6fgdA-3fyqA:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3goc ENDONUCLEASE V

(Streptomyces
avermitilis) 		PF04493
(Endonuclease_5) 		3 THR A  75
ALA A 223
LYS A 225
 None
 0.51A 6fgdA-3gocA:
undetectable		 6fgdA-3gocA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ilv GLUTAMINE-DEPENDENT
NAD(+) SYNTHETASE

(Cytophaga
hutchinsonii) 		PF00795
(CN_hydrolase)
PF02540
(NAD_synthase) 		3 THR A 371
ALA A 396
LYS A 362
 None
 0.75A 6fgdA-3ilvA:
2.7		 6fgdA-3ilvA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3im9 MALONYL COA-ACYL
CARRIER PROTEIN
TRANSACYLASE

(Staphylococcus
aureus) 		PF00698
(Acyl_transf_1) 		3 THR A  68
ALA A  36
LYS A  38
 None
 0.74A 6fgdA-3im9A:
undetectable		 6fgdA-3im9A:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ira CONSERVED PROTEIN

(Methanosarcina
mazei) 		PF03190
(Thioredox_DsbH) 		3 THR A 111
ALA A 156
LYS A 158
 None
 0.77A 6fgdA-3iraA:
undetectable		 6fgdA-3iraA:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ksd GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
1

(Staphylococcus
aureus) 		no annotation 3 THR Q 152
ALA Q 213
LYS Q 215
 None
 0.76A 6fgdA-3ksdQ:
4.1		 6fgdA-3ksdQ:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nda SERPIN-2

(Ixodes ricinus) 		PF00079
(Serpin) 		3 THR A 178
ALA A 207
LYS A 267
 None
 0.75A 6fgdA-3ndaA:
undetectable		 6fgdA-3ndaA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oxh RV0577 PROTEIN

(Mycobacterium
tuberculosis) 		PF00903
(Glyoxalase) 		3 THR A  19
ALA A  25
LYS A  27
 None
 0.72A 6fgdA-3oxhA:
undetectable		 6fgdA-3oxhA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3phf ENVELOPE
GLYCOPROTEIN H

(Human
gammaherpesvirus
4) 		no annotation 3 THR A 551
ALA A 531
LYS A 533
 None
 0.62A 6fgdA-3phfA:
undetectable		 6fgdA-3phfA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pzu ENDOGLUCANASE

(Bacillus
subtilis) 		PF00150
(Cellulase) 		3 THR A 285
ALA A  56
LYS A  55
 None
 0.67A 6fgdA-3pzuA:
undetectable		 6fgdA-3pzuA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qdk RIBULOKINASE

(Bacillus
halodurans) 		PF00370
(FGGY_N)
PF02782
(FGGY_C) 		3 THR A 285
ALA A 503
LYS A 505
 None
 0.74A 6fgdA-3qdkA:
undetectable		 6fgdA-3qdkA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3quf EXTRACELLULAR
SOLUTE-BINDING
PROTEIN, FAMILY 1

(Bifidobacterium
longum) 		PF13416
(SBP_bac_8) 		3 THR A  39
ALA A 325
LYS A 327
 None
 0.49A 6fgdA-3qufA:
undetectable		 6fgdA-3qufA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3trj PHOSPHOHEPTOSE
ISOMERASE

(Francisella
tularensis) 		PF13580
(SIS_2) 		3 THR A  62
ALA A  78
LYS A  45
 None
 0.76A 6fgdA-3trjA:
3.8		 6fgdA-3trjA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u1k POLYRIBONUCLEOTIDE
NUCLEOTIDYLTRANSFERA
SE 1, MITOCHONDRIAL

(Homo sapiens) 		PF00013
(KH_1)
PF01138
(RNase_PH)
PF03725
(RNase_PH_C)
PF03726
(PNPase) 		3 THR A 531
ALA A 581
LYS A 583
 None
 0.62A 6fgdA-3u1kA:
undetectable		 6fgdA-3u1kA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zzu ELONGATION FACTOR G

(Staphylococcus
aureus) 		PF00009
(GTP_EFTU)
PF00679
(EFG_C)
PF03144
(GTP_EFTU_D2)
PF03764
(EFG_IV)
PF14492
(EFG_II) 		3 THR A  25
ALA A 261
LYS A 265
 None
 0.71A 6fgdA-3zzuA:
1.9		 6fgdA-3zzuA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4as5 INOSITOL
MONOPHOSPHATASE 1

(Mus musculus) 		PF00459
(Inositol_P) 		3 THR A  46
ALA A  26
LYS A  28
 EDO  A1280 (-3.5A)
EDO  A1280 ( 3.7A)
None
 0.73A 6fgdA-4as5A:
2.4		 6fgdA-4as5A:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4az7 BETA-N-ACETYLHEXOSAM
INIDASE

(Streptococcus
pneumoniae) 		PF00728
(Glyco_hydro_20) 		3 THR A 606
ALA A 577
LYS A 579
 None
 0.71A 6fgdA-4az7A:
undetectable		 6fgdA-4az7A:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c5f MEMBRANE-BOUND LYTIC
MUREIN
TRANSGLYCOSYLASE C

(Escherichia
coli) 		PF01464
(SLT)
PF11873
(DUF3393) 		3 THR A 216
ALA A 352
LYS A 354
 None
 0.76A 6fgdA-4c5fA:
undetectable		 6fgdA-4c5fA:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dhe PROBABLE GTP-BINDING
PROTEIN ENGB

(Burkholderia
thailandensis) 		PF01926
(MMR_HSR1) 		3 THR A  40
ALA A 188
LYS A 190
 None
CL  A 302 (-3.5A)
None
 0.60A 6fgdA-4dheA:
2.1		 6fgdA-4dheA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4el8 GLYCOSIDE HYDROLASE
FAMILY 48

(Caldicellulosiruptor
bescii) 		PF02011
(Glyco_hydro_48) 		3 THR A 235
ALA A 258
LYS A 260
 None
 0.56A 6fgdA-4el8A:
undetectable		 6fgdA-4el8A:
19.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hdt 3-HYDROXYISOBUTYRYL-
COA HYDROLASE

(Mycolicibacterium
thermoresistibile) 		PF16113
(ECH_2) 		3 THR A 151
ALA A 276
LYS A 278
 None
 0.69A 6fgdA-4hdtA:
undetectable		 6fgdA-4hdtA:
24.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hwv PECTATE LYASE/AMB
ALLERGEN

(Acidovorax
citrulli) 		PF00544
(Pec_lyase_C) 		3 THR A 215
ALA A 494
LYS A 496
 None
 0.76A 6fgdA-4hwvA:
undetectable		 6fgdA-4hwvA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4luj OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE

(Methanocaldococcus
jannaschii) 		PF00215
(OMPdecase) 		3 THR A  96
ALA A  78
LYS A  51
 None
None
BMP  A 301 (-2.8A)
 0.54A 6fgdA-4lujA:
undetectable		 6fgdA-4lujA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n0i GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A,
MITOCHONDRIAL

(Saccharomyces
cerevisiae) 		PF01425
(Amidase) 		3 THR A 287
ALA A 354
LYS A 356
 None
 0.49A 6fgdA-4n0iA:
undetectable		 6fgdA-4n0iA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nqy ISOPROPYLMALATE/CITR
AMALATE ISOMERASE
LARGE SUBUNIT

(Methanocaldococcus
jannaschii) 		PF00330
(Aconitase) 		3 THR A 201
ALA A 269
LYS A 271
 None
 0.69A 6fgdA-4nqyA:
undetectable		 6fgdA-4nqyA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ntd THIOREDOXIN
REDUCTASE

(Streptomyces
clavuligerus) 		PF07992
(Pyr_redox_2) 		3 THR A  99
ALA A 107
LYS A   1
 None
 0.62A 6fgdA-4ntdA:
5.1		 6fgdA-4ntdA:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p29 LPOA

(Haemophilus
influenzae) 		PF04348
(LppC) 		3 THR A 140
ALA A 109
LYS A 111
 None
 0.61A 6fgdA-4p29A:
undetectable		 6fgdA-4p29A:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p3m SERINE
HYDROXYMETHYLTRANSFE
RASE

(Psychromonas
ingrahamii) 		PF00464
(SHMT) 		3 THR A 402
ALA A 392
LYS A 394
 GOL  A 510 ( 4.0A)
None
None
 0.49A 6fgdA-4p3mA:
undetectable		 6fgdA-4p3mA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pdd TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT

(Polaromonas sp.
JS666) 		PF03480
(DctP) 		3 THR A  53
ALA A 273
LYS A 276
 None
 0.60A 6fgdA-4pddA:
2.3		 6fgdA-4pddA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qav 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2

(Neisseria
meningitidis) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		3 THR A 407
ALA A 286
LYS A 288
 None
 0.68A 6fgdA-4qavA:
undetectable		 6fgdA-4qavA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qme AMINOPEPTIDASE N

(Neisseria
meningitidis) 		PF01433
(Peptidase_M1)
PF11940
(DUF3458)
PF17432
(DUF3458_C) 		3 THR A 725
ALA A 698
LYS A 700
 None
 0.75A 6fgdA-4qmeA:
2.4		 6fgdA-4qmeA:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rh7 GREEN FLUORESCENT
PROTEIN/CYTOPLASMIC
DYNEIN 2 HEAVY CHAIN
1

(Homo sapiens;
synthetic
construct) 		PF03028
(Dynein_heavy)
PF07728
(AAA_5)
PF08393
(DHC_N2)
PF12774
(AAA_6)
PF12775
(AAA_7)
PF12777
(MT)
PF12780
(AAA_8)
PF12781
(AAA_9) 		3 THR A1999
ALA A1942
LYS A1944
 None
 0.58A 6fgdA-4rh7A:
undetectable		 6fgdA-4rh7A:
8.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4u90 GEPHYRIN

(Rattus
norvegicus) 		PF00994
(MoCF_biosynth)
PF03453
(MoeA_N)
PF03454
(MoeA_C) 		3 THR A 342
ALA A 356
LYS A 473
 None
 0.15A 6fgdA-4u90A:
50.7		 6fgdA-4u90A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uwm 3,6-DIKETOCAMPHANE
1,6 MONOOXYGENASE

(Pseudomonas
putida) 		PF00296
(Bac_luciferase) 		3 THR A   5
ALA A 370
LYS A 372
 None
 0.72A 6fgdA-4uwmA:
undetectable		 6fgdA-4uwmA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wct FRUCTOSYL
AMINE:OXYGEN
OXIDOREDUCTASE

(Aspergillus
fumigatus) 		PF01266
(DAO) 		3 THR A 379
ALA A  85
LYS A  87
 None
 0.47A 6fgdA-4wctA:
2.1		 6fgdA-4wctA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xgc ORIGIN RECOGNITION
COMPLEX SUBUNIT 4

(Drosophila
melanogaster) 		PF13191
(AAA_16)
PF14629
(ORC4_C) 		3 THR D 281
ALA D 321
LYS D 323
 None
 0.76A 6fgdA-4xgcD:
undetectable		 6fgdA-4xgcD:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b37 TRYPTOPHAN
DEHYDROGENASE

(Nostoc
punctiforme) 		PF00208
(ELFV_dehydrog)
PF02812
(ELFV_dehydrog_N) 		3 THR A 327
ALA A 271
LYS A 273
 None
 0.76A 6fgdA-5b37A:
3.6		 6fgdA-5b37A:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c2i ALR1585 PROTEIN

(Nostoc sp. PCC
7120) 		PF04261
(Dyp_perox) 		3 THR A 346
ALA A 354
LYS A 356
 None
 0.35A 6fgdA-5c2iA:
undetectable		 6fgdA-5c2iA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dgq PUTATIVE
ENDOGLUCANASE-RELATE
D PROTEIN

(Photobacterium
profundum) 		PF00759
(Glyco_hydro_9) 		3 THR A 223
ALA A 118
LYS A 120
 None
 0.62A 6fgdA-5dgqA:
undetectable		 6fgdA-5dgqA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dmq REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H P80

(Murine leukemia
virus) 		PF00075
(RNase_H)
PF00078
(RVT_1) 		3 THR A 523
ALA A 569
LYS A 571
 None
 0.72A 6fgdA-5dmqA:
undetectable		 6fgdA-5dmqA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e6p PLEXIN-B2

(Mus musculus) 		PF08337
(Plexin_cytopl) 		3 THR A1490
ALA A1443
LYS A1446
 None
 0.69A 6fgdA-5e6pA:
undetectable		 6fgdA-5e6pA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gin 50S RIBOSOMAL
PROTEIN L7AE

(Sulfolobus
solfataricus) 		PF01248
(Ribosomal_L7Ae) 		3 THR C  39
ALA C 100
LYS C  86
 U  H  11 ( 3.5A)
U  H  11 ( 3.7A)
U  H  11 ( 3.9A)
 0.76A 6fgdA-5ginC:
undetectable		 6fgdA-5ginC:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gnw BLR0248 PROTEIN

(Bradyrhizobium
diazoefficiens) 		no annotation 3 THR C  95
ALA C 145
LYS C 147
 None
 0.39A 6fgdA-5gnwC:
3.2		 6fgdA-5gnwC:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kzh BETA-LACTAMASE

(Acinetobacter
baumannii) 		PF00905
(Transpeptidase) 		3 THR A 232
ALA A 182
LYS A 184
 None
 0.74A 6fgdA-5kzhA:
undetectable		 6fgdA-5kzhA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5llt NICOTINATE-NUCLEOTID
E
ADENYLYLTRANSFERASE

(Plasmodium
falciparum) 		PF01467
(CTP_transf_like) 		3 THR A  17
ALA A 171
LYS A 173
 None
 0.77A 6fgdA-5lltA:
2.5		 6fgdA-5lltA:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mtz RIBONUCLEASE Z

(Saccharomyces
cerevisiae) 		PF13691
(Lactamase_B_4) 		3 THR A 739
ALA A 732
LYS A 734
 None
 0.50A 6fgdA-5mtzA:
undetectable		 6fgdA-5mtzA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mz8 ALDEHYDE
DEHYDROGENASE 21

(Physcomitrella
patens) 		PF00171
(Aldedh) 		3 THR A 122
ALA A 178
LYS A 180
 None
 0.75A 6fgdA-5mz8A:
2.8		 6fgdA-5mz8A:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n7f MEMBRANE-ASSOCIATED
GUANYLATE KINASE, WW
AND PDZ
DOMAIN-CONTAINING
PROTEIN 1,ANNEXIN A2

(Homo sapiens) 		no annotation 3 THR A 594
ALA A 584
LYS A 586
 None
 0.71A 6fgdA-5n7fA:
undetectable		 6fgdA-5n7fA:
24.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oas MALATE SYNTHASE G

(Pseudomonas
aeruginosa) 		no annotation 3 THR A   2
ALA A 282
LYS A 285
 None
 0.72A 6fgdA-5oasA:
undetectable		 6fgdA-5oasA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oqp CONDENSIN COMPLEX
SUBUNIT 3

(Saccharomyces
cerevisiae) 		no annotation 3 THR A 574
ALA A 570
LYS A 568
 None
 0.76A 6fgdA-5oqpA:
undetectable		 6fgdA-5oqpA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t8t S-ADENOSYLMETHIONINE
SYNTHASE

(Neisseria
gonorrhoeae) 		PF00438
(S-AdoMet_synt_N)
PF02772
(S-AdoMet_synt_M)
PF02773
(S-AdoMet_synt_C) 		3 THR A 377
ALA A 380
LYS A 384
 None
 0.76A 6fgdA-5t8tA:
undetectable		 6fgdA-5t8tA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t98 GLYCOSIDE HYDROLASE

(Bacteroides
uniformis) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF16355
(DUF4982) 		3 THR A 658
ALA A 663
LYS A 674
 None
 0.76A 6fgdA-5t98A:
undetectable		 6fgdA-5t98A:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vat PENICILLIN-BINDING
PROTEIN ACTIVATOR
LPOA

(Haemophilus
influenzae) 		PF04348
(LppC) 		3 THR A 140
ALA A 109
LYS A 111
 None
 0.69A 6fgdA-5vatA:
5.1		 6fgdA-5vatA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vfd BETA-LACTAMASE

(Acinetobacter
baumannii) 		PF00905
(Transpeptidase) 		3 THR A  65
ALA A  73
LYS A  75
 None
 0.70A 6fgdA-5vfdA:
undetectable		 6fgdA-5vfdA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xa2 CYSTEINE SYNTHASE

(Planctopirus
limnophila) 		PF00291
(PALP) 		3 THR A 290
ALA A 274
LYS A 276
 None
 0.68A 6fgdA-5xa2A:
undetectable		 6fgdA-5xa2A:
24.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xey PHLORETIN HYDROLASE

(Mycobacteroides
abscessus) 		no annotation 3 THR A  85
ALA A  54
LYS A  56
 None
 0.74A 6fgdA-5xeyA:
undetectable		 6fgdA-5xeyA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y3r DNA-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT

(Homo sapiens) 		PF00454
(PI3_PI4_kinase)
PF02259
(FAT)
PF02260
(FATC)
PF08163
(NUC194) 		3 THR C1346
ALA C1405
LYS C1407
 None
 0.63A 6fgdA-5y3rC:
undetectable		 6fgdA-5y3rC:
6.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ax8 METHIONINE-TRNA
LIGASE

(Mycobacterium
tuberculosis) 		no annotation 3 THR A 237
ALA A 102
LYS A 104
 None
 0.63A 6fgdA-6ax8A:
2.5		 6fgdA-6ax8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f74 ALCOHOL OXIDASE

(Thermothelomyces
thermophila) 		no annotation 3 THR A 312
ALA A 385
LYS A 387
 None
 0.71A 6fgdA-6f74A:
undetectable		 6fgdA-6f74A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fuy VINCULIN

(Homo sapiens) 		no annotation 3 THR A 215
ALA A 226
LYS A 228
 None
 0.68A 6fgdA-6fuyA:
undetectable		 6fgdA-6fuyA:
undetectable