SIMILAR PATTERNS OF AMINO ACIDS FOR 6FGD_A_ACTA810_0
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1a04 | NITRATE/NITRITERESPONSE REGULATORPROTEIN NARL (Escherichiacoli) |
PF00072(Response_reg)PF00196(GerE) | 3 | LEU A 180LEU A 166ARG A 179 | None | 0.68A | 6fgdA-1a04A:3.8 | 6fgdA-1a04A:19.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1et6 | SUPERANTIGEN SMEZ-2 (Streptococcuspyogenes) |
PF01123(Stap_Strp_toxin)PF02876(Stap_Strp_tox_C) | 3 | LEU A 141LEU A 174ARG A 138 | None | 0.65A | 6fgdA-1et6A:undetectable | 6fgdA-1et6A:18.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1et9 | SUPERANTIGEN SPE-H (Streptococcuspyogenes) |
PF01123(Stap_Strp_toxin)PF02876(Stap_Strp_tox_C) | 3 | LEU A 138LEU A 171ARG A 135 | None | 0.61A | 6fgdA-1et9A:undetectable | 6fgdA-1et9A:18.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1fcu | HYALURONOGLUCOSAMINIDASE (Apis mellifera) |
PF01630(Glyco_hydro_56) | 3 | LEU A 314LEU A 27ARG A 317 | None | 0.64A | 6fgdA-1fcuA:undetectable | 6fgdA-1fcuA:24.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1kea | POSSIBLE G-TMISMATCHES REPAIRENZYME (Methanothermobacterthermautotrophicus) |
PF00730(HhH-GPD) | 3 | LEU A 134LEU A 187ARG A 30 | None | 0.68A | 6fgdA-1keaA:undetectable | 6fgdA-1keaA:18.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1kej | TERMINALDEOXYNUCLEOTIDYLTRANSFERASE SHORTISOFORM (Mus musculus) |
PF10391(DNA_pol_lambd_f)PF14716(HHH_8)PF14791(DNA_pol_B_thumb)PF14792(DNA_pol_B_palm) | 3 | LEU A 460LEU A 448ARG A 508 | None | 0.51A | 6fgdA-1kejA:2.0 | 6fgdA-1kejA:21.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1m4v | SET3,SUPERANTIGEN-LIKEPROTEIN (Staphylococcusaureus) |
PF02876(Stap_Strp_tox_C)PF09199(SSL_OB) | 3 | LEU A 148LEU A 178ARG A 145 | None | 0.62A | 6fgdA-1m4vA:undetectable | 6fgdA-1m4vA:18.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1nf2 | PHOSPHATASE (Thermotogamaritima) |
PF08282(Hydrolase_3) | 3 | LEU A 198LEU A 72ARG A 201 | None | 0.65A | 6fgdA-1nf2A:0.0 | 6fgdA-1nf2A:19.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1nfp | LUXF GENE PRODUCT (Photobacteriumleiognathi) |
PF00296(Bac_luciferase) | 3 | LEU A 93LEU A 68ARG A 127 | None | 0.49A | 6fgdA-1nfpA:undetectable | 6fgdA-1nfpA:19.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1u0t | INORGANICPOLYPHOSPHATE/ATP-NAD KINASE (Mycobacteriumtuberculosis) |
PF01513(NAD_kinase) | 3 | LEU A 141LEU A 139ARG A 274 | None | 0.66A | 6fgdA-1u0tA:3.4 | 6fgdA-1u0tA:23.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1v1p | EXOTOXIN 1 (Staphylococcusaureus) |
PF02876(Stap_Strp_tox_C)PF09199(SSL_OB) | 3 | LEU A 153LEU A 183ARG A 150 | None | 0.68A | 6fgdA-1v1pA:undetectable | 6fgdA-1v1pA:17.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1vb3 | THREONINE SYNTHASE (Escherichiacoli) |
PF00291(PALP)PF14821(Thr_synth_N) | 3 | LEU A 264LEU A 47ARG A 238 | None | 0.66A | 6fgdA-1vb3A:undetectable | 6fgdA-1vb3A:23.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1vhe | AMINOPEPTIDASE/GLUCANASE HOMOLOG (Bacillussubtilis) |
PF05343(Peptidase_M42) | 3 | LEU A 176LEU A 8ARG A 333 | None | 0.68A | 6fgdA-1vheA:3.7 | 6fgdA-1vheA:23.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1w6f | ARYLAMINEN-ACETYLTRANSFERASE (Mycolicibacteriumsmegmatis) |
PF00797(Acetyltransf_2) | 3 | LEU A 84LEU A 5ARG A 17 | None | 0.58A | 6fgdA-1w6fA:undetectable | 6fgdA-1w6fA:21.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1xee | CHEMOTAXIS-INHIBITING PROTEIN CHIPS (Staphylococcusaureus) |
PF11434(CHIPS) | 3 | LEU A 49LEU A 76ARG A 46 | None | 0.65A | 6fgdA-1xeeA:undetectable | 6fgdA-1xeeA:11.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1zg5 | NITRATE/NITRITERESPONSE REGULATORPROTEIN NARL (Escherichiacoli) |
PF00196(GerE) | 3 | LEU A 180LEU A 166ARG A 179 | None | 0.68A | 6fgdA-1zg5A:undetectable | 6fgdA-1zg5A:10.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2a2f | EXOCYST COMPLEXCOMPONENT SEC15 (Drosophilamelanogaster) |
PF04091(Sec15) | 3 | LEU X 302LEU X 297ARG X 248 | None | 0.66A | 6fgdA-2a2fX:undetectable | 6fgdA-2a2fX:20.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2b7u | CHARYBDIN (Drimia maritima) |
PF00161(RIP) | 3 | LEU A 158LEU A 111ARG A 154 | None | 0.67A | 6fgdA-2b7uA:undetectable | 6fgdA-2b7uA:21.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2dw4 | LYSINE-SPECIFICHISTONE DEMETHYLASE1 (Homo sapiens) |
PF01593(Amino_oxidase)PF04433(SWIRM) | 3 | LEU A 261LEU A 183ARG A 214 | None | 0.54A | 6fgdA-2dw4A:4.8 | 6fgdA-2dw4A:22.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2e6k | TRANSKETOLASE (Thermusthermophilus) |
PF00456(Transketolase_N)PF02779(Transket_pyr)PF02780(Transketolase_C) | 3 | LEU A 335LEU A 338ARG A 503 | None | 0.66A | 6fgdA-2e6kA:4.4 | 6fgdA-2e6kA:22.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2e7a | TUMOR NECROSISFACTOR (Homo sapiens) |
PF00229(TNF) | 3 | LEU A 132LEU A 126ARG A 82 | None | 0.66A | 6fgdA-2e7aA:undetectable | 6fgdA-2e7aA:16.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2fuq | HEPARINASE IIPROTEIN (Pedobacterheparinus) |
PF07940(Hepar_II_III)PF16332(DUF4962) | 3 | LEU A 697LEU A 550ARG A 700 | None | 0.56A | 6fgdA-2fuqA:undetectable | 6fgdA-2fuqA:19.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2g9h | EXTRACELLULARENTEROTOXIN TYPE I (Staphylococcusaureus) |
PF01123(Stap_Strp_toxin)PF02876(Stap_Strp_tox_C) | 3 | LEU D 133LEU D 180ARG D 130 | None | 0.67A | 6fgdA-2g9hD:undetectable | 6fgdA-2g9hD:19.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ihm | DNA POLYMERASE MU (Mus musculus) |
PF10391(DNA_pol_lambd_f)PF14716(HHH_8)PF14791(DNA_pol_B_thumb)PF14792(DNA_pol_B_palm) | 3 | LEU A 446LEU A 434ARG A 494 | None | 0.61A | 6fgdA-2ihmA:undetectable | 6fgdA-2ihmA:22.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2jfd | FATTY ACID SYNTHASE (Homo sapiens) |
PF00698(Acyl_transf_1)PF16197(KAsynt_C_assoc) | 3 | LEU A 513LEU A 793ARG A 512 | None | 0.67A | 6fgdA-2jfdA:undetectable | 6fgdA-2jfdA:21.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2msw | RESPONSEREGULATOR/SENSORHISTIDINE KINASE (Erythrobacterlitoralis) |
PF00072(Response_reg) | 3 | LEU A 72LEU A 45ARG A 75 | None | 0.67A | 6fgdA-2mswA:4.8 | 6fgdA-2mswA:15.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ntt | STAPHYLOCOCCALENTEROTOXIN K (Staphylococcusaureus) |
PF02876(Stap_Strp_tox_C) | 3 | LEU A 133LEU A 180ARG A 130 | None | 0.61A | 6fgdA-2nttA:undetectable | 6fgdA-2nttA:18.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2nx9 | OXALOACETATEDECARBOXYLASE 2,SUBUNIT ALPHA (Vibrio cholerae) |
PF00682(HMGL-like)PF02436(PYC_OADA) | 3 | LEU A 325LEU A 305ARG A 294 | None | 0.55A | 6fgdA-2nx9A:undetectable | 6fgdA-2nx9A:22.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2o74 | OHCU DECARBOXYLASE (Danio rerio) |
PF09349(OHCU_decarbox) | 3 | LEU A 125LEU A 160ARG A 124 | None | 0.53A | 6fgdA-2o74A:undetectable | 6fgdA-2o74A:17.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2r4i | UNCHARACTERIZEDPROTEIN (Cytophagahutchinsonii) |
PF14534(DUF4440) | 3 | LEU A 30LEU A 14ARG A 102 | None | 0.47A | 6fgdA-2r4iA:undetectable | 6fgdA-2r4iA:15.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2r9z | GLUTATHIONE AMIDEREDUCTASE (Marichromatiumgracile) |
PF02852(Pyr_redox_dim)PF07992(Pyr_redox_2) | 3 | LEU A 362LEU A 353ARG A 361 | None | 0.65A | 6fgdA-2r9zA:4.9 | 6fgdA-2r9zA:22.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2rdg | SUPERANTIGEN-LIKEPROTEIN 11 (Staphylococcusaureus) |
PF02876(Stap_Strp_tox_C)PF09199(SSL_OB) | 3 | LEU A 141LEU A 171ARG A 138 | None | 0.58A | 6fgdA-2rdgA:undetectable | 6fgdA-2rdgA:18.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2rjt | BETA-KETOACYL-ACPSYNTHASE II (Streptococcuspneumoniae) |
PF00109(ketoacyl-synt)PF02801(Ketoacyl-synt_C) | 3 | LEU A 96LEU A 91ARG A 249 | None | 0.57A | 6fgdA-2rjtA:undetectable | 6fgdA-2rjtA:20.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2tnf | PROTEIN (TUMORNECROSIS FACTORALPHA) (Mus musculus) |
PF00229(TNF) | 3 | LEU A 132LEU A 126ARG A 82 | None | 0.61A | 6fgdA-2tnfA:undetectable | 6fgdA-2tnfA:17.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2vi7 | ACETYLTRANSFERASEPA1377 (Pseudomonasaeruginosa) |
PF00583(Acetyltransf_1) | 3 | LEU A 61LEU A 59ARG A 12 | None | 0.63A | 6fgdA-2vi7A:2.2 | 6fgdA-2vi7A:19.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2wvl | MANNOSYL-3-PHOSPHOGLYCERATE SYNTHASE (Thermusthermophilus) |
PF09488(Osmo_MPGsynth) | 3 | LEU A 17LEU A 275ARG A 198 | None | 0.60A | 6fgdA-2wvlA:undetectable | 6fgdA-2wvlA:23.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3chl | ALPHA-14 GIARDIN (Giardiaintestinalis) |
PF00191(Annexin) | 3 | LEU A 32LEU A 67ARG A 29 | None | 0.57A | 6fgdA-3chlA:undetectable | 6fgdA-3chlA:20.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3cp8 | TRNA URIDINE5-CARBOXYMETHYLAMINOMETHYL MODIFICATIONENZYME GIDA (Chlorobaculumtepidum) |
PF01134(GIDA)PF13932(GIDA_assoc) | 3 | LEU A 615LEU A 579ARG A 618 | None | 0.63A | 6fgdA-3cp8A:3.4 | 6fgdA-3cp8A:20.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3dao | PUTATIVE PHOSPHATE ([Eubacterium]rectale) |
PF08282(Hydrolase_3) | 3 | LEU A 62LEU A 78ARG A 203 | None | 0.65A | 6fgdA-3daoA:2.4 | 6fgdA-3daoA:22.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3dcf | TRANSCRIPTIONALREGULATOR OF THETETR/ACRR FAMILY (Thermobifidafusca) |
PF00440(TetR_N) | 3 | LEU A 110LEU A 157ARG A 106 | None | 0.59A | 6fgdA-3dcfA:undetectable | 6fgdA-3dcfA:20.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3fsd | NTF2-LIKE PROTEIN OFUNKNOWN FUNCTION INNUTRIENT UPTAKE (Rhodospirillumrubrum) |
PF14534(DUF4440) | 3 | LEU A 38LEU A 22ARG A 111 | None | 0.60A | 6fgdA-3fsdA:undetectable | 6fgdA-3fsdA:17.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hwc | CHLOROPHENOL-4-MONOOXYGENASE COMPONENT 2 (Burkholderiacepacia) |
PF03241(HpaB)PF11794(HpaB_N) | 3 | LEU A3306LEU A3430ARG A3299 | None | 0.50A | 6fgdA-3hwcA:undetectable | 6fgdA-3hwcA:22.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3jc7 | DNA REPLICATIONCOMPLEX GINS PROTEINSLD5 (Saccharomycescerevisiae) |
PF05916(Sld5)PF16922(SLD5_C) | 3 | LEU D 136LEU D 87ARG D 90 | None | 0.63A | 6fgdA-3jc7D:undetectable | 6fgdA-3jc7D:22.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3l3b | ES1 FAMILY PROTEIN (Ehrlichiachaffeensis) |
PF01965(DJ-1_PfpI) | 3 | LEU A 25LEU A 200ARG A 21 | None | 0.52A | 6fgdA-3l3bA:3.3 | 6fgdA-3l3bA:21.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3o13 | SUPERANTIGEN-LIKEPROTEIN (Staphylococcusaureus) |
PF02876(Stap_Strp_tox_C)PF09199(SSL_OB) | 3 | LEU A 172LEU A 202ARG A 169 | None | 0.64A | 6fgdA-3o13A:undetectable | 6fgdA-3o13A:19.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3of4 | NITROREDUCTASE (Idiomarinaloihiensis) |
PF00881(Nitroreductase) | 3 | LEU A 102LEU A 96ARG A 100 | NoneNoneGOL A 317 (-3.0A) | 0.67A | 6fgdA-3of4A:undetectable | 6fgdA-3of4A:17.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3q10 | PANTOATE--BETA-ALANINE LIGASE (Yersinia pestis) |
PF02569(Pantoate_ligase) | 3 | LEU A 254LEU A 282ARG A 220 | None | 0.51A | 6fgdA-3q10A:2.5 | 6fgdA-3q10A:23.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3q98 | TRANSCARBAMYLASE (Escherichiacoli) |
PF00185(OTCace)PF02729(OTCace_N) | 3 | LEU A 293LEU A 285ARG A 281 | None | 0.57A | 6fgdA-3q98A:4.2 | 6fgdA-3q98A:22.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3r2i | EXOTOXIN 5 (Staphylococcusaureus) |
PF02876(Stap_Strp_tox_C)PF09199(SSL_OB) | 3 | LEU A 176LEU A 206ARG A 173 | None | 0.64A | 6fgdA-3r2iA:undetectable | 6fgdA-3r2iA:19.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3r2t | PUTATIVEUNCHARACTERIZEDPROTEIN (Staphylococcusaureus) |
PF02876(Stap_Strp_tox_C)PF09199(SSL_OB) | 3 | LEU A 176LEU A 206ARG A 173 | None | 0.62A | 6fgdA-3r2tA:undetectable | 6fgdA-3r2tA:20.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3rim | TRANSKETOLASE (Mycobacteriumtuberculosis) |
PF00456(Transketolase_N)PF02779(Transket_pyr)PF02780(Transketolase_C) | 3 | LEU A 395LEU A 537ARG A 458 | None | 0.67A | 6fgdA-3rimA:2.3 | 6fgdA-3rimA:22.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3smt | HISTONE-LYSINEN-METHYLTRANSFERASESETD3 (Homo sapiens) |
PF00856(SET)PF09273(Rubis-subs-bind) | 3 | LEU A 160LEU A 178ARG A 253 | NoneNoneSAM A1000 (-2.7A) | 0.68A | 6fgdA-3smtA:undetectable | 6fgdA-3smtA:22.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3u4y | UNCHARACTERIZEDPROTEIN (Desulfotomaculumacetoxidans) |
PF10282(Lactonase) | 3 | LEU A 141LEU A 139ARG A 152 | None | 0.65A | 6fgdA-3u4yA:undetectable | 6fgdA-3u4yA:21.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ury | EXOTOXIN (Staphylococcusaureus) |
PF02876(Stap_Strp_tox_C)PF09199(SSL_OB) | 3 | LEU A 253LEU A 282ARG A 250 | None | 0.67A | 6fgdA-3uryA:undetectable | 6fgdA-3uryA:18.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3v7n | THREONINE SYNTHASE (Burkholderiathailandensis) |
PF00291(PALP)PF14821(Thr_synth_N) | 3 | LEU A 104LEU A 114ARG A 91 | None | 0.66A | 6fgdA-3v7nA:undetectable | 6fgdA-3v7nA:21.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4b9d | SERINE/THREONINE-PROTEIN KINASE NEK1 (Homo sapiens) |
PF00069(Pkinase) | 3 | LEU A 88LEU A 136ARG A 91 | None | 0.65A | 6fgdA-4b9dA:undetectable | 6fgdA-4b9dA:21.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4da5 | CHOLINE KINASE ALPHA (Homo sapiens) |
PF01633(Choline_kinase) | 3 | LEU A 414LEU A 292ARG A 411 | None | 0.60A | 6fgdA-4da5A:undetectable | 6fgdA-4da5A:20.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4g34 | EUKARYOTICTRANSLATIONINITIATION FACTOR2-ALPHA KINASE 3 (Homo sapiens) |
PF00069(Pkinase) | 3 | LEU A1017LEU A 914ARG A 910 | None | 0.63A | 6fgdA-4g34A:undetectable | 6fgdA-4g34A:20.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4iwn | TRNA(CMO5U34)-METHYLTRANSFERASE (Escherichiacoli) |
PF13649(Methyltransf_25) | 3 | LEU A 146LEU A 138ARG A 119 | NoneNoneGEK A 301 ( 3.6A) | 0.68A | 6fgdA-4iwnA:2.4 | 6fgdA-4iwnA:20.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4m9x | CELL DEATH PROTEIN 4 (Caenorhabditiselegans) |
PF00619(CARD)PF00931(NB-ARC) | 3 | LEU A 239LEU A 211ARG A 242 | None | 0.61A | 6fgdA-4m9xA:2.0 | 6fgdA-4m9xA:21.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4mgg | MUCONATE LACTONIZINGENZYME (Labrenziaaggregata) |
PF02746(MR_MLE_N)PF13378(MR_MLE_C) | 3 | LEU A 264LEU A 307ARG A 279 | None | 0.55A | 6fgdA-4mggA:undetectable | 6fgdA-4mggA:22.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4nnb | OBCA, OXALATEBIOSYNTHETICCOMPONENT A (Burkholderiaglumae) |
PF05853(BKACE) | 3 | LEU A 423LEU A 408ARG A 419 | None | 0.58A | 6fgdA-4nnbA:undetectable | 6fgdA-4nnbA:21.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4nv7 | ARYLAMINEN-ACETYLTRANSFERASE (Mesorhizobiumjaponicum) |
PF00797(Acetyltransf_2) | 3 | LEU A 87LEU A 9ARG A 22 | None | 0.66A | 6fgdA-4nv7A:undetectable | 6fgdA-4nv7A:22.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ohj | TOXIC SHOCK SYNDROMETOXIN-1 (Staphylococcusaureus) |
PF02876(Stap_Strp_tox_C) | 3 | LEU A 177LEU A 208ARG A 174 | None | 0.66A | 6fgdA-4ohjA:undetectable | 6fgdA-4ohjA:20.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4q2b | ENDO-1,4-BETA-D-GLUCANASE (Pseudomonasputida) |
PF01270(Glyco_hydro_8) | 3 | LEU A 156LEU A 164ARG A 154 | None | 0.63A | 6fgdA-4q2bA:undetectable | 6fgdA-4q2bA:21.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4qjy | GH127BETA-L-ARABINOFURANOSIDASE (Geobacillusstearothermophilus) |
PF07944(Glyco_hydro_127) | 3 | LEU A 546LEU A 569ARG A 530 | None | 0.63A | 6fgdA-4qjyA:undetectable | 6fgdA-4qjyA:20.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4qn9 | N-ACYL-PHOSPHATIDYLETHANOLAMINE-HYDROLYZING PHOSPHOLIPASE D (Homo sapiens) |
PF12706(Lactamase_B_2) | 3 | LEU A 215LEU A 191ARG A 257 | None | 0.54A | 6fgdA-4qn9A:undetectable | 6fgdA-4qn9A:22.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4rco | PUTATIVEUNCHARACTERIZEDPROTEIN (Staphylococcusaureus) |
PF02876(Stap_Strp_tox_C)PF09199(SSL_OB) | 3 | LEU A 253LEU A 282ARG A 250 | None | 0.68A | 6fgdA-4rcoA:undetectable | 6fgdA-4rcoA:22.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4rgt | PUTATIVEUNCHARACTERIZEDPROTEIN (Staphylococcusaureus) |
PF02876(Stap_Strp_tox_C)PF09199(SSL_OB) | 3 | LEU A 172LEU A 203ARG A 169 | None | 0.60A | 6fgdA-4rgtA:undetectable | 6fgdA-4rgtA:19.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4tpt | LIM DOMAIN KINASE 2 (Homo sapiens) |
PF07714(Pkinase_Tyr) | 3 | LEU A 403LEU A 472ARG A 364 | 35H A 701 ( 4.2A)35H A 701 (-3.7A)None | 0.62A | 6fgdA-4tptA:undetectable | 6fgdA-4tptA:20.57 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4u90 | GEPHYRIN (Rattusnorvegicus) |
PF00994(MoCF_biosynth)PF03453(MoeA_N)PF03454(MoeA_C) | 3 | LEU A 323LEU A 605ARG A 670 | None | 0.39A | 6fgdA-4u90A:50.7 | 6fgdA-4u90A:100.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4y93 | NON-SPECIFICPROTEIN-TYROSINEKINASE,NON-SPECIFICPROTEIN-TYROSINEKINASE (Bos taurus) |
PF00169(PH)PF00779(BTK)PF07714(Pkinase_Tyr) | 3 | LEU A 29LEU A 31ARG A 49 | None | 0.57A | 6fgdA-4y93A:undetectable | 6fgdA-4y93A:21.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4yla | AROMATICPRENYLTRANSFERASE (Marinactinosporathermotolerans) |
PF11991(Trp_DMAT) | 3 | LEU A 143LEU A 224ARG A 139 | None | 0.59A | 6fgdA-4ylaA:undetectable | 6fgdA-4ylaA:23.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4zch | TUMOR NECROSISFACTOR LIGANDSUPERFAMILY MEMBER13,TUMOR NECROSISFACTOR LIGANDSUPERFAMILY MEMBER13B,TUMOR NECROSISFACTOR LIGANDSUPERFAMILY MEMBER13B (Homo sapiens) |
PF00229(TNF) | 3 | LEU A 117LEU A 111ARG A 76 | None | 0.63A | 6fgdA-4zchA:undetectable | 6fgdA-4zchA:22.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4zch | TUMOR NECROSISFACTOR LIGANDSUPERFAMILY MEMBER13,TUMOR NECROSISFACTOR LIGANDSUPERFAMILY MEMBER13B,TUMOR NECROSISFACTOR LIGANDSUPERFAMILY MEMBER13B (Homo sapiens) |
PF00229(TNF) | 3 | LEU A 267LEU A 261ARG A 222 | None | 0.64A | 6fgdA-4zchA:undetectable | 6fgdA-4zchA:22.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4zi9 | MCG133388, ISOFORMCRA_T (Mus musculus) |
PF00028(Cadherin)PF08266(Cadherin_2) | 3 | LEU A 46LEU A 67ARG A 43 | None | 0.68A | 6fgdA-4zi9A:undetectable | 6fgdA-4zi9A:23.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5awm | STRESS-ACTIVATEDPROTEIN KINASE JNK (Drosophilamelanogaster) |
PF00069(Pkinase) | 3 | LEU A 129LEU A 121ARG A 125 | None | 0.46A | 6fgdA-5awmA:undetectable | 6fgdA-5awmA:23.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5d3i | STAPHYLOCOCCALSUPERANTIGEN-LIKEPROTEIN 3 (Staphylococcusaureus) |
PF02876(Stap_Strp_tox_C)PF09199(SSL_OB) | 3 | LEU B 271LEU B 300ARG B 268 | None | 0.66A | 6fgdA-5d3iB:undetectable | 6fgdA-5d3iB:19.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5e5u | CONTACTIN-6 (Mus musculus) |
PF13927(Ig_3) | 3 | LEU B 181LEU B 164ARG B 172 | NoneACY B 401 ( 4.8A)ACY B 401 ( 2.6A) | 0.65A | 6fgdA-5e5uB:undetectable | 6fgdA-5e5uB:20.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5fka | STAPHYLOCOCCALENTEROTOXIN E (Staphylococcusaureus) |
PF01123(Stap_Strp_toxin)PF02876(Stap_Strp_tox_C) | 3 | LEU C 163LEU C 198ARG C 160 | None | 0.59A | 6fgdA-5fkaC:undetectable | 6fgdA-5fkaC:21.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5fqe | BETA-N-ACETYLGALACTOSAMINIDASE (Clostridiumperfringens) |
PF13320(DUF4091) | 3 | LEU A 506LEU A 484ARG A 502 | None | 0.64A | 6fgdA-5fqeA:undetectable | 6fgdA-5fqeA:20.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ftg | CHOLINE KINASE ALPHA (Homo sapiens) |
PF01633(Choline_kinase) | 3 | LEU A 414LEU A 292ARG A 411 | None | 0.67A | 6fgdA-5ftgA:undetectable | 6fgdA-5ftgA:21.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5gw5 | T-COMPLEX PROTEIN 1SUBUNIT DELTA (Saccharomycescerevisiae) |
PF00118(Cpn60_TCP1) | 3 | LEU d 150LEU d 179ARG d 147 | None | 0.68A | 6fgdA-5gw5d:2.1 | 6fgdA-5gw5d:23.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5i4d | SUPERANTIGEN-LIKEPROTEIN (Staphylococcusaureus) |
PF02876(Stap_Strp_tox_C)PF09199(SSL_OB) | 3 | LEU A 301LEU A 330ARG A 298 | None | 0.64A | 6fgdA-5i4dA:undetectable | 6fgdA-5i4dA:21.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ioj | HALOALKYLPHOSPHORUSHYDROLASE (Sphingobium sp.TCM1) |
no annotation | 3 | LEU A 487LEU A 577ARG A 503 | None | 0.64A | 6fgdA-5iojA:undetectable | 6fgdA-5iojA:22.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5it3 | LYSINE-SPECIFICHISTONE DEMETHYLASE1A (Homo sapiens) |
PF04433(SWIRM) | 3 | LEU A 261LEU A 183ARG A 214 | None | 0.56A | 6fgdA-5it3A:undetectable | 6fgdA-5it3A:12.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5kel | EBOLA SURFACEGLYCOPROTEIN, GP1 (Zaireebolavirus) |
PF01611(Filo_glycop) | 3 | LEU A 184LEU A 186ARG A 64 | None | 0.68A | 6fgdA-5kelA:undetectable | 6fgdA-5kelA:24.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ken | EBOLA SURFACEGLYCOPROTEIN, GP1 (Zaireebolavirus) |
PF01611(Filo_glycop) | 3 | LEU A 184LEU A 186ARG A 64 | None | 0.67A | 6fgdA-5kenA:undetectable | 6fgdA-5kenA:21.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5l3d | LYSINE-SPECIFICHISTONE DEMETHYLASE1A (Homo sapiens) |
PF01593(Amino_oxidase)PF04433(SWIRM) | 3 | LEU A 261LEU A 183ARG A 214 | None | 0.48A | 6fgdA-5l3dA:undetectable | 6fgdA-5l3dA:19.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5lf9 | NUCLEOSIDEDIPHOSPHATE-LINKEDMOIETY X MOTIF 22 (Homo sapiens) |
no annotation | 3 | LEU A 102LEU A 34ARG A 31 | None | 0.48A | 6fgdA-5lf9A:undetectable | 6fgdA-5lf9A:23.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5mwr | TETR FAMILYTRANSCRIPTIONALREGULATOR (Sulfolobusacidocaldarius) |
no annotation | 3 | LEU A 193LEU A 137ARG A 86 | NonePTR A 133 ( 3.6A)PTR A 133 ( 4.3A) | 0.65A | 6fgdA-5mwrA:undetectable | 6fgdA-5mwrA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5oet | GLUTATHIONESYNTHETASE-LIKEEFFECTOR 30(GPA-GSS30-APO) (Globoderapallida) |
no annotation | 3 | LEU B 248LEU B 302ARG B 280 | None | 0.68A | 6fgdA-5oetB:undetectable | 6fgdA-5oetB:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5tws | HUMAN DNA POLYMERASEMU (Homo sapiens) |
PF10391(DNA_pol_lambd_f)PF14716(HHH_8)PF14791(DNA_pol_B_thumb)PF14792(DNA_pol_B_palm) | 3 | LEU A 444LEU A 432ARG A 492 | None | 0.49A | 6fgdA-5twsA:undetectable | 6fgdA-5twsA:22.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5wyr | TRNA(GUANINE-N(1)-)-METHYLTRANSFERASE (Pseudomonasaeruginosa) |
no annotation | 3 | LEU A 229LEU A 180ARG A 232 | None | 0.67A | 6fgdA-5wyrA:2.5 | 6fgdA-5wyrA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xly | CYCLIC DIGUANOSINEMONOPHOSPHATE-BINDING PROTEIN PA4608 (Pseudomonasaeruginosa) |
PF07238(PilZ) | 3 | LEU B 38LEU B 112ARG B 99 | None | 0.67A | 6fgdA-5xlyB:undetectable | 6fgdA-5xlyB:14.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5yti | FLAGELLAR HOOKASSOCIATED PROTEINTYPE 3 FLGL (Legionellapneumophila) |
no annotation | 3 | LEU A 352LEU A 73ARG A 348 | None | 0.64A | 6fgdA-5ytiA:undetectable | 6fgdA-5ytiA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6bgi | ANOCTAMIN-1 (Mus musculus) |
no annotation | 3 | LEU A 861LEU A 857ARG A 860 | None | 0.64A | 6fgdA-6bgiA:undetectable | 6fgdA-6bgiA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6bhu | MULTIDRUGRESISTANCE-ASSOCIATED PROTEIN 1 (Bos taurus) |
no annotation | 3 | LEU A 824LEU A 673ARG A 822 | None | 0.67A | 6fgdA-6bhuA:undetectable | 6fgdA-6bhuA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6en4 | SPLICING FACTOR 3BSUBUNIT 3 (Homo sapiens) |
no annotation | 3 | LEU A 438LEU A 404ARG A 436 | None | 0.63A | 6fgdA-6en4A:undetectable | 6fgdA-6en4A:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6etz | BETA-GALACTOSIDASE (Arthrobactersp. 32cB) |
no annotation | 3 | LEU A 963LEU A 954ARG A 947 | None | 0.59A | 6fgdA-6etzA:undetectable | 6fgdA-6etzA:undetectable |