SIMILAR PATTERNS OF AMINO ACIDS FOR 6FGC_A_D95A816

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ce7 PROTEIN
(RIBOSOME-INACTIVATI
NG PROTEIN TYPE II)

(Viscum album) 		PF00161
(RIP) 		5 PHE A  20
ILE A  21
LEU A  24
LEU A   6
ILE A  65
 None
 1.45A 6fgcA-1ce7A:
0.6		 6fgcA-1ce7A:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dq3 ENDONUCLEASE

(Pyrococcus
furiosus) 		PF09061
(Stirrup)
PF09062
(Endonuc_subdom)
PF14528
(LAGLIDADG_3)
PF14890
(Intein_splicing) 		5 PHE A 242
ILE A 243
LEU A 246
LEU A 219
PRO A 228
 None
 1.40A 6fgcA-1dq3A:
undetectable		 6fgcA-1dq3A:
10.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1foe T-LYMPHOMA INVASION
AND METASTASIS
INDUCING PROTEIN 1

(Mus musculus) 		PF00169
(PH)
PF00621
(RhoGEF) 		5 ASP A1261
ILE A1249
LEU A1248
LEU A1267
ILE A1393
 None
 1.35A 6fgcA-1foeA:
undetectable		 6fgcA-1foeA:
12.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h3j PEROXIDASE

(Coprinopsis
cinerea) 		PF00141
(peroxidase)
PF11895
(Peroxidase_ext) 		5 PHE A 236
LEU A 339
LEU A 336
PRO A 309
ILE A 308
 None
 1.39A 6fgcA-1h3jA:
undetectable		 6fgcA-1h3jA:
12.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kp2 ARGININOSUCCINATE
SYNTHETASE

(Escherichia
coli) 		PF00764
(Arginosuc_synth) 		5 PHE A 161
ILE A 162
LEU A 165
LEU A   7
ILE A  15
 None
 1.44A 6fgcA-1kp2A:
undetectable		 6fgcA-1kp2A:
12.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lxy ARGININE DEIMINASE

(Mycoplasma
arginini) 		PF02274
(Amidinotransf) 		5 PHE A  45
ILE A  48
LEU A  49
LEU A  44
PRO A 154
 CIR  A 500 ( 4.9A)
None
None
CIR  A 500 (-3.5A)
None
 1.25A 6fgcA-1lxyA:
0.0		 6fgcA-1lxyA:
11.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pox PYRUVATE OXIDASE

(Lactobacillus
plantarum) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		5 ASP A 566
PHE A 570
ILE A 567
LEU A 557
PRO A 551
 None
 1.33A 6fgcA-1poxA:
0.0		 6fgcA-1poxA:
9.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v3t LEUKOTRIENE B4
12-HYDROXYDEHYDROGEN
ASE/PROSTAGLANDIN
15-KETO REDUCTASE

(Cavia porcellus) 		PF00107
(ADH_zinc_N)
PF16884
(ADH_N_2) 		5 PHE A 313
ILE A 314
LEU A 317
ARG A  51
MET A  64
 None
 1.46A 6fgcA-1v3tA:
0.9		 6fgcA-1v3tA:
13.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vol PROTEIN
(TRANSCRIPTION
FACTOR IIB (TFIIB))

(Homo sapiens) 		PF00382
(TFIIB) 		5 ASP A 243
LEU A 299
LEU A 291
ARG A 295
PRO A 294
 None
 1.47A 6fgcA-1volA:
undetectable		 6fgcA-1volA:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w85 PYRUVATE
DEHYDROGENASE E1
COMPONENT, BETA
SUBUNIT

(Geobacillus
stearothermophilus) 		PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		5 ASP B 130
PHE B  83
LEU B 170
LEU B 135
MET B  90
 None
 1.44A 6fgcA-1w85B:
3.6		 6fgcA-1w85B:
17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bx7 DIHYDROOROTATE
DEHYDROGENASE

(Lactococcus
lactis) 		PF01180
(DHO_dh) 		5 PHE A  15
ILE A 270
LEU A 268
ILE A 292
MET A 293
 None
 1.36A 6fgcA-2bx7A:
undetectable		 6fgcA-2bx7A:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ch1 3-HYDROXYKYNURENINE
TRANSAMINASE

(Anopheles
gambiae) 		PF00266
(Aminotran_5) 		5 MET A 191
PHE A  64
ILE A  63
LEU A  60
MET A  85
 None
 1.46A 6fgcA-2ch1A:
2.3		 6fgcA-2ch1A:
12.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2drw D-AMINO ACID AMIDASE

(Ochrobactrum
anthropi) 		PF00144
(Beta-lactamase) 		5 MET A 183
PHE A 255
LEU A 259
ILE A  58
MET A 245
 None
 1.31A 6fgcA-2drwA:
undetectable		 6fgcA-2drwA:
14.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fgt TWO-COMPONENT SYSTEM
YYCF/YYCG REGULATORY
PROTEIN YYCH

(Bacillus
subtilis) 		PF07435
(YycH) 		5 ASP A 137
PHE A 139
ILE A 136
LEU A 173
LEU A 142
 None
 1.47A 6fgcA-2fgtA:
undetectable		 6fgcA-2fgtA:
10.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gtr CHROMODOMAIN Y-LIKE
PROTEIN

(Homo sapiens) 		PF00378
(ECH_1) 		5 PHE A  71
ILE A  72
LEU A  75
ILE A  90
MET A  35
 None
 1.48A 6fgcA-2gtrA:
2.0		 6fgcA-2gtrA:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h34 SERINE/THREONINE-PRO
TEIN KINASE PKNE

(Mycobacterium
tuberculosis) 		PF00069
(Pkinase) 		5 ASP A 246
PHE A 245
ILE A 249
LEU A 205
PRO A 113
 None
 1.21A 6fgcA-2h34A:
undetectable		 6fgcA-2h34A:
14.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2px9 SUMO-ACTIVATING
ENZYME SUBUNIT 2

(Homo sapiens) 		PF10585
(UBA_e1_thiolCys) 		5 ILE A 175
LEU A 258
ARG A 176
PRO A 208
ILE A 238
 None
 1.50A 6fgcA-2px9A:
undetectable		 6fgcA-2px9A:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rfl PUTATIVE
PHOSPHOHISTIDINE
PHOSPHATASE SIXA

(Agrobacterium
fabrum) 		PF00300
(His_Phos_1) 		5 PHE A  75
ARG A  52
PRO A  53
ILE A  56
MET A 109
 None
 1.41A 6fgcA-2rflA:
2.2		 6fgcA-2rflA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vd2 ATP
PHOSPHORIBOSYLTRANSF
ERASE

(Bacillus
subtilis) 		PF01634
(HisG) 		5 MET A   9
ILE A  51
LEU A  22
ILE A 196
MET A 199
 None
 1.33A 6fgcA-2vd2A:
undetectable		 6fgcA-2vd2A:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ve3 PUTATIVE CYTOCHROME
P450 120

(Synechocystis
sp. PCC 6803) 		PF00067
(p450) 		5 PHE A 174
ILE A 178
LEU A 170
ILE A 248
MET A 160
 None
 1.45A 6fgcA-2ve3A:
undetectable		 6fgcA-2ve3A:
10.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x3k ACSD

(Dickeya
chrysanthemi) 		PF04183
(IucA_IucC)
PF06276
(FhuF) 		5 MET A 383
LEU A 160
LEU A 166
PRO A 192
ILE A 280
 None
 1.24A 6fgcA-2x3kA:
undetectable		 6fgcA-2x3kA:
7.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xpp IWS1

(Encephalitozoon
cuniculi) 		PF08711
(Med26) 		5 ASP A 117
LEU A 123
LEU A 101
ILE A 149
MET A 147
 None
 1.39A 6fgcA-2xppA:
undetectable		 6fgcA-2xppA:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y6e UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 4

(Homo sapiens) 		PF00443
(UCH) 		5 ASP A 367
ILE A 297
LEU A 301
LEU A 304
ILE A 359
 None
 1.30A 6fgcA-2y6eA:
undetectable		 6fgcA-2y6eA:
12.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cg3 UPF0100 PROTEIN
PH0151

(Pyrococcus
horikoshii) 		PF13531
(SBP_bac_11) 		5 ILE A 296
LEU A 299
LEU A 286
ILE A 100
MET A  99
 None
 1.44A 6fgcA-3cg3A:
undetectable		 6fgcA-3cg3A:
11.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d36 SPORULATION KINASE B
SPORULATION KINASE
INHIBITOR SDA

(Geobacillus
stearothermophilus;
Geobacillus
stearothermophilus) 		PF00512
(HisKA)
PF02518
(HATPase_c)
PF08970
(Sda) 		5 PHE C  25
LEU C  21
LEU C  28
ILE A 245
MET C   1
 None
 1.24A 6fgcA-3d36C:
undetectable		 6fgcA-3d36C:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ddc RAS ASSOCIATION
DOMAIN-CONTAINING
FAMILY PROTEIN 5

(Mus musculus) 		PF00788
(RA) 		5 ILE B 332
LEU B 330
LEU B 300
ILE B 287
MET B 285
 None
 1.42A 6fgcA-3ddcB:
undetectable		 6fgcA-3ddcB:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dpu RAB FAMILY PROTEIN

(Chlorobaculum
tepidum) 		PF08477
(Roc)
PF16095
(COR) 		5 ILE A 709
LEU A 780
PRO A 811
ILE A 815
MET A 814
 None
 1.35A 6fgcA-3dpuA:
1.9		 6fgcA-3dpuA:
9.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gnq GLYCERALDEHYDE-3-PHO
SPHATE
DEHYDROGENASE, TYPE
I

(Burkholderia
pseudomallei) 		PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C) 		5 LEU A 222
LEU A 162
PRO A 165
ILE A 262
MET A 263
 None
 1.11A 6fgcA-3gnqA:
undetectable		 6fgcA-3gnqA:
13.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gnq GLYCERALDEHYDE-3-PHO
SPHATE
DEHYDROGENASE, TYPE
I

(Burkholderia
pseudomallei) 		PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C) 		5 LEU A 225
LEU A 162
PRO A 165
ILE A 262
MET A 263
 None
 1.27A 6fgcA-3gnqA:
undetectable		 6fgcA-3gnqA:
13.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hmj FATTY ACID SYNTHASE
SUBUNIT ALPHA

(Saccharomyces
cerevisiae) 		PF00109
(ketoacyl-synt)
PF01648
(ACPS)
PF02801
(Ketoacyl-synt_C) 		5 ILE A1103
LEU A1580
ILE A1097
MET A1057
MET A1053
 None
 0.95A 6fgcA-3hmjA:
1.9		 6fgcA-3hmjA:
3.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3icf SERINE/THREONINE-PRO
TEIN PHOSPHATASE T

(Saccharomyces
cerevisiae) 		PF00149
(Metallophos)
PF08321
(PPP5) 		5 MET A 231
PHE A 373
ILE A 376
LEU A 370
ILE A 430
 None
 1.12A 6fgcA-3icfA:
undetectable		 6fgcA-3icfA:
14.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k30 HISTAMINE
DEHYDROGENASE

(Pimelobacter
simplex) 		PF00724
(Oxidored_FMN)
PF07992
(Pyr_redox_2) 		5 ASP A 258
PHE A  23
ILE A  20
LEU A 104
ILE A 166
 None
 1.22A 6fgcA-3k30A:
undetectable		 6fgcA-3k30A:
7.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l9x GLUTATHIONE-REGULATE
D POTASSIUM-EFFLUX
SYSTEM PROTEIN KEFC,
LINKER, ANCILLARY
PROTEIN KEFF

(Escherichia
coli) 		PF02254
(TrkA_N)
PF02525
(Flavodoxin_2) 		5 ILE A1032
LEU A1003
LEU A1074
ARG A1033
ILE A1044
 None
 1.50A 6fgcA-3l9xA:
3.2		 6fgcA-3l9xA:
10.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nd0 SLL0855 PROTEIN

(Synechocystis
sp. PCC 6803) 		PF00654
(Voltage_CLC) 		5 MET A 260
PHE A 257
LEU A 253
LEU A 389
ILE A 358
 None
 1.47A 6fgcA-3nd0A:
undetectable		 6fgcA-3nd0A:
11.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p8c NCK-ASSOCIATED
PROTEIN 1

(Homo sapiens) 		PF09735
(Nckap1) 		5 ILE B1051
LEU B1055
LEU B 999
ILE B 910
MET B 907
 None
 1.19A 6fgcA-3p8cB:
undetectable		 6fgcA-3p8cB:
6.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pxn KINESIN-LIKE PROTEIN
NOD

(Drosophila
melanogaster) 		PF00225
(Kinesin) 		5 ILE A 256
LEU A 253
LEU A 294
ILE A 224
MET A  97
 None
 1.48A 6fgcA-3pxnA:
undetectable		 6fgcA-3pxnA:
14.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qdk RIBULOKINASE

(Bacillus
halodurans) 		PF00370
(FGGY_N)
PF02782
(FGGY_C) 		5 PHE A 460
ILE A 459
LEU A 456
LEU A 443
ILE A 429
 None
 1.08A 6fgcA-3qdkA:
undetectable		 6fgcA-3qdkA:
9.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s46 ALANINE RACEMASE

(Streptococcus
pneumoniae) 		PF00842
(Ala_racemase_C)
PF01168
(Ala_racemase_N) 		5 PHE A  62
LEU A  78
ILE A  22
MET A 219
MET A 223
 None
 1.31A 6fgcA-3s46A:
undetectable		 6fgcA-3s46A:
13.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sd7 PUTATIVE PHOSPHATASE

(Clostridioides
difficile) 		PF13419
(HAD_2) 		5 ASP A 126
PHE A 129
ILE A 132
ILE A  87
MET A  91
 PGE  A 219 (-3.8A)
None
None
None
None
 1.42A 6fgcA-3sd7A:
2.0		 6fgcA-3sd7A:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tov GLYCOSYL TRANSFERASE
FAMILY 9

(Veillonella
parvula) 		PF01075
(Glyco_transf_9) 		5 PHE A  25
ILE A 141
LEU A 144
ILE A  56
MET A  50
 None
 1.34A 6fgcA-3tovA:
1.6		 6fgcA-3tovA:
12.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vkg DYNEIN HEAVY CHAIN,
CYTOPLASMIC

(Dictyostelium
discoideum) 		PF03028
(Dynein_heavy)
PF07728
(AAA_5)
PF08393
(DHC_N2)
PF12774
(AAA_6)
PF12775
(AAA_7)
PF12777
(MT)
PF12780
(AAA_8)
PF12781
(AAA_9) 		5 MET A4260
ILE A4270
LEU A4273
ARG A4269
PRO A4384
 None
 1.13A 6fgcA-3vkgA:
undetectable		 6fgcA-3vkgA:
2.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wa1 BINB PROTEIN

(Lysinibacillus
sphaericus) 		PF05431
(Toxin_10) 		5 ASP A 106
PHE A 105
LEU A  84
LEU A 158
ARG A  82
 None
 1.47A 6fgcA-3wa1A:
undetectable		 6fgcA-3wa1A:
14.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cem REGULATOR OF
NONSENSE TRANSCRIPTS
2

(Homo sapiens) 		PF02854
(MIF4G) 		5 PHE A 229
ILE A 202
LEU A 198
LEU A 228
ILE A 181
 None
 1.25A 6fgcA-4cemA:
undetectable		 6fgcA-4cemA:
13.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gq2 NUCLEOPORIN NUP120

(Schizosaccharomyces
pombe) 		PF11715
(Nup160) 		5 MET M 251
ILE M 297
LEU M 314
LEU M 261
ILE M 178
 None
 1.38A 6fgcA-4gq2M:
undetectable		 6fgcA-4gq2M:
5.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hzs ACTIVATED CDC42
KINASE 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14604
(SH3_9) 		5 PHE A 271
ILE A 268
LEU A 243
LEU A 192
MET A 203
 None
 1.50A 6fgcA-4hzsA:
undetectable		 6fgcA-4hzsA:
13.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iug BETA-GALACTOSIDASE A

(Aspergillus
oryzae) 		PF01301
(Glyco_hydro_35)
PF10435
(BetaGal_dom2)
PF13363
(BetaGal_dom3)
PF13364
(BetaGal_dom4_5) 		5 MET A  61
PHE A 339
LEU A 296
LEU A 332
ILE A 382
 None
 1.47A 6fgcA-4iugA:
undetectable		 6fgcA-4iugA:
6.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ixu ARGINASE-2,
MITOCHONDRIAL

(Homo sapiens) 		PF00491
(Arginase) 		5 ASP A 253
PHE A 255
ILE A 252
LEU A 314
MET A 219
 MN  A 402 ( 2.0A)
None
None
None
None
 1.44A 6fgcA-4ixuA:
undetectable		 6fgcA-4ixuA:
15.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lls GERANYLTRANSTRANSFER
ASE

(Roseobacter
denitrificans) 		PF00348
(polyprenyl_synt) 		5 ASP A 217
ILE A 218
LEU A 259
ARG A 287
ILE A 183
 None
None
None
IPE  A 301 ( 4.3A)
None
 1.40A 6fgcA-4llsA:
undetectable		 6fgcA-4llsA:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lxr PROTEIN TOLL

(Drosophila
melanogaster) 		PF00560
(LRR_1)
PF01462
(LRRNT)
PF13306
(LRR_5)
PF13855
(LRR_8) 		5 PHE A 155
ILE A 131
LEU A 130
LEU A 179
ILE A 165
 None
 1.47A 6fgcA-4lxrA:
undetectable		 6fgcA-4lxrA:
6.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mfv BETA-CATENIN-LIKE
PROTEIN 1

(Homo sapiens) 		PF08216
(CTNNBL) 		5 MET A 387
PHE A 383
ILE A 382
LEU A 379
ILE A 503
 None
 1.00A 6fgcA-4mfvA:
undetectable		 6fgcA-4mfvA:
9.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p5e 2'-DEOXYNUCLEOSIDE
5'-PHOSPHATE
N-HYDROLASE 1

(Homo sapiens) 		PF05014
(Nuc_deoxyrib_tr) 		5 ASP A 155
PHE A 158
LEU A 163
LEU A 116
ILE A  42
 None
 1.22A 6fgcA-4p5eA:
2.7		 6fgcA-4p5eA:
25.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p6v NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT C
NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT D

(Vibrio
cholerae;
Vibrio cholerae) 		PF04205
(FMN_bind)
PF02508
(Rnf-Nqr) 		5 PHE D  58
ILE D  62
LEU D  61
LEU D  82
ILE C  24
 None
 1.31A 6fgcA-4p6vD:
undetectable		 6fgcA-4p6vD:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r16 418AA LONG
HYPOTHETICAL
UDP-N-ACETYL-D-MANNO
SAMINURONIC ACID
DEHYDROGENASE

(Pyrococcus
horikoshii) 		PF00984
(UDPG_MGDP_dh)
PF03720
(UDPG_MGDP_dh_C)
PF03721
(UDPG_MGDP_dh_N) 		5 ASP A 373
PHE A 377
ILE A 370
LEU A 314
PRO A 349
 None
 1.40A 6fgcA-4r16A:
undetectable		 6fgcA-4r16A:
13.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4u90 GEPHYRIN

(Rattus
norvegicus) 		PF00994
(MoCF_biosynth)
PF03453
(MoeA_N)
PF03454
(MoeA_C) 		10 ASP A 327
PHE A 330
ILE A 331
LEU A 334
LEU A 637
ARG A 653
PRO A 654
ILE A 656
MET A 711
MET A 731
 None
 0.39A 6fgcA-4u90A:
51.0		 6fgcA-4u90A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4u90 GEPHYRIN

(Rattus
norvegicus) 		PF00994
(MoCF_biosynth)
PF03453
(MoeA_N)
PF03454
(MoeA_C) 		10 MET A 326
ASP A 327
PHE A 330
ILE A 331
LEU A 334
LEU A 637
PRO A 654
ILE A 656
MET A 711
MET A 731
 None
 0.48A 6fgcA-4u90A:
51.0		 6fgcA-4u90A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4u90 GEPHYRIN

(Rattus
norvegicus) 		PF00994
(MoCF_biosynth)
PF03453
(MoeA_N)
PF03454
(MoeA_C) 		5 PHE A 330
ILE A 331
LEU A 637
PRO A 641
MET A 731
 None
 1.39A 6fgcA-4u90A:
51.0		 6fgcA-4u90A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xxh HTH-TYPE
TRANSCRIPTIONAL
REGULATOR TRER

(Escherichia
coli) 		PF13377
(Peripla_BP_3) 		5 PHE A  88
ILE A 296
LEU A  85
ILE A  96
MET A  97
 None
 1.33A 6fgcA-4xxhA:
6.4		 6fgcA-4xxhA:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ykn PHOSPHATIDYLINOSITOL
3-KINASE REGULATORY
SUBUNIT
ALPHA,PHOSPHATIDYLIN
OSITOL
4,5-BISPHOSPHATE
3-KINASE CATALYTIC
SUBUNIT ALPHA
ISOFORM FUSION
PROTEIN

(Homo sapiens) 		PF00017
(SH2)
PF00454
(PI3_PI4_kinase)
PF00613
(PI3Ka)
PF00792
(PI3K_C2)
PF00794
(PI3K_rbd)
PF02192
(PI3K_p85B)
PF16454
(PI3K_P85_iSH2) 		5 MET A2005
PHE A2002
ILE A2019
LEU A1938
ILE A1819
 None
 1.35A 6fgcA-4yknA:
undetectable		 6fgcA-4yknA:
4.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a8j VWA2

(Sulfolobus
acidocaldarius) 		PF00092
(VWA) 		5 ILE A 133
LEU A 134
LEU A 165
ILE A  58
MET A  52
 None
 1.02A 6fgcA-5a8jA:
4.0		 6fgcA-5a8jA:
13.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d1v GLOBIN

(Chloroflexus
aurantiacus) 		PF01152
(Bac_globin) 		5 MET A  92
LEU A  52
ARG A  18
ILE A  10
MET A 109
 None
 1.22A 6fgcA-5d1vA:
undetectable		 6fgcA-5d1vA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e1v POLYKETIDE SYNTHASE
PKSL

(Bacillus
subtilis) 		no annotation 5 ASP B  41
ILE B 198
LEU B 271
ILE B  92
MET B 116
 None
 1.45A 6fgcA-5e1vB:
undetectable		 6fgcA-5e1vB:
14.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e4v NUCLEOPROTEIN,PHOSPH
OPROTEIN

(Measles
morbillivirus) 		PF00973
(Paramyxo_ncap)
PF13825
(Paramyxo_PNT) 		5 PHE A 112
LEU A  95
LEU A  39
PRO A  19
ILE A  17
 None
 1.05A 6fgcA-5e4vA:
undetectable		 6fgcA-5e4vA:
11.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jh5 LYSINE-SPECIFIC
DEMETHYLASE 2B

(Homo sapiens) 		PF00646
(F-box) 		5 MET A1237
LEU A1270
LEU A1218
ILE A1225
MET A1191
 None
 1.34A 6fgcA-5jh5A:
undetectable		 6fgcA-5jh5A:
16.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kku POLYKETIDE SYNTHASE
TYPE I

(Bacillus
amyloliquefaciens) 		PF14765
(PS-DH) 		5 PHE A 196
LEU A 179
LEU A 197
ARG A 187
MET A 229
 None
 1.41A 6fgcA-5kkuA:
undetectable		 6fgcA-5kkuA:
15.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ojs TRANSCRIPTION-ASSOCI
ATED PROTEIN 1

(Saccharomyces
cerevisiae) 		PF00454
(PI3_PI4_kinase)
PF02259
(FAT) 		5 ASP T2552
PHE T2549
ILE T2548
LEU T2545
MET T2605
 None
 1.32A 6fgcA-5ojsT:
undetectable		 6fgcA-5ojsT:
1.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wvr KLLA0C04147P

(Kluyveromyces
lactis) 		PF01237
(Oxysterol_BP) 		5 ASP A1238
PHE A1240
LEU A 926
LEU A1160
PRO A1162
 None
 1.49A 6fgcA-5wvrA:
undetectable		 6fgcA-5wvrA:
12.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xgj PHOSPHATIDYLINOSITOL
4,5-BISPHOSPHATE
3-KINASE CATALYTIC
SUBUNIT ALPHA
ISOFORM

(Homo sapiens) 		no annotation 5 MET A1005
PHE A1002
ILE A1019
LEU A 938
ILE A 819
 None
 1.32A 6fgcA-5xgjA:
undetectable		 6fgcA-5xgjA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xx9 BACTERIOFERRITIN

(Streptomyces
coelicolor) 		no annotation 5 ASP A   4
ILE A   8
LEU A  11
ARG A  61
ILE A 114
 None
 1.31A 6fgcA-5xx9A:
undetectable		 6fgcA-5xx9A:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yrz HICB

(Streptococcus
pneumoniae) 		no annotation 5 PHE A   9
ILE A  38
LEU A  42
LEU A   8
ILE A  69
 None
SO4  A 201 (-4.0A)
None
None
None
 1.46A 6fgcA-5yrzA:
undetectable		 6fgcA-5yrzA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bk5 UBIQUITIN LIGASE CBL

(Salpingoeca
rosetta) 		no annotation 5 MET A 144
PHE A 141
ILE A  72
LEU A  73
ILE A 111
 None
 1.42A 6fgcA-6bk5A:
undetectable		 6fgcA-6bk5A:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c0b TOXIN B

(Clostridioides
difficile) 		no annotation 5 ASP A1748
PHE A1767
ILE A1750
LEU A1751
LEU A1780
 None
 1.38A 6fgcA-6c0bA:
undetectable		 6fgcA-6c0bA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ez8 HUNTINGTIN

(Homo sapiens) 		no annotation 5 PHE A1584
ILE A1585
LEU A1588
LEU A1571
ILE A1609
 None
 1.48A 6fgcA-6ez8A:
undetectable		 6fgcA-6ez8A:
18.18