SIMILAR PATTERNS OF AMINO ACIDS FOR 6FGC_A_ACTA811_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1et6 SUPERANTIGEN SMEZ-2

(Streptococcus
pyogenes) 		PF01123
(Stap_Strp_toxin)
PF02876
(Stap_Strp_tox_C) 		3 LEU A 141
LEU A 174
ARG A 138
 None
 0.63A 6fgcA-1et6A:
undetectable		 6fgcA-1et6A:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1et9 SUPERANTIGEN SPE-H

(Streptococcus
pyogenes) 		PF01123
(Stap_Strp_toxin)
PF02876
(Stap_Strp_tox_C) 		3 LEU A 138
LEU A 171
ARG A 135
 None
 0.64A 6fgcA-1et9A:
0.0		 6fgcA-1et9A:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jc9 TECHYLECTIN-5A

(Tachypleus
tridentatus) 		PF00147
(Fibrinogen_C) 		3 LEU A 133
LEU A 125
ARG A 129
 None
 0.70A 6fgcA-1jc9A:
0.0		 6fgcA-1jc9A:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kej TERMINAL
DEOXYNUCLEOTIDYLTRAN
SFERASE SHORT
ISOFORM

(Mus musculus) 		PF10391
(DNA_pol_lambd_f)
PF14716
(HHH_8)
PF14791
(DNA_pol_B_thumb)
PF14792
(DNA_pol_B_palm) 		3 LEU A 460
LEU A 448
ARG A 508
 None
 0.52A 6fgcA-1kejA:
1.2		 6fgcA-1kejA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m4v SET3,
SUPERANTIGEN-LIKE
PROTEIN

(Staphylococcus
aureus) 		PF02876
(Stap_Strp_tox_C)
PF09199
(SSL_OB) 		3 LEU A 148
LEU A 178
ARG A 145
 None
 0.62A 6fgcA-1m4vA:
undetectable		 6fgcA-1m4vA:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nf2 PHOSPHATASE

(Thermotoga
maritima) 		PF08282
(Hydrolase_3) 		3 LEU A 198
LEU A  72
ARG A 201
 None
 0.65A 6fgcA-1nf2A:
0.0		 6fgcA-1nf2A:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nfp LUXF GENE PRODUCT

(Photobacterium
leiognathi) 		PF00296
(Bac_luciferase) 		3 LEU A  93
LEU A  68
ARG A 127
 None
 0.51A 6fgcA-1nfpA:
0.0		 6fgcA-1nfpA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u0t INORGANIC
POLYPHOSPHATE/ATP-NA
D KINASE

(Mycobacterium
tuberculosis) 		PF01513
(NAD_kinase) 		3 LEU A 141
LEU A 139
ARG A 274
 None
 0.65A 6fgcA-1u0tA:
3.5		 6fgcA-1u0tA:
23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v1p EXOTOXIN 1

(Staphylococcus
aureus) 		PF02876
(Stap_Strp_tox_C)
PF09199
(SSL_OB) 		3 LEU A 153
LEU A 183
ARG A 150
 None
 0.68A 6fgcA-1v1pA:
undetectable		 6fgcA-1v1pA:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vb3 THREONINE SYNTHASE

(Escherichia
coli) 		PF00291
(PALP)
PF14821
(Thr_synth_N) 		3 LEU A 264
LEU A  47
ARG A 238
 None
 0.64A 6fgcA-1vb3A:
undetectable		 6fgcA-1vb3A:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w6f ARYLAMINE
N-ACETYLTRANSFERASE

(Mycolicibacterium
smegmatis) 		PF00797
(Acetyltransf_2) 		3 LEU A  84
LEU A   5
ARG A  17
 None
 0.64A 6fgcA-1w6fA:
undetectable		 6fgcA-1w6fA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1weh CONSERVED
HYPOTHETICAL PROTEIN
TT1887

(Thermus
thermophilus) 		PF03641
(Lysine_decarbox) 		3 LEU A  97
LEU A  82
ARG A  93
 None
 0.67A 6fgcA-1wehA:
undetectable		 6fgcA-1wehA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xee CHEMOTAXIS-INHIBITIN
G PROTEIN CHIPS

(Staphylococcus
aureus) 		PF11434
(CHIPS) 		3 LEU A  49
LEU A  76
ARG A  46
 None
 0.66A 6fgcA-1xeeA:
undetectable		 6fgcA-1xeeA:
11.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b7u CHARYBDIN

(Drimia maritima) 		PF00161
(RIP) 		3 LEU A 158
LEU A 111
ARG A 154
 None
 0.62A 6fgcA-2b7uA:
undetectable		 6fgcA-2b7uA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dw4 LYSINE-SPECIFIC
HISTONE DEMETHYLASE
1

(Homo sapiens) 		PF01593
(Amino_oxidase)
PF04433
(SWIRM) 		3 LEU A 261
LEU A 183
ARG A 214
 None
 0.56A 6fgcA-2dw4A:
undetectable		 6fgcA-2dw4A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e7a TUMOR NECROSIS
FACTOR

(Homo sapiens) 		PF00229
(TNF) 		3 LEU A 132
LEU A 126
ARG A  82
 None
 0.70A 6fgcA-2e7aA:
undetectable		 6fgcA-2e7aA:
16.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fuq HEPARINASE II
PROTEIN

(Pedobacter
heparinus) 		PF07940
(Hepar_II_III)
PF16332
(DUF4962) 		3 LEU A 697
LEU A 550
ARG A 700
 None
 0.55A 6fgcA-2fuqA:
undetectable		 6fgcA-2fuqA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g9h EXTRACELLULAR
ENTEROTOXIN TYPE I

(Staphylococcus
aureus) 		PF01123
(Stap_Strp_toxin)
PF02876
(Stap_Strp_tox_C) 		3 LEU D 133
LEU D 180
ARG D 130
 None
 0.68A 6fgcA-2g9hD:
undetectable		 6fgcA-2g9hD:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ihm DNA POLYMERASE MU

(Mus musculus) 		PF10391
(DNA_pol_lambd_f)
PF14716
(HHH_8)
PF14791
(DNA_pol_B_thumb)
PF14792
(DNA_pol_B_palm) 		3 LEU A 446
LEU A 434
ARG A 494
 None
 0.65A 6fgcA-2ihmA:
undetectable		 6fgcA-2ihmA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ntt STAPHYLOCOCCAL
ENTEROTOXIN K

(Staphylococcus
aureus) 		PF02876
(Stap_Strp_tox_C) 		3 LEU A 133
LEU A 180
ARG A 130
 None
 0.62A 6fgcA-2nttA:
undetectable		 6fgcA-2nttA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nx9 OXALOACETATE
DECARBOXYLASE 2,
SUBUNIT ALPHA

(Vibrio cholerae) 		PF00682
(HMGL-like)
PF02436
(PYC_OADA) 		3 LEU A 325
LEU A 305
ARG A 294
 None
 0.54A 6fgcA-2nx9A:
undetectable		 6fgcA-2nx9A:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o74 OHCU DECARBOXYLASE

(Danio rerio) 		PF09349
(OHCU_decarbox) 		3 LEU A 125
LEU A 160
ARG A 124
 None
 0.58A 6fgcA-2o74A:
undetectable		 6fgcA-2o74A:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ozu HISTONE
ACETYLTRANSFERASE
MYST3

(Homo sapiens) 		PF01853
(MOZ_SAS) 		3 LEU A 669
LEU A 774
ARG A 672
 None
 0.69A 6fgcA-2ozuA:
undetectable		 6fgcA-2ozuA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q01 URONATE ISOMERASE

(Caulobacter
vibrioides) 		PF02614
(UxaC) 		3 LEU A 438
LEU A 459
ARG A 398
 None
 0.70A 6fgcA-2q01A:
undetectable		 6fgcA-2q01A:
23.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r4i UNCHARACTERIZED
PROTEIN

(Cytophaga
hutchinsonii) 		PF14534
(DUF4440) 		3 LEU A  30
LEU A  14
ARG A 102
 None
 0.47A 6fgcA-2r4iA:
undetectable		 6fgcA-2r4iA:
15.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r4j AEROBIC
GLYCEROL-3-PHOSPHATE
DEHYDROGENASE

(Escherichia
coli) 		PF01266
(DAO)
PF16901
(DAO_C) 		3 LEU A  75
LEU A 117
ARG A  71
 None
 0.69A 6fgcA-2r4jA:
5.0		 6fgcA-2r4jA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r9z GLUTATHIONE AMIDE
REDUCTASE

(Marichromatium
gracile) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		3 LEU A 362
LEU A 353
ARG A 361
 None
 0.64A 6fgcA-2r9zA:
undetectable		 6fgcA-2r9zA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rdg SUPERANTIGEN-LIKE
PROTEIN 11

(Staphylococcus
aureus) 		PF02876
(Stap_Strp_tox_C)
PF09199
(SSL_OB) 		3 LEU A 141
LEU A 171
ARG A 138
 None
 0.58A 6fgcA-2rdgA:
undetectable		 6fgcA-2rdgA:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rjt BETA-KETOACYL-ACP
SYNTHASE II

(Streptococcus
pneumoniae) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		3 LEU A  96
LEU A  91
ARG A 249
 None
 0.61A 6fgcA-2rjtA:
1.2		 6fgcA-2rjtA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2tnf PROTEIN (TUMOR
NECROSIS FACTOR
ALPHA)

(Mus musculus) 		PF00229
(TNF) 		3 LEU A 132
LEU A 126
ARG A  82
 None
 0.66A 6fgcA-2tnfA:
undetectable		 6fgcA-2tnfA:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wvl MANNOSYL-3-PHOSPHOGL
YCERATE SYNTHASE

(Thermus
thermophilus) 		PF09488
(Osmo_MPGsynth) 		3 LEU A  17
LEU A 275
ARG A 198
 None
 0.55A 6fgcA-2wvlA:
2.3		 6fgcA-2wvlA:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yqy HYPOTHETICAL PROTEIN
TTHA0303

(Thermus
thermophilus) 		PF12867
(DinB_2) 		3 LEU A  28
LEU A 113
ARG A  21
 None
 0.68A 6fgcA-2yqyA:
undetectable		 6fgcA-2yqyA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3chl ALPHA-14 GIARDIN

(Giardia
intestinalis) 		PF00191
(Annexin) 		3 LEU A  32
LEU A  67
ARG A  29
 None
 0.58A 6fgcA-3chlA:
undetectable		 6fgcA-3chlA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cp8 TRNA URIDINE
5-CARBOXYMETHYLAMINO
METHYL MODIFICATION
ENZYME GIDA

(Chlorobaculum
tepidum) 		PF01134
(GIDA)
PF13932
(GIDA_assoc) 		3 LEU A 615
LEU A 579
ARG A 618
 None
 0.68A 6fgcA-3cp8A:
undetectable		 6fgcA-3cp8A:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dao PUTATIVE PHOSPHATE

([Eubacterium]
rectale) 		PF08282
(Hydrolase_3) 		3 LEU A  62
LEU A  78
ARG A 203
 None
 0.58A 6fgcA-3daoA:
undetectable		 6fgcA-3daoA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dcf TRANSCRIPTIONAL
REGULATOR OF THE
TETR/ACRR FAMILY

(Thermobifida
fusca) 		PF00440
(TetR_N) 		3 LEU A 110
LEU A 157
ARG A 106
 None
 0.57A 6fgcA-3dcfA:
undetectable		 6fgcA-3dcfA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f41 PHYTASE

(Mitsuokella
multacida) 		PF14566
(PTPlike_phytase) 		3 LEU A 582
LEU A 393
ARG A 578
 None
 0.68A 6fgcA-3f41A:
undetectable		 6fgcA-3f41A:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fgw PUTATIVE
PHOSPHOLIPASE B-LIKE
2

(Mus musculus) 		PF04916
(Phospholip_B) 		3 LEU A 552
LEU A 545
ARG A 590
 None
 0.70A 6fgcA-3fgwA:
undetectable		 6fgcA-3fgwA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fsd NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION IN
NUTRIENT UPTAKE

(Rhodospirillum
rubrum) 		PF14534
(DUF4440) 		3 LEU A  38
LEU A  22
ARG A 111
 None
 0.57A 6fgcA-3fsdA:
undetectable		 6fgcA-3fsdA:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fyb PROTEIN OF UNKNOWN
FUNCTION (DUF1244)

(Alcanivorax
borkumensis) 		PF06844
(DUF1244) 		3 LEU A  46
LEU A  24
ARG A  43
 None
 0.68A 6fgcA-3fybA:
undetectable		 6fgcA-3fybA:
13.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hwc CHLOROPHENOL-4-MONOO
XYGENASE COMPONENT 2

(Burkholderia
cepacia) 		PF03241
(HpaB)
PF11794
(HpaB_N) 		3 LEU A3306
LEU A3430
ARG A3299
 None
 0.45A 6fgcA-3hwcA:
undetectable		 6fgcA-3hwcA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jc7 DNA REPLICATION
COMPLEX GINS PROTEIN
SLD5

(Saccharomyces
cerevisiae) 		PF05916
(Sld5)
PF16922
(SLD5_C) 		3 LEU D 136
LEU D  87
ARG D  90
 None
 0.66A 6fgcA-3jc7D:
undetectable		 6fgcA-3jc7D:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kls EXOTOXIN 1

(Staphylococcus
aureus) 		PF02876
(Stap_Strp_tox_C)
PF09199
(SSL_OB) 		3 LEU X 173
LEU X 203
ARG X 170
 None
 0.66A 6fgcA-3klsX:
undetectable		 6fgcA-3klsX:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l3b ES1 FAMILY PROTEIN

(Ehrlichia
chaffeensis) 		PF01965
(DJ-1_PfpI) 		3 LEU A  25
LEU A 200
ARG A  21
 None
 0.51A 6fgcA-3l3bA:
4.1		 6fgcA-3l3bA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o13 SUPERANTIGEN-LIKE
PROTEIN

(Staphylococcus
aureus) 		PF02876
(Stap_Strp_tox_C)
PF09199
(SSL_OB) 		3 LEU A 172
LEU A 202
ARG A 169
 None
 0.62A 6fgcA-3o13A:
undetectable		 6fgcA-3o13A:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q10 PANTOATE--BETA-ALANI
NE LIGASE

(Yersinia pestis) 		PF02569
(Pantoate_ligase) 		3 LEU A 254
LEU A 282
ARG A 220
 None
 0.54A 6fgcA-3q10A:
undetectable		 6fgcA-3q10A:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q98 TRANSCARBAMYLASE

(Escherichia
coli) 		PF00185
(OTCace)
PF02729
(OTCace_N) 		3 LEU A 293
LEU A 285
ARG A 281
 None
 0.61A 6fgcA-3q98A:
3.4		 6fgcA-3q98A:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r2i EXOTOXIN 5

(Staphylococcus
aureus) 		PF02876
(Stap_Strp_tox_C)
PF09199
(SSL_OB) 		3 LEU A 176
LEU A 206
ARG A 173
 None
 0.67A 6fgcA-3r2iA:
undetectable		 6fgcA-3r2iA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r2t PUTATIVE
UNCHARACTERIZED
PROTEIN

(Staphylococcus
aureus) 		PF02876
(Stap_Strp_tox_C)
PF09199
(SSL_OB) 		3 LEU A 176
LEU A 206
ARG A 173
 None
 0.63A 6fgcA-3r2tA:
undetectable		 6fgcA-3r2tA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3smt HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD3

(Homo sapiens) 		PF00856
(SET)
PF09273
(Rubis-subs-bind) 		3 LEU A 160
LEU A 178
ARG A 253
 None
None
SAM  A1000 (-2.7A)
 0.68A 6fgcA-3smtA:
undetectable		 6fgcA-3smtA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ury EXOTOXIN

(Staphylococcus
aureus) 		PF02876
(Stap_Strp_tox_C)
PF09199
(SSL_OB) 		3 LEU A 253
LEU A 282
ARG A 250
 None
 0.66A 6fgcA-3uryA:
undetectable		 6fgcA-3uryA:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3x1d ATLASTIN

(Drosophila
melanogaster) 		PF02263
(GBP) 		3 LEU A 275
LEU A  54
ARG A 192
 None
None
GDP  A 601 (-4.4A)
 0.70A 6fgcA-3x1dA:
2.6		 6fgcA-3x1dA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ag6 TYPE IV SECRETORY
PATHWAY VIRB4
COMPONENTS-LIKE
PROTEIN

(Thermoanaerobacter
pseudethanolicus) 		PF01935
(DUF87) 		3 LEU A 533
LEU A 550
ARG A 574
 None
 0.70A 6fgcA-4ag6A:
2.2		 6fgcA-4ag6A:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b9d SERINE/THREONINE-PRO
TEIN KINASE NEK1

(Homo sapiens) 		PF00069
(Pkinase) 		3 LEU A  88
LEU A 136
ARG A  91
 None
 0.67A 6fgcA-4b9dA:
undetectable		 6fgcA-4b9dA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4da5 CHOLINE KINASE ALPHA

(Homo sapiens) 		PF01633
(Choline_kinase) 		3 LEU A 414
LEU A 292
ARG A 411
 None
 0.57A 6fgcA-4da5A:
undetectable		 6fgcA-4da5A:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4frt PROBABLE PORIN

(Pseudomonas
aeruginosa) 		PF03573
(OprD) 		3 LEU A  39
LEU A  58
ARG A  41
 None
 0.69A 6fgcA-4frtA:
undetectable		 6fgcA-4frtA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g34 EUKARYOTIC
TRANSLATION
INITIATION FACTOR
2-ALPHA KINASE 3

(Homo sapiens) 		PF00069
(Pkinase) 		3 LEU A1017
LEU A 914
ARG A 910
 None
 0.63A 6fgcA-4g34A:
undetectable		 6fgcA-4g34A:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g9b BETA-PHOSPHOGLUCOMUT
ASE

(Escherichia
coli) 		PF13419
(HAD_2) 		3 LEU A  74
LEU A  57
ARG A  71
 None
 0.70A 6fgcA-4g9bA:
undetectable		 6fgcA-4g9bA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iwn TRNA
(CMO5U34)-METHYLTRAN
SFERASE

(Escherichia
coli) 		PF13649
(Methyltransf_25) 		3 LEU A 146
LEU A 138
ARG A 119
 None
None
GEK  A 301 ( 3.6A)
 0.70A 6fgcA-4iwnA:
undetectable		 6fgcA-4iwnA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m9x CELL DEATH PROTEIN 4

(Caenorhabditis
elegans) 		PF00619
(CARD)
PF00931
(NB-ARC) 		3 LEU A 239
LEU A 211
ARG A 242
 None
 0.62A 6fgcA-4m9xA:
1.9		 6fgcA-4m9xA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mgg MUCONATE LACTONIZING
ENZYME

(Labrenzia
aggregata) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		3 LEU A 264
LEU A 307
ARG A 279
 None
 0.51A 6fgcA-4mggA:
undetectable		 6fgcA-4mggA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nnb OBCA, OXALATE
BIOSYNTHETIC
COMPONENT A

(Burkholderia
glumae) 		PF05853
(BKACE) 		3 LEU A 423
LEU A 408
ARG A 419
 None
 0.55A 6fgcA-4nnbA:
undetectable		 6fgcA-4nnbA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ohj TOXIC SHOCK SYNDROME
TOXIN-1

(Staphylococcus
aureus) 		PF02876
(Stap_Strp_tox_C) 		3 LEU A 177
LEU A 208
ARG A 174
 None
 0.70A 6fgcA-4ohjA:
undetectable		 6fgcA-4ohjA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oqj PKS

(Streptomyces
albus) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		3 LEU A 622
LEU A 630
ARG A 619
 None
 0.68A 6fgcA-4oqjA:
undetectable		 6fgcA-4oqjA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pc9 C4-DICARBOXYLATE
TRANSPORT SYSTEM,
SUBSTRATE-BINDING
PROTEIN, PUTATIVE

(Roseobacter
denitrificans) 		PF03480
(DctP) 		3 LEU A 277
LEU A 115
ARG A 270
 None
 0.68A 6fgcA-4pc9A:
undetectable		 6fgcA-4pc9A:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q2b ENDO-1,4-BETA-D-GLUC
ANASE

(Pseudomonas
putida) 		PF01270
(Glyco_hydro_8) 		3 LEU A 156
LEU A 164
ARG A 154
 None
 0.59A 6fgcA-4q2bA:
undetectable		 6fgcA-4q2bA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qjy GH127
BETA-L-ARABINOFURANO
SIDASE

(Geobacillus
stearothermophilus) 		PF07944
(Glyco_hydro_127) 		3 LEU A 546
LEU A 569
ARG A 530
 None
 0.63A 6fgcA-4qjyA:
undetectable		 6fgcA-4qjyA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qn9 N-ACYL-PHOSPHATIDYLE
THANOLAMINE-HYDROLYZ
ING PHOSPHOLIPASE D

(Homo sapiens) 		PF12706
(Lactamase_B_2) 		3 LEU A 215
LEU A 191
ARG A 257
 None
 0.58A 6fgcA-4qn9A:
undetectable		 6fgcA-4qn9A:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rco PUTATIVE
UNCHARACTERIZED
PROTEIN

(Staphylococcus
aureus) 		PF02876
(Stap_Strp_tox_C)
PF09199
(SSL_OB) 		3 LEU A 253
LEU A 282
ARG A 250
 None
 0.66A 6fgcA-4rcoA:
undetectable		 6fgcA-4rcoA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rgt PUTATIVE
UNCHARACTERIZED
PROTEIN

(Staphylococcus
aureus) 		PF02876
(Stap_Strp_tox_C)
PF09199
(SSL_OB) 		3 LEU A 172
LEU A 203
ARG A 169
 None
 0.61A 6fgcA-4rgtA:
undetectable		 6fgcA-4rgtA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tpt LIM DOMAIN KINASE 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		3 LEU A 403
LEU A 472
ARG A 364
 35H  A 701 ( 4.2A)
35H  A 701 (-3.7A)
None
 0.58A 6fgcA-4tptA:
undetectable		 6fgcA-4tptA:
20.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4u90 GEPHYRIN

(Rattus
norvegicus) 		PF00994
(MoCF_biosynth)
PF03453
(MoeA_N)
PF03454
(MoeA_C) 		3 LEU A 323
LEU A 605
ARG A 670
 None
 0.33A 6fgcA-4u90A:
51.0		 6fgcA-4u90A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xz7 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Streptococcus
suis) 		PF01841
(Transglut_core) 		3 LEU A  94
LEU A  64
ARG A  91
 None
 0.70A 6fgcA-4xz7A:
undetectable		 6fgcA-4xz7A:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y93 NON-SPECIFIC
PROTEIN-TYROSINE
KINASE,NON-SPECIFIC
PROTEIN-TYROSINE
KINASE

(Bos taurus) 		PF00169
(PH)
PF00779
(BTK)
PF07714
(Pkinase_Tyr) 		3 LEU A  29
LEU A  31
ARG A  49
 None
 0.61A 6fgcA-4y93A:
undetectable		 6fgcA-4y93A:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yla AROMATIC
PRENYLTRANSFERASE

(Marinactinospora
thermotolerans) 		PF11991
(Trp_DMAT) 		3 LEU A 143
LEU A 224
ARG A 139
 None
 0.56A 6fgcA-4ylaA:
undetectable		 6fgcA-4ylaA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zch TUMOR NECROSIS
FACTOR LIGAND
SUPERFAMILY MEMBER
13,TUMOR NECROSIS
FACTOR LIGAND
SUPERFAMILY MEMBER
13B,TUMOR NECROSIS
FACTOR LIGAND
SUPERFAMILY MEMBER
13B

(Homo sapiens) 		PF00229
(TNF) 		3 LEU A 267
LEU A 261
ARG A 222
 None
 0.70A 6fgcA-4zchA:
undetectable		 6fgcA-4zchA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zi9 MCG133388, ISOFORM
CRA_T

(Mus musculus) 		PF00028
(Cadherin)
PF08266
(Cadherin_2) 		3 LEU A  46
LEU A  67
ARG A  43
 None
 0.69A 6fgcA-4zi9A:
undetectable		 6fgcA-4zi9A:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5awm STRESS-ACTIVATED
PROTEIN KINASE JNK

(Drosophila
melanogaster) 		PF00069
(Pkinase) 		3 LEU A 129
LEU A 121
ARG A 125
 None
 0.45A 6fgcA-5awmA:
undetectable		 6fgcA-5awmA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c9e SEPL

(Escherichia
coli) 		PF07201
(HrpJ) 		3 LEU A 219
LEU A 256
ARG A 215
 None
 0.61A 6fgcA-5c9eA:
undetectable		 6fgcA-5c9eA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d3i STAPHYLOCOCCAL
SUPERANTIGEN-LIKE
PROTEIN 3

(Staphylococcus
aureus) 		PF02876
(Stap_Strp_tox_C)
PF09199
(SSL_OB) 		3 LEU B 271
LEU B 300
ARG B 268
 None
 0.65A 6fgcA-5d3iB:
undetectable		 6fgcA-5d3iB:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e5u CONTACTIN-6

(Mus musculus) 		PF13927
(Ig_3) 		3 LEU B 181
LEU B 164
ARG B 172
 None
ACY  B 401 ( 4.8A)
ACY  B 401 ( 2.6A)
 0.66A 6fgcA-5e5uB:
undetectable		 6fgcA-5e5uB:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fka STAPHYLOCOCCAL
ENTEROTOXIN E

(Staphylococcus
aureus) 		PF01123
(Stap_Strp_toxin)
PF02876
(Stap_Strp_tox_C) 		3 LEU C 163
LEU C 198
ARG C 160
 None
 0.58A 6fgcA-5fkaC:
undetectable		 6fgcA-5fkaC:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fqe BETA-N-ACETYLGALACTO
SAMINIDASE

(Clostridium
perfringens) 		PF13320
(DUF4091) 		3 LEU A 506
LEU A 484
ARG A 502
 None
 0.66A 6fgcA-5fqeA:
undetectable		 6fgcA-5fqeA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ftg CHOLINE KINASE ALPHA

(Homo sapiens) 		PF01633
(Choline_kinase) 		3 LEU A 414
LEU A 292
ARG A 411
 None
 0.64A 6fgcA-5ftgA:
undetectable		 6fgcA-5ftgA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gw5 T-COMPLEX PROTEIN 1
SUBUNIT DELTA

(Saccharomyces
cerevisiae) 		PF00118
(Cpn60_TCP1) 		3 LEU d 150
LEU d 179
ARG d 147
 None
 0.70A 6fgcA-5gw5d:
undetectable		 6fgcA-5gw5d:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i4d SUPERANTIGEN-LIKE
PROTEIN

(Staphylococcus
aureus) 		PF02876
(Stap_Strp_tox_C)
PF09199
(SSL_OB) 		3 LEU A 301
LEU A 330
ARG A 298
 None
 0.63A 6fgcA-5i4dA:
undetectable		 6fgcA-5i4dA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ioj HALOALKYLPHOSPHORUS
HYDROLASE

(Sphingobium sp.
TCM1) 		no annotation 3 LEU A 487
LEU A 577
ARG A 503
 None
 0.68A 6fgcA-5iojA:
undetectable		 6fgcA-5iojA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5it3 LYSINE-SPECIFIC
HISTONE DEMETHYLASE
1A

(Homo sapiens) 		PF04433
(SWIRM) 		3 LEU A 261
LEU A 183
ARG A 214
 None
 0.52A 6fgcA-5it3A:
undetectable		 6fgcA-5it3A:
12.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ken EBOLA SURFACE
GLYCOPROTEIN, GP1

(Zaire
ebolavirus) 		PF01611
(Filo_glycop) 		3 LEU A 184
LEU A 186
ARG A  64
 None
 0.68A 6fgcA-5kenA:
undetectable		 6fgcA-5kenA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l3d LYSINE-SPECIFIC
HISTONE DEMETHYLASE
1A

(Homo sapiens) 		PF01593
(Amino_oxidase)
PF04433
(SWIRM) 		3 LEU A 261
LEU A 183
ARG A 214
 None
 0.51A 6fgcA-5l3dA:
undetectable		 6fgcA-5l3dA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lf9 NUCLEOSIDE
DIPHOSPHATE-LINKED
MOIETY X MOTIF 22

(Homo sapiens) 		no annotation 3 LEU A 102
LEU A  34
ARG A  31
 None
 0.53A 6fgcA-5lf9A:
undetectable		 6fgcA-5lf9A:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mwr TETR FAMILY
TRANSCRIPTIONAL
REGULATOR

(Sulfolobus
acidocaldarius) 		no annotation 3 LEU A 193
LEU A 137
ARG A  86
 None
PTR  A 133 ( 3.6A)
PTR  A 133 ( 4.3A)
 0.60A 6fgcA-5mwrA:
undetectable		 6fgcA-5mwrA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tws HUMAN DNA POLYMERASE
MU

(Homo sapiens) 		PF10391
(DNA_pol_lambd_f)
PF14716
(HHH_8)
PF14791
(DNA_pol_B_thumb)
PF14792
(DNA_pol_B_palm) 		3 LEU A 444
LEU A 432
ARG A 492
 None
 0.52A 6fgcA-5twsA:
undetectable		 6fgcA-5twsA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v4r LA-RELATED PROTEIN 1

(Homo sapiens) 		no annotation 3 LEU A 838
LEU A 821
ARG A 817
 None
 0.69A 6fgcA-5v4rA:
undetectable		 6fgcA-5v4rA:
16.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wlh LBACAS13A H328A
(C2C2)

(Lachnospiraceae
bacterium
NK4A179) 		no annotation 3 LEU A 900
LEU A 890
ARG A 893
 None
 0.70A 6fgcA-5wlhA:
undetectable		 6fgcA-5wlhA:
12.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xly CYCLIC DIGUANOSINE
MONOPHOSPHATE-BINDIN
G PROTEIN PA4608

(Pseudomonas
aeruginosa) 		PF07238
(PilZ) 		3 LEU B  38
LEU B 112
ARG B  99
 None
 0.64A 6fgcA-5xlyB:
undetectable		 6fgcA-5xlyB:
14.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yti FLAGELLAR HOOK
ASSOCIATED PROTEIN
TYPE 3 FLGL

(Legionella
pneumophila) 		no annotation 3 LEU A 352
LEU A  73
ARG A 348
 None
 0.61A 6fgcA-5ytiA:
undetectable		 6fgcA-5ytiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bgi ANOCTAMIN-1

(Mus musculus) 		no annotation 3 LEU A 861
LEU A 857
ARG A 860
 None
 0.63A 6fgcA-6bgiA:
undetectable		 6fgcA-6bgiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bhu MULTIDRUG
RESISTANCE-ASSOCIATE
D PROTEIN 1

(Bos taurus) 		no annotation 3 LEU A 824
LEU A 673
ARG A 822
 None
 0.66A 6fgcA-6bhuA:
undetectable		 6fgcA-6bhuA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6etz BETA-GALACTOSIDASE

(Arthrobacter
sp. 32cB) 		no annotation 3 LEU A 963
LEU A 954
ARG A 947
 None
 0.58A 6fgcA-6etzA:
undetectable		 6fgcA-6etzA:
undetectable