SIMILAR PATTERNS OF AMINO ACIDS FOR 6FGC_A_ACTA810_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ad6 RETINOBLASTOMA TUMOR
SUPPRESSOR

(Homo sapiens) 		PF01858
(RB_A) 		3 LEU A 476
SER A 474
PHE A 473
 None
 0.66A 6fgcA-1ad6A:
undetectable		 6fgcA-1ad6A:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b0b HEMOGLOBIN

(Phacoides
pectinatus) 		PF00042
(Globin) 		3 LEU A  46
SER A  44
PHE A  43
 HEM  A 144 ( 3.9A)
None
HEM  A 144 ( 3.8A)
 0.60A 6fgcA-1b0bA:
undetectable		 6fgcA-1b0bA:
16.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b9y PROTEIN (PHOSDUCIN)

(Rattus
norvegicus) 		PF02114
(Phosducin) 		3 LEU C 221
SER C 219
PHE C 220
 None
 0.66A 6fgcA-1b9yC:
undetectable		 6fgcA-1b9yC:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bd8 P19INK4D CDK4/6
INHIBITOR

(Homo sapiens) 		PF12796
(Ank_2) 		3 LEU A 126
SER A 124
PHE A 125
 None
 0.67A 6fgcA-1bd8A:
undetectable		 6fgcA-1bd8A:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ce7 PROTEIN
(RIBOSOME-INACTIVATI
NG PROTEIN TYPE II)

(Viscum album) 		PF00161
(RIP) 		3 LEU A  39
SER A  41
PHE A 239
 None
 0.65A 6fgcA-1ce7A:
0.8		 6fgcA-1ce7A:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cjy PROTEIN (CYTOSOLIC
PHOSPHOLIPASE A2)

(Homo sapiens) 		PF00168
(C2)
PF01735
(PLA2_B) 		3 LEU A 642
SER A 577
PHE A 576
 None
 0.60A 6fgcA-1cjyA:
4.6		 6fgcA-1cjyA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cyd CARBONYL REDUCTASE

(Mus musculus) 		PF13561
(adh_short_C2) 		3 LEU A 108
SER A 105
PHE A 104
 None
 0.60A 6fgcA-1cydA:
2.8		 6fgcA-1cydA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dju AROMATIC
AMINOTRANSFERASE

(Pyrococcus
horikoshii) 		PF00155
(Aminotran_1_2) 		3 LEU A 330
SER A 332
PHE A 335
 None
 0.64A 6fgcA-1djuA:
0.8		 6fgcA-1djuA:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lwh 4-ALPHA-GLUCANOTRANS
FERASE

(Thermotoga
maritima) 		PF00128
(Alpha-amylase)
PF09178
(DUF1945) 		3 LEU A 301
SER A 299
PHE A 302
 None
 0.67A 6fgcA-1lwhA:
undetectable		 6fgcA-1lwhA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n76 LACTOFERRIN

(Homo sapiens) 		PF00405
(Transferrin) 		3 LEU A 320
SER A 322
PHE A 325
 None
 0.52A 6fgcA-1n76A:
1.2		 6fgcA-1n76A:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1opc OMPR

(Escherichia
coli) 		PF00486
(Trans_reg_C) 		3 LEU A 161
SER A 163
PHE A 166
 None
 0.54A 6fgcA-1opcA:
undetectable		 6fgcA-1opcA:
13.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pfd FERREDOXIN

(Petroselinum
crispum) 		PF00111
(Fer2) 		3 LEU A  64
SER A  62
PHE A  63
 None
 0.61A 6fgcA-1pfdA:
undetectable		 6fgcA-1pfdA:
13.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pyt CHYMOTRYPSINOGEN C

(Bos taurus) 		PF00089
(Trypsin) 		3 LEU D 798
SER D 796
PHE D 797
 None
 0.53A 6fgcA-1pytD:
undetectable		 6fgcA-1pytD:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q2f PNC27

(-) 		PF08563
(P53_TAD) 		3 LEU A  11
SER A   9
PHE A   8
 None
 0.59A 6fgcA-1q2fA:
undetectable		 6fgcA-1q2fA:
5.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q5a EP-CADHERIN

(Mus musculus) 		PF00028
(Cadherin) 		3 LEU A 174
SER A 173
PHE A 163
 None
 0.00A 6fgcA-1q5aA:
undetectable		 6fgcA-1q5aA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qpi PROTEIN
(TETRACYCLINE
REPRESSOR)

(Escherichia
coli) 		PF00440
(TetR_N)
PF02909
(TetR_C) 		3 LEU A  79
SER A  77
PHE A  78
 None
 0.62A 6fgcA-1qpiA:
undetectable		 6fgcA-1qpiA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rhi HUMAN RHINOVIRUS 3
COAT PROTEIN

(Rhinovirus B) 		PF00073
(Rhv) 		3 LEU 1  71
SER 1  69
PHE 1  70
 None
 0.59A 6fgcA-1rhi1:
undetectable		 6fgcA-1rhi1:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vav ALGINATE LYASE
PA1167

(Pseudomonas
aeruginosa) 		PF08787
(Alginate_lyase2) 		3 LEU A 218
SER A 216
PHE A 215
 None
 0.56A 6fgcA-1vavA:
undetectable		 6fgcA-1vavA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vq0 33 KDA CHAPERONIN

(Thermotoga
maritima) 		PF01430
(HSP33) 		3 LEU A 201
SER A 199
PHE A 202
 None
 0.63A 6fgcA-1vq0A:
undetectable		 6fgcA-1vq0A:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wr7 NEDD4-2

(Mus musculus) 		PF00397
(WW) 		3 LEU A   9
SER A   7
PHE A   8
 None
 0.43A 6fgcA-1wr7A:
undetectable		 6fgcA-1wr7A:
7.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x67 DREBRIN-LIKE PROTEIN

(Homo sapiens) 		PF00241
(Cofilin_ADF) 		3 LEU A 115
SER A 113
PHE A 114
 None
 0.60A 6fgcA-1x67A:
undetectable		 6fgcA-1x67A:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yac YCAC GENE PRODUCT

(Escherichia
coli) 		PF00857
(Isochorismatase) 		3 LEU A 186
SER A 188
PHE A 187
 None
 0.67A 6fgcA-1yacA:
undetectable		 6fgcA-1yacA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aj4 GALACTOKINASE

(Saccharomyces
cerevisiae) 		PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C)
PF10509
(GalKase_gal_bdg) 		3 LEU A 138
SER A 136
PHE A 137
 None
 0.67A 6fgcA-2aj4A:
undetectable		 6fgcA-2aj4A:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cph RNA BINDING MOTIF
PROTEIN 19

(Mus musculus) 		PF00076
(RRM_1) 		3 LEU A 481
SER A 483
PHE A 482
 None
 0.67A 6fgcA-2cphA:
undetectable		 6fgcA-2cphA:
12.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cxe RIBULOSE
BISPHOSPHATE
CARBOXYLASE

(Pyrococcus
horikoshii) 		PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N) 		3 LEU A 101
SER A 103
PHE A 102
 None
 0.64A 6fgcA-2cxeA:
2.1		 6fgcA-2cxeA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d2n GIANT HEMOGLOBIN,
B2(C) GLOBIN CHAIN

(Oligobrachia
mashikoi) 		PF00042
(Globin) 		3 LEU C  39
SER C  41
PHE C  40
 None
 0.59A 6fgcA-2d2nC:
undetectable		 6fgcA-2d2nC:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2db3 ATP-DEPENDENT RNA
HELICASE VASA

(Drosophila
melanogaster) 		PF00270
(DEAD)
PF00271
(Helicase_C) 		3 LEU A 509
SER A 507
PHE A 508
 None
 0.67A 6fgcA-2db3A:
undetectable		 6fgcA-2db3A:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dcr PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE FES/FPS

(Homo sapiens) 		PF00017
(SH2) 		3 LEU A  84
SER A  80
PHE A  78
 None
 0.61A 6fgcA-2dcrA:
undetectable		 6fgcA-2dcrA:
15.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dmi TEASHIRT HOMOLOG 3

(Homo sapiens) 		PF00096
(zf-C2H2)
PF12756
(zf-C2H2_2) 		3 LEU A  96
SER A  92
PHE A  90
 None
 0.66A 6fgcA-2dmiA:
undetectable		 6fgcA-2dmiA:
14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e0q THIOREDOXIN

(Sulfurisphaera
tokodaii) 		PF00085
(Thioredoxin) 		3 LEU A  40
SER A  42
PHE A  45
 None
 0.53A 6fgcA-2e0qA:
undetectable		 6fgcA-2e0qA:
15.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f42 STIP1 HOMOLOGY AND
U-BOX CONTAINING
PROTEIN 1

(Danio rerio) 		PF04564
(U-box) 		3 LEU A 195
SER A 197
PHE A 196
 None
 0.67A 6fgcA-2f42A:
undetectable		 6fgcA-2f42A:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g5x RIBOSOME-INACTIVATIN
G PROTEIN

(Silene
chalcedonica) 		PF00161
(RIP) 		3 LEU A  17
SER A  15
PHE A  16
 None
 0.67A 6fgcA-2g5xA:
undetectable		 6fgcA-2g5xA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gam BETA-1,6-N-ACETYLGLU
COSAMINYLTRANSFERASE

(Mus musculus) 		PF02485
(Branch) 		3 LEU A 282
SER A 284
PHE A 321
 None
 0.54A 6fgcA-2gamA:
undetectable		 6fgcA-2gamA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hxs RAS-RELATED PROTEIN
RAB-28

(Homo sapiens) 		PF00071
(Ras) 		3 LEU A 126
SER A 154
PHE A 153
 None
 0.67A 6fgcA-2hxsA:
undetectable		 6fgcA-2hxsA:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i3f GLYCOLIPID
TRANSFER-LIKE
PROTEIN

(Galdieria
sulphuraria) 		PF08718
(GLTP) 		3 LEU A 111
SER A 109
PHE A 110
 None
 0.62A 6fgcA-2i3fA:
undetectable		 6fgcA-2i3fA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2icg LIN2918 PROTEIN

(Listeria
innocua) 		PF14568
(SUKH_6) 		3 LEU A   6
SER A   4
PHE A   5
 None
 0.61A 6fgcA-2icgA:
undetectable		 6fgcA-2icgA:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j3t TRAFFICKING PROTEIN
PARTICLE COMPLEX
SUBUNIT 6A

(Homo sapiens) 		PF04051
(TRAPP) 		3 LEU B 103
SER B  99
PHE B 100
 None
 0.50A 6fgcA-2j3tB:
undetectable		 6fgcA-2j3tB:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kk6 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE FER

(Homo sapiens) 		PF00017
(SH2) 		3 LEU A  86
SER A  81
PHE A  80
 None
 0.63A 6fgcA-2kk6A:
undetectable		 6fgcA-2kk6A:
14.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kue SERINE/THREONINE-PRO
TEIN KINASE PKNB

(Mycobacterium
tuberculosis) 		PF03793
(PASTA) 		3 LEU A 553
SER A 521
PHE A 520
 None
 0.60A 6fgcA-2kueA:
undetectable		 6fgcA-2kueA:
17.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lbp LEUCINE-BINDING
PROTEIN

(Escherichia
coli) 		PF13458
(Peripla_BP_6) 		3 LEU A 185
SER A 183
PHE A 182
 None
 0.62A 6fgcA-2lbpA:
4.3		 6fgcA-2lbpA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2liv LEUCINE

(Escherichia
coli) 		PF13458
(Peripla_BP_6) 		3 LEU A 185
SER A 183
PHE A 182
 None
 0.63A 6fgcA-2livA:
5.5		 6fgcA-2livA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2n6j ZINC METALLOPROTEASE
ZMP1

(Clostridioides
difficile) 		PF07737
(ATLF) 		3 LEU A 215
SER A 213
PHE A 214
 None
 0.65A 6fgcA-2n6jA:
undetectable		 6fgcA-2n6jA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nlz CEPHALOSPORIN
ACYLASE

(Bacillus
halodurans) 		PF01019
(G_glu_transpept) 		3 LEU A 411
SER A 402
PHE A 401
 None
 0.61A 6fgcA-2nlzA:
undetectable		 6fgcA-2nlzA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o5f PUTATIVE NUDIX
HYDROLASE DR_0079

(Deinococcus
radiodurans) 		PF00293
(NUDIX) 		3 LEU A 112
SER A 106
PHE A 105
 None
 0.54A 6fgcA-2o5fA:
undetectable		 6fgcA-2o5fA:
16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2om5 CONTACTIN 2

(Homo sapiens) 		PF07679
(I-set)
PF13927
(Ig_3) 		3 LEU A 355
SER A 353
PHE A 352
 None
 0.56A 6fgcA-2om5A:
undetectable		 6fgcA-2om5A:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p3g MAP KINASE-ACTIVATED
PROTEIN KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		3 LEU X 146
SER X 148
PHE X 147
 None
 0.67A 6fgcA-2p3gX:
undetectable		 6fgcA-2p3gX:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pc6 PROBABLE
ACETOLACTATE
SYNTHASE ISOZYME III
(SMALL SUBUNIT)

(Nitrosomonas
europaea) 		PF10369
(ALS_ss_C)
PF13710
(ACT_5) 		3 LEU A  22
SER A  24
PHE A  23
 None
 0.63A 6fgcA-2pc6A:
undetectable		 6fgcA-2pc6A:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qw5 XYLOSE
ISOMERASE-LIKE TIM
BARREL

(Trichormus
variabilis) 		PF01261
(AP_endonuc_2) 		3 LEU A 266
SER A 264
PHE A 265
 None
 0.63A 6fgcA-2qw5A:
undetectable		 6fgcA-2qw5A:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rch CYTOCHROME P450 74A

(Arabidopsis
thaliana) 		PF00067
(p450) 		3 LEU A 513
SER A 511
PHE A 510
 None
 0.67A 6fgcA-2rchA:
undetectable		 6fgcA-2rchA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2tbv TOMATO BUSHY STUNT
VIRUS

(Tomato bushy
stunt virus) 		PF00729
(Viral_coat) 		3 LEU A 145
SER A 143
PHE A 142
 None
 0.61A 6fgcA-2tbvA:
undetectable		 6fgcA-2tbvA:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2tmk THYMIDYLATE KINASE

(Saccharomyces
cerevisiae) 		PF02223
(Thymidylate_kin) 		3 LEU A 124
SER A 214
PHE A 213
 None
 0.66A 6fgcA-2tmkA:
undetectable		 6fgcA-2tmkA:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vnu EXOSOME COMPLEX
EXONUCLEASE RRP44

(Saccharomyces
cerevisiae) 		PF00773
(RNB)
PF17215
(Rrp44_S1)
PF17216
(Rrp44_CSD1) 		3 LEU D 334
SER D 336
PHE D 339
 None
 0.65A 6fgcA-2vnuD:
undetectable		 6fgcA-2vnuD:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vxz PYRSV_GP04

(Pyrobaculum
spherical virus) 		no annotation 3 LEU A 131
SER A 129
PHE A 130
 None
 0.65A 6fgcA-2vxzA:
undetectable		 6fgcA-2vxzA:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w4i GLUTAMATE RACEMASE

(Helicobacter
pylori) 		PF01177
(Asp_Glu_race) 		3 LEU A  16
SER A  14
PHE A  13
 None
 0.65A 6fgcA-2w4iA:
3.9		 6fgcA-2w4iA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wp8 EXOSOME COMPLEX
EXONUCLEASE DIS3

(Saccharomyces
cerevisiae) 		PF00773
(RNB)
PF13638
(PIN_4)
PF17215
(Rrp44_S1)
PF17216
(Rrp44_CSD1) 		3 LEU J 334
SER J 336
PHE J 339
 None
 0.55A 6fgcA-2wp8J:
undetectable		 6fgcA-2wp8J:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x2u PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET

(Homo sapiens) 		PF00028
(Cadherin) 		3 LEU A  40
SER A 148
PHE A 147
 None
BU1  A1294 (-3.3A)
None
 0.59A 6fgcA-2x2uA:
undetectable		 6fgcA-2x2uA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x5d PROBABLE
AMINOTRANSFERASE

(Pseudomonas
aeruginosa) 		PF00155
(Aminotran_1_2) 		3 LEU A 341
SER A 343
PHE A 346
 None
 0.65A 6fgcA-2x5dA:
undetectable		 6fgcA-2x5dA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x9o 15,16-DIHYDROBILIVER
DIN-FERREDOXIN
OXIDOREDUCTASE

(Synechococcus
sp. WH 8020) 		PF05996
(Fe_bilin_red) 		3 LEU A 117
SER A 115
PHE A 114
 None
 0.67A 6fgcA-2x9oA:
undetectable		 6fgcA-2x9oA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zat DEHYDROGENASE/REDUCT
ASE SDR FAMILY
MEMBER 4

(Sus scrofa) 		PF13561
(adh_short_C2) 		3 LEU A 237
SER A 235
PHE A 236
 None
 0.65A 6fgcA-2zatA:
2.3		 6fgcA-2zatA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zwa LEUCINE CARBOXYL
METHYLTRANSFERASE 2

(Saccharomyces
cerevisiae) 		PF04072
(LCM)
PF13418
(Kelch_4) 		3 LEU A 197
SER A 200
PHE A 203
 SAH  A 801 (-3.7A)
None
None
 0.64A 6fgcA-2zwaA:
undetectable		 6fgcA-2zwaA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3am3 ENOYL-ACP REDUCTASE

(Plasmodium
falciparum) 		PF13561
(adh_short_C2) 		3 LEU A 398
SER A 396
PHE A 397
 None
 0.67A 6fgcA-3am3A:
2.7		 6fgcA-3am3A:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bci DISULFIDE BOND
PROTEIN A

(Staphylococcus
aureus) 		PF13462
(Thioredoxin_4) 		3 LEU A  83
SER A  81
PHE A  82
 None
 0.61A 6fgcA-3bciA:
undetectable		 6fgcA-3bciA:
17.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ce2 PUTATIVE PEPTIDASE

(Chlamydia
abortus) 		PF01432
(Peptidase_M3)
PF08439
(Peptidase_M3_N) 		3 LEU A  74
SER A  76
PHE A  75
 None
 0.58A 6fgcA-3ce2A:
undetectable		 6fgcA-3ce2A:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cx3 LIPOPROTEIN

(Streptococcus
pneumoniae) 		PF01297
(ZnuA) 		3 LEU A 217
SER A 215
PHE A 214
 None
 0.56A 6fgcA-3cx3A:
undetectable		 6fgcA-3cx3A:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g79 NDP-N-ACETYL-D-GALAC
TOSAMINURONIC ACID
DEHYDROGENASE

(Methanosarcina
mazei) 		PF00984
(UDPG_MGDP_dh)
PF03720
(UDPG_MGDP_dh_C)
PF03721
(UDPG_MGDP_dh_N) 		3 LEU A 126
SER A 124
PHE A 123
 None
 0.61A 6fgcA-3g79A:
undetectable		 6fgcA-3g79A:
25.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gfo COBALT IMPORT
ATP-BINDING PROTEIN
CBIO 1

(Clostridium
perfringens) 		PF00005
(ABC_tran) 		3 LEU A  48
SER A  46
PHE A  49
 None
SO4  A 274 (-2.7A)
None
 0.66A 6fgcA-3gfoA:
undetectable		 6fgcA-3gfoA:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hhv THIOREDOXIN (TRXA-2)

(Sulfolobus
solfataricus) 		PF00085
(Thioredoxin) 		3 LEU A  36
SER A  38
PHE A  41
 None
 0.34A 6fgcA-3hhvA:
undetectable		 6fgcA-3hhvA:
15.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kt4 PKHD-TYPE
HYDROXYLASE TPA1

(Saccharomyces
cerevisiae) 		PF10637
(Ofd1_CTDD)
PF13661
(2OG-FeII_Oxy_4) 		3 LEU A 371
SER A 369
PHE A 370
 None
 0.61A 6fgcA-3kt4A:
undetectable		 6fgcA-3kt4A:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nau ZINC FINGERS AND
HOMEOBOXES PROTEIN 2

(Homo sapiens) 		PF00046
(Homeobox) 		3 LEU A 459
SER A 457
PHE A 458
 None
 0.67A 6fgcA-3nauA:
undetectable		 6fgcA-3nauA:
9.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3om9 LACTATE
DEHYDROGENASE

(Toxoplasma
gondii) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		3 LEU A 262
SER A 260
PHE A 261
 None
 0.65A 6fgcA-3om9A:
2.5		 6fgcA-3om9A:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3onq REGULATOR OF
POLYKETIDE SYNTHASE
EXPRESSION

(Bifidobacterium
adolescentis) 		PF13556
(HTH_30) 		3 LEU A 121
SER A 116
PHE A 115
 None
 0.54A 6fgcA-3onqA:
undetectable		 6fgcA-3onqA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p11 RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-3

(Homo sapiens) 		PF00757
(Furin-like)
PF01030
(Recep_L_domain)
PF14843
(GF_recep_IV) 		3 LEU A 396
SER A 394
PHE A 393
 None
 0.61A 6fgcA-3p11A:
undetectable		 6fgcA-3p11A:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p11 RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-3

(Homo sapiens) 		PF00757
(Furin-like)
PF01030
(Recep_L_domain)
PF14843
(GF_recep_IV) 		3 LEU A 412
SER A 410
PHE A 409
 None
 0.51A 6fgcA-3p11A:
undetectable		 6fgcA-3p11A:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p7m MALATE DEHYDROGENASE

(Francisella
tularensis) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		3 LEU A 247
SER A 245
PHE A 246
 None
 0.64A 6fgcA-3p7mA:
3.7		 6fgcA-3p7mA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pov ORF 37

(Human
gammaherpesvirus
8) 		PF01771
(Herpes_alk_exo) 		3 LEU A 478
SER A 476
PHE A 475
 None
 0.64A 6fgcA-3povA:
undetectable		 6fgcA-3povA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q13 SPONDIN-1

(Homo sapiens) 		PF06468
(Spond_N) 		3 LEU A 379
SER A 381
PHE A 389
 None
 0.63A 6fgcA-3q13A:
undetectable		 6fgcA-3q13A:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q8d DNA REPAIR PROTEIN
RECO

(Escherichia
coli) 		PF02565
(RecO_C)
PF11967
(RecO_N) 		3 LEU A 109
SER A 107
PHE A 106
 None
 0.61A 6fgcA-3q8dA:
undetectable		 6fgcA-3q8dA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qo7 SERYL-TRNA
SYNTHETASE,
CYTOPLASMIC

(Candida
albicans) 		PF00587
(tRNA-synt_2b)
PF02403
(Seryl_tRNA_N) 		3 LEU A 199
SER A 197
PHE A 198
 None
 0.67A 6fgcA-3qo7A:
undetectable		 6fgcA-3qo7A:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3re2 PREDICTED PROTEIN

(Nematostella
vectensis) 		PF05053
(Menin) 		3 LEU A 121
SER A 119
PHE A 120
 None
 0.65A 6fgcA-3re2A:
undetectable		 6fgcA-3re2A:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rg1 CD180 MOLECULE

(Bos taurus) 		PF00560
(LRR_1)
PF13855
(LRR_8) 		3 LEU A 289
SER A 287
PHE A 286
 None
 0.47A 6fgcA-3rg1A:
undetectable		 6fgcA-3rg1A:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t63 PROTOCATECHUATE
3,4-DIOXYGENASE BETA
CHAIN

(Pseudomonas
putida) 		PF00775
(Dioxygenase_C)
PF12391
(PCDO_beta_N) 		3 LEU M 354
SER M 352
PHE M 351
 None
 0.54A 6fgcA-3t63M:
undetectable		 6fgcA-3t63M:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tij NUPC FAMILY PROTEIN

(Vibrio cholerae) 		PF01773
(Nucleos_tra2_N)
PF07662
(Nucleos_tra2_C)
PF07670
(Gate) 		3 LEU A  77
SER A  75
PHE A  76
 None
 0.63A 6fgcA-3tijA:
undetectable		 6fgcA-3tijA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tkk PREDICTED
ACETAMIDASE/FORMAMID
ASE

(Caldanaerobacter
subterraneus) 		PF03069
(FmdA_AmdA) 		3 LEU A 264
SER A 266
PHE A 265
 None
 0.66A 6fgcA-3tkkA:
undetectable		 6fgcA-3tkkA:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u7u RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4

(Homo sapiens) 		PF00757
(Furin-like)
PF01030
(Recep_L_domain)
PF14843
(GF_recep_IV) 		3 LEU A 395
SER A 393
PHE A 392
 None
 0.65A 6fgcA-3u7uA:
undetectable		 6fgcA-3u7uA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u7v BETA-GALACTOSIDASE

(Caulobacter
vibrioides) 		PF02449
(Glyco_hydro_42) 		3 LEU A 108
SER A 106
PHE A 105
 None
 0.64A 6fgcA-3u7vA:
undetectable		 6fgcA-3u7vA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vkg DYNEIN HEAVY CHAIN,
CYTOPLASMIC

(Dictyostelium
discoideum) 		PF03028
(Dynein_heavy)
PF07728
(AAA_5)
PF08393
(DHC_N2)
PF12774
(AAA_6)
PF12775
(AAA_7)
PF12777
(MT)
PF12780
(AAA_8)
PF12781
(AAA_9) 		3 LEU A4033
SER A4031
PHE A4030
 None
 0.61A 6fgcA-3vkgA:
undetectable		 6fgcA-3vkgA:
8.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vp5 TRANSCRIPTIONAL
REGULATOR

(Lactococcus
lactis) 		PF00440
(TetR_N) 		3 LEU A 155
SER A 157
PHE A 156
 None
 0.53A 6fgcA-3vp5A:
undetectable		 6fgcA-3vp5A:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wi3 DNA REPLICATION
REGULATOR SLD3

(Saccharomyces
cerevisiae) 		PF08639
(SLD3) 		3 LEU A 169
SER A 171
PHE A 170
 None
 0.64A 6fgcA-3wi3A:
undetectable		 6fgcA-3wi3A:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wy7 8-AMINO-7-OXONONANOA
TE SYNTHASE

(Mycolicibacterium
smegmatis) 		PF00155
(Aminotran_1_2) 		3 LEU A  93
SER A  91
PHE A  92
 None
 0.67A 6fgcA-3wy7A:
undetectable		 6fgcA-3wy7A:
23.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zef PRE-MRNA-SPLICING
FACTOR 8

(Saccharomyces
cerevisiae) 		PF08084
(PROCT)
PF10596
(U6-snRNA_bdg)
PF10597
(U5_2-snRNA_bdg)
PF10598
(RRM_4)
PF12134
(PRP8_domainIV) 		3 LEU B 890
SER B 894
PHE B 895
 None
 0.57A 6fgcA-3zefB:
undetectable		 6fgcA-3zefB:
16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a0h ADENOSYLMETHIONINE-8
-AMINO-7-OXONONANOAT
E AMINOTRANSFERASE

(Arabidopsis
thaliana) 		PF00202
(Aminotran_3)
PF13500
(AAA_26) 		3 LEU A  40
SER A  38
PHE A  39
 None
 0.66A 6fgcA-4a0hA:
undetectable		 6fgcA-4a0hA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aek ENDOGLUCANASE CEL5A

([Eubacterium]
cellulosolvens) 		no annotation 3 LEU A 140
SER A 138
PHE A 137
 None
 0.58A 6fgcA-4aekA:
undetectable		 6fgcA-4aekA:
14.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aov ISOCITRATE
DEHYDROGENASE [NADP]

(Desulfotalea
psychrophila) 		PF00180
(Iso_dh) 		3 LEU A 384
SER A 386
PHE A 389
 None
 0.56A 6fgcA-4aovA:
5.5		 6fgcA-4aovA:
23.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4av6 K(+)-STIMULATED
PYROPHOSPHATE-ENERGI
ZED SODIUM PUMP

(Thermotoga
maritima) 		PF03030
(H_PPase) 		3 LEU A  50
SER A  48
PHE A  49
 None
 0.66A 6fgcA-4av6A:
undetectable		 6fgcA-4av6A:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ayr MANNOSYL-OLIGOSACCHA
RIDE
1,2-ALPHA-MANNOSIDAS
E

(Caulobacter sp.
K31) 		PF01532
(Glyco_hydro_47) 		3 LEU A  80
SER A  70
PHE A  71
 None
 0.57A 6fgcA-4ayrA:
undetectable		 6fgcA-4ayrA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bl3 PENICILLIN BINDING
PROTEIN 2 PRIME

(Staphylococcus
aureus) 		PF00905
(Transpeptidase)
PF03717
(PBP_dimer)
PF05223
(MecA_N) 		3 LEU A 474
SER A 476
PHE A 479
 None
 0.55A 6fgcA-4bl3A:
undetectable		 6fgcA-4bl3A:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cvu BETA-MANNOSIDASE

(Trichoderma
harzianum) 		PF00703
(Glyco_hydro_2) 		3 LEU A 226
SER A 228
PHE A 260
 None
 0.58A 6fgcA-4cvuA:
undetectable		 6fgcA-4cvuA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eaa PEROSAMINE
N-ACETYLTRANSFERASE

(Caulobacter
vibrioides) 		PF00132
(Hexapep) 		3 LEU A  69
SER A  92
PHE A  91
 None
 0.67A 6fgcA-4eaaA:
undetectable		 6fgcA-4eaaA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f4c MULTIDRUG RESISTANCE
PROTEIN PGP-1

(Caenorhabditis
elegans) 		PF00005
(ABC_tran)
PF00664
(ABC_membrane) 		3 LEU A 813
SER A 811
PHE A 812
 None
 0.65A 6fgcA-4f4cA:
undetectable		 6fgcA-4f4cA:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f6o METACASPASE-1

(Saccharomyces
cerevisiae) 		PF00656
(Peptidase_C14) 		3 LEU A 359
SER A 382
PHE A 385
 None
 0.60A 6fgcA-4f6oA:
4.0		 6fgcA-4f6oA:
21.73