SIMILAR PATTERNS OF AMINO ACIDS FOR 6FDY_U_DB8U302_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f3l PROTEIN ARGININE
METHYLTRANSFERASE
PRMT3

(Rattus
norvegicus) 		PF06325
(PrmA) 		5 LEU A 512
VAL A 502
SER A 363
LEU A 364
ILE A 500
 None
 1.17A 6fdyU-1f3lA:
0.0		 6fdyU-1f3lA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gud D-ALLOSE-BINDING
PERIPLASMIC PROTEIN

(Escherichia
coli) 		PF13407
(Peripla_BP_4) 		5 LEU A  90
MET A  19
VAL A   6
LEU A  11
ILE A  36
 None
 1.39A 6fdyU-1gudA:
0.0		 6fdyU-1gudA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jmu PROTEIN MU-1

(Reovirus sp.) 		PF05993
(Reovirus_M2) 		5 LEU A  34
SER B 134
LEU B 118
GLU B 115
ILE B 178
 None
 1.32A 6fdyU-1jmuA:
undetectable		 6fdyU-1jmuA:
8.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nhw ENOYL-ACYL CARRIER
REDUCTASE

(Plasmodium
falciparum) 		PF13561
(adh_short_C2) 		5 VAL C 413
PHE C 397
SER C 396
LEU C 398
ILE A 310
 None
 0.87A 6fdyU-1nhwC:
undetectable		 6fdyU-1nhwC:
13.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qpo QUINOLINATE ACID
PHOSPHORIBOSYL
TRANSFERASE

(Mycobacterium
tuberculosis) 		PF01729
(QRPTase_C)
PF02749
(QRPTase_N) 		5 LEU A 186
VAL A 200
SER A 204
LEU A 208
ILE A 219
 None
 1.36A 6fdyU-1qpoA:
0.0		 6fdyU-1qpoA:
25.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u9c APC35852

(Geobacillus
stearothermophilus) 		PF01965
(DJ-1_PfpI) 		5 LEU A 197
PRO A 129
VAL A 144
SER A 172
LEU A 170
 None
 1.36A 6fdyU-1u9cA:
0.0		 6fdyU-1u9cA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vkm CONSERVED
HYPOTHETICAL PROTEIN
TM1464

(Thermotoga
maritima) 		PF04227
(Indigoidine_A) 		5 LEU A 237
PRO A 122
VAL A 244
SER A 148
LEU A 150
 None
 1.36A 6fdyU-1vkmA:
0.0		 6fdyU-1vkmA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w66 LIPOYLTRANSFERASE

(Mycobacterium
tuberculosis) 		PF03099
(BPL_LplA_LipB) 		5 LEU A  46
PRO A  92
VAL A  14
LEU A 211
ILE A  12
 None
 1.25A 6fdyU-1w66A:
0.8		 6fdyU-1w66A:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wpw 3-ISOPROPYLMALATE
DEHYDROGENASE

(Sulfurisphaera
tokodaii) 		PF00180
(Iso_dh) 		5 LEU A 314
PRO A 270
VAL A 307
LEU A 274
ILE A 331
 None
 1.32A 6fdyU-1wpwA:
0.0		 6fdyU-1wpwA:
23.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z8l GLUTAMATE
CARBOXYPEPTIDASE II

(Homo sapiens) 		PF02225
(PA)
PF04253
(TFR_dimer)
PF04389
(Peptidase_M28) 		5 LEU A 462
PRO A 510
VAL A 464
SER A 472
ILE A 512
 None
None
None
NAG  A1758 (-3.0A)
None
 0.98A 6fdyU-1z8lA:
undetectable		 6fdyU-1z8lA:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2arc ARABINOSE OPERON
REGULATORY PROTEIN

(Escherichia
coli) 		PF02311
(AraC_binding) 		5 VAL A  96
PHE A 130
SER A 131
LEU A 133
ILE A 137
 None
 0.74A 6fdyU-2arcA:
undetectable		 6fdyU-2arcA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2awf UBIQUITIN-CONJUGATIN
G ENZYME E2 G1

(Homo sapiens) 		PF00179
(UQ_con) 		5 LEU A  59
VAL A  40
SER A 126
LEU A 128
ILE A  42
 None
 1.32A 6fdyU-2awfA:
undetectable		 6fdyU-2awfA:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bf6 EXO-ALPHA-SIALIDASE

(Clostridium
perfringens) 		PF13088
(BNR_2) 		5 VAL A 599
SER A 690
LEU A 688
GLU A 689
ILE A 622
 None
 1.25A 6fdyU-2bf6A:
0.7		 6fdyU-2bf6A:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2db3 ATP-DEPENDENT RNA
HELICASE VASA

(Drosophila
melanogaster) 		PF00270
(DEAD)
PF00271
(Helicase_C) 		5 VAL A 496
PHE A 508
SER A 507
LEU A 509
ILE A 544
 None
 0.72A 6fdyU-2db3A:
undetectable		 6fdyU-2db3A:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dme PHD FINGER PROTEIN 3

(Homo sapiens) 		PF07500
(TFIIS_M) 		5 PHE A  54
SER A  53
LEU A  51
GLU A  50
ILE A  47
 None
 0.91A 6fdyU-2dmeA:
undetectable		 6fdyU-2dmeA:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eje GENERAL
TRANSCRIPTION FACTOR
II-I

(Homo sapiens) 		PF02946
(GTF2I) 		5 MET A  63
VAL A  60
SER A  31
LEU A  29
ILE A  90
 None
 1.39A 6fdyU-2ejeA:
undetectable		 6fdyU-2ejeA:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ft3 BIGLYCAN

(Bos taurus) 		PF01462
(LRRNT)
PF13855
(LRR_8) 		5 LEU A 213
PRO A 188
SER A 180
LEU A 184
ILE A 205
 None
 1.00A 6fdyU-2ft3A:
undetectable		 6fdyU-2ft3A:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hdn ELONGATION FACTOR
EF-TU

(Escherichia
coli) 		PF00009
(GTP_EFTU)
PF03143
(GTP_EFTU_D3)
PF03144
(GTP_EFTU_D2) 		5 LEU B 134
PRO B 111
VAL B 132
SER B 158
LEU B 156
 None
 1.33A 6fdyU-2hdnB:
undetectable		 6fdyU-2hdnB:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i6e HYPOTHETICAL PROTEIN

(Deinococcus
radiodurans) 		PF02621
(VitK2_biosynth) 		5 VAL A 165
SER A 142
LEU A 144
GLU A 141
ILE A 185
 None
 1.00A 6fdyU-2i6eA:
undetectable		 6fdyU-2i6eA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jjp CYTOCHROME P450
113A1

(Saccharopolyspora
erythraea) 		PF00067
(p450) 		5 VAL A 365
SER A 112
LEU A 114
GLU A 115
ILE A 118
 None
 1.42A 6fdyU-2jjpA:
undetectable		 6fdyU-2jjpA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2k24 PUTATIVE
UNCHARACTERIZED
PROTEIN TA0956

(Thermoplasma
acidophilum) 		PF11513
(TA0956) 		5 PHE A  30
SER A  29
LEU A  33
GLU A  32
ILE A  36
 None
 1.36A 6fdyU-2k24A:
undetectable		 6fdyU-2k24A:
15.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2l4b ACYL CARRIER PROTEIN

(Anaplasma
phagocytophilum) 		PF00550
(PP-binding) 		5 PHE A  59
SER A  60
LEU A  61
GLU A  56
ILE A  63
 None
 1.13A 6fdyU-2l4bA:
undetectable		 6fdyU-2l4bA:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o55 PUTATIVE
GLYCEROPHOSPHODIESTE
R PHOSPHODIESTERASE

(Galdieria
sulphuraria) 		PF03009
(GDPD) 		5 LEU A 238
VAL A 219
PHE A 254
LEU A 251
ILE A 243
 None
 1.40A 6fdyU-2o55A:
undetectable		 6fdyU-2o55A:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2okc TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN

(Bacteroides
thetaiotaomicron) 		PF02384
(N6_Mtase)
PF12161
(HsdM_N) 		6 LEU A 306
VAL A 304
PHE A 328
SER A 354
LEU A 296
ILE A 256
 None
 1.49A 6fdyU-2okcA:
undetectable		 6fdyU-2okcA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qhx PTERIDINE REDUCTASE
1

(Leishmania
major) 		PF00106
(adh_short)
PF13561
(adh_short_C2) 		5 MET A 179
VAL A 107
SER A 266
LEU A 264
ILE A 177
 None
 1.40A 6fdyU-2qhxA:
undetectable		 6fdyU-2qhxA:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ri0 GLUCOSAMINE-6-PHOSPH
ATE DEAMINASE

(Streptococcus
mutans) 		PF01182
(Glucosamine_iso) 		5 PRO A 211
VAL A 206
SER A 141
LEU A 176
ILE A 214
 None
 1.11A 6fdyU-2ri0A:
undetectable		 6fdyU-2ri0A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wgp DUAL SPECIFICITY
PROTEIN PHOSPHATASE
14

(Homo sapiens) 		PF00782
(DSPc) 		5 LEU A  36
VAL A 141
PHE A 154
LEU A 158
ILE A 123
 None
 1.35A 6fdyU-2wgpA:
undetectable		 6fdyU-2wgpA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a79 TOLL-LIKE RECEPTOR
6, VARIABLE
LYMPHOCYTE RECEPTOR
B

(Eptatretus
burgeri;
Mus musculus) 		PF11921
(DUF3439)
PF13855
(LRR_8) 		5 LEU B 496
VAL B 469
SER B 487
LEU B 485
ILE B 465
 None
 1.27A 6fdyU-3a79B:
undetectable		 6fdyU-3a79B:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3am3 ENOYL-ACP REDUCTASE

(Plasmodium
falciparum) 		PF13561
(adh_short_C2) 		5 VAL A 413
PHE A 397
SER A 396
LEU A 398
ILE A 310
 None
 0.88A 6fdyU-3am3A:
undetectable		 6fdyU-3am3A:
24.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b5n PROTEIN SSO1
PROTEIN TRANSPORT
PROTEIN SEC9
SYNAPTOBREVIN
HOMOLOG 1

(Saccharomyces
cerevisiae) 		PF00804
(Syntaxin)
PF00957
(Synaptobrevin)
PF05739
(SNARE)
no annotation 		5 LEU D 619
VAL A  50
PHE B 214
LEU B 213
ILE A  47
 None
 1.10A 6fdyU-3b5nD:
undetectable		 6fdyU-3b5nD:
13.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dv8 TRANSCRIPTIONAL
REGULATOR, CRP/FNR
FAMILY

([Eubacterium]
rectale) 		PF00027
(cNMP_binding)
PF13545
(HTH_Crp_2) 		5 LEU A 200
VAL A 198
PHE A 154
SER A 153
ILE A 207
 None
 1.05A 6fdyU-3dv8A:
undetectable		 6fdyU-3dv8A:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f4b ENOYL-ACYL CARRIER
PROTEIN REDUCTASE

(Plasmodium
berghei) 		PF13561
(adh_short_C2) 		5 VAL A 377
PHE A 361
SER A 360
LEU A 362
ILE A 295
 None
 0.87A 6fdyU-3f4bA:
undetectable		 6fdyU-3f4bA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fu1 GENERAL SECRETION
PATHWAY PROTEIN G

(Vibrio cholerae) 		PF08334
(T2SSG) 		5 LEU A  64
PRO A  58
VAL A 110
GLU A  44
ILE A 108
 None
None
None
ZN  A 201 (-3.0A)
None
 1.40A 6fdyU-3fu1A:
undetectable		 6fdyU-3fu1A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h0x 78 KDA
GLUCOSE-REGULATED
PROTEIN HOMOLOG

(Saccharomyces
cerevisiae) 		PF00012
(HSP70) 		5 PRO A 455
MET A 453
VAL A 485
SER A 468
ILE A 446
 None
 1.37A 6fdyU-3h0xA:
undetectable		 6fdyU-3h0xA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hi8 PROLIFERATING CELL
NUCLEAR ANTIGEN PCNA

(Haloferax
volcanii) 		PF00705
(PCNA_N)
PF02747
(PCNA_C) 		5 LEU A  73
VAL A  68
SER A  35
LEU A  29
ILE A  66
 None
 1.41A 6fdyU-3hi8A:
undetectable		 6fdyU-3hi8A:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ho6 TOXIN A

(Clostridioides
difficile) 		PF11713
(Peptidase_C80) 		5 LEU A 155
PHE A 138
SER A 137
LEU A 139
ILE A 179
 None
 0.88A 6fdyU-3ho6A:
undetectable		 6fdyU-3ho6A:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mmp ELONGATION FACTOR TU
2, ELONGATION FACTOR
TS

(Escherichia
coli) 		PF00009
(GTP_EFTU)
PF00889
(EF_TS)
PF03143
(GTP_EFTU_D3)
PF03144
(GTP_EFTU_D2) 		5 LEU A1134
PRO A1111
VAL A1132
SER A1158
LEU A1156
 None
 1.31A 6fdyU-3mmpA:
undetectable		 6fdyU-3mmpA:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mq2 16S RRNA
METHYLTRANSFERASE

(Streptoalloteichus
tenebrarius) 		PF02390
(Methyltransf_4) 		5 LEU A 189
PHE A 133
SER A 132
LEU A  99
GLU A  98
 None
 1.39A 6fdyU-3mq2A:
undetectable		 6fdyU-3mq2A:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mv3 COATOMER SUBUNIT
ALPHA

(Saccharomyces
cerevisiae) 		PF06957
(COPI_C) 		5 LEU A 987
VAL A1025
LEU A1197
GLU A1031
ILE A1199
 None
 1.32A 6fdyU-3mv3A:
undetectable		 6fdyU-3mv3A:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n26 AMINO ACID ABC
TRANSPORTER,
PERIPLASMIC AMINO
ACID-BINDING PROTEIN

(Chlamydia
pneumoniae) 		PF00497
(SBP_bac_3) 		5 LEU A  86
VAL A 220
LEU A  68
GLU A 227
ILE A 231
 None
 1.34A 6fdyU-3n26A:
undetectable		 6fdyU-3n26A:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nbi RECQ-MEDIATED GENOME
INSTABILITY PROTEIN
1

(Homo sapiens) 		PF08585
(RMI1_N) 		5 LEU A 157
VAL A 187
SER A 174
LEU A 180
ILE A 169
 None
 1.29A 6fdyU-3nbiA:
0.5		 6fdyU-3nbiA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oa7 HEAD MORPHOGENESIS
PROTEIN, CHAOTIC
NUCLEAR MIGRATION
PROTEIN 67 FUSION
PROTEIN

(Bacillus virus
phi29;
Saccharomyces
cerevisiae) 		PF11418
(Scaffolding_pro)
PF11778
(SID) 		5 LEU A 473
VAL A 475
SER A 461
LEU A 459
ILE A 455
 None
 1.28A 6fdyU-3oa7A:
undetectable		 6fdyU-3oa7A:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3opb SWI5-DEPENDENT HO
EXPRESSION PROTEIN 4

(Saccharomyces
cerevisiae) 		PF11701
(UNC45-central) 		5 MET A 396
PHE A 456
SER A 455
LEU A 457
ILE A 475
 None
 1.15A 6fdyU-3opbA:
undetectable		 6fdyU-3opbA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pko GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE

(Lactobacillus
brevis) 		PF00348
(polyprenyl_synt) 		5 LEU A 259
MET A 265
VAL A 273
LEU A 232
ILE A 270
 None
 1.17A 6fdyU-3pkoA:
undetectable		 6fdyU-3pkoA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s7v MAJOR CAPSID PROTEIN
VP1

(Human
polyomavirus 3) 		PF00718
(Polyoma_coat) 		5 LEU A 255
VAL A 164
PHE A 292
LEU A  52
ILE A 272
 None
 1.27A 6fdyU-3s7vA:
undetectable		 6fdyU-3s7vA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tjz ADP-RIBOSYLATION
FACTOR 1

(Saccharomyces
cerevisiae) 		PF00025
(Arf) 		5 LEU A  34
MET A  22
SER A 174
LEU A 173
ILE A  20
 None
 1.16A 6fdyU-3tjzA:
undetectable		 6fdyU-3tjzA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tjz ADP-RIBOSYLATION
FACTOR 1

(Saccharomyces
cerevisiae) 		PF00025
(Arf) 		5 LEU A  34
MET A  22
VAL A  65
SER A 174
LEU A 173
 None
 1.26A 6fdyU-3tjzA:
undetectable		 6fdyU-3tjzA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ckb MRNA-CAPPING ENZYME
CATALYTIC SUBUNIT

(Vaccinia virus) 		PF03291
(Pox_MCEL)
PF10640
(Pox_ATPase-GT) 		5 LEU A 252
VAL A 362
PHE A 391
LEU A 242
ILE A 247
 None
 1.37A 6fdyU-4ckbA:
undetectable		 6fdyU-4ckbA:
15.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ecn LEUCINE-RICH REPEAT
PROTEIN

(Bacteroides
thetaiotaomicron) 		PF14660
(DUF4458) 		5 LEU A 720
PHE A 654
SER A 655
LEU A 659
ILE A 684
 None
 1.09A 6fdyU-4ecnA:
undetectable		 6fdyU-4ecnA:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ecn LEUCINE-RICH REPEAT
PROTEIN

(Bacteroides
thetaiotaomicron) 		PF14660
(DUF4458) 		5 PRO A 663
PHE A 654
SER A 655
LEU A 659
ILE A 684
 None
 1.10A 6fdyU-4ecnA:
undetectable		 6fdyU-4ecnA:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eze HALOACID
DEHALOGENASE-LIKE
HYDROLASE

(Salmonella
enterica) 		PF12710
(HAD) 		5 PRO A 145
VAL A 152
LEU A 110
GLU A 109
ILE A 106
 None
 1.35A 6fdyU-4ezeA:
undetectable		 6fdyU-4ezeA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f32 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2

(Burkholderia
vietnamiensis) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		5 LEU A  27
PRO A  15
LEU A 350
GLU A 358
ILE A 357
 None
 1.30A 6fdyU-4f32A:
undetectable		 6fdyU-4f32A:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fwt ELONGATION FACTOR
TS, ELONGATION
FACTOR TU, LINKER, Q
BETA REPLICASE

(Escherichia
coli;
Escherichia
virus Qbeta) 		PF00009
(GTP_EFTU)
PF00889
(EF_TS)
PF03143
(GTP_EFTU_D3)
PF03144
(GTP_EFTU_D2)
PF03431
(RNA_replicase_B) 		5 LEU A 419
PRO A 396
VAL A 417
SER A 443
LEU A 441
 None
 1.18A 6fdyU-4fwtA:
undetectable		 6fdyU-4fwtA:
12.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g10 GLUTATHIONE
S-TRANSFERASE
HOMOLOG

(Sphingomonas
paucimobilis) 		PF13417
(GST_N_3)
PF16865
(GST_C_5) 		5 LEU A  25
VAL A  21
SER A  67
LEU A  68
ILE A  74
 None
 1.34A 6fdyU-4g10A:
undetectable		 6fdyU-4g10A:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hxq ARGINASE-1

(Homo sapiens) 		PF00491
(Arginase) 		5 LEU A 118
VAL A 120
SER A 146
LEU A 149
ILE A 174
 None
 1.29A 6fdyU-4hxqA:
undetectable		 6fdyU-4hxqA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ixu ARGINASE-2,
MITOCHONDRIAL

(Homo sapiens) 		PF00491
(Arginase) 		5 LEU A 137
VAL A 139
SER A 165
LEU A 168
ILE A 193
 None
 1.25A 6fdyU-4ixuA:
undetectable		 6fdyU-4ixuA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j0q ELONGATION FACTOR
TU-A

(Pseudomonas
putida) 		PF00009
(GTP_EFTU)
PF03143
(GTP_EFTU_D3)
PF03144
(GTP_EFTU_D2) 		5 LEU A 135
PRO A 112
VAL A 133
SER A 159
LEU A 157
 None
 1.39A 6fdyU-4j0qA:
undetectable		 6fdyU-4j0qA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lqk PROTEIN A46

(Vaccinia virus) 		no annotation 5 LEU C 116
SER C 195
LEU C 197
GLU C 196
ILE C 192
 None
 1.32A 6fdyU-4lqkC:
undetectable		 6fdyU-4lqkC:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m4d LIPOPOLYSACCHARIDE-B
INDING PROTEIN

(Mus musculus) 		PF01273
(LBP_BPI_CETP)
PF02886
(LBP_BPI_CETP_C) 		5 LEU A 178
VAL A 168
SER A 187
LEU A 189
GLU A 186
 None
 1.41A 6fdyU-4m4dA:
2.4		 6fdyU-4m4dA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mn5 SENSOR PROTEIN
KINASE WALK

(Staphylococcus
aureus) 		PF13426
(PAS_9) 		5 LEU A 293
VAL A 288
SER A 310
LEU A 312
ILE A 277
 None
 1.04A 6fdyU-4mn5A:
undetectable		 6fdyU-4mn5A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mn6 SENSOR PROTEIN
KINASE WALK

(Staphylococcus
aureus) 		PF13426
(PAS_9) 		5 LEU A 293
VAL A 288
SER A 310
LEU A 312
ILE A 277
 None
 1.01A 6fdyU-4mn6A:
undetectable		 6fdyU-4mn6A:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mx8 PERIPLASMIC BINDING
PROTEIN

(Xylanimonas
cellulosilytica) 		PF01497
(Peripla_BP_2) 		5 LEU A 209
MET A 303
VAL A 213
LEU A 163
ILE A 167
 None
 1.20A 6fdyU-4mx8A:
undetectable		 6fdyU-4mx8A:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nmw PIMELYL-[ACYL-CARRIE
R PROTEIN] METHYL
ESTER ESTERASE

(Salmonella
enterica) 		PF00561
(Abhydrolase_1) 		5 PRO A 198
VAL A 103
SER A 254
LEU A 256
ILE A  77
 None
 1.24A 6fdyU-4nmwA:
undetectable		 6fdyU-4nmwA:
24.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pl2 DUAL-SPECIFICITY RNA
METHYLTRANSFERASE
RLMN

(Escherichia
coli) 		no annotation 5 LEU B 265
VAL B 275
SER B 213
LEU B 234
ILE B 277
 None
None
SF4  B 401 (-3.1A)
None
None
 1.36A 6fdyU-4pl2B:
undetectable		 6fdyU-4pl2B:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pn0 MRNA-CAPPING ENZYME
SUBUNIT BETA

(Schizosaccharomyces
pombe) 		PF02940
(mRNA_triPase) 		5 LEU A 284
VAL A 288
SER A 205
LEU A 191
ILE A  61
 None
 1.30A 6fdyU-4pn0A:
undetectable		 6fdyU-4pn0A:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ql0 FILAMENTOUS
HEMAGGLUTININ
TRANSPORTER PROTEIN
FHAC

(Bordetella
pertussis) 		PF03865
(ShlB)
PF08479
(POTRA_2)
PF17287
(POTRA_3) 		5 LEU A 496
VAL A 443
PHE A 428
SER A 406
LEU A 426
 None
 1.41A 6fdyU-4ql0A:
1.0		 6fdyU-4ql0A:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r04 TOXIN A

(Clostridioides
difficile) 		PF11713
(Peptidase_C80)
PF12918
(TcdB_N)
PF12919
(TcdA_TcdB)
PF12920
(TcdA_TcdB_pore) 		5 LEU A 697
PHE A 680
SER A 679
LEU A 681
ILE A 721
 None
 1.06A 6fdyU-4r04A:
1.2		 6fdyU-4r04A:
8.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r9g MBP1

(Caldanaerobius
polysaccharolyticus) 		PF13416
(SBP_bac_8) 		5 LEU A 225
VAL A 200
SER A 269
LEU A 141
ILE A 291
 None
 1.28A 6fdyU-4r9gA:
undetectable		 6fdyU-4r9gA:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4s12 N-ACETYLMURAMIC ACID
6-PHOSPHATE ETHERASE

(Yersinia
enterocolitica) 		PF01380
(SIS) 		5 LEU A 257
PRO A 266
VAL A 242
LEU A 291
ILE A 268
 None
 1.38A 6fdyU-4s12A:
undetectable		 6fdyU-4s12A:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uwa RYANODINE RECEPTOR 1

(Oryctolagus
cuniculus) 		PF00622
(SPRY)
PF01365
(RYDR_ITPR)
PF02026
(RyR)
PF02815
(MIR)
PF08709
(Ins145_P3_rec) 		5 LEU A2927
MET A2816
VAL A2937
LEU A2751
ILE A2823
 None
 1.37A 6fdyU-4uwaA:
undetectable		 6fdyU-4uwaA:
5.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y1p 3-ISOPROPYLMALATE
DEHYDROGENASE

(Sulfolobus
acidocaldarius) 		PF00180
(Iso_dh) 		5 LEU A 315
MET A 328
VAL A 308
LEU A 275
ILE A 332
 None
 1.03A 6fdyU-4y1pA:
undetectable		 6fdyU-4y1pA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yei BETA1MUT

(synthetic
construct) 		PF00805
(Pentapeptide) 		5 LEU A  27
VAL A  23
SER A  68
LEU A  67
ILE A  45
 None
 1.20A 6fdyU-4yeiA:
undetectable		 6fdyU-4yeiA:
23.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z3l MAJOR POLLEN
ALLERGEN BET V 1-A

(Betula pendula) 		PF00407
(Bet_v_1) 		5 LEU A 114
SER A 149
LEU A 151
GLU A 148
ILE A  13
 None
 1.13A 6fdyU-4z3lA:
undetectable		 6fdyU-4z3lA:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zwj CHIMERA PROTEIN OF
HUMAN RHODOPSIN,
MOUSE S-ARRESTIN,
AND T4 ENDOLYSIN

(Escherichia
virus T4;
Homo sapiens;
Mus musculus) 		PF00001
(7tm_1)
PF00339
(Arrestin_N)
PF00959
(Phage_lysozyme)
PF02752
(Arrestin_C)
PF10413
(Rhodopsin_N) 		5 LEU A2279
PRO A2222
VAL A2240
SER A2190
ILE A2330
 None
 1.25A 6fdyU-4zwjA:
undetectable		 6fdyU-4zwjA:
14.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zwj CHIMERA PROTEIN OF
HUMAN RHODOPSIN,
MOUSE S-ARRESTIN,
AND T4 ENDOLYSIN

(Escherichia
virus T4;
Homo sapiens;
Mus musculus) 		PF00001
(7tm_1)
PF00339
(Arrestin_N)
PF00959
(Phage_lysozyme)
PF02752
(Arrestin_C)
PF10413
(Rhodopsin_N) 		5 PRO A2222
VAL A2240
SER A2190
LEU A2210
ILE A2330
 None
 1.32A 6fdyU-4zwjA:
undetectable		 6fdyU-4zwjA:
14.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b19 ASPARTATE RACEMASE

(Picrophilus
torridus) 		PF01177
(Asp_Glu_race) 		5 MET A  81
SER A  73
LEU A  71
GLU A  72
ILE A  79
 None
 1.39A 6fdyU-5b19A:
undetectable		 6fdyU-5b19A:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cyf PUTATIVE URIDINE
PHOSPHORYLASE

(Schistosoma
mansoni) 		PF01048
(PNP_UDP_1) 		5 LEU A 282
VAL A 252
PHE A  41
LEU A 118
ILE A 250
 None
 1.25A 6fdyU-5cyfA:
undetectable		 6fdyU-5cyfA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dx5 METHIONINE
GAMMA-LYASE

(Clostridium
sporogenes) 		PF01053
(Cys_Met_Meta_PP) 		5 LEU A 199
PRO A 193
VAL A 226
SER A 209
LEU A 214
 None
None
None
PLP  A 501 (-2.8A)
None
 1.37A 6fdyU-5dx5A:
undetectable		 6fdyU-5dx5A:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eaw DNA REPLICATION
ATP-DEPENDENT
HELICASE/NUCLEASE
DNA2

(Mus musculus) 		PF08696
(Dna2)
PF13086
(AAA_11)
PF13087
(AAA_12) 		5 LEU A 883
VAL A 886
SER A 982
LEU A 980
ILE A1014
 None
 1.39A 6fdyU-5eawA:
undetectable		 6fdyU-5eawA:
14.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g1n CAD PROTEIN

(Homo sapiens) 		PF00185
(OTCace)
PF02729
(OTCace_N) 		5 LEU A2067
MET A2073
VAL A2141
LEU A2094
ILE A2075
 None
 1.27A 6fdyU-5g1nA:
undetectable		 6fdyU-5g1nA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gvh ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[FMN]

(Thermotoga
maritima) 		PF03060
(NMO) 		5 LEU A  18
PRO A  16
PHE A 301
LEU A 298
ILE A 294
 None
 1.34A 6fdyU-5gvhA:
undetectable		 6fdyU-5gvhA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nt7 ATP-DEPENDENT RNA
HELICASE VASA,
ISOFORM A

(Drosophila
melanogaster) 		PF00271
(Helicase_C) 		5 VAL B 496
PHE B 508
SER B 507
LEU B 509
ILE B 544
 None
 0.92A 6fdyU-5nt7B:
undetectable		 6fdyU-5nt7B:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o60 50S RIBOSOMAL
PROTEIN L5

(Mycolicibacterium
smegmatis) 		PF00281
(Ribosomal_L5)
PF00673
(Ribosomal_L5_C) 		5 LEU F  64
MET F 159
VAL F  43
LEU F 110
ILE F 161
 None
 1.39A 6fdyU-5o60F:
undetectable		 6fdyU-5o60F:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t0h 26S PROTEASOME
NON-ATPASE
REGULATORY SUBUNIT 2

(Homo sapiens) 		PF00004
(AAA) 		5 LEU f 513
PHE f 554
SER f 552
LEU f 551
ILE f 547
 None
 1.04A 6fdyU-5t0hf:
undetectable		 6fdyU-5t0hf:
16.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w7q CONSENSUS ELONGATION
FACTOR

(synthetic
construct) 		no annotation 5 LEU A 135
PRO A 112
VAL A 133
SER A 159
LEU A 157
 None
 1.37A 6fdyU-5w7qA:
undetectable		 6fdyU-5w7qA:
13.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wix P-47 PROTEIN

(Clostridium
botulinum) 		no annotation 5 LEU A 289
MET A 227
PHE A 376
SER A 333
LEU A 378
 None
 1.32A 6fdyU-5wixA:
0.8		 6fdyU-5wixA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x2v L-METHIONINE
GAMMA-LYASE

(Pseudomonas
putida) 		PF01053
(Cys_Met_Meta_PP) 		5 LEU A 198
PRO A 192
VAL A 225
SER A 208
LEU A 213
 None
None
None
LLP  A 211 ( 2.7A)
None
 1.40A 6fdyU-5x2vA:
undetectable		 6fdyU-5x2vA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x87 BESTROPHIN

(Klebsiella
pneumoniae) 		no annotation 5 LEU A 250
PHE A  57
SER A  58
LEU A  60
ILE A  64
 None
 1.24A 6fdyU-5x87A:
undetectable		 6fdyU-5x87A:
25.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xfl CATENIN ALPHA-2

(Mus musculus) 		no annotation 5 LEU A 577
PHE A 509
SER A 511
GLU A 514
ILE A 517
 None
 1.16A 6fdyU-5xflA:
1.5		 6fdyU-5xflA:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y6n HELICASE DOMAIN FROM
GENOME POLYPROTEIN

(Zika virus) 		no annotation 5 PHE A 391
SER A 387
LEU A 386
GLU A 394
ILE A 384
 None
 1.31A 6fdyU-5y6nA:
undetectable		 6fdyU-5y6nA:
15.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ar3 GSI-IIC RT

(Geobacillus
stearothermophilus) 		no annotation 5 LEU A 165
VAL A 155
SER A 196
LEU A 198
ILE A 202
 None
 1.36A 6fdyU-6ar3A:
undetectable		 6fdyU-6ar3A:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6baa ATP-SENSITIVE INWARD
RECTIFIER POTASSIUM
CHANNEL 11

(Rattus
norvegicus) 		no annotation 5 LEU A 233
VAL A 220
SER A  37
GLU A 282
ILE A 284
 None
 1.41A 6fdyU-6baaA:
undetectable		 6fdyU-6baaA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cjb CYSTATHIONINE
BETA-LYASE

(Legionella
pneumophila) 		no annotation 5 LEU A 186
PRO A 180
VAL A 213
SER A 196
LEU A 201
 None
None
None
LLP  A 199 ( 2.7A)
None
 1.41A 6fdyU-6cjbA:
undetectable		 6fdyU-6cjbA:
13.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cjb CYSTATHIONINE
BETA-LYASE

(Legionella
pneumophila) 		no annotation 5 LEU A 186
VAL A 213
SER A 196
LEU A 201
ILE A  62
 None
None
LLP  A 199 ( 2.7A)
None
None
 1.17A 6fdyU-6cjbA:
undetectable		 6fdyU-6cjbA:
13.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cr0 (S)-6-HYDROXYNICOTIN
E OXIDASE

(Shinella sp.
HZN7) 		no annotation 5 LEU A 260
PRO A 230
VAL A  11
LEU A 245
ILE A  34
 FAD  A 507 (-4.3A)
FAD  A 507 (-4.6A)
FAD  A 507 (-4.8A)
None
None
 1.26A 6fdyU-6cr0A:
undetectable		 6fdyU-6cr0A:
17.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d47 BETA SLIDING CLAMP

(Mycobacterium
marinum) 		no annotation 5 LEU A 178
VAL A 176
SER A 227
LEU A 228
ILE A 171
 None
 1.15A 6fdyU-6d47A:
undetectable		 6fdyU-6d47A:
11.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fae ADP-RIBOSYLATION
FACTOR 1

(Homo sapiens) 		no annotation 5 LEU B  34
MET B  22
VAL B  65
SER B 174
ILE B  20
 None
 1.14A 6fdyU-6faeB:
undetectable		 6fdyU-6faeB:
12.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fae IQ MOTIF AND SEC7
DOMAIN-CONTAINING
PROTEIN 2

(Homo sapiens) 		no annotation 5 LEU A 696
PHE A 721
SER A 723
LEU A 725
ILE A 729
 None
 1.38A 6fdyU-6faeA:
undetectable		 6fdyU-6faeA:
14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gpc -

(-) 		no annotation 5 LEU A  11
VAL A  71
SER A 121
LEU A 123
ILE A 106
 None
 1.42A 6fdyU-6gpcA:
undetectable		 6fdyU-6gpcA:
undetectable