SIMILAR PATTERNS OF AMINO ACIDS FOR 6FBP_B_ADNB404_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c4k PROTEIN (ORNITHINE
DECARBOXYLASE)

(Lactobacillus
sp. 30A) 		PF01276
(OKR_DC_1)
PF03709
(OKR_DC_1_N)
PF03711
(OKR_DC_1_C) 		5 ASP A 370
ILE A 347
ILE A 313
HIS A 308
ASP A 344
 None
 1.36A 6fbpA-1c4kA:
undetectable
6fbpB-1c4kA:
undetectable		 6fbpA-1c4kA:
8.35
6fbpB-1c4kA:
8.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gtu GLUTATHIONE
S-TRANSFERASE

(Homo sapiens) 		PF02798
(GST_N)
PF14497
(GST_C_3) 		5 ASP A 156
ILE A 184
HIS A  14
PHE A 187
ASP A 161
 None
 1.38A 6fbpA-1gtuA:
undetectable
6fbpB-1gtuA:
undetectable		 6fbpA-1gtuA:
15.81
6fbpB-1gtuA:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ksi COPPER AMINE OXIDASE

(Pisum sativum) 		PF01179
(Cu_amine_oxid)
PF02727
(Cu_amine_oxidN2)
PF02728
(Cu_amine_oxidN3) 		5 ASP A  11
ASP A  45
LYS A 276
SER A 258
ASP A 250
 None
 1.49A 6fbpA-1ksiA:
undetectable
6fbpB-1ksiA:
undetectable		 6fbpA-1ksiA:
7.84
6fbpB-1ksiA:
7.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pd1 PROTEIN TRANSPORT
PROTEIN SEC24

(Saccharomyces
cerevisiae) 		PF00626
(Gelsolin)
PF04810
(zf-Sec23_Sec24)
PF04811
(Sec23_trunk)
PF04815
(Sec23_helical)
PF08033
(Sec23_BS) 		5 ASP A 215
ILE A 217
LYS A 546
SER A 549
ASP A 864
 None
 1.22A 6fbpA-1pd1A:
undetectable
6fbpB-1pd1A:
undetectable		 6fbpA-1pd1A:
7.73
6fbpB-1pd1A:
7.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t6p PHENYLALANINE
AMMONIA-LYASE

(Rhodotorula
toruloides) 		PF00221
(Lyase_aromatic) 		5 ASP A 396
ILE A 171
PRO A 217
SER A 175
ASP A 214
 None
None
None
None
175  A 211 ( 4.2A)
 1.45A 6fbpA-1t6pA:
undetectable
6fbpB-1t6pA:
undetectable		 6fbpA-1t6pA:
8.45
6fbpB-1t6pA:
8.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tff UBIQUITIN
THIOLESTERASE
PROTEIN OTUB2

(Homo sapiens) 		PF10275
(Peptidase_C65) 		5 ASP A  14
ILE A  15
ILE A  32
HIS A  22
ASP A  21
 None
 1.49A 6fbpA-1tffA:
undetectable
6fbpB-1tffA:
undetectable		 6fbpA-1tffA:
13.25
6fbpB-1tffA:
13.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1xrc S-ADENOSYLMETHIONINE
SYNTHETASE

(Escherichia
coli) 		PF00438
(S-AdoMet_synt_N)
PF02772
(S-AdoMet_synt_M)
PF02773
(S-AdoMet_synt_C) 		7 HIS A  14
PRO A  15
ASP A 163
LYS A 165
SER A 186
PHE A 230
ASP A 238
 None
 0.62A 6fbpA-1xrcA:
54.8
6fbpB-1xrcA:
52.9		 6fbpA-1xrcA:
43.36
6fbpB-1xrcA:
43.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zap SECRETED ASPARTIC
PROTEINASE

(Candida
albicans) 		PF00026
(Asp) 		5 ASP A  32
ILE A  30
ASP A 120
ILE A 119
SER A  88
 A70  A 500 ( 2.7A)
A70  A 500 (-4.3A)
None
A70  A 500 (-3.9A)
A70  A 500 ( 4.2A)
 1.21A 6fbpA-1zapA:
undetectable
6fbpB-1zapA:
undetectable		 6fbpA-1zapA:
13.21
6fbpB-1zapA:
13.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2auc MYOSIN A TAIL
INTERACTING PROTEIN

(Plasmodium
knowlesi) 		PF13405
(EF-hand_6) 		5 ASP A 111
ILE A 115
ILE A  93
SER A  97
ASP A 117
 None
 1.28A 6fbpA-2aucA:
undetectable
6fbpB-2aucA:
undetectable		 6fbpA-2aucA:
18.18
6fbpB-2aucA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bb0 IMIDAZOLONEPROPIONAS
E

(Bacillus
subtilis) 		PF01979
(Amidohydro_1) 		5 ILE A 248
ASP A 219
ILE A 220
SER A 232
ASP A 271
 None
 1.46A 6fbpA-2bb0A:
undetectable
6fbpB-2bb0A:
undetectable		 6fbpA-2bb0A:
12.18
6fbpB-2bb0A:
12.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d1g ACID PHOSPHATASE

(Francisella
tularensis) 		PF04185
(Phosphoesterase) 		5 ILE A 285
HIS A 106
PRO A 174
ASP A 387
ASP A 208
 None
VO4  A 801 (-3.8A)
VO4  A 801 (-4.1A)
UNX  A 601 ( 2.6A)
VO4  A 801 (-2.6A)
 1.44A 6fbpA-2d1gA:
undetectable
6fbpB-2d1gA:
undetectable		 6fbpA-2d1gA:
10.13
6fbpB-2d1gA:
10.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2obv S-ADENOSYLMETHIONINE
SYNTHETASE ISOFORM
TYPE-1

(Homo sapiens) 		PF00438
(S-AdoMet_synt_N)
PF02772
(S-AdoMet_synt_M)
PF02773
(S-AdoMet_synt_C) 		8 HIS A  29
PRO A  30
ASP A 179
LYS A 181
SER A 206
SER A 247
PHE A 250
ASP A 258
 SAM  A 501 (-3.6A)
SAM  A 501 (-4.2A)
SAM  A 501 (-2.7A)
SAM  A 501 (-3.9A)
SAM  A 501 ( 3.7A)
SAM  A 501 (-2.8A)
SAM  A 501 (-3.4A)
SAM  A 501 (-3.6A)
 0.24A 6fbpA-2obvA:
63.6
6fbpB-2obvA:
57.3		 6fbpA-2obvA:
82.61
6fbpB-2obvA:
82.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vr5 GLYCOGEN OPERON
PROTEIN GLGX

(Sulfolobus
solfataricus) 		PF00128
(Alpha-amylase)
PF02806
(Alpha-amylase_C)
PF02922
(CBM_48) 		5 ASP A  68
ILE A  69
HIS A 337
SER A  34
ASP A 308
 None
 1.26A 6fbpA-2vr5A:
undetectable
6fbpB-2vr5A:
undetectable		 6fbpA-2vr5A:
7.98
6fbpB-2vr5A:
7.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3flo DNA POLYMERASE ALPHA
SUBUNIT B

(Saccharomyces
cerevisiae) 		PF04042
(DNA_pol_E_B)
PF08418
(Pol_alpha_B_N) 		5 ILE A 436
ASP A 490
ILE A 492
PRO A 401
PHE A 469
 None
 1.33A 6fbpA-3floA:
undetectable
6fbpB-3floA:
undetectable		 6fbpA-3floA:
10.79
6fbpB-3floA:
10.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gg7 UNCHARACTERIZED
METALLOPROTEIN

(Deinococcus
radiodurans) 		PF01026
(TatD_DNase) 		5 ASP A 194
HIS A  58
PRO A  59
SER A 120
SER A 166
 MN  A 253 (-2.7A)
MRD  A 257 (-3.5A)
None
None
None
 1.47A 6fbpA-3gg7A:
undetectable
6fbpB-3gg7A:
undetectable		 6fbpA-3gg7A:
14.52
6fbpB-3gg7A:
14.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hq2 BACILLUS SUBTILIS
M32 CARBOXYPEPTIDASE

(Bacillus
subtilis) 		PF02074
(Peptidase_M32) 		5 ILE A 474
ILE A 293
HIS A 464
SER A 296
ASP A 476
 None
 1.36A 6fbpA-3hq2A:
undetectable
6fbpB-3hq2A:
undetectable		 6fbpA-3hq2A:
9.37
6fbpB-3hq2A:
9.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iml S-ADENOSYLMETHIONINE
SYNTHETASE

(Burkholderia
pseudomallei) 		PF00438
(S-AdoMet_synt_N)
PF02772
(S-AdoMet_synt_M)
PF02773
(S-AdoMet_synt_C) 		6 HIS A  16
PRO A  17
ASP A 167
LYS A 169
SER A 190
PHE A 234
 None
 0.20A 6fbpA-3imlA:
52.5
6fbpB-3imlA:
51.5		 6fbpA-3imlA:
10.78
6fbpB-3imlA:
10.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iml S-ADENOSYLMETHIONINE
SYNTHETASE

(Burkholderia
pseudomallei) 		PF00438
(S-AdoMet_synt_N)
PF02772
(S-AdoMet_synt_M)
PF02773
(S-AdoMet_synt_C) 		5 HIS A  16
PRO A  17
LYS A 169
SER A 190
ASP A 242
 None
 0.83A 6fbpA-3imlA:
52.5
6fbpB-3imlA:
51.5		 6fbpA-3imlA:
10.78
6fbpB-3imlA:
10.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jd5 28S RIBOSOMAL
PROTEIN S31,
MITOCHONDRIAL
28S RIBOSOMAL
PROTEIN S35,
MITOCHONDRIAL
PENTATRICOPEPTIDE
REPEAT
DOMAIN-CONTAINING
PROTEIN 3,
MITOCHONDRIAL

(Bos taurus;
Bos taurus;
Bos taurus) 		no annotation
PF00411
(Ribosomal_S11)
PF00312
(Ribosomal_S15) 		5 ILE h 306
HIS o 136
PRO o 135
SER k 164
SER k 160
 None
 1.41A 6fbpA-3jd5h:
undetectable
6fbpB-3jd5h:
undetectable		 6fbpA-3jd5h:
15.19
6fbpB-3jd5h:
15.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lp9 LS-24

(Lathyrus
sativus) 		PF00045
(Hemopexin) 		5 ASP A  69
ILE A  77
SER A  67
PHE A  10
ASP A  87
 NA  A 318 (-3.3A)
None
CL  A 314 (-3.9A)
None
None
 1.47A 6fbpA-3lp9A:
undetectable
6fbpB-3lp9A:
undetectable		 6fbpA-3lp9A:
15.45
6fbpB-3lp9A:
15.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rv2 S-ADENOSYLMETHIONINE
SYNTHASE

(Mycobacterium
marinum) 		PF00438
(S-AdoMet_synt_N)
PF02772
(S-AdoMet_synt_M)
PF02773
(S-AdoMet_synt_C) 		7 HIS A  17
PRO A  18
ASP A 179
LYS A 181
SER A 202
PHE A 251
ASP A 259
 None
None
None
None
None
None
CA  A 404 (-3.4A)
 0.70A 6fbpA-3rv2A:
50.6
6fbpB-3rv2A:
52.3		 6fbpA-3rv2A:
11.69
6fbpB-3rv2A:
11.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3so4 METHIONINE-ADENOSYLT
RANSFERASE

(Entamoeba
histolytica) 		PF00438
(S-AdoMet_synt_N)
PF02772
(S-AdoMet_synt_M)
PF02773
(S-AdoMet_synt_C) 		8 HIS A  16
PRO A  17
ASP A 166
LYS A 168
SER A 193
SER A 234
PHE A 237
ASP A 245
 None
None
None
ACT  A 400 ( 4.9A)
None
None
None
None
 0.65A 6fbpA-3so4A:
56.0
6fbpB-3so4A:
54.3		 6fbpA-3so4A:
46.73
6fbpB-3so4A:
46.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ss6 ACETYL-COA
ACETYLTRANSFERASE

(Bacillus
anthracis) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		5 ASP A 195
ILE A 198
PRO A 218
SER A 359
PHE A 194
 None
 1.45A 6fbpA-3ss6A:
undetectable
6fbpB-3ss6A:
undetectable		 6fbpA-3ss6A:
9.90
6fbpB-3ss6A:
9.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tat TYROSINE
AMINOTRANSFERASE

(Escherichia
coli) 		PF00155
(Aminotran_1_2) 		5 ASP A 222
ILE A 223
ILE A 259
SER A 255
ASP A 236
 PLP  A 500 (-3.7A)
None
None
PLP  A 500 ( 4.0A)
None
 1.44A 6fbpA-3tatA:
undetectable
6fbpB-3tatA:
undetectable		 6fbpA-3tatA:
13.01
6fbpB-3tatA:
13.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vys HYDROGENASE
EXPRESSION/FORMATION
PROTEIN HYPD

(Thermococcus
kodakarensis) 		PF01924
(HypD) 		5 ASP B  75
ILE B  76
ILE B 104
PRO B 317
ASP B 318
 None
 1.49A 6fbpA-3vysB:
undetectable
6fbpB-3vysB:
undetectable		 6fbpA-3vysB:
12.12
6fbpB-3vysB:
12.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4le5 S-ADENOSYLMETHIONINE
SYNTHETASE

(Campylobacter
jejuni) 		PF00438
(S-AdoMet_synt_N)
PF02772
(S-AdoMet_synt_M)
PF02773
(S-AdoMet_synt_C) 		6 HIS A  13
PRO A  14
ASP A 168
LYS A 170
SER A 197
ASP A 250
 None
 0.70A 6fbpA-4le5A:
49.7
6fbpB-4le5A:
46.9		 6fbpA-4le5A:
10.27
6fbpB-4le5A:
10.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4odj S-ADENOSYLMETHIONINE
SYNTHASE

(Cryptosporidium
hominis) 		PF00438
(S-AdoMet_synt_N)
PF02772
(S-AdoMet_synt_M)
PF02773
(S-AdoMet_synt_C) 		8 HIS A  34
PRO A  35
ASP A 187
LYS A 189
SER A 214
SER A 255
PHE A 258
ASP A 266
 SAM  A 500 ( 3.8A)
SAM  A 500 (-4.3A)
SAM  A 500 (-2.8A)
3PO  A 501 ( 2.7A)
SAM  A 500 ( 4.0A)
SAM  A 500 (-2.7A)
SAM  A 500 (-3.5A)
SAM  A 500 (-3.3A)
 0.31A 6fbpA-4odjA:
60.1
6fbpB-4odjA:
53.6		 6fbpA-4odjA:
12.32
6fbpB-4odjA:
12.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qg5 PUTATIVE
PHOSPHOGLUCOMUTASE

(Leishmania
major) 		PF00408
(PGM_PMM_IV)
PF02878
(PGM_PMM_I)
PF02879
(PGM_PMM_II)
PF02880
(PGM_PMM_III) 		5 ASP A 501
ILE A 500
PRO A 369
LYS A 373
SER A 381
 None
 1.42A 6fbpA-4qg5A:
undetectable
6fbpB-4qg5A:
undetectable		 6fbpA-4qg5A:
9.84
6fbpB-4qg5A:
9.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v06 TRYPTOPHAN
5-HYDROXYLASE 2

(Homo sapiens) 		PF00351
(Biopterin_H) 		5 ILE A 362
HIS A 318
PRO A 314
SER A 336
PHE A 296
 None
FE  A1491 ( 3.5A)
IMD  A 600 ( 4.7A)
None
IMD  A 600 (-4.7A)
 1.21A 6fbpA-4v06A:
undetectable
6fbpB-4v06A:
undetectable		 6fbpA-4v06A:
13.88
6fbpB-4v06A:
13.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5a1i S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2

(Homo sapiens) 		PF00438
(S-AdoMet_synt_N)
PF02772
(S-AdoMet_synt_M)
PF02773
(S-AdoMet_synt_C) 		8 HIS A  29
PRO A  30
ASP A 179
LYS A 181
SER A 206
SER A 247
PHE A 250
ASP A 258
 SAM  A 405 ( 3.6A)
SAM  A 405 (-4.0A)
ADN  A 407 (-2.8A)
PPK  A 400 ( 2.6A)
ADN  A 407 ( 3.9A)
ADN  A 407 (-2.7A)
SAM  A 405 (-3.4A)
K  A 403 ( 3.0A)
 0.19A 6fbpA-5a1iA:
63.4
6fbpB-5a1iA:
56.7		 6fbpA-5a1iA:
100.00
6fbpB-5a1iA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fql IDURONATE-2-SULFATAS
E

(Homo sapiens) 		PF00884
(Sulfatase) 		5 ILE A  43
ASP A  45
HIS A 138
PRO A 139
SER A  87
 None
CA  A1551 (-3.0A)
ALS  A  84 ( 3.7A)
None
ALS  A  84 ( 4.6A)
 1.49A 6fbpA-5fqlA:
undetectable
6fbpB-5fqlA:
undetectable		 6fbpA-5fqlA:
9.90
6fbpB-5fqlA:
9.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5h9u S-ADENOSYLMETHIONINE
SYNTHASE

(Thermus
thermophilus) 		no annotation 7 HIS C  16
PRO C  17
ASP C 175
SER C 198
SER C 240
PHE C 243
ASP C 251
 None
 0.80A 6fbpA-5h9uC:
55.5
6fbpB-5h9uC:
53.4		 6fbpA-5h9uC:
35.59
6fbpB-5h9uC:
35.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5h9u S-ADENOSYLMETHIONINE
SYNTHASE

(Thermus
thermophilus) 		no annotation 5 HIS C  16
PRO C  17
LYS C 177
SER C 198
ASP C 251
 None
 1.14A 6fbpA-5h9uC:
55.5
6fbpB-5h9uC:
53.4		 6fbpA-5h9uC:
35.59
6fbpB-5h9uC:
35.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hc4 LIPOLYTIC ENZYME

(uncultured
bacterium) 		PF07859
(Abhydrolase_3) 		5 ASP A   8
ILE A   5
ILE A  15
HIS A 317
ASP A 287
 None
None
None
TRS  A 402 (-4.3A)
None
 1.30A 6fbpA-5hc4A:
undetectable
6fbpB-5hc4A:
undetectable		 6fbpA-5hc4A:
13.33
6fbpB-5hc4A:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i67 PHOSPHOENOLPYRUVATE
CARBOXYKINASE [GTP]

(Mycobacterium
tuberculosis) 		PF00821
(PEPCK_C)
PF17297
(PEPCK_N) 		5 ASP A 296
ILE A 297
PRO A 467
LYS A 229
SER A 232
 MN  A 705 (-3.5A)
None
None
MN  A 705 (-3.1A)
None
 1.23A 6fbpA-5i67A:
undetectable
6fbpB-5i67A:
undetectable		 6fbpA-5i67A:
9.08
6fbpB-5i67A:
9.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jvk UNCHARACTERIZED
PROTEIN

(Bacteroides
cellulosilyticus) 		no annotation 5 ILE A 159
HIS A 137
SER A 188
PHE A 184
ASP A 162
 None
GOL  A 654 (-4.3A)
None
None
GOL  A 654 (-2.9A)
 1.11A 6fbpA-5jvkA:
undetectable
6fbpB-5jvkA:
undetectable		 6fbpA-5jvkA:
9.03
6fbpB-5jvkA:
9.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nec TONB-DEPENDENT
SIDEROPHORE RECEPTOR

(Pseudomonas
aeruginosa) 		no annotation 5 ASP A 437
ILE A 449
PRO A  49
SER A 133
PHE A 436
 None
 1.23A 6fbpA-5necA:
undetectable
6fbpB-5necA:
undetectable		 6fbpA-5necA:
23.08
6fbpB-5necA:
23.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5t8t S-ADENOSYLMETHIONINE
SYNTHASE

(Neisseria
gonorrhoeae) 		PF00438
(S-AdoMet_synt_N)
PF02772
(S-AdoMet_synt_M)
PF02773
(S-AdoMet_synt_C) 		5 HIS A  15
PRO A  16
ASP A 166
PHE A 235
ASP A 243
 None
 0.70A 6fbpA-5t8tA:
56.7
6fbpB-5t8tA:
51.8		 6fbpA-5t8tA:
41.07
6fbpB-5t8tA:
41.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5t8t S-ADENOSYLMETHIONINE
SYNTHASE

(Neisseria
gonorrhoeae) 		PF00438
(S-AdoMet_synt_N)
PF02772
(S-AdoMet_synt_M)
PF02773
(S-AdoMet_synt_C) 		5 HIS A  15
PRO A  16
ASP A 166
SER A 191
PHE A 235
 None
 0.41A 6fbpA-5t8tA:
56.7
6fbpB-5t8tA:
51.8		 6fbpA-5t8tA:
41.07
6fbpB-5t8tA:
41.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vgr ATLASTIN-3

(Homo sapiens) 		PF02263
(GBP)
PF02841
(GBP_C) 		5 ASP A  78
ILE A  76
ILE A 297
PRO A 268
PHE A  79
 None
None
None
GDP  A 501 (-4.0A)
None
 1.41A 6fbpA-5vgrA:
undetectable
6fbpB-5vgrA:
undetectable		 6fbpA-5vgrA:
13.28
6fbpB-5vgrA:
13.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xu6 INOSITOL-PENTAKISPHO
SPHATE 2-KINASE

(Cryptococcus
neoformans) 		PF06090
(Ins_P5_2-kin) 		5 ILE A 310
ILE A 394
PRO A 303
PHE A 295
ASP A 306
 None
 1.48A 6fbpA-5xu6A:
undetectable
6fbpB-5xu6A:
undetectable		 6fbpA-5xu6A:
11.08
6fbpB-5xu6A:
11.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yew MITOFUSIN-1,MITOFUSI
N-1 FUSION PROTEIN

(Homo sapiens) 		no annotation 5 ASP B 189
ILE B 192
SER B 179
PHE B  81
ASP B 183
 None
 1.33A 6fbpA-5yewB:
undetectable
6fbpB-5yewB:
undetectable		 6fbpA-5yewB:
22.62
6fbpB-5yewB:
22.62