SIMILAR PATTERNS OF AMINO ACIDS FOR 6FBN_B_SAMB401

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cvm PHYTASE

(Bacillus
amyloliquefaciens) 		PF02333
(Phytase) 		4 ALA A 174
ASP A 115
ILE A 116
ILE A 144
 None
 0.78A 6fbnA-1cvmA:
undetectable		 6fbnA-1cvmA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e6v METHYL-COENZYME M
REDUCTASE I BETA
SUBUNIT

(Methanopyrus
kandleri) 		PF02241
(MCR_beta)
PF02783
(MCR_beta_N) 		4 ALA B 160
ASP B  78
ILE B  79
ILE B  86
 None
 0.82A 6fbnA-1e6vB:
0.0		 6fbnA-1e6vB:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g2p ADENINE
PHOSPHORIBOSYLTRANSF
ERASE 1

(Saccharomyces
cerevisiae) 		PF00156
(Pribosyltran) 		4 ALA A  54
ASP A  61
ILE A  60
ILE A  63
 None
 0.87A 6fbnA-1g2pA:
undetectable		 6fbnA-1g2pA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ixp PYRIDOXINE
5'-PHOSPHATE
SYNTHASE

(Escherichia
coli) 		PF03740
(PdxJ) 		4 ALA A 149
ASP A 137
ILE A 134
ILE A 154
 None
 0.87A 6fbnA-1ixpA:
undetectable		 6fbnA-1ixpA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nbw GLYCEROL DEHYDRATASE
REACTIVASE ALPHA
SUBUNIT

(Klebsiella
pneumoniae) 		PF08841
(DDR) 		4 ALA A 581
ASP A 550
ILE A 551
ILE A 425
 None
 0.84A 6fbnA-1nbwA:
undetectable		 6fbnA-1nbwA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nl3 PREPROTEIN
TRANSLOCASE SECA 1
SUBUNIT

(Mycobacterium
tuberculosis) 		PF01043
(SecA_PP_bind)
PF07516
(SecA_SW)
PF07517
(SecA_DEAD) 		4 ALA A 369
ASP A 138
ILE A 127
ILE A 173
 None
 0.79A 6fbnA-1nl3A:
undetectable		 6fbnA-1nl3A:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p0c NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE

(Pelophylax
perezi) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 ALA A1014
ILE A1353
ASP A1049
ILE A1045
 None
 0.77A 6fbnA-1p0cA:
undetectable		 6fbnA-1p0cA:
23.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tki TITIN

(Homo sapiens) 		PF00069
(Pkinase) 		4 ALA A 269
ASP A 144
ILE A 145
ILE A 150
 None
 0.79A 6fbnA-1tkiA:
undetectable		 6fbnA-1tkiA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tsj CONSERVED
HYPOTHETICAL PROTEIN

(Staphylococcus
aureus) 		PF06983
(3-dmu-9_3-mt) 		4 ALA A 130
ASP A   2
ILE A   3
ILE A  53
 None
 0.84A 6fbnA-1tsjA:
undetectable		 6fbnA-1tsjA:
16.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tz7 4-ALPHA-GLUCANOTRANS
FERASE

(Aquifex
aeolicus) 		PF02446
(Glyco_hydro_77) 		4 GLU A 420
ASP A 439
ILE A 422
ILE A 474
 None
 0.84A 6fbnA-1tz7A:
undetectable		 6fbnA-1tz7A:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v72 ALDOLASE

(Pseudomonas
putida) 		PF01212
(Beta_elim_lyase) 		4 ALA A 118
ASP A 160
ASP A 122
ILE A 123
 None
 0.84A 6fbnA-1v72A:
undetectable		 6fbnA-1v72A:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w25 STALKED-CELL
DIFFERENTIATION
CONTROLLING PROTEIN

(Caulobacter
vibrioides) 		PF00072
(Response_reg)
PF00990
(GGDEF) 		4 ALA A 351
ASP A 329
ILE A 328
ILE A 334
 None
 0.96A 6fbnA-1w25A:
undetectable		 6fbnA-1w25A:
24.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xbt THYMIDINE KINASE,
CYTOSOLIC

(Homo sapiens) 		PF00265
(TK) 		4 ALA A  88
ASP A  97
ILE A  96
ILE A 105
 None
MG  A1194 ( 4.3A)
None
None
 0.90A 6fbnA-1xbtA:
undetectable		 6fbnA-1xbtA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yzp PEROXIDASE
MANGANESE-DEPENDENT
I

(Phanerochaete
chrysosporium) 		PF00141
(peroxidase)
PF11895
(Peroxidase_ext) 		4 ALA A 135
GLU A  74
ASP A  84
ILE A  91
 None
CA  A 372 ( 4.3A)
None
None
 0.92A 6fbnA-1yzpA:
undetectable		 6fbnA-1yzpA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zfj INOSINE
MONOPHOSPHATE
DEHYDROGENASE

(Streptococcus
pyogenes) 		PF00478
(IMPDH)
PF00571
(CBS) 		4 ALA A 295
ASP A 253
ILE A 252
ILE A 250
 None
IMP  A 500 ( 4.7A)
None
None
 0.96A 6fbnA-1zfjA:
undetectable		 6fbnA-1zfjA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zkj EXTENDED-SPECTRUM
BETA-LACTAMASE

(Klebsiella
aerogenes) 		PF00144
(Beta-lactamase) 		4 ALA A 337
ASP A  14
ILE A  17
ILE A 353
 None
ZN  A 514 (-3.1A)
None
None
 0.90A 6fbnA-1zkjA:
undetectable		 6fbnA-1zkjA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2as9 SERINE PROTEASE

(Staphylococcus
aureus) 		PF00089
(Trypsin) 		4 GLU A 168
ILE A 170
ASP A 115
ILE A 139
 None
 0.70A 6fbnA-2as9A:
undetectable		 6fbnA-2as9A:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cav PROTEIN (CANAVALIN)

(Canavalia
ensiformis) 		PF00190
(Cupin_1) 		4 ALA A 137
ASP A 280
ILE A 281
ILE A 164
 None
 0.97A 6fbnA-2cavA:
undetectable		 6fbnA-2cavA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g7h METHYLATED-DNA--PROT
EIN-CYSTEINE
METHYLTRANSFERASE

(Methanocaldococcus
jannaschii) 		PF01035
(DNA_binding_1) 		4 ALA A 116
ASP A 101
ILE A 102
ILE A  91
 None
 0.79A 6fbnA-2g7hA:
undetectable		 6fbnA-2g7hA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i25 NEW ANTIGEN RECEPTOR
PBLA8

(Ginglymostoma
cirratum) 		PF07686
(V-set) 		4 GLU N  47
ILE N  49
ASP N  77
ILE N  70
 None
 0.96A 6fbnA-2i25N:
undetectable		 6fbnA-2i25N:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iy8 PROTEIN PM0188

(Pasteurella
multocida) 		PF11477
(PM0188) 		4 ALA A 208
ASP A 156
ILE A 157
ILE A 184
 None
 0.98A 6fbnA-2iy8A:
undetectable		 6fbnA-2iy8A:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j4l URIDYLATE KINASE

(Sulfolobus
solfataricus) 		PF00696
(AA_kinase) 		4 ALA A 138
ASP A 212
ILE A 213
ASP A 142
 None
 0.97A 6fbnA-2j4lA:
undetectable		 6fbnA-2j4lA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lru SERINE/THREONINE-PRO
TEIN KINASE WNK1

(Rattus
norvegicus) 		PF12202
(OSR1_C) 		4 ALA A 557
ASP A 518
ILE A 506
ASP A 550
 None
 0.85A 6fbnA-2lruA:
undetectable		 6fbnA-2lruA:
14.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2obv S-ADENOSYLMETHIONINE
SYNTHETASE ISOFORM
TYPE-1

(Homo sapiens) 		PF00438
(S-AdoMet_synt_N)
PF02772
(S-AdoMet_synt_M)
PF02773
(S-AdoMet_synt_C) 		7 ALA A  55
GLU A  70
ASP A 116
ILE A 117
ASP A 134
LYS A 289
ILE A 322
 None
 0.35A 6fbnA-2obvA:
60.8		 6fbnA-2obvA:
85.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pcn S-ADENOSYLMETHIONINE
:2-DEMETHYLMENAQUINO
NE METHYLTRANSFERASE

(Geobacillus
kaustophilus) 		PF03737
(RraA-like) 		4 ALA A 111
ASP A  76
ILE A 102
ILE A 107
 None
 0.88A 6fbnA-2pcnA:
undetectable		 6fbnA-2pcnA:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vrt RIBONUCLEASE E

(Escherichia
coli) 		PF00575
(S1)
PF10150
(RNase_E_G) 		4 ALA A  74
GLU A  76
ILE A 101
ILE A  41
 None
 0.94A 6fbnA-2vrtA:
undetectable		 6fbnA-2vrtA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x0i MALATE DEHYDROGENASE

(Archaeoglobus
fulgidus) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		4 ALA A 202
ASP A 304
ILE A 305
ILE A 268
 None
 0.85A 6fbnA-2x0iA:
undetectable		 6fbnA-2x0iA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yv9 CHLORIDE
INTRACELLULAR
CHANNEL EXC-4

(Caenorhabditis
elegans) 		no annotation 4 GLU A 259
ASP A 240
ILE A 244
ILE A 204
 None
 0.96A 6fbnA-2yv9A:
undetectable		 6fbnA-2yv9A:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3asi NEUREXIN-1-ALPHA

(Bos taurus) 		PF02210
(Laminin_G_2) 		4 ALA A1008
GLU A 919
ILE A 905
ILE A 991
 None
 0.92A 6fbnA-3asiA:
undetectable		 6fbnA-3asiA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cih PUTATIVE
ALPHA-RHAMNOSIDASE

(Bacteroides
thetaiotaomicron) 		PF17389
(Bac_rhamnosid6H)
PF17390
(Bac_rhamnosid_C) 		4 GLU A 223
ILE A 334
ASP A 332
ILE A 331
 None
None
TRS  A 800 (-3.6A)
None
 0.94A 6fbnA-3cihA:
undetectable		 6fbnA-3cihA:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cwr TRANSCRIPTIONAL
REGULATOR, TETR
FAMILY

(Rhodospirillum
rubrum) 		PF00440
(TetR_N) 		4 ALA A 162
ASP A  96
ILE A  97
ILE A  72
 None
 0.81A 6fbnA-3cwrA:
undetectable		 6fbnA-3cwrA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3etn PUTATIVE
PHOSPHOSUGAR
ISOMERASE INVOLVED
IN CAPSULE FORMATION

(Bacteroides
fragilis) 		PF01380
(SIS) 		4 ALA A  28
ASP A 165
ILE A 166
ILE A  19
 None
 0.89A 6fbnA-3etnA:
undetectable		 6fbnA-3etnA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ffs INOSINE-5-MONOPHOSPH
ATE DEHYDROGENASE

(Cryptosporidium
parvum) 		PF00478
(IMPDH) 		4 ALA A 155
ASP A 186
ILE A 185
ILE A 179
 None
 0.92A 6fbnA-3ffsA:
undetectable		 6fbnA-3ffsA:
24.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fvb BACTERIOFERRITIN

(Brucella
abortus) 		PF00210
(Ferritin) 		4 ALA A  97
GLU A 127
ASP A 132
ILE A 131
 IMD  A 171 (-3.4A)
FE  A 164 ( 2.5A)
None
None
 0.92A 6fbnA-3fvbA:
undetectable		 6fbnA-3fvbA:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gs3 SYMPLEKIN

(Drosophila
melanogaster) 		PF11935
(DUF3453) 		4 ALA A 177
ASP A 228
ILE A 229
ASP A 164
 None
 0.95A 6fbnA-3gs3A:
undetectable		 6fbnA-3gs3A:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gvy BACTERIOFERRITIN

(Rhodobacter
sphaeroides) 		PF00210
(Ferritin) 		4 ALA A  97
GLU A 127
ASP A 132
ASP A  90
 None
FE  A 163 (-2.0A)
None
None
 0.82A 6fbnA-3gvyA:
undetectable		 6fbnA-3gvyA:
15.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gvy BACTERIOFERRITIN

(Rhodobacter
sphaeroides) 		PF00210
(Ferritin) 		4 ALA A  97
GLU A 127
ASP A 132
ILE A 131
 None
FE  A 163 (-2.0A)
None
None
 0.81A 6fbnA-3gvyA:
undetectable		 6fbnA-3gvyA:
15.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3il0 AMINOPEPTIDASE P
XAA-PRO
AMINOPEPTIDASE

(Streptococcus
thermophilus) 		PF01321
(Creatinase_N) 		4 ALA A  19
ASP A  78
ILE A  79
ILE A 108
 None
 0.94A 6fbnA-3il0A:
undetectable		 6fbnA-3il0A:
17.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3iml S-ADENOSYLMETHIONINE
SYNTHETASE

(Burkholderia
pseudomallei) 		PF00438
(S-AdoMet_synt_N)
PF02772
(S-AdoMet_synt_M)
PF02773
(S-AdoMet_synt_C) 		4 ALA A  42
GLU A  57
ASP A 122
LYS A 273
 None
 0.49A 6fbnA-3imlA:
51.4		 6fbnA-3imlA:
53.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iz3 STRUCTURAL PROTEIN
VP1

(Cypovirus 1) 		no annotation 4 GLU B1143
ASP B1167
ILE B1141
ILE B1155
 None
 0.92A 6fbnA-3iz3B:
undetectable		 6fbnA-3iz3B:
14.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mq4 METABOTROPIC
GLUTAMATE RECEPTOR 7

(Homo sapiens) 		PF01094
(ANF_receptor) 		4 ALA A 282
ASP A 211
ILE A 212
ILE A 336
 None
 0.98A 6fbnA-3mq4A:
undetectable		 6fbnA-3mq4A:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nix FLAVOPROTEIN/DEHYDRO
GENASE

(Cytophaga
hutchinsonii) 		PF01494
(FAD_binding_3) 		4 ASP A 131
ILE A 132
ASP A 160
ILE A  11
 None
None
None
FAD  A 501 (-4.9A)
 0.93A 6fbnA-3nixA:
undetectable		 6fbnA-3nixA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nm1 THIAMINE
BIOSYNTHETIC
BIFUNCTIONAL ENZYME

([Candida]
glabrata) 		PF02110
(HK)
PF02581
(TMP-TENI) 		4 ALA A 413
ASP A 444
ILE A 445
ILE A 427
 None
 0.64A 6fbnA-3nm1A:
undetectable		 6fbnA-3nm1A:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ren GLYCOSYL HYDROLASE,
FAMILY 8

(Clostridium
perfringens) 		PF01270
(Glyco_hydro_8) 		4 ALA A 326
ILE A 313
ASP A 319
ILE A 317
 None
 0.88A 6fbnA-3renA:
undetectable		 6fbnA-3renA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3snx PUTATIVE SUSD-LIKE
CARBOHYDRATE BINDING
PROTEIN

(Bacteroides
thetaiotaomicron) 		PF07980
(SusD_RagB)
PF14322
(SusD-like_3) 		4 ALA A 287
GLU A  59
ASP A 347
ILE A 269
 None
 0.69A 6fbnA-3snxA:
undetectable		 6fbnA-3snxA:
20.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3so4 METHIONINE-ADENOSYLT
RANSFERASE

(Entamoeba
histolytica) 		PF00438
(S-AdoMet_synt_N)
PF02772
(S-AdoMet_synt_M)
PF02773
(S-AdoMet_synt_C) 		5 ALA A  42
GLU A  57
ASP A 121
LYS A 276
ILE A 309
 None
 0.74A 6fbnA-3so4A:
55.3		 6fbnA-3so4A:
60.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3stp GALACTONATE
DEHYDRATASE,
PUTATIVE

(Labrenzia
aggregata) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 GLU A  96
ASP A  90
ASP A 119
ILE A 122
 None
 0.74A 6fbnA-3stpA:
undetectable		 6fbnA-3stpA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tfj GCVT-LIKE
AMINOMETHYLTRANSFERA
SE PROTEIN

(Candidatus
Pelagibacter
ubique) 		PF01571
(GCV_T)
PF08669
(GCV_T_C) 		4 ALA A 337
ASP A 298
ILE A 297
ILE A 354
 None
 0.94A 6fbnA-3tfjA:
undetectable		 6fbnA-3tfjA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tr2 OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE

(Coxiella
burnetii) 		PF00215
(OMPdecase) 		4 ALA A 202
ASP A 230
ILE A 229
ILE A 216
 None
 0.92A 6fbnA-3tr2A:
undetectable		 6fbnA-3tr2A:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tv2 FUMARATE HYDRATASE,
CLASS II

(Burkholderia
pseudomallei) 		PF00206
(Lyase_1)
PF10415
(FumaraseC_C) 		4 ALA A 197
GLU A 389
ASP A 218
ILE A 221
 None
 0.85A 6fbnA-3tv2A:
undetectable		 6fbnA-3tv2A:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ufa SERINE PROTEASE SPLA

(Staphylococcus
aureus) 		PF00089
(Trypsin) 		4 GLU A 164
ILE A 166
ASP A 111
ILE A 135
 None
 0.76A 6fbnA-3ufaA:
undetectable		 6fbnA-3ufaA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vx6 E1

(Kluyveromyces
marxianus) 		PF16420
(ATG7_N) 		4 ASP A 161
ILE A 162
LYS A 194
ILE A 181
 None
 0.96A 6fbnA-3vx6A:
undetectable		 6fbnA-3vx6A:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4czp EXTRALONG MANGANESE
PEROXIDASE

(Gelatoporia
subvermispora) 		PF00141
(peroxidase)
PF11895
(Peroxidase_ext) 		4 ALA A 135
GLU A  74
ASP A  84
ILE A  91
 None
CA  A1371 ( 4.5A)
None
None
 0.90A 6fbnA-4czpA:
undetectable		 6fbnA-4czpA:
23.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ea1 DEHYDROSQUALENE
SYNTHASE

(Staphylococcus
aureus) 		PF00494
(SQS_PSY) 		4 GLU A  71
ASP A  66
ILE A  67
ILE A 108
 None
 0.89A 6fbnA-4ea1A:
undetectable		 6fbnA-4ea1A:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ikn AP-3 COMPLEX SUBUNIT
MU-1

(Rattus
norvegicus) 		PF00928
(Adap_comp_sub) 		4 GLU A 185
ASP A 188
ILE A 187
ILE A 272
 GLU  A 185 ( 0.6A)
ASP  A 188 ( 0.6A)
ILE  A 187 ( 0.6A)
ILE  A 272 ( 0.7A)
 0.84A 6fbnA-4iknA:
undetectable		 6fbnA-4iknA:
23.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4js1 BETA-GALACTOSIDE
ALPHA-2,6-SIALYLTRAN
SFERASE 1

(Homo sapiens) 		PF00777
(Glyco_transf_29) 		4 ALA A 190
GLU A 342
ASP A 339
ILE A 328
 CTN  A 510 (-3.3A)
None
None
None
 0.80A 6fbnA-4js1A:
undetectable		 6fbnA-4js1A:
20.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4le5 S-ADENOSYLMETHIONINE
SYNTHETASE

(Campylobacter
jejuni) 		PF00438
(S-AdoMet_synt_N)
PF02772
(S-AdoMet_synt_M)
PF02773
(S-AdoMet_synt_C) 		5 ALA A  39
GLU A  54
ASP A 124
LYS A 281
ILE A 314
 None
 0.37A 6fbnA-4le5A:
49.0		 6fbnA-4le5A:
38.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lkr PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE

(Shewanella
oneidensis) 		PF01048
(PNP_UDP_1) 		4 ALA A 169
ASP A 179
ILE A 178
ASP A 161
 None
 0.89A 6fbnA-4lkrA:
undetectable		 6fbnA-4lkrA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mps BETA-GALACTOSIDE
ALPHA-2,6-SIALYLTRAN
SFERASE 1

(Rattus
norvegicus) 		PF00777
(Glyco_transf_29) 		4 ALA A 187
GLU A 339
ASP A 336
ILE A 325
 None
 0.68A 6fbnA-4mpsA:
undetectable		 6fbnA-4mpsA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nhd 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3 PROTEIN 1

(Vibrio cholerae) 		PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III) 		4 ALA A 105
ASP A  72
ILE A  73
ILE A  63
 None
 0.84A 6fbnA-4nhdA:
undetectable		 6fbnA-4nhdA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nwz FAD-DEPENDENT
PYRIDINE
NUCLEOTIDE-DISULFIDE
OXIDOREDUCTASE

(Caldalkalibacillus
thermarum) 		PF07992
(Pyr_redox_2) 		4 ALA A  18
ASP A  32
ILE A   6
ILE A 334
 None
 0.86A 6fbnA-4nwzA:
undetectable		 6fbnA-4nwzA:
23.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4odj S-ADENOSYLMETHIONINE
SYNTHASE

(Cryptosporidium
hominis) 		PF00438
(S-AdoMet_synt_N)
PF02772
(S-AdoMet_synt_M)
PF02773
(S-AdoMet_synt_C) 		6 ALA A  60
GLU A  75
ILE A 122
ASP A 139
LYS A 297
ILE A 330
 None
 0.32A 6fbnA-4odjA:
58.0		 6fbnA-4odjA:
56.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p4s INTERFERON-INDUCED
GTP-BINDING PROTEIN
MX1

(Homo sapiens) 		PF00350
(Dynamin_N)
PF01031
(Dynamin_M) 		4 ALA A 146
ASP A 135
ILE A 133
ILE A 166
 None
 0.92A 6fbnA-4p4sA:
undetectable		 6fbnA-4p4sA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p4s INTERFERON-INDUCED
GTP-BINDING PROTEIN
MX1

(Homo sapiens) 		PF00350
(Dynamin_N)
PF01031
(Dynamin_M) 		4 ALA B 146
ASP B 135
ILE B 133
ILE B 166
 None
 0.92A 6fbnA-4p4sB:
undetectable		 6fbnA-4p4sB:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r37 PUTATIVE
ACYL-[ACYL-CARRIER-P
ROTEIN]--UDP-N-ACETY
LGLUCOSAMINE
O-ACYLTRANSFERASE

(Bacteroides
fragilis) 		PF00132
(Hexapep)
PF13720
(Acetyltransf_11) 		4 ALA A 225
ASP A 173
ILE A 253
ILE A 178
 None
 0.81A 6fbnA-4r37A:
undetectable		 6fbnA-4r37A:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rv2 UPF0336 PROTEIN
MSMEG_1340/MSMEI_130
2

(Mycolicibacterium
smegmatis) 		PF13452
(MaoC_dehydrat_N) 		4 ALA A 131
GLU A 133
ASP A 101
ILE A  97
 None
 0.93A 6fbnA-4rv2A:
undetectable		 6fbnA-4rv2A:
17.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ry8 PERIPLASMIC BINDING
PROTEIN

(Pseudothermotoga
lettingae) 		PF13407
(Peripla_BP_4) 		4 ALA A 324
ASP A 255
ILE A 256
ILE A 260
 None
 0.97A 6fbnA-4ry8A:
undetectable		 6fbnA-4ry8A:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4toc BACTERIOFERRITIN

(Pseudomonas
aeruginosa) 		PF00210
(Ferritin) 		4 ALA A  97
GLU A 127
ASP A 132
ASP A  90
 None
FE2  A 203 ( 2.5A)
None
None
 0.95A 6fbnA-4tocA:
undetectable		 6fbnA-4tocA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4toc BACTERIOFERRITIN

(Pseudomonas
aeruginosa) 		PF00210
(Ferritin) 		4 ALA A  97
GLU A 127
ASP A 132
ILE A 131
 None
FE2  A 203 ( 2.5A)
None
None
 0.86A 6fbnA-4tocA:
undetectable		 6fbnA-4tocA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u9c LACTOFERRIN-BINDING
PROTEIN B

(Neisseria
meningitidis) 		PF01298
(TbpB_B_D)
PF17484
(TbpB_A) 		4 ALA A  46
ASP A  85
ILE A  86
ILE A 329
 None
 0.92A 6fbnA-4u9cA:
undetectable		 6fbnA-4u9cA:
24.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w6q GLUCOSYLTRANSFERASE

(Streptococcus
agalactiae) 		no annotation 4 ASP A  66
ILE A  67
ASP A 125
ILE A  95
 None
 0.81A 6fbnA-4w6qA:
undetectable		 6fbnA-4w6qA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xuy PROBABLE
ENDO-1,4-BETA-XYLANA
SE C

(Aspergillus
niger) 		PF00331
(Glyco_hydro_10) 		4 ALA A 324
ASP A 311
ASP A  65
ILE A  61
 None
None
PCA  A  26 ( 4.2A)
PCA  A  26 ( 4.5A)
 0.97A 6fbnA-4xuyA:
undetectable		 6fbnA-4xuyA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yeh LECTIN

(Cicer arietinum) 		PF00045
(Hemopexin) 		4 ALA A  18
ASP A 174
ILE A   6
ILE A 224
 None
 0.96A 6fbnA-4yehA:
undetectable		 6fbnA-4yehA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z0v 2',5'-PHOSPHODIESTER
ASE 12

(Homo sapiens) 		PF03372
(Exo_endo_phos) 		4 ALA A 476
ASP A 398
ILE A 399
ASP A 408
 None
 0.88A 6fbnA-4z0vA:
undetectable		 6fbnA-4z0vA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z2a FURIN

(Homo sapiens) 		PF00082
(Peptidase_S8)
PF01483
(P_proprotein) 		4 ALA A 375
ASP A 168
ILE A 221
ILE A 156
 None
 0.97A 6fbnA-4z2aA:
undetectable		 6fbnA-4z2aA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zmm DIGUANYLATE CYCLASE

(Pseudomonas
aeruginosa) 		PF00990
(GGDEF) 		4 ALA A 243
ASP A 221
ILE A 220
ILE A 226
 None
 0.97A 6fbnA-4zmmA:
undetectable		 6fbnA-4zmmA:
20.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5a1i S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2

(Homo sapiens) 		PF00438
(S-AdoMet_synt_N)
PF02772
(S-AdoMet_synt_M)
PF02773
(S-AdoMet_synt_C) 		7 ALA A  55
GLU A  70
ASP A 116
ILE A 117
ASP A 134
LYS A 289
ILE A 322
 None
 0.28A 6fbnA-5a1iA:
60.3		 6fbnA-5a1iA:
99.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b5q MEMBRANE THIOL
PROTEASE

(Chlamydia
trachomatis) 		PF02902
(Peptidase_C48) 		4 ALA B 194
ASP B 209
ILE B 206
ILE B 186
 None
 0.78A 6fbnA-5b5qB:
undetectable		 6fbnA-5b5qB:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e38 URACIL
PHOSPHORIBOSYLTRANSF
ERASE

(Mycobacterium
tuberculosis) 		PF14681
(UPRTase) 		4 ALA A  -4
ASP A 183
ILE A 182
ILE A 165
 None
 0.96A 6fbnA-5e38A:
undetectable		 6fbnA-5e38A:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h2v IMPORTIN SUBUNIT
BETA-3

(Saccharomyces
cerevisiae) 		PF13513
(HEAT_EZ) 		4 ALA A   3
GLU A  53
ILE A 102
ILE A  94
 None
 0.86A 6fbnA-5h2vA:
undetectable		 6fbnA-5h2vA:
15.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5h9u S-ADENOSYLMETHIONINE
SYNTHASE

(Thermus
thermophilus) 		no annotation 4 ALA C  42
GLU C  57
ASP C 130
LYS C 282
 None
 0.62A 6fbnA-5h9uC:
54.2		 6fbnA-5h9uC:
50.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i4e MYOSIN-14,ALPHA-ACTI
NIN A

(Homo sapiens;
Dictyostelium
discoideum) 		PF00063
(Myosin_head)
PF00435
(Spectrin)
PF02736
(Myosin_N) 		4 ALA A 181
ASP A 478
ILE A 476
ILE A 212
 None
MG  A1501 ( 4.6A)
None
None
 0.98A 6fbnA-5i4eA:
undetectable		 6fbnA-5i4eA:
17.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iri SERINE/THREONINE-PRO
TEIN KINASE BRSK1

(Mus musculus) 		no annotation 4 ALA A 646
ASP A 623
ILE A 624
ILE A 667
 None
 0.90A 6fbnA-5iriA:
undetectable		 6fbnA-5iriA:
14.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l9w ACETOPHENONE
CARBOXYLASE DELTA
SUBUNIT

(Aromatoleum
aromaticum) 		PF02538
(Hydantoinase_B) 		4 ALA A 378
ASP A 289
ILE A 253
ILE A 339
 None
 0.93A 6fbnA-5l9wA:
undetectable		 6fbnA-5l9wA:
20.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5t8t S-ADENOSYLMETHIONINE
SYNTHASE

(Neisseria
gonorrhoeae) 		PF00438
(S-AdoMet_synt_N)
PF02772
(S-AdoMet_synt_M)
PF02773
(S-AdoMet_synt_C) 		7 ALA A  41
GLU A  56
ASP A 102
ILE A 103
ASP A 121
LYS A 274
ILE A 307
 None
 0.48A 6fbnA-5t8tA:
55.3		 6fbnA-5t8tA:
55.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vf4 UNCHARACTERIZED
PROTEIN

(Thermus
aquaticus) 		PF03781
(FGE-sulfatase) 		4 ALA A 236
GLU A 211
ASP A 256
ILE A 310
 None
 0.93A 6fbnA-5vf4A:
undetectable		 6fbnA-5vf4A:
25.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vsj ALPHA-1,4-GLUCAN:MAL
TOSE-1-PHOSPHATE
MALTOSYLTRANSFERASE
1

(Streptomyces
coelicolor) 		PF00128
(Alpha-amylase)
PF11896
(DUF3416) 		4 ALA A 136
GLU A 133
ASP A 127
ILE A 122
 None
 0.90A 6fbnA-5vsjA:
undetectable		 6fbnA-5vsjA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wti CRISPR-ASSOCIATED
PROTEIN

(Bacillus
thermoamylovorans) 		no annotation 4 ALA Z 803
ASP Z 574
ILE Z 573
ILE Z 855
 None
MG  Z1202 (-2.3A)
None
None
 0.93A 6fbnA-5wtiZ:
undetectable		 6fbnA-5wtiZ:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wug BETA-GLUCOSIDASE

(Paenibacillus
barengoltzii) 		no annotation 4 ALA A 166
ASP A 210
ILE A 209
ILE A 162
 None
 0.84A 6fbnA-5wugA:
undetectable		 6fbnA-5wugA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xfm ALPHA-GLUCOSIDASE

(Bacteroides
thetaiotaomicron) 		no annotation 4 ALA A 356
ASP A 337
ILE A 336
ILE A 344
 None
 0.91A 6fbnA-5xfmA:
undetectable		 6fbnA-5xfmA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xnz CRED

(Streptomyces
cremeus) 		no annotation 4 ALA A 136
ASP A 263
ILE A 260
ILE A 301
 None
 0.97A 6fbnA-5xnzA:
undetectable		 6fbnA-5xnzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5za2 BETA-LACTAMASE

(Escherichia
coli) 		no annotation 4 ALA A 339
ASP A  13
ILE A  16
ILE A 355
 None
 0.91A 6fbnA-5za2A:
undetectable		 6fbnA-5za2A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6am0 KLLA0F23980P

(Kluyveromyces
lactis) 		no annotation 4 ALA A  91
ASP A  76
ILE A  75
ILE A  81
 None
 0.93A 6fbnA-6am0A:
undetectable		 6fbnA-6am0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ape BIFUNCTIONAL PROTEIN
FOLD

(Helicobacter
pylori) 		PF00763
(THF_DHG_CYH)
PF02882
(THF_DHG_CYH_C) 		4 ALA A 228
ASP A 246
ILE A 219
ILE A 199
 None
GOL  A 303 ( 4.8A)
None
None
 0.78A 6fbnA-6apeA:
undetectable		 6fbnA-6apeA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bc5 AAC 3-VI PROTEIN

(Enterobacter
cloacae) 		no annotation 4 ALA A 195
ASP A 247
ILE A 244
ILE A 272
 None
 0.93A 6fbnA-6bc5A:
undetectable		 6fbnA-6bc5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d3u ULVAN LYASE

(Nonlabens
ulvanivorans) 		no annotation 4 ALA A 254
ASP A 199
ILE A 200
ILE A 142
 None
 0.89A 6fbnA-6d3uA:
undetectable		 6fbnA-6d3uA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ehi NUCLEASE NUCT

(Helicobacter
pylori) 		no annotation 4 ALA A 116
ASP A  39
ILE A  40
ILE A  21
 ACT  A 201 (-3.6A)
None
None
None
 0.88A 6fbnA-6ehiA:
undetectable		 6fbnA-6ehiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6et7 DIGUANYLATE CYCLASE
(GGDEF)
DOMAIN-CONTAINING
PROTEIN

(Idiomarina sp.
A28L) 		no annotation 4 ALA A 334
ASP A 350
ASP A 498
ILE A 495
 None
 0.96A 6fbnA-6et7A:
undetectable		 6fbnA-6et7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6evg MULTI-COPPER OXIDASE
CUEO

(Ochrobactrum) 		no annotation 4 ALA A 417
ASP A 462
ILE A 438
ILE A 472
 None
 0.91A 6fbnA-6evgA:
undetectable		 6fbnA-6evgA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gru ADP-SUGAR
PYROPHOSPHATASE

(Homo sapiens) 		no annotation 4 ALA A 124
GLU A 125
ILE A  65
ILE A  77
 None
 0.86A 6fbnA-6gruA:
undetectable		 6fbnA-6gruA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1awb MYO-INOSITOL
MONOPHOSPHATASE

(Homo sapiens) 		PF00459
(Inositol_P) 		4 PRO A  91
ASP A  90
SER A 165
ASP A  47
 CA  A   1 ( 4.9A)
CA  A 278 (-2.7A)
IPD  A 281 ( 3.8A)
None
 1.11A 6fbnB-1awbA:
undetectable		 6fbnB-1awbA:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cen CELLULASE CELC

(Ruminiclostridium
thermocellum) 		PF00150
(Cellulase) 		4 PRO A  52
SER A  21
PHE A  25
ASP A  50
 None
 1.07A 6fbnB-1cenA:
undetectable		 6fbnB-1cenA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ee6 PECTATE LYASE

(Bacillus sp.
KSM-P15) 		PF03211
(Pectate_lyase) 		4 HIS A  66
PRO A  42
LYS A  89
SER A  90
 None
 1.20A 6fbnB-1ee6A:
undetectable		 6fbnB-1ee6A:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iip CYCLOPHILIN 40

(Bos taurus) 		PF00160
(Pro_isomerase)
PF13176
(TPR_7) 		4 PRO A 194
ASP A 196
PHE A 233
ASP A 200
 None
 1.13A 6fbnB-1iipA:
undetectable		 6fbnB-1iipA:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lf9 GLUCOAMYLASE

(Thermoanaerobacterium
thermosaccharolyticum) 		PF00723
(Glyco_hydro_15)
PF09137
(Glucodextran_N) 		4 LYS A  83
SER A  84
PHE A  85
ASP A 148
 None
 1.18A 6fbnB-1lf9A:
undetectable		 6fbnB-1lf9A:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ltz PHENYLALANINE-4-HYDR
OXYLASE

(Chromobacterium
violaceum) 		PF00351
(Biopterin_H) 		4 HIS A 138
PRO A 134
ASP A 139
PHE A 116
 FE  A 400 (-3.3A)
None
HBI  A 500 ( 4.9A)
None
 1.03A 6fbnB-1ltzA:
undetectable		 6fbnB-1ltzA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1miq PLASMEPSIN

(Plasmodium
vivax) 		PF00026
(Asp) 		4 ASP A 107
SER A  50
SER A 116
ASP A 110
 None
 1.14A 6fbnB-1miqA:
undetectable		 6fbnB-1miqA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q5d P450 EPOXIDASE

(Sorangium
cellulosum) 		PF00067
(p450) 		4 HIS A 400
PRO A 401
ASP A 192
SER A 201
 None
 1.21A 6fbnB-1q5dA:
undetectable		 6fbnB-1q5dA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qs8 PLASMEPSIN

(Plasmodium
vivax) 		PF00026
(Asp) 		4 ASP A 107
SER A  50
SER A 116
ASP A 110
 None
 1.15A 6fbnB-1qs8A:
undetectable		 6fbnB-1qs8A:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rdr POLIOVIRUS 3D
POLYMERASE

(Enterovirus C) 		PF00680
(RdRP_1) 		4 HIS A 423
PRO A 390
PHE A 461
ASP A 215
 None
 1.17A 6fbnB-1rdrA:
undetectable		 6fbnB-1rdrA:
23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v26 LONG-CHAIN-FATTY-ACI
D-COA SYNTHETASE

(Thermus
thermophilus) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		4 HIS A  41
PRO A 127
SER A  38
ASP A 150
 None
 1.19A 6fbnB-1v26A:
undetectable		 6fbnB-1v26A:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v7v CHITOBIOSE
PHOSPHORYLASE

(Vibrio
proteolyticus) 		PF06165
(Glyco_transf_36)
PF17167
(Glyco_hydro_36) 		4 HIS A 385
SER A 425
SER A 501
ASP A 492
 None
 1.18A 6fbnB-1v7vA:
undetectable		 6fbnB-1v7vA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wb0 CHITOTRIOSIDASE 1

(Homo sapiens) 		PF00704
(Glyco_hydro_18) 		4 PRO A 325
SER A 308
SER A 371
ASP A 338
 None
None
None
IPA  A1393 (-3.5A)
 1.22A 6fbnB-1wb0A:
undetectable		 6fbnB-1wb0A:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xr5 GENOME POLYPROTEIN

(Rhinovirus B) 		PF00680
(RdRP_1) 		4 HIS A 422
PRO A 389
PHE A 460
ASP A 215
 None
 1.19A 6fbnB-1xr5A:
undetectable		 6fbnB-1xr5A:
22.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1xrc S-ADENOSYLMETHIONINE
SYNTHETASE

(Escherichia
coli) 		PF00438
(S-AdoMet_synt_N)
PF02772
(S-AdoMet_synt_M)
PF02773
(S-AdoMet_synt_C) 		7 HIS A  14
PRO A  15
ASP A 163
LYS A 165
SER A 186
PHE A 230
ASP A 238
 None
 0.62A 6fbnB-1xrcA:
51.3		 6fbnB-1xrcA:
54.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yb4 TARTRONIC
SEMIALDEHYDE
REDUCTASE

(Salmonella
enterica) 		PF03446
(NAD_binding_2)
PF14833
(NAD_binding_11) 		4 ASP A 116
LYS A 101
SER A 245
ASP A 164
 None
 1.02A 6fbnB-1yb4A:
undetectable		 6fbnB-1yb4A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yq2 BETA-GALACTOSIDASE

(Arthrobacter
sp. C2-2) 		PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF02929
(Bgal_small_N)
PF16353
(DUF4981) 		4 HIS A 373
PRO A 374
PHE A 209
ASP A 144
 None
 1.22A 6fbnB-1yq2A:
undetectable		 6fbnB-1yq2A:
17.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bji INOSITOL-1(OR
4)-MONOPHOSPHATASE

(Bos taurus) 		PF00459
(Inositol_P) 		4 PRO A1091
ASP A1090
SER A1165
ASP A1047
 MG  A2277 ( 4.8A)
MG  A2278 ( 2.5A)
None
None
 1.20A 6fbnB-2bjiA:
undetectable		 6fbnB-2bjiA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c11 MEMBRANE COPPER
AMINE OXIDASE

(Homo sapiens) 		PF01179
(Cu_amine_oxid)
PF02727
(Cu_amine_oxidN2)
PF02728
(Cu_amine_oxidN3) 		4 HIS A 112
PRO A 119
SER A 338
PHE A  60
 CU  A1740 (-3.5A)
None
None
None
 1.18A 6fbnB-2c11A:
undetectable		 6fbnB-2c11A:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f15 5'-AMP-ACTIVATED
PROTEIN KINASE,
BETA-2 SUBUNIT

(Homo sapiens) 		PF16561
(AMPK1_CBM) 		4 HIS A 123
PRO A 119
SER A  93
SER A 100
 None
 1.22A 6fbnB-2f15A:
undetectable		 6fbnB-2f15A:
11.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fuk XC6422 PROTEIN

(Xanthomonas
campestris) 		PF12146
(Hydrolase_4) 		4 PRO A  18
SER A  79
SER A  47
ASP A  95
 None
 1.03A 6fbnB-2fukA:
undetectable		 6fbnB-2fukA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fuk XC6422 PROTEIN

(Xanthomonas
campestris) 		PF12146
(Hydrolase_4) 		4 SER A  47
SER A  79
PHE A  87
ASP A  91
 None
 1.18A 6fbnB-2fukA:
undetectable		 6fbnB-2fukA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gzb KUNITZ-TYPE
PROTEINASE INHIBITOR
BBCI

(Bauhinia
bauhinioides) 		PF00197
(Kunitz_legume) 		4 HIS A  49
PRO A  48
ASP A  47
ASP A 142
 None
 1.13A 6fbnB-2gzbA:
undetectable		 6fbnB-2gzbA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ijd PICORNAIN 3C,
RNA-DIRECTED RNA
POLYMERASE

(Enterovirus C) 		PF00548
(Peptidase_C3)
PF00680
(RdRP_1) 		4 HIS 1 606
PRO 1 573
PHE 1 644
ASP 1 398
 None
 1.21A 6fbnB-2ijd1:
undetectable		 6fbnB-2ijd1:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2k3t FILAMIN-A

(Homo sapiens) 		PF00630
(Filamin) 		4 HIS A2506
PRO A2511
LYS A2500
SER A2463
 None
 0.79A 6fbnB-2k3tA:
undetectable		 6fbnB-2k3tA:
15.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2obv S-ADENOSYLMETHIONINE
SYNTHETASE ISOFORM
TYPE-1

(Homo sapiens) 		PF00438
(S-AdoMet_synt_N)
PF02772
(S-AdoMet_synt_M)
PF02773
(S-AdoMet_synt_C) 		8 HIS A  29
PRO A  30
ASP A 179
LYS A 181
SER A 206
SER A 247
PHE A 250
ASP A 258
 SAM  A 501 (-3.6A)
SAM  A 501 (-4.2A)
SAM  A 501 (-2.7A)
SAM  A 501 (-3.9A)
SAM  A 501 ( 3.7A)
SAM  A 501 (-2.8A)
SAM  A 501 (-3.4A)
SAM  A 501 (-3.6A)
 0.26A 6fbnB-2obvA:
54.9		 6fbnB-2obvA:
85.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pfr ARYLAMINE
N-ACETYLTRANSFERASE
2

(Homo sapiens) 		PF00797
(Acetyltransf_2) 		4 HIS A  30
ASP A  26
LYS A  13
SER A  15
 None
 1.21A 6fbnB-2pfrA:
undetectable		 6fbnB-2pfrA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qfq 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE

(Escherichia
coli) 		PF00275
(EPSP_synthase) 		4 HIS A 385
LYS A 411
SER A  25
ASP A 313
 FMT  A 601 (-4.3A)
FMT  A 602 (-2.8A)
None
S3P  A 701 ( 2.8A)
 1.07A 6fbnB-2qfqA:
undetectable		 6fbnB-2qfqA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xh6 HEAT-LABILE
ENTEROTOXIN B CHAIN

(Clostridium
perfringens) 		PF03505
(Clenterotox) 		4 ASP A  39
SER A 150
SER A  88
ASP A 260
 None
 1.18A 6fbnB-2xh6A:
undetectable		 6fbnB-2xh6A:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xio PUTATIVE
DEOXYRIBONUCLEASE
TATDN1

(Homo sapiens) 		PF01026
(TatD_DNase) 		4 HIS A  77
PRO A  78
SER A 199
ASP A 116
 None
 0.91A 6fbnB-2xioA:
undetectable		 6fbnB-2xioA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c9h ABC TRANSPORTER,
SUBSTRATE BINDING
PROTEIN

(Agrobacterium
fabrum) 		PF13416
(SBP_bac_8) 		4 PRO A 254
ASP A 256
SER A 200
PHE A 195
 None
 1.16A 6fbnB-3c9hA:
undetectable		 6fbnB-3c9hA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d45 POLY(A)-SPECIFIC
RIBONUCLEASE PARN

(Mus musculus) 		PF01424
(R3H)
PF04857
(CAF1)
PF08675
(RNA_bind) 		4 HIS A 439
PRO A 481
ASP A 438
LYS A 436
 None
 0.99A 6fbnB-3d45A:
undetectable		 6fbnB-3d45A:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3er6 PUTATIVE
TRANSCRIPTIONAL
REGULATOR PROTEIN

(Vibrio
parahaemolyticus) 		PF01965
(DJ-1_PfpI) 		4 HIS A 135
PRO A 169
ASP A 115
SER A  89
 None
 1.13A 6fbnB-3er6A:
undetectable		 6fbnB-3er6A:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g3o VACUOLAR TRANSPORTER
CHAPERONE 2

(Saccharomyces
cerevisiae) 		PF09359
(VTC) 		4 ASP A 284
SER A 521
PHE A 523
ASP A 293
 None
SO4  A1001 (-2.5A)
None
None
 0.95A 6fbnB-3g3oA:
undetectable		 6fbnB-3g3oA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h1g CHEMOTAXIS PROTEIN
CHEY HOMOLOG

(Helicobacter
pylori) 		PF00072
(Response_reg) 		4 HIS A  33
PRO A  57
ASP A   8
SER A  10
 None
None
MG  A 128 (-3.0A)
None
 1.19A 6fbnB-3h1gA:
undetectable		 6fbnB-3h1gA:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ij6 UNCHARACTERIZED
METAL-DEPENDENT
HYDROLASE

(Lactobacillus
acidophilus) 		PF04909
(Amidohydro_2) 		4 HIS A 225
ASP A 228
LYS A 224
ASP A 191
 None
 1.04A 6fbnB-3ij6A:
undetectable		 6fbnB-3ij6A:
21.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3iml S-ADENOSYLMETHIONINE
SYNTHETASE

(Burkholderia
pseudomallei) 		PF00438
(S-AdoMet_synt_N)
PF02772
(S-AdoMet_synt_M)
PF02773
(S-AdoMet_synt_C) 		6 HIS A  16
PRO A  17
ASP A 167
LYS A 169
SER A 190
PHE A 234
 None
 0.33A 6fbnB-3imlA:
49.6		 6fbnB-3imlA:
53.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3iml S-ADENOSYLMETHIONINE
SYNTHETASE

(Burkholderia
pseudomallei) 		PF00438
(S-AdoMet_synt_N)
PF02772
(S-AdoMet_synt_M)
PF02773
(S-AdoMet_synt_C) 		5 HIS A  16
PRO A  17
LYS A 169
SER A 190
ASP A 242
 None
 0.88A 6fbnB-3imlA:
49.6		 6fbnB-3imlA:
53.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m1r FORMIMIDOYLGLUTAMASE

(Bacillus
subtilis) 		PF00491
(Arginase) 		4 HIS A 152
ASP A 154
SER A  47
ASP A 242
 CA  A 322 (-3.4A)
CA  A 323 ( 2.5A)
None
CA  A 322 ( 2.9A)
 1.06A 6fbnB-3m1rA:
undetectable		 6fbnB-3m1rA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mpg DIHYDROOROTASE

(Bacillus
anthracis) 		PF01979
(Amidohydro_1) 		4 ASP A  57
SER A 394
PHE A 327
ASP A 304
 None
None
None
ZN  A 429 (-2.9A)
 1.17A 6fbnB-3mpgA:
undetectable		 6fbnB-3mpgA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nvs 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE

(Vibrio cholerae) 		PF00275
(EPSP_synthase) 		4 HIS A 386
LYS A 412
SER A  25
ASP A 314
 GPJ  A 429 (-4.3A)
GPJ  A 429 (-2.9A)
None
SKM  A 428 (-2.7A)
 1.06A 6fbnB-3nvsA:
undetectable		 6fbnB-3nvsA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pgy SERINE
HYDROXYMETHYLTRANSFE
RASE

(Staphylococcus
aureus) 		PF00464
(SHMT) 		4 HIS A 210
PRO A 211
SER A 175
SER A 305
 None
 1.14A 6fbnB-3pgyA:
undetectable		 6fbnB-3pgyA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r6n DESMOPLAKIN

(Homo sapiens) 		no annotation 4 HIS A 551
SER A 546
SER A 597
PHE A 600
 None
 1.21A 6fbnB-3r6nA:
undetectable		 6fbnB-3r6nA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r6n DESMOPLAKIN

(Homo sapiens) 		no annotation 4 SER A 546
SER A 597
PHE A 600
ASP A 406
 None
 1.10A 6fbnB-3r6nA:
undetectable		 6fbnB-3r6nA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rhg PUTATIVE
PHOPHOTRIESTERASE

(Proteus
mirabilis) 		PF02126
(PTE) 		4 HIS A 229
ASP A 253
SER A 226
SER A 195
 ZN  A 368 (-3.2A)
None
None
None
 1.13A 6fbnB-3rhgA:
undetectable		 6fbnB-3rhgA:
21.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3rv2 S-ADENOSYLMETHIONINE
SYNTHASE

(Mycobacterium
marinum) 		PF00438
(S-AdoMet_synt_N)
PF02772
(S-AdoMet_synt_M)
PF02773
(S-AdoMet_synt_C) 		7 HIS A  17
PRO A  18
ASP A 179
LYS A 181
SER A 202
PHE A 251
ASP A 259
 None
None
None
None
None
None
CA  A 404 (-3.4A)
 0.65A 6fbnB-3rv2A:
50.3		 6fbnB-3rv2A:
53.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rxz POLYSACCHARIDE
DEACETYLASE

(Mycolicibacterium
smegmatis) 		PF01522
(Polysacc_deac_1) 		4 HIS A 104
PRO A  80
SER A 110
ASP A  31
 ZN  A 299 (-3.4A)
None
None
ZN  A 299 (-2.1A)
 1.17A 6fbnB-3rxzA:
undetectable		 6fbnB-3rxzA:
21.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3so4 METHIONINE-ADENOSYLT
RANSFERASE

(Entamoeba
histolytica) 		PF00438
(S-AdoMet_synt_N)
PF02772
(S-AdoMet_synt_M)
PF02773
(S-AdoMet_synt_C) 		8 HIS A  16
PRO A  17
ASP A 166
LYS A 168
SER A 193
SER A 234
PHE A 237
ASP A 245
 None
None
None
ACT  A 400 ( 4.9A)
None
None
None
None
 0.66A 6fbnB-3so4A:
53.1		 6fbnB-3so4A:
60.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tsm INDOLE-3-GLYCEROL
PHOSPHATE SYNTHASE

(Brucella
abortus) 		PF00218
(IGPS) 		4 PRO A  99
ASP A  97
SER A 148
PHE A 124
 None
 1.15A 6fbnB-3tsmA:
undetectable		 6fbnB-3tsmA:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v8u TRANSFERRIN
BINDING-PROTEIN B

(Neisseria
meningitidis) 		PF01298
(TbpB_B_D)
PF17483
(TbpB_C)
PF17484
(TbpB_A) 		4 HIS A 143
ASP A 161
PHE A 217
ASP A 221
 None
 0.87A 6fbnB-3v8uA:
undetectable		 6fbnB-3v8uA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vss BETA-FRUCTOFURANOSID
ASE

(Microbacterium
saccharophilum) 		PF02435
(Glyco_hydro_68) 		4 PRO A 442
ASP A 472
SER A 458
PHE A 470
 None
None
FRU  A 601 (-2.9A)
None
 1.15A 6fbnB-3vssA:
undetectable		 6fbnB-3vssA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zu0 NAD NUCLEOTIDASE

(Haemophilus
influenzae) 		PF00149
(Metallophos)
PF02872
(5_nucleotid_C) 		4 ASP A 130
SER A 191
SER A 486
ASP A  94
 A12  A1598 ( 4.4A)
A12  A1598 (-3.8A)
A12  A1598 (-2.8A)
ZN  A1595 (-2.4A)
 0.97A 6fbnB-3zu0A:
undetectable		 6fbnB-3zu0A:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a1o BIFUNCTIONAL PURINE
BIOSYNTHESIS PROTEIN
PURH

(Mycobacterium
tuberculosis) 		PF01808
(AICARFT_IMPCHas)
PF02142
(MGS) 		4 PRO A 154
ASP A 153
SER A 114
ASP A  19
 None
 1.22A 6fbnB-4a1oA:
undetectable		 6fbnB-4a1oA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b56 ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 1

(Mus musculus) 		PF01033
(Somatomedin_B)
PF01223
(Endonuclease_NS)
PF01663
(Phosphodiest) 		4 HIS A 155
ASP A 157
SER A 142
ASP A 151
 None
 1.19A 6fbnB-4b56A:
undetectable		 6fbnB-4b56A:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bkm PYRIDOXAL PHOSPHATE
PHOSPHATASE,
PHOSPHOGLYCOLATE
PHOSPHATASE,
PYRIDOXAL PHOSPHATE
PHOSPHATASE

(Mus musculus) 		PF13242
(Hydrolase_like)
PF13344
(Hydrolase_6) 		4 HIS A 162
PRO A 161
ASP A 160
SER A 127
 None
 1.12A 6fbnB-4bkmA:
undetectable		 6fbnB-4bkmA:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bxs VENOM PROTHROMBIN
ACTIVATOR
PSEUTARIN-C
NON-CATALYTIC
SUBUNIT

(Pseudonaja
textilis) 		PF00754
(F5_F8_type_C)
PF07732
(Cu-oxidase_3) 		4 HIS V 225
SER V 274
SER V 424
ASP V 270
 None
 1.18A 6fbnB-4bxsV:
undetectable		 6fbnB-4bxsV:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c60 OCHRATOXINASE

(Aspergillus
niger) 		PF01979
(Amidohydro_1) 		4 HIS A 307
SER A 304
SER A 414
ASP A 378
 None
 1.18A 6fbnB-4c60A:
undetectable		 6fbnB-4c60A:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c9m CYTOCHROME P450

(Novosphingobium
aromaticivorans) 		PF00067
(p450) 		4 ASP A  99
SER A 251
PHE A 209
ASP A 244
 None
 1.04A 6fbnB-4c9mA:
undetectable		 6fbnB-4c9mA:
23.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dmg PUTATIVE
UNCHARACTERIZED
PROTEIN TTHA1493

(Thermus
thermophilus) 		PF02475
(Met_10) 		4 PRO A 360
ASP A 362
SER A  95
ASP A 200
 None
 0.99A 6fbnB-4dmgA:
undetectable		 6fbnB-4dmgA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e1o HISTIDINE
DECARBOXYLASE

(Homo sapiens) 		PF00282
(Pyridoxal_deC) 		4 HIS A  76
ASP A 463
PHE A 448
ASP A 459
 None
 1.16A 6fbnB-4e1oA:
undetectable		 6fbnB-4e1oA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gfh DNA TOPOISOMERASE 2

(Saccharomyces
cerevisiae) 		PF00204
(DNA_gyraseB)
PF00521
(DNA_topoisoIV)
PF01751
(Toprim)
PF02518
(HATPase_c)
PF16898
(TOPRIM_C) 		4 HIS A 533
ASP A 530
SER A 740
ASP A 687
 None
 1.18A 6fbnB-4gfhA:
undetectable		 6fbnB-4gfhA:
15.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hjw URACIL-5-CARBOXYLATE
DECARBOXYLASE

(Metarhizium
anisopliae) 		PF04909
(Amidohydro_2) 		4 HIS A 251
ASP A 297
PHE A 193
ASP A 323
 None
None
None
ZN  A 401 (-2.8A)
 1.12A 6fbnB-4hjwA:
undetectable		 6fbnB-4hjwA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hpv S-ADENOSYLMETHIONINE
SYNTHASE

(Sulfolobus
solfataricus) 		PF01941
(AdoMet_Synthase) 		5 HIS A  29
PRO A  30
ASP A 199
LYS A 201
ASP A 282
 None
 0.84A 6fbnB-4hpvA:
25.1		 6fbnB-4hpvA:
25.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hw6 HYPOTHETICAL
PROTEIN, IPT/TIG
DOMAIN PROTEIN

(Bacteroides
ovatus) 		PF01833
(TIG) 		4 PRO A 180
ASP A 179
SER A 248
PHE A 250
 None
 1.02A 6fbnB-4hw6A:
undetectable		 6fbnB-4hw6A:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4igm 2-AMINO-3-CARBOXYMUC
ONATE-6-SEMIALDEHYDE
DECARBOXYLASE

(Homo sapiens) 		PF04909
(Amidohydro_2) 		4 HIS A 224
ASP A 265
PHE A 172
ASP A 291
 None
None
None
ZN  A 401 (-3.0A)
 0.94A 6fbnB-4igmA:
undetectable		 6fbnB-4igmA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l4q S-ADENOSYLMETHIONINE
SYNTHASE

(Thermococcus
kodakarensis) 		PF01941
(AdoMet_Synthase) 		4 HIS A  33
PRO A  34
ASP A 201
ASP A 283
 None
 0.84A 6fbnB-4l4qA:
25.4		 6fbnB-4l4qA:
25.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l4q S-ADENOSYLMETHIONINE
SYNTHASE

(Thermococcus
kodakarensis) 		PF01941
(AdoMet_Synthase) 		4 HIS A  33
PRO A  34
ASP A 201
LYS A 203
 None
 0.61A 6fbnB-4l4qA:
25.4		 6fbnB-4l4qA:
25.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l9m RAS GUANYL-RELEASING
PROTEIN 1

(Homo sapiens) 		PF00130
(C1_1)
PF00617
(RasGEF)
PF00618
(RasGEF_N)
PF13405
(EF-hand_6) 		4 HIS A 411
SER A 416
SER A 501
ASP A 408
 None
 1.18A 6fbnB-4l9mA:
undetectable		 6fbnB-4l9mA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lan URACIL-5-CARBOXYLATE
DECARBOXYLASE

(Cordyceps
militaris) 		PF04909
(Amidohydro_2) 		4 HIS A 251
ASP A 297
PHE A 193
ASP A 323
 None
None
None
ZN  A 401 (-3.4A)
 1.19A 6fbnB-4lanA:
undetectable		 6fbnB-4lanA:
22.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4le5 S-ADENOSYLMETHIONINE
SYNTHETASE

(Campylobacter
jejuni) 		PF00438
(S-AdoMet_synt_N)
PF02772
(S-AdoMet_synt_M)
PF02773
(S-AdoMet_synt_C) 		6 HIS A  13
PRO A  14
ASP A 168
LYS A 170
SER A 197
ASP A 250
 None
 0.71A 6fbnB-4le5A:
46.0		 6fbnB-4le5A:
38.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nz0 GENOME POLYPROTEIN

(Cardiovirus A) 		PF00680
(RdRP_1) 		4 HIS A 425
PRO A 393
PHE A 459
ASP A 215
 None
 1.19A 6fbnB-4nz0A:
undetectable		 6fbnB-4nz0A:
21.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4odj S-ADENOSYLMETHIONINE
SYNTHASE

(Cryptosporidium
hominis) 		PF00438
(S-AdoMet_synt_N)
PF02772
(S-AdoMet_synt_M)
PF02773
(S-AdoMet_synt_C) 		8 HIS A  34
PRO A  35
ASP A 187
LYS A 189
SER A 214
SER A 255
PHE A 258
ASP A 266
 SAM  A 500 ( 3.8A)
SAM  A 500 (-4.3A)
SAM  A 500 (-2.8A)
3PO  A 501 ( 2.7A)
SAM  A 500 ( 4.0A)
SAM  A 500 (-2.7A)
SAM  A 500 (-3.5A)
SAM  A 500 (-3.3A)
 0.24A 6fbnB-4odjA:
52.0		 6fbnB-4odjA:
56.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oua LATENT FORM OF PPO4
TYROSINASE

(Agaricus
bisporus) 		PF00264
(Tyrosinase) 		4 PRO B 176
ASP B 175
SER B  49
PHE B  51
 None
 1.21A 6fbnB-4ouaB:
undetectable		 6fbnB-4ouaB:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oua PROTEOLYTICALLY
ACTIVATED FORM OF
PPO4 TYROSINASE

(Agaricus
bisporus) 		PF00264
(Tyrosinase) 		4 PRO A 176
ASP A 175
SER A  49
PHE A  51
 None
 1.20A 6fbnB-4ouaA:
undetectable		 6fbnB-4ouaA:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4s17 GLUTAMINE SYNTHETASE

(Bifidobacterium
adolescentis) 		PF00120
(Gln-synt_C)
PF03951
(Gln-synt_N) 		4 HIS A 238
ASP A 241
PHE A 378
ASP A  75
 None
 1.09A 6fbnB-4s17A:
undetectable		 6fbnB-4s17A:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uzj NOTUM

(Drosophila
melanogaster) 		PF03283
(PAE) 		4 PRO A 616
SER A 270
PHE A 333
ASP A 391
 None
 1.18A 6fbnB-4uzjA:
undetectable		 6fbnB-4uzjA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v39 SIALYLTRANSFERASE

(Pasteurella
dagmatis) 		PF11477
(PM0188) 		4 HIS A   7
ASP A   6
SER A 309
ASP A 114
 None
 0.91A 6fbnB-4v39A:
undetectable		 6fbnB-4v39A:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wk0 INTEGRIN BETA-1

(Homo sapiens) 		PF00362
(Integrin_beta)
PF17205
(PSI_integrin) 		4 ASP B 295
SER B 291
SER B 198
ASP B 267
 None
 1.19A 6fbnB-4wk0B:
undetectable		 6fbnB-4wk0B:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xdt FAD:PROTEIN FMN
TRANSFERASE

(Treponema
pallidum) 		PF02424
(ApbE) 		4 HIS A 220
ASP A 218
PHE A 336
ASP A 271
 None
 0.87A 6fbnB-4xdtA:
undetectable		 6fbnB-4xdtA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xky DIHYDRODIPICOLINATE
SYNTHASE

(Bacteroides
thetaiotaomicron) 		PF00701
(DHDPS) 		4 LYS A   2
SER A 187
PHE A 134
ASP A 101
 MHO  A   1 ( 3.0A)
None
None
MHO  A   1 ( 3.2A)
 1.18A 6fbnB-4xkyA:
undetectable		 6fbnB-4xkyA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yhj G PROTEIN-COUPLED
RECEPTOR KINASE 4

(Homo sapiens) 		PF00069
(Pkinase)
PF00615
(RGS) 		4 HIS A  47
SER A 169
SER A 165
PHE A 168
 None
 1.12A 6fbnB-4yhjA:
undetectable		 6fbnB-4yhjA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zpd RNA-DIRECTED RNA
POLYMERASE

(Enterovirus B) 		PF00680
(RdRP_1) 		4 HIS A 424
PRO A 391
PHE A 462
ASP A 215
 None
 1.21A 6fbnB-4zpdA:
undetectable		 6fbnB-4zpdA:
23.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5a1i S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2

(Homo sapiens) 		PF00438
(S-AdoMet_synt_N)
PF02772
(S-AdoMet_synt_M)
PF02773
(S-AdoMet_synt_C) 		8 HIS A  29
PRO A  30
ASP A 179
LYS A 181
SER A 206
SER A 247
PHE A 250
ASP A 258
 SAM  A 405 ( 3.6A)
SAM  A 405 (-4.0A)
ADN  A 407 (-2.8A)
PPK  A 400 ( 2.6A)
ADN  A 407 ( 3.9A)
ADN  A 407 (-2.7A)
SAM  A 405 (-3.4A)
K  A 403 ( 3.0A)
 0.23A 6fbnB-5a1iA:
54.6		 6fbnB-5a1iA:
99.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5chc DMSO REDUCTASE
FAMILY TYPE II
ENZYME,
MOLYBDOPTERIN
SUBUNIT

(Azospira oryzae) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding) 		4 HIS A 456
PRO A 172
SER A 700
PHE A 711
 None
 0.93A 6fbnB-5chcA:
undetectable		 6fbnB-5chcA:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cz3 M64R

(Myxoma virus) 		PF03287
(Pox_C7_F8A) 		4 HIS A  22
ASP A  10
SER A  19
PHE A  12
 None
 1.10A 6fbnB-5cz3A:
undetectable		 6fbnB-5cz3A:
20.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5h9u S-ADENOSYLMETHIONINE
SYNTHASE

(Thermus
thermophilus) 		no annotation 7 HIS C  16
PRO C  17
ASP C 175
SER C 198
SER C 240
PHE C 243
ASP C 251
 None
 0.77A 6fbnB-5h9uC:
51.2		 6fbnB-5h9uC:
50.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5h9u S-ADENOSYLMETHIONINE
SYNTHASE

(Thermus
thermophilus) 		no annotation 5 HIS C  16
PRO C  17
LYS C 177
SER C 198
ASP C 251
 None
 1.12A 6fbnB-5h9uC:
51.2		 6fbnB-5h9uC:
50.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jvk UNCHARACTERIZED
PROTEIN

(Bacteroides
cellulosilyticus) 		no annotation 4 HIS A 137
SER A 188
PHE A 184
ASP A 162
 GOL  A 654 (-4.3A)
None
None
GOL  A 654 (-2.9A)
 1.17A 6fbnB-5jvkA:
undetectable		 6fbnB-5jvkA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lc2 PROTEIN FAM3C

(Homo sapiens) 		PF15711
(ILEI) 		4 HIS A  68
PRO A  65
SER A 194
PHE A 196
 None
 1.12A 6fbnB-5lc2A:
undetectable		 6fbnB-5lc2A:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oj7 NAD-DEPENDENT
PROTEIN DEACYLASE

(Xenopus
tropicalis) 		no annotation 4 HIS A 160
SER A 157
SER A 244
PHE A 241
 GOL  A 407 ( 3.5A)
EDO  A 406 (-2.6A)
EDO  A 406 (-3.3A)
EDO  A 405 ( 3.7A)
 1.17A 6fbnB-5oj7A:
undetectable		 6fbnB-5oj7A:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5t8t S-ADENOSYLMETHIONINE
SYNTHASE

(Neisseria
gonorrhoeae) 		PF00438
(S-AdoMet_synt_N)
PF02772
(S-AdoMet_synt_M)
PF02773
(S-AdoMet_synt_C) 		4 ASP A 166
LYS A 168
SER A 191
PHE A 235
 None
 0.61A 6fbnB-5t8tA:
50.3		 6fbnB-5t8tA:
55.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5t8t S-ADENOSYLMETHIONINE
SYNTHASE

(Neisseria
gonorrhoeae) 		PF00438
(S-AdoMet_synt_N)
PF02772
(S-AdoMet_synt_M)
PF02773
(S-AdoMet_synt_C) 		5 HIS A  15
PRO A  16
ASP A 166
PHE A 235
ASP A 243
 None
 0.54A 6fbnB-5t8tA:
50.3		 6fbnB-5t8tA:
55.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5t8t S-ADENOSYLMETHIONINE
SYNTHASE

(Neisseria
gonorrhoeae) 		PF00438
(S-AdoMet_synt_N)
PF02772
(S-AdoMet_synt_M)
PF02773
(S-AdoMet_synt_C) 		5 HIS A  15
PRO A  16
ASP A 166
SER A 191
PHE A 235
 None
 0.31A 6fbnB-5t8tA:
50.3		 6fbnB-5t8tA:
55.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t98 GLYCOSIDE HYDROLASE

(Bacteroides
uniformis) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF16355
(DUF4982) 		4 PRO A 559
ASP A 560
SER A 703
ASP A 549
 None
 0.99A 6fbnB-5t98A:
undetectable		 6fbnB-5t98A:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tdx ANCESTRAL
HYDROXYNITRILE LYASE
1

(synthetic
construct) 		no annotation 4 PRO A 212
LYS A 208
SER A 240
ASP A 205
 None
 0.91A 6fbnB-5tdxA:
undetectable		 6fbnB-5tdxA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wea PROTEIN ARGONAUTE-2

(Homo sapiens) 		no annotation 4 HIS A 807
SER A 798
SER A 763
ASP A 597
 None
A  B   5 ( 4.5A)
None
None
 1.06A 6fbnB-5weaA:
undetectable		 6fbnB-5weaA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z0u NEOPULLULANASE 1

(Thermoactinomyces
vulgaris) 		no annotation 4 ASP A 141
SER A 522
SER A 171
ASP A 151
 None
None
None
CA  A 702 (-3.2A)
 0.97A 6fbnB-5z0uA:
undetectable		 6fbnB-5z0uA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z0u NEOPULLULANASE 1

(Thermoactinomyces
vulgaris) 		no annotation 4 HIS A 630
SER A 425
PHE A 476
ASP A 483
 None
 1.12A 6fbnB-5z0uA:
undetectable		 6fbnB-5z0uA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c87 RAB GDP DISSOCIATION
INHIBITOR ALPHA

(Naegleria
fowleri) 		no annotation 4 HIS A 188
ASP A 334
SER A 415
ASP A 195
 None
 1.18A 6fbnB-6c87A:
undetectable		 6fbnB-6c87A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6etz BETA-GALACTOSIDASE

(Arthrobacter
sp. 32cB) 		no annotation 4 HIS A 372
PRO A 373
PHE A 215
ASP A 150
 None
 1.22A 6fbnB-6etzA:
undetectable		 6fbnB-6etzA:
undetectable