SIMILAR PATTERNS OF AMINO ACIDS FOR 6F8C_A_STRA502

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a0c XYLOSE ISOMERASE

(Thermoanaerobacterium
thermosulfurigenes) 		PF01261
(AP_endonuc_2) 		4 ALA A 141
GLY A 189
ILE A 230
PHE A 262
 None
 0.84A 6f8cA-1a0cA:
0.0		 6f8cA-1a0cA:
11.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a0e XYLOSE ISOMERASE

(Thermotoga
neapolitana) 		PF01261
(AP_endonuc_2) 		4 ALA A 141
GLY A 189
ILE A 230
PHE A 262
 None
 0.89A 6f8cA-1a0eA:
1.5		 6f8cA-1a0eA:
14.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1aye PROCARBOXYPEPTIDASE
A2

(Homo sapiens) 		PF00246
(Peptidase_M14)
PF02244
(Propep_M14) 		4 ALA A 268
GLY A  67
THR A 111
ILE A 179
 None
 0.90A 6f8cA-1ayeA:
0.0		 6f8cA-1ayeA:
11.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bmt METHIONINE SYNTHASE

(Escherichia
coli) 		PF02310
(B12-binding)
PF02607
(B12-binding_2) 		4 ALA A 752
GLY A 834
THR A 837
ILE A 846
 None
COB  A 122 (-3.6A)
None
None
 0.89A 6f8cA-1bmtA:
0.0		 6f8cA-1bmtA:
14.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dbv GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE

(Geobacillus
stearothermophilus) 		PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C) 		4 ALA O 272
SER O 289
GLY O 316
THR O 315
 None
 0.88A 6f8cA-1dbvO:
0.0		 6f8cA-1dbvO:
13.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dtd CARBOXYPEPTIDASE A2

(Homo sapiens) 		PF00246
(Peptidase_M14) 		4 ALA A 624
GLY A 422
THR A 466
ILE A 535
 None
 0.91A 6f8cA-1dtdA:
0.0		 6f8cA-1dtdA:
13.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e4o MALTODEXTRIN
PHOSPHORYLASE

(Escherichia
coli) 		PF00343
(Phosphorylase) 		4 ALA A 332
SER A 337
GLY A 413
ILE A 371
 None
 0.76A 6f8cA-1e4oA:
0.0		 6f8cA-1e4oA:
8.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gvf TAGATOSE-BISPHOSPHAT
E ALDOLASE AGAY

(Escherichia
coli) 		PF01116
(F_bP_aldolase) 		4 SER A 106
GLY A 136
THR A 155
ILE A 197
 None
 0.86A 6f8cA-1gvfA:
0.0		 6f8cA-1gvfA:
12.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h0h FORMATE
DEHYDROGENASE
SUBUNIT ALPHA

(Desulfovibrio
gigas) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF04879
(Molybdop_Fe4S4) 		4 ALA A 410
GLY A  57
THR A  60
ILE A 576
 None
SF4  A1010 (-3.5A)
None
None
 0.91A 6f8cA-1h0hA:
0.0		 6f8cA-1h0hA:
6.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h74 HOMOSERINE KINASE

(Methanocaldococcus
jannaschii) 		PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C) 		4 ALA A 126
SER A  98
GLY A  96
THR A  14
 None
ADP  A 400 (-3.9A)
ADP  A 400 ( 4.0A)
None
 0.85A 6f8cA-1h74A:
undetectable		 6f8cA-1h74A:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ibv HISTIDINE
DECARBOXYLASE ALPHA
CHAIN

(Lactobacillus
sp. 30A) 		PF02329
(HDC) 		4 ALA B 104
SER B  98
GLY B  92
ILE B 182
 None
 0.87A 6f8cA-1ibvB:
undetectable		 6f8cA-1ibvB:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ii0 ARSENICAL
PUMP-DRIVING ATPASE

(Escherichia
coli) 		PF02374
(ArsA_ATPase) 		4 SER A 560
GLY A 523
ILE A 330
PHE A 443
 None
 0.70A 6f8cA-1ii0A:
undetectable		 6f8cA-1ii0A:
10.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j2b ARCHAEOSINE
TRNA-GUANINE
TRANSGLYCOSYLASE

(Pyrococcus
horikoshii) 		PF01472
(PUA)
PF01702
(TGT)
PF14809
(TGT_C1)
PF14810
(TGT_C2) 		4 ALA A 480
GLY A 487
THR A 414
PHE A 395
 None
 0.85A 6f8cA-1j2bA:
undetectable		 6f8cA-1j2bA:
8.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jax CONSERVED
HYPOTHETICAL PROTEIN

(Archaeoglobus
fulgidus) 		PF03807
(F420_oxidored) 		4 ALA A  41
SER A  31
GLY A   7
THR A  71
 None
 0.87A 6f8cA-1jaxA:
undetectable		 6f8cA-1jaxA:
15.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jr7 HYPOTHETICAL 37.4
KDA PROTEIN IN
ILEY-GABD INTERGENIC
REGION

(Escherichia
coli) 		PF08943
(CsiD) 		5 ALA A 136
SER A 125
GLY A 312
THR A 170
PHE A 247
 None
 1.47A 6f8cA-1jr7A:
undetectable		 6f8cA-1jr7A:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jsc ACETOHYDROXY-ACID
SYNTHASE

(Saccharomyces
cerevisiae) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		4 ALA A 563
GLY A 528
THR A 494
ILE A 492
 None
 0.90A 6f8cA-1jscA:
undetectable		 6f8cA-1jscA:
10.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kfu M-CALPAIN LARGE
SUBUNIT

(Homo sapiens) 		PF00648
(Peptidase_C2)
PF01067
(Calpain_III)
PF13833
(EF-hand_8) 		4 ALA L 231
GLY L 210
THR L 208
ILE L 120
 None
 0.75A 6f8cA-1kfuL:
undetectable		 6f8cA-1kfuL:
7.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nvp TRANSCRIPTION
INITIATION FACTOR
IIA BETA CHAIN
TRANSCRIPTION
INITIATION FACTOR
IIA GAMMA CHAIN

(Homo sapiens) 		PF02268
(TFIIA_gamma_N)
PF02751
(TFIIA_gamma_C)
PF03153
(TFIIA) 		4 SER C 368
GLY C 356
ILE D  95
PHE D  74
 None
 0.85A 6f8cA-1nvpC:
undetectable		 6f8cA-1nvpC:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pc0 HYPOTHETICAL PROTEIN
AF1917

(Archaeoglobus
fulgidus) 		PF01868
(UPF0086) 		4 SER A  29
GLY A  32
THR A  49
ILE A  47
 None
 0.84A 6f8cA-1pc0A:
undetectable		 6f8cA-1pc0A:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qi9 PROTEIN (VANADIUM
BROMOPEROXIDASE)

(Ascophyllum
nodosum) 		no annotation 4 ALA A 107
GLY A 417
THR A 420
ILE A 501
 None
VO4  A 600 (-3.8A)
None
None
 0.83A 6f8cA-1qi9A:
0.2		 6f8cA-1qi9A:
12.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qqe VESICULAR TRANSPORT
PROTEIN SEC17

(Saccharomyces
cerevisiae) 		PF14938
(SNAP) 		4 ALA A  63
GLY A  71
ILE A 106
PHE A 107
 None
 0.89A 6f8cA-1qqeA:
undetectable		 6f8cA-1qqeA:
12.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qxp MU-LIKE CALPAIN

(Bos taurus;
Rattus
norvegicus) 		PF00648
(Peptidase_C2)
PF01067
(Calpain_III)
PF13833
(EF-hand_8) 		4 ALA A 231
GLY A 210
THR A 208
ILE A 120
 None
 0.70A 6f8cA-1qxpA:
undetectable		 6f8cA-1qxpA:
6.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r24 PROTEIN (IGG3-KAPPA
ANTIBODY (HEAVY
CHAIN))

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 ALA B  24
SER B  30
GLY B  54
ILE B  70
 None
 0.83A 6f8cA-1r24B:
undetectable		 6f8cA-1r24B:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s4e GALACTOKINASE

(Pyrococcus
furiosus) 		PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C)
PF10509
(GalKase_gal_bdg) 		4 ALA A 154
SER A 105
GLY A 103
ILE A 312
 None
MG  A 600 (-4.0A)
ADP  A 400 ( 4.1A)
None
 0.86A 6f8cA-1s4eA:
undetectable		 6f8cA-1s4eA:
12.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uxt GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(NADP+)

(Thermoproteus
tenax) 		PF00171
(Aldedh) 		4 ALA A 111
SER A 291
GLY A 294
ILE A 340
 None
 0.86A 6f8cA-1uxtA:
undetectable		 6f8cA-1uxtA:
10.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vj0 ALCOHOL
DEHYDROGENASE,
ZINC-CONTAINING

(Thermotoga
maritima) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 ALA A 262
SER A 167
GLY A 168
PHE A 182
 None
 0.80A 6f8cA-1vj0A:
undetectable		 6f8cA-1vj0A:
11.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vkz PHOSPHORIBOSYLAMINE-
-GLYCINE LIGASE

(Thermotoga
maritima) 		PF01071
(GARS_A)
PF02843
(GARS_C)
PF02844
(GARS_N) 		4 GLY A 279
THR A 283
ILE A  18
PHE A  22
 None
 0.88A 6f8cA-1vkzA:
undetectable		 6f8cA-1vkzA:
11.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vp4 AMINOTRANSFERASE,
PUTATIVE

(Thermotoga
maritima) 		PF00155
(Aminotran_1_2) 		5 ALA A 134
GLY A 105
THR A 103
ILE A 269
PHE A 265
 None
PLP  A 501 (-3.2A)
None
None
FMT  A 622 ( 4.4A)
 1.06A 6f8cA-1vp4A:
undetectable		 6f8cA-1vp4A:
11.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vp4 AMINOTRANSFERASE,
PUTATIVE

(Thermotoga
maritima) 		PF00155
(Aminotran_1_2) 		5 ALA A 137
GLY A 105
THR A 103
ILE A 269
PHE A 265
 None
PLP  A 501 (-3.2A)
None
None
FMT  A 622 ( 4.4A)
 1.21A 6f8cA-1vp4A:
undetectable		 6f8cA-1vp4A:
11.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xe7 HYPOTHETICAL 22.5
KDA PROTEIN IN
TUB1-CPR3 INTERGENIC
REGION

(Saccharomyces
cerevisiae) 		PF06172
(Cupin_5) 		4 GLY A 170
THR A  80
ILE A  82
PHE A  48
 None
ACY  A 307 (-3.5A)
ACY  A 307 ( 3.9A)
GUN  A 210 (-4.5A)
 0.83A 6f8cA-1xe7A:
undetectable		 6f8cA-1xe7A:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zzh CYTOCHROME C
PEROXIDASE

(Rhodobacter
capsulatus) 		PF00034
(Cytochrom_C)
PF03150
(CCP_MauG) 		4 ALA A 250
GLY A 284
ILE A 295
PHE A 298
 HEC  A 803 (-3.8A)
HEC  A 803 ( 4.4A)
HEC  A 803 ( 4.4A)
None
 0.78A 6f8cA-1zzhA:
undetectable		 6f8cA-1zzhA:
15.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a22 VACUOLAR PROTEIN
SORTING 29

(Cryptosporidium
parvum) 		PF12850
(Metallophos_2) 		4 ALA A 161
GLY A 129
THR A  43
ILE A  12
 None
 0.89A 6f8cA-2a22A:
undetectable		 6f8cA-2a22A:
15.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bac PUTATIVE
AMINOOXIDASE

(Cutibacterium
acnes) 		PF01593
(Amino_oxidase) 		4 ALA A 318
GLY A  83
THR A 200
ILE A  61
 None
None
None
FAD  A 500 (-4.5A)
 0.85A 6f8cA-2bacA:
undetectable		 6f8cA-2bacA:
12.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bpq ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE

(Mycobacterium
tuberculosis) 		PF00591
(Glycos_transf_3)
PF02885
(Glycos_trans_3N) 		4 ALA A 122
GLY A 217
ILE A 261
PHE A 274
 None
None
None
GOL  A1370 (-4.2A)
 0.88A 6f8cA-2bpqA:
undetectable		 6f8cA-2bpqA:
12.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c0n A197

(Sulfolobus
turreted
icosahedral
virus 1) 		no annotation 4 GLY A 119
THR A 121
ILE A 123
PHE A 127
 None
 0.76A 6f8cA-2c0nA:
undetectable		 6f8cA-2c0nA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c81 GLUTAMINE-2-DEOXY-SC
YLLO-INOSOSE
AMINOTRANSFERASE

(Bacillus
circulans) 		PF01041
(DegT_DnrJ_EryC1) 		4 ALA A  94
SER A 187
GLY A 200
THR A  63
 PMP  A1416 ( 3.7A)
PMP  A1416 (-2.5A)
None
None
 0.75A 6f8cA-2c81A:
undetectable		 6f8cA-2c81A:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cir HEXOSE-6-PHOSPHATE
MUTAROTASE

(Saccharomyces
cerevisiae) 		PF01263
(Aldose_epim) 		4 SER A 210
THR A 235
ILE A 263
PHE A 162
 None
 0.90A 6f8cA-2cirA:
undetectable		 6f8cA-2cirA:
14.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d0o DIOL
DEHYDRATASE-REACTIVA
TING FACTOR LARGE
SUBUNIT

(Klebsiella
oxytoca) 		PF08841
(DDR) 		4 ALA A  53
SER A  13
GLY A  10
ILE A 373
 None
ADP  A1001 (-2.6A)
ADP  A1001 (-3.3A)
None
 0.88A 6f8cA-2d0oA:
undetectable		 6f8cA-2d0oA:
8.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dr3 UPF0273 PROTEIN
PH0284

(Pyrococcus
horikoshii) 		PF06745
(ATPase) 		4 ALA A 129
GLY A 161
ILE A 117
PHE A 116
 None
 0.90A 6f8cA-2dr3A:
undetectable		 6f8cA-2dr3A:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dw6 BLL6730 PROTEIN

(Bradyrhizobium
japonicum) 		PF13378
(MR_MLE_C) 		4 ALA A 388
GLY A  51
THR A 115
ILE A  64
 None
 0.86A 6f8cA-2dw6A:
undetectable		 6f8cA-2dw6A:
10.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f43 ATP SYNTHASE ALPHA
CHAIN, MITOCHONDRIAL

(Rattus
norvegicus) 		PF00006
(ATP-synt_ab)
PF00306
(ATP-synt_ab_C)
PF02874
(ATP-synt_ab_N) 		4 ALA A 402
GLY A 421
THR A 425
ILE A 361
 None
 0.80A 6f8cA-2f43A:
undetectable		 6f8cA-2f43A:
8.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hro PHOSPHOENOLPYRUVATE-
PROTEIN
PHOSPHOTRANSFERASE

(Staphylococcus
carnosus) 		PF00391
(PEP-utilizers)
PF02896
(PEP-utilizers_C)
PF05524
(PEP-utilisers_N) 		4 ALA A 440
SER A 435
THR A 461
ILE A 482
 None
 0.79A 6f8cA-2hroA:
undetectable		 6f8cA-2hroA:
10.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i0z NAD(FAD)-UTILIZING
DEHYDROGENASES

(Bacillus cereus) 		PF03486
(HI0933_like) 		4 ALA A  17
GLY A 164
ILE A 392
PHE A  70
 None
FAD  A 501 (-3.3A)
None
None
 0.82A 6f8cA-2i0zA:
undetectable		 6f8cA-2i0zA:
11.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i2x METHYLTRANSFERASE 1

(Methanosarcina
barkeri) 		PF12176
(MtaB) 		5 ALA A 221
SER A 187
GLY A 192
ILE A 199
PHE A 146
 B13  B 500 ( 3.8A)
None
None
None
None
 1.49A 6f8cA-2i2xA:
undetectable		 6f8cA-2i2xA:
11.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ixs SDAI RESTRICTION
ENDONUCLEASE

(Streptomyces
diastaticus) 		PF06616
(BsuBI_PstI_RE) 		4 ALA A  17
GLY A  44
ILE A  64
PHE A  84
 None
 0.89A 6f8cA-2ixsA:
undetectable		 6f8cA-2ixsA:
14.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mqa MINOR AMPULLATE
FIBROIN 1

(Nephila
antipodiana) 		PF12042
(RP1-2) 		4 SER A  81
GLY A  84
ILE A  38
PHE A  34
 None
 0.80A 6f8cA-2mqaA:
undetectable		 6f8cA-2mqaA:
16.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oae DIPEPTIDYL PEPTIDASE
4

(Rattus
norvegicus) 		PF00326
(Peptidase_S9)
PF00930
(DPPIV_N) 		5 ALA A 163
SER A 156
GLY A 218
ILE A 268
PHE A 266
 None
 1.47A 6f8cA-2oaeA:
undetectable		 6f8cA-2oaeA:
7.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pgw MUCONATE
CYCLOISOMERASE

(Sinorhizobium
meliloti) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 GLY A 304
THR A 307
ILE A 326
PHE A 140
 None
 0.90A 6f8cA-2pgwA:
undetectable		 6f8cA-2pgwA:
12.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2po3 4-DEHYDRASE

(Streptomyces
venezuelae) 		PF01041
(DegT_DnrJ_EryC1) 		5 ALA A1172
SER A1195
GLY A1208
THR A1073
ILE A1221
 None
T4K  A1500 ( 2.8A)
None
None
None
 1.20A 6f8cA-2po3A:
0.0		 6f8cA-2po3A:
11.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qez ETHANOLAMINE
AMMONIA-LYASE HEAVY
CHAIN

(Listeria
monocytogenes) 		PF06751
(EutB) 		4 ALA A 449
GLY A 184
ILE A 190
PHE A 209
 None
 0.80A 6f8cA-2qezA:
undetectable		 6f8cA-2qezA:
10.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qj8 MLR6093 PROTEIN

(Mesorhizobium
japonicum) 		PF04952
(AstE_AspA) 		4 ALA A  90
GLY A  51
THR A  50
ILE A 125
 None
 0.89A 6f8cA-2qj8A:
undetectable		 6f8cA-2qj8A:
14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qxl HEAT SHOCK PROTEIN
HOMOLOG SSE1

(Saccharomyces
cerevisiae) 		PF00012
(HSP70) 		4 ALA A 178
GLY A 342
THR A 345
PHE A 358
 None
ATP  A1002 (-3.3A)
None
None
 0.86A 6f8cA-2qxlA:
2.4		 6f8cA-2qxlA:
8.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r4f 3-HYDROXY-3-METHYLGL
UTARYL-COENZYME A
REDUCTASE

(Homo sapiens) 		PF00368
(HMG-CoA_red) 		4 ALA A 579
GLY A 569
THR A 566
ILE A 756
 None
 0.90A 6f8cA-2r4fA:
undetectable		 6f8cA-2r4fA:
11.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r98 PUTATIVE
ACETYLGLUTAMATE
SYNTHASE

(Neisseria
gonorrhoeae) 		PF00583
(Acetyltransf_1)
PF00696
(AA_kinase) 		4 ALA A 234
GLY A 210
THR A 279
ILE A 281
 None
 0.75A 6f8cA-2r98A:
undetectable		 6f8cA-2r98A:
12.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uvj ABC TYPE PERIPLASMIC
SUGAR-BINDING
PROTEIN

(Yersinia
enterocolitica) 		PF13416
(SBP_bac_8) 		4 ALA A 284
GLY A 265
THR A 266
ILE A 273
 None
 0.81A 6f8cA-2uvjA:
0.6		 6f8cA-2uvjA:
12.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vef DIHYDROPTEROATE
SYNTHASE

(Streptococcus
pneumoniae) 		PF00809
(Pterin_bind) 		4 SER A 235
GLY A 233
ILE A 112
PHE A 154
 None
 0.89A 6f8cA-2vefA:
undetectable		 6f8cA-2vefA:
14.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vsq SURFACTIN SYNTHETASE
SUBUNIT 3

(Bacillus
subtilis) 		PF00501
(AMP-binding)
PF00550
(PP-binding)
PF00668
(Condensation)
PF00975
(Thioesterase)
PF13193
(AMP-binding_C) 		4 ALA A 392
SER A 234
ILE A 429
PHE A 314
 None
 0.91A 6f8cA-2vsqA:
undetectable		 6f8cA-2vsqA:
5.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wtk STE20-RELATED KINASE
ADAPTER PROTEIN
ALPHA

(Homo sapiens) 		PF00069
(Pkinase) 		4 ALA B 370
GLY B 266
THR B 268
ILE B 201
 None
 0.87A 6f8cA-2wtkB:
undetectable		 6f8cA-2wtkB:
11.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x27 OUTER MEMBRANE
PROTEIN OPRG

(Pseudomonas
aeruginosa) 		PF03922
(OmpW) 		4 SER X 184
GLY X 182
THR X 191
ILE X  28
 None
 0.89A 6f8cA-2x27X:
undetectable		 6f8cA-2x27X:
16.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yhe SEC-ALKYL SULFATASE

(Pseudomonas sp.
DSM 6611) 		PF00753
(Lactamase_B)
PF14863
(Alkyl_sulf_dimr)
PF14864
(Alkyl_sulf_C) 		4 ALA A 546
GLY A 186
THR A 149
ILE A 192
 None
 0.89A 6f8cA-2yheA:
undetectable		 6f8cA-2yheA:
8.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z1q ACYL-COA
DEHYDROGENASE

(Thermus
thermophilus) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		4 SER A 107
GLY A 111
THR A 114
ILE A  77
 None
 0.75A 6f8cA-2z1qA:
0.8		 6f8cA-2z1qA:
9.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z67 O-PHOSPHOSERYL-TRNA(
SEC) SELENIUM
TRANSFERASE

(Methanococcus
maripaludis) 		PF05889
(SepSecS) 		5 ALA A 172
SER A 138
GLY A 287
ILE A 300
PHE A 296
 None
PLP  A1001 (-3.3A)
None
None
None
 1.42A 6f8cA-2z67A:
undetectable		 6f8cA-2z67A:
10.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z67 O-PHOSPHOSERYL-TRNA(
SEC) SELENIUM
TRANSFERASE

(Methanococcus
maripaludis) 		PF05889
(SepSecS) 		5 SER A 275
GLY A 287
THR A 135
ILE A 300
PHE A 296
 None
 1.43A 6f8cA-2z67A:
undetectable		 6f8cA-2z67A:
10.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aqu AT4G19810

(Arabidopsis
thaliana) 		PF00704
(Glyco_hydro_18) 		5 ALA A 251
SER A 192
GLY A 188
ILE A 298
PHE A 272
 None
 1.26A 6f8cA-3aquA:
undetectable		 6f8cA-3aquA:
13.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cp2 TRNA URIDINE
5-CARBOXYMETHYLAMINO
METHYL MODIFICATION
ENZYME GIDA

(Escherichia
coli) 		PF01134
(GIDA)
PF13932
(GIDA_assoc) 		4 ALA A 138
GLY A  13
ILE A 371
PHE A 348
 None
 0.79A 6f8cA-3cp2A:
undetectable		 6f8cA-3cp2A:
8.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cwc PUTATIVE GLYCERATE
KINASE 2

(Salmonella
enterica) 		PF02595
(Gly_kinase) 		4 ALA A 250
SER A 111
GLY A 115
ILE A 129
 None
 0.89A 6f8cA-3cwcA:
undetectable		 6f8cA-3cwcA:
12.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e74 ALLANTOINASE

(Escherichia
coli) 		PF01979
(Amidohydro_1) 		4 ALA A  40
GLY A  28
ILE A 426
PHE A 390
 None
 0.82A 6f8cA-3e74A:
undetectable		 6f8cA-3e74A:
10.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g68 PUTATIVE
PHOSPHOSUGAR
ISOMERASE

(Clostridioides
difficile) 		PF01380
(SIS) 		4 SER A 113
GLY A  87
THR A  39
ILE A  71
 None
 0.83A 6f8cA-3g68A:
undetectable		 6f8cA-3g68A:
9.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gay FRUCTOSE-BISPHOSPHAT
E ALDOLASE

(Giardia
intestinalis) 		PF01116
(F_bP_aldolase) 		4 SER A 107
GLY A 137
THR A 153
ILE A 199
 None
 0.80A 6f8cA-3gayA:
undetectable		 6f8cA-3gayA:
11.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ghp CELLULOSOMAL
SCAFFOLDIN ADAPTOR
PROTEIN B

(Acetivibrio
cellulolyticus) 		PF00963
(Cohesin) 		4 ALA A  55
SER A  68
GLY A  87
PHE A 137
 None
 0.90A 6f8cA-3ghpA:
undetectable		 6f8cA-3ghpA:
14.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3grk ENOYL-(ACYL-CARRIER-
PROTEIN) REDUCTASE
(NADH)

(Brucella
melitensis) 		PF13561
(adh_short_C2) 		4 ALA A  35
GLY A 232
ILE A  15
PHE A  41
 None
 0.77A 6f8cA-3grkA:
undetectable		 6f8cA-3grkA:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3him PROBABLE
TRANSCRIPTIONAL
REGULATOR

(Rhodococcus
jostii) 		PF00440
(TetR_N) 		4 ALA A 109
GLY A  33
THR A  37
ILE A  42
 None
 0.84A 6f8cA-3himA:
undetectable		 6f8cA-3himA:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i3a ACYL-[ACYL-CARRIER-P
ROTEIN]--UDP-N-ACETY
LGLUCOSAMINE
O-ACYLTRANSFERASE

(Leptospira
interrogans) 		PF00132
(Hexapep)
PF13720
(Acetyltransf_11) 		4 SER A 102
GLY A  97
ILE A  94
PHE A  88
 None
 0.81A 6f8cA-3i3aA:
undetectable		 6f8cA-3i3aA:
12.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ibj CGMP-DEPENDENT
3',5'-CYCLIC
PHOSPHODIESTERASE

(Homo sapiens) 		PF00233
(PDEase_I)
PF01590
(GAF)
PF13185
(GAF_2) 		4 SER A 260
THR A 257
ILE A 366
PHE A 370
 None
 0.82A 6f8cA-3ibjA:
undetectable		 6f8cA-3ibjA:
9.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ldu PUTATIVE METHYLASE

(Clostridioides
difficile) 		PF01170
(UPF0020)
PF02926
(THUMP) 		4 ALA A 182
GLY A 204
ILE A 257
PHE A 255
 None
GTP  A 383 ( 4.3A)
None
None
 0.91A 6f8cA-3lduA:
1.1		 6f8cA-3lduA:
12.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3loi PUTATIVE
UNCHARACTERIZED
PROTEIN

(Branchiostoma
belcheri) 		PF06172
(Cupin_5) 		4 GLY A 139
THR A  54
ILE A  56
PHE A  31
 None
 0.76A 6f8cA-3loiA:
undetectable		 6f8cA-3loiA:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3msg INTRA-CELLULAR
XYLANASE IXT6

(Geobacillus
stearothermophilus) 		PF00331
(Glyco_hydro_10) 		4 ALA A 211
GLY A 292
ILE A  18
PHE A  12
 None
 0.85A 6f8cA-3msgA:
undetectable		 6f8cA-3msgA:
13.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n23 SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1

(Sus scrofa) 		PF00122
(E1-E2_ATPase)
PF00689
(Cation_ATPase_C)
PF00690
(Cation_ATPase_N)
PF13246
(Cation_ATPase) 		4 ALA A 621
GLY A 611
THR A 686
ILE A 694
 None
PHD  A 369 ( 4.5A)
None
None
 0.75A 6f8cA-3n23A:
0.8		 6f8cA-3n23A:
5.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nom GLUTAMINE
CYCLOTRANSFERASE

(Zymomonas
mobilis) 		PF05096
(Glu_cyclase_2) 		4 SER A 122
GLY A 109
ILE A  92
PHE A  49
 None
 0.90A 6f8cA-3nomA:
undetectable		 6f8cA-3nomA:
13.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ntk MATERNAL PROTEIN
TUDOR

(Drosophila
melanogaster) 		PF00567
(TUDOR) 		4 ALA A2450
GLY A2494
THR A2490
ILE A2487
 None
 0.89A 6f8cA-3ntkA:
undetectable		 6f8cA-3ntkA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nvy XANTHINE
DEHYDROGENASE/OXIDAS
E

(Bos taurus) 		PF00111
(Fer2)
PF01799
(Fer2_2) 		4 ALA A  50
THR A 151
ILE A 156
PHE A 160
 FES  A 602 ( 4.7A)
FES  A 601 ( 4.7A)
None
None
 0.89A 6f8cA-3nvyA:
undetectable		 6f8cA-3nvyA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3org CMCLC

(Cyanidioschyzon
merolae) 		PF00654
(Voltage_CLC) 		4 ALA A 503
GLY A 437
ILE A 483
PHE A 484
 None
 0.70A 6f8cA-3orgA:
2.5		 6f8cA-3orgA:
10.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p2m POSSIBLE HYDROLASE

(Mycobacterium
tuberculosis) 		PF12697
(Abhydrolase_6) 		5 ALA A 183
SER A 154
GLY A 157
ILE A 272
PHE A 298
 None
 1.30A 6f8cA-3p2mA:
undetectable		 6f8cA-3p2mA:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qbm TETR TRANSCRIPTIONAL
REGULATOR

(Chloroflexus
aurantiacus) 		PF00440
(TetR_N)
PF16859
(TetR_C_11) 		4 ALA A  61
GLY A  23
THR A  27
ILE A  32
 None
 0.82A 6f8cA-3qbmA:
undetectable		 6f8cA-3qbmA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r0s ACYL-[ACYL-CARRIER-P
ROTEIN]--UDP-N-ACETY
LGLUCOSAMINE
O-ACYLTRANSFERASE

(Campylobacter
jejuni) 		PF00132
(Hexapep)
PF13720
(Acetyltransf_11) 		4 ALA A  93
GLY A  65
THR A  50
ILE A  52
 None
 0.89A 6f8cA-3r0sA:
undetectable		 6f8cA-3r0sA:
16.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sgz HYDROXYACID OXIDASE
2

(Rattus
norvegicus) 		PF01070
(FMN_dh) 		4 SER A  81
GLY A  87
THR A  91
ILE A  74
 None
 0.84A 6f8cA-3sgzA:
undetectable		 6f8cA-3sgzA:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3teb ENDONUCLEASE/EXONUCL
EASE/PHOSPHATASE

(Leptotrichia
buccalis) 		PF03372
(Exo_endo_phos) 		4 ALA A  36
THR A 196
ILE A 261
PHE A 263
 None
 0.90A 6f8cA-3tebA:
undetectable		 6f8cA-3tebA:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tr1 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE

(Coxiella
burnetii) 		PF00275
(EPSP_synthase) 		4 ALA A 275
GLY A 265
THR A 313
ILE A 305
 None
 0.89A 6f8cA-3tr1A:
undetectable		 6f8cA-3tr1A:
10.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uhj PROBABLE GLYCEROL
DEHYDROGENASE

(Sinorhizobium
meliloti) 		PF00465
(Fe-ADH) 		5 ALA A 182
SER A 141
GLY A 115
THR A 118
ILE A  59
 None
GOL  A 487 (-2.6A)
GOL  A 487 ( 3.8A)
None
None
 1.44A 6f8cA-3uhjA:
undetectable		 6f8cA-3uhjA:
11.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v94 CYCLIC NUCLEOTIDE
SPECIFIC
PHOSPHODIESTERASE

(Trypanosoma
cruzi) 		PF00233
(PDEase_I) 		4 ALA A 446
SER A 474
GLY A 478
THR A 480
 None
 0.83A 6f8cA-3v94A:
undetectable		 6f8cA-3v94A:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a0l CULLIN-4B

(Homo sapiens) 		PF00888
(Cullin)
PF10557
(Cullin_Nedd8) 		5 SER E 282
GLY E 349
THR E 346
ILE E 337
PHE E 332
 None
 1.45A 6f8cA-4a0lE:
undetectable		 6f8cA-4a0lE:
7.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a5q CHI1

(Yersinia
entomophaga) 		PF00704
(Glyco_hydro_18) 		4 ALA A  97
SER A 487
GLY A 378
ILE A 423
 None
 0.82A 6f8cA-4a5qA:
undetectable		 6f8cA-4a5qA:
9.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4axk 1-(5-PHOSPHORIBOSYL)
-5-((5'-PHOSPHORIBOS
YLAMINO)
METHYLIDENEAMINO)IMI
DAZOLE-4-CARBOXAMIDE
ISOMERASE

(Corynebacterium
efficiens) 		PF00977
(His_biosynth) 		4 GLY A 148
THR A 139
ILE A 128
PHE A 166
 None
 0.75A 6f8cA-4axkA:
undetectable		 6f8cA-4axkA:
14.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bzi SEC23P

(Saccharomyces
cerevisiae) 		PF00626
(Gelsolin)
PF04810
(zf-Sec23_Sec24)
PF04811
(Sec23_trunk)
PF04815
(Sec23_helical)
PF08033
(Sec23_BS) 		4 GLY A 718
THR A 714
ILE A 712
PHE A 661
 None
 0.78A 6f8cA-4bziA:
undetectable		 6f8cA-4bziA:
7.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c1o BETA-XYLOSIDASE

(Parageobacillus
thermoglucosidasius) 		PF03512
(Glyco_hydro_52) 		4 ALA A 610
GLY A 534
ILE A 664
PHE A 663
 None
 0.80A 6f8cA-4c1oA:
undetectable		 6f8cA-4c1oA:
7.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4csb VIRULENCE ASSOCIATED
PROTEIN VAPD

(Rhodococcus
hoagii) 		PF05526
(R_equi_Vir) 		4 ALA A 119
SER A 124
GLY A 125
PHE A 104
 None
 0.89A 6f8cA-4csbA:
undetectable		 6f8cA-4csbA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ern TFIIH BASAL
TRANSCRIPTION FACTOR
COMPLEX HELICASE XPB
SUBUNIT

(Homo sapiens) 		PF16203
(ERCC3_RAD25_C) 		4 ALA A 562
GLY A 582
THR A 584
ILE A 592
 None
 0.82A 6f8cA-4ernA:
undetectable		 6f8cA-4ernA:
15.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ev0 TRANSCRIPTION
REGULATOR, CRP
FAMILY

(Thermus
thermophilus) 		PF00027
(cNMP_binding)
PF13545
(HTH_Crp_2) 		4 GLY A  49
THR A  95
ILE A  33
PHE A  34
 None
None
None
CMP  A 301 (-4.4A)
 0.88A 6f8cA-4ev0A:
undetectable		 6f8cA-4ev0A:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fio METHENYLTETRAHYDROME
THANOPTERIN
CYCLOHYDROLASE

(Methanobrevibacter
ruminantium) 		PF02289
(MCH) 		4 ALA A 231
SER A 179
THR A  53
ILE A  82
 None
 0.90A 6f8cA-4fioA:
undetectable		 6f8cA-4fioA:
11.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gi5 QUINONE REDUCTASE

(Klebsiella
pneumoniae) 		PF02525
(Flavodoxin_2) 		4 ALA A  30
SER A   0
THR A  93
ILE A  95
 None
 0.91A 6f8cA-4gi5A:
undetectable		 6f8cA-4gi5A:
15.36