SIMILAR PATTERNS OF AMINO ACIDS FOR 6F88_B_STRB502

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bs0 PROTEIN
(8-AMINO-7-OXONANOAT
E SYNTHASE)

(Escherichia
coli) 		PF00155
(Aminotran_1_2) 		5 LEU A 187
ALA A 185
LEU A 230
SER A 219
ASN A 112
 None
 1.14A 6f88B-1bs0A:
0.0		 6f88B-1bs0A:
11.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g5q EPIDERMIN MODIFYING
ENZYME EPID

(Staphylococcus
epidermidis) 		PF02441
(Flavoprotein) 		4 LEU A 110
LEU A  99
THR A  10
ASN A  85
 None
None
FMN  A 300 (-4.0A)
FMN  A 300 (-3.9A)
 0.95A 6f88B-1g5qA:
0.0		 6f88B-1g5qA:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gng GLYCOGEN SYNTHASE
KINASE-3 BETA

(Homo sapiens) 		PF00069
(Pkinase) 		4 LEU A 332
ALA A 170
SER A 368
ASN A 361
 None
 0.79A 6f88B-1gngA:
undetectable		 6f88B-1gngA:
11.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ijq LOW-DENSITY
LIPOPROTEIN RECEPTOR

(Homo sapiens) 		PF00058
(Ldl_recept_b)
PF14670
(FXa_inhibition) 		4 LEU A 425
ALA A 454
SER A 423
ASN A 543
 None
 0.84A 6f88B-1ijqA:
0.0		 6f88B-1ijqA:
13.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pdu NUCLEAR HORMONE
RECEPTOR HR38

(Drosophila
melanogaster) 		PF00104
(Hormone_recep) 		4 LEU A 446
ALA A 405
LEU A 512
THR A 463
 None
 0.86A 6f88B-1pduA:
0.0		 6f88B-1pduA:
14.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r6b CLPA PROTEIN

(Escherichia
coli) 		PF00004
(AAA)
PF02861
(Clp_N)
PF07724
(AAA_2)
PF10431
(ClpB_D2-small) 		4 LEU X  34
ALA X  40
LEU X  88
SER X   9
 None
 0.95A 6f88B-1r6bX:
0.0		 6f88B-1r6bX:
8.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t5j HYPOTHETICAL PROTEIN
MJ1187

(Methanocaldococcus
jannaschii) 		PF03747
(ADP_ribosyl_GH) 		4 LEU A 257
ALA A 258
LEU A 210
THR A 237
 None
 0.89A 6f88B-1t5jA:
0.0		 6f88B-1t5jA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tkc TRANSKETOLASE

(Saccharomyces
cerevisiae) 		PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		4 LEU A 330
ALA A 433
SER A 147
ASN A  54
 None
 0.98A 6f88B-1tkcA:
undetectable		 6f88B-1tkcA:
7.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u0n PLATELET
GLYCOPROTEIN IB

(Homo sapiens) 		PF01462
(LRRNT)
PF13855
(LRR_8) 		4 LEU D 120
ALA D 119
LEU D 153
ASN D 158
 None
 0.84A 6f88B-1u0nD:
0.0		 6f88B-1u0nD:
13.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vb3 THREONINE SYNTHASE

(Escherichia
coli) 		PF00291
(PALP)
PF14821
(Thr_synth_N) 		4 ALA A 377
SER A 350
THR A 336
ASN A 274
 None
 0.81A 6f88B-1vb3A:
undetectable		 6f88B-1vb3A:
10.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vko INOSITOL-3-PHOSPHATE
SYNTHASE

(Caenorhabditis
elegans) 		PF01658
(Inos-1-P_synth)
PF07994
(NAD_binding_5) 		4 ALA A 399
LEU A 430
THR A  79
ASN A  76
 None
None
None
NAD  A 601 ( 2.9A)
 0.97A 6f88B-1vkoA:
undetectable		 6f88B-1vkoA:
10.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w7c LYSYL OXIDASE

(Komagataella
pastoris) 		PF01179
(Cu_amine_oxid)
PF02727
(Cu_amine_oxidN2)
PF09248
(DUF1965) 		4 LEU A 523
ALA A 504
LEU A 301
THR A 237
 None
 0.89A 6f88B-1w7cA:
undetectable		 6f88B-1w7cA:
7.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xog NEURAMINIDASE

(Influenza A
virus) 		PF00064
(Neur) 		4 LEU A  92
ALA A 422
LEU A 356
THR A 292
 None
 0.97A 6f88B-1xogA:
undetectable		 6f88B-1xogA:
13.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c79 GLYCOSIDE HYDROLASE,
FAMILY
11:CLOSTRIDIUM
CELLULOSOME ENZYME,
DOCKERIN TYPE
I:POLYSACCHARIDE

(Ruminiclostridium
thermocellum) 		PF01522
(Polysacc_deac_1) 		4 ALA A 569
LEU A 499
THR A 495
ASN A 492
 None
 0.96A 6f88B-2c79A:
undetectable		 6f88B-2c79A:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d0d 2-HYDROXY-6-OXO-7-ME
THYLOCTA-2,4-DIENOAT
E HYDROLASE

(Pseudomonas
fluorescens) 		PF00561
(Abhydrolase_1) 		4 LEU A 212
ALA A 113
LEU A 235
SER A 204
 None
 0.96A 6f88B-2d0dA:
undetectable		 6f88B-2d0dA:
13.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d0j GALACTOSYLGALACTOSYL
XYLOSYLPROTEIN
3-BETA-GLUCURONOSYLT
RANSFERASE 2

(Homo sapiens) 		PF03360
(Glyco_transf_43) 		4 LEU A 135
ALA A 133
SER A 137
THR A  86
 None
 0.88A 6f88B-2d0jA:
undetectable		 6f88B-2d0jA:
15.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e0g CHROMOSOMAL
REPLICATION
INITIATOR PROTEIN
DNAA

(Escherichia
coli) 		PF11638
(DnaA_N) 		4 LEU A  37
ALA A  30
LEU A  61
SER A   3
 None
 0.94A 6f88B-2e0gA:
undetectable		 6f88B-2e0gA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eb0 MANGANESE-DEPENDENT
INORGANIC
PYROPHOSPHATASE

(Methanocaldococcus
jannaschii) 		PF01368
(DHH)
PF02833
(DHHA2) 		4 ALA A 103
LEU A  82
SER A  68
THR A  95
 None
 0.98A 6f88B-2eb0A:
undetectable		 6f88B-2eb0A:
12.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f37 TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 2

(Homo sapiens) 		PF12796
(Ank_2) 		5 LEU A 182
ALA A 170
LEU A 151
SER A 165
THR A 118
 None
 1.47A 6f88B-2f37A:
undetectable		 6f88B-2f37A:
14.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fav REPLICASE
POLYPROTEIN 1AB
(PP1AB) (ORF1AB)

(Severe acute
respiratory
syndrome-related
coronavirus) 		PF01661
(Macro) 		4 LEU A  54
ALA A  57
LEU A 124
ASN A  32
 None
 0.92A 6f88B-2favA:
undetectable		 6f88B-2favA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h7v PROTEIN KINASE YPKA

(Yersinia
pseudotuberculosis) 		PF09632
(Rac1) 		4 LEU C 464
ALA C 459
LEU C 470
THR C 571
 None
 0.87A 6f88B-2h7vC:
undetectable		 6f88B-2h7vC:
12.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hne L-FUCONATE
DEHYDRATASE

(Xanthomonas
campestris) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 LEU A 132
ALA A 125
LEU A 335
THR A 147
 None
 0.95A 6f88B-2hneA:
undetectable		 6f88B-2hneA:
14.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i7x PROTEIN CFT2

(Saccharomyces
cerevisiae) 		PF16661
(Lactamase_B_6) 		4 LEU A 297
LEU A 304
SER A 315
THR A 259
 None
 0.91A 6f88B-2i7xA:
undetectable		 6f88B-2i7xA:
7.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jjy ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE

(Francisella
tularensis) 		PF13561
(adh_short_C2) 		4 LEU A  84
ALA A  86
LEU A  73
THR A  38
 None
 0.93A 6f88B-2jjyA:
undetectable		 6f88B-2jjyA:
14.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2otm HYPOTHETICAL PROTEIN

(Shewanella
oneidensis) 		PF14588
(YjgF_endoribonc) 		4 LEU A 119
ALA A 115
LEU A  79
THR A  38
 None
 0.83A 6f88B-2otmA:
undetectable		 6f88B-2otmA:
24.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qpt EH DOMAIN-CONTAINING
PROTEIN-2

(Mus musculus) 		PF00350
(Dynamin_N)
PF12763
(EF-hand_4)
PF16880
(EHD_N) 		4 LEU A 207
ALA A 206
LEU A  62
THR A 154
 None
 0.94A 6f88B-2qptA:
undetectable		 6f88B-2qptA:
8.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r4f 3-HYDROXY-3-METHYLGL
UTARYL-COENZYME A
REDUCTASE

(Homo sapiens) 		PF00368
(HMG-CoA_red) 		4 LEU A 668
ALA A 667
LEU A 643
THR A 636
 None
 0.98A 6f88B-2r4fA:
undetectable		 6f88B-2r4fA:
11.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rfm PUTATIVE ANKYRIN
REPEAT PROTEIN
TV1425

(Thermoplasma
volcanium) 		PF12796
(Ank_2)
PF13857
(Ank_5) 		4 LEU A 150
ALA A 155
THR A 100
ASN A 128
 None
 0.87A 6f88B-2rfmA:
undetectable		 6f88B-2rfmA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rhm PUTATIVE KINASE

(Chloroflexus
aurantiacus) 		PF13671
(AAA_33) 		4 LEU A  65
ALA A  61
LEU A  32
SER A  83
 None
 0.90A 6f88B-2rhmA:
undetectable		 6f88B-2rhmA:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v0j BIFUNCTIONAL PROTEIN
GLMU

(Haemophilus
influenzae) 		PF00132
(Hexapep)
PF12804
(NTP_transf_3) 		4 LEU A 129
ALA A 217
LEU A 102
THR A  42
 None
 0.72A 6f88B-2v0jA:
undetectable		 6f88B-2v0jA:
10.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v3b RUBREDOXIN REDUCTASE

(Pseudomonas
aeruginosa) 		PF07992
(Pyr_redox_2) 		4 LEU A 150
ALA A 238
LEU A 197
THR A 321
 None
 0.77A 6f88B-2v3bA:
undetectable		 6f88B-2v3bA:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xpi ANAPHASE-PROMOTING
COMPLEX SUBUNIT CUT9

(Schizosaccharomyces
pombe) 		PF12895
(ANAPC3)
PF13181
(TPR_8)
PF13424
(TPR_12) 		4 LEU A 365
ALA A 378
LEU A 332
THR A 328
 None
 0.91A 6f88B-2xpiA:
undetectable		 6f88B-2xpiA:
9.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z66 VARIABLE LYMPHOCYTE
RECEPTOR B,
TOLL-LIKE RECEPTOR 4

(Eptatretus
burgeri;
Homo sapiens) 		PF01462
(LRRNT)
PF13855
(LRR_8) 		4 LEU A  77
ALA A  53
LEU A  82
ASN A  38
 None
 0.96A 6f88B-2z66A:
undetectable		 6f88B-2z66A:
12.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zxo SINGLE-STRANDED DNA
SPECIFIC EXONUCLEASE
RECJ

(Thermus
thermophilus) 		PF01368
(DHH)
PF02272
(DHHA1) 		4 LEU A 605
ALA A 611
LEU A 650
ASN A 657
 None
 0.92A 6f88B-2zxoA:
undetectable		 6f88B-2zxoA:
9.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h09 IMMUNOGLOBULIN A1
PROTEASE

(Haemophilus
influenzae) 		PF02395
(Peptidase_S6)
PF03212
(Pertactin) 		4 ALA A 493
LEU A 528
SER A 518
ASN A 533
 None
 0.96A 6f88B-3h09A:
undetectable		 6f88B-3h09A:
6.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j7a 40S RIBOSOMAL
PROTEIN ES1

(Plasmodium
falciparum) 		PF01015
(Ribosomal_S3Ae) 		4 LEU B  86
ALA B  34
LEU B  70
ASN B  75
 None
 0.95A 6f88B-3j7aB:
undetectable		 6f88B-3j7aB:
13.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k6k ESTERASE/LIPASE

(uncultured
bacterium) 		PF07859
(Abhydrolase_3) 		4 LEU A 253
ALA A 207
LEU A 190
SER A 157
 None
 0.88A 6f88B-3k6kA:
undetectable		 6f88B-3k6kA:
13.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m0c LOW-DENSITY
LIPOPROTEIN RECEPTOR

(Homo sapiens) 		PF00057
(Ldl_recept_a)
PF00058
(Ldl_recept_b)
PF07645
(EGF_CA)
PF14670
(FXa_inhibition) 		4 LEU C 425
ALA C 454
SER C 423
ASN C 543
 None
 0.84A 6f88B-3m0cC:
undetectable		 6f88B-3m0cC:
6.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mm5 SULFITE REDUCTASE,
DISSIMILATORY-TYPE
SUBUNIT ALPHA
SULFITE REDUCTASE,
DISSIMILATORY-TYPE
SUBUNIT BETA

(Archaeoglobus
fulgidus) 		PF00037
(Fer4)
PF01077
(NIR_SIR)
PF03460
(NIR_SIR_ferr) 		4 LEU A 112
LEU B  62
THR B  58
ASN B  88
 None
 0.90A 6f88B-3mm5A:
undetectable		 6f88B-3mm5A:
13.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mvd REGULATOR OF
CHROMOSOME
CONDENSATION

(Drosophila
melanogaster) 		PF00415
(RCC1) 		4 LEU K 174
ALA K 149
LEU K 230
ASN K 159
 None
 0.94A 6f88B-3mvdK:
undetectable		 6f88B-3mvdK:
9.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pih UVRABC SYSTEM
PROTEIN A

(Thermotoga
maritima) 		PF00005
(ABC_tran) 		4 LEU A  26
ALA A 532
LEU A 505
THR A 494
 None
 0.92A 6f88B-3pihA:
undetectable		 6f88B-3pihA:
5.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q54 OUTER MEMBRANE
ASSEMBLY LIPOPROTEIN
YFGL

(Escherichia
coli) 		PF13360
(PQQ_2) 		4 LEU A 111
ALA A 109
LEU A 134
SER A  96
 None
 0.97A 6f88B-3q54A:
undetectable		 6f88B-3q54A:
15.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rag UNCHARACTERIZED
PROTEIN

(Alicyclobacillus
acidocaldarius) 		PF00092
(VWA) 		4 LEU A 222
ALA A 218
LEU A 132
THR A  84
 None
 0.84A 6f88B-3ragA:
undetectable		 6f88B-3ragA:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sg1 UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE 1

(Bacillus
anthracis) 		PF00275
(EPSP_synthase) 		4 LEU A 396
ALA A 375
LEU A  48
ASN A  23
 None
 0.92A 6f88B-3sg1A:
undetectable		 6f88B-3sg1A:
10.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sgi DNA LIGASE

(Mycobacterium
tuberculosis) 		PF01653
(DNA_ligase_aden)
PF03120
(DNA_ligase_OB) 		4 LEU A 129
ALA A 141
LEU A 231
THR A 226
 None
 0.94A 6f88B-3sgiA:
undetectable		 6f88B-3sgiA:
8.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t5t PUTATIVE
GLYCOSYLTRANSFERASE

(Streptomyces
hygroscopicus) 		PF00982
(Glyco_transf_20) 		4 LEU A 376
ALA A 392
LEU A 284
SER A 288
 None
 0.97A 6f88B-3t5tA:
undetectable		 6f88B-3t5tA:
10.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w18 AURORA KINASE A

(Homo sapiens) 		PF00069
(Pkinase) 		4 LEU A 263
ALA A 273
LEU A 139
ASN A 146
 N13  A 501 (-4.5A)
N13  A 501 ( 3.8A)
N13  A 501 (-3.7A)
None
 0.93A 6f88B-3w18A:
undetectable		 6f88B-3w18A:
12.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b93 ANKYRIN REPEAT
DOMAIN-CONTAINING
PROTEIN 27

(Homo sapiens) 		PF12796
(Ank_2)
PF13857
(Ank_5) 		4 LEU B 862
ALA B 867
THR B 812
ASN B 840
 None
 0.96A 6f88B-4b93B:
undetectable		 6f88B-4b93B:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bi9 3-KETOACYL-COA
THIOLASE, PUTATIVE

(Trypanosoma
brucei) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		4 LEU A 267
ALA A 144
LEU A 435
THR A 420
 None
 0.93A 6f88B-4bi9A:
undetectable		 6f88B-4bi9A:
12.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bmr RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
SUBUNIT BETA

(Bacillus cereus) 		PF00268
(Ribonuc_red_sm) 		4 LEU A 268
ALA A 206
LEU A 228
SER A 157
 None
 0.92A 6f88B-4bmrA:
undetectable		 6f88B-4bmrA:
13.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ckb MRNA-CAPPING ENZYME
CATALYTIC SUBUNIT

(Vaccinia virus) 		PF03291
(Pox_MCEL)
PF10640
(Pox_ATPase-GT) 		4 LEU A  18
ALA A  22
LEU A 215
THR A 153
 None
 0.97A 6f88B-4ckbA:
undetectable		 6f88B-4ckbA:
6.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eb7 NIFU PROTEIN
(NIFU-1)

(Archaeoglobus
fulgidus) 		PF01592
(NifU_N) 		4 LEU C  92
ALA C  91
SER C 103
ASN C  15
 None
 0.97A 6f88B-4eb7C:
undetectable		 6f88B-4eb7C:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f1r CATABOLITE
REPRESSION CONTROL
PROTEIN

(Pseudomonas
aeruginosa) 		PF03372
(Exo_endo_phos) 		4 LEU A  20
ALA A  15
LEU A  55
SER A  47
 None
 0.80A 6f88B-4f1rA:
undetectable		 6f88B-4f1rA:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fwv TTC1975 PEPTIDASE

(Meiothermus
taiwanensis) 		PF13654
(AAA_32) 		4 LEU A 310
ALA A 301
LEU A 317
THR A 322
 None
 0.92A 6f88B-4fwvA:
undetectable		 6f88B-4fwvA:
14.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4il1 CALMODULIN,
CALCINEURIN SUBUNIT
B TYPE 1,
SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2B
CATALYTIC SUBUNIT
ALPHA ISOFORM

(Rattus
norvegicus) 		PF00149
(Metallophos)
PF13499
(EF-hand_7) 		4 LEU A 676
LEU A 286
SER A 686
ASN A 266
 None
 0.91A 6f88B-4il1A:
undetectable		 6f88B-4il1A:
6.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jg3 CATABOLITE
REPRESSION CONTROL
PROTEIN

(Pseudomonas
aeruginosa) 		PF03372
(Exo_endo_phos) 		4 LEU A  23
ALA A  18
LEU A  58
SER A  50
 None
 0.84A 6f88B-4jg3A:
undetectable		 6f88B-4jg3A:
13.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k61 UNCHARACTERIZED
PROTEIN

(Bacteroides
uniformis) 		PF11396
(PepSY_like) 		4 LEU A 134
ALA A 119
THR A 150
ASN A 152
 None
 0.88A 6f88B-4k61A:
undetectable		 6f88B-4k61A:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l0o CYSTATHIONINE
GAMMA-SYNTHASE

(Helicobacter
pylori) 		no annotation 4 LEU H 238
ALA H 205
LEU H 245
THR H 175
 None
 0.94A 6f88B-4l0oH:
undetectable		 6f88B-4l0oH:
12.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n3o PUTATIVE
D-GLYCERO-D-MANNO-HE
PTOSE 7-PHOSPHATE
KINASE

(Campylobacter
jejuni) 		PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C) 		4 LEU A  45
ALA A 126
LEU A  97
THR A  93
 None
 0.95A 6f88B-4n3oA:
undetectable		 6f88B-4n3oA:
12.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4on0 NOLR

(Sinorhizobium
fredii) 		PF01022
(HTH_5) 		4 LEU A  48
LEU A  66
SER A  37
ASN A  28
 None
 0.90A 6f88B-4on0A:
undetectable		 6f88B-4on0A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q58 PLECTIN

(Homo sapiens) 		PF00307
(CH) 		4 LEU A  56
ALA A  59
LEU A  70
ASN A 102
 None
 0.92A 6f88B-4q58A:
undetectable		 6f88B-4q58A:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rlv ANKYRIN-1, ANKYRIN-2

(Homo sapiens;
Mus musculus) 		PF00023
(Ank)
PF12796
(Ank_2)
PF13637
(Ank_4)
PF13857
(Ank_5) 		4 LEU A2483
ALA A2488
THR A2433
ASN A2461
 None
 0.89A 6f88B-4rlvA:
undetectable		 6f88B-4rlvA:
6.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u98 MALTOKINASE

(Mycolicibacterium
vanbaalenii) 		PF01636
(APH) 		4 LEU A 308
ALA A 214
LEU A 348
SER A 234
 None
 0.88A 6f88B-4u98A:
undetectable		 6f88B-4u98A:
9.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4urn DNA TOPOISOMERASE
IV, B SUBUNIT

(Staphylococcus
aureus) 		PF02518
(HATPase_c) 		4 LEU A 204
LEU A 194
SER A  50
ASN A 209
 None
None
NOV  A2000 ( 3.7A)
None
 0.95A 6f88B-4urnA:
undetectable		 6f88B-4urnA:
13.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v2e FIBRONECTIN LEUCINE
RICH TRANSMEMBRANE
PROTEIN 3

(Mus musculus) 		PF01462
(LRRNT)
PF13855
(LRR_8) 		4 LEU A 102
LEU A 133
SER A 123
ASN A 138
 None
 0.81A 6f88B-4v2eA:
undetectable		 6f88B-4v2eA:
12.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yb6 ATP
PHOSPHORIBOSYLTRANSF
ERASE

(Campylobacter
jejuni) 		PF01634
(HisG)
PF08029
(HisG_C) 		4 LEU A 170
LEU A 134
SER A 191
ASN A  80
 AMP  A 301 (-4.3A)
None
None
MG  A 304 ( 4.2A)
 0.80A 6f88B-4yb6A:
undetectable		 6f88B-4yb6A:
12.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yeb FIBRONECTIN LEUCINE
RICH TRANSMEMBRANE
PROTEIN 3

(Mus musculus) 		PF13855
(LRR_8) 		4 LEU B 102
LEU B 133
SER B 123
ASN B 138
 None
 0.91A 6f88B-4yebB:
undetectable		 6f88B-4yebB:
11.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ywh ABC TRANSPORTER
SOLUTE BINDING
PROTEIN

(Actinobacillus
succinogenes) 		PF13407
(Peripla_BP_4) 		4 LEU A 304
ALA A 302
LEU A 163
ASN A 117
 None
 0.93A 6f88B-4ywhA:
undetectable		 6f88B-4ywhA:
13.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z61 PHYTOSULFOKINE
RECEPTOR 1

(Daucus carota) 		PF00560
(LRR_1)
PF13855
(LRR_8) 		4 LEU A 130
ALA A 107
LEU A 117
SER A 103
 None
 0.87A 6f88B-4z61A:
undetectable		 6f88B-4z61A:
8.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zpj EXTRACELLULAR
LIGAND-BINDING
RECEPTOR

(Sphaerobacter
thermophilus) 		PF13458
(Peripla_BP_6) 		4 ALA A 289
LEU A 362
THR A 333
ASN A 435
 None
 0.81A 6f88B-4zpjA:
undetectable		 6f88B-4zpjA:
15.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b5x LIMITING
CO2-INDUCIBLE
PROTEIN LCIC

(Chlamydomonas
reinhardtii) 		no annotation 4 LEU A 213
ALA A 221
LEU A 264
THR A 268
 None
 0.88A 6f88B-5b5xA:
undetectable		 6f88B-5b5xA:
13.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b8i CALCINEURIN SUBUNIT
B, VARIANT
SERINE/THREONINE-PRO
TEIN PHOSPHATASE

(Coccidioides
immitis) 		PF00149
(Metallophos)
PF13202
(EF-hand_5)
PF13499
(EF-hand_7) 		4 LEU A 361
LEU B 129
SER A 371
ASN B 109
 None
None
FK5  C 201 (-4.6A)
None
 0.93A 6f88B-5b8iA:
undetectable		 6f88B-5b8iA:
15.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dlk TQAA

(Penicillium
aethiopicum) 		PF00668
(Condensation) 		4 LEU A 445
ALA A 450
LEU A 387
THR A 292
 None
 0.93A 6f88B-5dlkA:
undetectable		 6f88B-5dlkA:
9.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ds0 PEPTIDASE M42

(Thaumarchaeota
archaeon SCGC
AB-539-E09) 		PF05343
(Peptidase_M42) 		4 LEU A 188
ALA A 185
LEU A  62
THR A 224
 None
 0.89A 6f88B-5ds0A:
undetectable		 6f88B-5ds0A:
11.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eid ANKYRIN REPEAT
DOMAIN-CONTAINING
PROTEIN 2

(Arabidopsis
thaliana) 		PF13637
(Ank_4) 		4 LEU A 336
ALA A 340
THR A 286
ASN A 314
 None
 0.98A 6f88B-5eidA:
undetectable		 6f88B-5eidA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ft6 CYSTEINE DESULFURASE
CSDA

(Escherichia
coli) 		PF00266
(Aminotran_5) 		4 LEU A  76
ALA A 206
THR A  90
ASN A 122
 None
None
PLP  A1222 (-4.0A)
None
 0.96A 6f88B-5ft6A:
undetectable		 6f88B-5ft6A:
12.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g56 CARBOHYDRATE BINDING
FAMILY 6

(Ruminiclostridium
thermocellum) 		PF00150
(Cellulase)
PF03422
(CBM_6) 		4 LEU A 308
ALA A  88
LEU A 210
SER A 306
 None
 0.97A 6f88B-5g56A:
undetectable		 6f88B-5g56A:
6.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gmb TRNA
(CYTIDINE/URIDINE-2'
-O-)-METHYLTRANSFERA
SE TRMJ

(Pseudomonas
aeruginosa) 		PF00588
(SpoU_methylase) 		4 LEU A  57
ALA A  50
LEU A  35
THR A  12
 None
 0.92A 6f88B-5gmbA:
undetectable		 6f88B-5gmbA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gnc AVH146

(Phytophthora
sojae) 		no annotation 4 LEU A 623
ALA A 626
LEU A 573
ASN A 580
 None
 0.85A 6f88B-5gncA:
undetectable		 6f88B-5gncA:
8.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5if3 SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE SDR

(Burkholderia
vietnamiensis) 		PF00106
(adh_short) 		4 LEU A  72
ALA A 127
LEU A  62
THR A  15
 None
 0.68A 6f88B-5if3A:
undetectable		 6f88B-5if3A:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l6y INTERLEUKIN-13

(Homo sapiens) 		PF03487
(IL13) 		4 LEU C  50
ALA C  46
LEU C  27
THR C  20
 None
 0.95A 6f88B-5l6yC:
undetectable		 6f88B-5l6yC:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l9w ACETOPHENONE
CARBOXYLASE DELTA
SUBUNIT

(Aromatoleum
aromaticum) 		PF02538
(Hydantoinase_B) 		4 LEU A 349
ALA A 308
THR A 506
ASN A 394
 None
None
K  A 703 ( 4.4A)
None
 0.92A 6f88B-5l9wA:
undetectable		 6f88B-5l9wA:
8.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5la0 CARBOHYDRATE BINDING
FAMILY 6

(Ruminiclostridium
thermocellum) 		PF00150
(Cellulase)
PF03422
(CBM_6) 		4 LEU A 308
ALA A  88
LEU A 210
SER A 306
 None
 0.95A 6f88B-5la0A:
undetectable		 6f88B-5la0A:
9.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5liv CYTOCHROME P450
CYP260A1,CYTOCHROME
P450 CYP260A1

(Sorangium
cellulosum) 		PF00067
(p450) 		5 LEU A 119
ALA A 124
LEU A 209
SER A 275
THR A 283
 None
HEM  A 501 (-3.9A)
None
HEM  A 501 ( 3.8A)
GOL  A 502 (-4.0A)
 0.50A 6f88B-5livA:
68.2		 6f88B-5livA:
61.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lnq 3-KETOACYL-COA
THIOLASE-LIKE
PROTEIN

(Leishmania
mexicana) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		4 LEU A 270
ALA A 147
LEU A 438
THR A 423
 None
 0.82A 6f88B-5lnqA:
undetectable		 6f88B-5lnqA:
11.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mx0 FIBROMODULIN

(Homo sapiens) 		PF01462
(LRRNT)
PF13516
(LRR_6)
PF13855
(LRR_8) 		4 LEU A 196
ALA A 195
LEU A 228
ASN A 233
 None
 0.97A 6f88B-5mx0A:
undetectable		 6f88B-5mx0A:
11.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5opq 3,6-ANHYDRO-D-GALACT
OSIDASE

(Zobellia
galactanivorans) 		no annotation 4 LEU A 480
LEU A 405
SER A 420
THR A 384
 None
 0.97A 6f88B-5opqA:
undetectable		 6f88B-5opqA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uam ULVAN LYASE-PL25

(Pseudoalteromonas
sp. PLSV) 		PF15892
(BNR_4) 		4 LEU A  62
LEU A 467
SER A  80
THR A  77
 None
 0.91A 6f88B-5uamA:
undetectable		 6f88B-5uamA:
10.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ubg ATP
PHOSPHORIBOSYLTRANSF
ERASE

(Campylobacter
jejuni) 		no annotation 4 LEU A 170
LEU A 134
SER A 191
ASN A  80
 PRT  A 302 (-4.2A)
None
PRT  A 302 ( 4.2A)
None
 0.81A 6f88B-5ubgA:
undetectable		 6f88B-5ubgA:
17.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5utu ADENOSYLHOMOCYSTEINA
SE

(Cryptosporidium
parvum) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		4 LEU A 429
ALA A 425
LEU A 230
THR A 142
 None
 0.91A 6f88B-5utuA:
undetectable		 6f88B-5utuA:
9.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wi5 UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE 1

(Streptococcus
pneumoniae) 		PF00275
(EPSP_synthase) 		4 LEU A 399
ALA A 378
LEU A  49
ASN A  24
 None
None
None
EPU  A 503 (-3.1A)
 0.96A 6f88B-5wi5A:
undetectable		 6f88B-5wi5A:
11.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xn7 PUTATIVE RTX-TOXIN

(Vibrio
vulnificus) 		PF11647
(MLD) 		4 LEU A2381
ALA A2385
LEU A2427
ASN A2486
 None
 0.96A 6f88B-5xn7A:
undetectable		 6f88B-5xn7A:
9.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y31 LEUCINE-RICH
GLIOMA-INACTIVATED
PROTEIN 1

(Homo sapiens) 		no annotation 4 ALA B 110
LEU B 146
SER B 131
ASN B 125
 None
 0.94A 6f88B-5y31B:
undetectable		 6f88B-5y31B:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y4f ANKYRIN-2

(Homo sapiens) 		PF00023
(Ank)
PF12796
(Ank_2)
PF13637
(Ank_4)
PF13857
(Ank_5) 		4 LEU A 482
ALA A 487
THR A 432
ASN A 460
 None
 0.96A 6f88B-5y4fA:
undetectable		 6f88B-5y4fA:
9.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6az1 RIBOSOMAL PROTEIN S7

(Leishmania
donovani) 		no annotation 4 LEU H   8
ALA H  33
LEU H  79
ASN H  60
 None
None
None
A  12031 ( 3.3A)
 0.93A 6f88B-6az1H:
undetectable		 6f88B-6az1H:
24.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bwm TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 2

(Oryctolagus
cuniculus) 		no annotation 5 LEU A 181
ALA A 169
LEU A 150
SER A 164
THR A 117
 None
 1.48A 6f88B-6bwmA:
undetectable		 6f88B-6bwmA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6elc VARIANT SURFACE
GLYCOPROTEIN

(Trypanosoma
brucei) 		no annotation 4 LEU A 116
ALA A 112
LEU A 126
ASN A 378
 None
 0.97A 6f88B-6elcA:
undetectable		 6f88B-6elcA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eq8 PERIPLASMIC
ALPHA-GALACTOSIDE-BI
NDING PROTEIN

(Agrobacterium
tumefaciens) 		no annotation 4 ALA D   8
LEU D 451
SER D 401
ASN D 392
 None
 0.92A 6f88B-6eq8D:
undetectable		 6f88B-6eq8D:
22.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6f85 CYTOCHROME P450
CYP260A1

(Sorangium
cellulosum) 		no annotation 6 LEU A  69
ALA A  74
LEU A 159
SER A 225
THR A 233
ASN A 276
 HIS  A 502 (-4.9A)
HEM  A 501 (-3.8A)
HIS  A 502 (-4.6A)
HEM  A 501 ( 4.0A)
HIS  A 502 ( 3.5A)
HEM  A 501 (-4.3A)
 0.47A 6f88B-6f85A:
69.6		 6f88B-6f85A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f9m SERINE PROTEASE

(Planococcus
plakortidis) 		no annotation 4 LEU A 247
ALA A 245
LEU A   6
THR A  50
 None
 0.96A 6f88B-6f9mA:
undetectable		 6f88B-6f9mA:
20.73