SIMILAR PATTERNS OF AMINO ACIDS FOR 6F88_A_STRA502_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a41 TOPOISOMERASE I

(Vaccinia virus) 		PF01028
(Topoisom_I) 		4 PHE A 288
LEU A 289
SER A 247
THR A 255
 None
 0.88A 6f88A-1a41A:
1.2		 6f88A-1a41A:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1aha ALPHA-MOMORCHARIN

(Momordica
charantia) 		PF00161
(RIP) 		4 PHE A  83
LEU A 105
SER A 144
THR A 138
 ADE  A 339 ( 4.8A)
None
None
None
 0.98A 6f88A-1ahaA:
0.0		 6f88A-1ahaA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f2e GLUTATHIONE
S-TRANSFERASE

(Sphingomonas
paucimobilis) 		PF00043
(GST_C)
PF02798
(GST_N) 		4 PHE A  25
LEU A   3
ALA A  27
SER A  11
 None
 0.95A 6f88A-1f2eA:
undetectable		 6f88A-1f2eA:
16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fjj HYPOTHETICAL 17.1
KDA PROTEIN IN
MODC-BIOA INTERGENIC
REGION

(Escherichia
coli) 		PF01161
(PBP) 		4 PHE A 118
LEU A   8
ALA A 155
ASN A  29
 None
 0.96A 6f88A-1fjjA:
0.0		 6f88A-1fjjA:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gng GLYCOGEN SYNTHASE
KINASE-3 BETA

(Homo sapiens) 		PF00069
(Pkinase) 		4 LEU A 332
ALA A 170
SER A 368
ASN A 361
 None
 0.78A 6f88A-1gngA:
0.0		 6f88A-1gngA:
11.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i78 PROTEASE VII

(Escherichia
coli) 		PF01278
(Omptin) 		4 PHE A  46
LEU A 106
ALA A  49
ASN A 254
 None
 0.95A 6f88A-1i78A:
undetectable		 6f88A-1i78A:
12.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1idj PECTIN LYASE A

(Aspergillus
niger) 		PF00544
(Pec_lyase_C) 		4 PHE A 332
LEU A 329
SER A 325
ASN A 274
 None
 1.01A 6f88A-1idjA:
0.0		 6f88A-1idjA:
12.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iqp RFCS

(Pyrococcus
furiosus) 		PF00004
(AAA)
PF08542
(Rep_fac_C) 		4 PHE A 164
LEU A  49
ALA A 162
THR A  43
 None
 0.76A 6f88A-1iqpA:
0.0		 6f88A-1iqpA:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k9a CARBOXYL-TERMINAL
SRC KINASE

(Rattus
norvegicus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		4 PHE A 233
LEU A 234
ALA A 230
SER A  78
 None
 0.94A 6f88A-1k9aA:
0.0		 6f88A-1k9aA:
10.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ltd FLAVOCYTOCHROME B2

(Saccharomyces
cerevisiae) 		PF00173
(Cyt-b5)
PF01070
(FMN_dh) 		4 LEU A 136
ALA A 132
SER A 145
THR A 197
 None
None
None
FMN  A 570 ( 4.8A)
 1.00A 6f88A-1ltdA:
undetectable		 6f88A-1ltdA:
9.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1np8 CALCIUM-DEPENDENT
PROTEASE, SMALL
SUBUNIT

(Rattus
norvegicus) 		PF13833
(EF-hand_8) 		4 PHE A  21
ALA A  25
SER A  32
THR A  72
 None
CD  A 703 (-4.4A)
CD  A 703 ( 4.8A)
CD  A 700 (-3.0A)
 0.85A 6f88A-1np8A:
undetectable		 6f88A-1np8A:
16.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o94 ELECTRON TRANSFER
FLAVOPROTEIN
BETA-SUBUNIT
TRIMETHYLAMINE
DEHYDROGENASE

(Methylophilus
methylotrophus) 		PF00724
(Oxidored_FMN)
PF01012
(ETF)
PF07992
(Pyr_redox_2) 		4 LEU A 393
ALA A 480
SER C 193
ASN A 458
 None
 1.03A 6f88A-1o94A:
undetectable		 6f88A-1o94A:
8.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oy3 TRANSCRIPTION FACTOR
INHIBITOR
I-KAPPA-B-BETA

(Mus musculus) 		PF12796
(Ank_2)
PF13637
(Ank_4) 		4 LEU D 226
ALA D 231
THR D 129
ASN D 204
 None
 0.98A 6f88A-1oy3D:
undetectable		 6f88A-1oy3D:
13.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pjb L-ALANINE
DEHYDROGENASE

(Phormidium
lapideum) 		PF01262
(AlaDh_PNT_C)
PF05222
(AlaDh_PNT_N) 		4 PHE A  45
ALA A  43
THR A 316
ASN A 314
 None
 0.96A 6f88A-1pjbA:
undetectable		 6f88A-1pjbA:
12.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pm2 RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE 1
BETA CHAIN

(Escherichia
coli) 		PF00268
(Ribonuc_red_sm) 		4 PHE A 276
LEU A 275
ALA A 202
ASN A 250
 None
 0.91A 6f88A-1pm2A:
undetectable		 6f88A-1pm2A:
9.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qho ALPHA-AMYLASE

(Geobacillus
stearothermophilus) 		PF00128
(Alpha-amylase)
PF00686
(CBM_20)
PF01833
(TIG)
PF02806
(Alpha-amylase_C) 		4 LEU A 482
ALA A 483
SER A 488
ASN A 342
 None
 0.97A 6f88A-1qhoA:
undetectable		 6f88A-1qhoA:
8.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qlb FUMARATE REDUCTASE
IRON-SULFUR PROTEIN

(Wolinella
succinogenes) 		PF13085
(Fer2_3)
PF13183
(Fer4_8) 		4 PHE B  97
LEU B  94
ALA B 159
SER B  74
 None
 0.91A 6f88A-1qlbB:
undetectable		 6f88A-1qlbB:
15.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rzr GLUCOSE-RESISTANCE
AMYLASE REGULATOR

(Bacillus
megaterium) 		no annotation 4 LEU G 233
ALA G 181
SER G 214
ASN G 192
 None
None
SO4  G 647 (-3.5A)
None
 0.88A 6f88A-1rzrG:
undetectable		 6f88A-1rzrG:
12.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s72 50S RIBOSOMAL
PROTEIN L15E

(Haloarcula
marismortui) 		PF00827
(Ribosomal_L15e) 		4 PHE M 109
LEU M 133
ALA M 105
SER M 117
 U  0 134 (-4.5A)
None
None
None
 1.02A 6f88A-1s72M:
undetectable		 6f88A-1s72M:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1su7 CARBON MONOXIDE
DEHYDROGENASE 2

(Carboxydothermus
hydrogenoformans) 		PF03063
(Prismane) 		4 PHE A 154
LEU A 151
ALA A 150
ASN A 262
 None
 1.02A 6f88A-1su7A:
undetectable		 6f88A-1su7A:
9.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xqp 8-OXOGUANINE DNA
GLYCOSYLASE

(Pyrobaculum
aerophilum) 		PF09171
(AGOG) 		4 PHE A 245
LEU A 244
ALA A 182
THR A 210
 None
 0.86A 6f88A-1xqpA:
undetectable		 6f88A-1xqpA:
13.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yve ACETOHYDROXY ACID
ISOMEROREDUCTASE

(Spinacia
oleracea) 		PF01450
(IlvC)
PF07991
(IlvN) 		4 PHE I 122
LEU I 118
ALA I 121
THR I 303
 None
 0.93A 6f88A-1yveI:
undetectable		 6f88A-1yveI:
10.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bi3 PHOSPHOSERINE
AMINOTRANSFERASE

(Bacillus
alcalophilus) 		PF00266
(Aminotran_5) 		4 PHE A 321
LEU A 324
ALA A 316
THR A 277
 None
 0.97A 6f88A-2bi3A:
undetectable		 6f88A-2bi3A:
13.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ch1 3-HYDROXYKYNURENINE
TRANSAMINASE

(Anopheles
gambiae) 		PF00266
(Aminotran_5) 		4 PHE A 189
LEU A 184
ALA A 180
THR A  71
 None
 1.00A 6f88A-2ch1A:
undetectable		 6f88A-2ch1A:
11.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e27 ANTI-CIGUATOXIN
ANTIBODY, HEAVY
CHAIN

(Mus musculus) 		PF07686
(V-set) 		4 LEU H 823
ALA H  12
SER H  87
THR H 107
 None
None
GOL  H5002 ( 4.3A)
None
 0.90A 6f88A-2e27H:
undetectable		 6f88A-2e27H:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eg3 PROBABLE THIOSULFATE
SULFURTRANSFERASE

(Thermus
thermophilus) 		PF00581
(Rhodanese) 		4 PHE A 202
ALA A 198
SER A  73
THR A  12
 None
None
SO4  A 505 (-4.0A)
None
 0.98A 6f88A-2eg3A:
undetectable		 6f88A-2eg3A:
17.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eyq TRANSCRIPTION-REPAIR
COUPLING FACTOR

(Escherichia
coli) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF02559
(CarD_CdnL_TRCF)
PF03461
(TRCF) 		4 LEU A1060
ALA A1064
SER A 524
ASN A 473
 None
 0.99A 6f88A-2eyqA:
0.6		 6f88A-2eyqA:
5.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kbx INTEGRIN-LINKED
PROTEIN KINASE

(Homo sapiens) 		PF12796
(Ank_2) 		4 LEU A 119
ALA A 124
THR A  69
ASN A  97
 None
 0.94A 6f88A-2kbxA:
undetectable		 6f88A-2kbxA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rfa TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 6

(Mus musculus) 		PF12796
(Ank_2)
PF13637
(Ank_4) 		4 PHE A 152
ALA A 147
SER A 168
ASN A 127
 None
 0.99A 6f88A-2rfaA:
undetectable		 6f88A-2rfaA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rfm PUTATIVE ANKYRIN
REPEAT PROTEIN
TV1425

(Thermoplasma
volcanium) 		PF12796
(Ank_2)
PF13857
(Ank_5) 		4 LEU A 150
ALA A 155
THR A 100
ASN A 128
 None
 0.84A 6f88A-2rfmA:
undetectable		 6f88A-2rfmA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v9t SLIT HOMOLOG 2
PROTEIN N-PRODUCT

(Homo sapiens) 		PF01462
(LRRNT)
PF01463
(LRRCT)
PF13855
(LRR_8) 		4 PHE B 344
LEU B 367
ALA B 343
ASN B 334
 None
 0.99A 6f88A-2v9tB:
undetectable		 6f88A-2v9tB:
15.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wyo GLUTATHIONE
SYNTHETASE

(Trypanosoma
brucei) 		PF03199
(GSH_synthase)
PF03917
(GSH_synth_ATP) 		4 PHE A 381
LEU A 376
ALA A 380
THR A 120
 None
 0.92A 6f88A-2wyoA:
undetectable		 6f88A-2wyoA:
10.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fr8 PUTATIVE KETOL-ACID
REDUCTOISOMERASE
(OS05G0573700
PROTEIN)

(Oryza sativa) 		PF01450
(IlvC)
PF07991
(IlvN) 		4 PHE A 122
LEU A 118
ALA A 121
THR A 303
 None
 0.95A 6f88A-3fr8A:
undetectable		 6f88A-3fr8A:
10.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3get HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE

(Campylobacter
jejuni) 		PF00155
(Aminotran_1_2) 		4 PHE A 311
ALA A 341
THR A 305
ASN A 162
 None
 0.97A 6f88A-3getA:
undetectable		 6f88A-3getA:
16.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i04 CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT BETA

(Moorella
thermoacetica) 		PF03063
(Prismane) 		4 PHE A 174
LEU A 171
ALA A 170
ASN A 284
 None
 1.02A 6f88A-3i04A:
0.2		 6f88A-3i04A:
8.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iy1 FAB B, HEAVY CHAIN

(Rattus
norvegicus) 		PF07686
(V-set) 		4 LEU B 187
ALA B 113
SER B 192
THR B 211
 None
 1.02A 6f88A-3iy1B:
undetectable		 6f88A-3iy1B:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m1l 3-OXOACYL-(ACYL-CARR
IER-PROTEIN)
REDUCTASE

(Mycobacterium
tuberculosis) 		PF13561
(adh_short_C2) 		4 LEU A 281
ALA A 289
THR A 219
ASN A 294
 None
 1.03A 6f88A-3m1lA:
undetectable		 6f88A-3m1lA:
12.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oos ALPHA/BETA HYDROLASE
FAMILY PROTEIN

(Bacillus
anthracis) 		PF00561
(Abhydrolase_1) 		4 PHE A 176
LEU A 182
ALA A 172
ASN A  39
 None
 1.03A 6f88A-3oosA:
undetectable		 6f88A-3oosA:
14.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3prx COBRA VENOM FACTOR

(Naja kaouthia) 		PF00207
(A2M)
PF01759
(NTR)
PF01821
(ANATO)
PF01835
(A2M_N)
PF07677
(A2M_recep)
PF07678
(A2M_comp)
PF07703
(A2M_N_2)
PF10569
(Thiol-ester_cl) 		4 LEU B 120
ALA B 641
SER B 122
THR B  96
 None
 1.03A 6f88A-3prxB:
undetectable		 6f88A-3prxB:
4.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pvc TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC

(Yersinia pestis) 		PF01266
(DAO)
PF05430
(Methyltransf_30) 		4 PHE A 225
LEU A 220
ALA A 223
THR A  65
 None
 0.89A 6f88A-3pvcA:
undetectable		 6f88A-3pvcA:
8.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pz2 GERANYLGERANYL
TRANSFERASE TYPE-2
SUBUNIT BETA

(Rattus
norvegicus) 		PF00432
(Prenyltrans) 		4 LEU B 300
ALA B 247
SER B 310
THR B  55
 None
 0.98A 6f88A-3pz2B:
undetectable		 6f88A-3pz2B:
12.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qgm P-NITROPHENYL
PHOSPHATASE (PHO2)

(Archaeoglobus
fulgidus) 		PF13242
(Hydrolase_like)
PF13344
(Hydrolase_6) 		4 PHE A  91
LEU A 118
ALA A 137
ASN A 127
 None
 0.96A 6f88A-3qgmA:
undetectable		 6f88A-3qgmA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t6q CD180 ANTIGEN

(Mus musculus) 		PF13855
(LRR_8) 		4 PHE A  97
LEU A 121
ALA A 120
ASN A 111
 None
 0.95A 6f88A-3t6qA:
undetectable		 6f88A-3t6qA:
8.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t6q CD180 ANTIGEN

(Mus musculus) 		PF13855
(LRR_8) 		4 PHE A  97
LEU A 121
ALA A 120
THR A 135
 None
 0.96A 6f88A-3t6qA:
undetectable		 6f88A-3t6qA:
8.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ukn NOVEL PROTEIN
SIMILAR TO
VERTEBRATE POTASSIUM
VOLTAGE-GATED
CHANNEL, SUBFAMILY H
(EAG-RELATED) FAMILY

(Danio rerio) 		PF00027
(cNMP_binding) 		4 PHE A 621
LEU A 620
SER A 732
THR A 689
 None
 1.03A 6f88A-3uknA:
undetectable		 6f88A-3uknA:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vac CFA/I FIMBRIAL
SUBUNIT E

(Escherichia
coli) 		PF07434
(CblD) 		5 PHE A 123
ALA A 151
SER A 154
THR A  98
ASN A 137
 None
 1.42A 6f88A-3vacA:
undetectable		 6f88A-3vacA:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wfl BETA-MANNANASE

(Talaromyces
trachyspermus) 		PF00150
(Cellulase) 		4 LEU A 107
ALA A 154
SER A 172
ASN A 141
 None
 0.89A 6f88A-3wflA:
undetectable		 6f88A-3wflA:
12.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wfz LACTO-N-BIOSE
PHOSPHORYLASE

(Bifidobacterium
longum) 		PF09508
(Lact_bio_phlase)
PF17385
(LBP_M)
PF17386
(LBP_C) 		4 LEU A 462
ALA A 459
THR A 169
ASN A 166
 None
None
None
NDG  A4001 ( 4.6A)
 0.94A 6f88A-3wfzA:
undetectable		 6f88A-3wfzA:
8.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wgo MESO-DIAMINOPIMELATE
DEHYDROGENASE

(Clostridium
tetani) 		PF16654
(DAPDH_C) 		4 LEU A  76
ALA A  73
SER A 120
THR A 280
 None
 0.94A 6f88A-3wgoA:
undetectable		 6f88A-3wgoA:
14.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zyi LEUCINE-RICH
REPEAT-CONTAINING
PROTEIN 4

(Homo sapiens) 		PF07679
(I-set)
PF13855
(LRR_8) 		4 PHE A 262
LEU A 285
ALA A 261
ASN A 276
 None
 1.00A 6f88A-3zyiA:
undetectable		 6f88A-3zyiA:
8.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4akx SPCU

(Pseudomonas
aeruginosa) 		no annotation 4 PHE A  42
LEU A 100
ALA A  90
ASN A  17
 None
 1.01A 6f88A-4akxA:
undetectable		 6f88A-4akxA:
23.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b93 ANKYRIN REPEAT
DOMAIN-CONTAINING
PROTEIN 27

(Homo sapiens) 		PF12796
(Ank_2)
PF13857
(Ank_5) 		4 LEU B 862
ALA B 867
THR B 812
ASN B 840
 None
 0.90A 6f88A-4b93B:
undetectable		 6f88A-4b93B:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bsz ANKYRIN
REPEAT-CONTAINING
PROTEIN YAR1

(Saccharomyces
cerevisiae) 		PF12796
(Ank_2) 		4 LEU B 112
ALA B 118
THR B  52
ASN B  90
 None
 0.85A 6f88A-4bszB:
undetectable		 6f88A-4bszB:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eb7 NIFU PROTEIN
(NIFU-1)

(Archaeoglobus
fulgidus) 		PF01592
(NifU_N) 		4 LEU C  92
ALA C  91
SER C 103
ASN C  15
 None
 0.88A 6f88A-4eb7C:
undetectable		 6f88A-4eb7C:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h09 HYPOTHETICAL LEUCINE
RICH REPEAT PROTEIN

(Eubacterium
ventriosum) 		PF13306
(LRR_5) 		4 PHE A 267
LEU A 289
ALA A 266
ASN A 281
 None
 0.99A 6f88A-4h09A:
undetectable		 6f88A-4h09A:
11.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hea NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT 13

(Thermus
thermophilus) 		PF00361
(Proton_antipo_M) 		4 PHE M 396
ALA M 395
SER M 388
THR M 304
 None
 0.96A 6f88A-4heaM:
undetectable		 6f88A-4heaM:
10.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iml CROSSED HEAVY CHAIN
(VH-CKAPPA)

(Homo sapiens) 		no annotation 4 LEU H 147
ALA H 152
SER H 143
ASN H 232
 None
 0.94A 6f88A-4imlH:
undetectable		 6f88A-4imlH:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iu9 NITRITE EXTRUSION
PROTEIN 2

(Escherichia
coli) 		no annotation 4 PHE B  53
LEU B  75
ALA B 135
THR B 126
 None
 0.93A 6f88A-4iu9B:
undetectable		 6f88A-4iu9B:
12.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k61 UNCHARACTERIZED
PROTEIN

(Bacteroides
uniformis) 		PF11396
(PepSY_like) 		4 LEU A 134
ALA A 119
THR A 150
ASN A 152
 None
 0.92A 6f88A-4k61A:
undetectable		 6f88A-4k61A:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m8n PLEXINC1
INTRACELLULAR REGION
RAS-RELATED PROTEIN
RAP-1B

(Danio rerio;
Homo sapiens) 		PF00071
(Ras)
PF08337
(Plexin_cytopl) 		4 PHE E  28
ALA E  18
THR E  85
ASN A 705
 GDP  E 201 (-4.7A)
GDP  E 201 (-3.2A)
None
None
 0.96A 6f88A-4m8nE:
undetectable		 6f88A-4m8nE:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oet PUTATIVE PEPTIDE
ABC-TRANSPORT SYSTEM
PERIPLASMIC
PEPTIDE-BINDING
PROTEIN

(Campylobacter
jejuni) 		PF00496
(SBP_bac_5) 		4 PHE A 316
LEU A 311
ALA A 314
ASN A 250
 None
 0.79A 6f88A-4oetA:
undetectable		 6f88A-4oetA:
9.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ot9 NUCLEAR FACTOR
NF-KAPPA-B P100
SUBUNIT

(Homo sapiens) 		PF12796
(Ank_2) 		4 LEU A 546
ALA A 551
THR A 490
ASN A 524
 None
 1.01A 6f88A-4ot9A:
undetectable		 6f88A-4ot9A:
14.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qxe LEUCINE-RICH
REPEAT-CONTAINING
G-PROTEIN COUPLED
RECEPTOR 4, LINKER,
VARIABLE LYMPHOCYTE
RECEPTOR B

(Eptatretus
burgeri;
Homo sapiens) 		PF01462
(LRRNT)
PF11921
(DUF3439)
PF13516
(LRR_6)
PF13855
(LRR_8) 		4 PHE A  77
LEU A 101
ALA A 100
ASN A  91
 None
 1.00A 6f88A-4qxeA:
undetectable		 6f88A-4qxeA:
12.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qxe LEUCINE-RICH
REPEAT-CONTAINING
G-PROTEIN COUPLED
RECEPTOR 4, LINKER,
VARIABLE LYMPHOCYTE
RECEPTOR B

(Eptatretus
burgeri;
Homo sapiens) 		PF01462
(LRRNT)
PF11921
(DUF3439)
PF13516
(LRR_6)
PF13855
(LRR_8) 		4 PHE A 197
ALA A 196
SER A 217
ASN A 211
 None
 0.82A 6f88A-4qxeA:
undetectable		 6f88A-4qxeA:
12.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qxf LEUCINE-RICH
REPEAT-CONTAINING
G-PROTEIN COUPLED
RECEPTOR 4, VARIABLE
LYMPHOCYTE RECEPTOR
B

(Eptatretus
burgeri;
Homo sapiens) 		PF01462
(LRRNT)
PF11921
(DUF3439)
PF13855
(LRR_8) 		4 PHE A  77
LEU A 101
ALA A 100
ASN A  91
 None
 1.01A 6f88A-4qxfA:
undetectable		 6f88A-4qxfA:
13.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r9n LMO0547 PROTEIN

(Listeria
monocytogenes) 		PF04198
(Sugar-bind) 		4 PHE A 123
LEU A 278
ALA A  98
THR A 274
 None
 1.03A 6f88A-4r9nA:
undetectable		 6f88A-4r9nA:
14.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rlv ANKYRIN-1, ANKYRIN-2

(Homo sapiens;
Mus musculus) 		PF00023
(Ank)
PF12796
(Ank_2)
PF13637
(Ank_4)
PF13857
(Ank_5) 		4 LEU A2483
ALA A2488
THR A2433
ASN A2461
 None
 0.86A 6f88A-4rlvA:
undetectable		 6f88A-4rlvA:
6.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u28 PHOSPHORIBOSYL
ISOMERASE A

(Streptomyces
sviceus) 		PF00977
(His_biosynth) 		4 PHE A  62
LEU A  58
ALA A  61
THR A 170
 None
None
PO4  A 302 (-3.3A)
None
 0.96A 6f88A-4u28A:
undetectable		 6f88A-4u28A:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wd0 1-(5-PHOSPHORIBOSYL)
-5-[(5-PHOSPHORIBOSY
LAMINO)METHYLIDENEAM
INO]
IMIDAZOLE-4-CARBOXAM
IDE ISOMERASE

(Paenarthrobacter
aurescens) 		PF00977
(His_biosynth) 		4 PHE A  63
LEU A  59
ALA A  62
THR A 171
 None
None
TRS  A 304 (-3.3A)
None
 0.87A 6f88A-4wd0A:
undetectable		 6f88A-4wd0A:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wq3 CALPAIN SMALL
SUBUNIT 1

(Homo sapiens) 		PF13202
(EF-hand_5)
PF13833
(EF-hand_8) 		4 PHE A 105
ALA A 109
SER A 116
THR A 156
 None
CA  A 301 (-4.7A)
CA  A 301 ( 4.9A)
CA  A 302 (-3.0A)
 0.80A 6f88A-4wq3A:
undetectable		 6f88A-4wq3A:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x2r 1-(5-PHOSPHORIBOSYL)
-5-[(5-PHOSPHORIBOSY
LAMINO)METHYLIDENEAM
INO]
IMIDAZOLE-4-CARBOXAM
IDE ISOMERASE

(Actinomyces
urogenitalis) 		PF00977
(His_biosynth) 		4 PHE A  56
LEU A  52
ALA A  55
THR A 164
 None
None
PO4  A 304 (-3.2A)
None
 1.02A 6f88A-4x2rA:
undetectable		 6f88A-4x2rA:
16.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x9s PHOSPHORIBOSYL
ISOMERASE A

(Streptomyces
sp. Mg1) 		PF00977
(His_biosynth) 		4 PHE A  60
LEU A  56
ALA A  59
THR A 168
 None
None
SO4  A 301 (-3.4A)
None
 0.93A 6f88A-4x9sA:
undetectable		 6f88A-4x9sA:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5byk SULFOTRANSFERASE

(Schistosoma
mansoni) 		no annotation 4 PHE A 165
LEU A 161
ALA A 164
THR A  18
 None
 1.00A 6f88A-5bykA:
undetectable		 6f88A-5bykA:
12.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5czz CRISPR-ASSOCIATED
ENDONUCLEASE CAS9

(Staphylococcus
aureus) 		PF13395
(HNH_4)
PF16592
(Cas9_REC) 		4 PHE A 715
LEU A 721
ALA A 724
ASN A 567
 None
 0.82A 6f88A-5czzA:
undetectable		 6f88A-5czzA:
6.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d50 REPRESSOR

(Salmonella
virus SPN1S) 		PF01381
(HTH_3) 		4 PHE A 149
ALA A 148
SER A 143
THR A 137
 None
 0.88A 6f88A-5d50A:
undetectable		 6f88A-5d50A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dt5 BETA-GLUCOSIDASE

(Exiguobacterium
antarcticum) 		PF00232
(Glyco_hydro_1) 		4 LEU A 140
ALA A 143
SER A 196
THR A 284
 None
 0.74A 6f88A-5dt5A:
undetectable		 6f88A-5dt5A:
10.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dz2 GERMACRADIENOL/GEOSM
IN SYNTHASE

(Streptomyces
coelicolor) 		no annotation 4 PHE A 277
LEU A 217
ALA A 281
THR A 201
 None
 0.81A 6f88A-5dz2A:
1.0		 6f88A-5dz2A:
13.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eid ANKYRIN REPEAT
DOMAIN-CONTAINING
PROTEIN 2

(Arabidopsis
thaliana) 		PF13637
(Ank_4) 		4 LEU A 336
ALA A 340
THR A 286
ASN A 314
 None
 0.93A 6f88A-5eidA:
undetectable		 6f88A-5eidA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eid ANKYRIN REPEAT
DOMAIN-CONTAINING
PROTEIN 2

(Arabidopsis
thaliana) 		PF13637
(Ank_4) 		4 LEU A 342
ALA A 340
THR A 286
ASN A 278
 None
 1.01A 6f88A-5eidA:
undetectable		 6f88A-5eidA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ema SORTING NEXIN-27

(Rattus
norvegicus) 		PF00595
(PDZ) 		4 PHE A  55
ALA A  90
SER A  49
ASN A 105
 None
 1.02A 6f88A-5emaA:
undetectable		 6f88A-5emaA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5epg ALDEHYDE OXIDASE

(Homo sapiens) 		PF00111
(Fer2)
PF00941
(FAD_binding_5)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2)
PF03450
(CO_deh_flav_C) 		4 PHE A 614
LEU A 612
ALA A 677
THR A 788
 None
 0.94A 6f88A-5epgA:
undetectable		 6f88A-5epgA:
4.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ft6 CYSTEINE DESULFURASE
CSDA

(Escherichia
coli) 		PF00266
(Aminotran_5) 		4 LEU A  76
ALA A 206
THR A  90
ASN A 122
 None
None
PLP  A1222 (-4.0A)
None
 0.99A 6f88A-5ft6A:
undetectable		 6f88A-5ft6A:
12.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i6e ACETYL-COA
CARBOXYLASE

(Saccharomyces
cerevisiae) 		PF08326
(ACC_central) 		4 PHE A1407
LEU A1408
SER A1422
THR A1338
 None
 0.95A 6f88A-5i6eA:
0.7		 6f88A-5i6eA:
8.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5irm UNCHARACTERIZED
PROTEIN

(Oryctolagus
cuniculus) 		PF05729
(NACHT)
PF13516
(LRR_6) 		4 PHE A 610
LEU A 691
ALA A 687
THR A 491
 None
 0.88A 6f88A-5irmA:
undetectable		 6f88A-5irmA:
7.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iud DNA POLYMERASE ALPHA
CATALYTIC SUBUNIT

(Homo sapiens) 		PF00136
(DNA_pol_B)
PF03104
(DNA_pol_B_exo1) 		4 PHE A 796
LEU A 792
ALA A 795
ASN A 873
 None
 0.82A 6f88A-5iudA:
undetectable		 6f88A-5iudA:
6.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jjc CYSTEINE SYNTHASE

(Brucella
abortus) 		PF00291
(PALP) 		4 PHE A 246
LEU A 243
ALA A 189
SER A 184
 None
None
None
LLP  A  42 ( 2.6A)
 0.86A 6f88A-5jjcA:
undetectable		 6f88A-5jjcA:
15.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l9w ACETOPHENONE
CARBOXYLASE DELTA
SUBUNIT

(Aromatoleum
aromaticum) 		PF02538
(Hydantoinase_B) 		4 LEU A 349
ALA A 308
THR A 506
ASN A 394
 None
None
K  A 703 ( 4.4A)
None
 0.89A 6f88A-5l9wA:
0.3		 6f88A-5l9wA:
8.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lc5 NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
4

(Bos taurus) 		PF00361
(Proton_antipo_M)
PF01059
(Oxidored_q5_N) 		4 LEU M 326
ALA M 362
SER M 407
THR M 414
 None
 0.98A 6f88A-5lc5M:
undetectable		 6f88A-5lc5M:
10.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5liv CYTOCHROME P450
CYP260A1,CYTOCHROME
P450 CYP260A1

(Sorangium
cellulosum) 		PF00067
(p450) 		5 PHE A 114
LEU A 119
ALA A 124
SER A 275
THR A 283
 None
None
HEM  A 501 (-3.9A)
HEM  A 501 ( 3.8A)
GOL  A 502 (-4.0A)
 0.49A 6f88A-5livA:
67.0		 6f88A-5livA:
61.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lq8 PUTATIVE PHOSPHONATE
BINDING PROTEIN FOR
ABC TRANSPORTER

(Prochlorococcus
marinus) 		no annotation 4 PHE A 119
LEU A 114
ALA A 172
THR A 200
 None
 0.94A 6f88A-5lq8A:
undetectable		 6f88A-5lq8A:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5sv9 BOR1P BORON
TRANSPORTER

(Saccharomyces
mikatae) 		PF00955
(HCO3_cotransp) 		4 LEU A  60
ALA A  64
SER A 413
ASN A 171
 None
 1.00A 6f88A-5sv9A:
undetectable		 6f88A-5sv9A:
10.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5thg I-ONUI_E-HCCR5

(synthetic
construct) 		PF00961
(LAGLIDADG_1) 		4 PHE A 150
LEU A 146
ALA A 149
THR A  32
 None
 0.87A 6f88A-5thgA:
undetectable		 6f88A-5thgA:
13.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tiw SULFOTRANSFERASE

(Schistosoma
haematobium) 		no annotation 4 PHE A 174
LEU A 170
ALA A 173
THR A  33
 None
 0.97A 6f88A-5tiwA:
undetectable		 6f88A-5tiwA:
9.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uso PROTECTION OF
TELOMERES PROTEIN 1

(Schizosaccharomyces
pombe) 		no annotation 4 PHE A  19
LEU A   8
ALA A  21
SER A  66
 None
 0.83A 6f88A-5usoA:
undetectable		 6f88A-5usoA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y30 LEUCINE-RICH
GLIOMA-INACTIVATED
PROTEIN 1

(Homo sapiens) 		no annotation 4 PHE A 111
ALA A 110
SER A 131
ASN A 125
 None
 0.69A 6f88A-5y30A:
undetectable		 6f88A-5y30A:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y4d ANKYRIN-1,ANKYRIN-2,
ANKYRIN-2

(Homo sapiens;
Mus musculus) 		PF00023
(Ank)
PF12796
(Ank_2)
PF13637
(Ank_4) 		4 LEU A2483
ALA A2488
THR A2433
ASN A2461
 None
 0.96A 6f88A-5y4dA:
undetectable		 6f88A-5y4dA:
7.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y4f ANKYRIN-2

(Homo sapiens) 		PF00023
(Ank)
PF12796
(Ank_2)
PF13637
(Ank_4)
PF13857
(Ank_5) 		4 LEU A 482
ALA A 487
THR A 432
ASN A 460
 None
 0.92A 6f88A-5y4fA:
undetectable		 6f88A-5y4fA:
9.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z2n -

(-) 		no annotation 4 LEU B 100
ALA B 105
THR B  50
ASN B  78
 None
 0.95A 6f88A-5z2nB:
undetectable		 6f88A-5z2nB:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6f85 CYTOCHROME P450
CYP260A1

(Sorangium
cellulosum) 		no annotation 6 PHE A  64
LEU A  69
ALA A  74
SER A 225
THR A 233
ASN A 276
 None
HIS  A 502 (-4.9A)
HEM  A 501 (-3.8A)
HEM  A 501 ( 4.0A)
HIS  A 502 ( 3.5A)
HEM  A 501 (-4.3A)
 0.34A 6f88A-6f85A:
67.2		 6f88A-6f85A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fm7 BETA-LACTAMASE

(Aeromonas
enteropelogenes) 		no annotation 4 PHE A 232
LEU A 180
ALA A 235
THR A  73
 None
 1.00A 6f88A-6fm7A:
undetectable		 6f88A-6fm7A:
23.08