SIMILAR PATTERNS OF AMINO ACIDS FOR 6F7L_B_ACTB505

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a0c XYLOSE ISOMERASE

(Thermoanaerobacterium
thermosulfurigenes) 		PF01261
(AP_endonuc_2) 		3 HIS A 100
ASN A 142
LEU A 143
 None
 0.86A 6f7lB-1a0cA:
undetectable		 6f7lB-1a0cA:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a0d XYLOSE ISOMERASE

(Geobacillus
stearothermophilus) 		PF01261
(AP_endonuc_2) 		3 HIS A  98
ASN A 140
LEU A 141
 None
 0.81A 6f7lB-1a0dA:
0.0		 6f7lB-1a0dA:
24.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a0e XYLOSE ISOMERASE

(Thermotoga
neapolitana) 		PF01261
(AP_endonuc_2) 		3 HIS A 100
ASN A 142
LEU A 143
 None
 0.88A 6f7lB-1a0eA:
undetectable		 6f7lB-1a0eA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e2t N-HYDROXYARYLAMINE
O-ACETYLTRANSFERASE

(Salmonella
enterica) 		PF00797
(Acetyltransf_2) 		3 HIS A 208
ASN A  33
LEU A  30
 None
 0.89A 6f7lB-1e2tA:
undetectable		 6f7lB-1e2tA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ei6 PHOSPHONOACETATE
HYDROLASE

(Pseudomonas
fluorescens) 		PF01663
(Phosphodiest) 		3 HIS A 405
ASN A 404
LEU A 403
 None
 0.83A 6f7lB-1ei6A:
undetectable		 6f7lB-1ei6A:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gu1 3-DEHYDROQUINATE
DEHYDRATASE

(Streptomyces
coelicolor) 		PF01220
(DHquinase_II) 		3 HIS A  73
ASN A  72
LEU A  71
 None
 0.87A 6f7lB-1gu1A:
undetectable		 6f7lB-1gu1A:
16.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lrz FACTOR ESSENTIAL FOR
EXPRESSION OF
METHICILLIN
RESISTANCE

(Staphylococcus
aureus) 		PF02388
(FemAB) 		3 HIS A 356
ASN A 355
LEU A 354
 None
 0.91A 6f7lB-1lrzA:
undetectable		 6f7lB-1lrzA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ml8 HYPOTHETICAL PROTEIN
(CRP REGION)

(Escherichia
coli) 		PF02566
(OsmC) 		3 HIS A  84
ASN A  86
LEU A  87
 None
 0.82A 6f7lB-1ml8A:
undetectable		 6f7lB-1ml8A:
14.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nsa PROCARBOXYPEPTIDASE
B

(Sus scrofa) 		PF00246
(Peptidase_M14)
PF02244
(Propep_M14) 		3 HIS A  95
ASN A 302
LEU A 305
 None
 0.90A 6f7lB-1nsaA:
undetectable		 6f7lB-1nsaA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nyq THREONYL-TRNA
SYNTHETASE 1

(Staphylococcus
aureus) 		PF00587
(tRNA-synt_2b)
PF02824
(TGS)
PF03129
(HGTP_anticodon)
PF07973
(tRNA_SAD) 		3 HIS A 339
ASN A 335
LEU A 383
 None
None
TSB  A1002 (-4.6A)
 0.90A 6f7lB-1nyqA:
undetectable		 6f7lB-1nyqA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o7d LYSOSOMAL
ALPHA-MANNOSIDASE

(Bos taurus) 		PF01074
(Glyco_hydro_38) 		3 HIS A 311
ASN A  64
LEU A  63
 None
 0.86A 6f7lB-1o7dA:
undetectable		 6f7lB-1o7dA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p1v SUPEROXIDE DISMUTASE
[CU-ZN]

(Homo sapiens) 		PF00080
(Sod_Cu) 		3 HIS A  80
ASN A  65
LEU A  67
 ZN  A 202 (-3.0A)
None
None
 0.89A 6f7lB-1p1vA:
undetectable		 6f7lB-1p1vA:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u0n PLATELET
GLYCOPROTEIN IB

(Homo sapiens) 		PF01462
(LRRNT)
PF13855
(LRR_8) 		3 HIS D  37
ASN D  61
LEU D  60
 None
 0.71A 6f7lB-1u0nD:
undetectable		 6f7lB-1u0nD:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1um2 ENDONUCLEASE PI-SCEI

(Saccharomyces
cerevisiae) 		PF05203
(Hom_end_hint)
PF05204
(Hom_end) 		3 HIS A 736
ASN A 737
LEU A 719
 None
 0.84A 6f7lB-1um2A:
undetectable		 6f7lB-1um2A:
24.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vsl PROTEIN (INTEGRASE)

(Rous sarcoma
virus) 		PF00665
(rve) 		3 HIS A 198
ASN A 197
LEU A 196
 None
 0.76A 6f7lB-1vslA:
undetectable		 6f7lB-1vslA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z7a CONSERVED
HYPOTHETICAL PROTEIN

(Pseudomonas
aeruginosa) 		PF01522
(Polysacc_deac_1) 		3 HIS A 259
ASN A  34
LEU A  33
 None
 0.89A 6f7lB-1z7aA:
undetectable		 6f7lB-1z7aA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a2a DEATH-ASSOCIATED
PROTEIN KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		3 HIS A 243
ASN A 292
LEU A 293
 None
 0.71A 6f7lB-2a2aA:
undetectable		 6f7lB-2a2aA:
24.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aip PROTEIN C ACTIVATOR

(Agkistrodon
contortrix) 		PF00089
(Trypsin) 		3 HIS A  71
ASN A  72
LEU A  73
 None
 0.90A 6f7lB-2aipA:
undetectable		 6f7lB-2aipA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c0y PROCATHEPSIN S

(Homo sapiens) 		PF00112
(Peptidase_C1)
PF08246
(Inhibitor_I29) 		3 HIS A  64
ASN A  63
LEU A 246
 None
 0.88A 6f7lB-2c0yA:
undetectable		 6f7lB-2c0yA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e54 ACETYLORNITHINE
AMINOTRANSFERASE

(Thermotoga
maritima) 		PF00202
(Aminotran_3) 		3 HIS A  62
ASN A 272
LEU A 274
 None
 0.89A 6f7lB-2e54A:
undetectable		 6f7lB-2e54A:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g3n ALPHA-GLUCOSIDASE

(Sulfolobus
solfataricus) 		PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2) 		3 HIS A 252
ASN A 322
LEU A 319
 None
 0.83A 6f7lB-2g3nA:
undetectable		 6f7lB-2g3nA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2glx 1,5-ANHYDRO-D-FRUCTO
SE REDUCTASE

(Ensifer
adhaerens) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		3 HIS A  76
ASN A  73
LEU A 175
 NDP  A1500 (-4.1A)
NDP  A1500 (-3.4A)
None
 0.74A 6f7lB-2glxA:
undetectable		 6f7lB-2glxA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hls PROTEIN DISULFIDE
OXIDOREDUCTASE

(Aeropyrum
pernix) 		PF13192
(Thioredoxin_3) 		3 HIS A  31
ASN A  68
LEU A  67
 None
 0.69A 6f7lB-2hlsA:
undetectable		 6f7lB-2hlsA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ivf ETHYLBENZENE
DEHYDROGENASE
ALPHA-SUBUNIT

(Aromatoleum
aromaticum) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding) 		3 HIS A 841
ASN A 896
LEU A 935
 None
 0.89A 6f7lB-2ivfA:
undetectable		 6f7lB-2ivfA:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jwp MALECTIN

(Xenopus laevis) 		PF11721
(Malectin) 		3 HIS A 109
ASN A 107
LEU A 153
 None
 0.82A 6f7lB-2jwpA:
undetectable		 6f7lB-2jwpA:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nyg YOKD PROTEIN

(Bacillus
subtilis) 		PF02522
(Antibiotic_NAT) 		3 HIS A 130
ASN A 132
LEU A  75
 None
 0.62A 6f7lB-2nygA:
undetectable		 6f7lB-2nygA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o1b AMINOTRANSFERASE,
CLASS I

(Staphylococcus
aureus) 		PF00155
(Aminotran_1_2) 		3 HIS A 280
ASN A 279
LEU A 278
 None
 0.90A 6f7lB-2o1bA:
undetectable		 6f7lB-2o1bA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ws9 P1

(Equine rhinitis
A virus) 		no annotation 3 HIS 1 202
ASN 1  47
LEU 1  48
 None
 0.78A 6f7lB-2ws91:
undetectable		 6f7lB-2ws91:
18.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zoa PHOSPHOHYDROLASE

(Klebsiella
aerogenes) 		PF00149
(Metallophos) 		3 HIS A 176
ASN A 174
LEU A 131
 None
 0.83A 6f7lB-2zoaA:
undetectable		 6f7lB-2zoaA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cl6 PUUE ALLANTOINASE

(Pseudomonas
fluorescens) 		PF01522
(Polysacc_deac_1) 		3 HIS A 259
ASN A  34
LEU A  33
 None
 0.90A 6f7lB-3cl6A:
undetectable		 6f7lB-3cl6A:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gyx ADENYLYLSULFATE
REDUCTASE

(Desulfovibrio
gigas) 		PF00890
(FAD_binding_2) 		3 HIS A 220
ASN A 213
LEU A 214
 None
 0.77A 6f7lB-3gyxA:
9.7		 6f7lB-3gyxA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h9c METHIONYL-TRNA
SYNTHETASE

(Escherichia
coli) 		PF09334
(tRNA-synt_1g) 		3 HIS A 349
ASN A 348
LEU A 347
 None
 0.91A 6f7lB-3h9cA:
undetectable		 6f7lB-3h9cA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hn0 NITRATE TRANSPORT
PROTEIN

(Parabacteroides
distasonis) 		no annotation 3 HIS A 191
ASN A 190
LEU A 189
 None
 0.91A 6f7lB-3hn0A:
undetectable		 6f7lB-3hn0A:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j9t V-TYPE PROTON ATPASE
SUBUNIT H

(Saccharomyces
cerevisiae) 		PF03224
(V-ATPase_H_N)
PF11698
(V-ATPase_H_C) 		3 HIS P 456
ASN P 455
LEU P 454
 None
 0.90A 6f7lB-3j9tP:
undetectable		 6f7lB-3j9tP:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jca INTEGRASE

(Mouse mammary
tumor virus) 		PF00552
(IN_DBD_C)
PF00665
(rve)
PF02022
(Integrase_Zn) 		3 HIS A 193
ASN A 192
LEU A 191
 None
 0.84A 6f7lB-3jcaA:
undetectable		 6f7lB-3jcaA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jcu CHLOROPHYLL A-B
BINDING PROTEIN 26
KD (CP26)

(Spinacia
oleracea) 		PF00504
(Chloroa_b-bind) 		3 HIS S 221
ASN S 229
LEU S 230
 CLA  S 614 ( 3.4A)
CLA  S 614 ( 3.7A)
CLA  S 613 (-3.7A)
 0.89A 6f7lB-3jcuS:
undetectable		 6f7lB-3jcuS:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ky7 TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE

(Staphylococcus
aureus) 		PF01746
(tRNA_m1G_MT) 		3 HIS A  19
ASN A  18
LEU A  17
 None
 0.87A 6f7lB-3ky7A:
undetectable		 6f7lB-3ky7A:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l8k DIHYDROLIPOYL
DEHYDROGENASE

(Sulfolobus
solfataricus) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		3 HIS A 197
ASN A 225
LEU A 224
 None
 0.75A 6f7lB-3l8kA:
10.6		 6f7lB-3l8kA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3loy COPPER AMINE OXIDASE

(Ogataea angusta) 		PF01179
(Cu_amine_oxid) 		3 HIS A 403
ASN A 391
LEU A 390
 GOL  A 639 ( 4.1A)
GOL  A 639 (-3.2A)
None
 0.71A 6f7lB-3loyA:
undetectable		 6f7lB-3loyA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m99 UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 8

(Saccharomyces
cerevisiae) 		PF00443
(UCH)
PF02148
(zf-UBP) 		3 HIS A  33
ASN A  32
LEU A  31
 None
 0.88A 6f7lB-3m99A:
undetectable		 6f7lB-3m99A:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mcp GLUCOKINASE

(Parabacteroides
distasonis) 		PF00480
(ROK) 		3 HIS A 362
ASN A 361
LEU A 360
 None
 0.90A 6f7lB-3mcpA:
undetectable		 6f7lB-3mcpA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r9p ACKA

(Mycobacterium
avium) 		PF00871
(Acetate_kinase) 		3 HIS A 259
ASN A 258
LEU A 257
 None
 0.90A 6f7lB-3r9pA:
undetectable		 6f7lB-3r9pA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s6o POLYSACCHARIDE
DEACETYLASE FAMILY
PROTEIN

(Burkholderia
pseudomallei) 		PF01522
(Polysacc_deac_1) 		3 HIS A 263
ASN A  36
LEU A  35
 None
 0.84A 6f7lB-3s6oA:
undetectable		 6f7lB-3s6oA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s7w EIGHT-HEME NITRITE
REDUCTASE

(Thioalkalivibrio
nitratireducens) 		PF02335
(Cytochrom_C552) 		3 HIS A 223
ASN A 222
LEU A 221
 None
 0.83A 6f7lB-3s7wA:
undetectable		 6f7lB-3s7wA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sag EXOSOME COMPONENT 10

(Homo sapiens) 		PF00570
(HRDC)
PF01612
(DNA_pol_A_exo1) 		3 HIS A 264
ASN A 263
LEU A 262
 HIS  A 264 ( 1.0A)
ASN  A 263 ( 0.6A)
LEU  A 262 ( 0.6A)
 0.89A 6f7lB-3sagA:
undetectable		 6f7lB-3sagA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tqx 2-AMINO-3-KETOBUTYRA
TE COENZYME A LIGASE

(Coxiella
burnetii) 		PF00155
(Aminotran_1_2) 		3 HIS A 343
ASN A 339
LEU A 336
 None
 0.90A 6f7lB-3tqxA:
undetectable		 6f7lB-3tqxA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ue9 ADENYLOSUCCINATE
SYNTHETASE

(Burkholderia
thailandensis) 		PF00709
(Adenylsucc_synt) 		3 HIS A 178
ASN A 174
LEU A 171
 None
 0.83A 6f7lB-3ue9A:
undetectable		 6f7lB-3ue9A:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ujh GLUCOSE-6-PHOSPHATE
ISOMERASE

(Toxoplasma
gondii) 		PF00342
(PGI) 		3 HIS A 110
ASN A 115
LEU A 117
 None
 0.81A 6f7lB-3ujhA:
undetectable		 6f7lB-3ujhA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w0d ELASTASE INHIBITOR
AFUEI

(Aspergillus
fumigatus) 		PF11720
(Inhibitor_I78) 		3 HIS A  66
ASN A  53
LEU A  52
 None
 0.85A 6f7lB-3w0dA:
undetectable		 6f7lB-3w0dA:
9.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wgo MESO-DIAMINOPIMELATE
DEHYDROGENASE

(Clostridium
tetani) 		PF16654
(DAPDH_C) 		3 HIS A 244
ASN A 243
LEU A 242
 None
 0.88A 6f7lB-3wgoA:
3.6		 6f7lB-3wgoA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zg8 PENICILLIN-BINDING
PROTEIN 4

(Listeria
monocytogenes) 		PF00905
(Transpeptidase)
PF00912
(Transgly) 		3 HIS B 631
ASN B 635
LEU B 638
 None
 0.55A 6f7lB-3zg8B:
undetectable		 6f7lB-3zg8B:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ade SUCCINYLORNITHINE
TRANSAMINASE

(Escherichia
coli) 		PF00202
(Aminotran_3) 		3 HIS A  73
ASN A 285
LEU A 287
 None
 0.73A 6f7lB-4adeA:
undetectable		 6f7lB-4adeA:
24.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b98 BETA-ALANINE--PYRUVA
TE TRANSAMINASE

(Pseudomonas
aeruginosa) 		PF00202
(Aminotran_3) 		3 HIS A 113
ASN A 112
LEU A 111
 None
 0.88A 6f7lB-4b98A:
undetectable		 6f7lB-4b98A:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bpu DNA PRIMASE LARGE
SUBUNIT

(Homo sapiens) 		PF04104
(DNA_primase_lrg) 		3 HIS B 252
ASN B 251
LEU B 250
 None
 0.88A 6f7lB-4bpuB:
undetectable		 6f7lB-4bpuB:
24.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bpx DNA POLYMERASE ALPHA
CATALYTIC SUBUNIT,
DNA PRIMASE LARGE
SUBUNIT

(Homo sapiens) 		PF04104
(DNA_primase_lrg) 		3 HIS B 252
ASN B 251
LEU B 250
 None
 0.89A 6f7lB-4bpxB:
undetectable		 6f7lB-4bpxB:
23.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bpz ENDO-1,3-BETA-GLUCAN
ASE, FAMILY GH16

(Zobellia
galactanivorans) 		PF00722
(Glyco_hydro_16) 		3 HIS A 288
ASN A 299
LEU A 300
 GLC  A 401 ( 3.3A)
None
None
 0.88A 6f7lB-4bpzA:
undetectable		 6f7lB-4bpzA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dpk MALONYL-COA/SUCCINYL
-COA REDUCTASE

(Sulfurisphaera
tokodaii) 		PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC) 		3 HIS A 129
ASN A 127
LEU A 122
 None
 0.88A 6f7lB-4dpkA:
4.7		 6f7lB-4dpkA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e5t MANDELATE RACEMASE /
MUCONATE LACTONIZING
ENZYME, C-TERMINAL
DOMAIN PROTEIN

(Labrenzia
alexandrii) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		3 HIS A 315
ASN A 288
LEU A 289
 None
 0.65A 6f7lB-4e5tA:
undetectable		 6f7lB-4e5tA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f7a PUTATIVE
UNCHARACTERIZED
PROTEIN

(Bacteroides
vulgatus) 		PF12741
(SusD-like) 		3 HIS A  80
ASN A  79
LEU A  78
 None
 0.90A 6f7lB-4f7aA:
undetectable		 6f7lB-4f7aA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fw1 INTEGRASE

(Rous sarcoma
virus) 		PF00552
(IN_DBD_C)
PF00665
(rve) 		3 HIS A 198
ASN A 197
LEU A 196
 None
 0.85A 6f7lB-4fw1A:
undetectable		 6f7lB-4fw1A:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g1u HEMIN IMPORT
ATP-BINDING PROTEIN
HMUV

(Yersinia pestis) 		PF00005
(ABC_tran) 		3 HIS C  69
ASN C  74
LEU C  75
 None
 0.84A 6f7lB-4g1uC:
undetectable		 6f7lB-4g1uC:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4huj UNCHARACTERIZED
PROTEIN

(Sinorhizobium
meliloti) 		PF03807
(F420_oxidored) 		3 HIS A 153
ASN A 152
LEU A 177
 None
 0.81A 6f7lB-4hujA:
3.5		 6f7lB-4hujA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4isy CYSTEINE DESULFURASE

(Mycobacterium
tuberculosis) 		PF00266
(Aminotran_5) 		3 HIS A 301
ASN A 288
LEU A 287
 None
 0.84A 6f7lB-4isyA:
undetectable		 6f7lB-4isyA:
24.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jeu SYNTAXIN-BINDING
PROTEIN 1

(Rattus
norvegicus) 		PF00995
(Sec1) 		3 HIS A 445
ASN A 442
LEU A 582
 None
 0.90A 6f7lB-4jeuA:
undetectable		 6f7lB-4jeuA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mk0 BETA-ADRENERGIC
RECEPTOR KINASE 1

(Homo sapiens) 		PF00069
(Pkinase)
PF00169
(PH)
PF00615
(RGS) 		3 HIS A  75
ASN A  74
LEU A  73
 None
 0.82A 6f7lB-4mk0A:
undetectable		 6f7lB-4mk0A:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ns1 PURINE NUCLEOSIDE
PHOSPHORYLASE

(Porphyromonas
gingivalis) 		PF01048
(PNP_UDP_1) 		3 HIS A 148
ASN A 150
LEU A 152
 None
 0.70A 6f7lB-4ns1A:
undetectable		 6f7lB-4ns1A:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o1r REPLICATIVE DNA
HELICASE

(Nostoc
punctiforme) 		PF14890
(Intein_splicing) 		3 HIS A 138
ASN A 129
LEU A  33
 None
 0.68A 6f7lB-4o1rA:
undetectable		 6f7lB-4o1rA:
15.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p9u FATTY ACID
METABOLISM REGULATOR
PROTEIN

(Vibrio cholerae) 		no annotation 3 HIS E 195
ASN E 120
LEU E 119
 None
 0.83A 6f7lB-4p9uE:
undetectable		 6f7lB-4p9uE:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tn0 UPF0141 PROTEIN YJDB

(Campylobacter
jejuni) 		PF00884
(Sulfatase) 		3 HIS A 343
ASN A 342
LEU A 341
 None
 0.86A 6f7lB-4tn0A:
undetectable		 6f7lB-4tn0A:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v1j FIMBRIAL PROTEIN

(Neisseria
meningitidis) 		PF00114
(Pilin) 		3 HIS A  33
ASN A  32
LEU A  31
 EDO  A1145 (-4.0A)
None
None
 0.87A 6f7lB-4v1jA:
undetectable		 6f7lB-4v1jA:
16.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wid RHUL123

(Macacine
betaherpesvirus
3) 		PF07340
(Herpes_IE1) 		3 HIS A 245
ASN A 242
LEU A 273
 None
 0.81A 6f7lB-4widA:
undetectable		 6f7lB-4widA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wjm RIBOKINASE:CARBOHYDR
ATE KINASE, PFKB

(Brucella
abortus) 		PF00294
(PfkB) 		3 HIS A 229
ASN A 228
LEU A 207
 None
 0.78A 6f7lB-4wjmA:
3.8		 6f7lB-4wjmA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wm0 XYLOSIDE
XYLOSYLTRANSFERASE 1

(Mus musculus) 		PF01501
(Glyco_transf_8) 		3 HIS A  99
ASN A 137
LEU A 136
 None
 0.69A 6f7lB-4wm0A:
undetectable		 6f7lB-4wm0A:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xia D-XYLOSE ISOMERASE

(Arthrobacter
sp. NRRL B3728) 		PF01261
(AP_endonuc_2) 		3 HIS A  53
ASN A  91
LEU A  92
 SOR  A 400 (-4.0A)
None
None
 0.89A 6f7lB-4xiaA:
undetectable		 6f7lB-4xiaA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xsc THYMIDYLATE SYNTHASE

(Human
alphaherpesvirus
3) 		PF00303
(Thymidylat_synt) 		3 HIS A 249
ASN A 248
LEU A 247
 None
 0.78A 6f7lB-4xscA:
undetectable		 6f7lB-4xscA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yio SUPEROXIDE DISMUTASE

(Streptococcus
thermophilus) 		PF00081
(Sod_Fe_N)
PF02777
(Sod_Fe_C) 		3 HIS A  80
ASN A  79
LEU A  78
 FE  A 301 (-3.3A)
None
None
 0.88A 6f7lB-4yioA:
undetectable		 6f7lB-4yioA:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yip SUPEROXIDE DISMUTASE
[MN/FE]

(Streptococcus
mutans) 		PF00081
(Sod_Fe_N)
PF02777
(Sod_Fe_C) 		3 HIS A  80
ASN A  79
LEU A  78
 FE  A 301 (-3.4A)
None
None
 0.90A 6f7lB-4yipA:
undetectable		 6f7lB-4yipA:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zgq CELL DIVISION CYCLE
PROTEIN 123

(Schizosaccharomyces
pombe) 		PF07065
(D123) 		3 HIS A 138
ASN A 137
LEU A 136
 None
 0.87A 6f7lB-4zgqA:
undetectable		 6f7lB-4zgqA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zhj MG-CHELATASE SUBUNIT
CHLH

(Synechocystis
sp. PCC 6803) 		PF02514
(CobN-Mg_chel)
PF11965
(DUF3479) 		3 HIS A 608
ASN A 607
LEU A 606
 None
 0.88A 6f7lB-4zhjA:
2.8		 6f7lB-4zhjA:
15.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bth DECAPPING NUCLEASE
RAI1

(Candida
albicans) 		PF08652
(RAI1) 		3 HIS A 241
ASN A 240
LEU A 239
 None
 0.83A 6f7lB-5bthA:
undetectable		 6f7lB-5bthA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cvo UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 46

(Homo sapiens) 		PF00443
(UCH) 		3 HIS B 122
ASN B 126
LEU B 129
 None
 0.79A 6f7lB-5cvoB:
undetectable		 6f7lB-5cvoB:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cz2 POL POLYPROTEIN

(Mouse mammary
tumor virus) 		PF00665
(rve) 		3 HIS A 193
ASN A 192
LEU A 191
 None
 0.88A 6f7lB-5cz2A:
undetectable		 6f7lB-5cz2A:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dx9 TREHALOSE-6-PHOSPHAT
E PHOSPHATASE

(Cryptococcus
neoformans) 		PF02358
(Trehalose_PPase) 		3 HIS A 140
ASN A 178
LEU A 179
 T6P  A 402 (-3.7A)
T6P  A 402 (-3.5A)
BME  A 403 ( 4.3A)
 0.90A 6f7lB-5dx9A:
2.6		 6f7lB-5dx9A:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5efv PHI ETA ORF 56-LIKE
PROTEIN

(Staphylococcus
virus 11) 		no annotation 3 HIS A 186
ASN A 206
LEU A 229
 None
 0.87A 6f7lB-5efvA:
undetectable		 6f7lB-5efvA:
19.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ejk GAG-PRO-POL
POLYPROTEIN

(Rous sarcoma
virus) 		PF00552
(IN_DBD_C)
PF00665
(rve)
PF02022
(Integrase_Zn) 		3 HIS A 198
ASN A 197
LEU A 196
 None
 0.90A 6f7lB-5ejkA:
undetectable		 6f7lB-5ejkA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gr1 1,4-ALPHA-GLUCAN
BRANCHING ENZYME
GLGB

(Cyanothece sp.
ATCC 51142) 		PF00128
(Alpha-amylase)
PF02806
(Alpha-amylase_C)
PF02922
(CBM_48) 		3 HIS A  84
ASN A  83
LEU A  82
 None
 0.85A 6f7lB-5gr1A:
undetectable		 6f7lB-5gr1A:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h3h ABHYDROLASE
DOMAIN-CONTAINING
PROTEIN

(Exiguobacterium
antarcticum) 		PF00561
(Abhydrolase_1)
PF08386
(Abhydrolase_4) 		3 HIS A 109
ASN A 108
LEU A 107
 None
 0.90A 6f7lB-5h3hA:
undetectable		 6f7lB-5h3hA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h64 SERINE/THREONINE-PRO
TEIN KINASE MTOR

(Homo sapiens) 		PF00454
(PI3_PI4_kinase)
PF02259
(FAT)
PF02260
(FATC)
PF08771
(FRB_dom)
PF11865
(DUF3385) 		3 HIS A1206
ASN A1205
LEU A1199
 None
 0.80A 6f7lB-5h64A:
undetectable		 6f7lB-5h64A:
10.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hxz BARBITURASE

(Rhodococcus
erythropolis) 		PF09663
(Amido_AtzD_TrzD) 		3 HIS A 157
ASN A 245
LEU A 113
 None
 0.89A 6f7lB-5hxzA:
undetectable		 6f7lB-5hxzA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hy4 RING-OPENING
AMIDOHYDROLASE

(Frankia sp.
Eul1b) 		PF09663
(Amido_AtzD_TrzD) 		3 HIS A 172
ASN A 266
LEU A 128
 None
 0.84A 6f7lB-5hy4A:
undetectable		 6f7lB-5hy4A:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j1q CARBOXYPEPTIDASE B

(Sus scrofa) 		PF00246
(Peptidase_M14) 		3 HIS A  95
ASN A 302
LEU A 305
 None
 0.84A 6f7lB-5j1qA:
1.4		 6f7lB-5j1qA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kiv PROTEIN-ADP-RIBOSE
HYDROLASE

(Staphylococcus
aureus) 		PF01661
(Macro) 		3 HIS A  70
ASN A  69
LEU A  68
 None
None
EOH  A 305 ( 3.4A)
 0.87A 6f7lB-5kivA:
undetectable		 6f7lB-5kivA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5msw THIOESTER REDUCTASE
DOMAIN-CONTAINING
PROTEIN

(Segniliparus
rugosus) 		PF00501
(AMP-binding)
PF00550
(PP-binding) 		3 HIS A 694
ASN A 731
LEU A 732
 None
 0.85A 6f7lB-5mswA:
undetectable		 6f7lB-5mswA:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u0p MEDIATOR COMPLEX
SUBUNIT 14

(Schizosaccharomyces
pombe) 		PF08638
(Med14) 		3 HIS N 159
ASN N 162
LEU N 161
 None
 0.84A 6f7lB-5u0pN:
undetectable		 6f7lB-5u0pN:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vsl RADICAL S-ADENOSYL
METHIONINE
DOMAIN-CONTAINING
PROTEIN 2

(Mus musculus) 		PF04055
(Radical_SAM)
PF13353
(Fer4_12) 		3 HIS A  79
ASN A  77
LEU A 303
 None
 0.88A 6f7lB-5vslA:
undetectable		 6f7lB-5vslA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y4j XYLOSE ISOMERASE

(Streptomyces
rubiginosus) 		PF01261
(AP_endonuc_2) 		3 HIS A  54
ASN A  92
LEU A  93
 XYL  A 402 (-3.8A)
None
None
 0.88A 6f7lB-5y4jA:
undetectable		 6f7lB-5y4jA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6az1 RIBOSOMAL PROTEIN
S4E

(Leishmania
donovani) 		no annotation 3 HIS E 231
ASN E 230
LEU E 229
 None
 0.90A 6f7lB-6az1E:
undetectable		 6f7lB-6az1E:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bzc GLUCOSE-6-PHOSPHATE
ISOMERASE

(Elizabethkingia
anophelis) 		no annotation 3 HIS A 171
ASN A 409
LEU A 476
 None
 0.72A 6f7lB-6bzcA:
undetectable		 6f7lB-6bzcA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c3p ATP-BINDING CASSETTE
SUB-FAMILY C MEMBER
8

(Homo sapiens) 		no annotation 3 HIS E 125
ASN E 223
LEU E 225
 None
 0.90A 6f7lB-6c3pE:
undetectable		 6f7lB-6c3pE:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6exv DNA-DIRECTED RNA
POLYMERASES I, II,
AND III SUBUNIT
RPABC1

(Sus scrofa) 		no annotation 3 HIS E  64
ASN E  65
LEU E  27
 None
 0.88A 6f7lB-6exvE:
undetectable		 6f7lB-6exvE:
undetectable