SIMILAR PATTERNS OF AMINO ACIDS FOR 6F7L_B_ACTB503_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b7g PROTEIN
(GLYCERALDEHYDE
3-PHOSPHATE
DEHYDROGENASE)


(Sulfolobus
solfataricus)
PF01113
(DapB_N)
PF02800
(Gp_dh_C)
3 VAL O 157
GLU O 158
ILE O 225
None
0.63A 6f7lB-1b7gO:
4.3
6f7lB-1b7gO:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bbu PROTEIN (LYSYL-TRNA
SYNTHETASE)


(Escherichia
coli)
PF00152
(tRNA-synt_2)
PF01336
(tRNA_anti-codon)
3 VAL A 361
GLU A 362
ILE A 370
None
0.49A 6f7lB-1bbuA:
undetectable
6f7lB-1bbuA:
23.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bft NUCLEAR FACTOR
NF-KAPPA-B P65


(Mus musculus)
PF16179
(RHD_dimer)
3 VAL A 226
GLU A 225
ILE A 250
None
0.65A 6f7lB-1bftA:
undetectable
6f7lB-1bftA:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bja TRANSCRIPTION
REGULATORY PROTEIN
MOTA


(Escherichia
virus T4)
PF09114
(MotA_activ)
3 VAL A  62
GLU A  63
ILE A  26
None
0.63A 6f7lB-1bjaA:
undetectable
6f7lB-1bjaA:
11.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dll TETANUS TOXIN

(Clostridium
tetani)
PF07951
(Toxin_R_bind_C)
PF07953
(Toxin_R_bind_N)
3 VAL A 933
GLU A 932
ILE A 923
None
0.59A 6f7lB-1dllA:
undetectable
6f7lB-1dllA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e1t LYSYL-TRNA
SYNTHETASE, HEAT
INDUCIBLE


(Escherichia
coli)
PF00152
(tRNA-synt_2)
PF01336
(tRNA_anti-codon)
3 VAL A 361
GLU A 362
ILE A 370
None
0.52A 6f7lB-1e1tA:
undetectable
6f7lB-1e1tA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ex0 COAGULATION FACTOR
XIII A CHAIN


(Homo sapiens)
PF00868
(Transglut_N)
PF00927
(Transglut_C)
PF01841
(Transglut_core)
3 VAL A 452
GLU A 453
ILE A 440
None
0.65A 6f7lB-1ex0A:
undetectable
6f7lB-1ex0A:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hh2 N UTILIZATION
SUBSTANCE PROTEIN A


(Thermotoga
maritima)
PF00575
(S1)
PF08529
(NusA_N)
PF13184
(KH_5)
3 VAL P  23
GLU P  22
ILE P  18
None
0.64A 6f7lB-1hh2P:
undetectable
6f7lB-1hh2P:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i7q TRPG

(Serratia
marcescens)
PF00117
(GATase)
3 VAL B  39
GLU B  38
ILE B  35
None
0.65A 6f7lB-1i7qB:
undetectable
6f7lB-1i7qB:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i9a ISOPENTENYL-DIPHOSPH
ATE DELTA-ISOMERASE


(Escherichia
coli)
PF00293
(NUDIX)
3 VAL A 136
GLU A 135
ILE A 131
None
0.66A 6f7lB-1i9aA:
undetectable
6f7lB-1i9aA:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1if1 PROTEIN (INTERFERON
REGULATORY FACTOR 1)


(Mus musculus)
PF00605
(IRF)
3 VAL A 106
GLU A  93
ILE A  33
None
0.60A 6f7lB-1if1A:
undetectable
6f7lB-1if1A:
11.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ii8 RAD50 ABC-ATPASE
RAD50 ABC-ATPASE


(Pyrococcus
furiosus;
Pyrococcus
furiosus)
PF13476
(AAA_23)
PF13304
(AAA_21)
3 VAL A  19
GLU A  20
ILE B 867
None
0.64A 6f7lB-1ii8A:
undetectable
6f7lB-1ii8A:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ik6 PYRUVATE
DEHYDROGENASE


(Pyrobaculum
aerophilum)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C)
3 VAL A 274
GLU A 273
ILE A 260
None
0.66A 6f7lB-1ik6A:
undetectable
6f7lB-1ik6A:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j2b ARCHAEOSINE
TRNA-GUANINE
TRANSGLYCOSYLASE


(Pyrococcus
horikoshii)
PF01472
(PUA)
PF01702
(TGT)
PF14809
(TGT_C1)
PF14810
(TGT_C2)
3 VAL A  26
GLU A  25
ILE A  91
None
0.56A 6f7lB-1j2bA:
undetectable
6f7lB-1j2bA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ji5 DLP-1

(Bacillus
anthracis)
PF00210
(Ferritin)
3 VAL A   8
GLU A   7
ILE A 113
None
0.59A 6f7lB-1ji5A:
undetectable
6f7lB-1ji5A:
15.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jv1 GLCNAC1P
URIDYLTRANSFERASE
ISOFORM 1: AGX1


(Homo sapiens)
PF01704
(UDPGP)
3 VAL A 280
GLU A 396
ILE A 328
None
0.44A 6f7lB-1jv1A:
undetectable
6f7lB-1jv1A:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1obb ALPHA-GLUCOSIDASE

(Thermotoga
maritima)
PF02056
(Glyco_hydro_4)
PF11975
(Glyco_hydro_4C)
3 VAL A 373
GLU A 391
ILE A 375
None
0.60A 6f7lB-1obbA:
1.8
6f7lB-1obbA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oi7 SUCCINYL-COA
SYNTHETASE ALPHA
CHAIN


(Thermus
thermophilus)
PF00549
(Ligase_CoA)
PF02629
(CoA_binding)
3 VAL A  47
GLU A  46
ILE A  15
None
0.64A 6f7lB-1oi7A:
4.0
6f7lB-1oi7A:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pp7 39 KDA INITIATOR
BINDING PROTEIN


(Trichomonas
vaginalis)
PF10416
(IBD)
3 VAL U  75
GLU U   7
ILE U  55
None
ZN  U 133 (-2.4A)
None
0.56A 6f7lB-1pp7U:
undetectable
6f7lB-1pp7U:
14.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1px8 BETA-XYLOSIDASE

(Thermoanaerobacterium
saccharolyticum)
PF01229
(Glyco_hydro_39)
3 VAL A 150
GLU A 149
ILE A 142
None
0.64A 6f7lB-1px8A:
undetectable
6f7lB-1px8A:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qgd PROTEIN
(TRANSKETOLASE)


(Escherichia
coli)
PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C)
3 VAL A 109
GLU A 110
ILE A  71
None
0.46A 6f7lB-1qgdA:
undetectable
6f7lB-1qgdA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r5j PUTATIVE
PHOSPHOTRANSACETYLAS
E


(Streptococcus
pyogenes)
PF01515
(PTA_PTB)
3 VAL A  55
GLU A  54
ILE A  71
None
0.50A 6f7lB-1r5jA:
4.4
6f7lB-1r5jA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r6b CLPA PROTEIN

(Escherichia
coli)
PF00004
(AAA)
PF02861
(Clp_N)
PF07724
(AAA_2)
PF10431
(ClpB_D2-small)
3 VAL X 682
GLU X 681
ILE X 666
None
0.48A 6f7lB-1r6bX:
undetectable
6f7lB-1r6bX:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r8g HYPOTHETICAL PROTEIN
YBDK


(Escherichia
coli)
PF04107
(GCS2)
3 VAL A 238
GLU A 237
ILE A 257
None
0.52A 6f7lB-1r8gA:
undetectable
6f7lB-1r8gA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ri3 MRNA CAPPING ENZYME

(Encephalitozoon
cuniculi)
PF03291
(Pox_MCEL)
3 VAL A 280
GLU A 279
ILE A  46
None
0.58A 6f7lB-1ri3A:
undetectable
6f7lB-1ri3A:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1se8 SINGLE-STRAND
BINDING PROTEIN


(Deinococcus
radiodurans)
PF00436
(SSB)
3 VAL A 228
GLU A 229
ILE A 201
None
0.63A 6f7lB-1se8A:
undetectable
6f7lB-1se8A:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tt4 PUTATIVE CYTOPLASMIC
PROTEIN


(Salmonella
enterica)
PF04107
(GCS2)
3 VAL A 238
GLU A 237
ILE A 257
None
MG  A 400 (-2.6A)
None
0.65A 6f7lB-1tt4A:
undetectable
6f7lB-1tt4A:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u0t INORGANIC
POLYPHOSPHATE/ATP-NA
D KINASE


(Mycobacterium
tuberculosis)
PF01513
(NAD_kinase)
3 VAL A 254
GLU A 164
ILE A 264
None
0.61A 6f7lB-1u0tA:
undetectable
6f7lB-1u0tA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v9s URACIL
PHOSPHORIBOSYLTRANSF
ERASE


(Thermus
thermophilus)
PF14681
(UPRTase)
3 VAL A  82
GLU A  85
ILE A 204
None
0.64A 6f7lB-1v9sA:
undetectable
6f7lB-1v9sA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vef ACETYLORNITHINE/ACET
YL-LYSINE
AMINOTRANSFERASE


(Thermus
thermophilus)
PF00202
(Aminotran_3)
3 VAL A  39
GLU A  46
ILE A  31
None
0.61A 6f7lB-1vefA:
undetectable
6f7lB-1vefA:
23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vio RIBOSOMAL SMALL
SUBUNIT
PSEUDOURIDINE
SYNTHASE A


(Haemophilus
influenzae)
PF00849
(PseudoU_synth_2)
PF01479
(S4)
3 VAL A 140
GLU A 141
ILE A 168
None
0.62A 6f7lB-1vioA:
undetectable
6f7lB-1vioA:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1we0 ALKYL HYDROPEROXIDE
REDUCTASE C


(Amphibacillus
xylanus)
PF00578
(AhpC-TSA)
PF10417
(1-cysPrx_C)
3 VAL A  24
GLU A  23
ILE A  97
None
0.63A 6f7lB-1we0A:
undetectable
6f7lB-1we0A:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wl4 ACETYL-COENZYME A
ACETYLTRANSFERASE 2


(Homo sapiens)
PF00108
(Thiolase_N)
PF02803
(Thiolase_C)
3 VAL A  55
GLU A  54
ILE A  79
None
0.65A 6f7lB-1wl4A:
undetectable
6f7lB-1wl4A:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x5g NEOGENIN

(Homo sapiens)
PF00041
(fn3)
3 VAL A 105
GLU A  83
ILE A  34
None
0.60A 6f7lB-1x5gA:
undetectable
6f7lB-1x5gA:
15.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y13 6-PYRUVOYL
TETRAHYDROPTERIN
SYNTHASE


(Plasmodium
falciparum)
PF01242
(PTPS)
3 VAL A  51
GLU A  15
ILE A 152
None
0.56A 6f7lB-1y13A:
undetectable
6f7lB-1y13A:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y17 ANTICOAGULANT
PROTEIN A


(Deinagkistrodon
acutus)
PF00059
(Lectin_C)
3 VAL A 105
GLU A 115
ILE A  68
None
0.36A 6f7lB-1y17A:
undetectable
6f7lB-1y17A:
12.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y9i LOW TEMPERATURE
REQUIREMENT C
PROTEIN


(Listeria
monocytogenes)
PF04608
(PgpA)
3 VAL A  23
GLU A  24
ILE A 127
None
0.59A 6f7lB-1y9iA:
undetectable
6f7lB-1y9iA:
17.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ys9 PROTEIN SPY1043

(Streptococcus
pyogenes)
PF13242
(Hydrolase_like)
PF13344
(Hydrolase_6)
3 VAL A  62
GLU A  63
ILE A  28
None
0.63A 6f7lB-1ys9A:
undetectable
6f7lB-1ys9A:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yy5 FMS1 PROTEIN

(Saccharomyces
cerevisiae)
PF01593
(Amino_oxidase)
3 VAL A 223
GLU A 222
ILE A  14
FAD  A 803 (-3.8A)
None
None
0.66A 6f7lB-1yy5A:
23.3
6f7lB-1yy5A:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yz1 TRANSLATIONALLY
CONTROLLED TUMOR
PROTEIN


(Homo sapiens)
PF00838
(TCTP)
3 VAL A  31
GLU A  30
ILE A  72
None
0.66A 6f7lB-1yz1A:
undetectable
6f7lB-1yz1A:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yzf LIPASE/ACYLHYDROLASE

(Enterococcus
faecalis)
PF13472
(Lipase_GDSL_2)
3 VAL A  71
GLU A  70
ILE A 102
None
0.60A 6f7lB-1yzfA:
2.3
6f7lB-1yzfA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z2m INTERFERON,
ALPHA-INDUCIBLE
PROTEIN (CLONE
IFI-15K)


(Homo sapiens)
PF00240
(ubiquitin)
3 VAL A  98
GLU A  97
ILE A  84
None
0.62A 6f7lB-1z2mA:
undetectable
6f7lB-1z2mA:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z3a TRNA-SPECIFIC
ADENOSINE DEAMINASE


(Escherichia
coli)
PF14437
(MafB19-deam)
3 VAL A 141
GLU A 142
ILE A 110
None
0.65A 6f7lB-1z3aA:
undetectable
6f7lB-1z3aA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zun SULFATE ADENYLATE
TRANSFERASE, SUBUNIT
1/ADENYLYLSULFATE
KINASE


(Pseudomonas
syringae group
genomosp. 3)
PF00009
(GTP_EFTU)
3 VAL B 287
GLU B 311
ILE B 276
None
0.64A 6f7lB-1zunB:
undetectable
6f7lB-1zunB:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zzm PUTATIVE
DEOXYRIBONUCLEASE
YJJV


(Escherichia
coli)
PF01026
(TatD_DNase)
3 VAL A 178
GLU A 205
ILE A 182
None
0.65A 6f7lB-1zzmA:
undetectable
6f7lB-1zzmA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b0t NADP ISOCITRATE
DEHYDROGENASE


(Corynebacterium
glutamicum)
PF03971
(IDH)
3 VAL A 457
GLU A 218
ILE A 462
None
0.65A 6f7lB-2b0tA:
undetectable
6f7lB-2b0tA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b39 C3

(Bos taurus)
PF00207
(A2M)
PF01759
(NTR)
PF01821
(ANATO)
PF01835
(A2M_N)
PF07677
(A2M_recep)
PF07678
(A2M_comp)
PF07703
(A2M_N_2)
PF10569
(Thiol-ester_cl)
3 VAL A 553
GLU A 462
ILE A 519
None
0.65A 6f7lB-2b39A:
undetectable
6f7lB-2b39A:
13.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bdq COPPER HOMEOSTASIS
PROTEIN CUTC


(Streptococcus
agalactiae)
PF03932
(CutC)
3 VAL A  25
GLU A   5
ILE A  55
None
0.59A 6f7lB-2bdqA:
undetectable
6f7lB-2bdqA:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dbb PUTATIVE HTH-TYPE
TRANSCRIPTIONAL
REGULATOR PH0061


(Pyrococcus
horikoshii)
PF13412
(HTH_24)
3 VAL A 137
GLU A 138
ILE A  74
None
0.66A 6f7lB-2dbbA:
undetectable
6f7lB-2dbbA:
15.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dgd 223AA LONG
HYPOTHETICAL
ARYLMALONATE
DECARBOXYLASE


(Sulfurisphaera
tokodaii)
no annotation 3 VAL A 126
GLU A 127
ILE A 136
None
0.59A 6f7lB-2dgdA:
undetectable
6f7lB-2dgdA:
16.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dha FLJ20171 PROTEIN

(Homo sapiens)
PF00076
(RRM_1)
3 VAL A 182
GLU A 181
ILE A 199
None
0.57A 6f7lB-2dhaA:
undetectable
6f7lB-2dhaA:
14.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dqi LYSOZYME BINDING IG
KAPPA CHAIN V23-J2
REGION


(Mus musculus)
PF07686
(V-set)
3 VAL L  78
GLU L  79
ILE L  75
None
0.65A 6f7lB-2dqiL:
undetectable
6f7lB-2dqiL:
14.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eap LYMPHOCYTE CYTOSOLIC
PROTEIN 2


(Homo sapiens)
PF07647
(SAM_2)
3 VAL A  19
GLU A  18
ILE A  79
None
0.60A 6f7lB-2eapA:
undetectable
6f7lB-2eapA:
11.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2emq HYPOTHETICAL
CONSERVED PROTEIN


(Geobacillus
kaustophilus)
PF00571
(CBS)
3 VAL A 133
GLU A 132
ILE A 109
None
0.60A 6f7lB-2emqA:
undetectable
6f7lB-2emqA:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f8q ALKALINE
THERMOSTABLE
ENDOXYLANASE


(Bacillus sp.
NG-27)
PF00331
(Glyco_hydro_10)
3 VAL A  25
GLU A  48
ILE A  71
None
0.63A 6f7lB-2f8qA:
undetectable
6f7lB-2f8qA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fvu REGULATORY PROTEIN
SIR3


(Saccharomyces
cerevisiae)
PF01426
(BAH)
3 VAL A 173
GLU A 131
ILE A 152
None
0.46A 6f7lB-2fvuA:
undetectable
6f7lB-2fvuA:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gou OXIDOREDUCTASE,
FMN-BINDING


(Shewanella
oneidensis)
PF00724
(Oxidored_FMN)
3 VAL A 232
GLU A 179
ILE A 264
None
0.58A 6f7lB-2gouA:
undetectable
6f7lB-2gouA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gpz TRANSTHYRETIN-LIKE
PROTEIN


(Salmonella
enterica)
PF00576
(Transthyretin)
3 VAL A  25
GLU A  24
ILE A  49
None
0.62A 6f7lB-2gpzA:
undetectable
6f7lB-2gpzA:
11.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gqd 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2


(Staphylococcus
aureus)
PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
3 VAL A   7
GLU A 257
ILE A 241
None
0.63A 6f7lB-2gqdA:
undetectable
6f7lB-2gqdA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2it4 CARBONIC ANHYDRASE 1

(Homo sapiens)
PF00194
(Carb_anhydrase)
3 VAL A 146
GLU A 117
ILE A 216
None
0.47A 6f7lB-2it4A:
undetectable
6f7lB-2it4A:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ji4 PHOSPHORIBOSYL
PYROPHOSPHATE
SYNTHETASE-ASSOCIATE
D PROTEIN 2


(Homo sapiens)
PF13793
(Pribosyltran_N)
PF14572
(Pribosyl_synth)
3 VAL A 318
GLU A 317
ILE A 310
None
0.64A 6f7lB-2ji4A:
undetectable
6f7lB-2ji4A:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jjq UNCHARACTERIZED RNA
METHYLTRANSFERASE
PYRAB10780


(Pyrococcus
abyssi)
PF05958
(tRNA_U5-meth_tr)
3 VAL A 269
GLU A 270
ILE A 274
None
0.64A 6f7lB-2jjqA:
undetectable
6f7lB-2jjqA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2k78 IRON-REGULATED
SURFACE DETERMINANT
PROTEIN C


(Staphylococcus
aureus)
PF05031
(NEAT)
3 VAL A  72
GLU A  99
ILE A  78
None
None
ZNH  A 151 ( 3.7A)
0.66A 6f7lB-2k78A:
undetectable
6f7lB-2k78A:
13.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2k8i PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE


(Escherichia
coli)
PF00254
(FKBP_C)
3 VAL A 112
GLU A 113
ILE A 109
None
0.65A 6f7lB-2k8iA:
undetectable
6f7lB-2k8iA:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ltj BETA-N-ACETYLHEXOSAM
INIDASE


(Streptococcus
pneumoniae)
PF07501
(G5)
3 VAL A 103
GLU A 104
ILE A  63
None
0.63A 6f7lB-2ltjA:
undetectable
6f7lB-2ltjA:
14.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ltl NIFU-LIKE PROTEIN,
MITOCHONDRIAL


(Saccharomyces
cerevisiae)
PF08712
(Nfu_N)
3 VAL A  74
GLU A  75
ILE A  86
None
0.49A 6f7lB-2ltlA:
undetectable
6f7lB-2ltlA:
14.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ma6 E3 UBIQUITIN-PROTEIN
LIGASE RNF123


(Homo sapiens)
PF13920
(zf-C3HC4_3)
3 VAL A  55
GLU A  56
ILE A  52
None
0.59A 6f7lB-2ma6A:
undetectable
6f7lB-2ma6A:
8.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mqj UBIQUITIN-LIKE
PROTEIN


(Candidatus
Caldiarchaeum
subterraneum)
PF00240
(ubiquitin)
3 VAL A  27
GLU A  26
ILE A  11
None
0.60A 6f7lB-2mqjA:
undetectable
6f7lB-2mqjA:
11.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2n8n TRANSLATION
INITIATION FACTOR
IF-1


(Staphylococcus
aureus)
PF01176
(eIF-1a)
3 VAL A  53
GLU A  10
ILE A  67
None
0.56A 6f7lB-2n8nA:
undetectable
6f7lB-2n8nA:
12.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o6p IRON-REGULATED
SURFACE DETERMINANT
PROTEIN C


(Staphylococcus
aureus)
PF05031
(NEAT)
3 VAL A  72
GLU A  99
ILE A  78
None
None
HEM  A 190 ( 4.7A)
0.66A 6f7lB-2o6pA:
undetectable
6f7lB-2o6pA:
14.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q04 ACETOIN UTILIZATION
PROTEIN


(Exiguobacterium
sibiricum)
PF00583
(Acetyltransf_1)
3 VAL A  18
GLU A  19
ILE A  72
None
0.66A 6f7lB-2q04A:
undetectable
6f7lB-2q04A:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qma DIAMINOBUTYRATE-PYRU
VATE TRANSAMINASE
AND
L-2,4-DIAMINOBUTYRAT
E DECARBOXYLASE


(Vibrio
parahaemolyticus)
PF00282
(Pyridoxal_deC)
3 VAL A 774
GLU A 775
ILE A 780
None
0.64A 6f7lB-2qmaA:
undetectable
6f7lB-2qmaA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rcv SUPEROXIDE DISMUTASE
[MN]


(Bacillus
subtilis)
PF00081
(Sod_Fe_N)
PF02777
(Sod_Fe_C)
3 VAL A 136
GLU A 142
ILE A 160
None
0.62A 6f7lB-2rcvA:
undetectable
6f7lB-2rcvA:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rd7 COMPLEMENT COMPONENT
C8 ALPHA CHAIN


(Homo sapiens)
PF01823
(MACPF)
3 VAL A 386
GLU A 387
ILE A 342
None
0.63A 6f7lB-2rd7A:
undetectable
6f7lB-2rd7A:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2re7 UNCHARACTERIZED
PROTEIN


(Psychrobacter
arcticus)
PF16242
(Pyrid_ox_like)
3 VAL A 127
GLU A 128
ILE A  83
SO4  A 135 (-4.6A)
None
None
0.65A 6f7lB-2re7A:
undetectable
6f7lB-2re7A:
11.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rmp MUCOROPEPSIN

(Rhizomucor
miehei)
PF00026
(Asp)
3 VAL A 182
GLU A 181
ILE A  22
None
NAG  A 600 ( 3.5A)
None
0.64A 6f7lB-2rmpA:
undetectable
6f7lB-2rmpA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rsn CHROMO
DOMAIN-CONTAINING
PROTEIN 1


(Schizosaccharomyces
pombe)
PF00385
(Chromo)
3 VAL A  24
GLU A  25
ILE A  42
None
0.61A 6f7lB-2rsnA:
undetectable
6f7lB-2rsnA:
12.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uwf ALKALINE ACTIVE
ENDOXYLANASE


(Bacillus
halodurans)
PF00331
(Glyco_hydro_10)
3 VAL A  35
GLU A  58
ILE A  81
None
0.55A 6f7lB-2uwfA:
undetectable
6f7lB-2uwfA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v3c SIGNAL RECOGNITION
54 KDA PROTEIN


(Methanocaldococcus
jannaschii)
PF00448
(SRP54)
PF02881
(SRP54_N)
PF02978
(SRP_SPB)
3 VAL C 172
GLU C 174
ILE C 209
None
0.66A 6f7lB-2v3cC:
undetectable
6f7lB-2v3cC:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vd9 ALANINE RACEMASE

(Bacillus
anthracis)
PF00842
(Ala_racemase_C)
PF01168
(Ala_racemase_N)
3 VAL A 309
GLU A 301
ILE A 322
MLY  A 307 ( 4.1A)
None
None
0.51A 6f7lB-2vd9A:
undetectable
6f7lB-2vd9A:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wii COMPLEMENT FACTOR H

(Homo sapiens)
PF00084
(Sushi)
3 VAL C 156
GLU C 171
ILE C 139
None
0.55A 6f7lB-2wiiC:
undetectable
6f7lB-2wiiC:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x4d PHOSPHOLYSINE
PHOSPHOHISTIDINE
INORGANIC
PYROPHOSPHATE
PHOSPHATASE


(Homo sapiens)
PF13242
(Hydrolase_like)
PF13344
(Hydrolase_6)
3 VAL A 248
GLU A 247
ILE A 216
None
0.66A 6f7lB-2x4dA:
undetectable
6f7lB-2x4dA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xig FERRIC UPTAKE
REGULATION PROTEIN


(Helicobacter
pylori)
PF01475
(FUR)
3 VAL A  32
GLU A  31
ILE A  67
None
0.64A 6f7lB-2xigA:
undetectable
6f7lB-2xigA:
14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xt6 2-OXOGLUTARATE
DECARBOXYLASE


(Mycolicibacterium
smegmatis)
PF00198
(2-oxoacid_dh)
PF00676
(E1_dh)
PF02779
(Transket_pyr)
PF16870
(OxoGdeHyase_C)
3 VAL A 597
GLU A 532
ILE A 522
None
0.50A 6f7lB-2xt6A:
undetectable
6f7lB-2xt6A:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y9x POLYPHENOL OXIDASE

(Agaricus
bisporus)
PF00264
(Tyrosinase)
3 VAL A 172
GLU A 171
ILE A 162
None
0.56A 6f7lB-2y9xA:
undetectable
6f7lB-2y9xA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yqh UDP-N-ACETYLGLUCOSAM
INE
PYROPHOSPHORYLASE


(Candida
albicans)
PF01704
(UDPGP)
3 VAL A 284
GLU A 410
ILE A 336
None
SO4  A1102 ( 4.5A)
None
0.46A 6f7lB-2yqhA:
1.0
6f7lB-2yqhA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yv2 SUCCINYL-COA
SYNTHETASE ALPHA
CHAIN


(Aeropyrum
pernix)
PF00549
(Ligase_CoA)
PF02629
(CoA_binding)
3 VAL A  56
GLU A  52
ILE A  21
None
0.57A 6f7lB-2yv2A:
4.4
6f7lB-2yv2A:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yyy GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE


(Methanocaldococcus
jannaschii)
PF01113
(DapB_N)
PF02800
(Gp_dh_C)
3 VAL A 232
GLU A 298
ILE A 156
None
0.64A 6f7lB-2yyyA:
5.3
6f7lB-2yyyA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yzi HYPOTHETICAL PROTEIN
PH0107


(Pyrococcus
horikoshii)
PF00571
(CBS)
3 VAL A  95
GLU A  94
ILE A  10
None
0.57A 6f7lB-2yziA:
undetectable
6f7lB-2yziA:
14.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zj8 PUTATIVE SKI2-TYPE
HELICASE


(Pyrococcus
furiosus)
PF00270
(DEAD)
PF00271
(Helicase_C)
PF14520
(HHH_5)
3 VAL A 312
GLU A 313
ILE A 321
None
0.66A 6f7lB-2zj8A:
undetectable
6f7lB-2zj8A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ztg ALANYL-TRNA
SYNTHETASE


(Archaeoglobus
fulgidus)
PF01411
(tRNA-synt_2c)
PF07973
(tRNA_SAD)
3 VAL A 568
GLU A 564
ILE A 530
None
0.46A 6f7lB-2ztgA:
undetectable
6f7lB-2ztgA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a8k AMINOMETHYLTRANSFERA
SE


(Escherichia
coli)
PF01571
(GCV_T)
PF08669
(GCV_T_C)
3 VAL A 329
GLU A 278
ILE A 333
None
0.64A 6f7lB-3a8kA:
undetectable
6f7lB-3a8kA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cgd PYRIDINE
NUCLEOTIDE-DISULFIDE
OXIDOREDUCTASE,
CLASS I


(Bacillus
anthracis)
PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2)
3 VAL A  80
GLU A  79
ILE A   6
FAD  A 446 ( 4.0A)
None
FAD  A 446 (-4.8A)
0.63A 6f7lB-3cgdA:
11.7
6f7lB-3cgdA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cnv PUTATIVE GNTR-FAMILY
TRANSCRIPTIONAL
REGULATOR


(Bordetella
bronchiseptica)
PF07702
(UTRA)
3 VAL A 242
GLU A 241
ILE A 132
None
0.62A 6f7lB-3cnvA:
undetectable
6f7lB-3cnvA:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d3f YVGN PROTEIN

(Bacillus
subtilis)
PF00248
(Aldo_ket_red)
3 VAL A  27
GLU A  28
ILE A 234
None
None
NDP  A   1 (-4.1A)
0.40A 6f7lB-3d3fA:
undetectable
6f7lB-3d3fA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3da2 CARBONIC ANHYDRASE
13


(Homo sapiens)
PF00194
(Carb_anhydrase)
3 VAL A 147
GLU A 118
ILE A 217
None
0.60A 6f7lB-3da2A:
undetectable
6f7lB-3da2A:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ddj CBS
DOMAIN-CONTAINING
PROTEIN


(Sulfolobus
solfataricus)
PF00571
(CBS)
3 VAL A 121
GLU A 125
ILE A   3
None
0.65A 6f7lB-3ddjA:
undetectable
6f7lB-3ddjA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3deo SIGNAL RECOGNITION
PARTICLE 43 KDA
PROTEIN


(Arabidopsis
thaliana)
PF12796
(Ank_2)
3 VAL A 115
GLU A 101
ILE A 120
None
0.58A 6f7lB-3deoA:
undetectable
6f7lB-3deoA:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dlv SIGNAL RECOGNITION
PARTICLE 19 KDA
PROTEIN


(Pyrococcus
furiosus)
no annotation 3 VAL B  51
GLU B  52
ILE B  73
None
0.66A 6f7lB-3dlvB:
undetectable
6f7lB-3dlvB:
14.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3du4 ADENOSYLMETHIONINE-8
-AMINO-7-OXONONANOAT
E AMINOTRANSFERASE


(Bacillus
subtilis)
PF00202
(Aminotran_3)
3 VAL A  38
GLU A  45
ILE A  30
None
0.57A 6f7lB-3du4A:
undetectable
6f7lB-3du4A:
22.49