SIMILAR PATTERNS OF AMINO ACIDS FOR 6F7L_B_ACTB503
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1b7g | PROTEIN(GLYCERALDEHYDE3-PHOSPHATEDEHYDROGENASE) (Sulfolobussolfataricus) |
PF01113(DapB_N)PF02800(Gp_dh_C) | 3 | VAL O 157GLU O 158ILE O 225 | None | 0.63A | 6f7lB-1b7gO:4.3 | 6f7lB-1b7gO:20.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1bbu | PROTEIN (LYSYL-TRNASYNTHETASE) (Escherichiacoli) |
PF00152(tRNA-synt_2)PF01336(tRNA_anti-codon) | 3 | VAL A 361GLU A 362ILE A 370 | None | 0.49A | 6f7lB-1bbuA:undetectable | 6f7lB-1bbuA:23.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1bft | NUCLEAR FACTORNF-KAPPA-B P65 (Mus musculus) |
PF16179(RHD_dimer) | 3 | VAL A 226GLU A 225ILE A 250 | None | 0.65A | 6f7lB-1bftA:undetectable | 6f7lB-1bftA:13.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1bja | TRANSCRIPTIONREGULATORY PROTEINMOTA (Escherichiavirus T4) |
PF09114(MotA_activ) | 3 | VAL A 62GLU A 63ILE A 26 | None | 0.63A | 6f7lB-1bjaA:undetectable | 6f7lB-1bjaA:11.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1dll | TETANUS TOXIN (Clostridiumtetani) |
PF07951(Toxin_R_bind_C)PF07953(Toxin_R_bind_N) | 3 | VAL A 933GLU A 932ILE A 923 | None | 0.59A | 6f7lB-1dllA:undetectable | 6f7lB-1dllA:20.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1e1t | LYSYL-TRNASYNTHETASE, HEATINDUCIBLE (Escherichiacoli) |
PF00152(tRNA-synt_2)PF01336(tRNA_anti-codon) | 3 | VAL A 361GLU A 362ILE A 370 | None | 0.52A | 6f7lB-1e1tA:undetectable | 6f7lB-1e1tA:22.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ex0 | COAGULATION FACTORXIII A CHAIN (Homo sapiens) |
PF00868(Transglut_N)PF00927(Transglut_C)PF01841(Transglut_core) | 3 | VAL A 452GLU A 453ILE A 440 | None | 0.65A | 6f7lB-1ex0A:undetectable | 6f7lB-1ex0A:22.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1hh2 | N UTILIZATIONSUBSTANCE PROTEIN A (Thermotogamaritima) |
PF00575(S1)PF08529(NusA_N)PF13184(KH_5) | 3 | VAL P 23GLU P 22ILE P 18 | None | 0.64A | 6f7lB-1hh2P:undetectable | 6f7lB-1hh2P:20.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1i7q | TRPG (Serratiamarcescens) |
PF00117(GATase) | 3 | VAL B 39GLU B 38ILE B 35 | None | 0.65A | 6f7lB-1i7qB:undetectable | 6f7lB-1i7qB:17.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1i9a | ISOPENTENYL-DIPHOSPHATE DELTA-ISOMERASE (Escherichiacoli) |
PF00293(NUDIX) | 3 | VAL A 136GLU A 135ILE A 131 | None | 0.66A | 6f7lB-1i9aA:undetectable | 6f7lB-1i9aA:16.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1if1 | PROTEIN (INTERFERONREGULATORY FACTOR 1) (Mus musculus) |
PF00605(IRF) | 3 | VAL A 106GLU A 93ILE A 33 | None | 0.60A | 6f7lB-1if1A:undetectable | 6f7lB-1if1A:11.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ii8 | RAD50 ABC-ATPASERAD50 ABC-ATPASE (Pyrococcusfuriosus;Pyrococcusfuriosus) |
PF13476(AAA_23)PF13304(AAA_21) | 3 | VAL A 19GLU A 20ILE B 867 | None | 0.64A | 6f7lB-1ii8A:undetectable | 6f7lB-1ii8A:20.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ik6 | PYRUVATEDEHYDROGENASE (Pyrobaculumaerophilum) |
PF02779(Transket_pyr)PF02780(Transketolase_C) | 3 | VAL A 274GLU A 273ILE A 260 | None | 0.66A | 6f7lB-1ik6A:undetectable | 6f7lB-1ik6A:23.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1j2b | ARCHAEOSINETRNA-GUANINETRANSGLYCOSYLASE (Pyrococcushorikoshii) |
PF01472(PUA)PF01702(TGT)PF14809(TGT_C1)PF14810(TGT_C2) | 3 | VAL A 26GLU A 25ILE A 91 | None | 0.56A | 6f7lB-1j2bA:undetectable | 6f7lB-1j2bA:21.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ji5 | DLP-1 (Bacillusanthracis) |
PF00210(Ferritin) | 3 | VAL A 8GLU A 7ILE A 113 | None | 0.59A | 6f7lB-1ji5A:undetectable | 6f7lB-1ji5A:15.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1jv1 | GLCNAC1PURIDYLTRANSFERASEISOFORM 1: AGX1 (Homo sapiens) |
PF01704(UDPGP) | 3 | VAL A 280GLU A 396ILE A 328 | None | 0.44A | 6f7lB-1jv1A:undetectable | 6f7lB-1jv1A:21.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1obb | ALPHA-GLUCOSIDASE (Thermotogamaritima) |
PF02056(Glyco_hydro_4)PF11975(Glyco_hydro_4C) | 3 | VAL A 373GLU A 391ILE A 375 | None | 0.60A | 6f7lB-1obbA:1.8 | 6f7lB-1obbA:21.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1oi7 | SUCCINYL-COASYNTHETASE ALPHACHAIN (Thermusthermophilus) |
PF00549(Ligase_CoA)PF02629(CoA_binding) | 3 | VAL A 47GLU A 46ILE A 15 | None | 0.64A | 6f7lB-1oi7A:4.0 | 6f7lB-1oi7A:20.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1pp7 | 39 KDA INITIATORBINDING PROTEIN (Trichomonasvaginalis) |
PF10416(IBD) | 3 | VAL U 75GLU U 7ILE U 55 | None ZN U 133 (-2.4A)None | 0.56A | 6f7lB-1pp7U:undetectable | 6f7lB-1pp7U:14.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1px8 | BETA-XYLOSIDASE (Thermoanaerobacteriumsaccharolyticum) |
PF01229(Glyco_hydro_39) | 3 | VAL A 150GLU A 149ILE A 142 | None | 0.64A | 6f7lB-1px8A:undetectable | 6f7lB-1px8A:21.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1qgd | PROTEIN(TRANSKETOLASE) (Escherichiacoli) |
PF00456(Transketolase_N)PF02779(Transket_pyr)PF02780(Transketolase_C) | 3 | VAL A 109GLU A 110ILE A 71 | None | 0.46A | 6f7lB-1qgdA:undetectable | 6f7lB-1qgdA:21.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1r5j | PUTATIVEPHOSPHOTRANSACETYLASE (Streptococcuspyogenes) |
PF01515(PTA_PTB) | 3 | VAL A 55GLU A 54ILE A 71 | None | 0.50A | 6f7lB-1r5jA:4.4 | 6f7lB-1r5jA:21.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1r6b | CLPA PROTEIN (Escherichiacoli) |
PF00004(AAA)PF02861(Clp_N)PF07724(AAA_2)PF10431(ClpB_D2-small) | 3 | VAL X 682GLU X 681ILE X 666 | None | 0.48A | 6f7lB-1r6bX:undetectable | 6f7lB-1r6bX:21.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1r8g | HYPOTHETICAL PROTEINYBDK (Escherichiacoli) |
PF04107(GCS2) | 3 | VAL A 238GLU A 237ILE A 257 | None | 0.52A | 6f7lB-1r8gA:undetectable | 6f7lB-1r8gA:21.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ri3 | MRNA CAPPING ENZYME (Encephalitozooncuniculi) |
PF03291(Pox_MCEL) | 3 | VAL A 280GLU A 279ILE A 46 | None | 0.58A | 6f7lB-1ri3A:undetectable | 6f7lB-1ri3A:22.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1se8 | SINGLE-STRANDBINDING PROTEIN (Deinococcusradiodurans) |
PF00436(SSB) | 3 | VAL A 228GLU A 229ILE A 201 | None | 0.63A | 6f7lB-1se8A:undetectable | 6f7lB-1se8A:21.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1tt4 | PUTATIVE CYTOPLASMICPROTEIN (Salmonellaenterica) |
PF04107(GCS2) | 3 | VAL A 238GLU A 237ILE A 257 | None MG A 400 (-2.6A)None | 0.65A | 6f7lB-1tt4A:undetectable | 6f7lB-1tt4A:21.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1u0t | INORGANICPOLYPHOSPHATE/ATP-NAD KINASE (Mycobacteriumtuberculosis) |
PF01513(NAD_kinase) | 3 | VAL A 254GLU A 164ILE A 264 | None | 0.61A | 6f7lB-1u0tA:undetectable | 6f7lB-1u0tA:22.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1v9s | URACILPHOSPHORIBOSYLTRANSFERASE (Thermusthermophilus) |
PF14681(UPRTase) | 3 | VAL A 82GLU A 85ILE A 204 | None | 0.64A | 6f7lB-1v9sA:undetectable | 6f7lB-1v9sA:18.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1vef | ACETYLORNITHINE/ACETYL-LYSINEAMINOTRANSFERASE (Thermusthermophilus) |
PF00202(Aminotran_3) | 3 | VAL A 39GLU A 46ILE A 31 | None | 0.61A | 6f7lB-1vefA:undetectable | 6f7lB-1vefA:23.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1vio | RIBOSOMAL SMALLSUBUNITPSEUDOURIDINESYNTHASE A (Haemophilusinfluenzae) |
PF00849(PseudoU_synth_2)PF01479(S4) | 3 | VAL A 140GLU A 141ILE A 168 | None | 0.62A | 6f7lB-1vioA:undetectable | 6f7lB-1vioA:19.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1we0 | ALKYL HYDROPEROXIDEREDUCTASE C (Amphibacillusxylanus) |
PF00578(AhpC-TSA)PF10417(1-cysPrx_C) | 3 | VAL A 24GLU A 23ILE A 97 | None | 0.63A | 6f7lB-1we0A:undetectable | 6f7lB-1we0A:17.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1wl4 | ACETYL-COENZYME AACETYLTRANSFERASE 2 (Homo sapiens) |
PF00108(Thiolase_N)PF02803(Thiolase_C) | 3 | VAL A 55GLU A 54ILE A 79 | None | 0.65A | 6f7lB-1wl4A:undetectable | 6f7lB-1wl4A:21.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1x5g | NEOGENIN (Homo sapiens) |
PF00041(fn3) | 3 | VAL A 105GLU A 83ILE A 34 | None | 0.60A | 6f7lB-1x5gA:undetectable | 6f7lB-1x5gA:15.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1y13 | 6-PYRUVOYLTETRAHYDROPTERINSYNTHASE (Plasmodiumfalciparum) |
PF01242(PTPS) | 3 | VAL A 51GLU A 15ILE A 152 | None | 0.56A | 6f7lB-1y13A:undetectable | 6f7lB-1y13A:16.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1y17 | ANTICOAGULANTPROTEIN A (Deinagkistrodonacutus) |
PF00059(Lectin_C) | 3 | VAL A 105GLU A 115ILE A 68 | None | 0.36A | 6f7lB-1y17A:undetectable | 6f7lB-1y17A:12.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1y9i | LOW TEMPERATUREREQUIREMENT CPROTEIN (Listeriamonocytogenes) |
PF04608(PgpA) | 3 | VAL A 23GLU A 24ILE A 127 | None | 0.59A | 6f7lB-1y9iA:undetectable | 6f7lB-1y9iA:17.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ys9 | PROTEIN SPY1043 (Streptococcuspyogenes) |
PF13242(Hydrolase_like)PF13344(Hydrolase_6) | 3 | VAL A 62GLU A 63ILE A 28 | None | 0.63A | 6f7lB-1ys9A:undetectable | 6f7lB-1ys9A:19.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1yy5 | FMS1 PROTEIN (Saccharomycescerevisiae) |
PF01593(Amino_oxidase) | 3 | VAL A 223GLU A 222ILE A 14 | FAD A 803 (-3.8A)NoneNone | 0.66A | 6f7lB-1yy5A:23.3 | 6f7lB-1yy5A:22.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1yz1 | TRANSLATIONALLYCONTROLLED TUMORPROTEIN (Homo sapiens) |
PF00838(TCTP) | 3 | VAL A 31GLU A 30ILE A 72 | None | 0.66A | 6f7lB-1yz1A:undetectable | 6f7lB-1yz1A:16.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1yzf | LIPASE/ACYLHYDROLASE (Enterococcusfaecalis) |
PF13472(Lipase_GDSL_2) | 3 | VAL A 71GLU A 70ILE A 102 | None | 0.60A | 6f7lB-1yzfA:2.3 | 6f7lB-1yzfA:19.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1z2m | INTERFERON,ALPHA-INDUCIBLEPROTEIN (CLONEIFI-15K) (Homo sapiens) |
PF00240(ubiquitin) | 3 | VAL A 98GLU A 97ILE A 84 | None | 0.62A | 6f7lB-1z2mA:undetectable | 6f7lB-1z2mA:16.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1z3a | TRNA-SPECIFICADENOSINE DEAMINASE (Escherichiacoli) |
PF14437(MafB19-deam) | 3 | VAL A 141GLU A 142ILE A 110 | None | 0.65A | 6f7lB-1z3aA:undetectable | 6f7lB-1z3aA:18.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1zun | SULFATE ADENYLATETRANSFERASE, SUBUNIT1/ADENYLYLSULFATEKINASE (Pseudomonassyringae groupgenomosp. 3) |
PF00009(GTP_EFTU) | 3 | VAL B 287GLU B 311ILE B 276 | None | 0.64A | 6f7lB-1zunB:undetectable | 6f7lB-1zunB:22.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1zzm | PUTATIVEDEOXYRIBONUCLEASEYJJV (Escherichiacoli) |
PF01026(TatD_DNase) | 3 | VAL A 178GLU A 205ILE A 182 | None | 0.65A | 6f7lB-1zzmA:undetectable | 6f7lB-1zzmA:20.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2b0t | NADP ISOCITRATEDEHYDROGENASE (Corynebacteriumglutamicum) |
PF03971(IDH) | 3 | VAL A 457GLU A 218ILE A 462 | None | 0.65A | 6f7lB-2b0tA:undetectable | 6f7lB-2b0tA:20.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2b39 | C3 (Bos taurus) |
PF00207(A2M)PF01759(NTR)PF01821(ANATO)PF01835(A2M_N)PF07677(A2M_recep)PF07678(A2M_comp)PF07703(A2M_N_2)PF10569(Thiol-ester_cl) | 3 | VAL A 553GLU A 462ILE A 519 | None | 0.65A | 6f7lB-2b39A:undetectable | 6f7lB-2b39A:13.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2bdq | COPPER HOMEOSTASISPROTEIN CUTC (Streptococcusagalactiae) |
PF03932(CutC) | 3 | VAL A 25GLU A 5ILE A 55 | None | 0.59A | 6f7lB-2bdqA:undetectable | 6f7lB-2bdqA:18.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2dbb | PUTATIVE HTH-TYPETRANSCRIPTIONALREGULATOR PH0061 (Pyrococcushorikoshii) |
PF13412(HTH_24) | 3 | VAL A 137GLU A 138ILE A 74 | None | 0.66A | 6f7lB-2dbbA:undetectable | 6f7lB-2dbbA:15.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2dgd | 223AA LONGHYPOTHETICALARYLMALONATEDECARBOXYLASE (Sulfurisphaeratokodaii) |
no annotation | 3 | VAL A 126GLU A 127ILE A 136 | None | 0.59A | 6f7lB-2dgdA:undetectable | 6f7lB-2dgdA:16.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2dha | FLJ20171 PROTEIN (Homo sapiens) |
PF00076(RRM_1) | 3 | VAL A 182GLU A 181ILE A 199 | None | 0.57A | 6f7lB-2dhaA:undetectable | 6f7lB-2dhaA:14.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2dqi | LYSOZYME BINDING IGKAPPA CHAIN V23-J2REGION (Mus musculus) |
PF07686(V-set) | 3 | VAL L 78GLU L 79ILE L 75 | None | 0.65A | 6f7lB-2dqiL:undetectable | 6f7lB-2dqiL:14.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2eap | LYMPHOCYTE CYTOSOLICPROTEIN 2 (Homo sapiens) |
PF07647(SAM_2) | 3 | VAL A 19GLU A 18ILE A 79 | None | 0.60A | 6f7lB-2eapA:undetectable | 6f7lB-2eapA:11.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2emq | HYPOTHETICALCONSERVED PROTEIN (Geobacilluskaustophilus) |
PF00571(CBS) | 3 | VAL A 133GLU A 132ILE A 109 | None | 0.60A | 6f7lB-2emqA:undetectable | 6f7lB-2emqA:18.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2f8q | ALKALINETHERMOSTABLEENDOXYLANASE (Bacillus sp.NG-27) |
PF00331(Glyco_hydro_10) | 3 | VAL A 25GLU A 48ILE A 71 | None | 0.63A | 6f7lB-2f8qA:undetectable | 6f7lB-2f8qA:22.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2fvu | REGULATORY PROTEINSIR3 (Saccharomycescerevisiae) |
PF01426(BAH) | 3 | VAL A 173GLU A 131ILE A 152 | None | 0.46A | 6f7lB-2fvuA:undetectable | 6f7lB-2fvuA:18.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2gou | OXIDOREDUCTASE,FMN-BINDING (Shewanellaoneidensis) |
PF00724(Oxidored_FMN) | 3 | VAL A 232GLU A 179ILE A 264 | None | 0.58A | 6f7lB-2gouA:undetectable | 6f7lB-2gouA:22.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2gpz | TRANSTHYRETIN-LIKEPROTEIN (Salmonellaenterica) |
PF00576(Transthyretin) | 3 | VAL A 25GLU A 24ILE A 49 | None | 0.62A | 6f7lB-2gpzA:undetectable | 6f7lB-2gpzA:11.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2gqd | 3-OXOACYL-[ACYL-CARRIER-PROTEIN]SYNTHASE 2 (Staphylococcusaureus) |
PF00109(ketoacyl-synt)PF02801(Ketoacyl-synt_C) | 3 | VAL A 7GLU A 257ILE A 241 | None | 0.63A | 6f7lB-2gqdA:undetectable | 6f7lB-2gqdA:22.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2it4 | CARBONIC ANHYDRASE 1 (Homo sapiens) |
PF00194(Carb_anhydrase) | 3 | VAL A 146GLU A 117ILE A 216 | None | 0.47A | 6f7lB-2it4A:undetectable | 6f7lB-2it4A:20.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ji4 | PHOSPHORIBOSYLPYROPHOSPHATESYNTHETASE-ASSOCIATED PROTEIN 2 (Homo sapiens) |
PF13793(Pribosyltran_N)PF14572(Pribosyl_synth) | 3 | VAL A 318GLU A 317ILE A 310 | None | 0.64A | 6f7lB-2ji4A:undetectable | 6f7lB-2ji4A:22.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2jjq | UNCHARACTERIZED RNAMETHYLTRANSFERASEPYRAB10780 (Pyrococcusabyssi) |
PF05958(tRNA_U5-meth_tr) | 3 | VAL A 269GLU A 270ILE A 274 | None | 0.64A | 6f7lB-2jjqA:undetectable | 6f7lB-2jjqA:20.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2k78 | IRON-REGULATEDSURFACE DETERMINANTPROTEIN C (Staphylococcusaureus) |
PF05031(NEAT) | 3 | VAL A 72GLU A 99ILE A 78 | NoneNoneZNH A 151 ( 3.7A) | 0.66A | 6f7lB-2k78A:undetectable | 6f7lB-2k78A:13.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2k8i | PEPTIDYL-PROLYLCIS-TRANS ISOMERASE (Escherichiacoli) |
PF00254(FKBP_C) | 3 | VAL A 112GLU A 113ILE A 109 | None | 0.65A | 6f7lB-2k8iA:undetectable | 6f7lB-2k8iA:18.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ltj | BETA-N-ACETYLHEXOSAMINIDASE (Streptococcuspneumoniae) |
PF07501(G5) | 3 | VAL A 103GLU A 104ILE A 63 | None | 0.63A | 6f7lB-2ltjA:undetectable | 6f7lB-2ltjA:14.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ltl | NIFU-LIKE PROTEIN,MITOCHONDRIAL (Saccharomycescerevisiae) |
PF08712(Nfu_N) | 3 | VAL A 74GLU A 75ILE A 86 | None | 0.49A | 6f7lB-2ltlA:undetectable | 6f7lB-2ltlA:14.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ma6 | E3 UBIQUITIN-PROTEINLIGASE RNF123 (Homo sapiens) |
PF13920(zf-C3HC4_3) | 3 | VAL A 55GLU A 56ILE A 52 | None | 0.59A | 6f7lB-2ma6A:undetectable | 6f7lB-2ma6A:8.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2mqj | UBIQUITIN-LIKEPROTEIN (CandidatusCaldiarchaeumsubterraneum) |
PF00240(ubiquitin) | 3 | VAL A 27GLU A 26ILE A 11 | None | 0.60A | 6f7lB-2mqjA:undetectable | 6f7lB-2mqjA:11.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2n8n | TRANSLATIONINITIATION FACTORIF-1 (Staphylococcusaureus) |
PF01176(eIF-1a) | 3 | VAL A 53GLU A 10ILE A 67 | None | 0.56A | 6f7lB-2n8nA:undetectable | 6f7lB-2n8nA:12.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2o6p | IRON-REGULATEDSURFACE DETERMINANTPROTEIN C (Staphylococcusaureus) |
PF05031(NEAT) | 3 | VAL A 72GLU A 99ILE A 78 | NoneNoneHEM A 190 ( 4.7A) | 0.66A | 6f7lB-2o6pA:undetectable | 6f7lB-2o6pA:14.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2q04 | ACETOIN UTILIZATIONPROTEIN (Exiguobacteriumsibiricum) |
PF00583(Acetyltransf_1) | 3 | VAL A 18GLU A 19ILE A 72 | None | 0.66A | 6f7lB-2q04A:undetectable | 6f7lB-2q04A:18.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qma | DIAMINOBUTYRATE-PYRUVATE TRANSAMINASEANDL-2,4-DIAMINOBUTYRATE DECARBOXYLASE (Vibrioparahaemolyticus) |
PF00282(Pyridoxal_deC) | 3 | VAL A 774GLU A 775ILE A 780 | None | 0.64A | 6f7lB-2qmaA:undetectable | 6f7lB-2qmaA:20.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2rcv | SUPEROXIDE DISMUTASE[MN] (Bacillussubtilis) |
PF00081(Sod_Fe_N)PF02777(Sod_Fe_C) | 3 | VAL A 136GLU A 142ILE A 160 | None | 0.62A | 6f7lB-2rcvA:undetectable | 6f7lB-2rcvA:16.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2rd7 | COMPLEMENT COMPONENTC8 ALPHA CHAIN (Homo sapiens) |
PF01823(MACPF) | 3 | VAL A 386GLU A 387ILE A 342 | None | 0.63A | 6f7lB-2rd7A:undetectable | 6f7lB-2rd7A:21.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2re7 | UNCHARACTERIZEDPROTEIN (Psychrobacterarcticus) |
PF16242(Pyrid_ox_like) | 3 | VAL A 127GLU A 128ILE A 83 | SO4 A 135 (-4.6A)NoneNone | 0.65A | 6f7lB-2re7A:undetectable | 6f7lB-2re7A:11.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2rmp | MUCOROPEPSIN (Rhizomucormiehei) |
PF00026(Asp) | 3 | VAL A 182GLU A 181ILE A 22 | NoneNAG A 600 ( 3.5A)None | 0.64A | 6f7lB-2rmpA:undetectable | 6f7lB-2rmpA:20.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2rsn | CHROMODOMAIN-CONTAININGPROTEIN 1 (Schizosaccharomycespombe) |
PF00385(Chromo) | 3 | VAL A 24GLU A 25ILE A 42 | None | 0.61A | 6f7lB-2rsnA:undetectable | 6f7lB-2rsnA:12.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2uwf | ALKALINE ACTIVEENDOXYLANASE (Bacillushalodurans) |
PF00331(Glyco_hydro_10) | 3 | VAL A 35GLU A 58ILE A 81 | None | 0.55A | 6f7lB-2uwfA:undetectable | 6f7lB-2uwfA:21.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2v3c | SIGNAL RECOGNITION54 KDA PROTEIN (Methanocaldococcusjannaschii) |
PF00448(SRP54)PF02881(SRP54_N)PF02978(SRP_SPB) | 3 | VAL C 172GLU C 174ILE C 209 | None | 0.66A | 6f7lB-2v3cC:undetectable | 6f7lB-2v3cC:19.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2vd9 | ALANINE RACEMASE (Bacillusanthracis) |
PF00842(Ala_racemase_C)PF01168(Ala_racemase_N) | 3 | VAL A 309GLU A 301ILE A 322 | MLY A 307 ( 4.1A)NoneNone | 0.51A | 6f7lB-2vd9A:undetectable | 6f7lB-2vd9A:21.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2wii | COMPLEMENT FACTOR H (Homo sapiens) |
PF00084(Sushi) | 3 | VAL C 156GLU C 171ILE C 139 | None | 0.55A | 6f7lB-2wiiC:undetectable | 6f7lB-2wiiC:17.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2x4d | PHOSPHOLYSINEPHOSPHOHISTIDINEINORGANICPYROPHOSPHATEPHOSPHATASE (Homo sapiens) |
PF13242(Hydrolase_like)PF13344(Hydrolase_6) | 3 | VAL A 248GLU A 247ILE A 216 | None | 0.66A | 6f7lB-2x4dA:undetectable | 6f7lB-2x4dA:21.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2xig | FERRIC UPTAKEREGULATION PROTEIN (Helicobacterpylori) |
PF01475(FUR) | 3 | VAL A 32GLU A 31ILE A 67 | None | 0.64A | 6f7lB-2xigA:undetectable | 6f7lB-2xigA:14.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2xt6 | 2-OXOGLUTARATEDECARBOXYLASE (Mycolicibacteriumsmegmatis) |
PF00198(2-oxoacid_dh)PF00676(E1_dh)PF02779(Transket_pyr)PF16870(OxoGdeHyase_C) | 3 | VAL A 597GLU A 532ILE A 522 | None | 0.50A | 6f7lB-2xt6A:undetectable | 6f7lB-2xt6A:17.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2y9x | POLYPHENOL OXIDASE (Agaricusbisporus) |
PF00264(Tyrosinase) | 3 | VAL A 172GLU A 171ILE A 162 | None | 0.56A | 6f7lB-2y9xA:undetectable | 6f7lB-2y9xA:21.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2yqh | UDP-N-ACETYLGLUCOSAMINEPYROPHOSPHORYLASE (Candidaalbicans) |
PF01704(UDPGP) | 3 | VAL A 284GLU A 410ILE A 336 | NoneSO4 A1102 ( 4.5A)None | 0.46A | 6f7lB-2yqhA:1.0 | 6f7lB-2yqhA:21.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2yv2 | SUCCINYL-COASYNTHETASE ALPHACHAIN (Aeropyrumpernix) |
PF00549(Ligase_CoA)PF02629(CoA_binding) | 3 | VAL A 56GLU A 52ILE A 21 | None | 0.57A | 6f7lB-2yv2A:4.4 | 6f7lB-2yv2A:21.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2yyy | GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE (Methanocaldococcusjannaschii) |
PF01113(DapB_N)PF02800(Gp_dh_C) | 3 | VAL A 232GLU A 298ILE A 156 | None | 0.64A | 6f7lB-2yyyA:5.3 | 6f7lB-2yyyA:22.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2yzi | HYPOTHETICAL PROTEINPH0107 (Pyrococcushorikoshii) |
PF00571(CBS) | 3 | VAL A 95GLU A 94ILE A 10 | None | 0.57A | 6f7lB-2yziA:undetectable | 6f7lB-2yziA:14.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2zj8 | PUTATIVE SKI2-TYPEHELICASE (Pyrococcusfuriosus) |
PF00270(DEAD)PF00271(Helicase_C)PF14520(HHH_5) | 3 | VAL A 312GLU A 313ILE A 321 | None | 0.66A | 6f7lB-2zj8A:undetectable | 6f7lB-2zj8A:21.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ztg | ALANYL-TRNASYNTHETASE (Archaeoglobusfulgidus) |
PF01411(tRNA-synt_2c)PF07973(tRNA_SAD) | 3 | VAL A 568GLU A 564ILE A 530 | None | 0.46A | 6f7lB-2ztgA:undetectable | 6f7lB-2ztgA:20.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3a8k | AMINOMETHYLTRANSFERASE (Escherichiacoli) |
PF01571(GCV_T)PF08669(GCV_T_C) | 3 | VAL A 329GLU A 278ILE A 333 | None | 0.64A | 6f7lB-3a8kA:undetectable | 6f7lB-3a8kA:22.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3cgd | PYRIDINENUCLEOTIDE-DISULFIDEOXIDOREDUCTASE,CLASS I (Bacillusanthracis) |
PF02852(Pyr_redox_dim)PF07992(Pyr_redox_2) | 3 | VAL A 80GLU A 79ILE A 6 | FAD A 446 ( 4.0A)NoneFAD A 446 (-4.8A) | 0.63A | 6f7lB-3cgdA:11.7 | 6f7lB-3cgdA:22.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3cnv | PUTATIVE GNTR-FAMILYTRANSCRIPTIONALREGULATOR (Bordetellabronchiseptica) |
PF07702(UTRA) | 3 | VAL A 242GLU A 241ILE A 132 | None | 0.62A | 6f7lB-3cnvA:undetectable | 6f7lB-3cnvA:18.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3d3f | YVGN PROTEIN (Bacillussubtilis) |
PF00248(Aldo_ket_red) | 3 | VAL A 27GLU A 28ILE A 234 | NoneNoneNDP A 1 (-4.1A) | 0.40A | 6f7lB-3d3fA:undetectable | 6f7lB-3d3fA:21.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3da2 | CARBONIC ANHYDRASE13 (Homo sapiens) |
PF00194(Carb_anhydrase) | 3 | VAL A 147GLU A 118ILE A 217 | None | 0.60A | 6f7lB-3da2A:undetectable | 6f7lB-3da2A:21.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ddj | CBSDOMAIN-CONTAININGPROTEIN (Sulfolobussolfataricus) |
PF00571(CBS) | 3 | VAL A 121GLU A 125ILE A 3 | None | 0.65A | 6f7lB-3ddjA:undetectable | 6f7lB-3ddjA:20.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3deo | SIGNAL RECOGNITIONPARTICLE 43 KDAPROTEIN (Arabidopsisthaliana) |
PF12796(Ank_2) | 3 | VAL A 115GLU A 101ILE A 120 | None | 0.58A | 6f7lB-3deoA:undetectable | 6f7lB-3deoA:18.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3dlv | SIGNAL RECOGNITIONPARTICLE 19 KDAPROTEIN (Pyrococcusfuriosus) |
no annotation | 3 | VAL B 51GLU B 52ILE B 73 | None | 0.66A | 6f7lB-3dlvB:undetectable | 6f7lB-3dlvB:14.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3du4 | ADENOSYLMETHIONINE-8-AMINO-7-OXONONANOATE AMINOTRANSFERASE (Bacillussubtilis) |
PF00202(Aminotran_3) | 3 | VAL A 38GLU A 45ILE A 30 | None | 0.57A | 6f7lB-3du4A:undetectable | 6f7lB-3du4A:22.49 |