SIMILAR PATTERNS OF AMINO ACIDS FOR 6F6S_B_CXQB705_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fpz CYCLIN-DEPENDENT
KINASE INHIBITOR 3

(Homo sapiens) 		PF05706
(CDKN3) 		4 VAL A  37
LEU A  34
LEU A  32
LEU A 126
 None
 0.91A 6f6sA-1fpzA:
0.0
6f6sB-1fpzA:
0.0		 6f6sA-1fpzA:
16.51
6f6sB-1fpzA:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gng GLYCOGEN SYNTHASE
KINASE-3 BETA

(Homo sapiens) 		PF00069
(Pkinase) 		4 LEU A 169
LEU A 165
TYR A 222
LEU A 320
 None
 1.06A 6f6sA-1gngA:
0.0
6f6sB-1gngA:
0.0		 6f6sA-1gngA:
10.85
6f6sB-1gngA:
9.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1obb ALPHA-GLUCOSIDASE

(Thermotoga
maritima) 		PF02056
(Glyco_hydro_4)
PF11975
(Glyco_hydro_4C) 		4 VAL A  35
LEU A  37
LEU A  49
LEU A  18
 None
 1.05A 6f6sA-1obbA:
0.0
6f6sB-1obbA:
undetectable		 6f6sA-1obbA:
11.70
6f6sB-1obbA:
10.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1odo PUTATIVE CYTOCHROME
P450 154A1

(Streptomyces
coelicolor) 		PF00067
(p450) 		4 VAL A 126
LEU A 144
LEU A 140
LEU A 368
 None
 0.70A 6f6sA-1odoA:
0.0
6f6sB-1odoA:
0.0		 6f6sA-1odoA:
10.29
6f6sB-1odoA:
14.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ofe FERREDOXIN-DEPENDENT
GLUTAMATE SYNTHASE 2

(Synechocystis
sp. PCC 6803) 		PF00310
(GATase_2)
PF01493
(GXGXG)
PF01645
(Glu_synthase)
PF04898
(Glu_syn_central) 		4 VAL A 591
LEU A 598
LEU A 640
LEU A 583
 None
 0.98A 6f6sA-1ofeA:
0.0
6f6sB-1ofeA:
0.0		 6f6sA-1ofeA:
4.37
6f6sB-1ofeA:
5.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qfx PROTEIN (PH 2.5 ACID
PHOSPHATASE)

(Aspergillus
niger) 		PF00328
(His_Phos_2) 		4 LEU A 389
LEU A 384
TYR A 349
LEU A 329
 None
 1.01A 6f6sA-1qfxA:
0.0
6f6sB-1qfxA:
0.0		 6f6sA-1qfxA:
10.00
6f6sB-1qfxA:
12.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qho ALPHA-AMYLASE

(Geobacillus
stearothermophilus) 		PF00128
(Alpha-amylase)
PF00686
(CBM_20)
PF01833
(TIG)
PF02806
(Alpha-amylase_C) 		4 VAL A  10
LEU A 351
LEU A 347
TYR A  12
 None
 1.04A 6f6sA-1qhoA:
0.0
6f6sB-1qhoA:
0.0		 6f6sA-1qhoA:
7.53
6f6sB-1qhoA:
8.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tex STF0
SULFOTRANSFERASE

(Mycolicibacterium
smegmatis) 		PF09037
(Sulphotransf) 		4 VAL A 132
LEU A   9
LEU A 138
LEU A 124
 None
 1.08A 6f6sA-1texA:
undetectable
6f6sB-1texA:
undetectable		 6f6sA-1texA:
15.52
6f6sB-1texA:
12.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1url SIALOADHESIN

(Mus musculus) 		PF07686
(V-set) 		4 VAL A  10
LEU A  86
TYR A  94
LEU A  82
 None
 1.04A 6f6sA-1urlA:
undetectable
6f6sB-1urlA:
undetectable		 6f6sA-1urlA:
18.18
6f6sB-1urlA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vs3 TRNA PSEUDOURIDINE
SYNTHASE A

(Thermus
thermophilus) 		PF01416
(PseudoU_synth_1) 		4 VAL A 116
LEU A 135
LEU A 137
LEU A 186
 None
 1.07A 6f6sA-1vs3A:
undetectable
6f6sB-1vs3A:
0.0		 6f6sA-1vs3A:
14.61
6f6sB-1vs3A:
13.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wws HYPOTHETICAL PROTEIN
TTHA1479

(Thermus
thermophilus) 		PF09123
(DUF1931) 		4 VAL A  85
LEU A  36
LEU A  40
LEU A 106
 None
 1.04A 6f6sA-1wwsA:
undetectable
6f6sB-1wwsA:
undetectable		 6f6sA-1wwsA:
24.65
6f6sB-1wwsA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wyt GLYCINE
DEHYDROGENASE
(DECARBOXYLATING)
SUBUNIT 1

(Thermus
thermophilus) 		PF02347
(GDC-P) 		4 VAL A 389
LEU A 433
LEU A 429
LEU A 380
 None
 0.97A 6f6sA-1wytA:
undetectable
6f6sB-1wytA:
0.0		 6f6sA-1wytA:
15.88
6f6sB-1wytA:
12.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x0h RAS
GTPASE-ACTIVATING-LI
KE PROTEIN IQGAP1

(Homo sapiens) 		no annotation 4 VAL A  22
LEU A  98
LEU A  99
LEU A  10
 None
 1.07A 6f6sA-1x0hA:
undetectable
6f6sB-1x0hA:
undetectable		 6f6sA-1x0hA:
20.17
6f6sB-1x0hA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xdp POLYPHOSPHATE KINASE

(Escherichia
coli) 		PF02503
(PP_kinase)
PF13089
(PP_kinase_N)
PF13090
(PP_kinase_C) 		4 VAL A 559
LEU A 535
LEU A 540
LEU A 514
 None
 0.83A 6f6sA-1xdpA:
undetectable
6f6sB-1xdpA:
0.0		 6f6sA-1xdpA:
7.01
6f6sB-1xdpA:
7.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z26 ARGONAUTE

(Pyrococcus
furiosus) 		PF02171
(Piwi)
PF12212
(PAZ_siRNAbind) 		4 VAL A 534
LEU A 538
LEU A 415
MET A 384
 None
 0.99A 6f6sA-1z26A:
0.2
6f6sB-1z26A:
undetectable		 6f6sA-1z26A:
7.48
6f6sB-1z26A:
7.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zki HYPOTHETICAL PROTEIN
PA5202

(Pseudomonas
aeruginosa) 		PF03061
(4HBT) 		4 VAL A 119
LEU A  52
LEU A  55
LEU A  40
 None
 1.00A 6f6sA-1zkiA:
undetectable
6f6sB-1zkiA:
undetectable		 6f6sA-1zkiA:
23.58
6f6sB-1zkiA:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c1c CARBOXYPEPTIDASE B

(Helicoverpa zea) 		PF00246
(Peptidase_M14) 		4 LEU A 274
LEU A 281
TYR A 238
LEU A 235
 None
 0.94A 6f6sA-2c1cA:
undetectable
6f6sB-2c1cA:
undetectable		 6f6sA-2c1cA:
15.72
6f6sB-2c1cA:
13.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dqw DIHYDROPTEROATE
SYNTHASE

(Thermus
thermophilus) 		PF00809
(Pterin_bind) 		4 VAL A 195
LEU A 266
LEU A  32
LEU A  24
 None
 0.62A 6f6sA-2dqwA:
undetectable
6f6sB-2dqwA:
undetectable		 6f6sA-2dqwA:
15.38
6f6sB-2dqwA:
13.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dvl ACYL-COA
DEHYDROGENASE

(Thermus
thermophilus) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		4 VAL A  85
LEU A  74
LEU A  22
LEU A  46
 None
 0.91A 6f6sA-2dvlA:
undetectable
6f6sB-2dvlA:
undetectable		 6f6sA-2dvlA:
11.02
6f6sB-2dvlA:
12.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e1f WERNER SYNDROME
ATP-DEPENDENT
HELICASE

(Homo sapiens) 		PF00570
(HRDC) 		4 VAL A1204
LEU A1212
LEU A1216
LEU A1160
 None
 0.94A 6f6sA-2e1fA:
undetectable
6f6sB-2e1fA:
undetectable		 6f6sA-2e1fA:
25.89
6f6sB-2e1fA:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2elc ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE

(Thermus
thermophilus) 		PF00591
(Glycos_transf_3)
PF02885
(Glycos_trans_3N) 		4 VAL A 324
LEU A 320
LEU A  95
LEU A 121
 None
 1.06A 6f6sA-2elcA:
undetectable
6f6sB-2elcA:
undetectable		 6f6sA-2elcA:
17.21
6f6sB-2elcA:
10.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f1z UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 7

(Homo sapiens) 		PF00443
(UCH)
PF00917
(MATH) 		4 VAL A 263
LEU A 260
LEU A 303
LEU A 238
 None
 0.82A 6f6sA-2f1zA:
undetectable
6f6sB-2f1zA:
undetectable		 6f6sA-2f1zA:
10.29
6f6sB-2f1zA:
9.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gi7 GPVI PROTEIN

(Homo sapiens) 		PF13895
(Ig_2) 		4 VAL A  18
LEU A  85
LEU A  83
LEU A  53
 None
None
None
SO4  A 204 (-3.8A)
 1.06A 6f6sA-2gi7A:
undetectable
6f6sB-2gi7A:
undetectable		 6f6sA-2gi7A:
21.74
6f6sB-2gi7A:
16.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i7x PROTEIN CFT2

(Saccharomyces
cerevisiae) 		PF16661
(Lactamase_B_6) 		4 VAL A 175
LEU A 676
TYR A 154
LEU A 194
 None
 1.02A 6f6sA-2i7xA:
undetectable
6f6sB-2i7xA:
undetectable		 6f6sA-2i7xA:
9.41
6f6sB-2i7xA:
8.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mks RNA-BINDING MOTIF
PROTEIN, X
CHROMOSOME

(Homo sapiens) 		PF00076
(RRM_1) 		4 VAL A  56
LEU A  26
MET A  71
LEU A  76
 None
 0.92A 6f6sA-2mksA:
undetectable
6f6sB-2mksA:
undetectable		 6f6sA-2mksA:
23.91
6f6sB-2mksA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o3c APEX NUCLEASE 1

(Danio rerio) 		PF03372
(Exo_endo_phos) 		4 VAL A  69
LEU A  65
LEU A  87
MET A 104
 None
 1.03A 6f6sA-2o3cA:
undetectable
6f6sB-2o3cA:
undetectable		 6f6sA-2o3cA:
15.06
6f6sB-2o3cA:
13.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o5v DNA REPLICATION AND
REPAIR PROTEIN RECF

(Deinococcus
radiodurans) 		PF02463
(SMC_N) 		4 VAL A  72
LEU A   9
LEU A   6
LEU A  43
 None
 0.80A 6f6sA-2o5vA:
undetectable
6f6sB-2o5vA:
0.0		 6f6sA-2o5vA:
12.20
6f6sB-2o5vA:
13.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p62 HYPOTHETICAL PROTEIN
PH0156

(Pyrococcus
horikoshii) 		PF11536
(DUF3226) 		4 VAL A 108
LEU A  75
LEU A  79
LEU A   5
 None
 0.98A 6f6sA-2p62A:
undetectable
6f6sB-2p62A:
undetectable		 6f6sA-2p62A:
15.88
6f6sB-2p62A:
14.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q5w MOLYBDOPTERIN
CONVERTING FACTOR,
SUBUNIT 1

(Staphylococcus
aureus) 		PF02597
(ThiS) 		4 VAL D  49
LEU D  35
MET D   1
LEU D  26
 None
 1.07A 6f6sA-2q5wD:
undetectable
6f6sB-2q5wD:
undetectable		 6f6sA-2q5wD:
19.77
6f6sB-2q5wD:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rsp RSV PROTEASE

(Rous sarcoma
virus) 		PF00077
(RVP) 		4 VAL A  13
LEU A 109
LEU A 114
LEU A  95
 None
 1.05A 6f6sA-2rspA:
undetectable
6f6sB-2rspA:
undetectable		 6f6sA-2rspA:
19.83
6f6sB-2rspA:
24.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vpw THIOSULFATE
REDUCTASE

(Thermus
thermophilus) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF04879
(Molybdop_Fe4S4) 		4 VAL A 235
LEU A 260
LEU A 261
MET A 319
 MGD  A1766 (-4.5A)
None
None
None
 0.97A 6f6sA-2vpwA:
undetectable
6f6sB-2vpwA:
undetectable		 6f6sA-2vpwA:
7.82
6f6sB-2vpwA:
7.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wxz ANGIOTENSINOGEN

(Rattus
norvegicus) 		PF00079
(Serpin) 		4 VAL A 301
LEU A 311
LEU A 424
LEU A 351
 None
 1.05A 6f6sA-2wxzA:
undetectable
6f6sB-2wxzA:
undetectable		 6f6sA-2wxzA:
11.85
6f6sB-2wxzA:
10.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y4t DNAJ HOMOLOG
SUBFAMILY C MEMBER 3

(Homo sapiens) 		PF00226
(DnaJ)
PF09976
(TPR_21)
PF13181
(TPR_8) 		4 VAL A 183
LEU A 116
LEU A 121
LEU A 148
 None
 0.81A 6f6sA-2y4tA:
undetectable
6f6sB-2y4tA:
undetectable		 6f6sA-2y4tA:
13.02
6f6sB-2y4tA:
10.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z23 PERIPLASMIC
OLIGOPEPTIDE-BINDING
PROTEIN

(Yersinia pestis) 		PF00496
(SBP_bac_5) 		4 VAL A 152
LEU A 158
LEU A 159
LEU A 113
 None
 0.83A 6f6sA-2z23A:
undetectable
6f6sB-2z23A:
undetectable		 6f6sA-2z23A:
10.47
6f6sB-2z23A:
9.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zet RAS-RELATED PROTEIN
RAB-27B

(Mus musculus) 		PF00071
(Ras) 		4 VAL A  51
LEU A  70
LEU A  72
LEU A 177
 None
 0.66A 6f6sA-2zetA:
undetectable
6f6sB-2zetA:
undetectable		 6f6sA-2zetA:
17.92
6f6sB-2zetA:
13.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zxo SINGLE-STRANDED DNA
SPECIFIC EXONUCLEASE
RECJ

(Thermus
thermophilus) 		PF01368
(DHH)
PF02272
(DHHA1) 		4 VAL A 601
LEU A 650
TYR A 560
LEU A 605
 None
 1.02A 6f6sA-2zxoA:
undetectable
6f6sB-2zxoA:
undetectable		 6f6sA-2zxoA:
8.78
6f6sB-2zxoA:
7.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a14 1-DEOXY-D-XYLULOSE
5-PHOSPHATE
REDUCTOISOMERASE

(Thermotoga
maritima) 		PF02670
(DXP_reductoisom)
PF08436
(DXP_redisom_C)
PF13288
(DXPR_C) 		4 VAL A 353
LEU A  99
LEU A 103
LEU A 120
 None
 0.89A 6f6sA-3a14A:
undetectable
6f6sB-3a14A:
undetectable		 6f6sA-3a14A:
11.48
6f6sB-3a14A:
12.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bmb REGULATOR OF
NUCLEOSIDE
DIPHOSPHATE KINASE

(Escherichia
coli) 		PF01272
(GreA_GreB)
PF14760
(Rnk_N) 		4 LEU A  34
LEU A  38
TYR A  77
MET A  56
 None
None
SO4  A 137 (-4.7A)
None
 1.08A 6f6sA-3bmbA:
undetectable
6f6sB-3bmbA:
undetectable		 6f6sA-3bmbA:
20.44
6f6sB-3bmbA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dhn NAD-DEPENDENT
EPIMERASE/DEHYDRATAS
E

(Bacteroides
thetaiotaomicron) 		PF13460
(NAD_binding_10) 		4 VAL A   4
LEU A 205
LEU A 108
LEU A   9
 None
 0.99A 6f6sA-3dhnA:
undetectable
6f6sB-3dhnA:
undetectable		 6f6sA-3dhnA:
20.10
6f6sB-3dhnA:
16.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dqq PUTATIVE TRNA
SYNTHASE

(Salmonella
enterica) 		PF07005
(DUF1537)
PF17042
(DUF1357_C) 		4 VAL A  98
LEU A 102
LEU A 218
TYR A  83
 None
 0.98A 6f6sA-3dqqA:
undetectable
6f6sB-3dqqA:
undetectable		 6f6sA-3dqqA:
12.06
6f6sB-3dqqA:
11.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e23 UNCHARACTERIZED
PROTEIN RPA2492

(Rhodopseudomonas
palustris) 		PF08241
(Methyltransf_11) 		4 VAL A 106
LEU A  50
LEU A 112
LEU A 126
 None
 1.00A 6f6sA-3e23A:
undetectable
6f6sB-3e23A:
undetectable		 6f6sA-3e23A:
18.23
6f6sB-3e23A:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f41 PHYTASE

(Mitsuokella
multacida) 		PF14566
(PTPlike_phytase) 		4 VAL A 127
LEU A 217
LEU A 219
MET A 263
 None
 0.86A 6f6sA-3f41A:
undetectable
6f6sB-3f41A:
undetectable		 6f6sA-3f41A:
8.51
6f6sB-3f41A:
9.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gsi N,N-DIMETHYLGLYCINE
OXIDASE

(Arthrobacter
globiformis) 		PF01266
(DAO)
PF01571
(GCV_T)
PF08669
(GCV_T_C)
PF16350
(FAO_M) 		4 VAL A  92
LEU A 131
LEU A 319
LEU A 248
 None
 0.93A 6f6sA-3gsiA:
undetectable
6f6sB-3gsiA:
undetectable		 6f6sA-3gsiA:
8.68
6f6sB-3gsiA:
7.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ie1 RIBONUCLEASE
TTHA0252

(Thermus
thermophilus) 		PF00753
(Lactamase_B)
PF07521
(RMMBL)
PF10996
(Beta-Casp) 		4 VAL A 148
LEU A  56
LEU A 121
LEU A 129
 None
None
None
SO4  A 434 (-4.1A)
 1.07A 6f6sA-3ie1A:
undetectable
6f6sB-3ie1A:
undetectable		 6f6sA-3ie1A:
11.16
6f6sB-3ie1A:
9.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l7o RIBOSE-5-PHOSPHATE
ISOMERASE A

(Streptococcus
mutans) 		PF06026
(Rib_5-P_isom_A) 		4 VAL A 134
LEU A 176
LEU A 178
MET A 190
 None
 0.97A 6f6sA-3l7oA:
undetectable
6f6sB-3l7oA:
undetectable		 6f6sA-3l7oA:
16.11
6f6sB-3l7oA:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m9u FARNESYL-DIPHOSPHATE
SYNTHASE

(Lactobacillus
brevis) 		PF00348
(polyprenyl_synt) 		4 VAL A  43
LEU A 122
LEU A 125
LEU A  35
 None
 1.07A 6f6sA-3m9uA:
undetectable
6f6sB-3m9uA:
undetectable		 6f6sA-3m9uA:
14.05
6f6sB-3m9uA:
14.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mi9 CELL DIVISION
PROTEIN KINASE 9

(Homo sapiens) 		PF00069
(Pkinase) 		4 LEU A 137
LEU A 133
TYR A 194
LEU A 295
 None
 0.88A 6f6sA-3mi9A:
undetectable
6f6sB-3mi9A:
undetectable		 6f6sA-3mi9A:
13.53
6f6sB-3mi9A:
11.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mnf PAC2 FAMILY PROTEIN

(Streptomyces
avermitilis) 		PF09754
(PAC2) 		4 VAL A  84
LEU A  92
LEU A  94
LEU A 209
 None
 0.73A 6f6sA-3mnfA:
undetectable
6f6sB-3mnfA:
undetectable		 6f6sA-3mnfA:
18.50
6f6sB-3mnfA:
14.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nv0 NTF2-RELATED EXPORT
PROTEIN
NUCLEAR RNA EXPORT
FACTOR 2

(Caenorhabditis
elegans) 		PF02136
(NTF2)
no annotation 		4 VAL B  87
LEU A 331
LEU A 326
LEU B  96
 PEG  B1004 (-3.3A)
PEG  B1004 ( 4.1A)
None
None
 1.00A 6f6sA-3nv0B:
undetectable
6f6sB-3nv0B:
undetectable		 6f6sA-3nv0B:
17.09
6f6sB-3nv0B:
16.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pb9 GLUTAMINYL-PEPTIDE
CYCLOTRANSFERASE-LIK
E PROTEIN

(Homo sapiens) 		PF04389
(Peptidase_M28) 		4 VAL X  84
LEU X 201
LEU X 197
LEU X 380
 None
 0.89A 6f6sA-3pb9X:
undetectable
6f6sB-3pb9X:
undetectable		 6f6sA-3pb9X:
14.37
6f6sB-3pb9X:
13.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qty PHOSPHORIBOSYLAMINOI
MIDAZOLE (AIR)
SYNTHETASE

(Francisella
tularensis) 		PF00586
(AIRS)
PF02769
(AIRS_C) 		4 VAL A  73
LEU A 225
LEU A 189
LEU A 200
 None
 1.07A 6f6sA-3qtyA:
undetectable
6f6sB-3qtyA:
undetectable		 6f6sA-3qtyA:
14.12
6f6sB-3qtyA:
11.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rk6 POLYADENYLATE-BINDIN
G
PROTEIN-INTERACTING
PROTEIN 1

(Homo sapiens) 		PF02854
(MIF4G) 		4 VAL A  83
LEU A 108
LEU A 146
LEU A 118
 None
 1.04A 6f6sA-3rk6A:
undetectable
6f6sB-3rk6A:
undetectable		 6f6sA-3rk6A:
18.31
6f6sB-3rk6A:
14.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3s88 ENVELOPE
GLYCOPROTEIN

(Sudan
ebolavirus) 		PF01611
(Filo_glycop)
no annotation 		4 VAL I  66
LEU I 184
LEU I 186
TYR J 517
 None
 0.65A 6f6sA-3s88I:
28.4
6f6sB-3s88I:
undetectable		 6f6sA-3s88I:
74.39
6f6sB-3s88I:
14.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ts7 GERANYLTRANSTRANSFER
ASE

(Methylococcus
capsulatus) 		PF00348
(polyprenyl_synt) 		4 VAL A  44
LEU A 121
LEU A 124
LEU A  36
 None
 1.05A 6f6sA-3ts7A:
undetectable
6f6sB-3ts7A:
undetectable		 6f6sA-3ts7A:
15.33
6f6sB-3ts7A:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u9g ZINC FINGER
CCCH-TYPE ANTIVIRAL
PROTEIN 1

(Rattus
norvegicus) 		no annotation 4 VAL A  64
LEU A  26
LEU A  27
LEU A  40
 None
 0.88A 6f6sA-3u9gA:
undetectable
6f6sB-3u9gA:
undetectable		 6f6sA-3u9gA:
17.03
6f6sB-3u9gA:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b29 DIMETHYLSULFONIOPROP
IONATE LYASE

(Roseovarius
nubinhibens) 		PF16867
(DMSP_lyase) 		4 VAL A 113
LEU A 180
LEU A  64
LEU A  21
 None
 1.06A 6f6sA-4b29A:
undetectable
6f6sB-4b29A:
undetectable		 6f6sA-4b29A:
14.95
6f6sB-4b29A:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bed HEMOCYANIN KLH1

(Megathura
crenulata) 		PF00264
(Tyrosinase)
PF14830
(Haemocyan_bet_s) 		4 VAL A1338
LEU A1273
LEU A1270
LEU A1453
 None
 1.06A 6f6sA-4bedA:
undetectable
6f6sB-4bedA:
undetectable		 6f6sA-4bedA:
4.03
6f6sB-4bedA:
4.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4db3 N-ACETYL-D-GLUCOSAMI
NE KINASE

(Vibrio
vulnificus) 		PF00480
(ROK) 		4 VAL A  80
LEU A  64
LEU A  62
TYR A  36
 None
 1.05A 6f6sA-4db3A:
undetectable
6f6sB-4db3A:
undetectable		 6f6sA-4db3A:
12.65
6f6sB-4db3A:
13.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dwl BBP7

(Bordetella
virus BPP1) 		no annotation 4 VAL A 109
LEU A  75
LEU A  78
LEU A  55
 None
 0.78A 6f6sA-4dwlA:
undetectable
6f6sB-4dwlA:
undetectable		 6f6sA-4dwlA:
22.56
6f6sB-4dwlA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ekd GUANINE
NUCLEOTIDE-BINDING
PROTEIN G(Q) SUBUNIT
ALPHA

(Mus musculus) 		PF00503
(G-alpha) 		4 VAL A 199
LEU A  40
LEU A  42
LEU A 351
 None
 0.90A 6f6sA-4ekdA:
undetectable
6f6sB-4ekdA:
undetectable		 6f6sA-4ekdA:
12.20
6f6sB-4ekdA:
13.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eqf PEX5-RELATED PROTEIN

(Mus musculus) 		PF13181
(TPR_8)
PF13432
(TPR_16) 		4 LEU A 259
LEU A 317
MET A 294
LEU A 299
 None
 1.06A 6f6sA-4eqfA:
undetectable
6f6sB-4eqfA:
undetectable		 6f6sA-4eqfA:
14.41
6f6sB-4eqfA:
12.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ewt PEPTIDASE,
M20/M25/M40 FAMILY

(Staphylococcus
aureus) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		4 VAL A 235
LEU A 219
LEU A 277
LEU A 190
 None
 1.07A 6f6sA-4ewtA:
undetectable
6f6sB-4ewtA:
0.0		 6f6sA-4ewtA:
11.14
6f6sB-4ewtA:
10.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f0b THIOL TRANSFERASE

(Phanerochaete
chrysosporium) 		PF00043
(GST_C)
PF02798
(GST_N) 		4 VAL A   9
LEU A  26
LEU A  29
LEU A  88
 None
 1.04A 6f6sA-4f0bA:
undetectable
6f6sB-4f0bA:
undetectable		 6f6sA-4f0bA:
18.82
6f6sB-4f0bA:
14.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fxc FERREDOXIN

(Arthrospira
platensis) 		PF00111
(Fer2) 		4 VAL A   5
LEU A   7
LEU A  35
LEU A  27
 None
 0.87A 6f6sA-4fxcA:
undetectable
6f6sB-4fxcA:
undetectable		 6f6sA-4fxcA:
21.11
6f6sB-4fxcA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i3u ALDEHYDE
DEHYDROGENASE (NAD+)

(Sinorhizobium
meliloti) 		PF00171
(Aldedh) 		4 VAL A 178
LEU A 207
LEU A 202
LEU A 193
 None
 1.05A 6f6sA-4i3uA:
undetectable
6f6sB-4i3uA:
undetectable		 6f6sA-4i3uA:
12.87
6f6sB-4i3uA:
10.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ix3 MSSTT7D PROTEIN

(Micromonas
commoda) 		PF00069
(Pkinase) 		4 LEU A 306
LEU A 302
TYR A 365
LEU A 468
 None
 1.06A 6f6sA-4ix3A:
undetectable
6f6sB-4ix3A:
0.1		 6f6sA-4ix3A:
13.62
6f6sB-4ix3A:
12.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j7q PHOSPHATIDYLINOSITOL
TRANSFER PROTEIN
PDR16

(Saccharomyces
cerevisiae) 		PF00650
(CRAL_TRIO)
PF03765
(CRAL_TRIO_N) 		4 VAL A 184
LEU A 158
LEU A 197
LEU A 177
 None
None
B7N  A 401 (-4.6A)
B7N  A 401 (-4.3A)
 1.07A 6f6sA-4j7qA:
undetectable
6f6sB-4j7qA:
undetectable		 6f6sA-4j7qA:
13.74
6f6sB-4j7qA:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kt3 UNCHARACTERIZED
PROTEIN

(Pseudomonas
protegens) 		PF01832
(Glucosaminidase) 		4 VAL A 129
LEU A  57
LEU A  62
TYR A 147
 None
 1.08A 6f6sA-4kt3A:
undetectable
6f6sB-4kt3A:
undetectable		 6f6sA-4kt3A:
22.44
6f6sB-4kt3A:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mp4 GLUTATHIONE
S-TRANSFERASE

(Acinetobacter
baumannii) 		PF13417
(GST_N_3)
PF14834
(GST_C_4) 		4 VAL A  23
LEU A  63
LEU A  70
LEU A  83
 None
 0.95A 6f6sA-4mp4A:
undetectable
6f6sB-4mp4A:
undetectable		 6f6sA-4mp4A:
17.79
6f6sB-4mp4A:
15.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nkh E3 UBIQUITIN-PROTEIN
LIGASE SSPH1

(Salmonella
enterica) 		no annotation 4 VAL A 284
LEU A 289
LEU A 309
MET A 295
 None
 0.87A 6f6sA-4nkhA:
undetectable
6f6sB-4nkhA:
undetectable		 6f6sA-4nkhA:
15.19
6f6sB-4nkhA:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o2h PROTEIN BCAM1869

(Burkholderia
cenocepacia) 		PF16245
(DUF4902) 		4 VAL A  18
LEU A  20
LEU A  28
TYR A  70
 None
 1.07A 6f6sA-4o2hA:
undetectable
6f6sB-4o2hA:
undetectable		 6f6sA-4o2hA:
19.33
6f6sB-4o2hA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oiy PROTEIN TRANSPORT
PROTEIN SEC7

(Saccharomyces
cerevisiae) 		PF01369
(Sec7) 		4 VAL A 908
LEU A 959
LEU A 962
LEU A 998
 None
 1.08A 6f6sA-4oiyA:
undetectable
6f6sB-4oiyA:
undetectable		 6f6sA-4oiyA:
17.28
6f6sB-4oiyA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p52 HOMOSERINE KINASE

(Cytophaga
hutchinsonii) 		PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C) 		4 VAL A  16
LEU A 210
LEU A 214
LEU A 255
 None
 1.00A 6f6sA-4p52A:
undetectable
6f6sB-4p52A:
undetectable		 6f6sA-4p52A:
14.43
6f6sB-4p52A:
13.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r6g LEUCINE RICH REPEATS
DLRR_K

(synthetic
construct) 		PF12799
(LRR_4)
PF13516
(LRR_6)
PF13855
(LRR_8) 		4 VAL A 328
LEU A 304
LEU A 310
LEU A 291
 None
 1.06A 6f6sA-4r6gA:
undetectable
6f6sB-4r6gA:
undetectable		 6f6sA-4r6gA:
11.37
6f6sB-4r6gA:
8.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r6j LUCINE RICH REPEATS
DLRR_H

(synthetic
construct) 		PF00560
(LRR_1)
PF12354
(Internalin_N)
PF13855
(LRR_8) 		4 VAL A 103
LEU A  80
LEU A  89
LEU A  74
 None
 0.96A 6f6sA-4r6jA:
undetectable
6f6sB-4r6jA:
undetectable		 6f6sA-4r6jA:
15.61
6f6sB-4r6jA:
14.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r8g UNCONVENTIONAL
MYOSIN-IC

(Mus musculus) 		PF00612
(IQ)
PF06017
(Myosin_TH1) 		4 VAL E 912
LEU E 905
LEU E 959
LEU E 968
 None
 1.03A 6f6sA-4r8gE:
undetectable
6f6sB-4r8gE:
undetectable		 6f6sA-4r8gE:
12.91
6f6sB-4r8gE:
13.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uie SURFACE LAYER
PROTEIN

(Geobacillus
stearothermophilus) 		no annotation 4 VAL A 876
LEU A 859
LEU A 861
LEU A 783
 None
 1.07A 6f6sA-4uieA:
undetectable
6f6sB-4uieA:
undetectable		 6f6sA-4uieA:
13.58
6f6sB-4uieA:
14.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uob ENDONUCLEASE III-3

(Deinococcus
radiodurans) 		PF00730
(HhH-GPD) 		4 VAL A 228
LEU A 128
LEU A 202
LEU A 190
 ACT  A1335 ( 4.7A)
None
None
None
 1.05A 6f6sA-4uobA:
undetectable
6f6sB-4uobA:
undetectable		 6f6sA-4uobA:
15.50
6f6sB-4uobA:
14.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wts BETA-1,3-GLUCANOSYLT
RANSFERASE

(Rhizomucor
miehei) 		PF00332
(Glyco_hydro_17) 		4 VAL A 118
LEU A  79
LEU A  83
LEU A  62
 None
 0.90A 6f6sA-4wtsA:
undetectable
6f6sB-4wtsA:
undetectable		 6f6sA-4wtsA:
14.81
6f6sB-4wtsA:
13.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z8y RAS-RELATED PROTEIN
SEC4

(Saccharomyces
cerevisiae) 		PF00071
(Ras) 		4 VAL A  62
LEU A  71
LEU A  73
LEU A 176
 None
 0.71A 6f6sA-4z8yA:
undetectable
6f6sB-4z8yA:
undetectable		 6f6sA-4z8yA:
18.71
6f6sB-4z8yA:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b71 SKY59 FAB HEAVY
CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 VAL B  49
LEU B  82
LEU B  20
MET B  87
 None
 1.07A 6f6sA-5b71B:
undetectable
6f6sB-5b71B:
undetectable		 6f6sA-5b71B:
15.25
6f6sB-5b71B:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5df0 AC-CHIA

(Autographa
californica
multiple
nucleopolyhedrovirus) 		PF00704
(Glyco_hydro_18)
PF08329
(ChitinaseA_N) 		4 VAL A 169
LEU A 174
LEU A 256
LEU A 178
 None
 0.87A 6f6sA-5df0A:
undetectable
6f6sB-5df0A:
undetectable		 6f6sA-5df0A:
10.49
6f6sB-5df0A:
11.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fyr PHOSPHOINOSITOL-SPEC
IFIC PHOSPHOLIPASE C

(Pseudomonas sp.) 		PF16670
(PI-PLC-C1) 		4 VAL A 101
LEU A 116
LEU A 186
LEU A  94
 None
 1.04A 6f6sA-5fyrA:
undetectable
6f6sB-5fyrA:
undetectable		 6f6sA-5fyrA:
15.07
6f6sB-5fyrA:
12.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gkx UNCHARACTERIZED
PROTEIN

(Thermococcus
onnurineus) 		PF14336
(DUF4392) 		4 VAL A 211
LEU A  38
LEU A  41
LEU A 203
 None
 0.81A 6f6sA-5gkxA:
undetectable
6f6sB-5gkxA:
undetectable		 6f6sA-5gkxA:
17.24
6f6sB-5gkxA:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gpr CHITINASE

(Ostrinia
furnacalis) 		PF00704
(Glyco_hydro_18)
PF08329
(ChitinaseA_N) 		4 VAL A 172
LEU A 177
LEU A 259
LEU A 181
 VAL  A 172 ( 0.6A)
LEU  A 177 ( 0.6A)
LEU  A 259 ( 0.6A)
LEU  A 181 ( 0.5A)
 0.82A 6f6sA-5gprA:
undetectable
6f6sB-5gprA:
undetectable		 6f6sA-5gprA:
11.09
6f6sB-5gprA:
9.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hop LMO0182 PROTEIN

(Listeria
monocytogenes) 		no annotation 4 VAL A  62
LEU A  66
LEU A  97
TYR A  54
 None
 0.98A 6f6sA-5hopA:
undetectable
6f6sB-5hopA:
undetectable		 6f6sA-5hopA:
15.32
6f6sB-5hopA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5irp ALANINE RACEMASE 2

(Bacillus
subtilis) 		PF00842
(Ala_racemase_C)
PF01168
(Ala_racemase_N) 		4 VAL A  67
LEU A 103
LEU A 127
LEU A  90
 None
 0.81A 6f6sA-5irpA:
undetectable
6f6sB-5irpA:
undetectable		 6f6sA-5irpA:
15.74
6f6sB-5irpA:
11.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ken EBOLA SURFACE
GLYCOPROTEIN, GP1
EBOLA SURFACE
GLYCOPROTEIN, GP2

(Zaire
ebolavirus) 		PF01611
(Filo_glycop)
no annotation 		4 VAL A  66
LEU A 184
LEU A 186
MET B 548
 None
 1.02A 6f6sA-5kenA:
23.6
6f6sB-5kenA:
undetectable		 6f6sA-5kenA:
98.67
6f6sB-5kenA:
15.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ken EBOLA SURFACE
GLYCOPROTEIN, GP1
EBOLA SURFACE
GLYCOPROTEIN, GP2

(Zaire
ebolavirus) 		PF01611
(Filo_glycop)
no annotation 		5 VAL A  66
LEU A 184
LEU A 186
TYR B 517
LEU B 554
 None
 0.86A 6f6sA-5kenA:
23.6
6f6sB-5kenA:
undetectable		 6f6sA-5kenA:
98.67
6f6sB-5kenA:
15.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m3x ANGIOTENSINOGEN

(Homo sapiens) 		no annotation 4 VAL A 301
LEU A 311
LEU A 423
LEU A 351
 None
 1.07A 6f6sA-5m3xA:
undetectable
6f6sB-5m3xA:
undetectable		 6f6sA-5m3xA:
24.44
6f6sB-5m3xA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nmi CYTOCHROME B-C1
COMPLEX SUBUNIT 1,
MITOCHONDRIAL

(Bos taurus) 		PF00675
(Peptidase_M16)
PF05193
(Peptidase_M16_C) 		4 VAL A 110
LEU A 197
LEU A  23
LEU A 209
 None
 1.02A 6f6sA-5nmiA:
undetectable
6f6sB-5nmiA:
0.3		 6f6sA-5nmiA:
11.76
6f6sB-5nmiA:
13.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ods CLATHRIN HEAVY CHAIN
1

(Mus musculus) 		no annotation 4 VAL A 467
LEU A 448
LEU A 452
LEU A 435
 None
 0.86A 6f6sA-5odsA:
undetectable
6f6sB-5odsA:
undetectable		 6f6sA-5odsA:
22.89
6f6sB-5odsA:
15.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5olt -

(-) 		no annotation 4 VAL A 250
LEU A 245
LEU A 395
LEU A 421
 None
 0.94A 6f6sA-5oltA:
undetectable
6f6sB-5oltA:
undetectable		 6f6sA-5oltA:
undetectable
6f6sB-5oltA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5sy1 STRA6

(Danio rerio) 		PF14752
(RBP_receptor) 		4 VAL A  96
LEU A 193
LEU A 164
TYR A 131
 None
 1.02A 6f6sA-5sy1A:
undetectable
6f6sB-5sy1A:
undetectable		 6f6sA-5sy1A:
8.40
6f6sB-5sy1A:
7.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uin FORMYLTRANSFERASE

(Salmonella
enterica) 		PF00551
(Formyl_trans_N)
PF13637
(Ank_4) 		4 VAL A 377
LEU A 367
LEU A 365
MET A 348
 None
 0.91A 6f6sA-5uinA:
undetectable
6f6sB-5uinA:
undetectable		 6f6sA-5uinA:
13.33
6f6sB-5uinA:
12.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w2f EUKARYOTIC
TRANSLATION
INITIATION FACTOR 2D

(Homo sapiens) 		PF01253
(SUI1) 		4 VAL A 433
LEU A 460
LEU A 461
LEU A 394
 None
 1.01A 6f6sA-5w2fA:
undetectable
6f6sB-5w2fA:
undetectable		 6f6sA-5w2fA:
19.13
6f6sB-5w2fA:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w8q BIS3 BIPHENYL
SYNTHASE

(Malus domestica) 		no annotation 4 VAL A 184
LEU A 139
LEU A 145
LEU A 106
 None
 1.00A 6f6sA-5w8qA:
0.0
6f6sB-5w8qA:
undetectable		 6f6sA-5w8qA:
19.28
6f6sB-5w8qA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y7o UGGT

(Thermomyces
dupontii) 		PF06427
(UDP-g_GGTase) 		4 VAL A 813
LEU A 822
LEU A 714
MET A 700
 None
 0.81A 6f6sA-5y7oA:
undetectable
6f6sB-5y7oA:
undetectable		 6f6sA-5y7oA:
5.68
6f6sB-5y7oA:
5.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6a70 -

(-) 		no annotation 4 LEU B3286
LEU B3565
TYR B3334
LEU B3341
 None
 1.06A 6f6sA-6a70B:
undetectable
6f6sB-6a70B:
0.0		 6f6sA-6a70B:
undetectable
6f6sB-6a70B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bu3 BETA-LACTAMASE

(Escherichia
coli) 		no annotation 4 VAL A  95
LEU A 119
LEU A  90
LEU A 142
 None
 0.93A 6f6sA-6bu3A:
undetectable
6f6sB-6bu3A:
undetectable		 6f6sA-6bu3A:
21.74
6f6sB-6bu3A:
17.05