SIMILAR PATTERNS OF AMINO ACIDS FOR 6F6S_A_CXQA507_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bev BOVINE ENTEROVIRUS
COAT PROTEINS VP1 TO
VP4

(Enterovirus E) 		PF00073
(Rhv) 		4 ALA 3  79
TYR 3 198
GLN 3  80
ILE 3 196
 None
 1.22A 6f6sA-1bev3:
0.0
6f6sB-1bev3:
0.0		 6f6sA-1bev3:
17.52
6f6sB-1bev3:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cg4 PROTEIN
(ADENYLOSUCCINATE
SYNTHETASE)

(Escherichia
coli) 		PF00709
(Adenylsucc_synt) 		4 ARG A 117
ALA A 112
TYR A 109
ILE A 106
 None
 1.24A 6f6sA-1cg4A:
0.0
6f6sB-1cg4A:
0.0		 6f6sA-1cg4A:
11.25
6f6sB-1cg4A:
11.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e4o MALTODEXTRIN
PHOSPHORYLASE

(Escherichia
coli) 		PF00343
(Phosphorylase) 		4 ALA A 572
TYR A 613
GLN A 531
ILE A 530
 None
PLP  A 999 ( 4.7A)
None
None
 1.21A 6f6sA-1e4oA:
0.0
6f6sB-1e4oA:
0.0		 6f6sA-1e4oA:
8.74
6f6sB-1e4oA:
7.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eyw PHOSPHOTRIESTERASE

(Brevundimonas
diminuta) 		PF02126
(PTE) 		4 ARG A 246
ALA A 242
TYR A 239
ILE A 250
 None
 1.18A 6f6sA-1eywA:
0.0
6f6sB-1eywA:
undetectable		 6f6sA-1eywA:
13.68
6f6sB-1eywA:
14.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mky PROBABLE GTP-BINDING
PROTEIN ENGA

(Thermotoga
maritima) 		PF01926
(MMR_HSR1)
PF14714
(KH_dom-like) 		4 ARG A 293
ALA A 294
TYR A 353
ILE A 392
 None
 1.12A 6f6sA-1mkyA:
0.0
6f6sB-1mkyA:
0.0		 6f6sA-1mkyA:
11.75
6f6sB-1mkyA:
11.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r5m SIR4-INTERACTING
PROTEIN SIF2

(Saccharomyces
cerevisiae) 		PF00400
(WD40)
PF12894
(ANAPC4_WD40) 		4 ARG A 449
ALA A 458
TYR A 457
ILE A 445
 None
 1.33A 6f6sA-1r5mA:
0.0
6f6sB-1r5mA:
0.0		 6f6sA-1r5mA:
10.75
6f6sB-1r5mA:
12.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rqj GERANYLTRANSTRANSFER
ASE

(Escherichia
coli) 		PF00348
(polyprenyl_synt) 		4 ARG A 292
ALA A 291
TYR A 232
ILE A 315
 None
 1.26A 6f6sA-1rqjA:
undetectable
6f6sB-1rqjA:
undetectable		 6f6sA-1rqjA:
17.36
6f6sB-1rqjA:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s6i CALCIUM-DEPENDENT
PROTEIN KINASE SK5

(Glycine max) 		PF13499
(EF-hand_7) 		4 ARG A 143
ALA A 139
TYR A 135
ILE A 151
 None
 1.17A 6f6sA-1s6iA:
undetectable
6f6sB-1s6iA:
undetectable		 6f6sA-1s6iA:
16.57
6f6sB-1s6iA:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sb8 WBPP

(Pseudomonas
aeruginosa) 		PF01370
(Epimerase) 		4 ARG A 192
ALA A 141
TYR A 139
ILE A 189
 None
 1.31A 6f6sA-1sb8A:
0.0
6f6sB-1sb8A:
undetectable		 6f6sA-1sb8A:
13.81
6f6sB-1sb8A:
12.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t2w SORTASE

(Staphylococcus
aureus) 		PF04203
(Sortase) 		4 ALA A 202
TYR A 153
GLN A 178
ILE A 115
 None
 1.22A 6f6sA-1t2wA:
0.0
6f6sB-1t2wA:
0.0		 6f6sA-1t2wA:
18.79
6f6sB-1t2wA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w2l CYTOCHROME OXIDASE
SUBUNIT II

(Rhodothermus
marinus) 		PF00034
(Cytochrom_C) 		4 ALA A  10
TYR A  13
GLN A  97
ILE A  95
 None
 1.21A 6f6sA-1w2lA:
0.0
6f6sB-1w2lA:
0.0		 6f6sA-1w2lA:
17.82
6f6sB-1w2lA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yck PEPTIDOGLYCAN
RECOGNITION PROTEIN

(Homo sapiens) 		PF01510
(Amidase_2) 		4 ARG A  57
ALA A  56
TYR A  85
GLN A  54
 None
 1.15A 6f6sA-1yckA:
undetectable
6f6sB-1yckA:
0.0		 6f6sA-1yckA:
16.77
6f6sB-1yckA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a8i THREONINE ASPARTASE
1

(Homo sapiens) 		PF01112
(Asparaginase_2) 		4 ARG A  67
ALA A  68
GLN A  70
ILE A  73
 None
 1.34A 6f6sA-2a8iA:
undetectable
6f6sB-2a8iA:
0.0		 6f6sA-2a8iA:
16.19
6f6sB-2a8iA:
11.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2adv GLUTARYL 7-
AMINOCEPHALOSPORANIC
ACID ACYLASE

(Pseudomonas sp.
SY-77-1) 		PF01804
(Penicil_amidase) 		4 ARG C 329
ALA C 328
GLN C 325
ILE C 318
 None
 1.37A 6f6sA-2advC:
undetectable
6f6sB-2advC:
undetectable		 6f6sA-2advC:
11.34
6f6sB-2advC:
9.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bwp 5-AMINOLEVULINATE
SYNTHASE

(Rhodobacter
capsulatus) 		PF00155
(Aminotran_1_2) 		4 ALA A 288
TYR A 250
GLN A 289
ILE A 100
 None
 1.38A 6f6sA-2bwpA:
undetectable
6f6sB-2bwpA:
undetectable		 6f6sA-2bwpA:
10.95
6f6sB-2bwpA:
12.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ery RAS-RELATED PROTEIN
R-RAS2

(Homo sapiens) 		PF00071
(Ras) 		4 ARG A 147
ALA A 146
TYR A 153
GLN A 144
 None
 1.12A 6f6sA-2eryA:
undetectable
6f6sB-2eryA:
undetectable		 6f6sA-2eryA:
17.75
6f6sB-2eryA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2euh NADP DEPENDENT NON
PHOSPHORYLATING
GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE

(Streptococcus
mutans) 		PF00171
(Aldedh) 		4 ARG A 245
ALA A 222
TYR A  46
GLN A 221
 None
 1.37A 6f6sA-2euhA:
undetectable
6f6sB-2euhA:
undetectable		 6f6sA-2euhA:
12.01
6f6sB-2euhA:
9.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f5u VIRION PROTEIN UL25

(Human
alphaherpesvirus
1) 		PF01499
(Herpes_UL25) 		4 ARG A 494
ALA A 493
GLN A 495
ILE A 182
 None
 0.99A 6f6sA-2f5uA:
undetectable
6f6sB-2f5uA:
undetectable		 6f6sA-2f5uA:
12.06
6f6sB-2f5uA:
14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fv5 ADAM 17

(Homo sapiens) 		PF13688
(Reprolysin_5) 		4 ARG A 473
ALA A 476
GLN A 278
ILE A 279
 None
 1.35A 6f6sA-2fv5A:
undetectable
6f6sB-2fv5A:
undetectable		 6f6sA-2fv5A:
16.81
6f6sB-2fv5A:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gsj PROTEIN PPL-2

(Parkia
platycephala) 		PF00704
(Glyco_hydro_18) 		4 ARG A  94
ALA A  93
TYR A 132
GLN A  91
 None
 1.12A 6f6sA-2gsjA:
undetectable
6f6sB-2gsjA:
undetectable		 6f6sA-2gsjA:
16.33
6f6sB-2gsjA:
13.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hhz PYRIDOXAMINE
5'-PHOSPHATE
OXIDASE-RELATED

(Streptococcus
suis) 		PF01243
(Putative_PNPOx) 		4 ARG A  84
ALA A  83
GLN A 117
ILE A 138
 None
 1.33A 6f6sA-2hhzA:
undetectable
6f6sB-2hhzA:
undetectable		 6f6sA-2hhzA:
16.33
6f6sB-2hhzA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j7c BETA-GLUCOSIDASE A

(Thermotoga
maritima) 		PF00232
(Glyco_hydro_1) 		4 ALA A 377
TYR A 374
GLN A 381
ILE A 331
 None
 1.36A 6f6sA-2j7cA:
undetectable
6f6sB-2j7cA:
undetectable		 6f6sA-2j7cA:
11.63
6f6sB-2j7cA:
8.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lbc UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 13

(Homo sapiens) 		PF00627
(UBA) 		4 ARG A 100
ALA A 101
GLN A  97
ILE A 113
 None
 1.14A 6f6sA-2lbcA:
undetectable
6f6sB-2lbcA:
undetectable		 6f6sA-2lbcA:
19.08
6f6sB-2lbcA:
24.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ogs THERMOSTABLE
CARBOXYLESTERASE
EST50

(Geobacillus
stearothermophilus) 		PF00135
(COesterase) 		4 ALA A 383
TYR A 467
GLN A 382
ILE A 304
 ALA  A 383 ( 0.0A)
TYR  A 467 ( 1.3A)
GLN  A 382 ( 0.6A)
ILE  A 304 ( 0.7A)
 1.39A 6f6sA-2ogsA:
undetectable
6f6sB-2ogsA:
undetectable		 6f6sA-2ogsA:
10.41
6f6sB-2ogsA:
11.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2on5 NA GLUTATHIONE
S-TRANSFERASE 2

(Necator
americanus) 		PF02798
(GST_N)
PF14497
(GST_C_3) 		4 ALA A  23
TYR A  29
GLN A  20
ILE A  18
 None
EDO  A 427 (-3.6A)
None
EDO  A 425 (-4.7A)
 1.21A 6f6sA-2on5A:
undetectable
6f6sB-2on5A:
undetectable		 6f6sA-2on5A:
18.92
6f6sB-2on5A:
15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2puz IMIDAZOLONEPROPIONAS
E

(Agrobacterium
fabrum) 		PF01979
(Amidohydro_1) 		4 ARG A 249
ALA A 216
TYR A 187
ILE A 162
 None
 1.15A 6f6sA-2puzA:
undetectable
6f6sB-2puzA:
undetectable		 6f6sA-2puzA:
15.04
6f6sB-2puzA:
11.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qjx PROTEIN BIM1

(Saccharomyces
cerevisiae) 		no annotation 4 ARG A 121
ALA A  34
GLN A  38
ILE A  39
 None
 1.18A 6f6sA-2qjxA:
undetectable
6f6sB-2qjxA:
undetectable		 6f6sA-2qjxA:
18.10
6f6sB-2qjxA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r3b YJEF-RELATED PROTEIN

(Enterococcus
faecalis) 		PF01256
(Carb_kinase) 		4 ARG A 175
ALA A 178
GLN A 176
ILE A 184
 None
 1.19A 6f6sA-2r3bA:
undetectable
6f6sB-2r3bA:
undetectable		 6f6sA-2r3bA:
15.77
6f6sB-2r3bA:
14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vow SURFACE-ASSOCIATED
PROTEIN

(Methylococcus
capsulatus) 		no annotation 4 ALA A 209
TYR A 244
GLN A 207
ILE A 168
 None
 1.36A 6f6sA-2vowA:
undetectable
6f6sB-2vowA:
undetectable		 6f6sA-2vowA:
13.94
6f6sB-2vowA:
13.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wac CG7008-PA

(Drosophila
melanogaster) 		PF00567
(TUDOR) 		4 ARG A 796
ALA A 758
TYR A 767
GLN A 759
 None
 1.24A 6f6sA-2wacA:
undetectable
6f6sB-2wacA:
undetectable		 6f6sA-2wacA:
15.82
6f6sB-2wacA:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wbn TERMINASE LARGE
SUBUNIT

(Bacillus phage
SPP1) 		PF17288
(Terminase_3C) 		4 ALA A 362
TYR A 289
GLN A 244
ILE A 249
 None
 1.40A 6f6sA-2wbnA:
undetectable
6f6sB-2wbnA:
undetectable		 6f6sA-2wbnA:
17.06
6f6sB-2wbnA:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x2i ALPHA-1,4-GLUCAN
LYASE ISOZYME 1

(Gracilariopsis
lemaneiformis) 		PF01055
(Glyco_hydro_31) 		4 ARG A 717
ALA A 721
GLN A 720
ILE A 874
 None
 1.24A 6f6sA-2x2iA:
undetectable
6f6sB-2x2iA:
undetectable		 6f6sA-2x2iA:
5.26
6f6sB-2x2iA:
5.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xfx MHC CLASS 1

(Bos taurus) 		PF00129
(MHC_I)
PF07654
(C1-set) 		4 ALA A 135
TYR A 123
GLN A 141
ILE A 142
 None
 1.39A 6f6sA-2xfxA:
undetectable
6f6sB-2xfxA:
undetectable		 6f6sA-2xfxA:
15.88
6f6sB-2xfxA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ayh DNA-DIRECTED RNA
POLYMERASE III
SUBUNIT RPC8

(Schizosaccharomyces
pombe) 		PF03876
(SHS2_Rpb7-N)
PF08292
(RNA_pol_Rbc25) 		4 ARG B 125
ALA B 126
TYR B 143
ILE B  89
 None
 1.37A 6f6sA-3ayhB:
undetectable
6f6sB-3ayhB:
undetectable		 6f6sA-3ayhB:
16.83
6f6sB-3ayhB:
16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bze HLA CLASS I
HISTOCOMPATIBILITY
ANTIGEN, ALPHA CHAIN
E

(Homo sapiens) 		PF00129
(MHC_I)
PF07654
(C1-set) 		4 ALA A 135
TYR A 123
GLN A 141
ILE A 142
 None
 1.27A 6f6sA-3bzeA:
undetectable
6f6sB-3bzeA:
undetectable		 6f6sA-3bzeA:
14.72
6f6sB-3bzeA:
13.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cze SUCROSE HYDROLASE

(Xanthomonas
citri) 		PF00128
(Alpha-amylase) 		4 ARG A 192
ALA A 191
TYR A 202
GLN A 189
 None
 1.30A 6f6sA-3czeA:
undetectable
6f6sB-3czeA:
undetectable		 6f6sA-3czeA:
9.26
6f6sB-3czeA:
8.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3go5 MULTIDOMAIN PROTEIN
WITH S1 RNA-BINDING
DOMAINS

(Streptococcus
pneumoniae) 		PF13509
(S1_2) 		4 ARG A 120
ALA A 134
TYR A 135
ILE A 102
 None
 0.98A 6f6sA-3go5A:
undetectable
6f6sB-3go5A:
undetectable		 6f6sA-3go5A:
15.56
6f6sB-3go5A:
14.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h0g DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB1

(Schizosaccharomyces
pombe) 		PF00623
(RNA_pol_Rpb1_2)
PF04983
(RNA_pol_Rpb1_3)
PF04990
(RNA_pol_Rpb1_7)
PF04992
(RNA_pol_Rpb1_6)
PF04997
(RNA_pol_Rpb1_1)
PF04998
(RNA_pol_Rpb1_5)
PF05000
(RNA_pol_Rpb1_4) 		4 ARG A 538
ALA A 535
GLN A 751
ILE A 670
 None
 1.40A 6f6sA-3h0gA:
undetectable
6f6sB-3h0gA:
undetectable		 6f6sA-3h0gA:
4.66
6f6sB-3h0gA:
4.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3if2 AMINOTRANSFERASE

(Psychrobacter
arcticus) 		PF00155
(Aminotran_1_2) 		4 ALA A 340
TYR A 256
GLN A 339
ILE A 365
 None
 1.37A 6f6sA-3if2A:
undetectable
6f6sB-3if2A:
undetectable		 6f6sA-3if2A:
9.71
6f6sB-3if2A:
12.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jrk TAGATOSE
1,6-DIPHOSPHATE
ALDOLASE 2

(Streptococcus
pyogenes) 		PF01791
(DeoC) 		4 ARG A 293
ALA A 292
TYR A 284
GLN A 290
 None
 1.18A 6f6sA-3jrkA:
undetectable
6f6sB-3jrkA:
undetectable		 6f6sA-3jrkA:
15.79
6f6sB-3jrkA:
12.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k44 PURINE-RICH BINDING
PROTEIN-ALPHA,
ISOFORM B

(Drosophila
melanogaster) 		PF04845
(PurA) 		4 ARG A 147
ALA A 162
GLN A 160
ILE A  83
 None
 1.28A 6f6sA-3k44A:
undetectable
6f6sB-3k44A:
0.0		 6f6sA-3k44A:
21.38
6f6sB-3k44A:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kyo MHC CLASS I ANTIGEN

(Homo sapiens) 		PF00129
(MHC_I)
PF07654
(C1-set) 		4 ALA A 135
TYR A 123
GLN A 141
ILE A 142
 None
 1.32A 6f6sA-3kyoA:
undetectable
6f6sB-3kyoA:
undetectable		 6f6sA-3kyoA:
16.67
6f6sB-3kyoA:
13.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m1p RIBOSE 5-PHOSPHATE
ISOMERASE

(Trypanosoma
cruzi) 		PF02502
(LacAB_rpiB) 		4 ARG A 113
ALA A  69
TYR A  46
ILE A  73
 None
 1.31A 6f6sA-3m1pA:
undetectable
6f6sB-3m1pA:
undetectable		 6f6sA-3m1pA:
19.35
6f6sB-3m1pA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n08 PUTATIVE
PHOSPHATIDYLETHANOLA
MINE-BINDING PROTEIN
(PEBP)

(Chlamydia
trachomatis) 		PF01161
(PBP) 		4 ALA A  83
TYR A  66
GLN A  85
ILE A  64
 None
 1.32A 6f6sA-3n08A:
undetectable
6f6sB-3n08A:
undetectable		 6f6sA-3n08A:
23.97
6f6sB-3n08A:
24.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oaa ATP SYNTHASE SUBUNIT
BETA

(Escherichia
coli) 		PF00006
(ATP-synt_ab)
PF02874
(ATP-synt_ab_N) 		4 ARG D 394
TYR D 444
GLN D 397
ILE D 330
 None
 1.39A 6f6sA-3oaaD:
undetectable
6f6sB-3oaaD:
0.0		 6f6sA-3oaaD:
10.26
6f6sB-3oaaD:
10.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p9c CAFFEIC ACID
O-METHYLTRANSFERASE

(Lolium perenne) 		PF00891
(Methyltransf_2)
PF08100
(Dimerisation) 		4 ARG A 337
ALA A 336
GLN A 333
ILE A 356
 None
 1.32A 6f6sA-3p9cA:
undetectable
6f6sB-3p9cA:
undetectable		 6f6sA-3p9cA:
13.26
6f6sB-3p9cA:
13.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qfw RIBULOSE-1,5-BISPHOS
PHATE
CARBOXYLASE/OXYGENAS
E LARGE SUBUNIT

(Rhodopseudomonas
palustris) 		PF00016
(RuBisCO_large) 		4 ARG A 214
ALA A 178
GLN A 215
ILE A 219
 None
 1.40A 6f6sA-3qfwA:
undetectable
6f6sB-3qfwA:
undetectable		 6f6sA-3qfwA:
11.29
6f6sB-3qfwA:
13.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qj4 RENALASE

(Homo sapiens) 		PF01593
(Amino_oxidase)
PF13450
(NAD_binding_8) 		4 ARG A  22
ALA A  18
TYR A 118
ILE A 328
 None
 1.12A 6f6sA-3qj4A:
undetectable
6f6sB-3qj4A:
undetectable		 6f6sA-3qj4A:
12.61
6f6sB-3qj4A:
14.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rnq PROGRAMMED CELL
DEATH 1 LIGAND 2

(Mus musculus) 		PF08205
(C2-set_2) 		4 ARG B 146
ALA B 145
TYR B 123
GLN B 175
 None
 1.27A 6f6sA-3rnqB:
undetectable
6f6sB-3rnqB:
undetectable		 6f6sA-3rnqB:
18.13
6f6sB-3rnqB:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ruc WBGU

(Plesiomonas
shigelloides) 		PF01370
(Epimerase) 		4 ARG A 192
ALA A 141
TYR A 139
ILE A 189
 None
 1.25A 6f6sA-3rucA:
0.3
6f6sB-3rucA:
undetectable		 6f6sA-3rucA:
14.84
6f6sB-3rucA:
11.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3skv SSFX3

(Streptomyces
sp. SF2575) 		PF13472
(Lipase_GDSL_2) 		4 ARG A  41
ALA A  42
GLN A 201
ILE A 220
 None
 1.35A 6f6sA-3skvA:
undetectable
6f6sB-3skvA:
undetectable		 6f6sA-3skvA:
11.35
6f6sB-3skvA:
10.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tsc PUTATIVE
OXIDOREDUCTASE

(Mycobacterium
avium) 		PF13561
(adh_short_C2) 		4 ARG A 182
ALA A 181
GLN A 263
ILE A 264
 None
 1.28A 6f6sA-3tscA:
undetectable
6f6sB-3tscA:
undetectable		 6f6sA-3tscA:
18.22
6f6sB-3tscA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vj6 H-2 CLASS I
HISTOCOMPATIBILITY
ANTIGEN, D-37 ALPHA
CHAIN

(Mus musculus) 		PF00129
(MHC_I)
PF07654
(C1-set) 		4 ALA A 135
TYR A 123
GLN A 141
ILE A 142
 None
 1.27A 6f6sA-3vj6A:
undetectable
6f6sB-3vj6A:
0.0		 6f6sA-3vj6A:
14.80
6f6sB-3vj6A:
14.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vtx MAMA

(Candidatus
Magnetobacterium
bavaricum) 		PF00515
(TPR_1)
PF13174
(TPR_6)
PF13181
(TPR_8)
PF13414
(TPR_11) 		4 ARG A 181
ALA A 182
TYR A 169
GLN A 184
 None
 1.27A 6f6sA-3vtxA:
undetectable
6f6sB-3vtxA:
undetectable		 6f6sA-3vtxA:
19.30
6f6sB-3vtxA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w3a V-TYPE ATP SYNTHASE
BETA CHAIN

(Thermus
thermophilus) 		PF00006
(ATP-synt_ab)
PF02874
(ATP-synt_ab_N) 		4 ARG D 169
ALA D 165
TYR D 203
GLN D 166
 None
 1.22A 6f6sA-3w3aD:
undetectable
6f6sB-3w3aD:
undetectable		 6f6sA-3w3aD:
13.22
6f6sB-3w3aD:
11.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c60 OCHRATOXINASE

(Aspergillus
niger) 		PF01979
(Amidohydro_1) 		4 ARG A 330
ALA A 328
TYR A 326
ILE A 367
 None
 1.37A 6f6sA-4c60A:
undetectable
6f6sB-4c60A:
undetectable		 6f6sA-4c60A:
10.80
6f6sB-4c60A:
11.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ghn UNCHARACTERIZED
PROTEIN

(Bacteroides
uniformis) 		PF03572
(Peptidase_S41) 		4 ARG A  90
ALA A  94
TYR A 100
ILE A  45
 GOL  A 501 (-3.8A)
None
None
None
 1.18A 6f6sA-4ghnA:
undetectable
6f6sB-4ghnA:
undetectable		 6f6sA-4ghnA:
12.91
6f6sB-4ghnA:
12.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hb9 SIMILARITIES WITH
PROBABLE
MONOOXYGENASE

(Photorhabdus
laumondii) 		PF01494
(FAD_binding_3) 		4 ARG A 366
ALA A 367
TYR A 368
GLN A 363
 None
 1.17A 6f6sA-4hb9A:
undetectable
6f6sB-4hb9A:
undetectable		 6f6sA-4hb9A:
12.27
6f6sB-4hb9A:
12.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hbs PUTATIVE HYDROLASE

(Bacteroides
ovatus) 		PF16396
(DUF5005) 		4 ARG A 268
ALA A 267
TYR A 257
ILE A 306
 None
 1.32A 6f6sA-4hbsA:
undetectable
6f6sB-4hbsA:
undetectable		 6f6sA-4hbsA:
12.53
6f6sB-4hbsA:
12.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i6m ACTIN-LIKE PROTEIN
ARP9

(Saccharomyces
cerevisiae) 		PF00022
(Actin)
PF07529
(HSA) 		4 ARG C 632
ALA C 635
GLN B 438
ILE B 434
 None
 1.38A 6f6sA-4i6mC:
undetectable
6f6sB-4i6mC:
undetectable		 6f6sA-4i6mC:
23.01
6f6sB-4i6mC:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ib2 PUTATIVE LIPOPROTEIN

([Ruminococcus]
gnavus) 		PF03180
(Lipoprotein_9) 		4 ARG A 194
ALA A 193
TYR A 208
GLN A 191
 None
None
CL  A 301 (-4.6A)
None
 1.36A 6f6sA-4ib2A:
undetectable
6f6sB-4ib2A:
undetectable		 6f6sA-4ib2A:
18.06
6f6sB-4ib2A:
16.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j8f HEAT SHOCK 70 KDA
PROTEIN 1A/1B,
HSC70-INTERACTING
PROTEIN

(Homo sapiens;
Rattus
norvegicus) 		PF00012
(HSP70) 		4 ARG A 475
ALA A 473
GLN A 403
ILE A 440
 None
 1.39A 6f6sA-4j8fA:
undetectable
6f6sB-4j8fA:
undetectable		 6f6sA-4j8fA:
12.21
6f6sB-4j8fA:
9.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lcy HLA CLASS I
HISTOCOMPATIBILITY
ANTIGEN, B-46 ALPHA
CHAIN

(Homo sapiens) 		PF00129
(MHC_I)
PF07654
(C1-set) 		4 ALA A 135
TYR A 123
GLN A 141
ILE A 142
 None
 1.36A 6f6sA-4lcyA:
undetectable
6f6sB-4lcyA:
0.0		 6f6sA-4lcyA:
15.85
6f6sB-4lcyA:
15.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ldy AUXIN RESPONSE
FACTOR 1

(Arabidopsis
thaliana) 		PF02362
(B3)
PF06507
(Auxin_resp) 		4 ARG A  82
ALA A  93
TYR A 264
ILE A 274
 None
 1.35A 6f6sA-4ldyA:
undetectable
6f6sB-4ldyA:
undetectable		 6f6sA-4ldyA:
15.60
6f6sB-4ldyA:
12.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mjz OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE

(Toxoplasma
gondii) 		PF00215
(OMPdecase) 		4 ARG A 198
ALA A 197
TYR A 193
GLN A 195
 None
 1.14A 6f6sA-4mjzA:
undetectable
6f6sB-4mjzA:
undetectable		 6f6sA-4mjzA:
14.29
6f6sB-4mjzA:
13.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mzl MYOSIN A TAIL DOMAIN
INTERACTING PROTEIN

(Plasmodium
falciparum) 		no annotation 4 ARG A 100
ALA A  99
TYR A 130
ILE A  90
 None
 1.36A 6f6sA-4mzlA:
undetectable
6f6sB-4mzlA:
undetectable		 6f6sA-4mzlA:
17.69
6f6sB-4mzlA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nfd PAIRED
IMMUNOGLOBULIN-LIKE
TYPE 2 RECEPTOR BETA

(Homo sapiens) 		PF07686
(V-set) 		4 ARG A  96
TYR A   3
GLN A 110
ILE A 112
 SIA  A 201 (-3.0A)
SIA  A 201 (-3.4A)
None
None
 1.25A 6f6sA-4nfdA:
undetectable
6f6sB-4nfdA:
undetectable		 6f6sA-4nfdA:
20.83
6f6sB-4nfdA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pev MEMBRANE LIPOPROTEIN
FAMILY PROTEIN

(Aeropyrum
pernix) 		PF02608
(Bmp) 		4 ALA A 188
TYR A 230
GLN A 306
ILE A 304
 None
 1.25A 6f6sA-4pevA:
undetectable
6f6sB-4pevA:
undetectable		 6f6sA-4pevA:
12.53
6f6sB-4pevA:
11.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pqg GLYCOSYLTRANSFERASE
GTF1

(Streptococcus
pneumoniae) 		PF00534
(Glycos_transf_1) 		4 ARG A  24
ALA A  25
GLN A  21
ILE A  55
 None
 1.33A 6f6sA-4pqgA:
undetectable
6f6sB-4pqgA:
undetectable		 6f6sA-4pqgA:
10.92
6f6sB-4pqgA:
9.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rkz PUTATIVE
UNCHARACTERIZED
PROTEIN TA1305

(Thermoplasma
acidophilum) 		no annotation 4 ARG A 144
ALA A  38
TYR A  39
ILE A 176
 3S4  A 402 (-2.8A)
None
None
None
 1.33A 6f6sA-4rkzA:
undetectable
6f6sB-4rkzA:
0.0		 6f6sA-4rkzA:
14.06
6f6sB-4rkzA:
12.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zlg PUTATIVE B-GLYCAN
PHOSPHORYLASE

(Saccharophagus
degradans) 		PF06165
(Glyco_transf_36)
PF17167
(Glyco_hydro_36) 		4 ALA A 234
TYR A 157
GLN A 236
ILE A  90
 None
 1.21A 6f6sA-4zlgA:
undetectable
6f6sB-4zlgA:
0.0		 6f6sA-4zlgA:
8.36
6f6sB-4zlgA:
7.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zwo ORGANOPHOSPHATE
ANHYDROLASE/PROLIDAS
E

(Alteromonas sp.) 		PF00557
(Peptidase_M24) 		4 ALA A 202
TYR A 199
GLN A 177
ILE A 174
 None
 1.15A 6f6sA-4zwoA:
undetectable
6f6sB-4zwoA:
undetectable		 6f6sA-4zwoA:
11.35
6f6sB-4zwoA:
11.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zxo GLYCOSYL HYDROLASE
FAMILY 26

(Bacteroides
ovatus) 		PF02156
(Glyco_hydro_26) 		4 ARG A 116
ALA A 115
GLN A 113
ILE A 110
 None
 1.20A 6f6sA-4zxoA:
undetectable
6f6sB-4zxoA:
undetectable		 6f6sA-4zxoA:
13.24
6f6sB-4zxoA:
12.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c2v HYDRAZINE SYNTHASE
ALPHA SUBUNIT

(Candidatus
Kuenenia
stuttgartiensis) 		no annotation 4 ALA A 488
TYR A 535
GLN A 536
ILE A 491
 None
 1.40A 6f6sA-5c2vA:
undetectable
6f6sB-5c2vA:
undetectable		 6f6sA-5c2vA:
7.54
6f6sB-5c2vA:
6.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cxu FERULIC ACID
ESTERASE AMCE1/FAE1A

(Anaeromyces
mucronatus) 		PF00756
(Esterase) 		4 ARG A  90
ALA A  91
GLN A 267
ILE A  81
 None
 1.27A 6f6sA-5cxuA:
undetectable
6f6sB-5cxuA:
undetectable		 6f6sA-5cxuA:
15.55
6f6sB-5cxuA:
14.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d9a RNA-DIRECTED RNA
POLYMERASE CATALYTIC
SUBUNIT

(Influenza C
virus) 		PF00602
(Flu_PB1) 		4 ARG B 557
ALA B 558
GLN B 554
ILE B 551
 None
 1.25A 6f6sA-5d9aB:
undetectable
6f6sB-5d9aB:
undetectable		 6f6sA-5d9aB:
7.83
6f6sB-5d9aB:
7.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5drz HIV ANTIBODY F240
LIGHT CHAIN

(Homo sapiens) 		no annotation 4 ARG L  39
ALA L  83
GLN L  37
ILE L  75
 None
MG  L 301 (-3.3A)
None
None
 1.35A 6f6sA-5drzL:
undetectable
6f6sB-5drzL:
undetectable		 6f6sA-5drzL:
15.00
6f6sB-5drzL:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e9u GLYCOSYLTRANSFERASE
GTF1

(Streptococcus
gordonii) 		PF00534
(Glycos_transf_1) 		4 ARG A  24
ALA A  25
GLN A  21
ILE A  55
 None
 1.40A 6f6sA-5e9uA:
undetectable
6f6sB-5e9uA:
undetectable		 6f6sA-5e9uA:
8.95
6f6sB-5e9uA:
11.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f1n MHC CLASS I ANTIGEN

(Canis lupus) 		PF00129
(MHC_I)
PF07654
(C1-set) 		4 ALA A 135
TYR A 123
GLN A 141
ILE A 142
 None
 1.39A 6f6sA-5f1nA:
undetectable
6f6sB-5f1nA:
undetectable		 6f6sA-5f1nA:
16.54
6f6sB-5f1nA:
15.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f7o METHYLTHIOADENOSINE
PHOSPHORYLASE

(Schistosoma
mansoni) 		PF01048
(PNP_UDP_1) 		4 ARG A 151
ALA A 150
GLN A 148
ILE A 145
 None
 1.08A 6f6sA-5f7oA:
undetectable
6f6sB-5f7oA:
undetectable		 6f6sA-5f7oA:
14.57
6f6sB-5f7oA:
12.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h64 SERINE/THREONINE-PRO
TEIN KINASE MTOR

(Homo sapiens) 		PF00454
(PI3_PI4_kinase)
PF02259
(FAT)
PF02260
(FATC)
PF08771
(FRB_dom)
PF11865
(DUF3385) 		4 ALA A1462
TYR A1463
GLN A1446
ILE A1445
 None
 1.13A 6f6sA-5h64A:
undetectable
6f6sB-5h64A:
undetectable		 6f6sA-5h64A:
2.80
6f6sB-5h64A:
3.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h7d PUTRESCINE
AMINOTRANSFERASE,IMM
UNOGLOBULIN
G-BINDING PROTEIN A

(Escherichia
coli;
Staphylococcus
aureus) 		PF00202
(Aminotran_3)
PF02216
(B) 		4 ARG A 375
ALA A 374
GLN A 372
ILE A 442
 None
 1.09A 6f6sA-5h7dA:
undetectable
6f6sB-5h7dA:
undetectable		 6f6sA-5h7dA:
10.71
6f6sB-5h7dA:
12.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hdi CYTOCHROME P450 144

(Mycobacterium
tuberculosis) 		PF00067
(p450) 		4 ARG A 238
ALA A 239
GLN A 235
ILE A 232
 None
 1.22A 6f6sA-5hdiA:
undetectable
6f6sB-5hdiA:
undetectable		 6f6sA-5hdiA:
11.14
6f6sB-5hdiA:
14.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5idi 1,4-BETA-D-GLUCAN
GLUCOHYDROLASE

(Thermotoga
neapolitana) 		PF00232
(Glyco_hydro_1) 		4 ALA A 375
TYR A 372
GLN A 379
ILE A 329
 None
 1.35A 6f6sA-5idiA:
undetectable
6f6sB-5idiA:
undetectable		 6f6sA-5idiA:
10.93
6f6sB-5idiA:
11.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ip9 DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB2

(Saccharomyces
cerevisiae) 		PF00562
(RNA_pol_Rpb2_6)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF04566
(RNA_pol_Rpb2_4)
PF04567
(RNA_pol_Rpb2_5) 		4 ARG B 118
ALA B 117
TYR B 124
GLN B 115
 None
 1.19A 6f6sA-5ip9B:
undetectable
6f6sB-5ip9B:
undetectable		 6f6sA-5ip9B:
5.63
6f6sB-5ip9B:
5.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ixx ALR2278 PROTEIN

(Nostoc sp. PCC
7120) 		PF07700
(HNOB) 		4 ALA A   8
TYR A  73
GLN A  10
ILE A  13
 None
 1.18A 6f6sA-5ixxA:
undetectable
6f6sB-5ixxA:
undetectable		 6f6sA-5ixxA:
15.34
6f6sB-5ixxA:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kbp GLYCOSYL HYDROLASE,
FAMILY 38

(Enterococcus
faecalis) 		PF01074
(Glyco_hydro_38)
PF07748
(Glyco_hydro_38C)
PF09261
(Alpha-mann_mid) 		4 ALA A 793
TYR A 411
GLN A 797
ILE A 798
 None
 1.36A 6f6sA-5kbpA:
undetectable
6f6sB-5kbpA:
undetectable		 6f6sA-5kbpA:
6.90
6f6sB-5kbpA:
6.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m9n TUDOR
DOMAIN-CONTAINING
PROTEIN 1

(Homo sapiens) 		PF00567
(TUDOR) 		4 ARG A 588
ALA A 549
TYR A 558
GLN A 550
 None
 1.20A 6f6sA-5m9nA:
undetectable
6f6sB-5m9nA:
undetectable		 6f6sA-5m9nA:
16.36
6f6sB-5m9nA:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nb3 PHYCOERYTHRIN ALPHA
SUBUNIT,PHYCOERYTHRI
N ALPHA
SUBUNIT,PHYCOERYTHRI
N ALPHA SUBUNIT

(Phormidium
rubidum) 		PF00502
(Phycobilisome) 		4 ALA A  40
TYR A 152
GLN A  94
ILE A  93
 None
PEB  A 167 ( 4.4A)
None
None
 1.26A 6f6sA-5nb3A:
undetectable
6f6sB-5nb3A:
undetectable		 6f6sA-5nb3A:
23.53
6f6sB-5nb3A:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nci LEUCINE HYDROXYLASE

(Streptomyces
muensis) 		PF05721
(PhyH) 		4 ARG A  56
ALA A  57
TYR A  59
ILE A 225
 None
None
LEU  A 303 (-4.6A)
None
 1.23A 6f6sA-5nciA:
undetectable
6f6sB-5nciA:
undetectable		 6f6sA-5nciA:
14.96
6f6sB-5nciA:
15.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nd5 TRANSKETOLASE

(Chlamydomonas
reinhardtii) 		PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		4 ALA A 694
TYR A 698
GLN A 527
ILE A 685
 None
 1.32A 6f6sA-5nd5A:
undetectable
6f6sB-5nd5A:
undetectable		 6f6sA-5nd5A:
8.42
6f6sB-5nd5A:
8.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ngv ANTI-HUMAN ACTRIIB
MAB BYM338
HEAVY-CHAIN

(Homo sapiens) 		no annotation 4 ARG H  72
ALA H  79
TYR H  80
ILE H  76
 None
 1.38A 6f6sA-5ngvH:
undetectable
6f6sB-5ngvH:
undetectable		 6f6sA-5ngvH:
18.18
6f6sB-5ngvH:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nm7 PEPTIDOGLYCAN-BINDIN
G DOMAIN 1

(Burkholderia) 		no annotation 4 ALA G 202
TYR G 193
GLN G 210
ILE G 183
 None
 1.38A 6f6sA-5nm7G:
undetectable
6f6sB-5nm7G:
undetectable		 6f6sA-5nm7G:
25.77
6f6sB-5nm7G:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xn6 OS07G0580900 PROTEIN

(Oryza sativa) 		PF00348
(polyprenyl_synt) 		4 ARG A 279
ALA A 278
TYR A 219
ILE A 300
 None
 1.23A 6f6sA-5xn6A:
undetectable
6f6sB-5xn6A:
undetectable		 6f6sA-5xn6A:
14.43
6f6sB-5xn6A:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xog DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA

(Komagataella
phaffii) 		PF00562
(RNA_pol_Rpb2_6)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF04566
(RNA_pol_Rpb2_4)
PF04567
(RNA_pol_Rpb2_5) 		4 ARG B 105
ALA B 104
TYR B 111
GLN B 102
 None
 1.27A 6f6sA-5xogB:
undetectable
6f6sB-5xogB:
undetectable		 6f6sA-5xogB:
5.73
6f6sB-5xogB:
6.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yrp SENSORY BOX/RESPONSE
REGULATOR

(Mycolicibacterium
smegmatis) 		no annotation 4 ARG A 442
ALA A 383
GLN A 583
ILE A 373
 None
 1.30A 6f6sA-5yrpA:
undetectable
6f6sB-5yrpA:
undetectable		 6f6sA-5yrpA:
22.62
6f6sB-5yrpA:
25.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yv5 ATPASE RIL

(Pyrococcus
furiosus) 		no annotation 4 ARG A 255
ALA A 250
TYR A 275
ILE A 554
 None
 1.39A 6f6sA-5yv5A:
undetectable
6f6sB-5yv5A:
undetectable		 6f6sA-5yv5A:
undetectable
6f6sB-5yv5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6avf HLA CLASS I
HISTOCOMPATIBILITY
ANTIGEN, B-7 ALPHA
CHAIN

(Homo sapiens) 		no annotation 4 ALA H 135
TYR H 123
GLN H 141
ILE H 142
 None
 1.30A 6f6sA-6avfH:
undetectable
6f6sB-6avfH:
0.0		 6f6sA-6avfH:
20.00
6f6sB-6avfH:
15.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c6l V-TYPE PROTON ATPASE
SUBUNIT A, VACUOLAR
ISOFORM

(Saccharomyces
cerevisiae) 		no annotation 4 ARG A 382
ALA A  12
TYR A 817
ILE A 341
 None
 1.35A 6f6sA-6c6lA:
undetectable
6f6sB-6c6lA:
0.0		 6f6sA-6c6lA:
11.25
6f6sB-6c6lA:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cud SHORT TRANSIENT
RECEPTOR POTENTIAL
CHANNEL 3

(Homo sapiens) 		no annotation 4 ARG A 475
ALA A 471
TYR A 530
ILE A 429
 None
 1.36A 6f6sA-6cudA:
undetectable
6f6sB-6cudA:
undetectable		 6f6sA-6cudA:
23.16
6f6sB-6cudA:
21.43