SIMILAR PATTERNS OF AMINO ACIDS FOR 6F6N_A_SREA508_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fnn CELL DIVISION
CONTROL PROTEIN 6

(Pyrobaculum
aerophilum) 		PF09079
(Cdc6_C)
PF13401
(AAA_22) 		5 ARG A 267
LEU A 375
LEU A 372
LEU A 294
LEU A 293
 None
 0.93A 6f6nA-1fnnA:
0.0
6f6nB-1fnnA:
undetectable		 6f6nA-1fnnA:
12.88
6f6nB-1fnnA:
13.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gk2 HISTIDINE
AMMONIA-LYASE

(Pseudomonas
putida) 		PF00221
(Lyase_aromatic) 		6 VAL A 118
ALA A 121
LEU A 185
LEU A 157
LEU A 194
LEU A 193
 None
 1.43A 6f6nA-1gk2A:
0.0
6f6nB-1gk2A:
0.0		 6f6nA-1gk2A:
10.88
6f6nB-1gk2A:
10.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jx2 MYOSIN-2 HEAVY
CHAIN,DYNAMIN-A

(Dictyostelium
discoideum) 		PF00063
(Myosin_head)
PF02736
(Myosin_N) 		5 ILE A1075
VAL A1086
LEU A1082
LEU A 809
LEU A 780
 None
 1.02A 6f6nA-1jx2A:
0.0
6f6nB-1jx2A:
0.0		 6f6nA-1jx2A:
5.89
6f6nB-1jx2A:
5.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l7v VITAMIN B12
TRANSPORT
ATP-BINDING PROTEIN
BTUD

(Escherichia
coli) 		PF00005
(ABC_tran) 		5 ILE C  28
VAL C 140
LEU C 155
LEU C 179
LEU C 157
 None
 0.97A 6f6nA-1l7vC:
undetectable
6f6nB-1l7vC:
0.0		 6f6nA-1l7vC:
16.96
6f6nB-1l7vC:
15.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mpt M-PROTEASE

(Bacillus
clausii) 		PF00082
(Peptidase_S8) 		5 VAL A 149
ALA A 174
LEU A 126
TYR A 171
LEU A 111
 None
CA  A 277 (-4.8A)
None
None
None
 0.99A 6f6nA-1mptA:
0.0
6f6nB-1mptA:
0.2		 6f6nA-1mptA:
16.06
6f6nB-1mptA:
15.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ns5 HYPOTHETICAL PROTEIN
YBEA

(Escherichia
coli) 		PF02590
(SPOUT_MTase) 		5 ILE A  69
VAL A 136
ALA A 137
LEU A 101
LEU A  72
 None
 0.94A 6f6nA-1ns5A:
undetectable
6f6nB-1ns5A:
undetectable		 6f6nA-1ns5A:
18.79
6f6nB-1ns5A:
25.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1odo PUTATIVE CYTOCHROME
P450 154A1

(Streptomyces
coelicolor) 		PF00067
(p450) 		5 VAL A  33
ALA A  40
LEU A  10
LEU A 393
LEU A  24
 None
 0.94A 6f6nA-1odoA:
undetectable
6f6nB-1odoA:
0.0		 6f6nA-1odoA:
10.29
6f6nB-1odoA:
14.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1odo PUTATIVE CYTOCHROME
P450 154A1

(Streptomyces
coelicolor) 		PF00067
(p450) 		5 VAL A 403
LEU A 378
LEU A 371
LEU A 258
LEU A 259
 None
 1.01A 6f6nA-1odoA:
undetectable
6f6nB-1odoA:
0.0		 6f6nA-1odoA:
10.29
6f6nB-1odoA:
14.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r4v HYPOTHETICAL PROTEIN
AQ_328

(Aquifex
aeolicus) 		PF09123
(DUF1931) 		5 ILE A  42
VAL A  56
ALA A  59
LEU A  52
LEU A 139
 None
 0.99A 6f6nA-1r4vA:
undetectable
6f6nB-1r4vA:
undetectable		 6f6nA-1r4vA:
19.28
6f6nB-1r4vA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vhk HYPOTHETICAL PROTEIN
YQEU

(Bacillus
subtilis) 		PF04452
(Methyltrans_RNA) 		5 VAL A 202
ALA A  84
LEU A 217
LEU A 161
LEU A 209
 None
 1.01A 6f6nA-1vhkA:
undetectable
6f6nB-1vhkA:
undetectable		 6f6nA-1vhkA:
18.75
6f6nB-1vhkA:
17.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vrm HYPOTHETICAL PROTEIN
TM1553

(Thermotoga
maritima) 		PF02424
(ApbE) 		5 ILE A 340
VAL A 320
LEU A 335
LEU A 332
LEU A 331
 None
 1.02A 6f6nA-1vrmA:
0.0
6f6nB-1vrmA:
0.0		 6f6nA-1vrmA:
13.67
6f6nB-1vrmA:
14.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wyt GLYCINE
DEHYDROGENASE
(DECARBOXYLATING)
SUBUNIT 1

(Thermus
thermophilus) 		PF02347
(GDC-P) 		5 VAL A 389
LEU A 433
LEU A 429
LEU A 380
LEU A 382
 None
 1.02A 6f6nA-1wytA:
undetectable
6f6nB-1wytA:
0.0		 6f6nA-1wytA:
15.88
6f6nB-1wytA:
12.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x0m AMINOTRANSFERASE II
HOMOLOGUE

(Pyrococcus
horikoshii) 		PF00155
(Aminotran_1_2) 		5 ILE A 359
VAL A 381
ALA A 376
LEU A  61
LEU A 340
 None
 0.96A 6f6nA-1x0mA:
undetectable
6f6nB-1x0mA:
undetectable		 6f6nA-1x0mA:
11.68
6f6nB-1x0mA:
11.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yzx GLUTATHIONE
S-TRANSFERASE KAPPA
1

(Homo sapiens) 		PF01323
(DSBA) 		5 ILE A  32
ARG A   6
VAL A   8
ALA A 188
LEU A  26
 None
 0.88A 6f6nA-1yzxA:
undetectable
6f6nB-1yzxA:
undetectable		 6f6nA-1yzxA:
17.94
6f6nB-1yzxA:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bk9 CG9734-PA

(Drosophila
melanogaster) 		PF00042
(Globin) 		5 ARG A  45
VAL A  47
LEU A  39
LEU A  28
LEU A  52
 None
 1.03A 6f6nA-2bk9A:
undetectable
6f6nB-2bk9A:
undetectable		 6f6nA-2bk9A:
19.59
6f6nB-2bk9A:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d9j REGULATOR OF
G-PROTEIN SIGNALLING
7

(Homo sapiens) 		PF00615
(RGS) 		5 ARG A  29
ALA A  22
LEU A  49
MET A 115
LEU A  36
 None
 1.03A 6f6nA-2d9jA:
undetectable
6f6nB-2d9jA:
undetectable		 6f6nA-2d9jA:
17.04
6f6nB-2d9jA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2drh 361AA LONG
HYPOTHETICAL
D-AMINOPEPTIDASE

(Pyrococcus
horikoshii) 		PF03576
(Peptidase_S58) 		5 ILE A 104
VAL A 282
ALA A  71
LEU A 134
LEU A 132
 None
 0.99A 6f6nA-2drhA:
undetectable
6f6nB-2drhA:
undetectable		 6f6nA-2drhA:
12.01
6f6nB-2drhA:
13.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ef0 ORNITHINE
CARBAMOYLTRANSFERASE

(Thermus
thermophilus) 		PF00185
(OTCace)
PF02729
(OTCace_N) 		5 VAL A 157
ALA A 216
LEU A 179
LEU A 152
LEU A 170
 None
 0.94A 6f6nA-2ef0A:
0.8
6f6nB-2ef0A:
undetectable		 6f6nA-2ef0A:
15.33
6f6nB-2ef0A:
14.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eg5 XANTHOSINE
METHYLTRANSFERASE

(Coffea
canephora) 		PF03492
(Methyltransf_7) 		5 ILE A 360
VAL A 279
LEU A 359
LEU A 223
LEU A 363
 None
 0.99A 6f6nA-2eg5A:
0.3
6f6nB-2eg5A:
undetectable		 6f6nA-2eg5A:
12.23
6f6nB-2eg5A:
16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fom POLYPROTEIN

(Dengue virus) 		PF00949
(Peptidase_S7) 		5 ILE B 165
VAL B  40
ALA B  22
LEU B 149
LEU B  85
 None
None
None
None
CL  B 201 ( 4.5A)
 0.87A 6f6nA-2fomB:
undetectable
6f6nB-2fomB:
undetectable		 6f6nA-2fomB:
22.01
6f6nB-2fomB:
17.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iht CARBOXYETHYLARGININE
SYNTHASE

(Streptomyces
clavuligerus) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		6 ILE A  41
VAL A 149
ALA A 152
LEU A  18
LEU A 168
LEU A  22
 None
 1.19A 6f6nA-2ihtA:
undetectable
6f6nB-2ihtA:
undetectable		 6f6nA-2ihtA:
8.96
6f6nB-2ihtA:
9.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2n2h PAIRED AMPHIPATHIC
HELIX PROTEIN SIN3A

(Mus musculus) 		PF08295
(Sin3_corepress) 		6 ILE B 682
VAL B 633
ALA B 636
LEU B 658
LEU B 654
LEU B 670
 None
 1.44A 6f6nA-2n2hB:
undetectable
6f6nB-2n2hB:
undetectable		 6f6nA-2n2hB:
23.33
6f6nB-2n2hB:
25.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o5v DNA REPLICATION AND
REPAIR PROTEIN RECF

(Deinococcus
radiodurans) 		PF02463
(SMC_N) 		5 ILE A 324
VAL A  72
LEU A   9
LEU A   6
LEU A  43
 None
 0.89A 6f6nA-2o5vA:
undetectable
6f6nB-2o5vA:
undetectable		 6f6nA-2o5vA:
12.20
6f6nB-2o5vA:
13.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ot9 HYPOTHETICAL PROTEIN

(Pseudomonas
syringae group
genomosp. 3) 		PF07152
(YaeQ) 		5 ILE A 148
LEU A 140
TYR A 107
LEU A  44
LEU A  45
 None
 0.91A 6f6nA-2ot9A:
0.2
6f6nB-2ot9A:
undetectable		 6f6nA-2ot9A:
18.33
6f6nB-2ot9A:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2peb PUTATIVE DIOXYGENASE

(Nostoc
punctiforme) 		PF08883
(DOPA_dioxygen) 		6 ARG A  29
VAL A  28
ALA A  25
LEU A  32
LEU A  40
LEU A  72
 None
 1.13A 6f6nA-2pebA:
undetectable
6f6nB-2pebA:
undetectable		 6f6nA-2pebA:
24.17
6f6nB-2pebA:
26.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pma UNCHARACTERIZED
PROTEIN

(Legionella
pneumophila) 		PF05618
(Zn_protease) 		5 VAL A  75
ALA A  57
LEU A  35
LEU A 118
LEU A  42
 None
 1.01A 6f6nA-2pmaA:
undetectable
6f6nB-2pmaA:
undetectable		 6f6nA-2pmaA:
21.97
6f6nB-2pmaA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qsf DNA REPAIR PROTEIN
RAD4

(Saccharomyces
cerevisiae) 		PF03835
(Rad4)
PF10403
(BHD_1)
PF10405
(BHD_3) 		5 VAL A 319
ALA A 280
LEU A 203
LEU A 182
LEU A 199
 None
 0.97A 6f6nA-2qsfA:
undetectable
6f6nB-2qsfA:
undetectable		 6f6nA-2qsfA:
9.64
6f6nB-2qsfA:
8.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wnt RIBOSOMAL PROTEIN S6
KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		6 ILE A 555
ALA A 512
LEU A 497
LEU A 553
LEU A 536
LEU A 603
 None
 1.42A 6f6nA-2wntA:
undetectable
6f6nB-2wntA:
undetectable		 6f6nA-2wntA:
14.62
6f6nB-2wntA:
13.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x9p PIMD PROTEIN

(Streptomyces
natalensis) 		PF00067
(p450) 		5 ILE A 133
VAL A 247
ALA A 251
LEU A 363
LEU A 141
 None
 1.03A 6f6nA-2x9pA:
undetectable
6f6nB-2x9pA:
undetectable		 6f6nA-2x9pA:
13.45
6f6nB-2x9pA:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xly CLOQ

(Streptomyces
roseochromogenus) 		PF11468
(PTase_Orf2) 		5 VAL A 173
ALA A 162
LEU A 220
LEU A 222
LEU A 135
 None
 0.97A 6f6nA-2xlyA:
undetectable
6f6nB-2xlyA:
undetectable		 6f6nA-2xlyA:
15.14
6f6nB-2xlyA:
13.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yzw ADP-RIBOSYLGLYCOHYDR
OLASE

(Thermus
thermophilus) 		PF03747
(ADP_ribosyl_GH) 		5 VAL A 170
ALA A 167
LEU A 174
LEU A 188
LEU A 190
 None
 0.95A 6f6nA-2yzwA:
undetectable
6f6nB-2yzwA:
undetectable		 6f6nA-2yzwA:
14.98
6f6nB-2yzwA:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zet RAS-RELATED PROTEIN
RAB-27B

(Mus musculus) 		PF00071
(Ras) 		5 VAL A  51
LEU A  70
LEU A  72
LEU A 177
LEU A 178
 None
 0.74A 6f6nA-2zetA:
undetectable
6f6nB-2zetA:
undetectable		 6f6nA-2zetA:
17.92
6f6nB-2zetA:
13.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aov PUTATIVE
UNCHARACTERIZED
PROTEIN PH0207

(Pyrococcus
horikoshii) 		PF00155
(Aminotran_1_2) 		5 ILE A 359
VAL A 381
ALA A 376
LEU A  61
LEU A 340
 None
 0.95A 6f6nA-3aovA:
undetectable
6f6nB-3aovA:
undetectable		 6f6nA-3aovA:
11.09
6f6nB-3aovA:
10.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bc1 RAS-RELATED PROTEIN
RAB-27A

(Mus musculus) 		PF00071
(Ras) 		5 VAL A  51
LEU A  70
LEU A  72
LEU A 177
LEU A 178
 None
 0.94A 6f6nA-3bc1A:
undetectable
6f6nB-3bc1A:
undetectable		 6f6nA-3bc1A:
18.82
6f6nB-3bc1A:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3da8 PROBABLE
5'-PHOSPHORIBOSYLGLY
CINAMIDE
FORMYLTRANSFERASE
PURN

(Mycobacterium
tuberculosis) 		PF00551
(Formyl_trans_N) 		5 VAL A 191
ALA A 190
LEU A  29
LEU A  25
LEU A  15
 None
None
None
IOD  A 603 ( 4.6A)
None
 0.96A 6f6nA-3da8A:
undetectable
6f6nB-3da8A:
undetectable		 6f6nA-3da8A:
18.93
6f6nB-3da8A:
14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ejb BIOTIN BIOSYNTHESIS
CYTOCHROME P450-LIKE
ENZYME

(Bacillus
subtilis) 		PF00067
(p450) 		5 VAL B 391
LEU B 368
LEU B 361
LEU B 250
LEU B 251
 None
 1.02A 6f6nA-3ejbB:
undetectable
6f6nB-3ejbB:
undetectable		 6f6nA-3ejbB:
12.15
6f6nB-3ejbB:
13.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eto NEUROGENIC LOCUS
NOTCH HOMOLOG
PROTEIN 1

(Homo sapiens) 		PF00066
(Notch)
PF06816
(NOD)
PF07684
(NODP) 		5 ILE A1715
VAL A1700
ALA A1697
LEU A1704
LEU A1601
 None
 1.04A 6f6nA-3etoA:
undetectable
6f6nB-3etoA:
undetectable		 6f6nA-3etoA:
14.23
6f6nB-3etoA:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g8a RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G

(Thermus
thermophilus) 		PF02527
(GidB) 		5 VAL A 224
ALA A 182
LEU A 206
LEU A 199
LEU A 192
 None
 0.64A 6f6nA-3g8aA:
undetectable
6f6nB-3g8aA:
undetectable		 6f6nA-3g8aA:
15.61
6f6nB-3g8aA:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gl5 PUTATIVE DSBA
OXIDOREDUCTASE
SCO1869

(Streptomyces
coelicolor) 		PF01323
(DSBA) 		5 VAL A 153
ALA A 150
LEU A 157
LEU A 101
LEU A 104
 None
 1.03A 6f6nA-3gl5A:
undetectable
6f6nB-3gl5A:
undetectable		 6f6nA-3gl5A:
17.54
6f6nB-3gl5A:
17.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gue UTP-GLUCOSE-1-PHOSPH
ATE
URIDYLYLTRANSFERASE
2

(Trypanosoma
brucei) 		PF01704
(UDPGP) 		5 VAL A 364
LEU A 242
LEU A 239
LEU A 231
LEU A 230
 None
 0.93A 6f6nA-3gueA:
undetectable
6f6nB-3gueA:
undetectable		 6f6nA-3gueA:
12.39
6f6nB-3gueA:
10.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hzj RAB
GTPASE-ACTIVATING
PROTEIN 1-LIKE

(Homo sapiens) 		PF00566
(RabGAP-TBC) 		5 VAL A 535
LEU A 531
LEU A 516
LEU A 550
LEU A 551
 None
 0.99A 6f6nA-3hzjA:
undetectable
6f6nB-3hzjA:
undetectable		 6f6nA-3hzjA:
15.33
6f6nB-3hzjA:
13.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3izq ELONGATION FACTOR 1
ALPHA-LIKE PROTEIN

(Saccharomyces
cerevisiae) 		PF00009
(GTP_EFTU)
PF03143
(GTP_EFTU_D3)
PF08938
(HBS1_N) 		5 ARG 1 256
VAL 1 259
ALA 1 252
LEU 1 298
LEU 1 299
 None
 0.88A 6f6nA-3izq1:
undetectable
6f6nB-3izq1:
undetectable		 6f6nA-3izq1:
7.61
6f6nB-3izq1:
9.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jur EXO-POLY-ALPHA-D-GAL
ACTURONOSIDASE

(Thermotoga
maritima) 		PF00295
(Glyco_hydro_28)
PF12708
(Pectate_lyase_3) 		5 VAL A 390
ALA A 389
LEU A 424
LEU A 439
LEU A 404
 None
 1.04A 6f6nA-3jurA:
undetectable
6f6nB-3jurA:
undetectable		 6f6nA-3jurA:
12.24
6f6nB-3jurA:
12.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k4w UNCHARACTERIZED
PROTEIN BB4693

(Bordetella
bronchiseptica) 		PF04909
(Amidohydro_2) 		5 ILE A   4
VAL A 185
LEU A 237
LEU A 276
LEU A 275
 None
 1.00A 6f6nA-3k4wA:
undetectable
6f6nB-3k4wA:
undetectable		 6f6nA-3k4wA:
14.49
6f6nB-3k4wA:
13.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lpz GET4 (YOR164C
HOMOLOG)

(Chaetomium
thermophilum) 		PF04190
(DUF410) 		5 VAL A 187
ALA A 186
LEU A 238
LEU A 229
LEU A 245
 None
 1.01A 6f6nA-3lpzA:
undetectable
6f6nB-3lpzA:
undetectable		 6f6nA-3lpzA:
13.79
6f6nB-3lpzA:
12.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mru AMINOACYL-HISTIDINE
DIPEPTIDASE

(Vibrio
alginolyticus) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		5 VAL A 130
ALA A 129
LEU A  77
LEU A 482
LEU A 483
 None
 0.88A 6f6nA-3mruA:
undetectable
6f6nB-3mruA:
undetectable		 6f6nA-3mruA:
10.56
6f6nB-3mruA:
9.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nap CAPSID PROTEIN

(Triatoma virus) 		PF00073
(Rhv)
PF08762
(CRPV_capsid) 		5 ILE C  62
ALA B 214
LEU B 178
LEU A 230
LEU A 231
 None
 1.03A 6f6nA-3napC:
undetectable
6f6nB-3napC:
undetectable		 6f6nA-3napC:
14.55
6f6nB-3napC:
16.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rmg OCTAPRENYL-DIPHOSPHA
TE SYNTHASE

(Bacteroides
thetaiotaomicron) 		PF00348
(polyprenyl_synt) 		5 VAL A  56
ALA A 183
LEU A 200
LEU A 316
LEU A 312
 None
 1.04A 6f6nA-3rmgA:
undetectable
6f6nB-3rmgA:
undetectable		 6f6nA-3rmgA:
15.21
6f6nB-3rmgA:
13.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3s88 ENVELOPE
GLYCOPROTEIN

(Sudan
ebolavirus) 		PF01611
(Filo_glycop)
no annotation 		6 VAL I  66
ALA I 101
LEU I 184
LEU I 186
TYR J 517
LEU J 558
 None
 0.72A 6f6nA-3s88I:
28.6
6f6nB-3s88I:
undetectable		 6f6nA-3s88I:
74.39
6f6nB-3s88I:
14.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sqo PCSK9 PRODOMAIN

(Homo sapiens) 		PF05922
(Inhibitor_I9) 		5 ARG P  97
LEU P  98
LEU P 137
LEU P 131
LEU P 130
 None
 1.03A 6f6nA-3sqoP:
undetectable
6f6nB-3sqoP:
undetectable		 6f6nA-3sqoP:
20.17
6f6nB-3sqoP:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uk6 RUVB-LIKE 2

(Homo sapiens) 		PF06068
(TIP49) 		5 ILE A 346
ALA A 122
LEU A 312
LEU A 304
LEU A 324
 None
 0.96A 6f6nA-3uk6A:
undetectable
6f6nB-3uk6A:
undetectable		 6f6nA-3uk6A:
12.50
6f6nB-3uk6A:
11.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wnp CYCLOISOMALTOOLIGOSA
CCHARIDE
GLUCANOTRANSFERASE

(Bacillus
circulans) 		PF13199
(Glyco_hydro_66)
PF16990
(CBM_35) 		5 VAL A 307
ALA A 234
LEU A 351
LEU A 341
LEU A 334
 None
 0.81A 6f6nA-3wnpA:
undetectable
6f6nB-3wnpA:
undetectable		 6f6nA-3wnpA:
8.26
6f6nB-3wnpA:
8.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wxx ACRH
AOPB

(Aeromonas
hydrophila) 		PF04888
(SseC)
no annotation 		6 ILE A  56
VAL A  29
LEU B  72
LEU B  69
LEU A  60
LEU A  63
 None
 1.38A 6f6nA-3wxxA:
undetectable
6f6nB-3wxxA:
undetectable		 6f6nA-3wxxA:
17.61
6f6nB-3wxxA:
24.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bju N-ACETYLGLUCOSAMINE-
PHOSPHATE MUTASE

(Aspergillus
fumigatus) 		PF00408
(PGM_PMM_IV)
PF02878
(PGM_PMM_I) 		5 VAL A 214
ALA A 281
LEU A 238
LEU A 228
LEU A 225
 None
 0.90A 6f6nA-4bjuA:
undetectable
6f6nB-4bjuA:
undetectable		 6f6nA-4bjuA:
11.09
6f6nB-4bjuA:
10.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4brj DESULFOFERRODOXIN,
FERROUS IRON-BINDING
REGION

(Ignicoccus
hospitalis) 		PF01880
(Desulfoferrodox) 		5 VAL A  43
ALA A  31
LEU A  95
LEU A  97
LEU A  63
 None
 0.76A 6f6nA-4brjA:
undetectable
6f6nB-4brjA:
undetectable		 6f6nA-4brjA:
22.58
6f6nB-4brjA:
24.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4da1 PROTEIN PHOSPHATASE
1K, MITOCHONDRIAL

(Homo sapiens) 		PF00481
(PP2C) 		5 VAL A 120
LEU A 156
TYR A 122
LEU A 149
LEU A 150
 None
 1.04A 6f6nA-4da1A:
0.0
6f6nB-4da1A:
undetectable		 6f6nA-4da1A:
12.78
6f6nB-4da1A:
13.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dav SUGAR FERMENTATION
STIMULATION PROTEIN
HOMOLOG

(Pyrococcus
furiosus) 		PF03749
(SfsA) 		5 VAL A 172
LEU A 210
LEU A 212
LEU A  95
LEU A  96
 None
 0.90A 6f6nA-4davA:
undetectable
6f6nB-4davA:
undetectable		 6f6nA-4davA:
16.37
6f6nB-4davA:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4egs RIBOSE 5-PHOSPHATE
ISOMERASE RPIB

(Caldanaerobacter
subterraneus) 		PF01451
(LMWPc) 		5 VAL A   3
ALA A  34
LEU A  83
LEU A 138
LEU A 142
 VAL  A   3 ( 0.6A)
ALA  A  34 ( 0.0A)
LEU  A  83 ( 0.6A)
LEU  A 138 ( 0.6A)
LEU  A 142 ( 0.5A)
 1.01A 6f6nA-4egsA:
undetectable
6f6nB-4egsA:
undetectable		 6f6nA-4egsA:
15.56
6f6nB-4egsA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f48 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Xanthomonas
campestris) 		PF00563
(EAL) 		6 ILE A 211
VAL A 135
ALA A 142
LEU A 158
LEU A 171
LEU A 170
 None
 1.34A 6f6nA-4f48A:
undetectable
6f6nB-4f48A:
undetectable		 6f6nA-4f48A:
15.60
6f6nB-4f48A:
15.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g1g MATRIX PROTEIN

(Avian
avulavirus 1) 		PF00661
(Matrix) 		5 ILE A 261
VAL A 280
ALA A 300
LEU A 266
LEU A 206
 None
 0.99A 6f6nA-4g1gA:
undetectable
6f6nB-4g1gA:
undetectable		 6f6nA-4g1gA:
12.15
6f6nB-4g1gA:
12.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g1g MATRIX PROTEIN

(Avian
avulavirus 1) 		PF00661
(Matrix) 		5 VAL A 280
ALA A 300
LEU A 266
LEU A 264
LEU A 206
 None
 0.84A 6f6nA-4g1gA:
undetectable
6f6nB-4g1gA:
undetectable		 6f6nA-4g1gA:
12.15
6f6nB-4g1gA:
12.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ib2 PUTATIVE LIPOPROTEIN

([Ruminococcus]
gnavus) 		PF03180
(Lipoprotein_9) 		5 ILE A  58
VAL A  41
ALA A  88
LEU A  66
LEU A  52
 None
 0.76A 6f6nA-4ib2A:
undetectable
6f6nB-4ib2A:
undetectable		 6f6nA-4ib2A:
18.06
6f6nB-4ib2A:
16.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nc6 RAB
GTPASE-ACTIVATING
PROTEIN 1

(Homo sapiens) 		PF00566
(RabGAP-TBC) 		5 VAL A 563
LEU A 559
LEU A 544
LEU A 578
LEU A 579
 None
 0.95A 6f6nA-4nc6A:
undetectable
6f6nB-4nc6A:
undetectable		 6f6nA-4nc6A:
13.42
6f6nB-4nc6A:
12.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nhr LPS-ASSEMBLY
LIPOPROTEIN LPTE

(Escherichia
coli) 		PF04390
(LptE) 		5 VAL A 104
ALA A 120
LEU A  77
LEU A  75
LEU A  47
 None
 0.94A 6f6nA-4nhrA:
1.2
6f6nB-4nhrA:
undetectable		 6f6nA-4nhrA:
18.25
6f6nB-4nhrA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nkh E3 UBIQUITIN-PROTEIN
LIGASE SSPH1

(Salmonella
enterica) 		no annotation 5 VAL A 284
LEU A 289
LEU A 309
MET A 295
LEU A 272
 None
 0.84A 6f6nA-4nkhA:
undetectable
6f6nB-4nkhA:
undetectable		 6f6nA-4nkhA:
15.19
6f6nB-4nkhA:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o8s PUTATIVE

(Helicobacter
pylori) 		PF08843
(AbiEii) 		5 ARG A  69
VAL A  70
ALA A  73
LEU A  66
LEU A 112
 None
 0.90A 6f6nA-4o8sA:
undetectable
6f6nB-4o8sA:
undetectable		 6f6nA-4o8sA:
20.00
6f6nB-4o8sA:
13.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ok0 PUTATIVE

(Helicobacter
pylori) 		PF08843
(AbiEii) 		5 ARG A  69
VAL A  70
ALA A  73
LEU A  66
LEU A 112
 None
 0.82A 6f6nA-4ok0A:
undetectable
6f6nB-4ok0A:
undetectable		 6f6nA-4ok0A:
14.57
6f6nB-4ok0A:
13.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ote LIPOPROTEIN

(Clostridioides
difficile) 		PF03180
(Lipoprotein_9) 		5 VAL A  33
ALA A  35
LEU A 240
LEU A 244
LEU A  58
 None
 1.03A 6f6nA-4oteA:
undetectable
6f6nB-4oteA:
undetectable		 6f6nA-4oteA:
17.14
6f6nB-4oteA:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pug BOLA LIKE PROTEIN

(Arabidopsis
thaliana) 		PF01722
(BolA) 		5 ARG A  73
ALA A  69
LEU A  76
LEU A  85
LEU A 135
 None
 1.02A 6f6nA-4pugA:
undetectable
6f6nB-4pugA:
undetectable		 6f6nA-4pugA:
21.15
6f6nB-4pugA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4s1w GLUTAMINE--FRUCTOSE-
6-PHOSPHATE
AMINOTRANSFERASE
[ISOMERIZING]

(Staphylococcus
aureus) 		PF01380
(SIS) 		6 ILE A 345
VAL A 288
ALA A 291
LEU A 369
LEU A 410
LEU A 413
 None
 1.10A 6f6nA-4s1wA:
undetectable
6f6nB-4s1wA:
undetectable		 6f6nA-4s1wA:
10.32
6f6nB-4s1wA:
13.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uoe SPERMIDINE SYNTHASE

(Plasmodium
falciparum) 		PF01564
(Spermine_synth)
PF17284
(Spermine_synt_N) 		5 ILE A  92
VAL A 152
LEU A  86
LEU A  94
LEU A  88
 None
MTA  A 401 (-4.3A)
None
None
None
 1.04A 6f6nA-4uoeA:
undetectable
6f6nB-4uoeA:
undetectable		 6f6nA-4uoeA:
17.25
6f6nB-4uoeA:
13.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ye5 PEPTIDOGLYCAN
SYNTHETASE
PENICILLIN-BINDING
PROTEIN 3

(Bifidobacterium
adolescentis) 		PF00905
(Transpeptidase)
PF03717
(PBP_dimer) 		5 VAL A 125
ALA A 122
LEU A 129
LEU A 153
LEU A 170
 None
 1.03A 6f6nA-4ye5A:
undetectable
6f6nB-4ye5A:
undetectable		 6f6nA-4ye5A:
11.39
6f6nB-4ye5A:
9.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a0t RIBONUCLEASE J

(Streptomyces
coelicolor) 		PF00753
(Lactamase_B)
PF07521
(RMMBL) 		5 ILE A  45
LEU A 105
LEU A  82
LEU A  96
LEU A  97
 None
 0.96A 6f6nA-5a0tA:
undetectable
6f6nB-5a0tA:
undetectable		 6f6nA-5a0tA:
9.34
6f6nB-5a0tA:
9.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cwa ANTHRANILATE
SYNTHASE COMPONENT 1

(Mycobacterium
tuberculosis) 		PF00425
(Chorismate_bind)
PF04715
(Anth_synt_I_N) 		5 ARG A  22
VAL A 182
LEU A 111
LEU A  77
LEU A 161
 None
 1.00A 6f6nA-5cwaA:
undetectable
6f6nB-5cwaA:
undetectable		 6f6nA-5cwaA:
10.83
6f6nB-5cwaA:
9.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cwe CYTOCHROME P450
HYDROXYLASE

(Streptomyces
avermitilis) 		PF00067
(p450) 		5 VAL A 391
LEU A 368
LEU A 361
LEU A 249
LEU A 250
 None
 1.01A 6f6nA-5cweA:
undetectable
6f6nB-5cweA:
undetectable		 6f6nA-5cweA:
11.43
6f6nB-5cweA:
10.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dud YBGK

(Escherichia
coli) 		PF02626
(CT_A_B) 		6 ILE A  55
VAL A  86
ALA A  85
LEU A  72
LEU A  60
LEU A 100
 None
 1.20A 6f6nA-5dudA:
undetectable
6f6nB-5dudA:
undetectable		 6f6nA-5dudA:
13.87
6f6nB-5dudA:
12.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gnm VITAMIN D(3)
25-HYDROXYLASE

(Pseudonocardia
autotrophica) 		PF00067
(p450) 		5 VAL A 396
LEU A 371
LEU A 364
LEU A 252
LEU A 253
 None
 0.98A 6f6nA-5gnmA:
undetectable
6f6nB-5gnmA:
undetectable		 6f6nA-5gnmA:
13.96
6f6nB-5gnmA:
11.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hiw CYTOCHROME P450
CYP260B1

(Sorangium
cellulosum) 		PF00067
(p450) 		5 ALA A 121
LEU A 241
LEU A 245
LEU A 356
LEU A 355
 None
 0.97A 6f6nA-5hiwA:
undetectable
6f6nB-5hiwA:
undetectable		 6f6nA-5hiwA:
10.78
6f6nB-5hiwA:
11.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hx0 UNCHARACTERIZED
PROTEIN DFER_1899

(Dyadobacter
fermentans) 		PF13088
(BNR_2) 		5 ILE A  36
VAL A 378
ALA A 368
LEU A 396
LEU A 354
 None
 0.87A 6f6nA-5hx0A:
undetectable
6f6nB-5hx0A:
undetectable		 6f6nA-5hx0A:
12.41
6f6nB-5hx0A:
13.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kdx METALLOPEPTIDASE

(Pseudomonas
aeruginosa) 		PF13402
(Peptidase_M60) 		5 VAL A 162
ALA A 161
LEU A 194
LEU A 144
LEU A 220
 None
 1.04A 6f6nA-5kdxA:
undetectable
6f6nB-5kdxA:
undetectable		 6f6nA-5kdxA:
6.87
6f6nB-5kdxA:
6.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ken EBOLA SURFACE
GLYCOPROTEIN, GP1
EBOLA SURFACE
GLYCOPROTEIN, GP2

(Zaire
ebolavirus) 		PF01611
(Filo_glycop)
no annotation 		5 ARG A  64
LEU A 186
TYR B 517
LEU B 554
LEU B 558
 None
 0.74A 6f6nA-5kenA:
23.3
6f6nB-5kenA:
undetectable		 6f6nA-5kenA:
98.67
6f6nB-5kenA:
15.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ken EBOLA SURFACE
GLYCOPROTEIN, GP1
EBOLA SURFACE
GLYCOPROTEIN, GP2

(Zaire
ebolavirus) 		PF01611
(Filo_glycop)
no annotation 		5 VAL A  66
LEU A 184
LEU A 186
MET B 548
LEU B 558
 None
 1.01A 6f6nA-5kenA:
23.3
6f6nB-5kenA:
undetectable		 6f6nA-5kenA:
98.67
6f6nB-5kenA:
15.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ken EBOLA SURFACE
GLYCOPROTEIN, GP1
EBOLA SURFACE
GLYCOPROTEIN, GP2

(Zaire
ebolavirus) 		PF01611
(Filo_glycop)
no annotation 		6 VAL A  66
LEU A 184
LEU A 186
TYR B 517
LEU B 554
LEU B 558
 None
 0.78A 6f6nA-5kenA:
23.3
6f6nB-5kenA:
undetectable		 6f6nA-5kenA:
98.67
6f6nB-5kenA:
15.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kuf GLUTAMATE RECEPTOR
IONOTROPIC, KAINATE
2

(Rattus
norvegicus) 		PF00060
(Lig_chan)
PF01094
(ANF_receptor)
PF10613
(Lig_chan-Glu_bd) 		5 VAL A 303
ALA A 302
LEU A  40
LEU A  39
LEU A  45
 None
 1.01A 6f6nA-5kufA:
undetectable
6f6nB-5kufA:
undetectable		 6f6nA-5kufA:
7.20
6f6nB-5kufA:
6.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kvm ADHESION G-PROTEIN
COUPLED RECEPTOR G1

(Mus musculus) 		PF01825
(GPS) 		5 VAL A 273
ALA A 272
LEU A 269
LEU A 268
LEU A 382
 None
 1.02A 6f6nA-5kvmA:
undetectable
6f6nB-5kvmA:
undetectable		 6f6nA-5kvmA:
11.97
6f6nB-5kvmA:
11.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5liv CYTOCHROME P450
CYP260A1,CYTOCHROME
P450 CYP260A1

(Sorangium
cellulosum) 		PF00067
(p450) 		5 VAL A 441
LEU A 414
LEU A 407
LEU A 295
LEU A 296
 None
 1.01A 6f6nA-5livA:
undetectable
6f6nB-5livA:
undetectable		 6f6nA-5livA:
10.79
6f6nB-5livA:
11.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nmi CYTOCHROME B-C1
COMPLEX SUBUNIT 1,
MITOCHONDRIAL

(Bos taurus) 		PF00675
(Peptidase_M16)
PF05193
(Peptidase_M16_C) 		5 VAL A 110
ALA A 109
LEU A 208
LEU A 203
LEU A 197
 None
 0.97A 6f6nA-5nmiA:
undetectable
6f6nB-5nmiA:
undetectable		 6f6nA-5nmiA:
11.76
6f6nB-5nmiA:
13.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5olt -

(-) 		no annotation 5 VAL A 250
ALA A 253
LEU A 245
LEU A 395
LEU A 421
 None
 0.98A 6f6nA-5oltA:
undetectable
6f6nB-5oltA:
undetectable		 6f6nA-5oltA:
undetectable
6f6nB-5oltA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uz5 56 KDA U1 SMALL
NUCLEAR
RIBONUCLEOPROTEIN
COMPONENT

(Saccharomyces
cerevisiae) 		no annotation 5 ILE G 115
VAL G 203
LEU G  70
LEU G 132
LEU G 133
 None
 0.99A 6f6nA-5uz5G:
undetectable
6f6nB-5uz5G:
undetectable		 6f6nA-5uz5G:
9.55
6f6nB-5uz5G:
9.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w0m TERMINAL
URIDYLYLTRANSFERASE
7

(Homo sapiens) 		PF00098
(zf-CCHC)
PF03828
(PAP_assoc) 		5 ILE A1120
ALA A1021
LEU A1059
LEU A1042
LEU A1044
 None
 1.02A 6f6nA-5w0mA:
undetectable
6f6nB-5w0mA:
undetectable		 6f6nA-5w0mA:
17.75
6f6nB-5w0mA:
10.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wx3 ALKYLDIKETIDE-COA
SYNTHASE

(Tetradium
ruticarpum) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		5 VAL A 183
ALA A 215
LEU A 120
LEU A 117
LEU A 137
 None
 0.83A 6f6nA-5wx3A:
undetectable
6f6nB-5wx3A:
undetectable		 6f6nA-5wx3A:
11.87
6f6nB-5wx3A:
14.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xyi UNCHARACTERIZED
PROTEIN

(Trichomonas
vaginalis) 		PF00163
(Ribosomal_S4)
PF01479
(S4) 		6 ARG J  51
VAL J  94
ALA J  54
LEU J  97
LEU J  47
LEU J  78
 None
 1.40A 6f6nA-5xyiJ:
undetectable
6f6nB-5xyiJ:
undetectable		 6f6nA-5xyiJ:
18.87
6f6nB-5xyiJ:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6a2f -

(-) 		no annotation 5 ILE A 241
VAL A 287
ALA A 294
LEU A 240
LEU A 305
 None
 1.01A 6f6nA-6a2fA:
undetectable
6f6nB-6a2fA:
undetectable		 6f6nA-6a2fA:
undetectable
6f6nB-6a2fA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bb9 4-AMINO-4-DEOXYCHORI
SMATE LYASE

(Salmonella
enterica) 		no annotation 5 VAL A 226
ALA A 225
LEU A 163
LEU A 165
LEU A 179
 None
 0.98A 6f6nA-6bb9A:
undetectable
6f6nB-6bb9A:
undetectable		 6f6nA-6bb9A:
14.71
6f6nB-6bb9A:
15.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cgm RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE

(Bacillus
subtilis) 		no annotation 5 ILE A 578
ARG A 575
LEU A 463
LEU A 576
LEU A 414
 None
 0.98A 6f6nA-6cgmA:
undetectable
6f6nB-6cgmA:
undetectable		 6f6nA-6cgmA:
18.18
6f6nB-6cgmA:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cgm RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE

(Bacillus
subtilis) 		no annotation 5 ILE A 578
VAL A 429
LEU A 463
LEU A 576
LEU A 414
 None
 0.91A 6f6nA-6cgmA:
undetectable
6f6nB-6cgmA:
undetectable		 6f6nA-6cgmA:
18.18
6f6nB-6cgmA:
18.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6f5u ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1

(Zaire
ebolavirus) 		no annotation 6 ILE A  38
ARG A  64
VAL A  66
ALA A 101
LEU A 184
LEU A 186
 None
CQN  A 610 (-3.8A)
CQN  A 610 (-4.0A)
CQN  A 610 (-3.4A)
CQN  A 610 ( 4.6A)
None
 0.43A 6f6nA-6f5uA:
36.6
6f6nB-6f5uA:
undetectable		 6f6nA-6f5uA:
100.00
6f6nB-6f5uA:
10.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6f6s ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1

(Zaire
ebolavirus) 		no annotation 6 ILE A  38
ARG A  64
VAL A  66
ALA A 101
LEU A 184
LEU A 186
 None
CXQ  A 507 (-3.6A)
None
CXQ  A 507 (-3.6A)
None
None
 0.32A 6f6nA-6f6sA:
36.6
6f6nB-6f6sA:
undetectable		 6f6nA-6f6sA:
100.00
6f6nB-6f6sA:
10.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f8l -

(-) 		no annotation 5 ILE G 467
VAL G 444
ALA G 447
LEU G 431
LEU G 430
 None
 1.02A 6f6nA-6f8lG:
undetectable
6f6nB-6f8lG:
undetectable		 6f6nA-6f8lG:
undetectable
6f6nB-6f8lG:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6h7x -

(-) 		no annotation 5 ILE A 346
ALA A 122
LEU A 312
LEU A 304
LEU A 324
 None
 0.96A 6f6nA-6h7xA:
undetectable
6f6nB-6h7xA:
undetectable		 6f6nA-6h7xA:
undetectable
6f6nB-6h7xA:
undetectable