SIMILAR PATTERNS OF AMINO ACIDS FOR 6F6J_D_ACTD404_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gpl RP2 LIPASE

(Cavia porcellus) 		PF00151
(Lipase)
PF01477
(PLAT) 		4 GLU A  14
TRP A  17
ALA A  18
GLN A 119
 None
 1.29A 6f6jC-1gplA:
0.0
6f6jD-1gplA:
0.0		 6f6jC-1gplA:
20.00
6f6jD-1gplA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gyt CYTOSOL
AMINOPEPTIDASE

(Escherichia
coli) 		PF00883
(Peptidase_M17)
PF02789
(Peptidase_M17_N) 		4 GLN A 491
GLU A 405
ALA A 408
GLN A 412
 None
 1.49A 6f6jC-1gytA:
0.1
6f6jD-1gytA:
0.1		 6f6jC-1gytA:
22.82
6f6jD-1gytA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k5d RAN-SPECIFIC
GTPASE-ACTIVATING
PROTEIN

(Homo sapiens) 		PF00638
(Ran_BP1) 		4 GLU B 136
TRP B 122
HIS B 102
ALA B 100
 GLU  B 136 ( 0.5A)
TRP  B 122 ( 0.5A)
HIS  B 102 ( 1.0A)
ALA  B 100 ( 0.0A)
 1.39A 6f6jC-1k5dB:
0.0
6f6jD-1k5dB:
0.0		 6f6jC-1k5dB:
19.34
6f6jD-1k5dB:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k7y METHIONINE SYNTHASE

(Escherichia
coli) 		PF02310
(B12-binding)
PF02607
(B12-binding_2)
PF02965
(Met_synt_B12) 		4 GLN A1199
GLU A 907
ALA A 909
GLN A1032
 None
 1.36A 6f6jC-1k7yA:
0.0
6f6jD-1k7yA:
0.2		 6f6jC-1k7yA:
22.05
6f6jD-1k7yA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kwg BETA-GALACTOSIDASE

(Thermus
thermophilus) 		PF02449
(Glyco_hydro_42)
PF08532
(Glyco_hydro_42M)
PF08533
(Glyco_hydro_42C) 		4 GLN A 361
GLU A 360
HIS A  10
ALA A 355
 None
 1.20A 6f6jC-1kwgA:
0.0
6f6jD-1kwgA:
0.0		 6f6jC-1kwgA:
22.21
6f6jD-1kwgA:
22.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mhz METHANE
MONOOXYGENASE
HYDROXYLASE

(Methylosinus
trichosporium) 		PF02332
(Phenol_Hydrox) 		4 GLN D 369
GLU D 367
TRP D 371
ALA D 370
 None
 1.35A 6f6jC-1mhzD:
0.0
6f6jD-1mhzD:
0.0		 6f6jC-1mhzD:
20.56
6f6jD-1mhzD:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mp3 GLUCOSE-1-PHOSPHATE
THYMIDYLYLTRANSFERAS
E

(Salmonella
enterica) 		PF00483
(NTP_transferase) 		4 GLN A  83
GLU A 197
ALA A  90
GLN A  91
 TTP  A 501 (-2.9A)
TTP  A 501 ( 4.9A)
None
None
 1.45A 6f6jC-1mp3A:
0.0
6f6jD-1mp3A:
0.0		 6f6jC-1mp3A:
20.75
6f6jD-1mp3A:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1odo PUTATIVE CYTOCHROME
P450 154A1

(Streptomyces
coelicolor) 		PF00067
(p450) 		4 GLN A  39
GLU A 313
TRP A  66
ALA A  40
 None
 1.39A 6f6jC-1odoA:
0.0
6f6jD-1odoA:
0.0		 6f6jC-1odoA:
24.38
6f6jD-1odoA:
24.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1odo PUTATIVE CYTOCHROME
P450 154A1

(Streptomyces
coelicolor) 		PF00067
(p450) 		4 GLU A 313
TRP A  66
ALA A  40
GLN A  39
 None
 1.32A 6f6jC-1odoA:
0.0
6f6jD-1odoA:
0.0		 6f6jC-1odoA:
24.38
6f6jD-1odoA:
24.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q2l PROTEASE III

(Escherichia
coli) 		PF00675
(Peptidase_M16)
PF05193
(Peptidase_M16_C)
PF16187
(Peptidase_M16_M) 		4 GLN A  31
GLU A  32
ALA A  46
GLN A  45
 None
 1.39A 6f6jC-1q2lA:
0.0
6f6jD-1q2lA:
0.0		 6f6jC-1q2lA:
18.54
6f6jD-1q2lA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qon ACETYLCHOLINESTERASE

(Drosophila
melanogaster) 		PF00135
(COesterase) 		4 GLU A 528
TRP A 529
ALA A 523
GLN A 524
 None
 1.30A 6f6jC-1qonA:
undetectable
6f6jD-1qonA:
undetectable		 6f6jC-1qonA:
20.70
6f6jD-1qonA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sq7 TRIOSEPHOSPHATE
ISOMERASE

(Gallus gallus) 		PF00121
(TIM) 		4 GLN A 182
GLU A 183
ALA A 181
GLN A 223
 None
 1.33A 6f6jC-1sq7A:
undetectable
6f6jD-1sq7A:
undetectable		 6f6jC-1sq7A:
19.06
6f6jD-1sq7A:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vg5 RHOMBOID FAMILY
PROTEIN

(Arabidopsis
thaliana) 		PF00627
(UBA) 		4 GLN A  45
GLU A  47
ALA A  49
GLN A  67
 None
 1.33A 6f6jC-1vg5A:
undetectable
6f6jD-1vg5A:
undetectable		 6f6jC-1vg5A:
14.25
6f6jD-1vg5A:
14.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wms RAS-RELATED PROTEIN
RAB-9A

(Homo sapiens) 		PF00071
(Ras) 		4 GLN A 139
GLU A 137
TRP A 141
ALA A 140
 None
 1.27A 6f6jC-1wmsA:
undetectable
6f6jD-1wmsA:
undetectable		 6f6jC-1wmsA:
19.78
6f6jD-1wmsA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yrg GTPASE-ACTIVATING
PROTEIN RNA1_SCHPO

(Schizosaccharomyces
pombe) 		no annotation 4 GLU A 178
HIS A 206
ALA A 180
GLN A 184
 None
 1.50A 6f6jC-1yrgA:
undetectable
6f6jD-1yrgA:
undetectable		 6f6jC-1yrgA:
22.17
6f6jD-1yrgA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z3i SIMILAR TO
RAD54-LIKE

(Danio rerio) 		PF00176
(SNF2_N)
PF00271
(Helicase_C) 		4 GLU X 352
HIS X 334
ALA X 344
GLN X 345
 None
 1.45A 6f6jC-1z3iX:
undetectable
6f6jD-1z3iX:
undetectable		 6f6jC-1z3iX:
20.18
6f6jD-1z3iX:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zef ALKALINE PHOSPHATASE

(Homo sapiens) 		PF00245
(Alk_phosphatase) 		4 GLN A 235
GLU A 236
TRP A 237
ALA A 239
 None
 1.21A 6f6jC-1zefA:
undetectable
6f6jD-1zefA:
undetectable		 6f6jC-1zefA:
22.29
6f6jD-1zefA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a9c SULFITE OXIDASE

(Gallus gallus) 		PF00174
(Oxidored_molyb)
PF03404
(Mo-co_dimer) 		4 GLN A 318
TRP A 317
HIS A 140
ALA A 297
 None
None
MTE  A1501 (-3.6A)
MTE  A1501 (-3.7A)
 1.47A 6f6jC-2a9cA:
undetectable
6f6jD-2a9cA:
undetectable		 6f6jC-2a9cA:
23.89
6f6jD-2a9cA:
23.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aps PROTEIN (CU,ZN
SUPEROXIDE
DISMUTASE)

(Actinobacillus
pleuropneumoniae) 		PF00080
(Sod_Cu) 		4 GLN A  21
GLU A 142
HIS A  57
ALA A  53
 None
 1.39A 6f6jC-2apsA:
undetectable
6f6jD-2apsA:
undetectable		 6f6jC-2apsA:
17.27
6f6jD-2apsA:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b3b GLUCOSE-BINDING
PROTEIN

(Thermus
thermophilus) 		PF01547
(SBP_bac_1) 		4 GLN A 226
GLU A 165
TRP A 224
ALA A 227
 None
None
GLC  A2605 ( 4.5A)
None
 1.33A 6f6jC-2b3bA:
undetectable
6f6jD-2b3bA:
undetectable		 6f6jC-2b3bA:
23.04
6f6jD-2b3bA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b4e CORONIN-1A

(Mus musculus) 		PF00400
(WD40)
PF08953
(DUF1899)
PF16300
(WD40_4) 		4 GLN A 262
GLU A 263
HIS A 218
ALA A 248
 None
 1.36A 6f6jC-2b4eA:
undetectable
6f6jD-2b4eA:
undetectable		 6f6jC-2b4eA:
22.48
6f6jD-2b4eA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d1l METASTASIS
SUPPRESSOR PROTEIN 1

(Mus musculus) 		PF08397
(IMD) 		4 GLN A 186
GLU A 129
HIS A 126
ALA A 187
 None
 1.49A 6f6jC-2d1lA:
undetectable
6f6jD-2d1lA:
undetectable		 6f6jC-2d1lA:
23.06
6f6jD-2d1lA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f28 SIALIDASE 2

(Homo sapiens) 		PF13088
(BNR_2) 		4 GLN A 256
GLU A 257
ALA A 246
GLN A 247
 None
 1.39A 6f6jC-2f28A:
undetectable
6f6jD-2f28A:
undetectable		 6f6jC-2f28A:
23.00
6f6jD-2f28A:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ge9 TYROSINE-PROTEIN
KINASE BTK

(Homo sapiens) 		PF00017
(SH2) 		4 GLN A  21
HIS A  64
ALA A  22
GLN A  24
 None
 1.13A 6f6jC-2ge9A:
undetectable
6f6jD-2ge9A:
undetectable		 6f6jC-2ge9A:
16.86
6f6jD-2ge9A:
16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ix8 ELONGATION FACTOR 3A

(Saccharomyces
cerevisiae) 		PF00005
(ABC_tran) 		4 GLN A1865
GLU A1859
HIS A1915
GLN A1912
 None
 1.12A 6f6jC-2ix8A:
undetectable
6f6jD-2ix8A:
undetectable		 6f6jC-2ix8A:
15.83
6f6jD-2ix8A:
15.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j16 TYROSINE-PROTEIN
PHOSPHATASE YIL113W

(Saccharomyces
cerevisiae) 		PF00782
(DSPc) 		4 GLN B 114
TRP B 109
ALA B 116
GLN B 186
 None
 1.22A 6f6jC-2j16B:
undetectable
6f6jD-2j16B:
undetectable		 6f6jC-2j16B:
21.56
6f6jD-2j16B:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jky HYPOXANTHINE-GUANINE
PHOSPHORIBOSYLTRANSF
ERASE

(Saccharomyces
cerevisiae) 		PF00156
(Pribosyltran) 		4 GLN A   7
HIS A 201
ALA A 205
GLN A 208
 None
 1.07A 6f6jC-2jkyA:
undetectable
6f6jD-2jkyA:
undetectable		 6f6jC-2jkyA:
19.95
6f6jD-2jkyA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ooe CLEAVAGE STIMULATION
FACTOR 77 KDA
SUBUNIT

(Mus musculus) 		PF05843
(Suf) 		4 GLN A 244
GLU A 245
TRP A 252
ALA A 234
 None
 1.16A 6f6jC-2ooeA:
undetectable
6f6jD-2ooeA:
undetectable		 6f6jC-2ooeA:
20.76
6f6jD-2ooeA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qry THIAMINE-BINDING
PERIPLASMIC PROTEIN

(Escherichia
coli) 		PF13343
(SBP_bac_6) 		4 GLN A 322
GLU A 320
TRP A 183
ALA A 324
 None
 0.98A 6f6jC-2qryA:
undetectable
6f6jD-2qryA:
undetectable		 6f6jC-2qryA:
21.96
6f6jD-2qryA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qvx 4-CHLOROBENZOATE COA
LIGASE

(Alcaligenes sp.
AL3007) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		4 GLN X  54
HIS X  75
ALA X 156
GLN X 154
 None
 1.21A 6f6jC-2qvxX:
undetectable
6f6jD-2qvxX:
undetectable		 6f6jC-2qvxX:
24.00
6f6jD-2qvxX:
24.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x24 ACETYL-COA
CARBOXYLASE

(Bos taurus) 		PF01039
(Carboxyl_trans) 		4 GLN A 708
TRP A 709
HIS A 713
ALA A 712
 None
 1.38A 6f6jC-2x24A:
undetectable
6f6jD-2x24A:
undetectable		 6f6jC-2x24A:
19.35
6f6jD-2x24A:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zm5 TRNA
DELTA(2)-ISOPENTENYL
PYROPHOSPHATE
TRANSFERASE

(Escherichia
coli) 		PF01715
(IPPT) 		4 GLN A 140
GLU A 143
ALA A 137
GLN A 136
 None
 1.28A 6f6jC-2zm5A:
undetectable
6f6jD-2zm5A:
undetectable		 6f6jC-2zm5A:
24.81
6f6jD-2zm5A:
24.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3act CELLOBIOSE
PHOSPHORYLASE

(Cellulomonas
gilvus) 		PF06165
(Glyco_transf_36)
PF17167
(Glyco_hydro_36) 		4 GLN A 342
GLU A 706
HIS A 703
ALA A 711
 None
 1.16A 6f6jC-3actA:
undetectable
6f6jD-3actA:
undetectable		 6f6jC-3actA:
18.76
6f6jD-3actA:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b2d CD180 ANTIGEN

(Homo sapiens) 		PF00560
(LRR_1)
PF13855
(LRR_8) 		4 GLN A 282
GLU A 256
HIS A 309
ALA A 307
 None
 1.16A 6f6jC-3b2dA:
undetectable
6f6jD-3b2dA:
undetectable		 6f6jC-3b2dA:
19.24
6f6jD-3b2dA:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dx5 UNCHARACTERIZED
PROTEIN ASBF

(Bacillus
anthracis) 		PF01261
(AP_endonuc_2) 		4 GLN A  88
GLU A  87
HIS A 135
ALA A  90
 None
 1.30A 6f6jC-3dx5A:
undetectable
6f6jD-3dx5A:
undetectable		 6f6jC-3dx5A:
22.42
6f6jD-3dx5A:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gnu 25 KDA PROTEIN
ELICITOR

(Pythium
aphanidermatum) 		PF05630
(NPP1) 		4 GLN P 178
GLU P  15
ALA P  22
GLN P  21
 None
 1.14A 6f6jC-3gnuP:
undetectable
6f6jD-3gnuP:
undetectable		 6f6jC-3gnuP:
19.72
6f6jD-3gnuP:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gue UTP-GLUCOSE-1-PHOSPH
ATE
URIDYLYLTRANSFERASE
2

(Trypanosoma
brucei) 		PF01704
(UDPGP) 		4 GLN A 282
GLU A 348
HIS A 190
ALA A 350
 None
GOL  A 490 (-3.6A)
UPG  A 484 (-3.7A)
UPG  A 484 ( 4.2A)
 1.34A 6f6jC-3gueA:
undetectable
6f6jD-3gueA:
undetectable		 6f6jC-3gueA:
22.22
6f6jD-3gueA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gwb PEPTIDASE M16
INACTIVE DOMAIN
FAMILY PROTEIN

(Pseudomonas
protegens) 		PF05193
(Peptidase_M16_C) 		4 GLU A 231
HIS A 163
ALA A 308
GLN A 307
 None
 0.83A 6f6jC-3gwbA:
undetectable
6f6jD-3gwbA:
undetectable		 6f6jC-3gwbA:
22.66
6f6jD-3gwbA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hr4 NITRIC OXIDE
SYNTHASE, INDUCIBLE

(Homo sapiens) 		PF00258
(Flavodoxin_1) 		4 GLN A 665
GLU A 658
TRP A 672
ALA A 668
 FMN  A 999 (-3.6A)
None
None
None
 1.47A 6f6jC-3hr4A:
undetectable
6f6jD-3hr4A:
undetectable		 6f6jC-3hr4A:
19.89
6f6jD-3hr4A:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3icl EAL/GGDEF DOMAIN
PROTEIN

(Methylococcus
capsulatus) 		PF00990
(GGDEF) 		4 GLU A  24
HIS A  23
ALA A  19
GLN A  18
 None
 1.37A 6f6jC-3iclA:
undetectable
6f6jD-3iclA:
undetectable		 6f6jC-3iclA:
19.06
6f6jD-3iclA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n0v FORMYLTETRAHYDROFOLA
TE DEFORMYLASE

(Pseudomonas
putida) 		PF00551
(Formyl_trans_N) 		4 GLN A 176
HIS A 142
ALA A 144
GLN A 153
 None
 1.23A 6f6jC-3n0vA:
undetectable
6f6jD-3n0vA:
undetectable		 6f6jC-3n0vA:
23.14
6f6jD-3n0vA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ndp ADENYLATE KINASE
ISOENZYME 4

(Homo sapiens) 		PF00406
(ADK)
PF05191
(ADK_lid) 		4 GLN A  23
HIS A 226
ALA A  26
GLN A  27
 None
 1.43A 6f6jC-3ndpA:
undetectable
6f6jD-3ndpA:
undetectable		 6f6jC-3ndpA:
20.44
6f6jD-3ndpA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p40 NEUROFASCIN

(Homo sapiens) 		PF13927
(Ig_3) 		4 GLN A  46
GLU A  62
HIS A  51
ALA A  48
 None
 1.17A 6f6jC-3p40A:
undetectable
6f6jD-3p40A:
undetectable		 6f6jC-3p40A:
21.55
6f6jD-3p40A:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pvt PHENYLACETIC ACID
DEGRADATION PROTEIN
PAAA

(Escherichia
coli) 		PF05138
(PaaA_PaaC) 		4 GLU A  72
HIS A 158
ALA A  67
GLN A  70
 None
 1.48A 6f6jC-3pvtA:
undetectable
6f6jD-3pvtA:
undetectable		 6f6jC-3pvtA:
22.02
6f6jD-3pvtA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3px2 N-METHYLTRANSFERASE

(Streptomyces
fradiae) 		PF13649
(Methyltransf_25) 		4 GLN A 219
GLU A 221
ALA A 223
GLN A 127
 None
 1.38A 6f6jC-3px2A:
undetectable
6f6jD-3px2A:
undetectable		 6f6jC-3px2A:
23.40
6f6jD-3px2A:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qde CELLOBIOSE
PHOSPHORYLASE

(Ruminiclostridium
thermocellum) 		PF06165
(Glyco_transf_36)
PF17167
(Glyco_hydro_36) 		4 GLN A 335
GLU A 693
HIS A 690
ALA A 698
 None
 1.14A 6f6jC-3qdeA:
undetectable
6f6jD-3qdeA:
undetectable		 6f6jC-3qdeA:
17.12
6f6jD-3qdeA:
17.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qdk RIBULOKINASE

(Bacillus
halodurans) 		PF00370
(FGGY_N)
PF02782
(FGGY_C) 		4 GLU A  56
TRP A  57
HIS A 128
ALA A  58
 None
 1.10A 6f6jC-3qdkA:
undetectable
6f6jD-3qdkA:
undetectable		 6f6jC-3qdkA:
23.47
6f6jD-3qdkA:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rko NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT N

(Escherichia
coli) 		no annotation 4 GLN N 439
GLU N 438
HIS N 435
ALA N 436
 None
 1.34A 6f6jC-3rkoN:
undetectable
6f6jD-3rkoN:
undetectable		 6f6jC-3rkoN:
23.20
6f6jD-3rkoN:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s6p CAPSID PROTEIN

(Helicoverpa
armigera stunt
virus) 		PF03566
(Peptidase_A21) 		4 GLN A 322
GLU A 321
ALA A 323
GLN A 309
 None
 1.28A 6f6jC-3s6pA:
undetectable
6f6jD-3s6pA:
undetectable		 6f6jC-3s6pA:
21.31
6f6jD-3s6pA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t6q CD180 ANTIGEN

(Mus musculus) 		PF13855
(LRR_8) 		4 GLN A 282
GLU A 256
HIS A 309
ALA A 307
 None
 1.13A 6f6jC-3t6qA:
undetectable
6f6jD-3t6qA:
undetectable		 6f6jC-3t6qA:
20.29
6f6jD-3t6qA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vea MACRODOMAIN TER
PROTEIN

(Yersinia pestis) 		no annotation 4 GLU B  69
TRP B  70
HIS B  74
ALA B  73
 None
 1.17A 6f6jC-3veaB:
undetectable
6f6jD-3veaB:
undetectable		 6f6jC-3veaB:
18.18
6f6jD-3veaB:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4acz ENDO-ALPHA-MANNOSIDA
SE

(Bacteroides
thetaiotaomicron) 		PF16317
(Glyco_hydro_99) 		4 GLN B 268
TRP B 269
HIS B 273
ALA B 272
 None
 1.40A 6f6jC-4aczB:
undetectable
6f6jD-4aczB:
undetectable		 6f6jC-4aczB:
19.36
6f6jD-4aczB:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bhk FLORICAULA/LEAFY
HOMOLOG 1

(Physcomitrella
patens) 		PF17538
(C_LFY_FLO) 		4 GLN A 299
GLU A 292
TRP A 297
ALA A 300
 None
 1.22A 6f6jC-4bhkA:
undetectable
6f6jD-4bhkA:
undetectable		 6f6jC-4bhkA:
19.32
6f6jD-4bhkA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bs2 TAR DNA-BINDING
PROTEIN 43

(Homo sapiens) 		PF00076
(RRM_1) 		4 GLN A 158
GLU A 154
HIS A  98
ALA A 100
 None
 1.27A 6f6jC-4bs2A:
undetectable
6f6jD-4bs2A:
undetectable		 6f6jC-4bs2A:
20.73
6f6jD-4bs2A:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cjm FIBROBLAST GROWTH
FACTOR 18

(Homo sapiens) 		PF00167
(FGF) 		4 GLU A  78
HIS A  65
ALA A  84
GLN A  85
 None
 1.47A 6f6jC-4cjmA:
undetectable
6f6jD-4cjmA:
undetectable		 6f6jC-4cjmA:
15.13
6f6jD-4cjmA:
15.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cmr GLYCOSYL
HYDROLASE/DEACETYLAS
E FAMILY PROTEIN

(Pyrococcus sp.
ST04) 		no annotation 4 GLU A  80
TRP A 150
HIS A  10
ALA A  11
 None
 1.45A 6f6jC-4cmrA:
undetectable
6f6jD-4cmrA:
undetectable		 6f6jC-4cmrA:
20.57
6f6jD-4cmrA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ddw REVERSE GYRASE

(Thermotoga
maritima) 		PF00270
(DEAD)
PF01131
(Topoisom_bac)
PF01751
(Toprim) 		4 GLN A 864
GLU A 862
ALA A 867
GLN A 936
 None
 1.47A 6f6jC-4ddwA:
undetectable
6f6jD-4ddwA:
undetectable		 6f6jC-4ddwA:
16.79
6f6jD-4ddwA:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4exj UNCHARACTERIZED
PROTEIN

(Lodderomyces
elongisporus) 		PF00043
(GST_C)
PF13417
(GST_N_3) 		4 GLU A 216
HIS A  32
ALA A 214
GLN A 221
 None
 1.29A 6f6jC-4exjA:
undetectable
6f6jD-4exjA:
undetectable		 6f6jC-4exjA:
19.79
6f6jD-4exjA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h3s GLUTAMINE-TRNA
LIGASE

(Saccharomyces
cerevisiae) 		PF00749
(tRNA-synt_1c)
PF03950
(tRNA-synt_1c_C)
PF04557
(tRNA_synt_1c_R2) 		4 GLN A 235
GLU A 232
HIS A 455
ALA A 482
 None
None
ACT  A 913 (-4.3A)
None
 1.10A 6f6jC-4h3sA:
undetectable
6f6jD-4h3sA:
undetectable		 6f6jC-4h3sA:
17.39
6f6jD-4h3sA:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i6n UBIQUITIN
CARBOXYL-HYDROLASE

(Trichinella
spiralis) 		PF01088
(Peptidase_C12) 		4 GLN A  79
TRP A   6
HIS A 137
GLN A  88
 None
 1.37A 6f6jC-4i6nA:
undetectable
6f6jD-4i6nA:
undetectable		 6f6jC-4i6nA:
20.92
6f6jD-4i6nA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4idm DELTA-1-PYRROLINE-5-
CARBOXYLATE
DEHYDROGENASE

(Mycobacterium
tuberculosis) 		PF00171
(Aldedh) 		4 GLN A 466
GLU A 442
HIS A 303
ALA A 467
 None
 1.44A 6f6jC-4idmA:
undetectable
6f6jD-4idmA:
undetectable		 6f6jC-4idmA:
22.36
6f6jD-4idmA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ig7 UBIQUITIN C-TERMINAL
HYDROLASE 37

(Trichinella
spiralis) 		PF01088
(Peptidase_C12) 		4 GLN A  79
TRP A   6
HIS A 137
GLN A  88
 None
 1.39A 6f6jC-4ig7A:
undetectable
6f6jD-4ig7A:
undetectable		 6f6jC-4ig7A:
22.73
6f6jD-4ig7A:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4obt TRIOSEPHOSPHATE
ISOMERASE, CYTOSOLIC

(Arabidopsis
thaliana) 		PF00121
(TIM) 		4 GLN A 183
GLU A 184
ALA A 182
GLN A 224
 None
 1.38A 6f6jC-4obtA:
undetectable
6f6jD-4obtA:
undetectable		 6f6jC-4obtA:
22.37
6f6jD-4obtA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oli NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 GLN A 946
GLU A 947
HIS A1021
ALA A1045
 None
 1.43A 6f6jC-4oliA:
undetectable
6f6jD-4oliA:
undetectable		 6f6jC-4oliA:
20.46
6f6jD-4oliA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pfr TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT

(Rhodobacter
sphaeroides) 		PF03480
(DctP) 		4 GLU A  34
HIS A  30
ALA A  42
GLN A  46
 None
 1.41A 6f6jC-4pfrA:
undetectable
6f6jD-4pfrA:
undetectable		 6f6jC-4pfrA:
23.59
6f6jD-4pfrA:
23.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ph0 BLV CAPSID

(Bovine leukemia
virus) 		PF00607
(Gag_p24) 		4 GLN A 119
TRP A 117
HIS A  70
ALA A 120
 None
 1.25A 6f6jC-4ph0A:
undetectable
6f6jD-4ph0A:
undetectable		 6f6jC-4ph0A:
21.37
6f6jD-4ph0A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ph3 BLV CAPSID

(Bovine leukemia
virus) 		PF00607
(Gag_p24) 		4 GLN A 119
TRP A 117
HIS A  70
ALA A 120
 IOD  A 219 (-3.8A)
CSO  A  58 ( 4.8A)
None
None
 1.13A 6f6jC-4ph3A:
undetectable
6f6jD-4ph3A:
undetectable		 6f6jC-4ph3A:
14.74
6f6jD-4ph3A:
14.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qan HYPOTHETICAL PROTEIN

([Ruminococcus]
gnavus) 		no annotation 4 GLN A 193
GLU A  84
ALA A 168
GLN A 169
 None
 1.29A 6f6jC-4qanA:
undetectable
6f6jD-4qanA:
undetectable		 6f6jC-4qanA:
23.20
6f6jD-4qanA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qpp PROTEIN ARGININE
N-METHYLTRANSFERASE
6

(Homo sapiens) 		PF13649
(Methyltransf_25) 		4 GLU A 112
TRP A 117
ALA A 120
GLN A 119
 SAH  A1000 (-2.7A)
None
None
None
 1.32A 6f6jC-4qppA:
undetectable
6f6jD-4qppA:
undetectable		 6f6jC-4qppA:
22.95
6f6jD-4qppA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qxa RAS-RELATED PROTEIN
RAB-9A

(Mus musculus) 		PF00071
(Ras) 		4 GLN A 139
GLU A 137
TRP A 141
ALA A 140
 None
 1.38A 6f6jC-4qxaA:
undetectable
6f6jD-4qxaA:
undetectable		 6f6jC-4qxaA:
18.90
6f6jD-4qxaA:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4s3p 4-ALPHA-GLUCANOTRANS
FERASE

(Escherichia
coli) 		PF02446
(Glyco_hydro_77) 		4 GLU A 227
TRP A 231
ALA A 230
GLN A 229
 None
 1.41A 6f6jC-4s3pA:
undetectable
6f6jD-4s3pA:
undetectable		 6f6jC-4s3pA:
19.31
6f6jD-4s3pA:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wa8 FLAP ENDONUCLEASE 1

(Methanopyrus
kandleri) 		PF00752
(XPG_N)
PF00867
(XPG_I) 		4 GLN A 169
GLU A 151
ALA A  32
GLN A  35
 None
 1.25A 6f6jC-4wa8A:
undetectable
6f6jD-4wa8A:
undetectable		 6f6jC-4wa8A:
20.21
6f6jD-4wa8A:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wd1 ACETOACETATE-COA
LIGASE

(Streptomyces
lividans) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C)
PF16177
(ACAS_N) 		4 GLU A 115
HIS A 117
ALA A 347
GLN A 348
 None
 1.30A 6f6jC-4wd1A:
undetectable
6f6jD-4wd1A:
undetectable		 6f6jC-4wd1A:
20.75
6f6jD-4wd1A:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wjb PUTATIVE
AMIDOHYDROLASE/PEPTI
DASE

(Burkholderia
cenocepacia) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		4 GLU A 197
HIS A 363
ALA A 361
GLN A 216
 None
None
SO4  A 503 ( 4.9A)
None
 1.47A 6f6jC-4wjbA:
undetectable
6f6jD-4wjbA:
undetectable		 6f6jC-4wjbA:
23.57
6f6jD-4wjbA:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wlp UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE ISOZYME L5

(Homo sapiens) 		PF01088
(Peptidase_C12) 		4 GLN A  82
TRP A   8
HIS A 140
GLN A  91
 None
 1.42A 6f6jC-4wlpA:
undetectable
6f6jD-4wlpA:
undetectable		 6f6jC-4wlpA:
22.75
6f6jD-4wlpA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xkz VALINE-TRNA LIGASE

(Pseudomonas
aeruginosa) 		PF08264
(Anticodon_1) 		4 GLN A 699
GLU A 703
TRP A 706
ALA A 631
 None
 1.35A 6f6jC-4xkzA:
undetectable
6f6jD-4xkzA:
undetectable		 6f6jC-4xkzA:
19.20
6f6jD-4xkzA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xyw O-ANTIGEN
BIOSYNTHESIS
GLYCOSYLTRANSFERASE
WBNH

(Escherichia
coli) 		PF00534
(Glycos_transf_1)
PF13439
(Glyco_transf_4) 		4 GLN A 315
GLU A 285
HIS A 266
ALA A 319
 None
 1.01A 6f6jC-4xywA:
undetectable
6f6jD-4xywA:
undetectable		 6f6jC-4xywA:
20.88
6f6jD-4xywA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y96 TRIOSEPHOSPHATE
ISOMERASE

(Gemmata
obscuriglobus) 		PF00121
(TIM) 		4 GLN A 188
GLU A 189
ALA A 187
GLN A 229
 None
 1.40A 6f6jC-4y96A:
undetectable
6f6jD-4y96A:
undetectable		 6f6jC-4y96A:
23.93
6f6jD-4y96A:
23.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dql ISOCITRATE LYASE 1

(Mycobacterium
tuberculosis) 		PF00463
(ICL) 		4 GLN A 333
GLU A 335
ALA A 337
GLN A 344
 None
 1.13A 6f6jC-5dqlA:
undetectable
6f6jD-5dqlA:
undetectable		 6f6jC-5dqlA:
25.33
6f6jD-5dqlA:
25.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eue PUTATIVE
SPHINGOSINE-1-PHOSPH
ATE LYASE

(Symbiobacterium
thermophilum) 		PF00282
(Pyridoxal_deC) 		4 GLU A 140
TRP A 363
ALA A 360
GLN A 122
 None
 1.41A 6f6jC-5eueA:
undetectable
6f6jD-5eueA:
undetectable		 6f6jC-5eueA:
22.35
6f6jD-5eueA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ezj FAB C12 HEAVY CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 GLN A  59
GLU A  60
ALA A  54
GLN A  53
 None
 1.42A 6f6jC-5ezjA:
undetectable
6f6jD-5ezjA:
undetectable		 6f6jC-5ezjA:
19.61
6f6jD-5ezjA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j9g GLYCERALDEHYDE-3-P
DEHYDROGENASE

(Lactobacillus
acidophilus) 		PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C) 		4 GLN A  83
HIS A 114
ALA A  84
GLN A  85
 None
 1.49A 6f6jC-5j9gA:
undetectable
6f6jD-5j9gA:
undetectable		 6f6jC-5j9gA:
21.43
6f6jD-5j9gA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lta PRE-MRNA-SPLICING
FACTOR ATP-DEPENDENT
RNA HELICASE PRP43

(Chaetomium
thermophilum) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF04408
(HA2)
PF07717
(OB_NTP_bind) 		4 GLU A 385
HIS A 221
ALA A 424
GLN A 427
 None
 1.27A 6f6jC-5ltaA:
undetectable
6f6jD-5ltaA:
undetectable		 6f6jC-5ltaA:
19.69
6f6jD-5ltaA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n8o DNA HELICASE I

(Escherichia
coli) 		PF07057
(TraI)
PF08751
(TrwC)
PF13604
(AAA_30) 		4 GLN A 973
GLU A 967
ALA A1004
GLN A1001
 None
 1.23A 6f6jC-5n8oA:
undetectable
6f6jD-5n8oA:
undetectable		 6f6jC-5n8oA:
12.35
6f6jD-5n8oA:
12.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nzg UDP-GLUCOSE
PYROPHOSPHORYLASE

(Leishmania
major) 		no annotation 4 GLN A 287
GLU A 353
HIS A 191
ALA A 355
 None
None
UPG  A 601 (-3.8A)
UPG  A 601 ( 4.2A)
 1.42A 6f6jC-5nzgA:
undetectable
6f6jD-5nzgA:
undetectable		 6f6jC-5nzgA:
undetectable
6f6jD-5nzgA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5opf CHITIN-BINDING
DOMAIN 3 PROTEIN

(Micromonospora
aurantiaca) 		no annotation 4 GLU A  90
HIS A 216
ALA A 214
GLN A 213
 None
 1.22A 6f6jC-5opfA:
undetectable
6f6jD-5opfA:
undetectable		 6f6jC-5opfA:
undetectable
6f6jD-5opfA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tz8 GLYCOSYL TRANSFERASE

(Staphylococcus
aureus) 		PF00535
(Glycos_transf_2) 		4 GLN A 283
GLU A 287
HIS A 302
ALA A 306
 None
 1.33A 6f6jC-5tz8A:
undetectable
6f6jD-5tz8A:
undetectable		 6f6jC-5tz8A:
21.06
6f6jD-5tz8A:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tzk GLYCOSYL TRANSFERASE

(Staphylococcus
aureus) 		PF00535
(Glycos_transf_2) 		4 GLN C 283
GLU C 287
HIS C 302
ALA C 306
 None
 1.31A 6f6jC-5tzkC:
undetectable
6f6jD-5tzkC:
undetectable		 6f6jC-5tzkC:
23.19
6f6jD-5tzkC:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u02 GLYCOSYL TRANSFERASE

(Staphylococcus
aureus) 		no annotation 4 GLN A 283
GLU A 287
HIS A 302
ALA A 306
 None
 1.38A 6f6jC-5u02A:
undetectable
6f6jD-5u02A:
undetectable		 6f6jC-5u02A:
21.58
6f6jD-5u02A:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yh3 EXTRACELLULAR
SERINE/THREONINE
PROTEIN KINASE
FAM20C

(Homo sapiens) 		no annotation 4 GLN C 293
GLU C 294
HIS C 542
GLN C 289
 None
 1.42A 6f6jC-5yh3C:
undetectable
6f6jD-5yh3C:
undetectable		 6f6jC-5yh3C:
undetectable
6f6jD-5yh3C:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yp3 DIPEPTIDYL
AMINOPEPTIDASE 4

(Pseudoxanthomonas
mexicana) 		no annotation 4 GLU A 456
HIS A 431
ALA A 427
GLN A 426
 None
 1.42A 6f6jC-5yp3A:
undetectable
6f6jD-5yp3A:
undetectable		 6f6jC-5yp3A:
undetectable
6f6jD-5yp3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cxd PEPTIDASE B

(Yersinia pestis) 		no annotation 4 GLN A 355
GLU A 350
HIS A 384
ALA A 380
 None
None
SO4  A 502 (-3.7A)
None
 1.38A 6f6jC-6cxdA:
undetectable
6f6jD-6cxdA:
undetectable		 6f6jC-6cxdA:
undetectable
6f6jD-6cxdA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d43 TRIOSEPHOSPHATE
ISOMERASE

(Homo sapiens) 		no annotation 4 GLN B 182
GLU B 183
ALA B 181
GLN B 223
 None
 1.27A 6f6jC-6d43B:
undetectable
6f6jD-6d43B:
undetectable		 6f6jC-6d43B:
undetectable
6f6jD-6d43B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f0k FE-S-CLUSTER-CONTAIN
ING HYDROGENASE

(Rhodothermus
marinus) 		no annotation 4 GLU B 491
TRP B 166
HIS B 494
ALA B 493
 None
 1.25A 6f6jC-6f0kB:
undetectable
6f6jD-6f0kB:
undetectable		 6f6jC-6f0kB:
undetectable
6f6jD-6f0kB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fv5 QUEUINE
TRNA-RIBOSYLTRANSFER
ASE ACCESSORY
SUBUNIT 2

(Mus musculus) 		no annotation 4 GLN A 137
GLU A 134
HIS A  71
ALA A  75
 None
 1.24A 6f6jC-6fv5A:
undetectable
6f6jD-6fv5A:
undetectable		 6f6jC-6fv5A:
undetectable
6f6jD-6fv5A:
undetectable