SIMILAR PATTERNS OF AMINO ACIDS FOR 6F6J_A_ACTA404_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bx0 PROTEIN
(FERREDOXIN:NADP+
OXIDOREDUCTASE)

(Spinacia
oleracea) 		PF00175
(NAD_binding_1) 		4 ILE A  97
TYR A  70
ARG A 178
SER A 179
 None
 1.24A 6f6jA-1bx0A:
0.0		 6f6jA-1bx0A:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f20 NITRIC-OXIDE
SYNTHASE

(Rattus
norvegicus) 		PF00175
(NAD_binding_1)
PF00667
(FAD_binding_1) 		4 ILE A1177
TYR A1027
ARG A1257
SER A1258
 None
 1.23A 6f6jA-1f20A:
0.0		 6f6jA-1f20A:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fob BETA-1,4-GALACTANASE

(Aspergillus
aculeatus) 		PF07745
(Glyco_hydro_53) 		4 ILE A  44
LEU A  12
VAL A  69
ARG A  68
 None
 1.17A 6f6jA-1fobA:
0.0		 6f6jA-1fobA:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gyd ARABINAN
ENDO-1,5-ALPHA-L-ARA
BINOSIDASE A

(Cellvibrio
japonicus) 		PF04616
(Glyco_hydro_43) 		4 ILE B 225
TYR B 263
LEU B 182
SER B 172
 None
 1.26A 6f6jA-1gydB:
0.0		 6f6jA-1gydB:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jne IMAGINAL DISC GROWTH
FACTOR-2

(Drosophila
melanogaster) 		PF00704
(Glyco_hydro_18) 		4 ILE A  59
TYR A 122
LEU A 118
SER A  52
 None
 0.98A 6f6jA-1jneA:
0.0		 6f6jA-1jneA:
23.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ktr ANTI-HIS TAG
ANTIBODY 3D5
VARIABLE LIGHT
CHAIN, PEPTIDE
LINKER, ANTI-HIS TAG
ANTIBODY 3D5
VARIABLE HEAVY CHAIN

(Mus musculus) 		PF07686
(V-set) 		4 ILE L  93
TYR L 104
LEU L  11
VAL L  96
 None
 1.16A 6f6jA-1ktrL:
0.1		 6f6jA-1ktrL:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lbk GLUTATHIONE
S-TRANSFERASE CLASS
PI CHIMAERA (CODA)

(Homo sapiens) 		PF02798
(GST_N)
PF14497
(GST_C_3) 		4 ILE A 143
TYR A 179
VAL A  92
SER A 149
 None
 1.21A 6f6jA-1lbkA:
0.0		 6f6jA-1lbkA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n60 CARBON MONOXIDE
DEHYDROGENASE LARGE
CHAIN

(Oligotropha
carboxidovorans) 		PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2) 		4 ILE B 478
TYR B 781
LEU B 807
ARG B 476
 None
 1.23A 6f6jA-1n60B:
0.0		 6f6jA-1n60B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nhw ENOYL-ACYL CARRIER
REDUCTASE
ENOYL-ACYL CARRIER
REDUCTASE

(Plasmodium
falciparum;
Plasmodium
falciparum) 		PF13561
(adh_short_C2)
PF13561
(adh_short_C2) 		4 ILE C 391
TYR A 111
LEU A 265
VAL C 413
 None
NAD  A 450 (-4.6A)
NAD  A 450 (-3.7A)
None
 1.25A 6f6jA-1nhwC:
undetectable		 6f6jA-1nhwC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o0s NAD-DEPENDENT MALIC
ENZYME

(Ascaris suum) 		PF00390
(malic)
PF03949
(Malic_M) 		4 ILE A 195
TYR A 126
LEU A 183
ARG A 181
 None
None
NAI  A 920 (-4.7A)
NAI  A 920 (-2.9A)
 1.14A 6f6jA-1o0sA:
undetectable		 6f6jA-1o0sA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pl0 BIFUNCTIONAL PURINE
BIOSYNTHESIS PROTEIN
PURH

(Homo sapiens) 		PF01808
(AICARFT_IMPCHas)
PF02142
(MGS) 		4 ILE A 341
TYR A 362
VAL A 319
ARG A 307
 None
 0.96A 6f6jA-1pl0A:
undetectable		 6f6jA-1pl0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rdr POLIOVIRUS 3D
POLYMERASE

(Enterovirus C) 		PF00680
(RdRP_1) 		4 ILE A 316
TYR A 334
LEU A 321
ARG A 306
 None
 0.97A 6f6jA-1rdrA:
undetectable		 6f6jA-1rdrA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sxj ACTIVATOR 1 41 KDA
SUBUNIT

(Saccharomyces
cerevisiae) 		PF00004
(AAA)
PF08542
(Rep_fac_C) 		4 ILE D 350
TYR D 308
LEU D 304
VAL D 275
 None
 1.19A 6f6jA-1sxjD:
undetectable		 6f6jA-1sxjD:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t9k PROBABLE
METHYLTHIORIBOSE-1-P
HOSPHATE ISOMERASE

(Thermotoga
maritima) 		PF01008
(IF-2B) 		4 ILE A 181
LEU A 202
VAL A 175
ARG A 172
 None
 1.21A 6f6jA-1t9kA:
undetectable		 6f6jA-1t9kA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tll NITRIC-OXIDE
SYNTHASE, BRAIN

(Rattus
norvegicus) 		PF00175
(NAD_binding_1)
PF00258
(Flavodoxin_1)
PF00667
(FAD_binding_1) 		4 ILE A1177
TYR A1027
ARG A1257
SER A1258
 None
 1.27A 6f6jA-1tllA:
undetectable		 6f6jA-1tllA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1umi F-BOX ONLY PROTEIN 2

(Mus musculus) 		PF04300
(FBA) 		4 ILE A 205
TYR A 261
LEU A 198
VAL A 295
 None
 0.91A 6f6jA-1umiA:
undetectable		 6f6jA-1umiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ut4 NO APICAL MERISTEM
PROTEIN

(Arabidopsis
thaliana) 		PF02365
(NAM) 		4 ILE A  46
TYR A  31
LEU A  27
ARG A 158
 None
 1.26A 6f6jA-1ut4A:
undetectable		 6f6jA-1ut4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wl7 ARABINANASE-TS

(Geobacillus
thermodenitrificans) 		PF04616
(Glyco_hydro_43) 		4 ILE A 205
LEU A 171
VAL A 151
SER A 161
 None
 1.30A 6f6jA-1wl7A:
undetectable		 6f6jA-1wl7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wt5 ANTI EGFR ANTIBODY
FV REGION

(Homo sapiens) 		PF07686
(V-set) 		4 ILE C  80
TYR C  91
LEU C  11
VAL C  83
 None
 1.09A 6f6jA-1wt5C:
undetectable		 6f6jA-1wt5C:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xhb POLYPEPTIDE
N-ACETYLGALACTOSAMIN
YLTRANSFERASE 1

(Mus musculus) 		PF00535
(Glycos_transf_2)
PF00652
(Ricin_B_lectin) 		4 ILE A 537
LEU A 488
VAL A 485
SER A 520
 None
 0.99A 6f6jA-1xhbA:
undetectable		 6f6jA-1xhbA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xje RIBONUCLEOTIDE
REDUCTASE,
B12-DEPENDENT

(Thermotoga
maritima) 		PF00317
(Ribonuc_red_lgN)
PF02867
(Ribonuc_red_lgC) 		4 ILE A 286
TYR A 614
LEU A 611
ARG A 284
 None
 1.18A 6f6jA-1xjeA:
undetectable		 6f6jA-1xjeA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xn7 HYPOTHETICAL PROTEIN
YHGG

(Escherichia
coli) 		PF09012
(FeoC) 		4 ILE A  33
LEU A  40
VAL A   7
ARG A   8
 None
 1.28A 6f6jA-1xn7A:
undetectable		 6f6jA-1xn7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yvl SIGNAL TRANSDUCER
AND ACTIVATOR OF
TRANSCRIPTION
1-ALPHA/BETA

(Homo sapiens) 		PF00017
(SH2)
PF01017
(STAT_alpha)
PF02864
(STAT_bind)
PF02865
(STAT_int) 		4 ILE A 160
LEU A 283
VAL A 213
ARG A 210
 None
 1.13A 6f6jA-1yvlA:
undetectable		 6f6jA-1yvlA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z5x ECDYSONE RECEPTOR
LIGAND BINDING
DOMAIN

(Bemisia tabaci) 		PF00104
(Hormone_recep) 		4 ILE E 238
LEU E 260
VAL E 267
SER E 242
 None
 1.19A 6f6jA-1z5xE:
undetectable		 6f6jA-1z5xE:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bka TAT-INTERACTING
PROTEIN TIP30

(Homo sapiens) 		PF13460
(NAD_binding_10) 		4 ILE A  50
LEU A 118
VAL A  70
SER A 115
 None
 1.22A 6f6jA-2bkaA:
undetectable		 6f6jA-2bkaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cwo RNA SILENCING
SUPPRESSOR

(Beet yellows
virus) 		PF11479
(Suppressor_P21) 		4 ILE A  78
LEU A  46
ARG A  16
SER A  17
 None
 0.89A 6f6jA-2cwoA:
undetectable		 6f6jA-2cwoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e32 F-BOX ONLY PROTEIN 2

(Mus musculus) 		PF00646
(F-box)
PF04300
(FBA) 		4 ILE A 205
TYR A 261
LEU A 198
VAL A 295
 None
 0.78A 6f6jA-2e32A:
undetectable		 6f6jA-2e32A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nr4 CONSERVED
HYPOTHETICAL PROTEIN

(Methanosarcina
mazei) 		PF04289
(DUF447) 		4 ILE A  33
LEU A  94
ARG A  88
SER A  89
 None
 1.06A 6f6jA-2nr4A:
undetectable		 6f6jA-2nr4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uw1 PLASTID DELTA4
MULTIFUNCTIONAL
ACYL-ACYL CARRIER
PROTEIN DESATURASE

(Hedera helix) 		PF03405
(FA_desaturase_2) 		4 ILE B 185
LEU B 299
VAL B 235
SER B 188
 None
 1.28A 6f6jA-2uw1B:
undetectable		 6f6jA-2uw1B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vdc GLUTAMATE SYNTHASE
[NADPH] LARGE CHAIN

(Azospirillum
brasilense) 		PF00310
(GATase_2)
PF01493
(GXGXG)
PF01645
(Glu_synthase)
PF04898
(Glu_syn_central) 		4 ILE A 177
TYR A 179
VAL A  73
SER A 171
 None
 1.27A 6f6jA-2vdcA:
undetectable		 6f6jA-2vdcA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wsu PUTATIVE FIBER
PROTEIN

(Porcine
mastadenovirus
B) 		PF00337
(Gal-bind_lectin) 		4 ILE A 482
TYR A 487
LEU A 425
VAL A 402
 None
 0.96A 6f6jA-2wsuA:
undetectable		 6f6jA-2wsuA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xxm CAMELID VHH 9

(Vicugna pacos) 		PF07686
(V-set) 		4 ILE B  48
TYR B  90
LEU B  80
VAL B  63
 None
 1.29A 6f6jA-2xxmB:
undetectable		 6f6jA-2xxmB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y2w ARABINOFURANOSIDASE

(Bifidobacterium
longum) 		PF06964
(Alpha-L-AF_C) 		4 ILE A 393
LEU A 391
VAL A 484
SER A 307
 None
 1.27A 6f6jA-2y2wA:
undetectable		 6f6jA-2y2wA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cqg NUCLEAR PORE COMPLEX
PROTEIN NUP107

(Homo sapiens) 		PF04121
(Nup84_Nup100) 		4 ILE A 744
TYR A 724
LEU A 736
ARG A 833
 None
 1.24A 6f6jA-3cqgA:
undetectable		 6f6jA-3cqgA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dra PROTEIN
FARNESYLTRANSFERASE/
GERANYLGERANYLTRANSF
ERASE TYPE-1 SUBUNIT
ALPHA

(Candida
albicans) 		PF01239
(PPTA) 		4 ILE A  76
TYR A  72
LEU A  42
ARG A  51
 None
 1.20A 6f6jA-3draA:
undetectable		 6f6jA-3draA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dx5 UNCHARACTERIZED
PROTEIN ASBF

(Bacillus
anthracis) 		PF01261
(AP_endonuc_2) 		4 ILE A 125
LEU A 148
VAL A 162
ARG A 118
 None
None
None
TRS  A 290 (-4.2A)
 1.29A 6f6jA-3dx5A:
undetectable		 6f6jA-3dx5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3er6 PUTATIVE
TRANSCRIPTIONAL
REGULATOR PROTEIN

(Vibrio
parahaemolyticus) 		PF01965
(DJ-1_PfpI) 		4 ILE A  79
LEU A  31
VAL A 112
SER A  27
 None
 1.27A 6f6jA-3er6A:
undetectable		 6f6jA-3er6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fwt MACROPHAGE MIGRATION
INHIBITORY
FACTOR-LIKE PROTEIN

(Leishmania
major) 		PF01187
(MIF) 		4 ILE A  80
TYR A  23
LEU A   3
VAL A  97
 None
 1.29A 6f6jA-3fwtA:
undetectable		 6f6jA-3fwtA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hzh CHEMOTAXIS RESPONSE
REGULATOR (CHEY-3)

(Borreliella
burgdorferi) 		PF00072
(Response_reg) 		4 ILE A  94
TYR A  66
LEU A  29
VAL A 103
 None
 1.21A 6f6jA-3hzhA:
undetectable		 6f6jA-3hzhA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iy1 FAB B, LIGHT CHAIN

(Rattus
norvegicus) 		PF07686
(V-set) 		4 ILE A  73
TYR A  84
LEU A   9
VAL A  76
 None
 1.15A 6f6jA-3iy1A:
undetectable		 6f6jA-3iy1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lom GERANYLTRANSTRANSFER
ASE

(Legionella
pneumophila) 		PF00348
(polyprenyl_synt) 		4 ILE A 274
LEU A 237
ARG A 305
SER A 306
 None
 1.30A 6f6jA-3lomA:
undetectable		 6f6jA-3lomA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m4x NOL1/NOP2/SUN FAMILY
PROTEIN

(Enterococcus
faecium) 		PF01189
(Methyltr_RsmB-F)
PF13636
(Methyltranf_PUA)
PF17125
(Methyltr_RsmF_N)
PF17126
(RsmF_methylt_CI) 		4 ILE A 150
LEU A 133
VAL A 160
SER A 120
 None
 1.27A 6f6jA-3m4xA:
undetectable		 6f6jA-3m4xA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mhp FERREDOXIN--NADP
REDUCTASE, LEAF
ISOZYME,
CHLOROPLASTIC

(Pisum sativum) 		PF00175
(NAD_binding_1) 		4 ILE A  91
TYR A  64
ARG A 172
SER A 173
 None
 1.24A 6f6jA-3mhpA:
undetectable		 6f6jA-3mhpA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3owa ACYL-COA
DEHYDROGENASE

(Bacillus
anthracis) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		4 ILE A 199
TYR A 175
LEU A 247
SER A 205
 None
 1.10A 6f6jA-3owaA:
undetectable		 6f6jA-3owaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pc3 CG1753, ISOFORM A

(Drosophila
melanogaster) 		PF00291
(PALP)
PF00571
(CBS) 		4 ILE A 230
LEU A 256
VAL A 289
ARG A 258
 None
 1.20A 6f6jA-3pc3A:
undetectable		 6f6jA-3pc3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q3h HMW1C-LIKE
GLYCOSYLTRANSFERASE

(Actinobacillus
pleuropneumoniae) 		no annotation 4 ILE A 433
LEU A 486
VAL A 461
ARG A 454
 None
 1.29A 6f6jA-3q3hA:
undetectable		 6f6jA-3q3hA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qgh RNA-DIRECTED RNA
POLYMERASE

(Hepacivirus C) 		PF00998
(RdRP_3) 		4 ILE A 119
TYR A 103
LEU A 165
ARG A 168
 None
 1.28A 6f6jA-3qghA:
undetectable		 6f6jA-3qghA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rku OXIDOREDUCTASE
YMR226C

(Saccharomyces
cerevisiae) 		PF00106
(adh_short) 		4 ILE A 236
TYR A  33
VAL A 151
ARG A 192
 None
 1.23A 6f6jA-3rkuA:
undetectable		 6f6jA-3rkuA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ty6 ATP-DEPENDENT
PROTEASE SUBUNIT
HSLV

(Bacillus
anthracis) 		PF00227
(Proteasome) 		4 ILE A 126
LEU A 143
VAL A  12
SER A 160
 None
 1.13A 6f6jA-3ty6A:
undetectable		 6f6jA-3ty6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ui7 CAMP AND
CAMP-INHIBITED CGMP
3',5'-CYCLIC
PHOSPHODIESTERASE
10A

(Homo sapiens) 		PF00233
(PDEase_I) 		4 ILE A 744
LEU A 547
VAL A 665
ARG A 662
 None
 0.98A 6f6jA-3ui7A:
undetectable		 6f6jA-3ui7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vo2 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Zea mays) 		PF00175
(NAD_binding_1) 		4 ILE A  97
TYR A  70
ARG A 178
SER A 179
 None
 1.23A 6f6jA-3vo2A:
undetectable		 6f6jA-3vo2A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vrb FLAVOPROTEIN SUBUNIT
OF COMPLEX II

(Ascaris suum) 		PF00890
(FAD_binding_2)
PF02910
(Succ_DH_flav_C) 		4 ILE A 287
LEU A 360
ARG A 151
SER A 291
 None
 0.93A 6f6jA-3vrbA:
undetectable		 6f6jA-3vrbA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w5v FERREDOXIN

(Zea mays) 		PF00175
(NAD_binding_1)
PF00970
(FAD_binding_6) 		4 ILE A  97
TYR A  70
ARG A 178
SER A 179
 None
 1.20A 6f6jA-3w5vA:
undetectable		 6f6jA-3w5vA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a5w COMPLEMENT C5

(Homo sapiens) 		PF00207
(A2M)
PF01759
(NTR)
PF01835
(A2M_N)
PF07677
(A2M_recep)
PF07678
(A2M_comp)
PF07703
(A2M_N_2) 		4 ILE A1264
TYR A1300
VAL A 984
ARG A1308
 None
 1.15A 6f6jA-4a5wA:
undetectable		 6f6jA-4a5wA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bf5 ALANINE RACEMASE

(Aeromonas
hydrophila) 		PF00842
(Ala_racemase_C)
PF01168
(Ala_racemase_N) 		4 ILE A 351
TYR A 323
LEU A 369
VAL A 342
 None
CL  A1419 ( 4.5A)
None
None
 1.24A 6f6jA-4bf5A:
undetectable		 6f6jA-4bf5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bf7 ARABINOGALACTAN
ENDO-1,4-BETA-GALACT
OSIDASE A

(Aspergillus
nidulans) 		PF07745
(Glyco_hydro_53) 		4 ILE A  44
LEU A  12
VAL A  69
ARG A  68
 None
None
None
ACT  A1337 ( 3.8A)
 1.21A 6f6jA-4bf7A:
undetectable		 6f6jA-4bf7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fod ALK TYROSINE KINASE
RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 ILE A1322
LEU A1221
VAL A1229
ARG A1264
 None
 1.09A 6f6jA-4fodA:
undetectable		 6f6jA-4fodA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ft6 PROBABLE PORIN

(Pseudomonas
aeruginosa) 		PF03573
(OprD) 		4 ILE A 203
LEU A 242
VAL A 166
ARG A 169
 None
 1.29A 6f6jA-4ft6A:
undetectable		 6f6jA-4ft6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g3h ARGINASE (ROCF)

(Helicobacter
pylori) 		PF00491
(Arginase) 		4 ILE A  71
LEU A 167
ARG A 102
SER A 103
 None
 1.28A 6f6jA-4g3hA:
undetectable		 6f6jA-4g3hA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gsl AUTOPHAGY-RELATED
PROTEIN 3

(Saccharomyces
cerevisiae) 		PF03986
(Autophagy_N)
PF03987
(Autophagy_act_C)
PF10381
(Autophagy_C) 		4 ILE C 186
TYR C 169
VAL C 229
ARG C 210
 None
 1.24A 6f6jA-4gslC:
undetectable		 6f6jA-4gslC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4il1 CALMODULIN,
CALCINEURIN SUBUNIT
B TYPE 1,
SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2B
CATALYTIC SUBUNIT
ALPHA ISOFORM

(Rattus
norvegicus) 		PF00149
(Metallophos)
PF13499
(EF-hand_7) 		4 ILE A 563
VAL A 531
ARG A 612
SER A 566
 None
 1.20A 6f6jA-4il1A:
undetectable		 6f6jA-4il1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k9q BENZOYLFORMATE
DECARBOXYLASE

(Polynucleobacter
necessarius) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		4 ILE A 367
LEU A 512
VAL A 424
SER A 363
 None
 1.29A 6f6jA-4k9qA:
undetectable		 6f6jA-4k9qA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l27 CYSTATHIONINE
BETA-SYNTHASE

(Homo sapiens) 		no annotation 4 ILE B 261
LEU B 287
VAL B 320
ARG B 317
 None
 1.17A 6f6jA-4l27B:
undetectable		 6f6jA-4l27B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lur INTERPHOTORECEPTOR
RETINOID-BINDING
PROTEIN(IRBP)

(Danio rerio) 		PF03572
(Peptidase_S41)
PF11918
(Peptidase_S41_N) 		4 ILE A 204
LEU A 287
VAL A 231
ARG A 146
 None
 1.23A 6f6jA-4lurA:
undetectable		 6f6jA-4lurA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mix PUTATIVE
INSECTICIDAL TOXIN

(Photorhabdus
asymbiotica) 		PF04488
(Gly_transf_sug) 		4 ILE A2294
LEU A2362
VAL A2296
ARG A2413
 None
 1.18A 6f6jA-4mixA:
undetectable		 6f6jA-4mixA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4my0 GCN5-RELATED
N-ACETYLTRANSFERASE

(Kribbella
flavida) 		PF13527
(Acetyltransf_9)
PF13530
(SCP2_2) 		4 ILE A  82
TYR A 131
LEU A 129
VAL A 104
 None
 1.15A 6f6jA-4my0A:
undetectable		 6f6jA-4my0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pb0 AB53 LIGHT CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 ILE L  75
TYR L  86
LEU L  11
VAL L  78
 None
 1.17A 6f6jA-4pb0L:
undetectable		 6f6jA-4pb0L:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r7x ARRESTIN
DOMAIN-CONTAINING
PROTEIN 3

(Homo sapiens) 		PF00339
(Arrestin_N) 		4 ILE A  89
TYR A 112
LEU A  36
VAL A  44
 None
PO4  A 206 (-4.7A)
None
None
 1.26A 6f6jA-4r7xA:
undetectable		 6f6jA-4r7xA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rnz CONSERVED
HYPOTHETICAL
SECRETED PROTEIN

(Helicobacter
pylori) 		PF01551
(Peptidase_M23) 		4 ILE A 295
TYR A 304
VAL A 320
SER A 276
 None
 1.23A 6f6jA-4rnzA:
undetectable		 6f6jA-4rnzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v0j ACYL-[ACYL-CARRIER-P
ROTEIN] DESATURASE,
CHLOROPLASTIC

(Ricinus
communis) 		PF03405
(FA_desaturase_2) 		4 ILE A 190
LEU A 304
VAL A 240
SER A 193
 None
 1.28A 6f6jA-4v0jA:
undetectable		 6f6jA-4v0jA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wp6 MRNA EXPORT PROTEIN

(Chaetomium
thermophilum) 		PF14580
(LRR_9) 		4 ILE A 263
TYR A 208
LEU A 214
ARG A 291
 None
 0.98A 6f6jA-4wp6A:
undetectable		 6f6jA-4wp6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zlv ORNITHINE
AMINOTRANSFERASE,
MITOCHONDRIAL,
PUTATIVE

(Toxoplasma
gondii) 		PF00202
(Aminotran_3) 		4 ILE A 368
TYR A 359
LEU A 358
VAL A 377
 None
 1.21A 6f6jA-4zlvA:
undetectable		 6f6jA-4zlvA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a01 O-GLYCOSYLTRANSFERAS
E

(Drosophila
melanogaster) 		PF13374
(TPR_10)
PF13414
(TPR_11)
PF13844
(Glyco_transf_41) 		4 ILE A 586
TYR A 588
LEU A1036
VAL A 614
 None
 1.22A 6f6jA-5a01A:
undetectable		 6f6jA-5a01A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5btu PYRI4

(Streptomyces
rugosporus) 		no annotation 4 TYR A 156
LEU A 123
VAL A 181
SER A 121
 None
PEG  A 204 ( 4.7A)
None
PEG  A 202 ( 4.8A)
 1.29A 6f6jA-5btuA:
undetectable		 6f6jA-5btuA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dot CARBAMOYL-PHOSPHATE
SYNTHASE [AMMONIA],
MITOCHONDRIAL

(Homo sapiens) 		PF00117
(GATase)
PF00988
(CPSase_sm_chain)
PF02142
(MGS)
PF02786
(CPSase_L_D2)
PF02787
(CPSase_L_D3) 		4 ILE A1357
LEU A1488
ARG A1481
SER A1485
 None
 1.07A 6f6jA-5dotA:
undetectable		 6f6jA-5dotA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e02 FRQ-INTERACTING RNA
HELICASE

(Neurospora
crassa) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF08148
(DSHCT)
PF13234
(rRNA_proc-arch) 		4 LEU A1015
VAL A 920
ARG A 917
SER A 916
 None
 1.29A 6f6jA-5e02A:
undetectable		 6f6jA-5e02A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e6k POLYKETIDE SYNTHASE
PKSL

(Bacillus
subtilis) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		4 ILE A 293
TYR A 288
VAL A 420
SER A 297
 None
 1.25A 6f6jA-5e6kA:
undetectable		 6f6jA-5e6kA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ei0 SERPIN A12

(Homo sapiens) 		PF00079
(Serpin) 		4 ILE A 386
TYR A 390
LEU A 392
VAL A 308
 None
 1.16A 6f6jA-5ei0A:
undetectable		 6f6jA-5ei0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eny POLYKETIDE SYNTHASE
PKSL

(Bacillus
subtilis) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		4 ILE A 293
TYR A 288
VAL A 420
SER A 297
 None
 1.25A 6f6jA-5enyA:
undetectable		 6f6jA-5enyA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gwj DNA TOPOISOMERASE
2-BETA

(Homo sapiens) 		PF00521
(DNA_topoisoIV)
PF01751
(Toprim)
PF16898
(TOPRIM_C) 		4 ILE A 861
LEU A1191
VAL A 889
ARG A 886
 None
 1.17A 6f6jA-5gwjA:
undetectable		 6f6jA-5gwjA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gzh ENDO-BETA-1,2-GLUCAN
ASE

(Chitinophaga
pinensis) 		PF10091
(Glycoamylase) 		4 ILE A 147
LEU A 174
VAL A 178
ARG A 112
 None
 1.13A 6f6jA-5gzhA:
undetectable		 6f6jA-5gzhA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iwl 5F9 DIABODY

(Homo sapiens) 		no annotation 4 ILE B 202
TYR B 213
LEU B 133
VAL B 205
 None
 1.21A 6f6jA-5iwlB:
undetectable		 6f6jA-5iwlB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l37 MSM0273

(Mycolicibacterium
smegmatis) 		PF03319
(EutN_CcmL) 		4 ILE A  73
LEU A  25
VAL A  50
SER A  44
 None
 1.13A 6f6jA-5l37A:
undetectable		 6f6jA-5l37A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ldy IG DOMAIN PROTEIN
GROUP 1 DOMAIN
PROTEIN

(Yersinia
pseudotuberculosis) 		PF09134
(Invasin_D3) 		4 TYR A1703
VAL A1678
ARG A1671
SER A1647
 None
 1.27A 6f6jA-5ldyA:
undetectable		 6f6jA-5ldyA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m6g BETA-GLUCOSIDASE

(Saccharopolyspora
erythraea) 		no annotation 4 ILE A 465
LEU A 557
VAL A 497
SER A 559
 None
 1.27A 6f6jA-5m6gA:
undetectable		 6f6jA-5m6gA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n9j MEDIATOR OF RNA
POLYMERASE II
TRANSCRIPTION
SUBUNIT 20

(Schizosaccharomyces
pombe) 		PF08612
(Med20) 		4 ILE Y  98
LEU Y 181
VAL Y 115
ARG Y 185
 None
 1.16A 6f6jA-5n9jY:
undetectable		 6f6jA-5n9jY:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nek PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE

(Bacillus cereus) 		no annotation 4 ILE A 212
TYR A 200
LEU A 196
SER A 195
 None
 1.24A 6f6jA-5nekA:
undetectable		 6f6jA-5nekA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o3z SORBITOL-6-PHOSPHATE
DEHYDROGENASE

(Erwinia
amylovora) 		no annotation 4 ILE A 136
TYR A 116
LEU A 164
VAL A 179
 None
 1.16A 6f6jA-5o3zA:
undetectable		 6f6jA-5o3zA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5of4 TFIIH BASAL
TRANSCRIPTION FACTOR
COMPLEX HELICASE XPD
SUBUNIT

(Homo sapiens) 		PF06733
(DEAD_2)
PF06777
(HBB)
PF13307
(Helicase_C_2) 		4 ILE B  71
TYR B 207
ARG B 450
SER B 222
 None
 0.87A 6f6jA-5of4B:
undetectable		 6f6jA-5of4B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5udb DNA REPLICATION
LICENSING FACTOR
MCM3

(Saccharomyces
cerevisiae) 		PF00493
(MCM)
PF17207
(MCM_OB) 		4 ILE 3  96
LEU 3  32
VAL 3  42
ARG 3  39
 None
 1.27A 6f6jA-5udb3:
undetectable		 6f6jA-5udb3:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ve9 MICROTUBULE-ACTIN
CROSS-LINKING FACTOR
1, ISOFORMS 1/2/3/5

(Homo sapiens) 		PF13499
(EF-hand_7) 		4 ILE A7070
TYR A7035
ARG A7052
SER A7073
 None
 0.93A 6f6jA-5ve9A:
undetectable		 6f6jA-5ve9A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w5j RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2

(Homo sapiens) 		no annotation 4 ILE A 124
LEU A 106
VAL A 222
ARG A 225
 None
None
None
SO4  A 402 (-3.8A)
 1.15A 6f6jA-5w5jA:
undetectable		 6f6jA-5w5jA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xa2 CYSTEINE SYNTHASE

(Planctopirus
limnophila) 		PF00291
(PALP) 		4 ILE A 182
LEU A 210
VAL A 237
ARG A 234
 None
 0.97A 6f6jA-5xa2A:
undetectable		 6f6jA-5xa2A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xwq FUNGAL CHITINASE
FROM RHIZOMUCOR
MIEHEI (NATIVE
PROTEIN)

(Rhizomucor
miehei) 		no annotation 4 ILE A 320
TYR A 389
VAL A 328
SER A 323
 None
 1.27A 6f6jA-5xwqA:
undetectable		 6f6jA-5xwqA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zal ENDORIBONUCLEASE
DICER

(Homo sapiens) 		no annotation 4 ILE A1673
TYR A1754
LEU A1815
VAL A1833
 None
 0.85A 6f6jA-5zalA:
undetectable		 6f6jA-5zalA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6btm ALTERNATIVE COMPLEX
III SUBUNIT F

(Flavobacterium
johnsoniae) 		no annotation 4 ILE F 149
LEU F 120
VAL F 124
SER F 293
 None
 1.23A 6f6jA-6btmF:
undetectable		 6f6jA-6btmF:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c7y TYROSINE-PROTEIN
KINASE JAK1

(Homo sapiens) 		no annotation 4 LEU A1024
VAL A1037
ARG A1041
SER A1043
 None
PTR  A1035 ( 3.1A)
None
None
 0.82A 6f6jA-6c7yA:
undetectable		 6f6jA-6c7yA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c8z ADP-DEPENDENT
PHOSPHOFRUCTOKINASE

(Methanosarcinales) 		no annotation 4 ILE A 347
TYR A 323
LEU A 321
ARG A 301
 None
 1.14A 6f6jA-6c8zA:
undetectable		 6f6jA-6c8zA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6en4 SPLICING FACTOR 3B
SUBUNIT 1

(Homo sapiens) 		no annotation 4 ILE C 596
LEU C 581
VAL C 553
ARG C 549
 None
 1.16A 6f6jA-6en4C:
undetectable		 6f6jA-6en4C:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f1y CYTOPLASMIC DYNEIN 1
LIGHT INTERMEDIATE
CHAIN 2

(Homo sapiens) 		no annotation 4 ILE j 134
TYR j 284
LEU j 280
VAL j 230
 None
 0.98A 6f6jA-6f1yj:
undetectable		 6f6jA-6f1yj:
undetectable