SIMILAR PATTERNS OF AMINO ACIDS FOR 6F5U_A_CQNA610

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a6d THERMOSOME (ALPHA
SUBUNIT)

(Thermoplasma
acidophilum) 		PF00118
(Cpn60_TCP1) 		5 VAL A 288
ALA A 237
LEU A 302
LEU A 333
LEU A 243
 None
 0.96A 6f5uA-1a6dA:
undetectable
6f5uB-1a6dA:
0.5		 6f5uA-1a6dA:
9.01
6f5uB-1a6dA:
10.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1brt BROMOPEROXIDASE A2

(Kitasatospora
aureofaciens) 		PF00561
(Abhydrolase_1) 		6 VAL A  95
LEU A 122
LEU A 260
LEU A  46
THR A  55
LEU A 271
 None
 1.14A 6f5uA-1brtA:
0.1
6f5uB-1brtA:
undetectable		 6f5uA-1brtA:
15.33
6f5uB-1brtA:
12.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1brw PROTEIN (PYRIMIDINE
NUCLEOSIDE
PHOSPHORYLASE)

(Geobacillus
stearothermophilus) 		PF00591
(Glycos_transf_3)
PF02885
(Glycos_trans_3N)
PF07831
(PYNP_C) 		5 VAL A 253
ALA A 256
LEU A 313
LEU A 326
LEU A 329
 None
 0.97A 6f5uA-1brwA:
0.0
6f5uB-1brwA:
undetectable		 6f5uA-1brwA:
12.25
6f5uB-1brwA:
12.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hkh GAMMA LACTAMASE

(Microbacterium) 		PF00561
(Abhydrolase_1) 		6 VAL A  95
LEU A 122
LEU A 262
LEU A  46
THR A  55
LEU A 273
 None
 1.09A 6f5uA-1hkhA:
0.0
6f5uB-1hkhA:
undetectable		 6f5uA-1hkhA:
15.97
6f5uB-1hkhA:
13.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jl5 OUTER PROTEIN YOPM

(Yersinia pestis) 		PF12468
(TTSSLRR) 		5 VAL A1118
LEU A1123
LEU A1143
LEU A1109
LEU A1106
 None
 0.93A 6f5uA-1jl5A:
0.2
6f5uB-1jl5A:
undetectable		 6f5uA-1jl5A:
10.47
6f5uB-1jl5A:
11.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jl5 OUTER PROTEIN YOPM

(Yersinia pestis) 		PF12468
(TTSSLRR) 		5 VAL A1138
LEU A1143
LEU A1165
LEU A1129
LEU A1126
 None
 0.83A 6f5uA-1jl5A:
0.2
6f5uB-1jl5A:
undetectable		 6f5uA-1jl5A:
10.47
6f5uB-1jl5A:
11.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jl5 OUTER PROTEIN YOPM

(Yersinia pestis) 		PF12468
(TTSSLRR) 		5 VAL A1160
LEU A1165
LEU A1185
LEU A1149
LEU A1146
 None
 0.98A 6f5uA-1jl5A:
0.2
6f5uB-1jl5A:
undetectable		 6f5uA-1jl5A:
10.47
6f5uB-1jl5A:
11.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jl5 OUTER PROTEIN YOPM

(Yersinia pestis) 		PF12468
(TTSSLRR) 		5 VAL A1324
LEU A1329
LEU A1349
LEU A1315
LEU A1312
 None
 0.88A 6f5uA-1jl5A:
0.2
6f5uB-1jl5A:
undetectable		 6f5uA-1jl5A:
10.47
6f5uB-1jl5A:
11.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1odo PUTATIVE CYTOCHROME
P450 154A1

(Streptomyces
coelicolor) 		PF00067
(p450) 		5 VAL A  33
ALA A  40
LEU A  10
LEU A 393
LEU A  24
 None
 0.82A 6f5uA-1odoA:
undetectable
6f5uB-1odoA:
0.0		 6f5uA-1odoA:
10.29
6f5uB-1odoA:
14.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1su7 CARBON MONOXIDE
DEHYDROGENASE 2

(Carboxydothermus
hydrogenoformans) 		PF03063
(Prismane) 		5 ALA A 415
LEU A 428
LEU A 521
MET A 523
LEU A 470
 None
 0.95A 6f5uA-1su7A:
0.2
6f5uB-1su7A:
undetectable		 6f5uA-1su7A:
8.05
6f5uB-1su7A:
8.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ua2 CELL DIVISION
PROTEIN KINASE 7

(Homo sapiens) 		PF00069
(Pkinase) 		5 ALA A 116
LEU A 206
LEU A 145
THR A 302
LEU A  98
 None
 0.89A 6f5uA-1ua2A:
undetectable
6f5uB-1ua2A:
0.0		 6f5uA-1ua2A:
14.02
6f5uB-1ua2A:
14.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vhk HYPOTHETICAL PROTEIN
YQEU

(Bacillus
subtilis) 		PF04452
(Methyltrans_RNA) 		5 VAL A 202
ALA A  84
LEU A 217
LEU A 161
LEU A 209
 None
 0.96A 6f5uA-1vhkA:
undetectable
6f5uB-1vhkA:
undetectable		 6f5uA-1vhkA:
18.75
6f5uB-1vhkA:
17.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wdw TRYPTOPHAN SYNTHASE
BETA CHAIN 1

(Pyrococcus
furiosus) 		PF00291
(PALP) 		5 VAL B 350
ALA B 353
LEU B 370
LEU B  59
LEU B 334
 None
 0.93A 6f5uA-1wdwB:
undetectable
6f5uB-1wdwB:
undetectable		 6f5uA-1wdwB:
12.61
6f5uB-1wdwB:
13.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2brt LEUCOANTHOCYANIDIN
DIOXYGENASE

(Arabidopsis
thaliana) 		PF03171
(2OG-FeII_Oxy)
PF14226
(DIOX_N) 		6 VAL A 183
ALA A 180
LEU A 187
LEU A 275
LEU A  82
LEU A  70
 None
 1.36A 6f5uA-2brtA:
undetectable
6f5uB-2brtA:
0.0		 6f5uA-2brtA:
14.81
6f5uB-2brtA:
13.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ef0 ORNITHINE
CARBAMOYLTRANSFERASE

(Thermus
thermophilus) 		PF00185
(OTCace)
PF02729
(OTCace_N) 		5 VAL A 157
ALA A 216
LEU A 179
LEU A 152
LEU A 170
 None
 0.89A 6f5uA-2ef0A:
undetectable
6f5uB-2ef0A:
undetectable		 6f5uA-2ef0A:
15.33
6f5uB-2ef0A:
14.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fr1 ERYTHROMYCIN
SYNTHASE, ERYAI

(Saccharopolyspora
erythraea) 		PF08659
(KR) 		5 VAL A1796
ALA A1794
LEU A1685
THR A1793
LEU A1873
 None
 0.91A 6f5uA-2fr1A:
undetectable
6f5uB-2fr1A:
undetectable		 6f5uA-2fr1A:
10.50
6f5uB-2fr1A:
10.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2peb PUTATIVE DIOXYGENASE

(Nostoc
punctiforme) 		PF08883
(DOPA_dioxygen) 		5 ARG A  29
VAL A  28
ALA A  25
LEU A  32
LEU A  72
 None
 0.88A 6f5uA-2pebA:
undetectable
6f5uB-2pebA:
0.0		 6f5uA-2pebA:
24.17
6f5uB-2pebA:
26.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pma UNCHARACTERIZED
PROTEIN

(Legionella
pneumophila) 		PF05618
(Zn_protease) 		5 VAL A  75
ALA A  57
LEU A  35
LEU A 118
LEU A  42
 None
 0.98A 6f5uA-2pmaA:
undetectable
6f5uB-2pmaA:
undetectable		 6f5uA-2pmaA:
21.97
6f5uB-2pmaA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qqk NEUROPILIN-2

(Homo sapiens) 		PF00431
(CUB)
PF00754
(F5_F8_type_C) 		5 VAL A 407
LEU A 339
LEU A 398
LEU A 422
LEU A 424
 None
 0.82A 6f5uA-2qqkA:
undetectable
6f5uB-2qqkA:
undetectable		 6f5uA-2qqkA:
10.04
6f5uB-2qqkA:
11.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qqo NEUROPILIN-2

(Homo sapiens) 		PF00431
(CUB)
PF00754
(F5_F8_type_C) 		5 VAL A 407
LEU A 339
LEU A 398
LEU A 422
LEU A 424
 None
 0.83A 6f5uA-2qqoA:
undetectable
6f5uB-2qqoA:
undetectable		 6f5uA-2qqoA:
12.17
6f5uB-2qqoA:
10.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qy6 UPF0209 PROTEIN YFCK

(Escherichia
coli) 		PF05430
(Methyltransf_30) 		6 VAL A  82
ALA A 194
LEU A 115
LEU A  63
THR A 226
LEU A  96
 None
 1.39A 6f5uA-2qy6A:
undetectable
6f5uB-2qy6A:
undetectable		 6f5uA-2qy6A:
15.96
6f5uB-2qy6A:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uzh 2C-METHYL-D-ERYTHRIT
OL
2,4-CYCLODIPHOSPHATE
SYNTHASE

(Mycolicibacterium
smegmatis) 		PF02542
(YgbB) 		5 VAL A 127
ALA A 125
LEU A 119
LEU A  51
LEU A  47
 None
 1.00A 6f5uA-2uzhA:
undetectable
6f5uB-2uzhA:
undetectable		 6f5uA-2uzhA:
22.52
6f5uB-2uzhA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vk4 PYRUVATE
DECARBOXYLASE

(Kluyveromyces
lactis) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		5 VAL A  98
LEU A  33
LEU A  34
LEU A  14
LEU A  10
 None
 0.93A 6f5uA-2vk4A:
undetectable
6f5uB-2vk4A:
undetectable		 6f5uA-2vk4A:
9.98
6f5uB-2vk4A:
9.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2we5 CARBAMATE KINASE 1

(Enterococcus
faecalis) 		PF00696
(AA_kinase) 		5 VAL A  47
LEU A   9
LEU A  94
THR A 109
LEU A  35
 None
 0.79A 6f5uA-2we5A:
undetectable
6f5uB-2we5A:
undetectable		 6f5uA-2we5A:
15.25
6f5uB-2we5A:
14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xly CLOQ

(Streptomyces
roseochromogenus) 		PF11468
(PTase_Orf2) 		5 VAL A 173
ALA A 162
LEU A 220
LEU A 222
LEU A 135
 None
 0.95A 6f5uA-2xlyA:
undetectable
6f5uB-2xlyA:
undetectable		 6f5uA-2xlyA:
15.14
6f5uB-2xlyA:
13.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xy9 ANGIOTENSIN-CONVERTI
NG ENZYME

(Homo sapiens) 		PF01401
(Peptidase_M2) 		5 VAL A 251
ALA A 254
LEU A 247
LEU A 603
LEU A 452
 None
 0.95A 6f5uA-2xy9A:
undetectable
6f5uB-2xy9A:
undetectable		 6f5uA-2xy9A:
9.21
6f5uB-2xy9A:
9.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3csy ENVELOPE
GLYCOPROTEIN GP2

(Zaire
ebolavirus) 		no annotation 5 LEU J 515
TYR J 517
THR J 519
MET J 548
LEU J 558
 None
 0.66A 6f5uA-3csyJ:
undetectable
6f5uB-3csyJ:
9.6		 6f5uA-3csyJ:
21.01
6f5uB-3csyJ:
98.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cvr INVASION PLASMID
ANTIGEN

(Shigella
flexneri) 		PF12468
(TTSSLRR)
PF14496
(NEL) 		5 VAL A 127
LEU A 132
LEU A 152
LEU A 118
LEU A 115
 None
 0.82A 6f5uA-3cvrA:
undetectable
6f5uB-3cvrA:
undetectable		 6f5uA-3cvrA:
8.95
6f5uB-3cvrA:
8.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cvr INVASION PLASMID
ANTIGEN

(Shigella
flexneri) 		PF12468
(TTSSLRR)
PF14496
(NEL) 		5 VAL A 167
LEU A 172
LEU A 192
LEU A 158
LEU A 155
 None
 0.94A 6f5uA-3cvrA:
undetectable
6f5uB-3cvrA:
undetectable		 6f5uA-3cvrA:
8.95
6f5uB-3cvrA:
8.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dtt NADP OXIDOREDUCTASE

(Arthrobacter
sp. FB24) 		PF03807
(F420_oxidored) 		5 VAL A  75
ALA A   4
LEU A  96
THR A  27
LEU A  88
 None
 0.91A 6f5uA-3dttA:
undetectable
6f5uB-3dttA:
undetectable		 6f5uA-3dttA:
15.49
6f5uB-3dttA:
13.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g06 SSPH2 (LEUCINE-RICH
REPEAT PROTEIN)

(Salmonella
enterica) 		PF14496
(NEL) 		5 VAL A 309
LEU A 314
LEU A 334
LEU A 300
LEU A 297
 None
 0.92A 6f5uA-3g06A:
undetectable
6f5uB-3g06A:
undetectable		 6f5uA-3g06A:
9.43
6f5uB-3g06A:
8.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g06 SSPH2 (LEUCINE-RICH
REPEAT PROTEIN)

(Salmonella
enterica) 		PF14496
(NEL) 		5 VAL A 349
LEU A 354
LEU A 374
LEU A 340
LEU A 337
 None
 0.91A 6f5uA-3g06A:
undetectable
6f5uB-3g06A:
undetectable		 6f5uA-3g06A:
9.43
6f5uB-3g06A:
8.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g06 SSPH2 (LEUCINE-RICH
REPEAT PROTEIN)

(Salmonella
enterica) 		PF14496
(NEL) 		5 VAL A 389
LEU A 394
LEU A 414
LEU A 380
LEU A 377
 None
 0.89A 6f5uA-3g06A:
undetectable
6f5uB-3g06A:
undetectable		 6f5uA-3g06A:
9.43
6f5uB-3g06A:
8.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g06 SSPH2 (LEUCINE-RICH
REPEAT PROTEIN)

(Salmonella
enterica) 		PF14496
(NEL) 		5 VAL A 409
LEU A 414
LEU A 434
LEU A 400
LEU A 397
 None
 0.87A 6f5uA-3g06A:
undetectable
6f5uB-3g06A:
undetectable		 6f5uA-3g06A:
9.43
6f5uB-3g06A:
8.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g06 SSPH2 (LEUCINE-RICH
REPEAT PROTEIN)

(Salmonella
enterica) 		PF14496
(NEL) 		5 VAL A 429
LEU A 434
LEU A 457
LEU A 420
LEU A 417
 None
 0.95A 6f5uA-3g06A:
undetectable
6f5uB-3g06A:
undetectable		 6f5uA-3g06A:
9.43
6f5uB-3g06A:
8.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g8a RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G

(Thermus
thermophilus) 		PF02527
(GidB) 		5 VAL A 224
ALA A 182
LEU A 206
LEU A 199
LEU A 192
 None
 0.69A 6f5uA-3g8aA:
undetectable
6f5uB-3g8aA:
undetectable		 6f5uA-3g8aA:
15.61
6f5uB-3g8aA:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j7a 40S RIBOSOMAL
PROTEIN ES10

(Plasmodium
falciparum) 		PF03501
(S10_plectin) 		5 VAL O  66
LEU O  57
LEU O  87
TYR O  86
LEU O  26
 None
 0.93A 6f5uA-3j7aO:
undetectable
6f5uB-3j7aO:
undetectable		 6f5uA-3j7aO:
19.12
6f5uB-3j7aO:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m70 TELLURITE RESISTANCE
PROTEIN TEHB HOMOLOG

(Haemophilus
influenzae) 		PF03848
(TehB)
PF09313
(DUF1971) 		5 VAL A  78
LEU A  44
LEU A  85
LEU A  89
LEU A  37
 None
 0.99A 6f5uA-3m70A:
undetectable
6f5uB-3m70A:
undetectable		 6f5uA-3m70A:
14.89
6f5uB-3m70A:
15.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mpl VIRULENCE SENSOR
PROTEIN BVGS

(Bordetella
pertussis) 		PF00497
(SBP_bac_3) 		6 ARG A 415
VAL A 417
ALA A 458
LEU A 484
THR A 399
LEU A 429
 None
 1.06A 6f5uA-3mplA:
0.1
6f5uB-3mplA:
undetectable		 6f5uA-3mplA:
14.44
6f5uB-3mplA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mwt NUCLEOPROTEIN

(Lassa
mammarenavirus) 		PF00843
(Arena_nucleocap)
PF17290
(Arena_ncap_C) 		5 VAL A 449
ALA A 452
LEU A 445
LEU A 365
LEU A 554
 None
 0.96A 6f5uA-3mwtA:
undetectable
6f5uB-3mwtA:
undetectable		 6f5uA-3mwtA:
9.84
6f5uB-3mwtA:
8.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ps9 TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC

(Escherichia
coli) 		PF01266
(DAO)
PF05430
(Methyltransf_30) 		6 VAL A  62
ALA A 174
LEU A  95
LEU A  43
THR A 206
LEU A  76
 None
 1.33A 6f5uA-3ps9A:
0.6
6f5uB-3ps9A:
undetectable		 6f5uA-3ps9A:
8.96
6f5uB-3ps9A:
9.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pvc TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC

(Yersinia pestis) 		PF01266
(DAO)
PF05430
(Methyltransf_30) 		5 VAL A 461
ALA A 268
LEU A 435
THR A 291
LEU A 438
 None
None
FAD  A 690 (-4.6A)
None
None
 0.97A 6f5uA-3pvcA:
undetectable
6f5uB-3pvcA:
undetectable		 6f5uA-3pvcA:
8.18
6f5uB-3pvcA:
9.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q71 POLY [ADP-RIBOSE]
POLYMERASE 14

(Homo sapiens) 		PF01661
(Macro) 		5 VAL A1031
ALA A1128
LEU A1084
LEU A1046
LEU A1050
 None
None
None
AR6  A 800 (-3.6A)
None
 0.99A 6f5uA-3q71A:
undetectable
6f5uB-3q71A:
undetectable		 6f5uA-3q71A:
19.15
6f5uB-3q71A:
15.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q7b NUCLEOPROTEIN

(Lassa
mammarenavirus) 		PF17290
(Arena_ncap_C) 		5 VAL A 449
ALA A 452
LEU A 445
LEU A 365
LEU A 554
 None
 0.99A 6f5uA-3q7bA:
undetectable
6f5uB-3q7bA:
undetectable		 6f5uA-3q7bA:
12.20
6f5uB-3q7bA:
14.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3s88 ENVELOPE
GLYCOPROTEIN

(Sudan
ebolavirus) 		PF01611
(Filo_glycop)
no annotation 		8 VAL I  66
ALA I 101
LEU I 184
LEU I 186
LEU J 515
TYR J 517
THR J 519
LEU J 558
 None
 0.71A 6f5uA-3s88I:
28.2
6f5uB-3s88I:
undetectable		 6f5uA-3s88I:
74.39
6f5uB-3s88I:
14.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wgc L-ALLO-THREONINE
ALDOLASE

(Aeromonas
jandaei) 		PF01212
(Beta_elim_lyase) 		5 VAL A 328
ALA A 331
LEU A   6
LEU A 265
LEU A 261
 None
 0.99A 6f5uA-3wgcA:
undetectable
6f5uB-3wgcA:
undetectable		 6f5uA-3wgcA:
11.82
6f5uB-3wgcA:
13.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wnp CYCLOISOMALTOOLIGOSA
CCHARIDE
GLUCANOTRANSFERASE

(Bacillus
circulans) 		PF13199
(Glyco_hydro_66)
PF16990
(CBM_35) 		5 VAL A 307
ALA A 234
LEU A 351
LEU A 341
LEU A 334
 None
 0.92A 6f5uA-3wnpA:
0.8
6f5uB-3wnpA:
undetectable		 6f5uA-3wnpA:
8.26
6f5uB-3wnpA:
8.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b3g DNA-BINDING PROTEIN
SMUBP-2

(Homo sapiens) 		PF13086
(AAA_11)
PF13087
(AAA_12) 		5 ALA A 350
LEU A 280
LEU A 361
THR A 351
LEU A 342
 None
None
None
A  G   8 ( 2.6A)
None
 0.97A 6f5uA-4b3gA:
undetectable
6f5uB-4b3gA:
undetectable		 6f5uA-4b3gA:
9.60
6f5uB-4b3gA:
8.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4brj DESULFOFERRODOXIN,
FERROUS IRON-BINDING
REGION

(Ignicoccus
hospitalis) 		PF01880
(Desulfoferrodox) 		5 VAL A  43
ALA A  31
LEU A  95
LEU A  97
LEU A  63
 None
 0.80A 6f5uA-4brjA:
undetectable
6f5uB-4brjA:
undetectable		 6f5uA-4brjA:
22.58
6f5uB-4brjA:
24.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cnm TROPHOBLAST
GLYCOPROTEIN

(Homo sapiens) 		PF01462
(LRRNT)
PF01463
(LRRCT)
PF13855
(LRR_8) 		5 ALA A 137
LEU A 144
LEU A 175
LEU A 125
LEU A 123
 None
 0.92A 6f5uA-4cnmA:
undetectable
6f5uB-4cnmA:
undetectable		 6f5uA-4cnmA:
13.71
6f5uB-4cnmA:
15.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4df9 PUTATIVE PEPTIDASE

(Bacteroides
fragilis) 		PF09471
(Peptidase_M64)
PF16217
(M64_N) 		5 VAL A 145
LEU A  31
LEU A 117
LEU A  48
LEU A  51
 None
 0.98A 6f5uA-4df9A:
1.8
6f5uB-4df9A:
undetectable		 6f5uA-4df9A:
11.40
6f5uB-4df9A:
11.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ef1 PHEROMONE
COB1/LIPOPROTEIN,
YAEC FAMILY

(Enterococcus
faecalis) 		PF03180
(Lipoprotein_9) 		5 VAL A  34
ALA A  36
LEU A 246
LEU A 250
LEU A  59
 None
 0.97A 6f5uA-4ef1A:
undetectable
6f5uB-4ef1A:
undetectable		 6f5uA-4ef1A:
18.52
6f5uB-4ef1A:
14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4es6 UROPORPHYRINOGEN-III
SYNTHASE

(Pseudomonas
aeruginosa) 		PF02602
(HEM4) 		5 VAL A  27
LEU A   6
LEU A   8
LEU A 244
LEU A 247
 None
None
CL  A 301 ( 4.6A)
None
None
 0.91A 6f5uA-4es6A:
undetectable
6f5uB-4es6A:
undetectable		 6f5uA-4es6A:
15.51
6f5uB-4es6A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fbh PROTEIN SYNTHESIS
INHIBITOR I

(Hordeum vulgare) 		PF00161
(RIP) 		5 ALA A 165
LEU A  88
LEU A 101
LEU A  77
LEU A  79
 None
 0.92A 6f5uA-4fbhA:
undetectable
6f5uB-4fbhA:
undetectable		 6f5uA-4fbhA:
16.00
6f5uB-4fbhA:
13.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fp9 MTERF
DOMAIN-CONTAINING
PROTEIN 2

(Homo sapiens) 		PF02536
(mTERF) 		5 LEU B 180
LEU B 176
LEU B 154
MET B 159
LEU B 151
 None
 0.99A 6f5uA-4fp9B:
undetectable
6f5uB-4fp9B:
undetectable		 6f5uA-4fp9B:
11.52
6f5uB-4fp9B:
15.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g1g MATRIX PROTEIN

(Avian
avulavirus 1) 		PF00661
(Matrix) 		5 VAL A 280
ALA A 300
LEU A 266
LEU A 264
LEU A 206
 None
 0.84A 6f5uA-4g1gA:
undetectable
6f5uB-4g1gA:
undetectable		 6f5uA-4g1gA:
12.15
6f5uB-4g1gA:
12.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iq4 NON-HAEM
BROMOPEROXIDASE
BPO-A2, MATRIX
PROTEIN 1

(Influenza A
virus;
Kitasatospora
aureofaciens) 		PF00561
(Abhydrolase_1)
PF00598
(Flu_M1) 		6 VAL A  95
LEU A 122
LEU A 260
LEU A  46
THR A  55
LEU A 271
 None
 1.08A 6f5uA-4iq4A:
undetectable
6f5uB-4iq4A:
undetectable		 6f5uA-4iq4A:
11.06
6f5uB-4iq4A:
14.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iqh DYSFERLIN

(Homo sapiens) 		PF00168
(C2) 		5 VAL A 123
ALA A 101
LEU A   3
LEU A  61
LEU A  67
 None
 1.00A 6f5uA-4iqhA:
undetectable
6f5uB-4iqhA:
undetectable		 6f5uA-4iqhA:
22.96
6f5uB-4iqhA:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k3f PROBABLE
TONB-DEPENDENT
RECEPTOR

(Pseudomonas
aeruginosa) 		PF03180
(Lipoprotein_9) 		5 VAL A  27
ALA A  29
LEU A 235
LEU A 239
LEU A  52
 None
 0.98A 6f5uA-4k3fA:
undetectable
6f5uB-4k3fA:
undetectable		 6f5uA-4k3fA:
15.18
6f5uB-4k3fA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nkh E3 UBIQUITIN-PROTEIN
LIGASE SSPH1

(Salmonella
enterica) 		no annotation 6 VAL A 284
LEU A 289
LEU A 309
LEU A 275
MET A 295
LEU A 272
 None
 1.24A 6f5uA-4nkhA:
undetectable
6f5uB-4nkhA:
undetectable		 6f5uA-4nkhA:
15.19
6f5uB-4nkhA:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o8s PUTATIVE

(Helicobacter
pylori) 		PF08843
(AbiEii) 		5 ARG A  69
VAL A  70
ALA A  73
LEU A  66
LEU A 112
 None
 0.89A 6f5uA-4o8sA:
undetectable
6f5uB-4o8sA:
undetectable		 6f5uA-4o8sA:
20.00
6f5uB-4o8sA:
13.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ok0 PUTATIVE

(Helicobacter
pylori) 		PF08843
(AbiEii) 		5 ARG A  69
VAL A  70
ALA A  73
LEU A  66
LEU A 112
 None
 0.83A 6f5uA-4ok0A:
undetectable
6f5uB-4ok0A:
undetectable		 6f5uA-4ok0A:
14.57
6f5uB-4ok0A:
13.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ote LIPOPROTEIN

(Clostridioides
difficile) 		PF03180
(Lipoprotein_9) 		5 VAL A  33
ALA A  35
LEU A 240
LEU A 244
LEU A  58
 None
 0.92A 6f5uA-4oteA:
undetectable
6f5uB-4oteA:
undetectable		 6f5uA-4oteA:
17.14
6f5uB-4oteA:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ow2 YOP EFFECTOR YOPM

(Yersinia
enterocolitica) 		PF12468
(TTSSLRR) 		5 VAL A 118
LEU A 123
LEU A 143
LEU A 109
LEU A 106
 None
 0.82A 6f5uA-4ow2A:
undetectable
6f5uB-4ow2A:
undetectable		 6f5uA-4ow2A:
10.24
6f5uB-4ow2A:
10.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ow2 YOP EFFECTOR YOPM

(Yersinia
enterocolitica) 		PF12468
(TTSSLRR) 		5 VAL A 138
LEU A 143
LEU A 165
LEU A 129
LEU A 126
 None
 0.91A 6f5uA-4ow2A:
undetectable
6f5uB-4ow2A:
undetectable		 6f5uA-4ow2A:
10.24
6f5uB-4ow2A:
10.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ow2 YOP EFFECTOR YOPM

(Yersinia
enterocolitica) 		PF12468
(TTSSLRR) 		5 VAL A 180
LEU A 185
LEU A 205
LEU A 171
LEU A 168
 None
 0.97A 6f5uA-4ow2A:
undetectable
6f5uB-4ow2A:
undetectable		 6f5uA-4ow2A:
10.24
6f5uB-4ow2A:
10.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ow2 YOP EFFECTOR YOPM

(Yersinia
enterocolitica) 		PF12468
(TTSSLRR) 		5 VAL A 240
LEU A 245
LEU A 265
LEU A 231
LEU A 228
 None
 0.93A 6f5uA-4ow2A:
undetectable
6f5uB-4ow2A:
undetectable		 6f5uA-4ow2A:
10.24
6f5uB-4ow2A:
10.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ow2 YOP EFFECTOR YOPM

(Yersinia
enterocolitica) 		PF12468
(TTSSLRR) 		5 VAL A 300
LEU A 305
LEU A 325
LEU A 291
LEU A 288
 None
 0.98A 6f5uA-4ow2A:
undetectable
6f5uB-4ow2A:
undetectable		 6f5uA-4ow2A:
10.24
6f5uB-4ow2A:
10.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ow2 YOP EFFECTOR YOPM

(Yersinia
enterocolitica) 		PF12468
(TTSSLRR) 		5 VAL A 420
LEU A 425
LEU A 445
LEU A 411
LEU A 408
 None
 0.94A 6f5uA-4ow2A:
undetectable
6f5uB-4ow2A:
undetectable		 6f5uA-4ow2A:
10.24
6f5uB-4ow2A:
10.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qdr NEUROPILIN-2

(Homo sapiens) 		PF00754
(F5_F8_type_C) 		5 VAL A 407
LEU A 339
LEU A 398
LEU A 422
LEU A 424
 None
 0.89A 6f5uA-4qdrA:
undetectable
6f5uB-4qdrA:
undetectable		 6f5uA-4qdrA:
15.60
6f5uB-4qdrA:
13.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qds NEUROPILIN-2

(Homo sapiens) 		PF00754
(F5_F8_type_C) 		5 VAL A 407
LEU A 339
LEU A 398
LEU A 422
LEU A 424
 None
 0.89A 6f5uA-4qdsA:
undetectable
6f5uB-4qdsA:
undetectable		 6f5uA-4qdsA:
18.42
6f5uB-4qdsA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r5d LEUCINE RICH REPEAT
PROTEIN

(synthetic
construct) 		PF12354
(Internalin_N)
PF12799
(LRR_4)
PF13516
(LRR_6)
PF13855
(LRR_8) 		5 VAL A 248
ALA A 247
LEU A 276
LEU A 240
LEU A 263
 None
 0.97A 6f5uA-4r5dA:
undetectable
6f5uB-4r5dA:
undetectable		 6f5uA-4r5dA:
11.98
6f5uB-4r5dA:
9.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rhy HYPOXANTHINE-GUANINE
PHOSPHORIBOSYLTRANSF
ERASE

(Mycobacterium
tuberculosis) 		PF00156
(Pribosyltran) 		6 VAL A 121
LEU A  61
LEU A  59
LEU A  40
TYR A 166
LEU A  75
 VAL  A 121 ( 0.6A)
LEU  A  61 ( 0.6A)
LEU  A  59 ( 0.5A)
LEU  A  40 ( 0.6A)
TYR  A 166 ( 1.3A)
LEU  A  75 ( 0.6A)
 1.13A 6f5uA-4rhyA:
undetectable
6f5uB-4rhyA:
undetectable		 6f5uA-4rhyA:
20.93
6f5uB-4rhyA:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rnz CONSERVED
HYPOTHETICAL
SECRETED PROTEIN

(Helicobacter
pylori) 		PF01551
(Peptidase_M23) 		5 ALA A  98
LEU A  55
TYR A  85
THR A  87
LEU A  51
 None
 0.92A 6f5uA-4rnzA:
undetectable
6f5uB-4rnzA:
undetectable		 6f5uA-4rnzA:
13.24
6f5uB-4rnzA:
12.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tkt AT-LESS POLYKETIDE
SYNTHASE

(Streptomyces
platensis) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		6 VAL A3596
ALA A3631
LEU A3655
LEU A3652
LEU A3736
LEU A3613
 None
None
None
SO4  A4003 ( 4.8A)
None
None
 1.25A 6f5uA-4tktA:
undetectable
6f5uB-4tktA:
undetectable		 6f5uA-4tktA:
9.18
6f5uB-4tktA:
9.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u06 LIC10831

(Leptospira
interrogans) 		PF12799
(LRR_4)
PF13855
(LRR_8) 		5 ALA A 227
LEU A 255
LEU A 275
LEU A 222
LEU A 235
 None
 0.94A 6f5uA-4u06A:
undetectable
6f5uB-4u06A:
undetectable		 6f5uA-4u06A:
12.37
6f5uB-4u06A:
14.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4utg SUGAR KINASE

(Burkholderia
pseudomallei) 		PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C) 		6 ALA A  37
LEU A 202
LEU A 307
LEU A 249
MET A 245
LEU A 198
 None
 1.30A 6f5uA-4utgA:
undetectable
6f5uB-4utgA:
undetectable		 6f5uA-4utgA:
14.16
6f5uB-4utgA:
13.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x82 ZINC TRANSPORTER
ZIP4

(Pteropus alecto) 		no annotation 5 ALA B  92
LEU B 118
LEU B 119
LEU B 179
LEU B 135
 None
 0.83A 6f5uA-4x82B:
undetectable
6f5uB-4x82B:
undetectable		 6f5uA-4x82B:
14.63
6f5uB-4x82B:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z61 PHYTOSULFOKINE
RECEPTOR 1

(Daucus carota) 		PF00560
(LRR_1)
PF13855
(LRR_8) 		5 VAL A 106
LEU A 112
LEU A 136
LEU A 117
LEU A  91
 None
 0.91A 6f5uA-4z61A:
undetectable
6f5uB-4z61A:
undetectable		 6f5uA-4z61A:
8.76
6f5uB-4z61A:
8.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b0n E3 UBIQUITIN-PROTEIN
LIGASE IPAH9.8

(Shigella
flexneri) 		PF12468
(TTSSLRR) 		5 VAL A  84
LEU A  89
LEU A 109
LEU A  75
LEU A  71
 None
 1.00A 6f5uA-5b0nA:
undetectable
6f5uB-5b0nA:
undetectable		 6f5uA-5b0nA:
19.78
6f5uB-5b0nA:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dn2 NEUROPILIN-2

(Homo sapiens) 		PF00754
(F5_F8_type_C) 		5 VAL A 407
LEU A 339
LEU A 398
LEU A 422
LEU A 424
 None
 0.84A 6f5uA-5dn2A:
undetectable
6f5uB-5dn2A:
undetectable		 6f5uA-5dn2A:
22.76
6f5uB-5dn2A:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ep0 PUTATIVE REPRESSOR
PROTEIN LUXO

(Photobacterium
angustum) 		PF00072
(Response_reg)
PF00158
(Sigma54_activat) 		5 ARG A 112
VAL A 115
LEU A  23
LEU A 102
LEU A  52
 None
 0.94A 6f5uA-5ep0A:
undetectable
6f5uB-5ep0A:
undetectable		 6f5uA-5ep0A:
12.89
6f5uB-5ep0A:
12.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fhc ENVELOPE
GLYCOPROTEIN

(Zaire
ebolavirus) 		no annotation 5 LEU J 515
TYR J 517
THR J 519
MET J 548
LEU J 558
 None
 0.70A 6f5uA-5fhcJ:
undetectable
6f5uB-5fhcJ:
9.5		 6f5uA-5fhcJ:
18.63
6f5uB-5fhcJ:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fhx ANTIBODY FRAGMENT
HEAVY-CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		5 ALA H 215
LEU H 142
LEU H 209
LEU H 172
LEU H 204
 None
 0.91A 6f5uA-5fhxH:
undetectable
6f5uB-5fhxH:
undetectable		 6f5uA-5fhxH:
11.92
6f5uB-5fhxH:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jju UNCHARACTERIZED
PROTEIN RV2837C

(Mycobacterium
tuberculosis) 		PF01368
(DHH)
PF02272
(DHHA1) 		6 ARG A 294
VAL A 277
ALA A 278
LEU A 300
LEU A 331
LEU A 335
 A  C1003 ( 3.0A)
None
None
None
None
None
 1.44A 6f5uA-5jjuA:
undetectable
6f5uB-5jjuA:
undetectable		 6f5uA-5jjuA:
14.19
6f5uB-5jjuA:
12.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jxm PRIB

(Streptomyces
sp. RM-5-8) 		PF11991
(Trp_DMAT) 		5 ARG A 197
VAL A 196
ALA A 193
LEU A 200
LEU A 237
 None
 0.99A 6f5uA-5jxmA:
undetectable
6f5uB-5jxmA:
undetectable		 6f5uA-5jxmA:
12.03
6f5uB-5jxmA:
12.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kdx METALLOPEPTIDASE

(Pseudomonas
aeruginosa) 		PF13402
(Peptidase_M60) 		5 VAL A 162
ALA A 161
LEU A 194
LEU A 144
LEU A 220
 None
 0.95A 6f5uA-5kdxA:
undetectable
6f5uB-5kdxA:
undetectable		 6f5uA-5kdxA:
6.87
6f5uB-5kdxA:
6.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ken EBOLA SURFACE
GLYCOPROTEIN, GP1
EBOLA SURFACE
GLYCOPROTEIN, GP2

(Zaire
ebolavirus) 		PF01611
(Filo_glycop)
no annotation 		7 ARG A  64
VAL A  66
LEU A 184
LEU A 186
THR B 519
MET B 548
LEU B 558
 None
 1.24A 6f5uA-5kenA:
23.7
6f5uB-5kenA:
undetectable		 6f5uA-5kenA:
98.67
6f5uB-5kenA:
15.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ken EBOLA SURFACE
GLYCOPROTEIN, GP1
EBOLA SURFACE
GLYCOPROTEIN, GP2

(Zaire
ebolavirus) 		PF01611
(Filo_glycop)
no annotation 		7 ARG A  64
VAL A  66
LEU A 184
LEU A 186
TYR B 517
THR B 519
LEU B 558
 None
 1.01A 6f5uA-5kenA:
23.7
6f5uB-5kenA:
undetectable		 6f5uA-5kenA:
98.67
6f5uB-5kenA:
15.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ken EBOLA SURFACE
GLYCOPROTEIN, GP1
EBOLA SURFACE
GLYCOPROTEIN, GP2

(Zaire
ebolavirus) 		PF01611
(Filo_glycop)
no annotation 		6 VAL A  66
LEU A 184
LEU A 186
LEU B 515
MET B 548
LEU B 558
 None
 1.15A 6f5uA-5kenA:
23.7
6f5uB-5kenA:
undetectable		 6f5uA-5kenA:
98.67
6f5uB-5kenA:
15.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ken EBOLA SURFACE
GLYCOPROTEIN, GP1
EBOLA SURFACE
GLYCOPROTEIN, GP2

(Zaire
ebolavirus) 		PF01611
(Filo_glycop)
no annotation 		6 VAL A  66
LEU A 184
LEU A 186
LEU B 515
TYR B 517
LEU B 558
 None
 0.96A 6f5uA-5kenA:
23.7
6f5uB-5kenA:
undetectable		 6f5uA-5kenA:
98.67
6f5uB-5kenA:
15.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lhk LEUCINE
AMINOPEPTIDASE 2,
CHLOROPLASTIC

(Streptomyces
sp. BC16019) 		PF00883
(Peptidase_M17)
PF02789
(Peptidase_M17_N) 		5 VAL A 369
ALA A 459
LEU A 496
THR A 391
LEU A 489
 None
 0.77A 6f5uA-5lhkA:
undetectable
6f5uB-5lhkA:
undetectable		 6f5uA-5lhkA:
10.06
6f5uB-5lhkA:
8.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nfi MINOR FIMBRIUM
ANCHORING SUBUNIT
MFA2

(Porphyromonas
gingivalis) 		no annotation 5 VAL B 187
ALA B 237
LEU B 293
THR B 227
LEU B 252
 None
 0.68A 6f5uA-5nfiB:
undetectable
6f5uB-5nfiB:
undetectable		 6f5uA-5nfiB:
27.84
6f5uB-5nfiB:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nmi CYTOCHROME B-C1
COMPLEX SUBUNIT 1,
MITOCHONDRIAL

(Bos taurus) 		PF00675
(Peptidase_M16)
PF05193
(Peptidase_M16_C) 		5 VAL A 110
ALA A 109
LEU A 208
LEU A 203
LEU A 197
 None
 0.91A 6f5uA-5nmiA:
undetectable
6f5uB-5nmiA:
undetectable		 6f5uA-5nmiA:
11.76
6f5uB-5nmiA:
13.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uqd DUMPY: SHORTER THAN
WILD-TYPE

(Caenorhabditis
elegans) 		no annotation 5 VAL A1528
LEU A1579
LEU A1503
LEU A1587
THR A1449
 None
None
None
None
AKG  A1701 (-3.6A)
 0.87A 6f5uA-5uqdA:
undetectable
6f5uB-5uqdA:
undetectable		 6f5uA-5uqdA:
11.84
6f5uB-5uqdA:
12.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vhf 26S PROTEASOME
NON-ATPASE
REGULATORY SUBUNIT 3

(Homo sapiens) 		PF01399
(PCI)
PF08375
(Rpn3_C) 		5 VAL V 367
ALA V 366
LEU V 337
LEU V 379
LEU V 398
 None
 0.87A 6f5uA-5vhfV:
undetectable
6f5uB-5vhfV:
undetectable		 6f5uA-5vhfV:
17.78
6f5uB-5vhfV:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vhs 26S PROTEASOME
NON-ATPASE
REGULATORY SUBUNIT 3

(Homo sapiens) 		PF01399
(PCI)
PF08375
(Rpn3_C) 		5 VAL V 367
ALA V 366
LEU V 337
LEU V 379
LEU V 398
 None
 0.88A 6f5uA-5vhsV:
undetectable
6f5uB-5vhsV:
undetectable		 6f5uA-5vhsV:
10.42
6f5uB-5vhsV:
9.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bb9 4-AMINO-4-DEOXYCHORI
SMATE LYASE

(Salmonella
enterica) 		no annotation 5 VAL A 226
ALA A 225
LEU A 163
LEU A 165
LEU A 179
 None
 0.97A 6f5uA-6bb9A:
undetectable
6f5uB-6bb9A:
undetectable		 6f5uA-6bb9A:
14.71
6f5uB-6bb9A:
15.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6f6s ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1

(Zaire
ebolavirus) 		no annotation 5 ARG A  64
VAL A  66
ALA A 101
LEU A 184
LEU A 186
 CXQ  A 507 (-3.6A)
None
CXQ  A 507 (-3.6A)
None
None
 0.31A 6f5uA-6f6sA:
35.9
6f5uB-6f6sA:
undetectable		 6f5uA-6f6sA:
100.00
6f5uB-6f6sA:
10.00