SIMILAR PATTERNS OF AMINO ACIDS FOR 6EXI_C_ADNC502

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tj7 ARGININOSUCCINATE
LYASE

(Escherichia
coli) 		PF00206
(Lyase_1)
PF14698
(ASL_C2) 		5 LEU A 103
HIS A 104
ASP A  33
LEU A   3
HIS A  85
 None
 1.43A 6exiC-1tj7A:
undetectable		 6exiC-1tj7A:
12.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v8b ADENOSYLHOMOCYSTEINA
SE

(Plasmodium
falciparum) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		8 LEU A  53
HIS A  54
THR A  56
ASP A 234
ASN A 391
LEU A 392
HIS A 398
MET A 403
 None
ADN  A 502 (-4.1A)
ADN  A 502 (-3.0A)
ADN  A 502 (-2.8A)
NAD  A 501 (-3.0A)
ADN  A 502 ( 4.9A)
ADN  A 502 ( 3.5A)
ADN  A 502 (-3.6A)
 0.31A 6exiC-1v8bA:
55.8		 6exiC-1v8bA:
11.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gj4 GLYCOGEN
PHOSPHORYLASE,
MUSCLE FORM

(Oryctolagus
cuniculus) 		PF00343
(Phosphorylase) 		5 THR A 671
THR A 668
ASN A 284
LEU A 380
HIS A 571
 None
 1.15A 6exiC-2gj4A:
4.9		 6exiC-2gj4A:
7.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hxv DIAMINOHYDROXYPHOSPH
ORIBOSYLAMINOPYRIMID
INE DEAMINASE/
5-AMINO-6-(5-PHOSPHO
RIBOSYLAMINO)URACIL
REDUCTASE

(Thermotoga
maritima) 		PF00383
(dCMP_cyt_deam_1)
PF01872
(RibD_C) 		5 HIS A  49
ASP A 104
ASN A 106
HIS A  79
ASN A  23
 ZN  A 500 (-3.2A)
None
None
None
None
 1.34A 6exiC-2hxvA:
undetectable		 6exiC-2hxvA:
16.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nux 2-KETO-3-DEOXYGLUCON
ATE/2-KETO-3-DEOXY-6
-PHOSPHO GLUCONATE
ALDOLASE

(Sulfolobus
acidocaldarius) 		PF00701
(DHDPS) 		5 LEU A  68
THR A  65
ASN A 198
LEU A  22
HIS A  25
 None
 1.33A 6exiC-2nuxA:
undetectable		 6exiC-2nuxA:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xhg TYROCIDINE
SYNTHETASE A

(Brevibacillus
brevis) 		PF00668
(Condensation) 		5 GLN A  39
THR A 392
ASN A 412
ASN A 368
LEU A 370
 None
None
None
NA  A1469 ( 4.9A)
None
 1.49A 6exiC-2xhgA:
undetectable		 6exiC-2xhgA:
11.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ce6 ADENOSYLHOMOCYSTEINA
SE

(Mycobacterium
tuberculosis) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		6 LEU A  68
GLN A  73
THR A  74
ASP A 252
ASN A 253
MET A 421
 None
ADN  A 500 (-3.6A)
ADN  A 500 (-4.5A)
ADN  A 500 (-2.7A)
NAD  A 550 (-3.5A)
ADN  A 500 (-3.7A)
 0.83A 6exiC-3ce6A:
56.8		 6exiC-3ce6A:
60.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ce6 ADENOSYLHOMOCYSTEINA
SE

(Mycobacterium
tuberculosis) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		10 LEU A  68
HIS A  69
THR A  71
GLN A  73
THR A  74
ASP A 252
ASN A 409
LEU A 410
HIS A 416
MET A 421
 None
ADN  A 500 (-4.0A)
ADN  A 500 (-2.8A)
ADN  A 500 (-3.6A)
ADN  A 500 (-4.5A)
ADN  A 500 (-2.7A)
NAD  A 550 (-3.0A)
ADN  A 500 ( 4.8A)
ADN  A 500 ( 3.6A)
ADN  A 500 (-3.7A)
 0.27A 6exiC-3ce6A:
56.8		 6exiC-3ce6A:
60.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ce6 ADENOSYLHOMOCYSTEINA
SE

(Mycobacterium
tuberculosis) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		7 LEU A  68
HIS A  69
THR A  71
GLN A  73
THR A  74
HIS A 363
LEU A 410
 None
ADN  A 500 (-4.0A)
ADN  A 500 (-2.8A)
ADN  A 500 (-3.6A)
ADN  A 500 (-4.5A)
ADN  A 500 ( 3.7A)
ADN  A 500 ( 4.8A)
 0.99A 6exiC-3ce6A:
56.8		 6exiC-3ce6A:
60.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d6n DIHYDROOROTASE

(Aquifex
aeolicus) 		PF01979
(Amidohydro_1) 		5 THR A 124
ASP A 305
HIS A 180
ASN A  95
HIS A  63
 None
FLC  A 424 ( 2.7A)
FLC  A 424 (-4.0A)
FLC  A 424 (-3.6A)
ZN  A 423 ( 3.4A)
 1.27A 6exiC-3d6nA:
undetectable		 6exiC-3d6nA:
15.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3g1u ADENOSYLHOMOCYSTEINA
SE

(Leishmania
major) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		5 HIS A  52
THR A  54
ASN A 190
LEU A 343
HIS A 352
 ADN  A 438 (-4.0A)
ADN  A 438 (-2.8A)
NAD  A 439 (-3.2A)
NAD  A 439 ( 4.0A)
ADN  A 438 ( 3.6A)
 1.38A 6exiC-3g1uA:
54.1		 6exiC-3g1uA:
71.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3g1u ADENOSYLHOMOCYSTEINA
SE

(Leishmania
major) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		10 LEU A  51
HIS A  52
THR A  54
GLN A  56
THR A  57
ASN A 190
ASN A 345
LEU A 346
HIS A 352
MET A 357
 None
ADN  A 438 (-4.0A)
ADN  A 438 (-2.8A)
ADN  A 438 (-3.8A)
ADN  A 438 (-4.6A)
NAD  A 439 (-3.2A)
NAD  A 439 (-3.1A)
ADN  A 438 ( 4.8A)
ADN  A 438 ( 3.6A)
ADN  A 438 (-3.7A)
 0.51A 6exiC-3g1uA:
54.1		 6exiC-3g1uA:
71.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3g1u ADENOSYLHOMOCYSTEINA
SE

(Leishmania
major) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		7 LEU A  51
HIS A  52
THR A  54
GLN A  56
THR A  57
HIS A 300
LEU A 346
 None
ADN  A 438 (-4.0A)
ADN  A 438 (-2.8A)
ADN  A 438 (-3.8A)
ADN  A 438 (-4.6A)
ADN  A 438 ( 4.0A)
ADN  A 438 ( 4.8A)
 1.02A 6exiC-3g1uA:
54.1		 6exiC-3g1uA:
71.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3glq ADENOSYLHOMOCYSTEINA
SE

(Burkholderia
pseudomallei) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		5 HIS A  62
THR A  64
ASP A 233
ASN A 234
LEU A 385
 RAB  A 602 (-3.8A)
RAB  A 602 (-2.7A)
RAB  A 602 (-2.5A)
NAD  A 601 (-3.5A)
NAD  A 601 ( 4.1A)
 1.24A 6exiC-3glqA:
60.3		 6exiC-3glqA:
61.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3glq ADENOSYLHOMOCYSTEINA
SE

(Burkholderia
pseudomallei) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		5 LEU A  61
HIS A  62
ASP A 233
ASN A 234
LEU A 385
 None
RAB  A 602 (-3.8A)
RAB  A 602 (-2.5A)
NAD  A 601 (-3.5A)
NAD  A 601 ( 4.1A)
 1.32A 6exiC-3glqA:
60.3		 6exiC-3glqA:
61.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3glq ADENOSYLHOMOCYSTEINA
SE

(Burkholderia
pseudomallei) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		8 LEU A  61
HIS A  62
THR A  64
GLN A  66
THR A  67
ASP A 233
ASN A 234
MET A 399
 None
RAB  A 602 (-3.8A)
RAB  A 602 (-2.7A)
RAB  A 602 (-3.9A)
RAB  A 602 (-4.5A)
RAB  A 602 (-2.5A)
NAD  A 601 (-3.5A)
RAB  A 602 (-3.6A)
 0.80A 6exiC-3glqA:
60.3		 6exiC-3glqA:
61.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3glq ADENOSYLHOMOCYSTEINA
SE

(Burkholderia
pseudomallei) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		10 LEU A  61
HIS A  62
THR A  64
GLN A  66
THR A  67
ASP A 233
ASN A 387
LEU A 388
HIS A 394
MET A 399
 None
RAB  A 602 (-3.8A)
RAB  A 602 (-2.7A)
RAB  A 602 (-3.9A)
RAB  A 602 (-4.5A)
RAB  A 602 (-2.5A)
NAD  A 601 (-3.0A)
RAB  A 602 ( 4.7A)
NAD  A 601 ( 3.6A)
RAB  A 602 (-3.6A)
 0.28A 6exiC-3glqA:
60.3		 6exiC-3glqA:
61.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3glq ADENOSYLHOMOCYSTEINA
SE

(Burkholderia
pseudomallei) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		7 LEU A  61
HIS A  62
THR A  64
GLN A  66
THR A  67
HIS A 344
LEU A 388
 None
RAB  A 602 (-3.8A)
RAB  A 602 (-2.7A)
RAB  A 602 (-3.9A)
RAB  A 602 (-4.5A)
RAB  A 602 ( 3.5A)
RAB  A 602 ( 4.7A)
 0.98A 6exiC-3glqA:
60.3		 6exiC-3glqA:
61.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h9u ADENOSYLHOMOCYSTEINA
SE

(Trypanosoma
brucei) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		10 LEU A  51
HIS A  52
THR A  54
GLN A  56
THR A  57
ASP A 189
ASN A 345
LEU A 346
HIS A 352
MET A 357
 None
ADN  A 439 ( 4.7A)
ADN  A 439 (-2.7A)
ADN  A 439 (-3.6A)
ADN  A 439 (-4.7A)
NAD  A 438 ( 4.4A)
NAD  A 438 (-2.9A)
ADN  A 439 ( 4.7A)
ADN  A 439 ( 3.3A)
ADN  A 439 ( 3.7A)
 0.30A 6exiC-3h9uA:
56.4		 6exiC-3h9uA:
13.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h9u ADENOSYLHOMOCYSTEINA
SE

(Trypanosoma
brucei) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		7 LEU A  51
HIS A  52
THR A  54
GLN A  56
THR A  57
HIS A 300
LEU A 346
 None
ADN  A 439 ( 4.7A)
ADN  A 439 (-2.7A)
ADN  A 439 (-3.6A)
ADN  A 439 (-4.7A)
None
ADN  A 439 ( 4.7A)
 1.02A 6exiC-3h9uA:
56.4		 6exiC-3h9uA:
13.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h9u ADENOSYLHOMOCYSTEINA
SE

(Trypanosoma
brucei) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		7 LEU A  51
THR A  54
GLN A  56
THR A  57
ASP A 189
ASN A 190
MET A 357
 None
ADN  A 439 (-2.7A)
ADN  A 439 (-3.6A)
ADN  A 439 (-4.7A)
NAD  A 438 ( 4.4A)
NAD  A 438 (-3.4A)
ADN  A 439 ( 3.7A)
 0.83A 6exiC-3h9uA:
56.4		 6exiC-3h9uA:
13.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hdi PROCESSING PROTEASE

(Bacillus
halodurans) 		PF00675
(Peptidase_M16)
PF05193
(Peptidase_M16_C) 		5 LEU A 269
THR A 318
GLN A 315
THR A 317
LEU A 239
 None
 1.46A 6exiC-3hdiA:
undetectable		 6exiC-3hdiA:
12.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n58 ADENOSYLHOMOCYSTEINA
SE

(Brucella
abortus) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		6 LEU A  54
GLN A  59
THR A  60
ASP A 226
ASN A 227
MET A 392
 None
K  A   2 ( 3.3A)
ADN  A 500 (-4.6A)
ADN  A 500 ( 2.6A)
NAD  A 550 (-3.6A)
ADN  A 500 (-3.7A)
 0.91A 6exiC-3n58A:
32.3		 6exiC-3n58A:
14.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n58 ADENOSYLHOMOCYSTEINA
SE

(Brucella
abortus) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		10 LEU A  54
HIS A  55
THR A  57
GLN A  59
THR A  60
ASP A 226
ASN A 380
LEU A 381
HIS A 387
MET A 392
 None
ADN  A 500 (-4.0A)
ADN  A 500 (-2.8A)
K  A   2 ( 3.3A)
ADN  A 500 (-4.6A)
ADN  A 500 ( 2.6A)
NAD  A 550 (-3.0A)
ADN  A 500 ( 4.8A)
ADN  A 500 (-3.4A)
ADN  A 500 (-3.7A)
 0.26A 6exiC-3n58A:
32.3		 6exiC-3n58A:
14.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n58 ADENOSYLHOMOCYSTEINA
SE

(Brucella
abortus) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		7 LEU A  54
HIS A  55
THR A  57
GLN A  59
THR A  60
HIS A 337
LEU A 381
 None
ADN  A 500 (-4.0A)
ADN  A 500 (-2.8A)
K  A   2 ( 3.3A)
ADN  A 500 (-4.6A)
ADN  A 500 ( 3.6A)
ADN  A 500 ( 4.8A)
 1.00A 6exiC-3n58A:
32.3		 6exiC-3n58A:
14.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3one ADENOSYLHOMOCYSTEINA
SE

(Lupinus luteus) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		5 HIS A  62
THR A  64
ASP A 239
ASN A 240
LEU A 395
 ADE  A 506 (-4.6A)
ADE  A 506 (-2.8A)
NAD  A 501 ( 4.5A)
NAD  A 501 (-3.5A)
NAD  A 501 (-4.2A)
 1.26A 6exiC-3oneA:
56.5		 6exiC-3oneA:
64.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3one ADENOSYLHOMOCYSTEINA
SE

(Lupinus luteus) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		8 LEU A  61
HIS A  62
THR A  64
GLN A  66
THR A  67
ASP A 239
ASN A 240
MET A 409
 None
ADE  A 506 (-4.6A)
ADE  A 506 (-2.8A)
ADE  A 506 (-3.8A)
ADE  A 506 (-4.5A)
NAD  A 501 ( 4.5A)
NAD  A 501 (-3.5A)
ADE  A 506 (-3.8A)
 0.93A 6exiC-3oneA:
56.5		 6exiC-3oneA:
64.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3one ADENOSYLHOMOCYSTEINA
SE

(Lupinus luteus) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		10 LEU A  61
HIS A  62
THR A  64
GLN A  66
THR A  67
ASP A 239
ASN A 397
LEU A 398
HIS A 404
MET A 409
 None
ADE  A 506 (-4.6A)
ADE  A 506 (-2.8A)
ADE  A 506 (-3.8A)
ADE  A 506 (-4.5A)
NAD  A 501 ( 4.5A)
NAD  A 501 (-3.0A)
ADE  A 506 ( 4.7A)
ADE  A 506 (-3.4A)
ADE  A 506 (-3.8A)
 0.53A 6exiC-3oneA:
56.5		 6exiC-3oneA:
64.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3one ADENOSYLHOMOCYSTEINA
SE

(Lupinus luteus) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		7 LEU A  61
HIS A  62
THR A  64
GLN A  66
THR A  67
HIS A 350
LEU A 398
 None
ADE  A 506 (-4.6A)
ADE  A 506 (-2.8A)
ADE  A 506 (-3.8A)
ADE  A 506 (-4.5A)
None
ADE  A 506 ( 4.7A)
 1.18A 6exiC-3oneA:
56.5		 6exiC-3oneA:
64.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dwq TRNA-SPLICING LIGASE
RTCB

(Pyrococcus
horikoshii) 		PF01139
(RtcB) 		5 HIS A  67
GLN A  46
THR A  43
ASN A 330
HIS A 404
 POP  A 509 (-3.7A)
None
None
MLI  A 503 (-4.1A)
5GP  A 501 (-3.0A)
 1.49A 6exiC-4dwqA:
undetectable		 6exiC-4dwqA:
11.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f7k LACCASE

(uncultured
bacterium) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 HIS A 378
GLN A 100
THR A  99
HIS A 421
HIS A 126
 None
 1.41A 6exiC-4f7kA:
undetectable		 6exiC-4f7kA:
12.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j7b POLO-LIKE KINASE

(Danio rerio) 		PF00069
(Pkinase) 		5 LEU A 223
THR A 146
ASN A 167
LEU A 168
HIS A 160
 None
 1.32A 6exiC-4j7bA:
undetectable		 6exiC-4j7bA:
16.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4lvc S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(SAHASE)

(Bradyrhizobium
elkanii) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		6 LEU A  57
GLN A  62
THR A  63
ASP A 231
ASN A 232
MET A 397
 None
NH4  A 502 ( 3.1A)
ADN  A 501 (-4.5A)
ADN  A 501 (-3.1A)
NAD  A 503 (-3.6A)
ADN  A 501 (-3.7A)
 0.90A 6exiC-4lvcA:
64.4		 6exiC-4lvcA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4lvc S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(SAHASE)

(Bradyrhizobium
elkanii) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		10 LEU A  57
HIS A  58
THR A  60
GLN A  62
THR A  63
ASP A 231
ASN A 385
LEU A 386
HIS A 392
MET A 397
 None
ADN  A 501 (-4.0A)
ADN  A 501 (-2.8A)
NH4  A 502 ( 3.1A)
ADN  A 501 (-4.5A)
ADN  A 501 (-3.1A)
NAD  A 503 (-3.1A)
ADN  A 501 ( 4.7A)
ADN  A 501 (-3.5A)
ADN  A 501 (-3.7A)
 0.29A 6exiC-4lvcA:
64.4		 6exiC-4lvcA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4lvc S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(SAHASE)

(Bradyrhizobium
elkanii) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		7 LEU A  57
HIS A  58
THR A  60
GLN A  62
THR A  63
HIS A 342
LEU A 386
 None
ADN  A 501 (-4.0A)
ADN  A 501 (-2.8A)
NH4  A 502 ( 3.1A)
ADN  A 501 (-4.5A)
ADN  A 501 ( 3.7A)
ADN  A 501 ( 4.7A)
 1.02A 6exiC-4lvcA:
64.4		 6exiC-4lvcA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zmh UNCHARACTERIZED
PROTEIN

(Saccharophagus
degradans) 		PF15979
(Glyco_hydro_115) 		5 LEU A 399
HIS A 282
ASP A 402
ASN A 404
HIS A 428
 None
None
None
ACT  A1007 (-3.6A)
PO4  A1001 (-3.9A)
 1.39A 6exiC-4zmhA:
undetectable		 6exiC-4zmhA:
6.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uq6 TARTRATE-RESISTANT
ACID PHOSPHATASE
TYPE 5

(Sus scrofa) 		PF00149
(Metallophos) 		5 HIS A 195
THR A 198
ASP A  14
ASN A  91
HIS A 186
 PO4  A 404 (-3.8A)
None
FE  A 402 ( 3.1A)
PO4  A 404 ( 2.6A)
FE  A 403 ( 3.4A)
 1.27A 6exiC-5uq6A:
undetectable		 6exiC-5uq6A:
15.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uq6 TARTRATE-RESISTANT
ACID PHOSPHATASE
TYPE 5

(Sus scrofa) 		PF00149
(Metallophos) 		5 HIS A 195
THR A 198
HIS A 223
ASN A  91
HIS A 186
 PO4  A 404 (-3.8A)
None
FE  A 402 (-3.4A)
PO4  A 404 ( 2.6A)
FE  A 403 ( 3.4A)
 1.38A 6exiC-5uq6A:
undetectable		 6exiC-5uq6A:
15.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5utu ADENOSYLHOMOCYSTEINA
SE

(Cryptosporidium
parvum) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		9 LEU A  52
HIS A  53
THR A  55
THR A  58
ASP A 245
ASN A 403
LEU A 404
HIS A 410
MET A 415
 None
SAH  A 502 (-4.0A)
SAH  A 502 (-2.7A)
SAH  A 502 (-4.2A)
SAH  A 502 (-2.8A)
NAD  A 501 (-2.9A)
SAH  A 502 ( 4.7A)
SAH  A 502 ( 3.5A)
SAH  A 502 (-3.6A)
 0.32A 6exiC-5utuA:
53.6		 6exiC-5utuA:
9.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5utu ADENOSYLHOMOCYSTEINA
SE

(Cryptosporidium
parvum) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		5 LEU A  52
THR A  58
ASP A 245
ASN A 246
MET A 415
 None
SAH  A 502 (-4.2A)
SAH  A 502 (-2.8A)
NAD  A 501 (-3.5A)
SAH  A 502 (-3.6A)
 0.87A 6exiC-5utuA:
53.6		 6exiC-5utuA:
9.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v96 S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE

(Naegleria
fowleri) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		9 LEU A  58
HIS A  59
THR A  61
THR A  64
ASP A 231
ASN A 388
LEU A 389
HIS A 395
MET A 400
 None
ADN  A 502 ( 3.9A)
ADN  A 502 (-2.9A)
ADN  A 502 (-4.4A)
ADN  A 502 (-2.8A)
NAD  A 501 (-3.1A)
ADN  A 502 ( 4.7A)
ADN  A 502 ( 3.4A)
ADN  A 502 (-3.8A)
 0.26A 6exiC-5v96A:
58.0		 6exiC-5v96A:
13.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v96 S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE

(Naegleria
fowleri) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		5 LEU A  58
THR A  64
ASP A 231
ASN A 232
MET A 400
 None
ADN  A 502 (-4.4A)
ADN  A 502 (-2.8A)
NAD  A 501 (-3.5A)
ADN  A 502 (-3.8A)
 0.83A 6exiC-5v96A:
58.0		 6exiC-5v96A:
13.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vbl APELIN
RECEPTOR,RUBREDOXIN,
APELIN RECEPTOR
CHIMERA

(Clostridium
pasteurianum;
Homo sapiens) 		PF00001
(7tm_1)
PF00301
(Rubredoxin) 		5 LEU B 120
THR B 256
ASP B  75
ASN B  46
LEU B 308
 None
 1.23A 6exiC-5vblB:
undetectable		 6exiC-5vblB:
13.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w4b ADENOSYLHOMOCYSTEINA
SE

(Homo sapiens) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		5 LEU A  54
HIS A  55
THR A  57
THR A  60
ASP A 190
 None
9W4  A 502 (-3.7A)
9W4  A 502 (-2.9A)
None
NAD  A 501 (-4.1A)
 0.55A 6exiC-5w4bA:
48.4		 6exiC-5w4bA:
12.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w4b ADENOSYLHOMOCYSTEINA
SE

(Homo sapiens) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		5 LEU A  54
HIS A  55
THR A  57
THR A  60
MET A 358
 None
9W4  A 502 (-3.7A)
9W4  A 502 (-2.9A)
None
9W4  A 502 (-3.6A)
 0.17A 6exiC-5w4bA:
48.4		 6exiC-5w4bA:
12.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6aph ADENOSYLHOMOCYSTEINA
SE

(Elizabethkingia
anophelis) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		7 LEU A  57
HIS A  58
GLN A  62
THR A  63
ASP A 195
ASN A 196
MET A 363
 None
ADN  A 501 (-3.9A)
ADN  A 501 (-3.8A)
ADN  A 501 (-4.5A)
ADN  A 501 (-2.7A)
NAD  A 500 (-3.5A)
ADN  A 501 (-3.7A)
 0.85A 6exiC-6aphA:
29.4		 6exiC-6aphA:
69.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6aph ADENOSYLHOMOCYSTEINA
SE

(Elizabethkingia
anophelis) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		10 LEU A  57
HIS A  58
THR A  60
GLN A  62
THR A  63
ASP A 195
ASN A 351
LEU A 352
HIS A 358
MET A 363
 None
ADN  A 501 (-3.9A)
ADN  A 501 (-2.8A)
ADN  A 501 (-3.8A)
ADN  A 501 (-4.5A)
ADN  A 501 (-2.7A)
NAD  A 500 (-3.1A)
ADN  A 501 ( 4.8A)
ADN  A 501 ( 3.5A)
ADN  A 501 (-3.7A)
 0.24A 6exiC-6aphA:
29.4		 6exiC-6aphA:
69.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6aph ADENOSYLHOMOCYSTEINA
SE

(Elizabethkingia
anophelis) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		7 LEU A  57
HIS A  58
THR A  60
GLN A  62
THR A  63
HIS A 306
LEU A 352
 None
ADN  A 501 (-3.9A)
ADN  A 501 (-2.8A)
ADN  A 501 (-3.8A)
ADN  A 501 (-4.5A)
ADN  A 501 ( 3.7A)
ADN  A 501 ( 4.8A)
 1.02A 6exiC-6aphA:
29.4		 6exiC-6aphA:
69.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f3m -

(-) 		no annotation 7 HIS B  61
THR B  63
GLN B  65
THR B  66
ASP B 198
ASN B 199
MET B 387
 ADN  B 502 ( 4.0A)
ADN  B 502 (-2.8A)
K  B 504 ( 3.0A)
ADN  B 502 (-4.6A)
ADN  B 502 (-2.7A)
NAD  B 501 (-3.5A)
ADN  B 502 (-3.7A)
 0.87A 6exiC-6f3mB:
52.4		 6exiC-6f3mB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f3m -

(-) 		no annotation 9 HIS B  61
THR B  63
GLN B  65
THR B  66
ASP B 198
ASN B 375
LEU B 376
HIS B 382
MET B 387
 ADN  B 502 ( 4.0A)
ADN  B 502 (-2.8A)
K  B 504 ( 3.0A)
ADN  B 502 (-4.6A)
ADN  B 502 (-2.7A)
NAD  B 501 (-3.0A)
ADN  B 502 ( 4.8A)
ADN  B 502 (-3.4A)
ADN  B 502 (-3.7A)
 0.29A 6exiC-6f3mB:
52.4		 6exiC-6f3mB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f3m -

(-) 		no annotation 6 HIS B  61
THR B  63
GLN B  65
THR B  66
HIS B 323
LEU B 376
 ADN  B 502 ( 4.0A)
ADN  B 502 (-2.8A)
K  B 504 ( 3.0A)
ADN  B 502 (-4.6A)
ZN  B 505 (-3.2A)
ADN  B 502 ( 4.8A)
 0.97A 6exiC-6f3mB:
52.4		 6exiC-6f3mB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6g2j NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
4

(Mus musculus) 		no annotation 5 THR M 414
GLN M 415
THR M 413
ASN M 366
LEU M 282
 None
 1.40A 6exiC-6g2jM:
undetectable		 6exiC-6g2jM:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gbn -

(-) 		no annotation 10 LEU A  55
HIS A  56
THR A  58
GLN A  60
THR A  61
ASP A 193
ASN A 349
LEU A 350
HIS A 356
MET A 361
 None
ADN  A 501 (-3.9A)
ADN  A 501 (-2.8A)
NA  A 503 ( 3.2A)
ADN  A 501 (-4.6A)
ADN  A 501 (-2.7A)
NAD  A 502 (-3.1A)
ADN  A 501 ( 4.7A)
ADN  A 501 (-3.4A)
ADN  A 501 (-3.6A)
 0.21A 6exiC-6gbnA:
30.6		 6exiC-6gbnA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gbn -

(-) 		no annotation 7 LEU A  55
HIS A  56
THR A  58
GLN A  60
THR A  61
HIS A 304
LEU A 350
 None
ADN  A 501 (-3.9A)
ADN  A 501 (-2.8A)
NA  A 503 ( 3.2A)
ADN  A 501 (-4.6A)
ADN  A 501 ( 3.6A)
ADN  A 501 ( 4.7A)
 1.00A 6exiC-6gbnA:
30.6		 6exiC-6gbnA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gbn -

(-) 		no annotation 5 LEU A  55
THR A  61
ASP A 193
ASN A 194
MET A 361
 None
ADN  A 501 (-4.6A)
ADN  A 501 (-2.7A)
NAD  A 502 (-3.5A)
ADN  A 501 (-3.6A)
 0.83A 6exiC-6gbnA:
30.6		 6exiC-6gbnA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1aql BILE-SALT ACTIVATED
LIPASE

(Bos taurus) 		PF00135
(COesterase) 		3 LEU A 190
GLY A 192
PHE A 109
 None
 0.67A 6exiC-1aqlA:
3.4		 6exiC-1aqlA:
11.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b3b PROTEIN (GLUTAMATE
DEHYDROGENASE)

(Thermotoga
maritima) 		PF00208
(ELFV_dehydrog)
PF02812
(ELFV_dehydrog_N) 		3 LEU A  85
GLY A  69
PHE A 126
 None
 0.65A 6exiC-1b3bA:
10.5		 6exiC-1b3bA:
11.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b41 ACETYLCHOLINESTERASE

(Homo sapiens) 		PF00135
(COesterase) 		3 LEU A 199
GLY A 201
PHE A 123
 None
 0.67A 6exiC-1b41A:
undetectable		 6exiC-1b41A:
12.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c2o ACETYLCHOLINESTERASE

(Electrophorus
electricus) 		PF00135
(COesterase) 		3 LEU A 199
GLY A 201
PHE A 123
 None
 0.66A 6exiC-1c2oA:
3.4		 6exiC-1c2oA:
12.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ck7 PROTEIN (GELATINASE
A)

(Homo sapiens) 		PF00040
(fn2)
PF00045
(Hemopexin)
PF00413
(Peptidase_M10)
PF01471
(PG_binding_1) 		3 LEU A  83
GLY A 505
PHE A 512
 None
 0.66A 6exiC-1ck7A:
undetectable		 6exiC-1ck7A:
8.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dqz PROTEIN (ANTIGEN
85-C)

(Mycobacterium
tuberculosis) 		PF00756
(Esterase) 		3 LEU A 198
GLY A 250
PHE A 254
 None
 0.66A 6exiC-1dqzA:
4.1		 6exiC-1dqzA:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gcy GLUCAN
1,4-ALPHA-MALTOTETRA
HYDROLASE

(Pseudomonas
stutzeri) 		PF00128
(Alpha-amylase)
PF09081
(DUF1921) 		3 LEU A 274
GLY A 327
PHE A 215
 None
 0.52A 6exiC-1gcyA:
undetectable		 6exiC-1gcyA:
10.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gyd ARABINAN
ENDO-1,5-ALPHA-L-ARA
BINOSIDASE A

(Cellvibrio
japonicus) 		PF04616
(Glyco_hydro_43) 		3 LEU B 107
GLY B 122
PHE B  89
 None
 0.67A 6exiC-1gydB:
undetectable		 6exiC-1gydB:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h74 HOMOSERINE KINASE

(Methanocaldococcus
jannaschii) 		PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C) 		3 LEU A  18
GLY A 222
PHE A 168
 None
 0.60A 6exiC-1h74A:
undetectable		 6exiC-1h74A:
14.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hv6 ALGINATE LYASE

(Sphingomonas
sp.) 		PF05426
(Alginate_lyase) 		3 LEU A 217
GLY A 197
PHE A 148
 None
 0.60A 6exiC-1hv6A:
undetectable		 6exiC-1hv6A:
11.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jzt HYPOTHETICAL 27.5
KDA PROTEIN IN
SPX19-GCR2
INTERGENIC REGION

(Saccharomyces
cerevisiae) 		PF03853
(YjeF_N) 		3 LEU A  31
GLY A 219
PHE A 232
 None
 0.56A 6exiC-1jztA:
4.2		 6exiC-1jztA:
13.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kob TWITCHIN

(Aplysia
californica) 		PF00069
(Pkinase) 		3 LEU A 297
GLY A 237
PHE A 269
 None
 0.57A 6exiC-1kobA:
undetectable		 6exiC-1kobA:
13.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kp2 ARGININOSUCCINATE
SYNTHETASE

(Escherichia
coli) 		PF00764
(Arginosuc_synth) 		3 LEU A 197
GLY A 295
PHE A 240
 None
 0.65A 6exiC-1kp2A:
3.0		 6exiC-1kp2A:
12.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kpi CYCLOPROPANE-FATTY-A
CYL-PHOSPHOLIPID
SYNTHASE 2

(Mycobacterium
tuberculosis) 		PF02353
(CMAS) 		3 LEU A 103
GLY A  80
PHE A 169
 SAH  A 900 (-4.4A)
SAH  A 900 (-3.3A)
None
 0.43A 6exiC-1kpiA:
3.3		 6exiC-1kpiA:
15.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l6j MATRIX
METALLOPROTEINASE-9

(Homo sapiens) 		PF00040
(fn2)
PF00413
(Peptidase_M10)
PF01471
(PG_binding_1) 		3 LEU A 147
GLY A 404
PHE A 204
 None
 0.65A 6exiC-1l6jA:
undetectable		 6exiC-1l6jA:
12.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1or8 PROTEIN ARGININE
N-METHYLTRANSFERASE
1

(Rattus
norvegicus) 		PF13649
(Methyltransf_25) 		3 LEU A 156
GLY A 147
PHE A 283
 None
 0.66A 6exiC-1or8A:
5.9		 6exiC-1or8A:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oy1 PUTATIVE SIGMA
CROSS-REACTING
PROTEIN 27A

(Escherichia
coli) 		no annotation 3 LEU A 218
GLY A 131
PHE A 148
 None
 0.67A 6exiC-1oy1A:
4.5		 6exiC-1oy1A:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1poj ISOASPARTYL
DIPEPTIDASE

(Escherichia
coli) 		PF01979
(Amidohydro_1) 		3 LEU A 116
GLY A  73
PHE A 307
 None
 0.59A 6exiC-1pojA:
undetectable		 6exiC-1pojA:
13.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qye ENDOPLASMIN

(Canis lupus) 		PF00183
(HSP90)
PF02518
(HATPase_c) 		3 LEU A 159
GLY A 164
PHE A 203
 None
 0.54A 6exiC-1qyeA:
undetectable		 6exiC-1qyeA:
14.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r53 CHORISMATE SYNTHASE

(Saccharomyces
cerevisiae) 		PF01264
(Chorismate_synt) 		3 LEU A 226
GLY A 293
PHE A 255
 None
 0.58A 6exiC-1r53A:
undetectable		 6exiC-1r53A:
13.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sfr ANTIGEN 85-A

(Mycobacterium
tuberculosis) 		PF00756
(Esterase) 		3 LEU A 200
GLY A 252
PHE A 256
 None
 0.57A 6exiC-1sfrA:
3.7		 6exiC-1sfrA:
16.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u5k HYPOTHETICAL PROTEIN

(Deinococcus
radiodurans) 		PF02565
(RecO_C)
PF11967
(RecO_N) 		3 LEU A  76
GLY A  57
PHE A 113
 None
 0.65A 6exiC-1u5kA:
undetectable		 6exiC-1u5kA:
15.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uf3 HYPOTHETICAL PROTEIN
TT1561

(Thermus
thermophilus) 		PF14582
(Metallophos_3) 		3 LEU A 154
GLY A  40
PHE A  56
 None
 0.61A 6exiC-1uf3A:
undetectable		 6exiC-1uf3A:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uik ALPHA PRIME SUBUNIT
OF BETA-CONGLYCININ

(Glycine max) 		PF00190
(Cupin_1) 		3 LEU A 233
GLY A 236
PHE A 481
 None
 0.60A 6exiC-1uikA:
undetectable		 6exiC-1uikA:
11.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1us4 PUTATIVE GLUR0
LIGAND BINDING CORE

(Thermus
thermophilus) 		PF16868
(NMT1_3) 		3 LEU A 282
GLY A 287
PHE A 306
 None
 0.64A 6exiC-1us4A:
undetectable		 6exiC-1us4A:
13.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v26 LONG-CHAIN-FATTY-ACI
D-COA SYNTHETASE

(Thermus
thermophilus) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		3 LEU A 216
GLY A 244
PHE A  90
 None
 0.59A 6exiC-1v26A:
4.6		 6exiC-1v26A:
9.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v8b ADENOSYLHOMOCYSTEINA
SE

(Plasmodium
falciparum) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		3 LEU A 389
GLY A 397
PHE A 407
 NAD  A 501 ( 3.8A)
ADN  A 502 ( 3.7A)
None
 0.26A 6exiC-1v8bA:
55.8		 6exiC-1v8bA:
11.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w5d PENICILLIN-BINDING
PROTEIN

(Bacillus
subtilis) 		PF02113
(Peptidase_S13) 		3 LEU A 344
GLY A 349
PHE A 295
 None
 0.60A 6exiC-1w5dA:
undetectable		 6exiC-1w5dA:
9.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wyr RHO GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 6

(Homo sapiens) 		PF00307
(CH) 		3 LEU A  52
GLY A  80
PHE A  89
 None
 0.66A 6exiC-1wyrA:
undetectable		 6exiC-1wyrA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xc6 BETA-GALACTOSIDASE

(Penicillium sp.) 		PF01301
(Glyco_hydro_35)
PF10435
(BetaGal_dom2)
PF13363
(BetaGal_dom3)
PF13364
(BetaGal_dom4_5) 		3 LEU A 805
GLY A 752
PHE A 733
 None
 0.64A 6exiC-1xc6A:
undetectable		 6exiC-1xc6A:
6.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xrs D-LYSINE
5,6-AMINOMUTASE
ALPHA SUBUNIT

(Acetoanaerobium
sticklandii) 		PF09043
(Lys-AminoMut_A) 		3 LEU A 336
GLY A 296
PHE A 482
 None
PLP  B 801 ( 4.3A)
None
 0.61A 6exiC-1xrsA:
undetectable		 6exiC-1xrsA:
12.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xs5 MEMBRANE LIPOPROTEIN
TPN32

(Treponema
pallidum) 		PF03180
(Lipoprotein_9) 		3 LEU A 184
GLY A 190
PHE A 102
 None
 0.57A 6exiC-1xs5A:
undetectable		 6exiC-1xs5A:
15.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ye8 HYPOTHETICAL UPF0334
KINASE-LIKE PROTEIN
AQ_1292

(Aquifex
aeolicus) 		PF03266
(NTPase_1) 		3 LEU A 145
GLY A 109
PHE A  31
 None
 0.65A 6exiC-1ye8A:
undetectable		 6exiC-1ye8A:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z45 GAL10 BIFUNCTIONAL
PROTEIN

(Saccharomyces
cerevisiae) 		PF01263
(Aldose_epim)
PF16363
(GDP_Man_Dehyd) 		3 LEU A 524
GLY A 522
PHE A 464
 None
 0.67A 6exiC-1z45A:
8.6		 6exiC-1z45A:
9.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zh8 OXIDOREDUCTASE

(Thermotoga
maritima) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		3 LEU A  66
GLY A  10
PHE A 286
 None
 0.64A 6exiC-1zh8A:
4.5		 6exiC-1zh8A:
13.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zno HYPOTHETICAL UPF0244
PROTEIN VC0702

(Vibrio cholerae) 		PF01931
(NTPase_I-T) 		3 LEU A  65
GLY A  83
PHE A 174
 None
 0.57A 6exiC-1znoA:
undetectable		 6exiC-1znoA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zws DAP-KINASE RELATED
PROTEIN 1

(Homo sapiens) 		PF00069
(Pkinase) 		3 LEU A 264
GLY A 204
PHE A 236
 None
 0.58A 6exiC-1zwsA:
undetectable		 6exiC-1zwsA:
14.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zzg GLUCOSE-6-PHOSPHATE
ISOMERASE

(Thermus
thermophilus) 		PF00342
(PGI) 		3 LEU A   2
GLY A 212
PHE A  88
 None
 0.59A 6exiC-1zzgA:
2.7		 6exiC-1zzgA:
12.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a1u ELECTRON TRANSFER
FLAVOPROTEIN
BETA-SUBUNIT

(Homo sapiens) 		PF01012
(ETF) 		3 LEU B 222
GLY B 100
PHE B 141
 None
 0.58A 6exiC-2a1uB:
undetectable		 6exiC-2a1uB:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a2a DEATH-ASSOCIATED
PROTEIN KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		3 LEU A 264
GLY A 204
PHE A 236
 None
 0.65A 6exiC-2a2aA:
undetectable		 6exiC-2a2aA:
13.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2akp ATP-DEPENDENT
MOLECULAR CHAPERONE
HSP82

(Saccharomyces
cerevisiae) 		PF00183
(HSP90)
PF02518
(HATPase_c) 		3 LEU A  89
GLY A  94
PHE A 128
 None
 0.66A 6exiC-2akpA:
undetectable		 6exiC-2akpA:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2amg 1,4-ALPHA-D-GLUCAN
MALTOTETRAHYDROLASE

(Pseudomonas
stutzeri) 		PF00128
(Alpha-amylase)
PF09081
(DUF1921) 		3 LEU A 274
GLY A 327
PHE A 215
 None
 0.51A 6exiC-2amgA:
undetectable		 6exiC-2amgA:
11.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b39 C3

(Bos taurus) 		PF00207
(A2M)
PF01759
(NTR)
PF01821
(ANATO)
PF01835
(A2M_N)
PF07677
(A2M_recep)
PF07678
(A2M_comp)
PF07703
(A2M_N_2)
PF10569
(Thiol-ester_cl) 		3 LEU A 197
GLY A1051
PHE A1272
 None
 0.62A 6exiC-2b39A:
undetectable		 6exiC-2b39A:
4.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bex RIBONUCLEASE
INHIBITOR

(Homo sapiens) 		PF13516
(LRR_6) 		3 LEU A 104
GLY A 135
PHE A 171
 None
GOL  A1461 ( 4.1A)
None
 0.51A 6exiC-2bexA:
undetectable		 6exiC-2bexA:
10.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bre ATP-DEPENDENT
MOLECULAR CHAPERONE
HSP82

(Saccharomyces
cerevisiae) 		PF00183
(HSP90)
PF02518
(HATPase_c) 		3 LEU A  89
GLY A  94
PHE A 128
 None
 0.62A 6exiC-2breA:
undetectable		 6exiC-2breA:
13.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c1z UDP-GLUCOSE
FLAVONOID 3-O
GLYCOSYLTRANSFERASE

(Vitis vinifera) 		PF00201
(UDPGT) 		3 LEU A 377
GLY A 143
PHE A 121
 None
None
KMP  A1456 (-4.5A)
 0.58A 6exiC-2c1zA:
5.7		 6exiC-2c1zA:
10.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cfh TRAFFICKING PROTEIN
PARTICLE COMPLEX
SUBUNIT 6B

(Homo sapiens) 		PF04051
(TRAPP) 		3 LEU C  36
GLY C  40
PHE C  77
 CSO  C  32 ( 3.8A)
None
None
 0.59A 6exiC-2cfhC:
undetectable		 6exiC-2cfhC:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d4z CHLORIDE CHANNEL
PROTEIN

(Torpedo
marmorata) 		no annotation 3 LEU A 738
GLY A 743
PHE A 570
 None
 0.55A 6exiC-2d4zA:
undetectable		 6exiC-2d4zA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eaa 7S GLOBULIN-3

(Vigna angularis) 		PF00190
(Cupin_1) 		3 LEU A 106
GLY A 109
PHE A 353
 None
 0.61A 6exiC-2eaaA:
undetectable		 6exiC-2eaaA:
10.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fja ADENYLYLSULFATE
REDUCTASE, SUBUNIT A
ADENYLYLSULFATE
REDUCTASE, SUBUNIT B

(Archaeoglobus
fulgidus;
Archaeoglobus
fulgidus) 		PF00890
(FAD_binding_2)
PF02910
(Succ_DH_flav_C)
PF12139
(APS-reductase_C)
PF13187
(Fer4_9) 		3 LEU A  54
GLY A 166
PHE B 815
 None
 0.65A 6exiC-2fjaA:
undetectable		 6exiC-2fjaA:
9.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fv0 UNSATURATED
GLUCURONYL HYDROLASE

(Bacillus sp.
GL1) 		PF07470
(Glyco_hydro_88) 		3 LEU A 184
GLY A 222
PHE A  91
 None
None
GAD  A 404 (-4.4A)
 0.57A 6exiC-2fv0A:
undetectable		 6exiC-2fv0A:
13.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hw6 MAP
KINASE-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		3 LEU A 322
GLY A 247
PHE A 294
 None
 0.61A 6exiC-2hw6A:
undetectable		 6exiC-2hw6A:
13.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hx5 HYPOTHETICAL PROTEIN

(Prochlorococcus
marinus) 		PF13279
(4HBT_2) 		3 LEU A 140
GLY A 135
PHE A  52
 None
None
ETX  A 152 (-4.3A)
 0.66A 6exiC-2hx5A:
undetectable		 6exiC-2hx5A:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ijl MOLYBDENUM-BINDING
TRANSCRIPTIONAL
REPRESSOR

(Agrobacterium
fabrum) 		PF00126
(HTH_1) 		3 LEU A  12
GLY A  23
PHE A  64
 None
SO4  A 203 (-3.2A)
None
 0.66A 6exiC-2ijlA:
undetectable		 6exiC-2ijlA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2in5 HYPOTHETICAL
LIPOPROTEIN YMCC

(Escherichia
coli) 		PF11102
(YjbF) 		3 LEU A  77
GLY A  74
PHE A 130
 None
 0.65A 6exiC-2in5A:
undetectable		 6exiC-2in5A:
16.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iuc ALKALINE PHOSPHATASE

(Antarctic
bacterium TAB5) 		PF00245
(Alk_phosphatase) 		3 LEU B 163
GLY B 212
PHE B 230
 None
 0.62A 6exiC-2iucB:
undetectable		 6exiC-2iucB:
14.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j3t TRAFFICKING PROTEIN
PARTICLE COMPLEX
SUBUNIT 6A

(Homo sapiens) 		PF04051
(TRAPP) 		3 LEU B  37
GLY B  41
PHE B  78
 None
 0.59A 6exiC-2j3tB:
undetectable		 6exiC-2j3tB:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lml PUTATIVE ACYL
CARRIER PROTEIN

(Geobacter
metallireducens) 		PF00550
(PP-binding) 		3 LEU A  22
GLY A  66
PHE A  54
 None
 0.59A 6exiC-2lmlA:
undetectable		 6exiC-2lmlA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lyd DECAPPING PROTEIN 1

(Drosophila
melanogaster) 		PF06058
(DCP1) 		3 LEU A 124
GLY A 118
PHE A  52
 None
 0.61A 6exiC-2lydA:
undetectable		 6exiC-2lydA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mvz PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE

(Geobacillus
kaustophilus) 		PF00160
(Pro_isomerase) 		3 LEU A  43
GLY A  56
PHE A 118
 None
 0.67A 6exiC-2mvzA:
undetectable		 6exiC-2mvzA:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2n3l SERINE/ARGININE-RICH
PROTEIN 1,
PFSR1-RRM1

(Plasmodium
falciparum) 		PF00076
(RRM_1) 		3 LEU A  76
GLY A  13
PHE A  28
 None
 0.58A 6exiC-2n3lA:
undetectable		 6exiC-2n3lA:
15.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o1w ENDOPLASMIN

(Canis lupus) 		PF00183
(HSP90)
PF02518
(HATPase_c) 		3 LEU A 159
GLY A 164
PHE A 203
 None
 0.60A 6exiC-2o1wA:
undetectable		 6exiC-2o1wA:
10.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o2c GLUCOSE-6-PHOSPHATE
ISOMERASE,
GLYCOSOMAL

(Trypanosoma
brucei) 		PF00342
(PGI) 		3 LEU A 349
GLY A 334
PHE A 231
 None
 0.65A 6exiC-2o2cA:
3.6		 6exiC-2o2cA:
10.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oxt NUCLEOSIDE-2'-O-METH
YLTRANSFERASE

(Meaban virus) 		PF01728
(FtsJ) 		3 LEU A 260
GLY A 121
PHE A 127
 None
 0.56A 6exiC-2oxtA:
2.2		 6exiC-2oxtA:
14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pg8 DPGC

(Streptomyces
toyocaensis) 		PF00378
(ECH_1) 		3 LEU A 215
GLY A 213
PHE A 156
 None
 0.65A 6exiC-2pg8A:
undetectable		 6exiC-2pg8A:
10.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qma DIAMINOBUTYRATE-PYRU
VATE TRANSAMINASE
AND
L-2,4-DIAMINOBUTYRAT
E DECARBOXYLASE

(Vibrio
parahaemolyticus) 		PF00282
(Pyridoxal_deC) 		3 LEU A 616
GLY A 622
PHE A 784
 None
 0.59A 6exiC-2qmaA:
undetectable		 6exiC-2qmaA:
10.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rfb CYTOCHROME P450

(Picrophilus
torridus) 		PF00067
(p450) 		3 LEU A 309
GLY A 198
PHE A 130
 HEM  A 410 ( 4.5A)
HEM  A 410 (-3.1A)
None
 0.52A 6exiC-2rfbA:
undetectable		 6exiC-2rfbA:
13.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uv8 FATTY ACID SYNTHASE
SUBUNIT BETA (FAS1)

(Saccharomyces
cerevisiae) 		PF00698
(Acyl_transf_1)
PF01575
(MaoC_dehydratas)
PF08354
(DUF1729)
PF13452
(MaoC_dehydrat_N)
PF16073
(SAT) 		3 LEU G1809
GLY G1835
PHE G1698
 None
 0.64A 6exiC-2uv8G:
undetectable		 6exiC-2uv8G:
3.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vd9 ALANINE RACEMASE

(Bacillus
anthracis) 		PF00842
(Ala_racemase_C)
PF01168
(Ala_racemase_N) 		3 LEU A 250
GLY A 338
PHE A 300
 None
 0.62A 6exiC-2vd9A:
undetectable		 6exiC-2vd9A:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV

(Homo sapiens) 		PF00069
(Pkinase) 		3 LEU A 289
GLY A 228
PHE A 261
 None
 0.58A 6exiC-2w4oA:
undetectable		 6exiC-2w4oA:
14.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y7j PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM

(Homo sapiens) 		PF00069
(Pkinase) 		3 LEU A 280
GLY A 220
PHE A 252
 None
 0.61A 6exiC-2y7jA:
undetectable		 6exiC-2y7jA:
11.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yab DEATH-ASSOCIATED
PROTEIN KINASE 2

(Mus musculus) 		PF00069
(Pkinase) 		3 LEU A 264
GLY A 204
PHE A 236
 None
 0.53A 6exiC-2yabA:
undetectable		 6exiC-2yabA:
13.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z0f PUTATIVE
PHOSPHOGLUCOMUTASE

(Thermus
thermophilus) 		PF00408
(PGM_PMM_IV)
PF02878
(PGM_PMM_I)
PF02879
(PGM_PMM_II)
PF02880
(PGM_PMM_III) 		3 LEU A  67
GLY A 124
PHE A  26
 None
 0.64A 6exiC-2z0fA:
undetectable		 6exiC-2z0fA:
9.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z36 CYTOCHROME P450 TYPE
COMPACTIN
3'',4''-HYDROXYLASE

(Nonomuraea
recticatena) 		PF00067
(p450) 		3 LEU A 361
GLY A 246
PHE A 174
 HEM  A 450 ( 4.9A)
HEM  A 450 ( 3.4A)
None
 0.66A 6exiC-2z36A:
undetectable		 6exiC-2z36A:
13.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zwr METALLO-BETA-LACTAMA
SE SUPERFAMILY
PROTEIN

(Thermus
thermophilus) 		PF00753
(Lactamase_B) 		3 LEU A  81
GLY A 128
PHE A 132
 None
 0.66A 6exiC-2zwrA:
undetectable		 6exiC-2zwrA:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a24 ALPHA-GALACTOSIDASE

(Bacteroides
thetaiotaomicron) 		PF10566
(Glyco_hydro_97)
PF14508
(GH97_N)
PF14509
(GH97_C) 		3 LEU A 530
GLY A 503
PHE A 338
 None
 0.61A 6exiC-3a24A:
undetectable		 6exiC-3a24A:
9.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a5x FLAGELLIN

(Salmonella
enterica) 		PF00669
(Flagellin_N)
PF00700
(Flagellin_C)
PF08884
(Flagellin_D3) 		3 LEU A 266
GLY A 243
PHE A 202
 None
 0.62A 6exiC-3a5xA:
undetectable		 6exiC-3a5xA:
11.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a8t ADENYLATE
ISOPENTENYLTRANSFERA
SE

(Humulus lupulus) 		PF01715
(IPPT) 		3 LEU A  35
GLY A  37
PHE A 295
 None
 0.62A 6exiC-3a8tA:
undetectable		 6exiC-3a8tA:
12.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b8l UNCHARACTERIZED
PROTEIN

(Novosphingobium
aromaticivorans) 		PF13577
(SnoaL_4) 		3 LEU A 136
GLY A  47
PHE A  60
 None
 0.65A 6exiC-3b8lA:
undetectable		 6exiC-3b8lA:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b9j XANTHINE OXIDASE

(Bos taurus) 		PF00941
(FAD_binding_5)
PF03450
(CO_deh_flav_C) 		3 LEU B 257
GLY B 350
PHE B 389
 FAD  B 606 (-4.3A)
FAD  B 606 (-3.5A)
None
 0.67A 6exiC-3b9jB:
undetectable		 6exiC-3b9jB:
14.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bc9 ALPHA AMYLASE,
CATALYTIC REGION

(Halothermothrix
orenii) 		PF00128
(Alpha-amylase)
PF09154
(DUF1939) 		3 LEU A 429
GLY A 476
PHE A 376
 None
 0.60A 6exiC-3bc9A:
undetectable		 6exiC-3bc9A:
9.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bwm CATECHOL
O-METHYLTRANSFERASE

(Homo sapiens) 		PF01596
(Methyltransf_3) 		3 LEU A 198
GLY A 206
PHE A 139
 DNC  A 302 (-4.5A)
None
None
 0.57A 6exiC-3bwmA:
6.4		 6exiC-3bwmA:
15.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cue TRANSPORT PROTEIN
PARTICLE 22 KDA
SUBUNIT

(Saccharomyces
cerevisiae) 		PF04051
(TRAPP) 		3 LEU D 148
GLY D  60
PHE D  30
 None
 0.67A 6exiC-3cueD:
undetectable		 6exiC-3cueD:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e6e ALANINE RACEMASE

(Enterococcus
faecalis) 		PF00842
(Ala_racemase_C)
PF01168
(Ala_racemase_N) 		3 LEU A 247
GLY A 335
PHE A 297
 None
 0.61A 6exiC-3e6eA:
2.5		 6exiC-3e6eA:
13.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eni BACTERIOCHLOROPHYLL
A PROTEIN

(Chlorobaculum
tepidum) 		PF02327
(BChl_A) 		3 LEU A 294
GLY A 298
PHE A 306
 None
None
BCL  A 373 ( 3.8A)
 0.60A 6exiC-3eniA:
undetectable		 6exiC-3eniA:
13.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eoj BACTERIOCHLOROPHYLL
A PROTEIN

(Prosthecochloris
aestuarii) 		PF02327
(BChl_A) 		3 LEU A 295
GLY A 299
PHE A 307
 None
None
BCL  A 373 ( 3.6A)
 0.60A 6exiC-3eojA:
undetectable		 6exiC-3eojA:
12.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fdg DIPEPTIDASE AC.
METALLO PEPTIDASE.
MEROPS FAMILY M19

(Rhodobacter
sphaeroides) 		PF01244
(Peptidase_M19) 		3 LEU A  16
GLY A 307
PHE A 176
 None
 0.55A 6exiC-3fdgA:
undetectable		 6exiC-3fdgA:
12.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fw8 RETICULINE OXIDASE

(Eschscholzia
californica) 		PF01565
(FAD_binding_4)
PF08031
(BBE) 		3 LEU A 109
GLY A 226
PHE A 490
 None
FAD  A   1 (-3.9A)
None
 0.54A 6exiC-3fw8A:
undetectable		 6exiC-3fw8A:
9.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3g1u ADENOSYLHOMOCYSTEINA
SE

(Leishmania
major) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		3 LEU A 343
GLY A 351
PHE A 361
 NAD  A 439 ( 4.0A)
ADN  A 438 ( 3.8A)
None
 0.65A 6exiC-3g1uA:
54.1		 6exiC-3g1uA:
71.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g2f BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-2

(Homo sapiens) 		PF00069
(Pkinase) 		3 LEU A 492
GLY A 410
PHE A 462
 CAS  A 496 ( 4.4A)
None
None
 0.63A 6exiC-3g2fA:
undetectable		 6exiC-3g2fA:
12.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g7u CYTOSINE-SPECIFIC
METHYLTRANSFERASE

(Escherichia
coli) 		PF00145
(DNA_methylase) 		3 LEU A 361
GLY A  72
PHE A 101
 None
 0.52A 6exiC-3g7uA:
3.1		 6exiC-3g7uA:
14.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3glq ADENOSYLHOMOCYSTEINA
SE

(Burkholderia
pseudomallei) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		3 LEU A 385
GLY A 393
PHE A 403
 NAD  A 601 ( 4.1A)
RAB  A 602 ( 3.8A)
None
 0.56A 6exiC-3glqA:
60.3		 6exiC-3glqA:
61.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h9u ADENOSYLHOMOCYSTEINA
SE

(Trypanosoma
brucei) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		3 LEU A 343
GLY A 351
PHE A 361
 NAD  A 438 (-4.0A)
ADN  A 439 (-3.5A)
None
 0.34A 6exiC-3h9uA:
56.4		 6exiC-3h9uA:
13.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hbj FLAVONOID
3-O-GLUCOSYLTRANSFER
ASE

(Medicago
truncatula) 		PF00201
(UDPGT) 		3 LEU A 379
GLY A 148
PHE A 126
 None
 0.55A 6exiC-3hbjA:
5.4		 6exiC-3hbjA:
10.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i2m ORF59

(Human
gammaherpesvirus
8) 		PF04929
(Herpes_DNAp_acc) 		3 LEU X  16
GLY X 100
PHE X  92
 None
 0.62A 6exiC-3i2mX:
undetectable		 6exiC-3i2mX:
15.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iac GLUCURONATE
ISOMERASE

(Salmonella
enterica) 		PF02614
(UxaC) 		3 LEU A 396
GLY A 382
PHE A  32
 None
 0.52A 6exiC-3iacA:
undetectable		 6exiC-3iacA:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ied HEAT SHOCK PROTEIN

(Plasmodium
falciparum) 		PF00183
(HSP90)
PF13589
(HATPase_c_3) 		3 LEU A 212
GLY A 217
PHE A 252
 None
 0.62A 6exiC-3iedA:
undetectable		 6exiC-3iedA:
16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j0h PHIKZ029

(Pseudomonas
virus phiKZ) 		no annotation 3 LEU A 157
GLY A 364
PHE A 344
 None
 0.59A 6exiC-3j0hA:
undetectable		 6exiC-3j0hA:
14.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jcl SPIKE GLYCOPROTEIN

(Murine
coronavirus) 		PF01601
(Corona_S2)
PF09408
(Spike_rec_bind)
PF16451
(Spike_NTD) 		3 LEU A 822
GLY A 926
PHE A 877
 None
 0.67A 6exiC-3jclA:
undetectable		 6exiC-3jclA:
5.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l4c DEDICATOR OF
CYTOKINESIS PROTEIN
1

(Homo sapiens) 		PF14429
(DOCK-C2) 		3 LEU A 432
GLY A 435
PHE A 529
 None
 0.56A 6exiC-3l4cA:
undetectable		 6exiC-3l4cA:
17.48