SIMILAR PATTERNS OF AMINO ACIDS FOR 6EXI_B_ADNB503_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hs7 SYNTAXIN VAM3

(Saccharomyces
cerevisiae) 		PF14523
(Syntaxin_2) 		3 LEU A  68
GLN A  40
LYS A  50
 None
 0.89A 6exiA-1hs7A:
undetectable		 6exiA-1hs7A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kfw CHITINASE B

(Arthrobacter
sp. TAD20) 		PF00704
(Glyco_hydro_18) 		3 LEU A 288
GLN A 396
LYS A 309
 None
 0.67A 6exiA-1kfwA:
undetectable		 6exiA-1kfwA:
12.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kyq SIROHEME
BIOSYNTHESIS PROTEIN
MET8

(Saccharomyces
cerevisiae) 		PF13241
(NAD_binding_7)
PF14823
(Sirohm_synth_C)
PF14824
(Sirohm_synth_M) 		3 LEU A 163
GLN A   6
LYS A  31
 None
 0.90A 6exiA-1kyqA:
4.0		 6exiA-1kyqA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pdz ENOLASE

(Homarus
gammarus) 		PF00113
(Enolase_C)
PF03952
(Enolase_N) 		3 LEU A  81
GLN A  85
LYS A  95
 None
 0.88A 6exiA-1pdzA:
undetectable		 6exiA-1pdzA:
12.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rf5 5-ENOLPYRUVYLSHIKIMA
TE-3-PHOSPHATE
SYNTHASE

(Streptococcus
pneumoniae) 		PF00275
(EPSP_synthase) 		3 LEU A 207
GLN A 201
LYS A 170
 None
 0.91A 6exiA-1rf5A:
undetectable		 6exiA-1rf5A:
13.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sig RNA POLYMERASE
PRIMARY SIGMA FACTOR

(Escherichia
coli) 		PF04542
(Sigma70_r2)
PF04546
(Sigma70_ner) 		3 LEU A 190
GLN A 187
LYS A 376
 None
 0.97A 6exiA-1sigA:
undetectable		 6exiA-1sigA:
13.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1stz HEAT-INDUCIBLE
TRANSCRIPTION
REPRESSOR HRCA
HOMOLOG

(Thermotoga
maritima) 		PF01628
(HrcA) 		3 LEU A  15
GLN A  19
LYS A  82
 None
 0.77A 6exiA-1stzA:
undetectable		 6exiA-1stzA:
13.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u2c DYSTROGLYCAN

(Mus musculus) 		no annotation 3 LEU A 220
GLN A 213
LYS A 203
 None
 0.86A 6exiA-1u2cA:
undetectable		 6exiA-1u2cA:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v8b ADENOSYLHOMOCYSTEINA
SE

(Plasmodium
falciparum) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		3 LEU A 456
GLN A 460
LYS A 473
 None
 0.43A 6exiA-1v8bA:
59.1		 6exiA-1v8bA:
11.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wp9 ATP-DEPENDENT RNA
HELICASE, PUTATIVE

(Pyrococcus
furiosus) 		PF00270
(DEAD)
PF00271
(Helicase_C) 		3 LEU A 288
GLN A 292
LYS A 303
 None
 0.98A 6exiA-1wp9A:
2.5		 6exiA-1wp9A:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wve 4-CRESOL
DEHYDROGENASE
[HYDROXYLATING]
FLAVOPROTEIN SUBUNIT

(Pseudomonas
putida) 		PF01565
(FAD_binding_4)
PF02913
(FAD-oxidase_C) 		3 LEU A  35
GLN A  40
LYS A 112
 None
 0.75A 6exiA-1wveA:
undetectable		 6exiA-1wveA:
9.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z26 ARGONAUTE

(Pyrococcus
furiosus) 		PF02171
(Piwi)
PF12212
(PAZ_siRNAbind) 		3 LEU A 530
GLN A 503
LYS A 513
 None
 0.75A 6exiA-1z26A:
2.1		 6exiA-1z26A:
8.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zip ADENYLATE KINASE

(Geobacillus
stearothermophilus) 		PF00406
(ADK)
PF05191
(ADK_lid) 		3 LEU A 120
GLN A 117
LYS A  13
 None
None
AP5  A 218 (-3.0A)
 0.90A 6exiA-1zipA:
undetectable		 6exiA-1zipA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2abq FRUCTOSE 1-PHOSPHATE
KINASE

(Bacillus
halodurans) 		PF00294
(PfkB) 		3 LEU A  56
GLN A 119
LYS A   1
 None
PO4  A 309 (-4.0A)
None
 1.00A 6exiA-2abqA:
5.0		 6exiA-2abqA:
13.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cjw GTP-BINDING PROTEIN
GEM

(Homo sapiens) 		PF00071
(Ras) 		3 LEU A 171
GLN A 174
LYS A  88
 None
None
GDP  A 999 (-2.7A)
 0.84A 6exiA-2cjwA:
2.3		 6exiA-2cjwA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2efj 3,7-DIMETHYLXANTHINE
METHYLTRANSFERASE

(Coffea
canephora) 		PF03492
(Methyltransf_7) 		3 LEU A  43
GLN A  40
LYS A  92
 None
 0.96A 6exiA-2efjA:
undetectable		 6exiA-2efjA:
11.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f4w UBIQUITIN-CONJUGATIN
G ENZYME E2, J2

(Homo sapiens) 		PF00179
(UQ_con) 		3 LEU A 142
GLN A 145
LYS A  88
 None
 0.88A 6exiA-2f4wA:
undetectable		 6exiA-2f4wA:
17.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ffu POLYPEPTIDE
N-ACETYLGALACTOSAMIN
YLTRANSFERASE 2

(Homo sapiens) 		PF00535
(Glycos_transf_2)
PF00652
(Ricin_B_lectin) 		3 LEU A 415
GLN A 412
LYS A 393
 None
 0.95A 6exiA-2ffuA:
2.3		 6exiA-2ffuA:
9.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hp3 IDS-EPIMERASE

(Agrobacterium
tumefaciens) 		PF03972
(MmgE_PrpD) 		3 LEU A  50
GLN A  47
LYS A  63
 None
None
EDO  A1016 ( 4.7A)
 0.94A 6exiA-2hp3A:
undetectable		 6exiA-2hp3A:
11.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jis CYSTEINE SULFINIC
ACID DECARBOXYLASE

(Homo sapiens) 		PF00282
(Pyridoxal_deC) 		3 LEU A 377
GLN A 372
LYS A 134
 None
 0.92A 6exiA-2jisA:
undetectable		 6exiA-2jisA:
9.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kjg ARCHAEAL PROTEIN
SSO6904

(Sulfolobus
solfataricus) 		no annotation 3 LEU A  23
GLN A  26
LYS A  58
 None
 0.90A 6exiA-2kjgA:
undetectable		 6exiA-2kjgA:
24.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2m09 SPLICING FACTOR 1

(Homo sapiens) 		PF16275
(SF1-HH) 		3 LEU A 112
GLN A  57
LYS A 104
 None
 0.99A 6exiA-2m09A:
undetectable		 6exiA-2m09A:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mtd DECORIN BINDING
PROTEIN A

(Borreliella
garinii) 		PF02352
(Decorin_bind) 		3 LEU A  76
GLN A 168
LYS A 178
 None
 0.92A 6exiA-2mtdA:
undetectable		 6exiA-2mtdA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nzj GTP-BINDING PROTEIN
REM 1

(Homo sapiens) 		PF00071
(Ras) 		3 LEU A 175
GLN A 178
LYS A  93
 None
None
GDP  A1001 (-3.0A)
 0.94A 6exiA-2nzjA:
3.9		 6exiA-2nzjA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2po4 VIRION RNA
POLYMERASE

(Escherichia
virus N4) 		no annotation 3 LEU A 649
GLN A 724
LYS A 740
 None
 0.96A 6exiA-2po4A:
undetectable		 6exiA-2po4A:
6.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2poe CYCLOPHILIN-LIKE
PROTEIN, PUTATIVE

(Cryptosporidium
parvum) 		PF00160
(Pro_isomerase) 		3 LEU A 131
GLN A 130
LYS A 108
 None
None
FMT  A 203 ( 4.8A)
 0.93A 6exiA-2poeA:
undetectable		 6exiA-2poeA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pp3 L-TALARATE/GALACTARA
TE DEHYDRATASE

(Salmonella
enterica) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		3 LEU A 291
GLN A 288
LYS A 320
 None
 0.99A 6exiA-2pp3A:
undetectable		 6exiA-2pp3A:
11.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qgm SUCCINOGLYCAN
BIOSYNTHESIS PROTEIN

(Bacillus cereus) 		PF05139
(Erythro_esteras) 		3 LEU A 281
GLN A 284
LYS A 227
 None
 0.84A 6exiA-2qgmA:
undetectable		 6exiA-2qgmA:
13.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qq4 IRON-SULFUR CLUSTER
BIOSYNTHESIS PROTEIN
ISCU

(Thermus
thermophilus) 		PF01592
(NifU_N) 		3 LEU A  25
GLN A  27
LYS A  79
 None
 0.96A 6exiA-2qq4A:
undetectable		 6exiA-2qq4A:
25.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wa5 FILAMIN-B

(Homo sapiens) 		PF00307
(CH) 		3 LEU A 182
GLN A 204
LYS A 241
 None
 0.81A 6exiA-2wa5A:
undetectable		 6exiA-2wa5A:
14.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wvf PUTATIVE
NICKEL-RESPONSIVE
REGULATOR

(Helicobacter
pylori) 		PF01402
(RHH_1)
PF08753
(NikR_C) 		3 LEU A 138
GLN A 124
LYS A  64
 None
 0.92A 6exiA-2wvfA:
undetectable		 6exiA-2wvfA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xn1 ALPHA-GALACTOSIDASE

(Lactobacillus
acidophilus) 		PF02065
(Melibiase)
PF16874
(Glyco_hydro_36C)
PF16875
(Glyco_hydro_36N) 		3 LEU A  50
GLN A  49
LYS A 192
 None
 0.75A 6exiA-2xn1A:
undetectable		 6exiA-2xn1A:
8.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xwu IMPORTIN13

(Homo sapiens) 		PF03810
(IBN_N)
PF08389
(Xpo1) 		3 LEU B 164
GLN B 160
LYS B 224
 None
 0.88A 6exiA-2xwuB:
undetectable		 6exiA-2xwuB:
6.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ywm GLUTAREDOXIN-LIKE
PROTEIN

(Aquifex
aeolicus) 		PF13192
(Thioredoxin_3) 		3 LEU A 181
GLN A 184
LYS A 171
 None
 0.97A 6exiA-2ywmA:
undetectable		 6exiA-2ywmA:
14.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yzu THIOREDOXIN

(Thermus
thermophilus) 		PF00085
(Thioredoxin) 		3 LEU A  89
GLN A  93
LYS A 104
 None
 1.00A 6exiA-2yzuA:
undetectable		 6exiA-2yzuA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bd9 HEPARAN SULFATE
GLUCOSAMINE
3-O-SULFOTRANSFERASE
5

(Homo sapiens) 		PF00685
(Sulfotransfer_1) 		3 LEU A 263
GLN A 281
LYS A 271
 None
 0.88A 6exiA-3bd9A:
undetectable		 6exiA-3bd9A:
15.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ce6 ADENOSYLHOMOCYSTEINA
SE

(Mycobacterium
tuberculosis) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		3 LEU A 472
GLN A 476
LYS A 489
 None
 0.39A 6exiA-3ce6A:
59.6		 6exiA-3ce6A:
60.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3clk TRANSCRIPTION
REGULATOR

(Lactobacillus
plantarum) 		PF13377
(Peripla_BP_3) 		3 LEU A 239
GLN A 180
LYS A 217
 None
 0.75A 6exiA-3clkA:
2.4		 6exiA-3clkA:
15.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3etv PROTEIN TRANSPORT
PROTEIN TIP20,
PROTEIN TRANSPORT
PROTEIN DSL1 CHIMERA

(Saccharomyces
cerevisiae) 		PF11988
(Dsl1_N) 		3 LEU A 129
GLN A 203
LYS A 137
 None
 0.90A 6exiA-3etvA:
undetectable		 6exiA-3etvA:
10.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f0n MEVALONATE
PYROPHOSPHATE
DECARBOXYLASE

(Mus musculus) 		PF00288
(GHMP_kinases_N) 		3 LEU A 389
GLN A 397
LYS A  49
 None
 0.89A 6exiA-3f0nA:
undetectable		 6exiA-3f0nA:
12.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fb4 ADENYLATE KINASE

(Jeotgalibacillus
marinus) 		PF00406
(ADK)
PF05191
(ADK_lid) 		3 LEU A 120
GLN A 117
LYS A  13
 None
None
AP5  A   0 (-3.1A)
 0.70A 6exiA-3fb4A:
undetectable		 6exiA-3fb4A:
18.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3glq ADENOSYLHOMOCYSTEINA
SE

(Burkholderia
pseudomallei) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		3 LEU A 450
GLN A 454
LYS A 467
 None
 0.31A 6exiA-3glqA:
60.2		 6exiA-3glqA:
61.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3gvp ADENOSYLHOMOCYSTEINA
SE 3

(Homo sapiens) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		3 LEU A 588
GLN A 592
LYS A 605
 None
 0.35A 6exiA-3gvpA:
43.4		 6exiA-3gvpA:
51.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h9u ADENOSYLHOMOCYSTEINA
SE

(Trypanosoma
brucei) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		3 LEU A 414
GLN A 418
LYS A 431
 None
 0.43A 6exiA-3h9uA:
56.3		 6exiA-3h9uA:
13.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hrd NICOTINATE
DEHYDROGENASE LARGE
MOLYBDOPTERIN
SUBUNIT

(Eubacterium
barkeri) 		PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2) 		3 LEU A 245
GLN A 248
LYS A  77
 None
MG  A 426 (-4.2A)
None
 0.91A 6exiA-3hrdA:
undetectable		 6exiA-3hrdA:
12.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i4r NUCLEAR PORE COMPLEX
PROTEIN NUP133

(Homo sapiens) 		PF03177
(Nucleoporin_C) 		3 LEU B1119
GLN B1155
LYS B1097
 None
 0.90A 6exiA-3i4rB:
undetectable		 6exiA-3i4rB:
9.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ih5 ELECTRON TRANSFER
FLAVOPROTEIN
ALPHA-SUBUNIT

(Bacteroides
thetaiotaomicron) 		PF01012
(ETF) 		3 LEU A 139
GLN A 163
LYS A 134
 None
 0.81A 6exiA-3ih5A:
3.3		 6exiA-3ih5A:
16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mpp BOTULINUM NEUROTOXIN
TYPE G

(Clostridium
botulinum) 		PF07951
(Toxin_R_bind_C)
PF07953
(Toxin_R_bind_N) 		3 LEU G1270
GLN G1267
LYS G1219
 None
 0.96A 6exiA-3mppG:
undetectable		 6exiA-3mppG:
10.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n58 ADENOSYLHOMOCYSTEINA
SE

(Brucella
abortus) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		3 LEU A 443
GLN A 447
LYS A 460
 None
 0.20A 6exiA-3n58A:
61.1		 6exiA-3n58A:
14.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o0y LIPOPROTEIN

(Colwellia
psychrerythraea) 		PF05960
(DUF885) 		3 LEU A 300
GLN A 304
LYS A 562
 None
 0.88A 6exiA-3o0yA:
undetectable		 6exiA-3o0yA:
11.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3one ADENOSYLHOMOCYSTEINA
SE

(Lupinus luteus) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		3 LEU A 462
GLN A 466
LYS A 479
 None
 0.26A 6exiA-3oneA:
56.4		 6exiA-3oneA:
64.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3opy 6-PHOSPHOFRUCTO-1-KI
NASE ALPHA-SUBUNIT
6-PHOSPHOFRUCTO-1-KI
NASE BETA-SUBUNIT

(Komagataella
pastoris;
Komagataella
pastoris) 		PF00365
(PFK)
PF00365
(PFK) 		3 LEU A  84
GLN A  85
LYS B 573
 None
 0.96A 6exiA-3opyA:
2.5		 6exiA-3opyA:
6.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s9f TRYPAREDOXIN

(Leishmania
major) 		PF13905
(Thioredoxin_8) 		3 LEU A 131
GLN A  49
LYS A  61
 None
 0.60A 6exiA-3s9fA:
undetectable		 6exiA-3s9fA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ss7 D-SERINE DEHYDRATASE

(Escherichia
coli) 		PF00291
(PALP) 		3 LEU X 320
GLN X 323
LYS X   6
 None
 0.92A 6exiA-3ss7X:
3.4		 6exiA-3ss7X:
11.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3taw HYPOTHETICAL
GLYCOSIDE HYDROLASE

(Parabacteroides
distasonis) 		PF04041
(Glyco_hydro_130) 		3 LEU A 274
GLN A 273
LYS A 207
 None
None
UNL  A 387 (-2.7A)
 0.80A 6exiA-3tawA:
undetectable		 6exiA-3tawA:
13.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3trc PHOSPHOENOLPYRUVATE-
PROTEIN
PHOSPHOTRANSFERASE

(Coxiella
burnetii) 		PF01590
(GAF) 		3 LEU A 104
GLN A  64
LYS A  99
 None
 0.91A 6exiA-3trcA:
undetectable		 6exiA-3trcA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u95 GLYCOSIDE HYDROLASE,
FAMILY 4

(Thermotoga
neapolitana) 		PF02056
(Glyco_hydro_4)
PF11975
(Glyco_hydro_4C) 		3 LEU A 341
GLN A  23
LYS A 357
 None
 0.82A 6exiA-3u95A:
4.4		 6exiA-3u95A:
12.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ars HISTIDINE ACID
PHOSPHATASE

(Hafnia alvei) 		PF00328
(His_Phos_2) 		3 LEU A 370
GLN A 371
LYS A  76
 None
 0.92A 6exiA-4arsA:
undetectable		 6exiA-4arsA:
12.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b7l FILAMIN-B

(Homo sapiens) 		PF00307
(CH)
PF00630
(Filamin) 		3 LEU A 107
GLN A  41
LYS A  13
 None
 0.99A 6exiA-4b7lA:
undetectable		 6exiA-4b7lA:
13.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b8c GLUCOSE-REPRESSIBLE
ALCOHOL
DEHYDROGENASE
TRANSCRIPTIONAL
EFFECTOR

(Saccharomyces
cerevisiae) 		PF03372
(Exo_endo_phos)
PF13855
(LRR_8) 		3 LEU D 540
GLN D 543
LYS D 557
 None
 0.92A 6exiA-4b8cD:
undetectable		 6exiA-4b8cD:
8.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c0r PUTATIVE AMINO ACID
BINDING PROTEIN

(Streptococcus
mutans) 		PF00497
(SBP_bac_3) 		3 LEU A 138
GLN A 125
LYS A 160
 None
None
GDS  A 500 (-2.7A)
 1.00A 6exiA-4c0rA:
undetectable		 6exiA-4c0rA:
15.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d10 COP9 SIGNALOSOME
COMPLEX SUBUNIT 3

(Homo sapiens) 		PF01399
(PCI) 		3 LEU C  77
GLN C  80
LYS C  65
 None
 0.94A 6exiA-4d10C:
undetectable		 6exiA-4d10C:
11.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eba MRNA
3'-END-PROCESSING
PROTEIN RNA14
RNA15

(Kluyveromyces
lactis;
Kluyveromyces
lactis) 		PF05843
(Suf)
PF14327
(CSTF2_hinge) 		3 LEU G 171
GLN G 170
LYS A 624
 None
 0.85A 6exiA-4ebaG:
undetectable		 6exiA-4ebaG:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hgv FUMARATE HYDRATASE
CLASS II

(Sinorhizobium
meliloti) 		PF00206
(Lyase_1)
PF10415
(FumaraseC_C) 		3 LEU A  40
GLN A  37
LYS A  49
 None
 0.82A 6exiA-4hgvA:
undetectable		 6exiA-4hgvA:
10.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jeu SYNTAXIN-BINDING
PROTEIN 1

(Rattus
norvegicus) 		PF00995
(Sec1) 		3 LEU A 547
GLN A 250
LYS A 577
 None
 0.95A 6exiA-4jeuA:
3.5		 6exiA-4jeuA:
10.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kxr ESPG5

(Mycobacterium
tuberculosis) 		PF14011
(ESX-1_EspG) 		3 LEU C 268
GLN C 256
LYS C 245
 None
 0.98A 6exiA-4kxrC:
undetectable		 6exiA-4kxrC:
15.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4lvc S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(SAHASE)

(Bradyrhizobium
elkanii) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		3 LEU A 450
GLN A 454
LYS A 467
 None
 0.16A 6exiA-4lvcA:
68.4		 6exiA-4lvcA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nnb OBCA, OXALATE
BIOSYNTHETIC
COMPONENT A

(Burkholderia
glumae) 		PF05853
(BKACE) 		3 LEU A 512
GLN A 516
LYS A 443
 None
 0.94A 6exiA-4nnbA:
undetectable		 6exiA-4nnbA:
9.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r61 GP41-BASED CONSTRUCT
COVNHR3-ABC

(Human
immunodeficiency
virus 1) 		no annotation 3 LEU A  85
GLN A  23
LYS A  33
 None
 0.88A 6exiA-4r61A:
undetectable		 6exiA-4r61A:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tz5 PUTATIVE SECRETED
PROTEIN

(Streptomyces
sp. SirexAA-E) 		no annotation 3 LEU A 302
GLN A 306
LYS A 377
 None
 0.82A 6exiA-4tz5A:
undetectable		 6exiA-4tz5A:
10.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wbd BSHC

(Bacillus
subtilis) 		PF10079
(BshC) 		3 LEU A   6
GLN A 399
LYS A 538
 None
 0.86A 6exiA-4wbdA:
undetectable		 6exiA-4wbdA:
11.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a7v PUTATIVE GLYCOSIDASE
PH117-RELATED

(Bacteroides
thetaiotaomicron) 		PF04041
(Glyco_hydro_130) 		3 LEU B 266
GLN B 265
LYS B 199
 None
None
MAN  B1485 ( 2.8A)
 0.81A 6exiA-5a7vB:
undetectable		 6exiA-5a7vB:
12.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aor DOSAGE COMPENSATION
REGULATOR

(Drosophila
melanogaster) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF04408
(HA2)
PF07717
(OB_NTP_bind) 		3 LEU A 907
GLN A 911
LYS A1064
 None
None
U  C   4 ( 4.5A)
 0.77A 6exiA-5aorA:
3.0		 6exiA-5aorA:
5.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dm5 PUTATIVE ACYL-COA
THIOESTER HYDROLASE

(Yersinia pestis) 		PF03061
(4HBT) 		3 LEU A  21
GLN A  44
LYS A  54
 None
 0.85A 6exiA-5dm5A:
undetectable		 6exiA-5dm5A:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eg6 RECOMBINING BINDING
PROTEIN SUPPRESSOR
OF HAIRLESS

(Mus musculus) 		PF09270
(BTD)
PF09271
(LAG1-DNAbind) 		3 LEU C 316
GLN C 333
LYS C 275
 None
 0.96A 6exiA-5eg6C:
undetectable		 6exiA-5eg6C:
10.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ej1 PUTATIVE CELLULOSE
SYNTHASE

(Rhodobacter
sphaeroides) 		PF00535
(Glycos_transf_2)
PF03552
(Cellulose_synt)
PF07238
(PilZ) 		3 LEU A 402
GLN A 406
LYS A 394
 None
 0.94A 6exiA-5ej1A:
2.7		 6exiA-5ej1A:
8.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5flz SPINDLE POLE BODY
COMPONENT SPC97

(Saccharomyces
cerevisiae) 		PF04130
(Spc97_Spc98) 		3 LEU A 189
GLN A 115
LYS A 125
 None
 0.99A 6exiA-5flzA:
undetectable		 6exiA-5flzA:
7.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jem CREB-BINDING PROTEIN

(Homo sapiens) 		PF09030
(Creb_binding)
PF11707
(Npa1) 		3 LEU C2087
GLN C2084
LYS C2065
 None
 0.99A 6exiA-5jemC:
undetectable		 6exiA-5jemC:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k1g 1-CYS PEROXIREDOXIN

(Vibrio
vulnificus) 		PF08534
(Redoxin) 		3 LEU A  95
GLN A  15
LYS A  33
 None
 0.86A 6exiA-5k1gA:
undetectable		 6exiA-5k1gA:
24.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k35 ANKYRIN-REPEAT
PROTEIN B

(Legionella
pneumophila) 		PF12937
(F-box-like) 		3 LEU A  72
GLN A 108
LYS A  80
 None
 0.92A 6exiA-5k35A:
undetectable		 6exiA-5k35A:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mdx CHLOROPHYLL A-B
BINDING PROTEIN
CP26, CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF00504
(Chloroa_b-bind) 		3 LEU S 220
GLN S 217
LYS S  61
 None
 0.94A 6exiA-5mdxS:
undetectable		 6exiA-5mdxS:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mpd 26S PROTEASOME
REGULATORY SUBUNIT
RPN2

(Saccharomyces
cerevisiae) 		PF01851
(PC_rep)
PF13646
(HEAT_2) 		3 LEU N 253
GLN N 256
LYS N 244
 None
 0.99A 6exiA-5mpdN:
undetectable		 6exiA-5mpdN:
6.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mpd 26S PROTEASOME
REGULATORY SUBUNIT
RPN9

(Saccharomyces
cerevisiae) 		PF01399
(PCI) 		3 LEU O 336
GLN O 354
LYS O 290
 None
 0.88A 6exiA-5mpdO:
undetectable		 6exiA-5mpdO:
12.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nnn CTATC

(Chaetomium
thermophilum) 		PF00185
(OTCace)
PF02729
(OTCace_N) 		3 LEU A1968
GLN A1971
LYS A1951
 None
 0.98A 6exiA-5nnnA:
8.9		 6exiA-5nnnA:
13.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o9g CHROMO
DOMAIN-CONTAINING
PROTEIN 1

(Saccharomyces
cerevisiae) 		no annotation 3 LEU W 376
GLN W 380
LYS W 446
 ADP  W1501 (-4.1A)
None
None
 0.96A 6exiA-5o9gW:
2.8		 6exiA-5o9gW:
4.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ot4 INTERAPTIN

(Legionella
pneumophila) 		no annotation 3 LEU A 711
GLN A 708
LYS A 807
 None
 0.90A 6exiA-5ot4A:
undetectable		 6exiA-5ot4A:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5utu ADENOSYLHOMOCYSTEINA
SE

(Cryptosporidium
parvum) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		3 LEU A 472
GLN A 476
LYS A 489
 None
 0.26A 6exiA-5utuA:
53.7		 6exiA-5utuA:
9.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v8f ORIGIN RECOGNITION
COMPLEX SUBUNIT 3

(Saccharomyces
cerevisiae) 		no annotation 3 LEU C  60
GLN C  63
LYS C 291
 None
 0.87A 6exiA-5v8fC:
undetectable		 6exiA-5v8fC:
8.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v96 S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE

(Naegleria
fowleri) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		3 LEU A 449
GLN A 453
LYS A 466
 None
 0.23A 6exiA-5v96A:
61.0		 6exiA-5v96A:
13.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vm9 PROTEIN ARGONAUTE-3

(Homo sapiens) 		no annotation 3 LEU A 564
GLN A 546
LYS A 555
 A  B   2 ( 4.0A)
A  B   1 ( 3.0A)
None
 0.71A 6exiA-5vm9A:
undetectable		 6exiA-5vm9A:
7.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w4b ADENOSYLHOMOCYSTEINA
SE

(Homo sapiens) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		3 LEU A 409
GLN A 413
LYS A 426
 None
 0.22A 6exiA-5w4bA:
48.4		 6exiA-5w4bA:
12.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w68 PUTATIVE TYPE II
SECRETION PROTEIN

(Escherichia
coli) 		no annotation 3 LEU A 483
GLN A 362
LYS A 293
 None
 0.99A 6exiA-5w68A:
undetectable		 6exiA-5w68A:
11.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wfi -

(-) 		no annotation 3 LEU A1637
GLN A1663
LYS A1610
 None
GOL  A2002 (-3.8A)
None
 0.95A 6exiA-5wfiA:
undetectable		 6exiA-5wfiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yi0 ZINC TRANSPORT
TRANSCRIPTIONAL
REGULATOR

(Lactococcus
lactis) 		no annotation 3 LEU B  36
GLN B  40
LYS B 100
 None
 0.74A 6exiA-5yi0B:
undetectable		 6exiA-5yi0B:
26.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z06 BDI_3064 PROTEIN

(Parabacteroides
distasonis) 		no annotation 3 LEU A 369
GLN A 366
LYS A 438
 None
 0.96A 6exiA-5z06A:
undetectable		 6exiA-5z06A:
21.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6aph ADENOSYLHOMOCYSTEINA
SE

(Elizabethkingia
anophelis) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		3 LEU A 414
GLN A 418
LYS A 431
 None
 0.22A 6exiA-6aphA:
56.9		 6exiA-6aphA:
69.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bc1 RHO GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 28

(Homo sapiens) 		no annotation 3 LEU C1055
GLN C1052
LYS C1084
 None
 0.99A 6exiA-6bc1C:
undetectable		 6exiA-6bc1C:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f3m -

(-) 		no annotation 3 LEU B 446
GLN B 450
LYS B 463
 None
 0.30A 6exiA-6f3mB:
52.3		 6exiA-6f3mB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gbn -

(-) 		no annotation 3 LEU A 412
GLN A 416
LYS A 429
 None
 0.19A 6exiA-6gbnA:
57.3		 6exiA-6gbnA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gw5 -

(-) 		no annotation 3 LEU A  94
GLN A 160
LYS A 150
 None
 0.99A 6exiA-6gw5A:
undetectable		 6exiA-6gw5A:
undetectable