SIMILAR PATTERNS OF AMINO ACIDS FOR 6EXI_A_ADNA502_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b6r PROTEIN
(N5-CARBOXYAMINOIMID
AZOLE RIBONUCLEOTIDE
SYNTHETASE)

(Escherichia
coli) 		PF02222
(ATP-grasp) 		3 LEU A 335
ASN A 252
LEU A 328
 None
 0.69A 6exiA-1b6rA:
1.4		 6exiA-1b6rA:
12.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b7e PROTEIN (TRANSPOSASE
INHIBITOR PROTEIN
FROM TN5)

(Escherichia
coli) 		PF01609
(DDE_Tnp_1)
PF02281
(Dimer_Tnp_Tn5) 		3 LEU A 301
ASN A 276
LEU A 201
 None
 0.62A 6exiA-1b7eA:
undetectable		 6exiA-1b7eA:
11.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b9l PROTEIN (EPIMERASE)

(Escherichia
coli) 		PF02152
(FolB) 		3 LEU A  13
ASN A  70
LEU A  79
 None
 0.57A 6exiA-1b9lA:
undetectable		 6exiA-1b9lA:
25.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bhg BETA-GLUCURONIDASE

(Homo sapiens) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N) 		3 LEU A 565
ASN A 349
LEU A 622
 None
 0.60A 6exiA-1bhgA:
0.7		 6exiA-1bhgA:
11.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bhg BETA-GLUCURONIDASE

(Homo sapiens) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N) 		3 LEU A 573
ASN A 349
LEU A 622
 None
 0.65A 6exiA-1bhgA:
0.7		 6exiA-1bhgA:
11.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bqg D-GLUCARATE
DEHYDRATASE

(Pseudomonas
putida) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		3 LEU A 130
ASN A  91
LEU A  78
 None
 0.70A 6exiA-1bqgA:
undetectable		 6exiA-1bqgA:
11.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cjy PROTEIN (CYTOSOLIC
PHOSPHOLIPASE A2)

(Homo sapiens) 		PF00168
(C2)
PF01735
(PLA2_B) 		3 LEU A 570
ASN A 704
LEU A 212
 None
 0.60A 6exiA-1cjyA:
undetectable		 6exiA-1cjyA:
7.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cqk CH3 DOMAIN OF MAK33
ANTIBODY

(Mus musculus) 		PF07654
(C1-set) 		3 LEU A  23
ASN A  82
LEU A  26
 None
 0.68A 6exiA-1cqkA:
undetectable		 6exiA-1cqkA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dce PROTEIN (RAB
GERANYLGERANYLTRANSF
ERASE ALPHA SUBUNIT)

(Rattus
norvegicus) 		PF01239
(PPTA)
PF07711
(RabGGT_insert) 		3 LEU A 462
ASN A 473
LEU A 478
 None
 0.70A 6exiA-1dceA:
undetectable		 6exiA-1dceA:
10.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f59 IMPORTIN BETA-1

(Homo sapiens) 		PF03810
(IBN_N)
PF13513
(HEAT_EZ) 		3 LEU A  65
ASN A  93
LEU A  44
 None
 0.70A 6exiA-1f59A:
undetectable		 6exiA-1f59A:
12.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f8f BENZYL ALCOHOL
DEHYDROGENASE

(Acinetobacter
calcoaceticus) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		3 LEU A   4
ASN A 124
LEU A 150
 None
 0.68A 6exiA-1f8fA:
9.8		 6exiA-1f8fA:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fhf SEED COAT PEROXIDASE

(Glycine max) 		PF00141
(peroxidase) 		3 LEU A 183
ASN A 219
LEU A 243
 None
 0.70A 6exiA-1fhfA:
undetectable		 6exiA-1fhfA:
12.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fn9 OUTER-CAPSID PROTEIN
SIGMA 3

(Reovirus sp.) 		PF00979
(Reovirus_cap) 		3 LEU A 131
ASN A 139
LEU A 265
 None
 0.68A 6exiA-1fn9A:
undetectable		 6exiA-1fn9A:
13.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fs2 SKP2

(Homo sapiens) 		PF12937
(F-box-like) 		3 LEU A 260
ASN A 301
LEU A 270
 None
 0.68A 6exiA-1fs2A:
undetectable		 6exiA-1fs2A:
15.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fs2 SKP2

(Homo sapiens) 		PF12937
(F-box-like) 		3 LEU A 317
ASN A 274
LEU A 264
 None
 0.43A 6exiA-1fs2A:
undetectable		 6exiA-1fs2A:
15.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gnx BETA-GLUCOSIDASE

(Streptomyces
sp.) 		PF00232
(Glyco_hydro_1) 		3 LEU A 377
ASN A 307
LEU A 367
 None
 0.64A 6exiA-1gnxA:
undetectable		 6exiA-1gnxA:
12.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h4l CELL DIVISION
PROTEIN KINASE 5

(Homo sapiens) 		PF00069
(Pkinase) 		3 LEU A 195
ASN A  62
LEU A 127
 None
 0.66A 6exiA-1h4lA:
undetectable		 6exiA-1h4lA:
11.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hfs STROMELYSIN-1

(Homo sapiens) 		PF00413
(Peptidase_M10) 		3 LEU A 245
ASN A 175
LEU A  97
 None
 0.62A 6exiA-1hfsA:
undetectable		 6exiA-1hfsA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hlg LIPASE, GASTRIC

(Homo sapiens) 		PF00561
(Abhydrolase_1) 		3 LEU A 240
ASN A 250
LEU A 256
 None
 0.61A 6exiA-1hlgA:
5.3		 6exiA-1hlgA:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i5p PESTICIDIAL CRYSTAL
PROTEIN CRY2AA

(Bacillus
thuringiensis) 		PF03944
(Endotoxin_C)
PF03945
(Endotoxin_N)
PF09131
(Endotoxin_mid) 		3 LEU A  62
ASN A 274
LEU A 250
 None
 0.55A 6exiA-1i5pA:
undetectable		 6exiA-1i5pA:
8.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iko EPHRIN-B2

(Mus musculus) 		PF00812
(Ephrin) 		3 LEU P  61
ASN P  39
LEU P 102
 None
NAG  P   1 (-1.8A)
None
 0.45A 6exiA-1ikoP:
undetectable		 6exiA-1ikoP:
15.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iv8 MALTOOLIGOSYL
TREHALOSE SYNTHASE

(Sulfolobus
acidocaldarius) 		PF00128
(Alpha-amylase)
PF09196
(DUF1953) 		3 LEU A 689
ASN A 711
LEU A 664
 None
 0.69A 6exiA-1iv8A:
undetectable		 6exiA-1iv8A:
7.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jch COLICIN E3 IMMUNITY
PROTEIN

(Escherichia
coli) 		PF03513
(Cloacin_immun) 		3 LEU B  58
ASN B  42
LEU B   2
 None
 0.71A 6exiA-1jchB:
undetectable		 6exiA-1jchB:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jjo NEUROSERPIN

(Mus musculus) 		PF00079
(Serpin) 		3 LEU C 131
ASN C 181
LEU C 184
 None
 0.59A 6exiA-1jjoC:
undetectable		 6exiA-1jjoC:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jl5 OUTER PROTEIN YOPM

(Yersinia pestis) 		PF12468
(TTSSLRR) 		3 LEU A1096
ASN A1122
LEU A1126
 None
 0.60A 6exiA-1jl5A:
undetectable		 6exiA-1jl5A:
9.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jl5 OUTER PROTEIN YOPM

(Yersinia pestis) 		PF12468
(TTSSLRR) 		3 LEU A1332
ASN A1303
LEU A1295
 None
 0.62A 6exiA-1jl5A:
undetectable		 6exiA-1jl5A:
9.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jmu PROTEIN MU-1

(Reovirus sp.) 		PF05993
(Reovirus_M2) 		3 LEU B 219
ASN B 202
LEU B 665
 BOG  B 709 ( 4.4A)
None
None
 0.64A 6exiA-1jmuB:
undetectable		 6exiA-1jmuB:
8.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jqo PHOSPHOENOLPYRUVATE
CARBOXYLASE

(Zea mays) 		PF00311
(PEPcase) 		3 LEU A 611
ASN A 808
LEU A 870
 None
 0.64A 6exiA-1jqoA:
undetectable		 6exiA-1jqoA:
6.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jsw L-ASPARTATE
AMMONIA-LYASE

(Escherichia
coli) 		PF00206
(Lyase_1)
PF10415
(FumaraseC_C) 		3 LEU A 211
ASN A 337
LEU A 379
 None
 0.55A 6exiA-1jswA:
undetectable		 6exiA-1jswA:
12.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jtd BETA-LACTAMASE
INHIBITOR PROTEIN II

(Streptomyces
exfoliatus) 		PF13540
(RCC1_2) 		3 LEU B 258
ASN B 246
LEU B 233
 None
 0.68A 6exiA-1jtdB:
undetectable		 6exiA-1jtdB:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kgs DNA BINDING RESPONSE
REGULATOR D

(Thermotoga
maritima) 		PF00072
(Response_reg)
PF00486
(Trans_reg_C) 		3 LEU A  52
ASN A  74
LEU A 117
 None
 0.62A 6exiA-1kgsA:
6.1		 6exiA-1kgsA:
15.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1krq FERRITIN

(Campylobacter
jejuni) 		PF00210
(Ferritin) 		3 LEU A  57
ASN A 118
LEU A   2
 None
 0.64A 6exiA-1krqA:
undetectable		 6exiA-1krqA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mz5 SIALIDASE

(Trypanosoma
rangeli) 		PF13385
(Laminin_G_3)
PF13859
(BNR_3) 		3 LEU A 501
ASN A 605
LEU A 485
 None
 0.70A 6exiA-1mz5A:
undetectable		 6exiA-1mz5A:
8.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nlu SEDOLISIN

(Pseudomonas sp.) 		no annotation 3 LEU A 356
ASN A 368
LEU A 308
 None
 0.69A 6exiA-1nluA:
undetectable		 6exiA-1nluA:
12.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nq4 OXYTETRACYCLINE
POLYKETIDE SYNTHASE
ACYL CARRIER PROTEIN

(Streptomyces
rimosus) 		PF00550
(PP-binding) 		3 LEU A  37
ASN A  46
LEU A  73
 None
 0.65A 6exiA-1nq4A:
undetectable		 6exiA-1nq4A:
26.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1po0 IRON(III) DICITRATE
TRANSPORT PROTEIN
FECA PRECURSOR

(Escherichia
coli) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		3 LEU A 179
ASN A 213
LEU A 124
 None
 0.66A 6exiA-1po0A:
undetectable		 6exiA-1po0A:
8.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q50 GLUCOSE-6-PHOSPHATE
ISOMERASE

(Leishmania
mexicana) 		PF00342
(PGI) 		3 LEU A  51
ASN A 380
LEU A 118
 None
 0.67A 6exiA-1q50A:
undetectable		 6exiA-1q50A:
10.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q5a EP-CADHERIN

(Mus musculus) 		PF00028
(Cadherin) 		3 LEU A 354
ASN A 373
LEU A 379
 None
 0.64A 6exiA-1q5aA:
undetectable		 6exiA-1q5aA:
6.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q5a EP-CADHERIN

(Mus musculus) 		PF00028
(Cadherin) 		3 LEU A 354
ASN A 373
LEU A 428
 None
 0.48A 6exiA-1q5aA:
undetectable		 6exiA-1q5aA:
6.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q5a EP-CADHERIN

(Mus musculus) 		PF00028
(Cadherin) 		3 LEU A 354
ASN A 391
LEU A 428
 None
 0.00A 6exiA-1q5aA:
undetectable		 6exiA-1q5aA:
6.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q8i DNA POLYMERASE II

(Escherichia
coli) 		PF00136
(DNA_pol_B)
PF03104
(DNA_pol_B_exo1) 		3 LEU A  32
ASN A 137
LEU A 140
 None
 0.53A 6exiA-1q8iA:
undetectable		 6exiA-1q8iA:
8.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qo4 PEROXIDASE

(Arabidopsis
thaliana) 		PF00141
(peroxidase) 		3 LEU A 183
ASN A 219
LEU A 243
 None
 0.70A 6exiA-1qo4A:
undetectable		 6exiA-1qo4A:
14.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r20 ULTRASPIRACLE
PROTEIN

(Heliothis
virescens) 		PF00104
(Hormone_recep) 		3 LEU A 208
ASN A 376
LEU A 273
 None
 0.66A 6exiA-1r20A:
undetectable		 6exiA-1r20A:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rjc CAMELID HEAVY CHAIN
ANTIBODY

(Camelus
dromedarius) 		PF07686
(V-set) 		3 LEU A   4
ASN A  32
LEU A  72
 None
 0.56A 6exiA-1rjcA:
undetectable		 6exiA-1rjcA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rpt PROSTATIC ACID
PHOSPHATASE

(Rattus
norvegicus) 		PF00328
(His_Phos_2) 		3 LEU A 312
ASN A 233
LEU A 264
 None
 0.54A 6exiA-1rptA:
undetectable		 6exiA-1rptA:
15.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ryy ALPHA-AMINO ACID
ESTER HYDROLASE

(Acetobacter
pasteurianus) 		PF02129
(Peptidase_S15)
PF08530
(PepX_C) 		3 LEU A 446
ASN A 603
LEU A 547
 None
 0.59A 6exiA-1ryyA:
3.3		 6exiA-1ryyA:
7.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1slm STROMELYSIN-1

(Homo sapiens) 		PF00413
(Peptidase_M10)
PF01471
(PG_binding_1) 		3 LEU A 245
ASN A 175
LEU A  97
 None
 0.68A 6exiA-1slmA:
undetectable		 6exiA-1slmA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sus CAFFEOYL-COA
O-METHYLTRANSFERASE

(Medicago sativa) 		PF01596
(Methyltransf_3) 		3 LEU A  94
ASN A  82
LEU A  75
 None
 0.59A 6exiA-1susA:
3.1		 6exiA-1susA:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1szs 4-AMINOBUTYRATE
AMINOTRANSFERASE

(Escherichia
coli) 		PF00202
(Aminotran_3) 		3 LEU A 276
ASN A  94
LEU A 312
 None
 0.67A 6exiA-1szsA:
undetectable		 6exiA-1szsA:
11.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t3i PROBABLE CYSTEINE
DESULFURASE

(Synechocystis
sp.) 		PF00266
(Aminotran_5) 		3 LEU A 342
ASN A 346
LEU A 321
 None
 0.70A 6exiA-1t3iA:
2.1		 6exiA-1t3iA:
10.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t90 PROBABLE
METHYLMALONATE-SEMIA
LDEHYDE
DEHYDROGENASE

(Bacillus
subtilis) 		PF00171
(Aldedh) 		3 LEU A  72
ASN A 463
LEU A 121
 None
 0.63A 6exiA-1t90A:
4.6		 6exiA-1t90A:
13.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tll NITRIC-OXIDE
SYNTHASE, BRAIN

(Rattus
norvegicus) 		PF00175
(NAD_binding_1)
PF00258
(Flavodoxin_1)
PF00667
(FAD_binding_1) 		3 LEU A1359
ASN A1388
LEU A1339
 None
 0.70A 6exiA-1tllA:
4.3		 6exiA-1tllA:
8.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tp9 PEROXIREDOXIN

(Populus
trichocarpa) 		PF08534
(Redoxin) 		3 LEU A  10
ASN A 143
LEU A 114
 None
 0.65A 6exiA-1tp9A:
undetectable		 6exiA-1tp9A:
24.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tv8 MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
A

(Staphylococcus
aureus) 		PF04055
(Radical_SAM)
PF06463
(Mob_synth_C)
PF13394
(Fer4_14) 		3 LEU A  83
ASN A 124
LEU A 108
 None
 0.57A 6exiA-1tv8A:
undetectable		 6exiA-1tv8A:
12.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1txo PUTATIVE BACTERIAL
ENZYME

(Mycobacterium
tuberculosis) 		PF13672
(PP2C_2) 		3 LEU A 175
ASN A  81
LEU A  57
 None
 0.69A 6exiA-1txoA:
undetectable		 6exiA-1txoA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u4q SPECTRIN ALPHA
CHAIN, BRAIN

(Gallus gallus) 		PF00435
(Spectrin) 		3 LEU A1850
ASN A1839
LEU A1771
 None
 0.65A 6exiA-1u4qA:
undetectable		 6exiA-1u4qA:
14.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u6g TIP120 PROTEIN

(Homo sapiens) 		PF08623
(TIP120) 		3 LEU C 655
ASN C 680
LEU C 685
 None
 0.66A 6exiA-1u6gC:
undetectable		 6exiA-1u6gC:
6.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u6g TIP120 PROTEIN

(Homo sapiens) 		PF08623
(TIP120) 		3 LEU C 896
ASN C 887
LEU C 880
 None
 0.71A 6exiA-1u6gC:
undetectable		 6exiA-1u6gC:
6.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ucs ANTIFREEZE PEPTIDE
RD1

(Lycodichthys
dearborni) 		PF08666
(SAF) 		3 LEU A  10
ASN A  46
LEU A  17
 None
 0.71A 6exiA-1ucsA:
undetectable		 6exiA-1ucsA:
24.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uus STAT PROTEIN

(Dictyostelium
discoideum) 		PF00017
(SH2)
PF09267
(Dict-STAT-coil) 		3 LEU A 343
ASN A 274
LEU A 288
 None
 0.60A 6exiA-1uusA:
undetectable		 6exiA-1uusA:
9.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uww ENDOGLUCANASE

(Bacillus akibai) 		PF03424
(CBM_17_28) 		3 LEU A  53
ASN A 165
LEU A  18
 None
 0.68A 6exiA-1uwwA:
undetectable		 6exiA-1uwwA:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v8y ADP-RIBOSE
PYROPHOSPHATASE

(Thermus
thermophilus) 		PF00293
(NUDIX) 		3 LEU A  76
ASN A 117
LEU A  83
 None
 0.68A 6exiA-1v8yA:
undetectable		 6exiA-1v8yA:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vbg PYRUVATE,ORTHOPHOSPH
ATE DIKINASE

(Zea mays) 		PF00391
(PEP-utilizers)
PF01326
(PPDK_N)
PF02896
(PEP-utilizers_C) 		3 LEU A  66
ASN A 241
LEU A 207
 None
 0.56A 6exiA-1vbgA:
undetectable		 6exiA-1vbgA:
6.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vi4 REGULATOR OF
RIBONUCLEASE
ACTIVITY A PROTEIN 1

(Vibrio cholerae) 		PF03737
(RraA-like) 		3 LEU A 113
ASN A 136
LEU A  20
 None
 0.57A 6exiA-1vi4A:
undetectable		 6exiA-1vi4A:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vlv ORNITHINE
CARBAMOYLTRANSFERASE

(Thermotoga
maritima) 		PF00185
(OTCace)
PF02729
(OTCace_N) 		3 LEU A 172
ASN A 149
LEU A 153
 None
 0.62A 6exiA-1vlvA:
8.7		 6exiA-1vlvA:
13.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w55 ISPD/ISPF
BIFUNCTIONAL ENZYME

(Campylobacter
jejuni) 		PF01128
(IspD)
PF02542
(YgbB) 		3 LEU A 249
ASN A 302
LEU A 329
 None
 0.59A 6exiA-1w55A:
undetectable		 6exiA-1w55A:
13.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xec DECORIN

(Bos taurus) 		PF01462
(LRRNT)
PF13855
(LRR_8) 		3 LEU A 199
ASN A 238
LEU A 245
 None
 0.66A 6exiA-1xecA:
undetectable		 6exiA-1xecA:
13.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xhb POLYPEPTIDE
N-ACETYLGALACTOSAMIN
YLTRANSFERASE 1

(Mus musculus) 		PF00535
(Glycos_transf_2)
PF00652
(Ricin_B_lectin) 		3 LEU A 483
ASN A 436
LEU A 550
 None
 0.66A 6exiA-1xhbA:
undetectable		 6exiA-1xhbA:
8.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xl8 PEROXISOMAL
CARNITINE
O-OCTANOYLTRANSFERAS
E

(Mus musculus) 		PF00755
(Carn_acyltransf) 		3 LEU A 133
ASN A 312
LEU A 162
 None
 0.55A 6exiA-1xl8A:
undetectable		 6exiA-1xl8A:
11.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xpo RHO TRANSCRIPTION
TERMINATION FACTOR

(Escherichia
coli) 		PF00006
(ATP-synt_ab)
PF07497
(Rho_RNA_bind)
PF07498
(Rho_N) 		3 LEU A  39
ASN A   8
LEU A  14
 None
 0.62A 6exiA-1xpoA:
undetectable		 6exiA-1xpoA:
10.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xtj PROBABLE
ATP-DEPENDENT RNA
HELICASE P47

(Homo sapiens) 		PF00270
(DEAD)
PF00271
(Helicase_C) 		3 LEU A 285
ASN A 361
LEU A 278
 None
 0.67A 6exiA-1xtjA:
2.4		 6exiA-1xtjA:
10.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xxi DNA POLYMERASE III
SUBUNIT GAMMA

(Escherichia
coli) 		PF12169
(DNA_pol3_gamma3)
PF13177
(DNA_pol3_delta2) 		3 LEU B 354
ASN B 269
LEU B 252
 None
 0.67A 6exiA-1xxiB:
undetectable		 6exiA-1xxiB:
15.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yfj DNA ADENINE
METHYLASE

(Escherichia
virus T4) 		PF02086
(MethyltransfD12) 		3 LEU A 175
ASN A 195
LEU A 209
 None
 0.70A 6exiA-1yfjA:
3.7		 6exiA-1yfjA:
14.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ywf PHOSPHOTYROSINE
PROTEIN PHOSPHATASE
PTPB

(Mycobacterium
tuberculosis) 		PF13350
(Y_phosphatase3) 		3 LEU A  47
ASN A  11
LEU A  33
 None
 0.64A 6exiA-1ywfA:
undetectable		 6exiA-1ywfA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ac5 MAP
KINASE-INTERACTING
SERINE/THREONINE
KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		3 LEU A 288
ASN A 141
LEU A 206
 None
 0.66A 6exiA-2ac5A:
undetectable		 6exiA-2ac5A:
13.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2amc PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN
PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN

(Thermus
thermophilus;
Thermus
thermophilus) 		PF01409
(tRNA-synt_2d)
PF01409
(tRNA-synt_2d)
PF01588
(tRNA_bind)
PF03147
(FDX-ACB)
PF03483
(B3_4)
PF03484
(B5) 		3 LEU B 544
ASN A 133
LEU A 161
 None
 0.68A 6exiA-2amcB:
undetectable		 6exiA-2amcB:
9.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ass S-PHASE
KINASE-ASSOCIATED
PROTEIN 2

(Homo sapiens) 		PF12937
(F-box-like) 		3 LEU B2248
ASN B2289
LEU B2258
 None
 0.70A 6exiA-2assB:
undetectable		 6exiA-2assB:
12.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ass S-PHASE
KINASE-ASSOCIATED
PROTEIN 2

(Homo sapiens) 		PF12937
(F-box-like) 		3 LEU B2305
ASN B2262
LEU B2252
 None
 0.59A 6exiA-2assB:
undetectable		 6exiA-2assB:
12.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bdw HYPOTHETICAL PROTEIN
K11E8.1D

(Caenorhabditis
elegans) 		PF00069
(Pkinase) 		3 LEU A 206
ASN A  71
LEU A 136
 None
 0.69A 6exiA-2bdwA:
undetectable		 6exiA-2bdwA:
12.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bgh VINORINE SYNTHASE

(Rauvolfia
serpentina) 		PF02458
(Transferase) 		3 LEU A 332
ASN A 277
LEU A 298
 None
 0.64A 6exiA-2bghA:
undetectable		 6exiA-2bghA:
10.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c6x CITRATE SYNTHASE 1

(Bacillus
subtilis) 		PF00285
(Citrate_synt) 		3 LEU A 323
ASN A 150
LEU A 168
 None
 0.59A 6exiA-2c6xA:
undetectable		 6exiA-2c6xA:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cfo GLUTAMYL-TRNA
SYNTHETASE

(Synechococcus
elongatus) 		PF00749
(tRNA-synt_1c) 		3 LEU A 292
ASN A 320
LEU A 289
 None
 0.69A 6exiA-2cfoA:
undetectable		 6exiA-2cfoA:
12.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d07 G/T
MISMATCH-SPECIFIC
THYMINE DNA
GLYCOSYLASE

(Homo sapiens) 		PF03167
(UDG) 		3 LEU A 132
ASN A 191
LEU A 219
 None
 0.66A 6exiA-2d07A:
undetectable		 6exiA-2d07A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dla 397AA LONG
HYPOTHETICAL PROTEIN

(Pyrococcus
horikoshii) 		PF04104
(DNA_primase_lrg) 		3 LEU A 169
ASN A 180
LEU A  90
 None
 0.68A 6exiA-2dlaA:
undetectable		 6exiA-2dlaA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2es3 THROMBOSPONDIN-1

(Homo sapiens) 		PF02210
(Laminin_G_2) 		3 LEU A 130
ASN A 158
LEU A 112
 None
 0.70A 6exiA-2es3A:
undetectable		 6exiA-2es3A:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g9b CALBINDIN

(Rattus
norvegicus) 		PF13405
(EF-hand_6)
PF13499
(EF-hand_7) 		3 LEU A  54
ASN A  38
LEU A  78
 None
 0.68A 6exiA-2g9bA:
undetectable		 6exiA-2g9bA:
13.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g9w CONSERVED
HYPOTHETICAL PROTEIN

(Mycobacterium
tuberculosis) 		PF03965
(Penicillinase_R) 		3 LEU A  18
ASN A  56
LEU A   4
 None
 0.59A 6exiA-2g9wA:
undetectable		 6exiA-2g9wA:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gie TYPE II RESTRICTION
ENZYME HINCII

(Haemophilus
influenzae) 		PF09226
(Endonuc-HincII) 		3 LEU A 169
ASN A  48
LEU A 117
 None
 0.65A 6exiA-2gieA:
undetectable		 6exiA-2gieA:
14.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gu0 NONSTRUCTURAL
PROTEIN 2

(Rotavirus C) 		PF02509
(Rota_NS35) 		3 LEU A  69
ASN A 141
LEU A  83
 None
 0.71A 6exiA-2gu0A:
undetectable		 6exiA-2gu0A:
14.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gzs IROE PROTEIN

(Escherichia
coli) 		PF00756
(Esterase) 		3 LEU A 103
ASN A 292
LEU A 300
 None
 0.68A 6exiA-2gzsA:
2.8		 6exiA-2gzsA:
16.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h00 METHYLTRANSFERASE 10
DOMAIN CONTAINING
PROTEIN

(Homo sapiens) 		PF05971
(Methyltransf_10) 		3 LEU A  23
ASN A  47
LEU A  87
 None
 0.68A 6exiA-2h00A:
6.7		 6exiA-2h00A:
15.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h00 METHYLTRANSFERASE 10
DOMAIN CONTAINING
PROTEIN

(Homo sapiens) 		PF05971
(Methyltransf_10) 		3 LEU A  23
ASN A  88
LEU A 114
 None
 0.56A 6exiA-2h00A:
6.7		 6exiA-2h00A:
15.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hpa PROTEIN (ACID
PHOSPHATASE)

(Homo sapiens) 		PF00328
(His_Phos_2) 		3 LEU A1312
ASN A1233
LEU A1264
 None
 0.65A 6exiA-2hpaA:
undetectable		 6exiA-2hpaA:
15.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2huj LIN2004 PROTEIN

(Listeria
innocua) 		PF08807
(DUF1798) 		3 LEU A  67
ASN A  78
LEU A  52
 None
 0.71A 6exiA-2hujA:
undetectable		 6exiA-2hujA:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i05 DNA REPLICATION
TERMINUS
SITE-BINDING PROTEIN

(Escherichia
coli) 		PF05472
(Ter) 		3 LEU A  28
ASN A 264
LEU A  34
 None
 0.66A 6exiA-2i05A:
undetectable		 6exiA-2i05A:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ilr FANCONI ANEMIA GROUP
E PROTEIN

(Homo sapiens) 		PF11510
(FA_FANCE) 		3 LEU A 492
ASN A 503
LEU A 512
 None
 0.54A 6exiA-2ilrA:
undetectable		 6exiA-2ilrA:
14.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jam CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE 1G

(Homo sapiens) 		PF00069
(Pkinase) 		3 LEU A 213
ASN A  80
LEU A 145
 None
 0.67A 6exiA-2jamA:
undetectable		 6exiA-2jamA:
13.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jeo URIDINE-CYTIDINE
KINASE 1

(Homo sapiens) 		PF00485
(PRK) 		3 LEU A 231
ASN A  50
LEU A 136
 None
 0.68A 6exiA-2jeoA:
undetectable		 6exiA-2jeoA:
14.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ko6 UNCHARACTERIZED
PROTEIN YIHD

(Shigella
flexneri) 		PF06288
(DUF1040) 		3 LEU A  26
ASN A   7
LEU A  13
 None
 0.59A 6exiA-2ko6A:
undetectable		 6exiA-2ko6A:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2l3f UNCHARACTERIZED
PROTEIN

(Methanosarcina
acetivorans) 		PF03167
(UDG) 		3 LEU A 134
ASN A  68
LEU A  72
 None
 0.68A 6exiA-2l3fA:
undetectable		 6exiA-2l3fA:
19.38