SIMILAR PATTERNS OF AMINO ACIDS FOR 6EXI_A_ADNA502_0
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1fwx | NITROUS OXIDEREDUCTASE (Paracoccusdenitrificans) |
PF13473(Cupredoxin_1) | 5 | THR A 202HIS A 82ASN A 273GLY A 271HIS A 325 | NoneNone CL A4901 (-3.5A) CL A4901 ( 3.7A)CUZ A4801 ( 3.3A) | 1.48A | 6exiA-1fwxA:undetectable | 6exiA-1fwxA:8.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1q8f | PYRIMIDINENUCLEOSIDE HYDROLASE (Escherichiacoli) |
PF01156(IU_nuc_hydro) | 5 | HIS A 239THR A 242HIS A 82ASN A 166GLY A 151 | GOL A3001 ( 3.9A)NoneGOL A3005 (-3.9A)GOL A3001 (-3.3A)None | 1.45A | 6exiA-1q8fA:7.5 | 6exiA-1q8fA:15.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1tve | HOMOSERINEDEHYDROGENASE (Saccharomycescerevisiae) |
PF00742(Homoserine_dh)PF03447(NAD_binding_3) | 5 | THR A 225ASN A 216LEU A 218GLY A 217PHE A 241 | None | 1.37A | 6exiA-1tveA:2.3 | 6exiA-1tveA:17.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1v8b | ADENOSYLHOMOCYSTEINASE (Plasmodiumfalciparum) |
PF00670(AdoHcyase_NAD)PF05221(AdoHcyase) | 9 | HIS A 54THR A 56ASP A 234ASN A 391LEU A 392GLY A 397HIS A 398MET A 403PHE A 407 | ADN A 502 (-4.1A)ADN A 502 (-3.0A)ADN A 502 (-2.8A)NAD A 501 (-3.0A)ADN A 502 ( 4.9A)ADN A 502 ( 3.7A)ADN A 502 ( 3.5A)ADN A 502 (-3.6A)None | 0.33A | 6exiA-1v8bA:59.1 | 6exiA-1v8bA:11.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2fyw | CONSERVEDHYPOTHETICAL PROTEIN (Streptococcuspneumoniae) |
PF01784(NIF3) | 5 | HIS A 225ASP A 103HIS A 65GLY A 185PHE A 113 | None | 1.48A | 6exiA-2fywA:undetectable | 6exiA-2fywA:16.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2g5c | PREPHENATEDEHYDROGENASE (Aquifexaeolicus) |
PF02153(PDH) | 5 | THR A 120LEU A 172GLY A 145MET A 96PHE A 94 | None | 1.45A | 6exiA-2g5cA:8.0 | 6exiA-2g5cA:14.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2g5c | PREPHENATEDEHYDROGENASE (Aquifexaeolicus) |
PF02153(PDH) | 5 | THR A 120LEU A 172GLY A 146MET A 96PHE A 94 | None | 1.13A | 6exiA-2g5cA:8.0 | 6exiA-2g5cA:14.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2gj4 | GLYCOGENPHOSPHORYLASE,MUSCLE FORM (Oryctolaguscuniculus) |
PF00343(Phosphorylase) | 5 | THR A 671THR A 668ASN A 284LEU A 380HIS A 571 | None | 1.17A | 6exiA-2gj4A:4.9 | 6exiA-2gj4A:7.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2jdx | PROTEIN(L-ARGININE:GLYCINEAMIDINOTRANSFERASE) (Homo sapiens) |
no annotation | 5 | ASP A 170ASN A 361LEU A 358GLY A 404MET A 167 | None | 1.04A | 6exiA-2jdxA:undetectable | 6exiA-2jdxA:10.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2pq6 | UDP-GLUCURONOSYL/UDP-GLUCOSYLTRANSFERASE (Medicagotruncatula) |
PF00201(UDPGT) | 5 | THR A 305ASP A 402ASN A 382GLY A 20PHE A 400 | None | 1.34A | 6exiA-2pq6A:4.6 | 6exiA-2pq6A:11.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2pq6 | UDP-GLUCURONOSYL/UDP-GLUCOSYLTRANSFERASE (Medicagotruncatula) |
PF00201(UDPGT) | 5 | THR A 305THR A 306ASP A 402ASN A 382GLY A 20 | None | 1.48A | 6exiA-2pq6A:4.6 | 6exiA-2pq6A:11.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2vmf | BETA-MANNOSIDASE (Bacteroidesthetaiotaomicron) |
PF00703(Glyco_hydro_2) | 5 | HIS A 511ASP A 529ASN A 460GLY A 459PHE A 508 | EDO A1872 (-4.6A)NoneNoneNoneNone | 1.36A | 6exiA-2vmfA:undetectable | 6exiA-2vmfA:7.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2w5s | PROCESSED GLYCEROLPHOSPHATELIPOTEICHOIC ACIDSYNTHASE (Staphylococcusaureus) |
PF00884(Sulfatase) | 5 | HIS A 416THR A 420ASP A 388LEU A 384GLY A 385 | GP9 A1644 (-4.0A)NoneNoneNoneNone | 1.48A | 6exiA-2w5sA:undetectable | 6exiA-2w5sA:17.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2wab | ENDOGLUCANASE E (Ruminiclostridiumthermocellum) |
PF00657(Lipase_GDSL) | 5 | HIS A 316THR A 315GLY A 306HIS A 310MET A 263 | NoneGOL A1341 (-3.7A)NoneBGC A1338 (-4.0A)BGC A1337 (-4.5A) | 1.28A | 6exiA-2wabA:5.4 | 6exiA-2wabA:14.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2wab | ENDOGLUCANASE E (Ruminiclostridiumthermocellum) |
PF00657(Lipase_GDSL) | 5 | THR A 315GLN A 299GLY A 306HIS A 310MET A 263 | GOL A1341 (-3.7A)NoneNoneBGC A1338 (-4.0A)BGC A1337 (-4.5A) | 1.36A | 6exiA-2wabA:5.4 | 6exiA-2wabA:14.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2xsr | CATECHOL 1,2DIOXYGENASE (Acinetobacterradioresistens) |
PF00775(Dioxygenase_C)PF04444(Dioxygenase_N) | 5 | ASP A 246LEU A 207GLY A 214HIS A 213PHE A 250 | None | 1.43A | 6exiA-2xsrA:undetectable | 6exiA-2xsrA:13.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ayf | NITRIC OXIDEREDUCTASE (Geobacillusstearothermophilus) |
PF00115(COX1) | 5 | THR A 99THR A 217ASP A 500GLY A 89HIS A 90 | None | 1.30A | 6exiA-3ayfA:undetectable | 6exiA-3ayfA:9.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3azq | AMINOPEPTIDASE (Streptomycesmorookaense) |
PF00326(Peptidase_S9) | 5 | THR A 531ASP A 445LEU A 533GLY A 509PHE A 449 | None | 1.27A | 6exiA-3azqA:2.7 | 6exiA-3azqA:8.41 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3ce6 | ADENOSYLHOMOCYSTEINASE (Mycobacteriumtuberculosis) |
PF00670(AdoHcyase_NAD)PF05221(AdoHcyase) | 11 | HIS A 69THR A 71GLN A 73THR A 74ASP A 252ASN A 409LEU A 410GLY A 415HIS A 416MET A 421PHE A 425 | ADN A 500 (-4.0A)ADN A 500 (-2.8A)ADN A 500 (-3.6A)ADN A 500 (-4.5A)ADN A 500 (-2.7A)NAD A 550 (-3.0A)ADN A 500 ( 4.8A)ADN A 500 ( 3.6A)ADN A 500 ( 3.6A)ADN A 500 (-3.7A)ADN A 500 (-4.8A) | 0.26A | 6exiA-3ce6A:59.6 | 6exiA-3ce6A:60.71 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3ce6 | ADENOSYLHOMOCYSTEINASE (Mycobacteriumtuberculosis) |
PF00670(AdoHcyase_NAD)PF05221(AdoHcyase) | 8 | HIS A 69THR A 71GLN A 73THR A 74HIS A 363LEU A 410GLY A 415PHE A 425 | ADN A 500 (-4.0A)ADN A 500 (-2.8A)ADN A 500 (-3.6A)ADN A 500 (-4.5A)ADN A 500 ( 3.7A)ADN A 500 ( 4.8A)ADN A 500 ( 3.6A)ADN A 500 (-4.8A) | 1.00A | 6exiA-3ce6A:59.6 | 6exiA-3ce6A:60.71 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3g1u | ADENOSYLHOMOCYSTEINASE (Leishmaniamajor) |
PF00670(AdoHcyase_NAD)PF05221(AdoHcyase) | 10 | HIS A 52THR A 54GLN A 56THR A 57ASN A 345LEU A 346GLY A 351HIS A 352MET A 357PHE A 361 | ADN A 438 (-4.0A)ADN A 438 (-2.8A)ADN A 438 (-3.8A)ADN A 438 (-4.6A)NAD A 439 (-3.1A)ADN A 438 ( 4.8A)ADN A 438 ( 3.8A)ADN A 438 ( 3.6A)ADN A 438 (-3.7A)None | 0.18A | 6exiA-3g1uA:56.5 | 6exiA-3g1uA:71.62 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3g1u | ADENOSYLHOMOCYSTEINASE (Leishmaniamajor) |
PF00670(AdoHcyase_NAD)PF05221(AdoHcyase) | 8 | HIS A 52THR A 54GLN A 56THR A 57HIS A 300LEU A 346GLY A 351PHE A 361 | ADN A 438 (-4.0A)ADN A 438 (-2.8A)ADN A 438 (-3.8A)ADN A 438 (-4.6A)ADN A 438 ( 4.0A)ADN A 438 ( 4.8A)ADN A 438 ( 3.8A)None | 1.01A | 6exiA-3g1uA:56.5 | 6exiA-3g1uA:71.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ggg | PREPHENATEDEHYDROGENASE (Aquifexaeolicus) |
no annotation | 5 | THR D 120LEU D 172GLY D 145MET D 96PHE D 94 | None | 1.37A | 6exiA-3gggD:3.6 | 6exiA-3gggD:12.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ggg | PREPHENATEDEHYDROGENASE (Aquifexaeolicus) |
no annotation | 5 | THR D 120LEU D 172GLY D 146MET D 96PHE D 94 | None | 1.04A | 6exiA-3gggD:3.6 | 6exiA-3gggD:12.88 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3glq | ADENOSYLHOMOCYSTEINASE (Burkholderiapseudomallei) |
PF00670(AdoHcyase_NAD)PF05221(AdoHcyase) | 11 | HIS A 62THR A 64GLN A 66THR A 67ASP A 233ASN A 387LEU A 388GLY A 393HIS A 394MET A 399PHE A 403 | RAB A 602 (-3.8A)RAB A 602 (-2.7A)RAB A 602 (-3.9A)RAB A 602 (-4.5A)RAB A 602 (-2.5A)NAD A 601 (-3.0A)RAB A 602 ( 4.7A)RAB A 602 ( 3.8A)NAD A 601 ( 3.6A)RAB A 602 (-3.6A)None | 0.27A | 6exiA-3glqA:60.2 | 6exiA-3glqA:61.11 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3glq | ADENOSYLHOMOCYSTEINASE (Burkholderiapseudomallei) |
PF00670(AdoHcyase_NAD)PF05221(AdoHcyase) | 8 | HIS A 62THR A 64GLN A 66THR A 67HIS A 344LEU A 388GLY A 393PHE A 403 | RAB A 602 (-3.8A)RAB A 602 (-2.7A)RAB A 602 (-3.9A)RAB A 602 (-4.5A)RAB A 602 ( 3.5A)RAB A 602 ( 4.7A)RAB A 602 ( 3.8A)None | 1.00A | 6exiA-3glqA:60.2 | 6exiA-3glqA:61.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3h9u | ADENOSYLHOMOCYSTEINASE (Trypanosomabrucei) |
PF00670(AdoHcyase_NAD)PF05221(AdoHcyase) | 11 | HIS A 52THR A 54GLN A 56THR A 57ASP A 189ASN A 345LEU A 346GLY A 351HIS A 352MET A 357PHE A 361 | ADN A 439 ( 4.7A)ADN A 439 (-2.7A)ADN A 439 (-3.6A)ADN A 439 (-4.7A)NAD A 438 ( 4.4A)NAD A 438 (-2.9A)ADN A 439 ( 4.7A)ADN A 439 (-3.5A)ADN A 439 ( 3.3A)ADN A 439 ( 3.7A)None | 0.29A | 6exiA-3h9uA:56.3 | 6exiA-3h9uA:13.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3h9u | ADENOSYLHOMOCYSTEINASE (Trypanosomabrucei) |
PF00670(AdoHcyase_NAD)PF05221(AdoHcyase) | 7 | HIS A 52THR A 54GLN A 56THR A 57HIS A 300LEU A 346PHE A 361 | ADN A 439 ( 4.7A)ADN A 439 (-2.7A)ADN A 439 (-3.6A)ADN A 439 (-4.7A)NoneADN A 439 ( 4.7A)None | 1.05A | 6exiA-3h9uA:56.3 | 6exiA-3h9uA:13.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3k5h | PHOSPHORIBOSYL-AMINOIMIDAZOLECARBOXYLASE (Aspergillusclavatus) |
PF01262(AlaDh_PNT_C)PF02222(ATP-grasp) | 5 | HIS A 273THR A 209GLY A 276HIS A 277MET A 313 | None | 1.46A | 6exiA-3k5hA:undetectable | 6exiA-3k5hA:13.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3n58 | ADENOSYLHOMOCYSTEINASE (Brucellaabortus) |
PF00670(AdoHcyase_NAD)PF05221(AdoHcyase) | 11 | HIS A 55THR A 57GLN A 59THR A 60ASP A 226ASN A 380LEU A 381GLY A 386HIS A 387MET A 392PHE A 396 | ADN A 500 (-4.0A)ADN A 500 (-2.8A) K A 2 ( 3.3A)ADN A 500 (-4.6A)ADN A 500 ( 2.6A)NAD A 550 (-3.0A)ADN A 500 ( 4.8A)ADN A 500 (-3.7A)ADN A 500 (-3.4A)ADN A 500 (-3.7A)None | 0.23A | 6exiA-3n58A:61.1 | 6exiA-3n58A:14.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3n58 | ADENOSYLHOMOCYSTEINASE (Brucellaabortus) |
PF00670(AdoHcyase_NAD)PF05221(AdoHcyase) | 8 | HIS A 55THR A 57GLN A 59THR A 60HIS A 337LEU A 381GLY A 386PHE A 396 | ADN A 500 (-4.0A)ADN A 500 (-2.8A) K A 2 ( 3.3A)ADN A 500 (-4.6A)ADN A 500 ( 3.6A)ADN A 500 ( 4.8A)ADN A 500 (-3.7A)None | 1.01A | 6exiA-3n58A:61.1 | 6exiA-3n58A:14.32 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3one | ADENOSYLHOMOCYSTEINASE (Lupinus luteus) |
PF00670(AdoHcyase_NAD)PF05221(AdoHcyase) | 11 | HIS A 62THR A 64GLN A 66THR A 67ASP A 239ASN A 397LEU A 398GLY A 403HIS A 404MET A 409PHE A 413 | ADE A 506 (-4.6A)ADE A 506 (-2.8A)ADE A 506 (-3.8A)ADE A 506 (-4.5A)NAD A 501 ( 4.5A)NAD A 501 (-3.0A)ADE A 506 ( 4.7A)ADE A 506 ( 3.6A)ADE A 506 (-3.4A)ADE A 506 (-3.8A)ADE A 506 (-4.9A) | 0.28A | 6exiA-3oneA:56.4 | 6exiA-3oneA:64.20 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3one | ADENOSYLHOMOCYSTEINASE (Lupinus luteus) |
PF00670(AdoHcyase_NAD)PF05221(AdoHcyase) | 8 | HIS A 62THR A 64GLN A 66THR A 67HIS A 350LEU A 398GLY A 403PHE A 413 | ADE A 506 (-4.6A)ADE A 506 (-2.8A)ADE A 506 (-3.8A)ADE A 506 (-4.5A)NoneADE A 506 ( 4.7A)ADE A 506 ( 3.6A)ADE A 506 (-4.9A) | 1.03A | 6exiA-3oneA:56.4 | 6exiA-3oneA:64.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3t3o | METAL DEPENDENTHYDROLASE (Thermusthermophilus) |
PF07521(RMMBL)PF12706(Lactamase_B_2) | 5 | GLN A 404ASP A 204ASN A 24GLY A 17HIS A 398 | NoneNone ZN A 600 ( 4.7A)None ZN A 600 (-3.6A) | 1.46A | 6exiA-3t3oA:undetectable | 6exiA-3t3oA:11.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4c25 | L-FUCULOSE PHOSPHATEALDOLASE (Streptococcuspneumoniae) |
PF00596(Aldolase_II) | 5 | THR A 96THR A 21HIS A 78GLY A 156HIS A 155 | NoneNoneNoneNone ZN A 301 ( 3.2A) | 1.39A | 6exiA-4c25A:undetectable | 6exiA-4c25A:17.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4fxq | PUTATIVEADP-RIBOSYLTRANSFERASE CERTHRAX (Bacillus cereus) |
PF03496(ADPrib_exo_Tox)PF07737(ATLF) | 5 | THR A 439THR A 379ASP A 295GLY A 437HIS A 383 | None | 1.32A | 6exiA-4fxqA:undetectable | 6exiA-4fxqA:11.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4hyn | CHEC, INHIBITOR OFMCP METHYLATION /FLIN FUSION PROTEIN (Thermotogamaritima) |
PF04509(CheC) | 5 | GLN A 202HIS A 57ASN A 38GLY A 37PHE A 200 | None | 1.31A | 6exiA-4hynA:undetectable | 6exiA-4hynA:20.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4l7z | HPCH/HPAI ALDOLASE (Chloroflexusaurantiacus) |
PF03328(HpcH_HpaI) | 5 | GLN A 220LEU A 223GLY A 199HIS A 200PHE A 218 | None | 1.33A | 6exiA-4l7zA:undetectable | 6exiA-4l7zA:15.02 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4lvc | S-ADENOSYL-L-HOMOCYSTEINE HYDROLASE(SAHASE) (Bradyrhizobiumelkanii) |
PF00670(AdoHcyase_NAD)PF05221(AdoHcyase) | 11 | HIS A 58THR A 60GLN A 62THR A 63ASP A 231ASN A 385LEU A 386GLY A 391HIS A 392MET A 397PHE A 401 | ADN A 501 (-4.0A)ADN A 501 (-2.8A)NH4 A 502 ( 3.1A)ADN A 501 (-4.5A)ADN A 501 (-3.1A)NAD A 503 (-3.1A)ADN A 501 ( 4.7A)ADN A 501 (-3.6A)ADN A 501 (-3.5A)ADN A 501 (-3.7A)ADN A 501 (-4.8A) | 0.28A | 6exiA-4lvcA:68.4 | 6exiA-4lvcA:100.00 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4lvc | S-ADENOSYL-L-HOMOCYSTEINE HYDROLASE(SAHASE) (Bradyrhizobiumelkanii) |
PF00670(AdoHcyase_NAD)PF05221(AdoHcyase) | 8 | HIS A 58THR A 60GLN A 62THR A 63HIS A 342LEU A 386GLY A 391PHE A 401 | ADN A 501 (-4.0A)ADN A 501 (-2.8A)NH4 A 502 ( 3.1A)ADN A 501 (-4.5A)ADN A 501 ( 3.7A)ADN A 501 ( 4.7A)ADN A 501 (-3.6A)ADN A 501 (-4.8A) | 1.02A | 6exiA-4lvcA:68.4 | 6exiA-4lvcA:100.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4mo9 | PERIPLASMIC BINDINGPROTEIN (Veillonellaparvula) |
PF01497(Peripla_BP_2) | 5 | ASP A 77LEU A 314GLY A 313MET A 78PHE A 82 | None | 1.37A | 6exiA-4mo9A:3.6 | 6exiA-4mo9A:14.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4oe5 | DELTA-1-PYRROLINE-5-CARBOXYLATEDEHYDROGENASE,MITOCHONDRIAL (Homo sapiens) |
PF00171(Aldedh) | 5 | THR A 285ASN A 319LEU A 478GLY A 317PHE A 212 | None | 1.15A | 6exiA-4oe5A:undetectable | 6exiA-4oe5A:9.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4p08 | COCAINE ESTERASE (Rhodococcus sp.MB1) |
PF02129(Peptidase_S15)PF08530(PepX_C) | 5 | THR A 510THR A 442ASP A 343HIS A 518LEU A 476 | None | 1.40A | 6exiA-4p08A:3.6 | 6exiA-4p08A:10.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4s2t | PROTEIN APP-1 (Caenorhabditiselegans) |
PF00557(Peptidase_M24)PF01321(Creatinase_N)PF16188(Peptidase_M24_C)PF16189(Creatinase_N_2) | 5 | HIS P 483ASP P 424HIS P 392GLY P 486HIS P 487 | None ZN P 701 (-2.4A)NoneNone ZN P 702 ( 3.7A) | 1.49A | 6exiA-4s2tP:undetectable | 6exiA-4s2tP:9.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4v15 | D-THREONINE ALDOLASE (Achromobacterxylosoxidans) |
PF01168(Ala_racemase_N)PF14031(D-ser_dehydrat) | 5 | HIS A 347THR A 300THR A 351HIS A 193GLY A 304 | MN A1382 (-3.4A)NoneNoneNoneNone | 1.45A | 6exiA-4v15A:undetectable | 6exiA-4v15A:15.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xwt | DR2417 (Deinococcusradiodurans) |
PF00753(Lactamase_B)PF07521(RMMBL) | 5 | GLN A 409ASP A 209ASN A 33GLY A 26HIS A 403 | NoneNone ZN A 602 ( 4.5A)None ZN A 602 (-3.2A) | 1.39A | 6exiA-4xwtA:undetectable | 6exiA-4xwtA:10.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ycz | FUSION PROTEIN OFSEC13 AND NUP145C (Thermothelomycesthermophila) |
PF00400(WD40)PF12110(Nup96) | 5 | ASP A 141HIS A1670GLY A1744HIS A1743PHE A 139 | None | 1.41A | 6exiA-4yczA:undetectable | 6exiA-4yczA:7.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5h83 | HETEROYOHIMBINESYNTHASE HYS (Catharanthusroseus) |
PF00107(ADH_zinc_N)PF08240(ADH_N) | 5 | HIS A 127ASP A 54GLY A 99HIS A 73PHE A 69 | NoneNoneNone ZN A 901 (-3.1A)None | 1.33A | 6exiA-5h83A:6.6 | 6exiA-5h83A:10.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5i3a | TYROSINASE (Bacillusmegaterium) |
PF00264(Tyrosinase) | 5 | GLN A 193HIS A 231ASN A 205GLY A 196PHE A 190 | None ZN A 302 (-3.1A)HQE A 303 (-3.4A)NoneNone | 1.19A | 6exiA-5i3aA:undetectable | 6exiA-5i3aA:14.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5i51 | TRANSKETOLASE (Scheffersomycesstipitis) |
PF00456(Transketolase_N)PF02779(Transket_pyr)PF02780(Transketolase_C) | 5 | ASN A 64LEU A 62GLY A 65HIS A 66PHE A 90 | NoneNoneNoneTPP A 701 ( 3.5A)None | 1.26A | 6exiA-5i51A:undetectable | 6exiA-5i51A:9.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5jkn | PROTEIN FAM63A (Homo sapiens) |
PF04424(MINDY_DUB) | 5 | THR A 295THR A 290LEU A 241GLY A 239HIS A 238 | None | 1.42A | 6exiA-5jknA:undetectable | 6exiA-5jknA:15.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5uq6 | TARTRATE-RESISTANTACID PHOSPHATASETYPE 5 (Sus scrofa) |
PF00149(Metallophos) | 5 | HIS A 195THR A 198ASP A 14ASN A 91HIS A 186 | PO4 A 404 (-3.8A)None FE A 402 ( 3.1A)PO4 A 404 ( 2.6A) FE A 403 ( 3.4A) | 1.26A | 6exiA-5uq6A:undetectable | 6exiA-5uq6A:15.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5uq6 | TARTRATE-RESISTANTACID PHOSPHATASETYPE 5 (Sus scrofa) |
PF00149(Metallophos) | 5 | HIS A 195THR A 198HIS A 223ASN A 91HIS A 186 | PO4 A 404 (-3.8A)None FE A 402 (-3.4A)PO4 A 404 ( 2.6A) FE A 403 ( 3.4A) | 1.38A | 6exiA-5uq6A:undetectable | 6exiA-5uq6A:15.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5utu | ADENOSYLHOMOCYSTEINASE (Cryptosporidiumparvum) |
PF00670(AdoHcyase_NAD)PF05221(AdoHcyase) | 10 | HIS A 53THR A 55THR A 58ASP A 245ASN A 403LEU A 404GLY A 409HIS A 410MET A 415PHE A 419 | SAH A 502 (-4.0A)SAH A 502 (-2.7A)SAH A 502 (-4.2A)SAH A 502 (-2.8A)NAD A 501 (-2.9A)SAH A 502 ( 4.7A)SAH A 502 ( 3.7A)SAH A 502 ( 3.5A)SAH A 502 (-3.6A)SAH A 502 (-4.8A) | 0.32A | 6exiA-5utuA:53.7 | 6exiA-5utuA:9.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5v96 | S-ADENOSYL-L-HOMOCYSTEINE HYDROLASE (Naegleriafowleri) |
PF00670(AdoHcyase_NAD)PF05221(AdoHcyase) | 10 | HIS A 59THR A 61THR A 64ASP A 231ASN A 388LEU A 389GLY A 394HIS A 395MET A 400PHE A 404 | ADN A 502 ( 3.9A)ADN A 502 (-2.9A)ADN A 502 (-4.4A)ADN A 502 (-2.8A)NAD A 501 (-3.1A)ADN A 502 ( 4.7A)ADN A 502 (-3.7A)ADN A 502 ( 3.4A)ADN A 502 (-3.8A)ADN A 502 (-4.9A) | 0.26A | 6exiA-5v96A:61.0 | 6exiA-5v96A:13.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5vrb | TRANSKETOLASE (Neisseriagonorrhoeae) |
PF00456(Transketolase_N)PF02779(Transket_pyr)PF02780(Transketolase_C) | 5 | ASN A 61LEU A 59GLY A 62HIS A 63PHE A 87 | OCS A 154 ( 4.3A)NoneNone CA A 704 ( 4.9A)None | 1.26A | 6exiA-5vrbA:undetectable | 6exiA-5vrbA:9.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5w4b | ADENOSYLHOMOCYSTEINASE (Homo sapiens) |
PF00670(AdoHcyase_NAD)PF05221(AdoHcyase) | 5 | ASN A 346LEU A 347GLY A 352HIS A 353MET A 358 | NAD A 501 (-3.1A)9W4 A 502 (-4.1A)9W4 A 502 ( 3.9A)NAD A 501 (-4.5A)9W4 A 502 (-3.6A) | 0.48A | 6exiA-5w4bA:48.4 | 6exiA-5w4bA:12.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5w4b | ADENOSYLHOMOCYSTEINASE (Homo sapiens) |
PF00670(AdoHcyase_NAD)PF05221(AdoHcyase) | 5 | ASP A 190ASN A 346LEU A 347GLY A 352HIS A 353 | NAD A 501 (-4.1A)NAD A 501 (-3.1A)9W4 A 502 (-4.1A)9W4 A 502 ( 3.9A)NAD A 501 (-4.5A) | 0.44A | 6exiA-5w4bA:48.4 | 6exiA-5w4bA:12.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5w4b | ADENOSYLHOMOCYSTEINASE (Homo sapiens) |
PF00670(AdoHcyase_NAD)PF05221(AdoHcyase) | 5 | HIS A 55THR A 57THR A 60ASP A 190PHE A 362 | 9W4 A 502 (-3.7A)9W4 A 502 (-2.9A)NoneNAD A 501 (-4.1A)None | 0.60A | 6exiA-5w4bA:48.4 | 6exiA-5w4bA:12.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5w4b | ADENOSYLHOMOCYSTEINASE (Homo sapiens) |
PF00670(AdoHcyase_NAD)PF05221(AdoHcyase) | 5 | HIS A 55THR A 57THR A 60MET A 358PHE A 362 | 9W4 A 502 (-3.7A)9W4 A 502 (-2.9A)None9W4 A 502 (-3.6A)None | 0.23A | 6exiA-5w4bA:48.4 | 6exiA-5w4bA:12.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5w4b | ADENOSYLHOMOCYSTEINASE (Homo sapiens) |
PF00670(AdoHcyase_NAD)PF05221(AdoHcyase) | 5 | THR A 57ASN A 346LEU A 347GLY A 352HIS A 353 | 9W4 A 502 (-2.9A)NAD A 501 (-3.1A)9W4 A 502 (-4.1A)9W4 A 502 ( 3.9A)NAD A 501 (-4.5A) | 0.79A | 6exiA-5w4bA:48.4 | 6exiA-5w4bA:12.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5yvs | ALCOHOLDEHYDROGENASE (candidatedivison MSBL1archaeonSCGC-AAA259E19) |
no annotation | 5 | THR A 147ASP A 102HIS A 288ASN A 264GLY A 261 | NoneNDP A 502 (-2.6A)NDP A 502 ( 3.0A)NDP A 502 ( 4.9A)None | 1.43A | 6exiA-5yvsA:undetectable | 6exiA-5yvsA:16.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ywp | JEV E PROTEIN (Japaneseencephalitisvirus) |
no annotation | 5 | THR A 317THR A 321ASP A 42GLY A 5PHE A 11 | None | 1.29A | 6exiA-5ywpA:undetectable | 6exiA-5ywpA:25.00 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 6aph | ADENOSYLHOMOCYSTEINASE (Elizabethkingiaanophelis) |
PF00670(AdoHcyase_NAD)PF05221(AdoHcyase) | 11 | HIS A 58THR A 60GLN A 62THR A 63ASP A 195ASN A 351LEU A 352GLY A 357HIS A 358MET A 363PHE A 367 | ADN A 501 (-3.9A)ADN A 501 (-2.8A)ADN A 501 (-3.8A)ADN A 501 (-4.5A)ADN A 501 (-2.7A)NAD A 500 (-3.1A)ADN A 501 ( 4.8A)ADN A 501 (-3.6A)ADN A 501 ( 3.5A)ADN A 501 (-3.7A)None | 0.24A | 6exiA-6aphA:56.9 | 6exiA-6aphA:69.51 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 6aph | ADENOSYLHOMOCYSTEINASE (Elizabethkingiaanophelis) |
PF00670(AdoHcyase_NAD)PF05221(AdoHcyase) | 8 | HIS A 58THR A 60GLN A 62THR A 63HIS A 306LEU A 352GLY A 357PHE A 367 | ADN A 501 (-3.9A)ADN A 501 (-2.8A)ADN A 501 (-3.8A)ADN A 501 (-4.5A)ADN A 501 ( 3.7A)ADN A 501 ( 4.8A)ADN A 501 (-3.6A)None | 0.99A | 6exiA-6aphA:56.9 | 6exiA-6aphA:69.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6f3m | - (-) |
no annotation | 11 | HIS B 61THR B 63GLN B 65THR B 66ASP B 198ASN B 375LEU B 376GLY B 381HIS B 382MET B 387PHE B 391 | ADN B 502 ( 4.0A)ADN B 502 (-2.8A) K B 504 ( 3.0A)ADN B 502 (-4.6A)ADN B 502 (-2.7A)NAD B 501 (-3.0A)ADN B 502 ( 4.8A)ADN B 502 ( 3.7A)ADN B 502 (-3.4A)ADN B 502 (-3.7A)ADN B 502 (-4.9A) | 0.29A | 6exiA-6f3mB:52.3 | 6exiA-6f3mB:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6f3m | - (-) |
no annotation | 8 | HIS B 61THR B 63GLN B 65THR B 66HIS B 323LEU B 376GLY B 381PHE B 391 | ADN B 502 ( 4.0A)ADN B 502 (-2.8A) K B 504 ( 3.0A)ADN B 502 (-4.6A) ZN B 505 (-3.2A)ADN B 502 ( 4.8A)ADN B 502 ( 3.7A)ADN B 502 (-4.9A) | 0.98A | 6exiA-6f3mB:52.3 | 6exiA-6f3mB:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6gbn | - (-) |
no annotation | 11 | HIS A 56THR A 58GLN A 60THR A 61ASP A 193ASN A 349LEU A 350GLY A 355HIS A 356MET A 361PHE A 365 | ADN A 501 (-3.9A)ADN A 501 (-2.8A) NA A 503 ( 3.2A)ADN A 501 (-4.6A)ADN A 501 (-2.7A)NAD A 502 (-3.1A)ADN A 501 ( 4.7A)ADN A 501 (-3.8A)ADN A 501 (-3.4A)ADN A 501 (-3.6A)None | 0.20A | 6exiA-6gbnA:57.3 | 6exiA-6gbnA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6gbn | - (-) |
no annotation | 8 | HIS A 56THR A 58GLN A 60THR A 61HIS A 304LEU A 350GLY A 355PHE A 365 | ADN A 501 (-3.9A)ADN A 501 (-2.8A) NA A 503 ( 3.2A)ADN A 501 (-4.6A)ADN A 501 ( 3.6A)ADN A 501 ( 4.7A)ADN A 501 (-3.8A)None | 0.99A | 6exiA-6gbnA:57.3 | 6exiA-6gbnA:undetectable |