SIMILAR PATTERNS OF AMINO ACIDS FOR 6EXI_A_ADNA502

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fwx NITROUS OXIDE
REDUCTASE

(Paracoccus
denitrificans) 		PF13473
(Cupredoxin_1) 		5 THR A 202
HIS A  82
ASN A 273
GLY A 271
HIS A 325
 None
None
CL  A4901 (-3.5A)
CL  A4901 ( 3.7A)
CUZ  A4801 ( 3.3A)
 1.48A 6exiA-1fwxA:
undetectable		 6exiA-1fwxA:
8.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q8f PYRIMIDINE
NUCLEOSIDE HYDROLASE

(Escherichia
coli) 		PF01156
(IU_nuc_hydro) 		5 HIS A 239
THR A 242
HIS A  82
ASN A 166
GLY A 151
 GOL  A3001 ( 3.9A)
None
GOL  A3005 (-3.9A)
GOL  A3001 (-3.3A)
None
 1.45A 6exiA-1q8fA:
7.5		 6exiA-1q8fA:
15.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tve HOMOSERINE
DEHYDROGENASE

(Saccharomyces
cerevisiae) 		PF00742
(Homoserine_dh)
PF03447
(NAD_binding_3) 		5 THR A 225
ASN A 216
LEU A 218
GLY A 217
PHE A 241
 None
 1.37A 6exiA-1tveA:
2.3		 6exiA-1tveA:
17.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v8b ADENOSYLHOMOCYSTEINA
SE

(Plasmodium
falciparum) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		9 HIS A  54
THR A  56
ASP A 234
ASN A 391
LEU A 392
GLY A 397
HIS A 398
MET A 403
PHE A 407
 ADN  A 502 (-4.1A)
ADN  A 502 (-3.0A)
ADN  A 502 (-2.8A)
NAD  A 501 (-3.0A)
ADN  A 502 ( 4.9A)
ADN  A 502 ( 3.7A)
ADN  A 502 ( 3.5A)
ADN  A 502 (-3.6A)
None
 0.33A 6exiA-1v8bA:
59.1		 6exiA-1v8bA:
11.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fyw CONSERVED
HYPOTHETICAL PROTEIN

(Streptococcus
pneumoniae) 		PF01784
(NIF3) 		5 HIS A 225
ASP A 103
HIS A  65
GLY A 185
PHE A 113
 None
 1.48A 6exiA-2fywA:
undetectable		 6exiA-2fywA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g5c PREPHENATE
DEHYDROGENASE

(Aquifex
aeolicus) 		PF02153
(PDH) 		5 THR A 120
LEU A 172
GLY A 145
MET A  96
PHE A  94
 None
 1.45A 6exiA-2g5cA:
8.0		 6exiA-2g5cA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g5c PREPHENATE
DEHYDROGENASE

(Aquifex
aeolicus) 		PF02153
(PDH) 		5 THR A 120
LEU A 172
GLY A 146
MET A  96
PHE A  94
 None
 1.13A 6exiA-2g5cA:
8.0		 6exiA-2g5cA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gj4 GLYCOGEN
PHOSPHORYLASE,
MUSCLE FORM

(Oryctolagus
cuniculus) 		PF00343
(Phosphorylase) 		5 THR A 671
THR A 668
ASN A 284
LEU A 380
HIS A 571
 None
 1.17A 6exiA-2gj4A:
4.9		 6exiA-2gj4A:
7.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jdx PROTEIN
(L-ARGININE:GLYCINE
AMIDINOTRANSFERASE)

(Homo sapiens) 		no annotation 5 ASP A 170
ASN A 361
LEU A 358
GLY A 404
MET A 167
 None
 1.04A 6exiA-2jdxA:
undetectable		 6exiA-2jdxA:
10.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pq6 UDP-GLUCURONOSYL/UDP
-GLUCOSYLTRANSFERASE

(Medicago
truncatula) 		PF00201
(UDPGT) 		5 THR A 305
ASP A 402
ASN A 382
GLY A  20
PHE A 400
 None
 1.34A 6exiA-2pq6A:
4.6		 6exiA-2pq6A:
11.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pq6 UDP-GLUCURONOSYL/UDP
-GLUCOSYLTRANSFERASE

(Medicago
truncatula) 		PF00201
(UDPGT) 		5 THR A 305
THR A 306
ASP A 402
ASN A 382
GLY A  20
 None
 1.48A 6exiA-2pq6A:
4.6		 6exiA-2pq6A:
11.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vmf BETA-MANNOSIDASE

(Bacteroides
thetaiotaomicron) 		PF00703
(Glyco_hydro_2) 		5 HIS A 511
ASP A 529
ASN A 460
GLY A 459
PHE A 508
 EDO  A1872 (-4.6A)
None
None
None
None
 1.36A 6exiA-2vmfA:
undetectable		 6exiA-2vmfA:
7.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w5s PROCESSED GLYCEROL
PHOSPHATE
LIPOTEICHOIC ACID
SYNTHASE

(Staphylococcus
aureus) 		PF00884
(Sulfatase) 		5 HIS A 416
THR A 420
ASP A 388
LEU A 384
GLY A 385
 GP9  A1644 (-4.0A)
None
None
None
None
 1.48A 6exiA-2w5sA:
undetectable		 6exiA-2w5sA:
17.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wab ENDOGLUCANASE E

(Ruminiclostridium
thermocellum) 		PF00657
(Lipase_GDSL) 		5 HIS A 316
THR A 315
GLY A 306
HIS A 310
MET A 263
 None
GOL  A1341 (-3.7A)
None
BGC  A1338 (-4.0A)
BGC  A1337 (-4.5A)
 1.28A 6exiA-2wabA:
5.4		 6exiA-2wabA:
14.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wab ENDOGLUCANASE E

(Ruminiclostridium
thermocellum) 		PF00657
(Lipase_GDSL) 		5 THR A 315
GLN A 299
GLY A 306
HIS A 310
MET A 263
 GOL  A1341 (-3.7A)
None
None
BGC  A1338 (-4.0A)
BGC  A1337 (-4.5A)
 1.36A 6exiA-2wabA:
5.4		 6exiA-2wabA:
14.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xsr CATECHOL 1,2
DIOXYGENASE

(Acinetobacter
radioresistens) 		PF00775
(Dioxygenase_C)
PF04444
(Dioxygenase_N) 		5 ASP A 246
LEU A 207
GLY A 214
HIS A 213
PHE A 250
 None
 1.43A 6exiA-2xsrA:
undetectable		 6exiA-2xsrA:
13.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ayf NITRIC OXIDE
REDUCTASE

(Geobacillus
stearothermophilus) 		PF00115
(COX1) 		5 THR A  99
THR A 217
ASP A 500
GLY A  89
HIS A  90
 None
 1.30A 6exiA-3ayfA:
undetectable		 6exiA-3ayfA:
9.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3azq AMINOPEPTIDASE

(Streptomyces
morookaense) 		PF00326
(Peptidase_S9) 		5 THR A 531
ASP A 445
LEU A 533
GLY A 509
PHE A 449
 None
 1.27A 6exiA-3azqA:
2.7		 6exiA-3azqA:
8.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ce6 ADENOSYLHOMOCYSTEINA
SE

(Mycobacterium
tuberculosis) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		11 HIS A  69
THR A  71
GLN A  73
THR A  74
ASP A 252
ASN A 409
LEU A 410
GLY A 415
HIS A 416
MET A 421
PHE A 425
 ADN  A 500 (-4.0A)
ADN  A 500 (-2.8A)
ADN  A 500 (-3.6A)
ADN  A 500 (-4.5A)
ADN  A 500 (-2.7A)
NAD  A 550 (-3.0A)
ADN  A 500 ( 4.8A)
ADN  A 500 ( 3.6A)
ADN  A 500 ( 3.6A)
ADN  A 500 (-3.7A)
ADN  A 500 (-4.8A)
 0.26A 6exiA-3ce6A:
59.6		 6exiA-3ce6A:
60.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ce6 ADENOSYLHOMOCYSTEINA
SE

(Mycobacterium
tuberculosis) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		8 HIS A  69
THR A  71
GLN A  73
THR A  74
HIS A 363
LEU A 410
GLY A 415
PHE A 425
 ADN  A 500 (-4.0A)
ADN  A 500 (-2.8A)
ADN  A 500 (-3.6A)
ADN  A 500 (-4.5A)
ADN  A 500 ( 3.7A)
ADN  A 500 ( 4.8A)
ADN  A 500 ( 3.6A)
ADN  A 500 (-4.8A)
 1.00A 6exiA-3ce6A:
59.6		 6exiA-3ce6A:
60.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3g1u ADENOSYLHOMOCYSTEINA
SE

(Leishmania
major) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		10 HIS A  52
THR A  54
GLN A  56
THR A  57
ASN A 345
LEU A 346
GLY A 351
HIS A 352
MET A 357
PHE A 361
 ADN  A 438 (-4.0A)
ADN  A 438 (-2.8A)
ADN  A 438 (-3.8A)
ADN  A 438 (-4.6A)
NAD  A 439 (-3.1A)
ADN  A 438 ( 4.8A)
ADN  A 438 ( 3.8A)
ADN  A 438 ( 3.6A)
ADN  A 438 (-3.7A)
None
 0.18A 6exiA-3g1uA:
56.5		 6exiA-3g1uA:
71.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3g1u ADENOSYLHOMOCYSTEINA
SE

(Leishmania
major) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		8 HIS A  52
THR A  54
GLN A  56
THR A  57
HIS A 300
LEU A 346
GLY A 351
PHE A 361
 ADN  A 438 (-4.0A)
ADN  A 438 (-2.8A)
ADN  A 438 (-3.8A)
ADN  A 438 (-4.6A)
ADN  A 438 ( 4.0A)
ADN  A 438 ( 4.8A)
ADN  A 438 ( 3.8A)
None
 1.01A 6exiA-3g1uA:
56.5		 6exiA-3g1uA:
71.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ggg PREPHENATE
DEHYDROGENASE

(Aquifex
aeolicus) 		no annotation 5 THR D 120
LEU D 172
GLY D 145
MET D  96
PHE D  94
 None
 1.37A 6exiA-3gggD:
3.6		 6exiA-3gggD:
12.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ggg PREPHENATE
DEHYDROGENASE

(Aquifex
aeolicus) 		no annotation 5 THR D 120
LEU D 172
GLY D 146
MET D  96
PHE D  94
 None
 1.04A 6exiA-3gggD:
3.6		 6exiA-3gggD:
12.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3glq ADENOSYLHOMOCYSTEINA
SE

(Burkholderia
pseudomallei) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		11 HIS A  62
THR A  64
GLN A  66
THR A  67
ASP A 233
ASN A 387
LEU A 388
GLY A 393
HIS A 394
MET A 399
PHE A 403
 RAB  A 602 (-3.8A)
RAB  A 602 (-2.7A)
RAB  A 602 (-3.9A)
RAB  A 602 (-4.5A)
RAB  A 602 (-2.5A)
NAD  A 601 (-3.0A)
RAB  A 602 ( 4.7A)
RAB  A 602 ( 3.8A)
NAD  A 601 ( 3.6A)
RAB  A 602 (-3.6A)
None
 0.27A 6exiA-3glqA:
60.2		 6exiA-3glqA:
61.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3glq ADENOSYLHOMOCYSTEINA
SE

(Burkholderia
pseudomallei) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		8 HIS A  62
THR A  64
GLN A  66
THR A  67
HIS A 344
LEU A 388
GLY A 393
PHE A 403
 RAB  A 602 (-3.8A)
RAB  A 602 (-2.7A)
RAB  A 602 (-3.9A)
RAB  A 602 (-4.5A)
RAB  A 602 ( 3.5A)
RAB  A 602 ( 4.7A)
RAB  A 602 ( 3.8A)
None
 1.00A 6exiA-3glqA:
60.2		 6exiA-3glqA:
61.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h9u ADENOSYLHOMOCYSTEINA
SE

(Trypanosoma
brucei) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		11 HIS A  52
THR A  54
GLN A  56
THR A  57
ASP A 189
ASN A 345
LEU A 346
GLY A 351
HIS A 352
MET A 357
PHE A 361
 ADN  A 439 ( 4.7A)
ADN  A 439 (-2.7A)
ADN  A 439 (-3.6A)
ADN  A 439 (-4.7A)
NAD  A 438 ( 4.4A)
NAD  A 438 (-2.9A)
ADN  A 439 ( 4.7A)
ADN  A 439 (-3.5A)
ADN  A 439 ( 3.3A)
ADN  A 439 ( 3.7A)
None
 0.29A 6exiA-3h9uA:
56.3		 6exiA-3h9uA:
13.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h9u ADENOSYLHOMOCYSTEINA
SE

(Trypanosoma
brucei) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		7 HIS A  52
THR A  54
GLN A  56
THR A  57
HIS A 300
LEU A 346
PHE A 361
 ADN  A 439 ( 4.7A)
ADN  A 439 (-2.7A)
ADN  A 439 (-3.6A)
ADN  A 439 (-4.7A)
None
ADN  A 439 ( 4.7A)
None
 1.05A 6exiA-3h9uA:
56.3		 6exiA-3h9uA:
13.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k5h PHOSPHORIBOSYL-AMINO
IMIDAZOLE
CARBOXYLASE

(Aspergillus
clavatus) 		PF01262
(AlaDh_PNT_C)
PF02222
(ATP-grasp) 		5 HIS A 273
THR A 209
GLY A 276
HIS A 277
MET A 313
 None
 1.46A 6exiA-3k5hA:
undetectable		 6exiA-3k5hA:
13.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n58 ADENOSYLHOMOCYSTEINA
SE

(Brucella
abortus) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		11 HIS A  55
THR A  57
GLN A  59
THR A  60
ASP A 226
ASN A 380
LEU A 381
GLY A 386
HIS A 387
MET A 392
PHE A 396
 ADN  A 500 (-4.0A)
ADN  A 500 (-2.8A)
K  A   2 ( 3.3A)
ADN  A 500 (-4.6A)
ADN  A 500 ( 2.6A)
NAD  A 550 (-3.0A)
ADN  A 500 ( 4.8A)
ADN  A 500 (-3.7A)
ADN  A 500 (-3.4A)
ADN  A 500 (-3.7A)
None
 0.23A 6exiA-3n58A:
61.1		 6exiA-3n58A:
14.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n58 ADENOSYLHOMOCYSTEINA
SE

(Brucella
abortus) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		8 HIS A  55
THR A  57
GLN A  59
THR A  60
HIS A 337
LEU A 381
GLY A 386
PHE A 396
 ADN  A 500 (-4.0A)
ADN  A 500 (-2.8A)
K  A   2 ( 3.3A)
ADN  A 500 (-4.6A)
ADN  A 500 ( 3.6A)
ADN  A 500 ( 4.8A)
ADN  A 500 (-3.7A)
None
 1.01A 6exiA-3n58A:
61.1		 6exiA-3n58A:
14.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3one ADENOSYLHOMOCYSTEINA
SE

(Lupinus luteus) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		11 HIS A  62
THR A  64
GLN A  66
THR A  67
ASP A 239
ASN A 397
LEU A 398
GLY A 403
HIS A 404
MET A 409
PHE A 413
 ADE  A 506 (-4.6A)
ADE  A 506 (-2.8A)
ADE  A 506 (-3.8A)
ADE  A 506 (-4.5A)
NAD  A 501 ( 4.5A)
NAD  A 501 (-3.0A)
ADE  A 506 ( 4.7A)
ADE  A 506 ( 3.6A)
ADE  A 506 (-3.4A)
ADE  A 506 (-3.8A)
ADE  A 506 (-4.9A)
 0.28A 6exiA-3oneA:
56.4		 6exiA-3oneA:
64.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3one ADENOSYLHOMOCYSTEINA
SE

(Lupinus luteus) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		8 HIS A  62
THR A  64
GLN A  66
THR A  67
HIS A 350
LEU A 398
GLY A 403
PHE A 413
 ADE  A 506 (-4.6A)
ADE  A 506 (-2.8A)
ADE  A 506 (-3.8A)
ADE  A 506 (-4.5A)
None
ADE  A 506 ( 4.7A)
ADE  A 506 ( 3.6A)
ADE  A 506 (-4.9A)
 1.03A 6exiA-3oneA:
56.4		 6exiA-3oneA:
64.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t3o METAL DEPENDENT
HYDROLASE

(Thermus
thermophilus) 		PF07521
(RMMBL)
PF12706
(Lactamase_B_2) 		5 GLN A 404
ASP A 204
ASN A  24
GLY A  17
HIS A 398
 None
None
ZN  A 600 ( 4.7A)
None
ZN  A 600 (-3.6A)
 1.46A 6exiA-3t3oA:
undetectable		 6exiA-3t3oA:
11.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c25 L-FUCULOSE PHOSPHATE
ALDOLASE

(Streptococcus
pneumoniae) 		PF00596
(Aldolase_II) 		5 THR A  96
THR A  21
HIS A  78
GLY A 156
HIS A 155
 None
None
None
None
ZN  A 301 ( 3.2A)
 1.39A 6exiA-4c25A:
undetectable		 6exiA-4c25A:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fxq PUTATIVE
ADP-RIBOSYLTRANSFERA
SE CERTHRAX

(Bacillus cereus) 		PF03496
(ADPrib_exo_Tox)
PF07737
(ATLF) 		5 THR A 439
THR A 379
ASP A 295
GLY A 437
HIS A 383
 None
 1.32A 6exiA-4fxqA:
undetectable		 6exiA-4fxqA:
11.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hyn CHEC, INHIBITOR OF
MCP METHYLATION /
FLIN FUSION PROTEIN

(Thermotoga
maritima) 		PF04509
(CheC) 		5 GLN A 202
HIS A  57
ASN A  38
GLY A  37
PHE A 200
 None
 1.31A 6exiA-4hynA:
undetectable		 6exiA-4hynA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l7z HPCH/HPAI ALDOLASE

(Chloroflexus
aurantiacus) 		PF03328
(HpcH_HpaI) 		5 GLN A 220
LEU A 223
GLY A 199
HIS A 200
PHE A 218
 None
 1.33A 6exiA-4l7zA:
undetectable		 6exiA-4l7zA:
15.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4lvc S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(SAHASE)

(Bradyrhizobium
elkanii) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		11 HIS A  58
THR A  60
GLN A  62
THR A  63
ASP A 231
ASN A 385
LEU A 386
GLY A 391
HIS A 392
MET A 397
PHE A 401
 ADN  A 501 (-4.0A)
ADN  A 501 (-2.8A)
NH4  A 502 ( 3.1A)
ADN  A 501 (-4.5A)
ADN  A 501 (-3.1A)
NAD  A 503 (-3.1A)
ADN  A 501 ( 4.7A)
ADN  A 501 (-3.6A)
ADN  A 501 (-3.5A)
ADN  A 501 (-3.7A)
ADN  A 501 (-4.8A)
 0.28A 6exiA-4lvcA:
68.4		 6exiA-4lvcA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4lvc S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(SAHASE)

(Bradyrhizobium
elkanii) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		8 HIS A  58
THR A  60
GLN A  62
THR A  63
HIS A 342
LEU A 386
GLY A 391
PHE A 401
 ADN  A 501 (-4.0A)
ADN  A 501 (-2.8A)
NH4  A 502 ( 3.1A)
ADN  A 501 (-4.5A)
ADN  A 501 ( 3.7A)
ADN  A 501 ( 4.7A)
ADN  A 501 (-3.6A)
ADN  A 501 (-4.8A)
 1.02A 6exiA-4lvcA:
68.4		 6exiA-4lvcA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mo9 PERIPLASMIC BINDING
PROTEIN

(Veillonella
parvula) 		PF01497
(Peripla_BP_2) 		5 ASP A  77
LEU A 314
GLY A 313
MET A  78
PHE A  82
 None
 1.37A 6exiA-4mo9A:
3.6		 6exiA-4mo9A:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oe5 DELTA-1-PYRROLINE-5-
CARBOXYLATE
DEHYDROGENASE,
MITOCHONDRIAL

(Homo sapiens) 		PF00171
(Aldedh) 		5 THR A 285
ASN A 319
LEU A 478
GLY A 317
PHE A 212
 None
 1.15A 6exiA-4oe5A:
undetectable		 6exiA-4oe5A:
9.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p08 COCAINE ESTERASE

(Rhodococcus sp.
MB1) 		PF02129
(Peptidase_S15)
PF08530
(PepX_C) 		5 THR A 510
THR A 442
ASP A 343
HIS A 518
LEU A 476
 None
 1.40A 6exiA-4p08A:
3.6		 6exiA-4p08A:
10.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4s2t PROTEIN APP-1

(Caenorhabditis
elegans) 		PF00557
(Peptidase_M24)
PF01321
(Creatinase_N)
PF16188
(Peptidase_M24_C)
PF16189
(Creatinase_N_2) 		5 HIS P 483
ASP P 424
HIS P 392
GLY P 486
HIS P 487
 None
ZN  P 701 (-2.4A)
None
None
ZN  P 702 ( 3.7A)
 1.49A 6exiA-4s2tP:
undetectable		 6exiA-4s2tP:
9.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v15 D-THREONINE ALDOLASE

(Achromobacter
xylosoxidans) 		PF01168
(Ala_racemase_N)
PF14031
(D-ser_dehydrat) 		5 HIS A 347
THR A 300
THR A 351
HIS A 193
GLY A 304
 MN  A1382 (-3.4A)
None
None
None
None
 1.45A 6exiA-4v15A:
undetectable		 6exiA-4v15A:
15.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xwt DR2417

(Deinococcus
radiodurans) 		PF00753
(Lactamase_B)
PF07521
(RMMBL) 		5 GLN A 409
ASP A 209
ASN A  33
GLY A  26
HIS A 403
 None
None
ZN  A 602 ( 4.5A)
None
ZN  A 602 (-3.2A)
 1.39A 6exiA-4xwtA:
undetectable		 6exiA-4xwtA:
10.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ycz FUSION PROTEIN OF
SEC13 AND NUP145C

(Thermothelomyces
thermophila) 		PF00400
(WD40)
PF12110
(Nup96) 		5 ASP A 141
HIS A1670
GLY A1744
HIS A1743
PHE A 139
 None
 1.41A 6exiA-4yczA:
undetectable		 6exiA-4yczA:
7.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h83 HETEROYOHIMBINE
SYNTHASE HYS

(Catharanthus
roseus) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 HIS A 127
ASP A  54
GLY A  99
HIS A  73
PHE A  69
 None
None
None
ZN  A 901 (-3.1A)
None
 1.33A 6exiA-5h83A:
6.6		 6exiA-5h83A:
10.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i3a TYROSINASE

(Bacillus
megaterium) 		PF00264
(Tyrosinase) 		5 GLN A 193
HIS A 231
ASN A 205
GLY A 196
PHE A 190
 None
ZN  A 302 (-3.1A)
HQE  A 303 (-3.4A)
None
None
 1.19A 6exiA-5i3aA:
undetectable		 6exiA-5i3aA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i51 TRANSKETOLASE

(Scheffersomyces
stipitis) 		PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		5 ASN A  64
LEU A  62
GLY A  65
HIS A  66
PHE A  90
 None
None
None
TPP  A 701 ( 3.5A)
None
 1.26A 6exiA-5i51A:
undetectable		 6exiA-5i51A:
9.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jkn PROTEIN FAM63A

(Homo sapiens) 		PF04424
(MINDY_DUB) 		5 THR A 295
THR A 290
LEU A 241
GLY A 239
HIS A 238
 None
 1.42A 6exiA-5jknA:
undetectable		 6exiA-5jknA:
15.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uq6 TARTRATE-RESISTANT
ACID PHOSPHATASE
TYPE 5

(Sus scrofa) 		PF00149
(Metallophos) 		5 HIS A 195
THR A 198
ASP A  14
ASN A  91
HIS A 186
 PO4  A 404 (-3.8A)
None
FE  A 402 ( 3.1A)
PO4  A 404 ( 2.6A)
FE  A 403 ( 3.4A)
 1.26A 6exiA-5uq6A:
undetectable		 6exiA-5uq6A:
15.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uq6 TARTRATE-RESISTANT
ACID PHOSPHATASE
TYPE 5

(Sus scrofa) 		PF00149
(Metallophos) 		5 HIS A 195
THR A 198
HIS A 223
ASN A  91
HIS A 186
 PO4  A 404 (-3.8A)
None
FE  A 402 (-3.4A)
PO4  A 404 ( 2.6A)
FE  A 403 ( 3.4A)
 1.38A 6exiA-5uq6A:
undetectable		 6exiA-5uq6A:
15.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5utu ADENOSYLHOMOCYSTEINA
SE

(Cryptosporidium
parvum) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		10 HIS A  53
THR A  55
THR A  58
ASP A 245
ASN A 403
LEU A 404
GLY A 409
HIS A 410
MET A 415
PHE A 419
 SAH  A 502 (-4.0A)
SAH  A 502 (-2.7A)
SAH  A 502 (-4.2A)
SAH  A 502 (-2.8A)
NAD  A 501 (-2.9A)
SAH  A 502 ( 4.7A)
SAH  A 502 ( 3.7A)
SAH  A 502 ( 3.5A)
SAH  A 502 (-3.6A)
SAH  A 502 (-4.8A)
 0.32A 6exiA-5utuA:
53.7		 6exiA-5utuA:
9.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v96 S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE

(Naegleria
fowleri) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		10 HIS A  59
THR A  61
THR A  64
ASP A 231
ASN A 388
LEU A 389
GLY A 394
HIS A 395
MET A 400
PHE A 404
 ADN  A 502 ( 3.9A)
ADN  A 502 (-2.9A)
ADN  A 502 (-4.4A)
ADN  A 502 (-2.8A)
NAD  A 501 (-3.1A)
ADN  A 502 ( 4.7A)
ADN  A 502 (-3.7A)
ADN  A 502 ( 3.4A)
ADN  A 502 (-3.8A)
ADN  A 502 (-4.9A)
 0.26A 6exiA-5v96A:
61.0		 6exiA-5v96A:
13.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vrb TRANSKETOLASE

(Neisseria
gonorrhoeae) 		PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		5 ASN A  61
LEU A  59
GLY A  62
HIS A  63
PHE A  87
 OCS  A 154 ( 4.3A)
None
None
CA  A 704 ( 4.9A)
None
 1.26A 6exiA-5vrbA:
undetectable		 6exiA-5vrbA:
9.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w4b ADENOSYLHOMOCYSTEINA
SE

(Homo sapiens) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		5 ASN A 346
LEU A 347
GLY A 352
HIS A 353
MET A 358
 NAD  A 501 (-3.1A)
9W4  A 502 (-4.1A)
9W4  A 502 ( 3.9A)
NAD  A 501 (-4.5A)
9W4  A 502 (-3.6A)
 0.48A 6exiA-5w4bA:
48.4		 6exiA-5w4bA:
12.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w4b ADENOSYLHOMOCYSTEINA
SE

(Homo sapiens) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		5 ASP A 190
ASN A 346
LEU A 347
GLY A 352
HIS A 353
 NAD  A 501 (-4.1A)
NAD  A 501 (-3.1A)
9W4  A 502 (-4.1A)
9W4  A 502 ( 3.9A)
NAD  A 501 (-4.5A)
 0.44A 6exiA-5w4bA:
48.4		 6exiA-5w4bA:
12.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w4b ADENOSYLHOMOCYSTEINA
SE

(Homo sapiens) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		5 HIS A  55
THR A  57
THR A  60
ASP A 190
PHE A 362
 9W4  A 502 (-3.7A)
9W4  A 502 (-2.9A)
None
NAD  A 501 (-4.1A)
None
 0.60A 6exiA-5w4bA:
48.4		 6exiA-5w4bA:
12.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w4b ADENOSYLHOMOCYSTEINA
SE

(Homo sapiens) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		5 HIS A  55
THR A  57
THR A  60
MET A 358
PHE A 362
 9W4  A 502 (-3.7A)
9W4  A 502 (-2.9A)
None
9W4  A 502 (-3.6A)
None
 0.23A 6exiA-5w4bA:
48.4		 6exiA-5w4bA:
12.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w4b ADENOSYLHOMOCYSTEINA
SE

(Homo sapiens) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		5 THR A  57
ASN A 346
LEU A 347
GLY A 352
HIS A 353
 9W4  A 502 (-2.9A)
NAD  A 501 (-3.1A)
9W4  A 502 (-4.1A)
9W4  A 502 ( 3.9A)
NAD  A 501 (-4.5A)
 0.79A 6exiA-5w4bA:
48.4		 6exiA-5w4bA:
12.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yvs ALCOHOL
DEHYDROGENASE

(candidate
divison MSBL1
archaeon
SCGC-AAA259E19) 		no annotation 5 THR A 147
ASP A 102
HIS A 288
ASN A 264
GLY A 261
 None
NDP  A 502 (-2.6A)
NDP  A 502 ( 3.0A)
NDP  A 502 ( 4.9A)
None
 1.43A 6exiA-5yvsA:
undetectable		 6exiA-5yvsA:
16.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ywp JEV E PROTEIN

(Japanese
encephalitis
virus) 		no annotation 5 THR A 317
THR A 321
ASP A  42
GLY A   5
PHE A  11
 None
 1.29A 6exiA-5ywpA:
undetectable		 6exiA-5ywpA:
25.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6aph ADENOSYLHOMOCYSTEINA
SE

(Elizabethkingia
anophelis) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		11 HIS A  58
THR A  60
GLN A  62
THR A  63
ASP A 195
ASN A 351
LEU A 352
GLY A 357
HIS A 358
MET A 363
PHE A 367
 ADN  A 501 (-3.9A)
ADN  A 501 (-2.8A)
ADN  A 501 (-3.8A)
ADN  A 501 (-4.5A)
ADN  A 501 (-2.7A)
NAD  A 500 (-3.1A)
ADN  A 501 ( 4.8A)
ADN  A 501 (-3.6A)
ADN  A 501 ( 3.5A)
ADN  A 501 (-3.7A)
None
 0.24A 6exiA-6aphA:
56.9		 6exiA-6aphA:
69.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6aph ADENOSYLHOMOCYSTEINA
SE

(Elizabethkingia
anophelis) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		8 HIS A  58
THR A  60
GLN A  62
THR A  63
HIS A 306
LEU A 352
GLY A 357
PHE A 367
 ADN  A 501 (-3.9A)
ADN  A 501 (-2.8A)
ADN  A 501 (-3.8A)
ADN  A 501 (-4.5A)
ADN  A 501 ( 3.7A)
ADN  A 501 ( 4.8A)
ADN  A 501 (-3.6A)
None
 0.99A 6exiA-6aphA:
56.9		 6exiA-6aphA:
69.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f3m -

(-) 		no annotation 11 HIS B  61
THR B  63
GLN B  65
THR B  66
ASP B 198
ASN B 375
LEU B 376
GLY B 381
HIS B 382
MET B 387
PHE B 391
 ADN  B 502 ( 4.0A)
ADN  B 502 (-2.8A)
K  B 504 ( 3.0A)
ADN  B 502 (-4.6A)
ADN  B 502 (-2.7A)
NAD  B 501 (-3.0A)
ADN  B 502 ( 4.8A)
ADN  B 502 ( 3.7A)
ADN  B 502 (-3.4A)
ADN  B 502 (-3.7A)
ADN  B 502 (-4.9A)
 0.29A 6exiA-6f3mB:
52.3		 6exiA-6f3mB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f3m -

(-) 		no annotation 8 HIS B  61
THR B  63
GLN B  65
THR B  66
HIS B 323
LEU B 376
GLY B 381
PHE B 391
 ADN  B 502 ( 4.0A)
ADN  B 502 (-2.8A)
K  B 504 ( 3.0A)
ADN  B 502 (-4.6A)
ZN  B 505 (-3.2A)
ADN  B 502 ( 4.8A)
ADN  B 502 ( 3.7A)
ADN  B 502 (-4.9A)
 0.98A 6exiA-6f3mB:
52.3		 6exiA-6f3mB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gbn -

(-) 		no annotation 11 HIS A  56
THR A  58
GLN A  60
THR A  61
ASP A 193
ASN A 349
LEU A 350
GLY A 355
HIS A 356
MET A 361
PHE A 365
 ADN  A 501 (-3.9A)
ADN  A 501 (-2.8A)
NA  A 503 ( 3.2A)
ADN  A 501 (-4.6A)
ADN  A 501 (-2.7A)
NAD  A 502 (-3.1A)
ADN  A 501 ( 4.7A)
ADN  A 501 (-3.8A)
ADN  A 501 (-3.4A)
ADN  A 501 (-3.6A)
None
 0.20A 6exiA-6gbnA:
57.3		 6exiA-6gbnA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gbn -

(-) 		no annotation 8 HIS A  56
THR A  58
GLN A  60
THR A  61
HIS A 304
LEU A 350
GLY A 355
PHE A 365
 ADN  A 501 (-3.9A)
ADN  A 501 (-2.8A)
NA  A 503 ( 3.2A)
ADN  A 501 (-4.6A)
ADN  A 501 ( 3.6A)
ADN  A 501 ( 4.7A)
ADN  A 501 (-3.8A)
None
 0.99A 6exiA-6gbnA:
57.3		 6exiA-6gbnA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b6r PROTEIN
(N5-CARBOXYAMINOIMID
AZOLE RIBONUCLEOTIDE
SYNTHETASE)

(Escherichia
coli) 		PF02222
(ATP-grasp) 		3 LEU A 335
ASN A 252
LEU A 328
 None
 0.69A 6exiA-1b6rA:
1.4		 6exiA-1b6rA:
12.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b7e PROTEIN (TRANSPOSASE
INHIBITOR PROTEIN
FROM TN5)

(Escherichia
coli) 		PF01609
(DDE_Tnp_1)
PF02281
(Dimer_Tnp_Tn5) 		3 LEU A 301
ASN A 276
LEU A 201
 None
 0.62A 6exiA-1b7eA:
undetectable		 6exiA-1b7eA:
11.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b9l PROTEIN (EPIMERASE)

(Escherichia
coli) 		PF02152
(FolB) 		3 LEU A  13
ASN A  70
LEU A  79
 None
 0.57A 6exiA-1b9lA:
undetectable		 6exiA-1b9lA:
25.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bhg BETA-GLUCURONIDASE

(Homo sapiens) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N) 		3 LEU A 565
ASN A 349
LEU A 622
 None
 0.60A 6exiA-1bhgA:
0.7		 6exiA-1bhgA:
11.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bhg BETA-GLUCURONIDASE

(Homo sapiens) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N) 		3 LEU A 573
ASN A 349
LEU A 622
 None
 0.65A 6exiA-1bhgA:
0.7		 6exiA-1bhgA:
11.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bqg D-GLUCARATE
DEHYDRATASE

(Pseudomonas
putida) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		3 LEU A 130
ASN A  91
LEU A  78
 None
 0.70A 6exiA-1bqgA:
undetectable		 6exiA-1bqgA:
11.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cjy PROTEIN (CYTOSOLIC
PHOSPHOLIPASE A2)

(Homo sapiens) 		PF00168
(C2)
PF01735
(PLA2_B) 		3 LEU A 570
ASN A 704
LEU A 212
 None
 0.60A 6exiA-1cjyA:
undetectable		 6exiA-1cjyA:
7.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cqk CH3 DOMAIN OF MAK33
ANTIBODY

(Mus musculus) 		PF07654
(C1-set) 		3 LEU A  23
ASN A  82
LEU A  26
 None
 0.68A 6exiA-1cqkA:
undetectable		 6exiA-1cqkA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dce PROTEIN (RAB
GERANYLGERANYLTRANSF
ERASE ALPHA SUBUNIT)

(Rattus
norvegicus) 		PF01239
(PPTA)
PF07711
(RabGGT_insert) 		3 LEU A 462
ASN A 473
LEU A 478
 None
 0.70A 6exiA-1dceA:
undetectable		 6exiA-1dceA:
10.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f59 IMPORTIN BETA-1

(Homo sapiens) 		PF03810
(IBN_N)
PF13513
(HEAT_EZ) 		3 LEU A  65
ASN A  93
LEU A  44
 None
 0.70A 6exiA-1f59A:
undetectable		 6exiA-1f59A:
12.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f8f BENZYL ALCOHOL
DEHYDROGENASE

(Acinetobacter
calcoaceticus) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		3 LEU A   4
ASN A 124
LEU A 150
 None
 0.68A 6exiA-1f8fA:
9.8		 6exiA-1f8fA:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fhf SEED COAT PEROXIDASE

(Glycine max) 		PF00141
(peroxidase) 		3 LEU A 183
ASN A 219
LEU A 243
 None
 0.70A 6exiA-1fhfA:
undetectable		 6exiA-1fhfA:
12.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fn9 OUTER-CAPSID PROTEIN
SIGMA 3

(Reovirus sp.) 		PF00979
(Reovirus_cap) 		3 LEU A 131
ASN A 139
LEU A 265
 None
 0.68A 6exiA-1fn9A:
undetectable		 6exiA-1fn9A:
13.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fs2 SKP2

(Homo sapiens) 		PF12937
(F-box-like) 		3 LEU A 260
ASN A 301
LEU A 270
 None
 0.68A 6exiA-1fs2A:
undetectable		 6exiA-1fs2A:
15.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fs2 SKP2

(Homo sapiens) 		PF12937
(F-box-like) 		3 LEU A 317
ASN A 274
LEU A 264
 None
 0.43A 6exiA-1fs2A:
undetectable		 6exiA-1fs2A:
15.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gnx BETA-GLUCOSIDASE

(Streptomyces
sp.) 		PF00232
(Glyco_hydro_1) 		3 LEU A 377
ASN A 307
LEU A 367
 None
 0.64A 6exiA-1gnxA:
undetectable		 6exiA-1gnxA:
12.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h4l CELL DIVISION
PROTEIN KINASE 5

(Homo sapiens) 		PF00069
(Pkinase) 		3 LEU A 195
ASN A  62
LEU A 127
 None
 0.66A 6exiA-1h4lA:
undetectable		 6exiA-1h4lA:
11.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hfs STROMELYSIN-1

(Homo sapiens) 		PF00413
(Peptidase_M10) 		3 LEU A 245
ASN A 175
LEU A  97
 None
 0.62A 6exiA-1hfsA:
undetectable		 6exiA-1hfsA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hlg LIPASE, GASTRIC

(Homo sapiens) 		PF00561
(Abhydrolase_1) 		3 LEU A 240
ASN A 250
LEU A 256
 None
 0.61A 6exiA-1hlgA:
5.3		 6exiA-1hlgA:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i5p PESTICIDIAL CRYSTAL
PROTEIN CRY2AA

(Bacillus
thuringiensis) 		PF03944
(Endotoxin_C)
PF03945
(Endotoxin_N)
PF09131
(Endotoxin_mid) 		3 LEU A  62
ASN A 274
LEU A 250
 None
 0.55A 6exiA-1i5pA:
undetectable		 6exiA-1i5pA:
8.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iko EPHRIN-B2

(Mus musculus) 		PF00812
(Ephrin) 		3 LEU P  61
ASN P  39
LEU P 102
 None
NAG  P   1 (-1.8A)
None
 0.45A 6exiA-1ikoP:
undetectable		 6exiA-1ikoP:
15.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iv8 MALTOOLIGOSYL
TREHALOSE SYNTHASE

(Sulfolobus
acidocaldarius) 		PF00128
(Alpha-amylase)
PF09196
(DUF1953) 		3 LEU A 689
ASN A 711
LEU A 664
 None
 0.69A 6exiA-1iv8A:
undetectable		 6exiA-1iv8A:
7.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jch COLICIN E3 IMMUNITY
PROTEIN

(Escherichia
coli) 		PF03513
(Cloacin_immun) 		3 LEU B  58
ASN B  42
LEU B   2
 None
 0.71A 6exiA-1jchB:
undetectable		 6exiA-1jchB:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jjo NEUROSERPIN

(Mus musculus) 		PF00079
(Serpin) 		3 LEU C 131
ASN C 181
LEU C 184
 None
 0.59A 6exiA-1jjoC:
undetectable		 6exiA-1jjoC:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jl5 OUTER PROTEIN YOPM

(Yersinia pestis) 		PF12468
(TTSSLRR) 		3 LEU A1096
ASN A1122
LEU A1126
 None
 0.60A 6exiA-1jl5A:
undetectable		 6exiA-1jl5A:
9.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jl5 OUTER PROTEIN YOPM

(Yersinia pestis) 		PF12468
(TTSSLRR) 		3 LEU A1332
ASN A1303
LEU A1295
 None
 0.62A 6exiA-1jl5A:
undetectable		 6exiA-1jl5A:
9.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jmu PROTEIN MU-1

(Reovirus sp.) 		PF05993
(Reovirus_M2) 		3 LEU B 219
ASN B 202
LEU B 665
 BOG  B 709 ( 4.4A)
None
None
 0.64A 6exiA-1jmuB:
undetectable		 6exiA-1jmuB:
8.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jqo PHOSPHOENOLPYRUVATE
CARBOXYLASE

(Zea mays) 		PF00311
(PEPcase) 		3 LEU A 611
ASN A 808
LEU A 870
 None
 0.64A 6exiA-1jqoA:
undetectable		 6exiA-1jqoA:
6.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jsw L-ASPARTATE
AMMONIA-LYASE

(Escherichia
coli) 		PF00206
(Lyase_1)
PF10415
(FumaraseC_C) 		3 LEU A 211
ASN A 337
LEU A 379
 None
 0.55A 6exiA-1jswA:
undetectable		 6exiA-1jswA:
12.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jtd BETA-LACTAMASE
INHIBITOR PROTEIN II

(Streptomyces
exfoliatus) 		PF13540
(RCC1_2) 		3 LEU B 258
ASN B 246
LEU B 233
 None
 0.68A 6exiA-1jtdB:
undetectable		 6exiA-1jtdB:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kgs DNA BINDING RESPONSE
REGULATOR D

(Thermotoga
maritima) 		PF00072
(Response_reg)
PF00486
(Trans_reg_C) 		3 LEU A  52
ASN A  74
LEU A 117
 None
 0.62A 6exiA-1kgsA:
6.1		 6exiA-1kgsA:
15.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1krq FERRITIN

(Campylobacter
jejuni) 		PF00210
(Ferritin) 		3 LEU A  57
ASN A 118
LEU A   2
 None
 0.64A 6exiA-1krqA:
undetectable		 6exiA-1krqA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mz5 SIALIDASE

(Trypanosoma
rangeli) 		PF13385
(Laminin_G_3)
PF13859
(BNR_3) 		3 LEU A 501
ASN A 605
LEU A 485
 None
 0.70A 6exiA-1mz5A:
undetectable		 6exiA-1mz5A:
8.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nlu SEDOLISIN

(Pseudomonas sp.) 		no annotation 3 LEU A 356
ASN A 368
LEU A 308
 None
 0.69A 6exiA-1nluA:
undetectable		 6exiA-1nluA:
12.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nq4 OXYTETRACYCLINE
POLYKETIDE SYNTHASE
ACYL CARRIER PROTEIN

(Streptomyces
rimosus) 		PF00550
(PP-binding) 		3 LEU A  37
ASN A  46
LEU A  73
 None
 0.65A 6exiA-1nq4A:
undetectable		 6exiA-1nq4A:
26.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1po0 IRON(III) DICITRATE
TRANSPORT PROTEIN
FECA PRECURSOR

(Escherichia
coli) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		3 LEU A 179
ASN A 213
LEU A 124
 None
 0.66A 6exiA-1po0A:
undetectable		 6exiA-1po0A:
8.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q50 GLUCOSE-6-PHOSPHATE
ISOMERASE

(Leishmania
mexicana) 		PF00342
(PGI) 		3 LEU A  51
ASN A 380
LEU A 118
 None
 0.67A 6exiA-1q50A:
undetectable		 6exiA-1q50A:
10.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q5a EP-CADHERIN

(Mus musculus) 		PF00028
(Cadherin) 		3 LEU A 354
ASN A 373
LEU A 379
 None
 0.64A 6exiA-1q5aA:
undetectable		 6exiA-1q5aA:
6.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q5a EP-CADHERIN

(Mus musculus) 		PF00028
(Cadherin) 		3 LEU A 354
ASN A 373
LEU A 428
 None
 0.48A 6exiA-1q5aA:
undetectable		 6exiA-1q5aA:
6.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q5a EP-CADHERIN

(Mus musculus) 		PF00028
(Cadherin) 		3 LEU A 354
ASN A 391
LEU A 428
 None
 0.00A 6exiA-1q5aA:
undetectable		 6exiA-1q5aA:
6.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q8i DNA POLYMERASE II

(Escherichia
coli) 		PF00136
(DNA_pol_B)
PF03104
(DNA_pol_B_exo1) 		3 LEU A  32
ASN A 137
LEU A 140
 None
 0.53A 6exiA-1q8iA:
undetectable		 6exiA-1q8iA:
8.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qo4 PEROXIDASE

(Arabidopsis
thaliana) 		PF00141
(peroxidase) 		3 LEU A 183
ASN A 219
LEU A 243
 None
 0.70A 6exiA-1qo4A:
undetectable		 6exiA-1qo4A:
14.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r20 ULTRASPIRACLE
PROTEIN

(Heliothis
virescens) 		PF00104
(Hormone_recep) 		3 LEU A 208
ASN A 376
LEU A 273
 None
 0.66A 6exiA-1r20A:
undetectable		 6exiA-1r20A:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rjc CAMELID HEAVY CHAIN
ANTIBODY

(Camelus
dromedarius) 		PF07686
(V-set) 		3 LEU A   4
ASN A  32
LEU A  72
 None
 0.56A 6exiA-1rjcA:
undetectable		 6exiA-1rjcA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rpt PROSTATIC ACID
PHOSPHATASE

(Rattus
norvegicus) 		PF00328
(His_Phos_2) 		3 LEU A 312
ASN A 233
LEU A 264
 None
 0.54A 6exiA-1rptA:
undetectable		 6exiA-1rptA:
15.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ryy ALPHA-AMINO ACID
ESTER HYDROLASE

(Acetobacter
pasteurianus) 		PF02129
(Peptidase_S15)
PF08530
(PepX_C) 		3 LEU A 446
ASN A 603
LEU A 547
 None
 0.59A 6exiA-1ryyA:
3.3		 6exiA-1ryyA:
7.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1slm STROMELYSIN-1

(Homo sapiens) 		PF00413
(Peptidase_M10)
PF01471
(PG_binding_1) 		3 LEU A 245
ASN A 175
LEU A  97
 None
 0.68A 6exiA-1slmA:
undetectable		 6exiA-1slmA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sus CAFFEOYL-COA
O-METHYLTRANSFERASE

(Medicago sativa) 		PF01596
(Methyltransf_3) 		3 LEU A  94
ASN A  82
LEU A  75
 None
 0.59A 6exiA-1susA:
3.1		 6exiA-1susA:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1szs 4-AMINOBUTYRATE
AMINOTRANSFERASE

(Escherichia
coli) 		PF00202
(Aminotran_3) 		3 LEU A 276
ASN A  94
LEU A 312
 None
 0.67A 6exiA-1szsA:
undetectable		 6exiA-1szsA:
11.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t3i PROBABLE CYSTEINE
DESULFURASE

(Synechocystis
sp.) 		PF00266
(Aminotran_5) 		3 LEU A 342
ASN A 346
LEU A 321
 None
 0.70A 6exiA-1t3iA:
2.1		 6exiA-1t3iA:
10.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t90 PROBABLE
METHYLMALONATE-SEMIA
LDEHYDE
DEHYDROGENASE

(Bacillus
subtilis) 		PF00171
(Aldedh) 		3 LEU A  72
ASN A 463
LEU A 121
 None
 0.63A 6exiA-1t90A:
4.6		 6exiA-1t90A:
13.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tll NITRIC-OXIDE
SYNTHASE, BRAIN

(Rattus
norvegicus) 		PF00175
(NAD_binding_1)
PF00258
(Flavodoxin_1)
PF00667
(FAD_binding_1) 		3 LEU A1359
ASN A1388
LEU A1339
 None
 0.70A 6exiA-1tllA:
4.3		 6exiA-1tllA:
8.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tp9 PEROXIREDOXIN

(Populus
trichocarpa) 		PF08534
(Redoxin) 		3 LEU A  10
ASN A 143
LEU A 114
 None
 0.65A 6exiA-1tp9A:
undetectable		 6exiA-1tp9A:
24.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tv8 MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
A

(Staphylococcus
aureus) 		PF04055
(Radical_SAM)
PF06463
(Mob_synth_C)
PF13394
(Fer4_14) 		3 LEU A  83
ASN A 124
LEU A 108
 None
 0.57A 6exiA-1tv8A:
undetectable		 6exiA-1tv8A:
12.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1txo PUTATIVE BACTERIAL
ENZYME

(Mycobacterium
tuberculosis) 		PF13672
(PP2C_2) 		3 LEU A 175
ASN A  81
LEU A  57
 None
 0.69A 6exiA-1txoA:
undetectable		 6exiA-1txoA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u4q SPECTRIN ALPHA
CHAIN, BRAIN

(Gallus gallus) 		PF00435
(Spectrin) 		3 LEU A1850
ASN A1839
LEU A1771
 None
 0.65A 6exiA-1u4qA:
undetectable		 6exiA-1u4qA:
14.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u6g TIP120 PROTEIN

(Homo sapiens) 		PF08623
(TIP120) 		3 LEU C 655
ASN C 680
LEU C 685
 None
 0.66A 6exiA-1u6gC:
undetectable		 6exiA-1u6gC:
6.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u6g TIP120 PROTEIN

(Homo sapiens) 		PF08623
(TIP120) 		3 LEU C 896
ASN C 887
LEU C 880
 None
 0.71A 6exiA-1u6gC:
undetectable		 6exiA-1u6gC:
6.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ucs ANTIFREEZE PEPTIDE
RD1

(Lycodichthys
dearborni) 		PF08666
(SAF) 		3 LEU A  10
ASN A  46
LEU A  17
 None
 0.71A 6exiA-1ucsA:
undetectable		 6exiA-1ucsA:
24.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uus STAT PROTEIN

(Dictyostelium
discoideum) 		PF00017
(SH2)
PF09267
(Dict-STAT-coil) 		3 LEU A 343
ASN A 274
LEU A 288
 None
 0.60A 6exiA-1uusA:
undetectable		 6exiA-1uusA:
9.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uww ENDOGLUCANASE

(Bacillus akibai) 		PF03424
(CBM_17_28) 		3 LEU A  53
ASN A 165
LEU A  18
 None
 0.68A 6exiA-1uwwA:
undetectable		 6exiA-1uwwA:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v8y ADP-RIBOSE
PYROPHOSPHATASE

(Thermus
thermophilus) 		PF00293
(NUDIX) 		3 LEU A  76
ASN A 117
LEU A  83
 None
 0.68A 6exiA-1v8yA:
undetectable		 6exiA-1v8yA:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vbg PYRUVATE,ORTHOPHOSPH
ATE DIKINASE

(Zea mays) 		PF00391
(PEP-utilizers)
PF01326
(PPDK_N)
PF02896
(PEP-utilizers_C) 		3 LEU A  66
ASN A 241
LEU A 207
 None
 0.56A 6exiA-1vbgA:
undetectable		 6exiA-1vbgA:
6.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vi4 REGULATOR OF
RIBONUCLEASE
ACTIVITY A PROTEIN 1

(Vibrio cholerae) 		PF03737
(RraA-like) 		3 LEU A 113
ASN A 136
LEU A  20
 None
 0.57A 6exiA-1vi4A:
undetectable		 6exiA-1vi4A:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vlv ORNITHINE
CARBAMOYLTRANSFERASE

(Thermotoga
maritima) 		PF00185
(OTCace)
PF02729
(OTCace_N) 		3 LEU A 172
ASN A 149
LEU A 153
 None
 0.62A 6exiA-1vlvA:
8.7		 6exiA-1vlvA:
13.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w55 ISPD/ISPF
BIFUNCTIONAL ENZYME

(Campylobacter
jejuni) 		PF01128
(IspD)
PF02542
(YgbB) 		3 LEU A 249
ASN A 302
LEU A 329
 None
 0.59A 6exiA-1w55A:
undetectable		 6exiA-1w55A:
13.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xec DECORIN

(Bos taurus) 		PF01462
(LRRNT)
PF13855
(LRR_8) 		3 LEU A 199
ASN A 238
LEU A 245
 None
 0.66A 6exiA-1xecA:
undetectable		 6exiA-1xecA:
13.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xhb POLYPEPTIDE
N-ACETYLGALACTOSAMIN
YLTRANSFERASE 1

(Mus musculus) 		PF00535
(Glycos_transf_2)
PF00652
(Ricin_B_lectin) 		3 LEU A 483
ASN A 436
LEU A 550
 None
 0.66A 6exiA-1xhbA:
undetectable		 6exiA-1xhbA:
8.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xl8 PEROXISOMAL
CARNITINE
O-OCTANOYLTRANSFERAS
E

(Mus musculus) 		PF00755
(Carn_acyltransf) 		3 LEU A 133
ASN A 312
LEU A 162
 None
 0.55A 6exiA-1xl8A:
undetectable		 6exiA-1xl8A:
11.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xpo RHO TRANSCRIPTION
TERMINATION FACTOR

(Escherichia
coli) 		PF00006
(ATP-synt_ab)
PF07497
(Rho_RNA_bind)
PF07498
(Rho_N) 		3 LEU A  39
ASN A   8
LEU A  14
 None
 0.62A 6exiA-1xpoA:
undetectable		 6exiA-1xpoA:
10.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xtj PROBABLE
ATP-DEPENDENT RNA
HELICASE P47

(Homo sapiens) 		PF00270
(DEAD)
PF00271
(Helicase_C) 		3 LEU A 285
ASN A 361
LEU A 278
 None
 0.67A 6exiA-1xtjA:
2.4		 6exiA-1xtjA:
10.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xxi DNA POLYMERASE III
SUBUNIT GAMMA

(Escherichia
coli) 		PF12169
(DNA_pol3_gamma3)
PF13177
(DNA_pol3_delta2) 		3 LEU B 354
ASN B 269
LEU B 252
 None
 0.67A 6exiA-1xxiB:
undetectable		 6exiA-1xxiB:
15.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yfj DNA ADENINE
METHYLASE

(Escherichia
virus T4) 		PF02086
(MethyltransfD12) 		3 LEU A 175
ASN A 195
LEU A 209
 None
 0.70A 6exiA-1yfjA:
3.7		 6exiA-1yfjA:
14.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ywf PHOSPHOTYROSINE
PROTEIN PHOSPHATASE
PTPB

(Mycobacterium
tuberculosis) 		PF13350
(Y_phosphatase3) 		3 LEU A  47
ASN A  11
LEU A  33
 None
 0.64A 6exiA-1ywfA:
undetectable		 6exiA-1ywfA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ac5 MAP
KINASE-INTERACTING
SERINE/THREONINE
KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		3 LEU A 288
ASN A 141
LEU A 206
 None
 0.66A 6exiA-2ac5A:
undetectable		 6exiA-2ac5A:
13.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2amc PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN
PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN

(Thermus
thermophilus;
Thermus
thermophilus) 		PF01409
(tRNA-synt_2d)
PF01409
(tRNA-synt_2d)
PF01588
(tRNA_bind)
PF03147
(FDX-ACB)
PF03483
(B3_4)
PF03484
(B5) 		3 LEU B 544
ASN A 133
LEU A 161
 None
 0.68A 6exiA-2amcB:
undetectable		 6exiA-2amcB:
9.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ass S-PHASE
KINASE-ASSOCIATED
PROTEIN 2

(Homo sapiens) 		PF12937
(F-box-like) 		3 LEU B2248
ASN B2289
LEU B2258
 None
 0.70A 6exiA-2assB:
undetectable		 6exiA-2assB:
12.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ass S-PHASE
KINASE-ASSOCIATED
PROTEIN 2

(Homo sapiens) 		PF12937
(F-box-like) 		3 LEU B2305
ASN B2262
LEU B2252
 None
 0.59A 6exiA-2assB:
undetectable		 6exiA-2assB:
12.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bdw HYPOTHETICAL PROTEIN
K11E8.1D

(Caenorhabditis
elegans) 		PF00069
(Pkinase) 		3 LEU A 206
ASN A  71
LEU A 136
 None
 0.69A 6exiA-2bdwA:
undetectable		 6exiA-2bdwA:
12.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bgh VINORINE SYNTHASE

(Rauvolfia
serpentina) 		PF02458
(Transferase) 		3 LEU A 332
ASN A 277
LEU A 298
 None
 0.64A 6exiA-2bghA:
undetectable		 6exiA-2bghA:
10.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c6x CITRATE SYNTHASE 1

(Bacillus
subtilis) 		PF00285
(Citrate_synt) 		3 LEU A 323
ASN A 150
LEU A 168
 None
 0.59A 6exiA-2c6xA:
undetectable		 6exiA-2c6xA:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cfo GLUTAMYL-TRNA
SYNTHETASE

(Synechococcus
elongatus) 		PF00749
(tRNA-synt_1c) 		3 LEU A 292
ASN A 320
LEU A 289
 None
 0.69A 6exiA-2cfoA:
undetectable		 6exiA-2cfoA:
12.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d07 G/T
MISMATCH-SPECIFIC
THYMINE DNA
GLYCOSYLASE

(Homo sapiens) 		PF03167
(UDG) 		3 LEU A 132
ASN A 191
LEU A 219
 None
 0.66A 6exiA-2d07A:
undetectable		 6exiA-2d07A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dla 397AA LONG
HYPOTHETICAL PROTEIN

(Pyrococcus
horikoshii) 		PF04104
(DNA_primase_lrg) 		3 LEU A 169
ASN A 180
LEU A  90
 None
 0.68A 6exiA-2dlaA:
undetectable		 6exiA-2dlaA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2es3 THROMBOSPONDIN-1

(Homo sapiens) 		PF02210
(Laminin_G_2) 		3 LEU A 130
ASN A 158
LEU A 112
 None
 0.70A 6exiA-2es3A:
undetectable		 6exiA-2es3A:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g9b CALBINDIN

(Rattus
norvegicus) 		PF13405
(EF-hand_6)
PF13499
(EF-hand_7) 		3 LEU A  54
ASN A  38
LEU A  78
 None
 0.68A 6exiA-2g9bA:
undetectable		 6exiA-2g9bA:
13.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g9w CONSERVED
HYPOTHETICAL PROTEIN

(Mycobacterium
tuberculosis) 		PF03965
(Penicillinase_R) 		3 LEU A  18
ASN A  56
LEU A   4
 None
 0.59A 6exiA-2g9wA:
undetectable		 6exiA-2g9wA:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gie TYPE II RESTRICTION
ENZYME HINCII

(Haemophilus
influenzae) 		PF09226
(Endonuc-HincII) 		3 LEU A 169
ASN A  48
LEU A 117
 None
 0.65A 6exiA-2gieA:
undetectable		 6exiA-2gieA:
14.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gu0 NONSTRUCTURAL
PROTEIN 2

(Rotavirus C) 		PF02509
(Rota_NS35) 		3 LEU A  69
ASN A 141
LEU A  83
 None
 0.71A 6exiA-2gu0A:
undetectable		 6exiA-2gu0A:
14.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gzs IROE PROTEIN

(Escherichia
coli) 		PF00756
(Esterase) 		3 LEU A 103
ASN A 292
LEU A 300
 None
 0.68A 6exiA-2gzsA:
2.8		 6exiA-2gzsA:
16.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h00 METHYLTRANSFERASE 10
DOMAIN CONTAINING
PROTEIN

(Homo sapiens) 		PF05971
(Methyltransf_10) 		3 LEU A  23
ASN A  47
LEU A  87
 None
 0.68A 6exiA-2h00A:
6.7		 6exiA-2h00A:
15.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h00 METHYLTRANSFERASE 10
DOMAIN CONTAINING
PROTEIN

(Homo sapiens) 		PF05971
(Methyltransf_10) 		3 LEU A  23
ASN A  88
LEU A 114
 None
 0.56A 6exiA-2h00A:
6.7		 6exiA-2h00A:
15.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hpa PROTEIN (ACID
PHOSPHATASE)

(Homo sapiens) 		PF00328
(His_Phos_2) 		3 LEU A1312
ASN A1233
LEU A1264
 None
 0.65A 6exiA-2hpaA:
undetectable		 6exiA-2hpaA:
15.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2huj LIN2004 PROTEIN

(Listeria
innocua) 		PF08807
(DUF1798) 		3 LEU A  67
ASN A  78
LEU A  52
 None
 0.71A 6exiA-2hujA:
undetectable		 6exiA-2hujA:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i05 DNA REPLICATION
TERMINUS
SITE-BINDING PROTEIN

(Escherichia
coli) 		PF05472
(Ter) 		3 LEU A  28
ASN A 264
LEU A  34
 None
 0.66A 6exiA-2i05A:
undetectable		 6exiA-2i05A:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ilr FANCONI ANEMIA GROUP
E PROTEIN

(Homo sapiens) 		PF11510
(FA_FANCE) 		3 LEU A 492
ASN A 503
LEU A 512
 None
 0.54A 6exiA-2ilrA:
undetectable		 6exiA-2ilrA:
14.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jam CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE 1G

(Homo sapiens) 		PF00069
(Pkinase) 		3 LEU A 213
ASN A  80
LEU A 145
 None
 0.67A 6exiA-2jamA:
undetectable		 6exiA-2jamA:
13.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jeo URIDINE-CYTIDINE
KINASE 1

(Homo sapiens) 		PF00485
(PRK) 		3 LEU A 231
ASN A  50
LEU A 136
 None
 0.68A 6exiA-2jeoA:
undetectable		 6exiA-2jeoA:
14.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ko6 UNCHARACTERIZED
PROTEIN YIHD

(Shigella
flexneri) 		PF06288
(DUF1040) 		3 LEU A  26
ASN A   7
LEU A  13
 None
 0.59A 6exiA-2ko6A:
undetectable		 6exiA-2ko6A:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2l3f UNCHARACTERIZED
PROTEIN

(Methanosarcina
acetivorans) 		PF03167
(UDG) 		3 LEU A 134
ASN A  68
LEU A  72
 None
 0.68A 6exiA-2l3fA:
undetectable		 6exiA-2l3fA:
19.38