SIMILAR PATTERNS OF AMINO ACIDS FOR 6EW0_I_TA1I501_2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bih HEMOLIN

(Hyalophora
cecropia) 		PF07679
(I-set)
PF13927
(Ig_3) 		4 LEU A 163
THR A 166
ARG A 271
ARG A 266
 None
 1.29A 6ew0I-1bihA:
undetectable		 6ew0I-1bihA:
12.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e08 [FE]-HYDROGENASE
(LARGE SUBUNIT)

(Desulfovibrio
desulfuricans) 		PF02906
(Fe_hyd_lg_C)
PF13187
(Fer4_9) 		4 LEU A 258
THR A 228
PRO A 108
ARG A 282
 None
None
CMO  A   9 ( 3.8A)
None
 1.37A 6ew0I-1e08A:
0.0		 6ew0I-1e08A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eu1 DIMETHYL SULFOXIDE
REDUCTASE

(Rhodobacter
sphaeroides) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding) 		4 LEU A 670
THR A 225
PRO A 240
ARG A 239
 None
MGD  A1002 ( 4.6A)
MGD  A1002 (-4.0A)
None
 1.20A 6ew0I-1eu1A:
1.8		 6ew0I-1eu1A:
7.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lgf P450 MONOOXYGENASE

(Amycolatopsis
orientalis) 		PF00067
(p450) 		4 LEU A 235
THR A 386
PRO A 148
ARG A 126
 None
 1.27A 6ew0I-1lgfA:
0.0		 6ew0I-1lgfA:
14.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rhc F420-DEPENDENT
ALCOHOL
DEHYDROGENASE

(Methanoculleus
thermophilus) 		PF00296
(Bac_luciferase) 		4 LEU A 139
THR A 154
PRO A  76
ARG A  79
 None
None
None
F42  A 351 ( 4.9A)
 1.21A 6ew0I-1rhcA:
0.6		 6ew0I-1rhcA:
13.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sjp 60 KDA CHAPERONIN 2

(Mycobacterium
tuberculosis) 		PF00118
(Cpn60_TCP1) 		4 LEU A 369
THR A 293
PRO A 276
ARG A 282
 None
 1.26A 6ew0I-1sjpA:
0.0		 6ew0I-1sjpA:
11.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sng COG4826: SERINE
PROTEASE INHIBITOR

(Thermobifida
fusca) 		PF00079
(Serpin) 		4 LEU A   8
THR A 212
ARG A 245
ARG A 206
 None
 1.25A 6ew0I-1sngA:
0.2		 6ew0I-1sngA:
12.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t8h YLMD PROTEIN
SEQUENCE HOMOLOGUE

(Geobacillus
stearothermophilus) 		PF02578
(Cu-oxidase_4) 		4 LEU A 117
THR A  28
ARG A  60
ARG A  52
 None
 1.26A 6ew0I-1t8hA:
0.0		 6ew0I-1t8hA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u7k GAG POLYPROTEIN

(Murine leukemia
virus) 		PF02093
(Gag_p30) 		4 LEU A  40
THR A  61
ARG A 119
PRO A  50
 None
 1.30A 6ew0I-1u7kA:
0.0		 6ew0I-1u7kA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zj9 PROBABLE
FERREDOXIN-DEPENDENT
NITRITE REDUCTASE
NIRA

(Mycobacterium
tuberculosis) 		PF01077
(NIR_SIR)
PF03460
(NIR_SIR_ferr) 		4 LEU A 441
THR A 457
PRO A 407
ARG A 406
 None
 1.18A 6ew0I-1zj9A:
undetectable		 6ew0I-1zj9A:
8.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2blb DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE

(Plasmodium
vivax) 		PF00186
(DHFR_1) 		4 LEU A 187
ARG A 180
PRO A 207
ARG A  34
 None
 1.40A 6ew0I-2blbA:
undetectable		 6ew0I-2blbA:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gdf LECTIN

(Dioclea
violacea) 		PF00139
(Lectin_legB) 		4 LEU A   9
THR A 105
PRO A 206
ARG A 204
 None
 1.37A 6ew0I-2gdfA:
undetectable		 6ew0I-2gdfA:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gqt UDP-N-ACETYLENOLPYRU
VYLGLUCOSAMINE
REDUCTASE

(Thermus
caldophilus) 		PF01565
(FAD_binding_4)
PF02873
(MurB_C) 		4 LEU A  82
THR A  14
ARG A 187
ARG A 151
 None
None
FAD  A 601 (-2.7A)
None
 1.31A 6ew0I-2gqtA:
undetectable		 6ew0I-2gqtA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2l5a HISTONE H3-LIKE
CENTROMERIC PROTEIN
CSE4, PROTEIN SCM3,
HISTONE H4

(Saccharomyces
cerevisiae) 		PF00125
(Histone)
PF10384
(Scm3)
PF15511
(CENP-T_C) 		4 LEU A  89
THR A 219
PRO A  80
ARG A  81
 None
 1.33A 6ew0I-2l5aA:
undetectable		 6ew0I-2l5aA:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2og7 ASPARAGINE OXYGENASE

(Streptomyces
coelicolor) 		PF02668
(TauD) 		4 LEU A 259
THR A 153
ARG A 239
ARG A 209
 None
 1.27A 6ew0I-2og7A:
undetectable		 6ew0I-2og7A:
11.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p6p GLYCOSYL TRANSFERASE

(Streptomyces
fradiae) 		PF06722
(DUF1205) 		4 LEU A 122
THR A  53
PRO A 108
ARG A 107
 None
 1.39A 6ew0I-2p6pA:
1.3		 6ew0I-2p6pA:
12.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2paj PUTATIVE
CYTOSINE/GUANINE
DEAMINASE

(unidentified) 		PF01979
(Amidohydro_1) 		4 LEU A 126
THR A 391
PRO A 441
ARG A 423
 None
 1.31A 6ew0I-2pajA:
undetectable		 6ew0I-2pajA:
9.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r0l HEPATOCYTE GROWTH
FACTOR ACTIVATOR

(Homo sapiens) 		PF00089
(Trypsin)
no annotation 		4 LEU A 123
THR A  49
ARG B 395
ARG B 390
 None
 1.07A 6ew0I-2r0lA:
undetectable		 6ew0I-2r0lA:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r3a HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV39H2

(Homo sapiens) 		PF00856
(SET)
PF05033
(Pre-SET) 		4 LEU A 194
THR A 175
PRO A 241
ARG A 242
 None
 1.37A 6ew0I-2r3aA:
undetectable		 6ew0I-2r3aA:
15.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r7d RIBONUCLEASE II
FAMILY PROTEIN

(Deinococcus
radiodurans) 		PF00773
(RNB) 		4 LEU A  43
THR A  12
ARG A  60
PRO A  56
 None
 1.29A 6ew0I-2r7dA:
undetectable		 6ew0I-2r7dA:
10.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uv8 FATTY ACID SYNTHASE
SUBUNIT BETA (FAS1)

(Saccharomyces
cerevisiae) 		PF00698
(Acyl_transf_1)
PF01575
(MaoC_dehydratas)
PF08354
(DUF1729)
PF13452
(MaoC_dehydrat_N)
PF16073
(SAT) 		4 LEU G 471
THR G 462
PRO G 458
ARG G 264
 None
 1.33A 6ew0I-2uv8G:
undetectable		 6ew0I-2uv8G:
3.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vsu P-HYDROXYCINNAMOYL
COA HYDRATASE/LYASE

(Pseudomonas
fluorescens) 		PF00378
(ECH_1) 		4 LEU C 101
THR C  47
ARG C  39
ARG C  26
 None
 1.22A 6ew0I-2vsuC:
undetectable		 6ew0I-2vsuC:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w9y FATTY ACID/RETINOL
BINDING PROTEIN
PROTEIN 7, ISOFORM
A, CONFIRMED BY
TRANSCRIPT EVIDENCE

(Caenorhabditis
elegans) 		PF05823
(Gp-FAR-1) 		4 LEU A  64
THR A  95
ARG A  74
PRO A  15
 None
 1.27A 6ew0I-2w9yA:
undetectable		 6ew0I-2w9yA:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ynm LIGHT-INDEPENDENT
PROTOCHLOROPHYLLIDE
REDUCTASE SUBUNIT B
LIGHT-INDEPENDENT
PROTOCHLOROPHYLLIDE
REDUCTASE SUBUNIT N

(Prochlorococcus
marinus) 		PF00148
(Oxidored_nitro)
PF08369
(PCP_red) 		4 THR D   7
ARG C  90
PRO C  58
ARG C  59
 None
 1.34A 6ew0I-2ynmD:
undetectable		 6ew0I-2ynmD:
10.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bb8 CDP-4-KETO-6-DEOXY-D
-GLUCOSE-3-DEHYDRASE

(Yersinia
pseudotuberculosis) 		PF01041
(DegT_DnrJ_EryC1) 		4 LEU A 237
THR A  98
ARG A 245
ARG A 249
 None
 1.23A 6ew0I-3bb8A:
undetectable		 6ew0I-3bb8A:
11.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f5f MALTOSE-BINDING
PERIPLASMIC PROTEIN,
HEPARAN SULFATE
2-O-SULFOTRANSFERASE
1

(Escherichia
coli;
Gallus gallus) 		PF03567
(Sulfotransfer_2)
PF13416
(SBP_bac_8) 		4 LEU A1264
THR A1090
ARG A 354
ARG A1101
 None
 1.33A 6ew0I-3f5fA:
undetectable		 6ew0I-3f5fA:
7.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f5f MALTOSE-BINDING
PERIPLASMIC PROTEIN,
HEPARAN SULFATE
2-O-SULFOTRANSFERASE
1

(Escherichia
coli;
Gallus gallus) 		PF03567
(Sulfotransfer_2)
PF13416
(SBP_bac_8) 		4 LEU A1264
THR A1090
ARG A1270
PRO A1136
 None
 1.38A 6ew0I-3f5fA:
undetectable		 6ew0I-3f5fA:
7.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3flu DIHYDRODIPICOLINATE
SYNTHASE

(Neisseria
meningitidis) 		PF00701
(DHDPS) 		4 LEU A 173
THR A 147
PRO A 136
ARG A 138
 None
None
None
SO4  A 293 (-4.0A)
 1.13A 6ew0I-3fluA:
undetectable		 6ew0I-3fluA:
16.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g20 TYPE II SECRETION
PROTEIN

(Escherichia
coli) 		PF08334
(T2SSG) 		4 LEU A 100
THR A  46
PRO A  77
ARG A  78
 None
 1.36A 6ew0I-3g20A:
undetectable		 6ew0I-3g20A:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gc2 O-SUCCINYLBENZOATE
SYNTHASE

(Salmonella
enterica) 		PF13378
(MR_MLE_C) 		4 LEU A 149
THR A 111
ARG A 159
ARG A 105
 None
None
EPE  A 402 (-3.8A)
None
 1.15A 6ew0I-3gc2A:
undetectable		 6ew0I-3gc2A:
15.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3glv LIPOPOLYSACCHARIDE
CORE BIOSYNTHESIS
PROTEIN

(Thermoplasma
volcanium) 		PF01467
(CTP_transf_like) 		4 LEU A  56
THR A   7
PRO A  48
ARG A  42
 None
 1.34A 6ew0I-3glvA:
undetectable		 6ew0I-3glvA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gsz RNA-DIRECTED RNA
POLYMERASE

(Hepacivirus C) 		PF00998
(RdRP_3) 		4 LEU A 256
THR A 287
ARG A 234
ARG A 278
 None
 1.33A 6ew0I-3gszA:
undetectable		 6ew0I-3gszA:
7.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h0g DNA-DIRECTED RNA
POLYMERASES I, II,
AND III SUBUNIT
RPABC5

(Schizosaccharomyces
pombe) 		PF01194
(RNA_pol_N) 		4 LEU J  35
THR J  51
ARG J  42
ARG J   6
 None
 1.32A 6ew0I-3h0gJ:
undetectable		 6ew0I-3h0gJ:
27.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h5j 3-ISOPROPYLMALATE
DEHYDRATASE SMALL
SUBUNIT

(Mycobacterium
tuberculosis) 		PF00694
(Aconitase_C) 		4 LEU A  42
THR A  21
ARG A  32
ARG A  35
 None
None
EDO  A1307 (-3.8A)
None
 1.18A 6ew0I-3h5jA:
undetectable		 6ew0I-3h5jA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hrd NICOTINATE
DEHYDROGENASE LARGE
MOLYBDOPTERIN
SUBUNIT
NICOTINATE
DEHYDROGENASE MEDIUM
MOLYBDOPTERIN
SUBUNIT

(Eubacterium
barkeri) 		PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2) 		4 LEU B  91
THR B  18
PRO B 290
ARG A 351
 None
NIO  B5661 (-3.9A)
None
MCN  B 921 ( 4.0A)
 1.09A 6ew0I-3hrdB:
undetectable		 6ew0I-3hrdB:
14.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3htz ALANYL-TRNA
SYNTHETASE

(Aquifex
aeolicus) 		PF01411
(tRNA-synt_2c) 		4 LEU A  68
THR A 277
ARG A 301
ARG A 267
 None
 1.00A 6ew0I-3htzA:
undetectable		 6ew0I-3htzA:
14.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j3i CAPSID PROTEIN

(Penicillium
chrysogenum
virus) 		no annotation 4 LEU A 692
THR A 602
PRO A 597
ARG A 374
 None
 1.28A 6ew0I-3j3iA:
undetectable		 6ew0I-3j3iA:
5.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jb9 PRE-MRNA-SPLICING
FACTOR SPP42

(Schizosaccharomyces
pombe) 		PF08082
(PRO8NT)
PF08083
(PROCN)
PF10596
(U6-snRNA_bdg)
PF10597
(U5_2-snRNA_bdg)
PF10598
(RRM_4)
PF12134
(PRP8_domainIV) 		4 LEU A1294
THR A1257
PRO A 972
ARG A1461
 None
 1.33A 6ew0I-3jb9A:
undetectable		 6ew0I-3jb9A:
2.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l77 SHORT-CHAIN ALCOHOL
DEHYDROGENASE

(Thermococcus
sibiricus) 		PF00106
(adh_short) 		4 LEU A  89
THR A   7
PRO A 178
ARG A 177
 None
None
NJP  A 501 (-4.7A)
PG4  A 251 (-3.3A)
 1.20A 6ew0I-3l77A:
undetectable		 6ew0I-3l77A:
15.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lop SUBSTRATE BINDING
PERIPLASMIC PROTEIN

(Ralstonia
solanacearum) 		PF13458
(Peripla_BP_6) 		4 LEU A 119
THR A 109
ARG A 339
PRO A 104
 None
 1.01A 6ew0I-3lopA:
undetectable		 6ew0I-3lopA:
12.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mml ALLOPHANATE
HYDROLASE SUBUNIT 1
ALLOPHANATE
HYDROLASE SUBUNIT 2

(Mycolicibacterium
smegmatis) 		PF02626
(CT_A_B)
PF02682
(CT_C_D) 		4 LEU A 227
THR A 255
PRO B 150
ARG B 147
 None
 1.30A 6ew0I-3mmlA:
undetectable		 6ew0I-3mmlA:
15.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mzs CHOLESTEROL
SIDE-CHAIN CLEAVAGE
ENZYME

(Bos taurus) 		PF00067
(p450) 		4 LEU A 300
THR A 434
PRO A 398
ARG A 347
 None
 1.28A 6ew0I-3mzsA:
undetectable		 6ew0I-3mzsA:
12.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mzs CHOLESTEROL
SIDE-CHAIN CLEAVAGE
ENZYME

(Bos taurus) 		PF00067
(p450) 		4 LEU A 300
THR A 434
PRO A 398
ARG A 400
 None
 0.95A 6ew0I-3mzsA:
undetectable		 6ew0I-3mzsA:
12.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n3e ALPHA A CRYSTALLIN

(Danio rerio) 		PF00011
(HSP20) 		4 LEU A 142
THR A 158
ARG A 163
PRO A  83
 None
 1.33A 6ew0I-3n3eA:
undetectable		 6ew0I-3n3eA:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3na0 CHOLESTEROL
SIDE-CHAIN CLEAVAGE
ENZYME,
MITOCHONDRIAL

(Homo sapiens) 		PF00067
(p450) 		4 LEU A 339
THR A 473
PRO A 437
ARG A 439
 None
 0.98A 6ew0I-3na0A:
undetectable		 6ew0I-3na0A:
11.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pmq DECAHEME CYTOCHROME
C MTRF

(Shewanella
oneidensis) 		no annotation 4 LEU A 434
THR A 345
PRO A 389
ARG A 367
 None
 1.36A 6ew0I-3pmqA:
undetectable		 6ew0I-3pmqA:
6.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tfj GCVT-LIKE
AMINOMETHYLTRANSFERA
SE PROTEIN

(Candidatus
Pelagibacter
ubique) 		PF01571
(GCV_T)
PF08669
(GCV_T_C) 		4 LEU A  36
THR A  27
PRO A 234
ARG A 239
 None
 1.27A 6ew0I-3tfjA:
undetectable		 6ew0I-3tfjA:
12.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ubo ADENOSINE KINASE

(Sinorhizobium
meliloti) 		PF00294
(PfkB) 		4 LEU A 222
THR A 186
ARG A 216
ARG A 261
 None
 1.37A 6ew0I-3uboA:
undetectable		 6ew0I-3uboA:
15.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v4p INTEGRIN ALPHA-4

(Homo sapiens) 		PF01839
(FG-GAP)
PF08441
(Integrin_alpha2) 		4 LEU A 177
THR A 199
PRO A 149
ARG A 146
 None
NAG  A 606 ( 4.4A)
None
None
 1.36A 6ew0I-3v4pA:
undetectable		 6ew0I-3v4pA:
9.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vsj 2-AMINO-5-CHLOROPHEN
OL 1,6-DIOXYGENASE
ALPHA SUBUNIT
2-AMINO-5-CHLOROPHEN
OL 1,6-DIOXYGENASE
BETA SUBUNIT

(Comamonas
testosteroni) 		PF02900
(LigB) 		4 LEU A  54
THR A 121
ARG A 108
ARG B  91
 None
 1.27A 6ew0I-3vsjA:
undetectable		 6ew0I-3vsjA:
15.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wnp CYCLOISOMALTOOLIGOSA
CCHARIDE
GLUCANOTRANSFERASE

(Bacillus
circulans) 		PF13199
(Glyco_hydro_66)
PF16990
(CBM_35) 		4 LEU A  80
THR A  49
PRO A 113
ARG A 118
 None
None
SO4  A 804 (-4.0A)
None
 1.29A 6ew0I-3wnpA:
undetectable		 6ew0I-3wnpA:
8.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bqi ALPHA-GLUCAN
PHOSPHORYLASE 2,
CYTOSOLIC

(Arabidopsis
thaliana) 		PF00343
(Phosphorylase) 		4 LEU A 309
THR A 345
ARG A 400
ARG A 411
 None
None
MLR  A 951 (-2.9A)
MLR  A 951 (-4.1A)
 1.01A 6ew0I-4bqiA:
undetectable		 6ew0I-4bqiA:
7.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hdo KREV INTERACTION
TRAPPED PROTEIN 1

(Homo sapiens) 		PF00373
(FERM_M) 		4 LEU A 514
THR A 457
ARG A 509
ARG A 536
 None
 1.34A 6ew0I-4hdoA:
undetectable		 6ew0I-4hdoA:
13.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hjc ENVELOPE
GLYCOPROTEIN

(Rift Valley
fever
phlebovirus) 		PF07245
(Phlebovirus_G2) 		4 LEU A 839
ARG A 933
PRO A 924
ARG A 925
 None
 1.27A 6ew0I-4hjcA:
undetectable		 6ew0I-4hjcA:
11.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4il1 CALMODULIN,
CALCINEURIN SUBUNIT
B TYPE 1,
SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2B
CATALYTIC SUBUNIT
ALPHA ISOFORM

(Rattus
norvegicus) 		PF00149
(Metallophos)
PF13499
(EF-hand_7) 		4 LEU A 466
THR A 476
PRO A 374
ARG A 375
 None
 1.08A 6ew0I-4il1A:
undetectable		 6ew0I-4il1A:
7.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mjk CRISPR PROTEIN

(Archaeoglobus
fulgidus) 		PF09704
(Cas_Cas5d) 		4 LEU A 132
THR A  34
PRO A 181
ARG A 229
 None
 1.18A 6ew0I-4mjkA:
undetectable		 6ew0I-4mjkA:
14.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mtp RNA DEPENDENT RNA
POLYMERASE

(Japanese
encephalitis
virus) 		PF00972
(Flavi_NS5) 		4 LEU A 640
THR A 379
PRO A 368
ARG A 546
 LEU  A 640 ( 0.5A)
THR  A 379 ( 0.8A)
PRO  A 368 ( 1.1A)
ARG  A 546 ( 0.6A)
 1.38A 6ew0I-4mtpA:
undetectable		 6ew0I-4mtpA:
7.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o5p UNCHARACTERIZED
PROTEIN

(Pseudomonas
aeruginosa) 		PF09994
(DUF2235) 		4 LEU A 684
THR A 608
ARG A 242
ARG A 305
 None
 1.20A 6ew0I-4o5pA:
undetectable		 6ew0I-4o5pA:
5.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ora SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2B
CATALYTIC SUBUNIT
BETA ISOFORM

(Homo sapiens) 		PF00149
(Metallophos) 		4 LEU A 142
THR A 152
PRO A  50
ARG A  51
 None
 1.38A 6ew0I-4oraA:
undetectable		 6ew0I-4oraA:
9.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4orb SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2B
CATALYTIC SUBUNIT
ALPHA ISOFORM

(Mus musculus) 		PF00149
(Metallophos) 		4 LEU A 133
THR A 143
PRO A  41
ARG A  42
 None
 1.41A 6ew0I-4orbA:
undetectable		 6ew0I-4orbA:
11.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p69 ISOCITRATE
DEHYDROGENASE
KINASE/PHOSPHATASE

(Escherichia
coli) 		PF06315
(AceK) 		4 LEU A 153
THR A 181
ARG A 171
ARG A 568
 None
 1.09A 6ew0I-4p69A:
undetectable		 6ew0I-4p69A:
9.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pq9 BETA-1,3-GLUCANASE

(Mycobacterium
marinum) 		PF00722
(Glyco_hydro_16) 		4 LEU A 135
THR A 159
ARG A 140
PRO A 217
 None
EDO  A 304 ( 3.5A)
None
None
 1.16A 6ew0I-4pq9A:
undetectable		 6ew0I-4pq9A:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pts GLUTATHIONE
S-TRANSFERASE

(Gordonia
bronchialis) 		PF13409
(GST_N_2)
PF13410
(GST_C_2) 		4 LEU A 269
THR A 226
ARG A  67
PRO A 330
 None
 1.12A 6ew0I-4ptsA:
undetectable		 6ew0I-4ptsA:
13.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qiw DNA-DIRECTED RNA
POLYMERASE
DNA-DIRECTED RNA
POLYMERASE SUBUNIT K
DNA-DIRECTED RNA
POLYMERASE, SUBUNIT
E'

(Thermococcus
kodakarensis) 		PF00562
(RNA_pol_Rpb2_6)
PF00575
(S1)
PF01192
(RNA_pol_Rpb6)
PF03876
(SHS2_Rpb7-N)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF04566
(RNA_pol_Rpb2_4)
PF04567
(RNA_pol_Rpb2_5) 		4 LEU B1049
ARG K  11
PRO E  61
ARG B1122
 None
 1.27A 6ew0I-4qiwB:
undetectable		 6ew0I-4qiwB:
6.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rnx NADPH DEHYDROGENASE
1

(Saccharomyces
pastorianus) 		PF00724
(Oxidored_FMN) 		4 LEU A 192
THR A 314
ARG A  92
ARG A 197
 None
None
FMN  A 501 (-2.9A)
FMN  A 501 (-3.8A)
 1.41A 6ew0I-4rnxA:
undetectable		 6ew0I-4rnxA:
13.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tx2 NON-RIBOSOMAL
PEPTIDE SYNTHETASE

(Actinoplanes
teichomyceticus) 		PF00668
(Condensation) 		4 LEU B 346
ARG B  23
PRO B 357
ARG B 355
 None
 1.31A 6ew0I-4tx2B:
undetectable		 6ew0I-4tx2B:
10.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wis LIPID SCRAMBLASE

([Nectria]
haematococca) 		PF04547
(Anoctamin) 		4 LEU A  52
THR A 124
ARG A 115
ARG A  84
 None
 1.20A 6ew0I-4wisA:
undetectable		 6ew0I-4wisA:
6.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ykn PHOSPHATIDYLINOSITOL
3-KINASE REGULATORY
SUBUNIT
ALPHA,PHOSPHATIDYLIN
OSITOL
4,5-BISPHOSPHATE
3-KINASE CATALYTIC
SUBUNIT ALPHA
ISOFORM FUSION
PROTEIN

(Homo sapiens) 		PF00017
(SH2)
PF00454
(PI3_PI4_kinase)
PF00613
(PI3Ka)
PF00792
(PI3K_C2)
PF00794
(PI3K_rbd)
PF02192
(PI3K_p85B)
PF16454
(PI3K_P85_iSH2) 		4 LEU A1831
THR A1908
ARG A1818
PRO A1835
 None
 1.29A 6ew0I-4yknA:
undetectable		 6ew0I-4yknA:
4.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5afu DYNACTIN

(Sus scrofa) 		PF00022
(Actin) 		4 LEU J  20
THR J 106
PRO J  84
ARG J  87
 None
 1.40A 6ew0I-5afuJ:
undetectable		 6ew0I-5afuJ:
11.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cdi CHAPERONIN 60B1

(Chlamydomonas
reinhardtii) 		PF00118
(Cpn60_TCP1) 		4 LEU A 373
THR A 297
PRO A 280
ARG A 286
 None
 1.18A 6ew0I-5cdiA:
undetectable		 6ew0I-5cdiA:
9.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dld UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE

(Burkholderia
vietnamiensis) 		PF02350
(Epimerase_2) 		4 LEU A 325
THR A 289
ARG A 339
ARG A 352
 ACT  A 506 (-3.9A)
None
None
None
 1.35A 6ew0I-5dldA:
undetectable		 6ew0I-5dldA:
12.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e78 BIFUNCTIONAL
P-450/NADPH-P450
REDUCTASE

(Bacillus
megaterium) 		PF00067
(p450) 		4 LEU A 277
THR A 411
PRO A 376
ARG A 323
 None
 1.18A 6ew0I-5e78A:
undetectable		 6ew0I-5e78A:
10.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e78 BIFUNCTIONAL
P-450/NADPH-P450
REDUCTASE

(Bacillus
megaterium) 		PF00067
(p450) 		4 LEU A 277
THR A 411
PRO A 376
ARG A 378
 None
 1.20A 6ew0I-5e78A:
undetectable		 6ew0I-5e78A:
10.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e7p CELL DIVISION
CONTROL PROTEIN
CDC48

(Mycolicibacterium
smegmatis) 		PF00004
(AAA)
PF02359
(CDC48_N) 		4 LEU A 377
THR A 366
ARG A 305
ARG A 111
 None
 1.26A 6ew0I-5e7pA:
undetectable		 6ew0I-5e7pA:
7.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5erb POLYKETIDE SYNTHASE

(Bacillus
amyloliquefaciens) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		4 LEU A 527
ARG A 480
PRO A 607
ARG A 473
 None
 1.25A 6ew0I-5erbA:
undetectable		 6ew0I-5erbA:
8.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f1n MHC CLASS I ANTIGEN

(Canis lupus) 		PF00129
(MHC_I)
PF07654
(C1-set) 		4 LEU A  81
THR A  97
ARG A  75
PRO A  20
 None
 1.25A 6ew0I-5f1nA:
undetectable		 6ew0I-5f1nA:
15.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fic SPHINGOMYELIN
PHOSPHODIESTERASE

(Mus musculus) 		PF00149
(Metallophos) 		4 LEU A 259
THR A 203
ARG A 198
ARG A 533
 None
None
PO4  A 710 (-3.5A)
None
 1.26A 6ew0I-5ficA:
undetectable		 6ew0I-5ficA:
10.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fz5 TRANSCRIPTION
INITIATION FACTOR
IIF SUBUNIT ALPHA
TRANSCRIPTION
INITIATION FACTOR
IIF SUBUNIT BETA

(Saccharomyces
cerevisiae) 		PF02270
(TFIIF_beta)
PF05793
(TFIIF_alpha) 		4 LEU Q 103
THR R 105
PRO R  74
ARG R  72
 None
 1.25A 6ew0I-5fz5Q:
undetectable		 6ew0I-5fz5Q:
7.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ggy IRON(III) ABC
TRANSPORTER,
PERIPLASMIC
IRON-COMPOUND-BINDIN
G PROTEIN

(Vibrio cholerae) 		PF01497
(Peripla_BP_2) 		4 LEU A 312
THR A 201
ARG A 290
ARG A 302
 None
 1.26A 6ew0I-5ggyA:
undetectable		 6ew0I-5ggyA:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5glg FUMARATE REDUCTASE 2

(Saccharomyces
cerevisiae) 		PF00890
(FAD_binding_2) 		4 LEU A 368
THR A 252
PRO A 162
ARG A 156
 None
FAD  A 602 (-4.1A)
None
None
 1.39A 6ew0I-5glgA:
undetectable		 6ew0I-5glgA:
10.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h64 SERINE/THREONINE-PRO
TEIN KINASE MTOR

(Homo sapiens) 		PF00454
(PI3_PI4_kinase)
PF02259
(FAT)
PF02260
(FATC)
PF08771
(FRB_dom)
PF11865
(DUF3385) 		4 LEU A2236
THR A2173
PRO A2169
ARG A2168
 None
 1.35A 6ew0I-5h64A:
undetectable		 6ew0I-5h64A:
2.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hiw CYTOCHROME P450
CYP260B1

(Sorangium
cellulosum) 		PF00067
(p450) 		4 LEU A 244
THR A 269
PRO A 384
ARG A 377
 None
 1.29A 6ew0I-5hiwA:
undetectable		 6ew0I-5hiwA:
11.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iva LPS-ASSEMBLY
LIPOPROTEIN LPTE
LPS-ASSEMBLY PROTEIN
LPTD

(Pseudomonas
aeruginosa) 		PF04390
(LptE)
PF04453
(OstA_C) 		4 THR A 227
ARG B 130
PRO B  32
ARG A 181
 None
 1.31A 6ew0I-5ivaA:
undetectable		 6ew0I-5ivaA:
8.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k9h 0940_GH29

(unidentified) 		PF00754
(F5_F8_type_C)
PF01120
(Alpha_L_fucos) 		4 LEU A 373
THR A 344
ARG A 403
ARG A 356
 None
None
None
SCN  A 626 (-3.2A)
 1.20A 6ew0I-5k9hA:
undetectable		 6ew0I-5k9hA:
9.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5law E3 UBIQUITIN-PROTEIN
LIGASE MDM2

(Homo sapiens) 		PF02201
(SWIB) 		4 LEU A  54
THR A 101
PRO A  30
ARG A  29
 6SJ  A 201 (-4.2A)
None
None
None
 1.06A 6ew0I-5lawA:
undetectable		 6ew0I-5lawA:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lhk LEUCINE
AMINOPEPTIDASE 2,
CHLOROPLASTIC

(Streptomyces
sp. BC16019) 		PF00883
(Peptidase_M17)
PF02789
(Peptidase_M17_N) 		4 LEU A 171
THR A 161
ARG A  94
ARG A 406
 None
 1.27A 6ew0I-5lhkA:
undetectable		 6ew0I-5lhkA:
9.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mqc VP1

(Black queen
cell virus) 		PF08762
(CRPV_capsid) 		4 THR A 237
ARG A  54
PRO A  77
ARG A  78
 None
 1.01A 6ew0I-5mqcA:
undetectable		 6ew0I-5mqcA:
13.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5n5n TUBULIN BETA CHAIN

(Homo sapiens) 		no annotation 4 LEU B 230
THR B 276
ARG B 320
PRO B 360
 None
 0.62A 6ew0I-5n5nB:
undetectable		 6ew0I-5n5nB:
93.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n9x ADENYLATION DOMAIN

(Streptomyces
sp.) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		4 LEU A  86
THR A  19
PRO A 153
ARG A  66
 None
 1.08A 6ew0I-5n9xA:
undetectable		 6ew0I-5n9xA:
9.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vtm TYPE II SECRETION
SYSTEM PROTEIN J
TYPE II SECRETION
SYSTEM PROTEIN K

(Pseudomonas
aeruginosa) 		no annotation 4 LEU W 174
THR W 165
ARG X 307
PRO W 203
 None
 1.41A 6ew0I-5vtmW:
undetectable		 6ew0I-5vtmW:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w0x TIP41-LIKE PROTEIN

(Mus musculus) 		no annotation 4 LEU A 183
THR A 215
PRO A 235
ARG A 188
 None
 1.35A 6ew0I-5w0xA:
undetectable		 6ew0I-5w0xA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xgj PHOSPHATIDYLINOSITOL
4,5-BISPHOSPHATE
3-KINASE CATALYTIC
SUBUNIT ALPHA
ISOFORM

(Homo sapiens) 		no annotation 4 LEU A 831
THR A 908
ARG A 818
PRO A 835
 None
 1.35A 6ew0I-5xgjA:
undetectable		 6ew0I-5xgjA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xxi CYTOCHROME P450 2C9

(Homo sapiens) 		no annotation 4 LEU A 310
THR A 450
PRO A 409
ARG A 357
 None
 1.31A 6ew0I-5xxiA:
undetectable		 6ew0I-5xxiA:
9.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ywp JEV E PROTEIN

(Japanese
encephalitis
virus) 		no annotation 4 LEU A 280
THR A 129
PRO A 171
ARG A 193
 None
 1.22A 6ew0I-5ywpA:
undetectable		 6ew0I-5ywpA:
14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z02 E3 UBIQUITIN-PROTEIN
LIGASE MDM2

(Homo sapiens) 		no annotation 4 LEU A  33
THR A  80
PRO A   9
ARG A   8
 NUT  A 101 (-4.1A)
None
None
None
 1.40A 6ew0I-5z02A:
undetectable		 6ew0I-5z02A:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zbl CYTOKININ RIBOSIDE
5'-MONOPHOSPHATE
PHOSPHORIBOHYDROLASE

(Corynebacterium
glutamicum) 		no annotation 4 LEU A 141
THR A  17
PRO A 178
ARG A  41
 None
 1.37A 6ew0I-5zblA:
undetectable		 6ew0I-5zblA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zln TOLL-LIKE RECEPTOR 9

(Mus musculus) 		no annotation 4 LEU A  37
THR A  66
PRO A  54
ARG A  55
 None
 1.27A 6ew0I-5zlnA:
undetectable		 6ew0I-5zlnA:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6btg FUCULOSE PHOSPHATE
ALDOLASE

(Bacillus
thuringiensis) 		no annotation 4 LEU A 138
THR A  96
ARG A  87
ARG A 149
 None
 1.37A 6ew0I-6btgA:
undetectable		 6ew0I-6btgA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bz0 DIHYDROLIPOYL
DEHYDROGENASE

(Acinetobacter
baumannii) 		no annotation 4 LEU A 434
THR A 368
PRO A 323
ARG A 321
 None
CL  A 504 ( 4.1A)
None
None
 1.35A 6ew0I-6bz0A:
undetectable		 6ew0I-6bz0A:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fkh ATP SYNTHASE SUBUNIT
ALPHA, CHLOROPLASTIC

(Spinacia
oleracea) 		no annotation 4 LEU C 387
THR C 437
PRO C 356
ARG C 355
 None
None
ATP  C 602 ( 4.2A)
ATP  C 602 ( 4.1A)
 1.25A 6ew0I-6fkhC:
undetectable		 6ew0I-6fkhC:
23.60