SIMILAR PATTERNS OF AMINO ACIDS FOR 6EW0_I_TA1I501_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a9w HEMOGLOBIN (BETA
CHAIN)

(Homo sapiens) 		PF00042
(Globin) 		5 LEU E  32
LEU E  48
HIS E  63
SER E  70
LEU E  31
 None
None
HEM  E 147 ( 4.5A)
HEM  E 147 (-3.3A)
None
 1.10A 6ew0I-1a9wE:
undetectable		 6ew0I-1a9wE:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e4o MALTODEXTRIN
PHOSPHORYLASE

(Escherichia
coli) 		PF00343
(Phosphorylase) 		5 LEU A 707
LEU A 703
ALA A 587
LEU A 727
LEU A 580
 None
 1.11A 6ew0I-1e4oA:
5.0		 6ew0I-1e4oA:
7.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h8l CARBOXYPEPTIDASE
GP180 RESIDUES
503-882

(Lophonetta
specularioides) 		PF00246
(Peptidase_M14)
PF13620
(CarboxypepD_reg) 		5 VAL A 368
ASP A 369
LEU A 176
LEU A 213
GLN A 297
 None
 1.12A 6ew0I-1h8lA:
undetectable		 6ew0I-1h8lA:
11.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ihb CYCLIN-DEPENDENT
KINASE 6 INHIBITOR

(Homo sapiens) 		PF13637
(Ank_4)
PF13857
(Ank_5) 		5 LEU A  21
LEU A  18
ALA A  61
LEU A   9
GLN A  26
 None
 1.09A 6ew0I-1ihbA:
undetectable		 6ew0I-1ihbA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jcn INOSINE
MONOPHOSPHATE
DEHYDROGENASE I

(Homo sapiens) 		PF00478
(IMPDH)
PF00571
(CBS) 		5 VAL A 104
LEU A  55
LEU A  61
ALA A 248
LEU A 297
 None
 1.13A 6ew0I-1jcnA:
undetectable		 6ew0I-1jcnA:
7.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m54 CYSTATHIONINE
BETA-SYNTHASE

(Homo sapiens) 		PF00291
(PALP) 		5 ASP A 120
LEU A 251
HIS A 232
ALA A 231
GLN A 243
 None
 1.14A 6ew0I-1m54A:
undetectable		 6ew0I-1m54A:
13.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1poi GLUTACONATE COENZYME
A-TRANSFERASE

(Acidaminococcus
fermentans) 		PF01144
(CoA_trans) 		5 LEU A 301
LEU A 304
ALA A  34
LEU A 293
ARG A 300
 None
 1.06A 6ew0I-1poiA:
undetectable		 6ew0I-1poiA:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t6p PHENYLALANINE
AMMONIA-LYASE

(Rhodotorula
toruloides) 		PF00221
(Lyase_aromatic) 		5 LEU A 532
ALA A 701
SER A 704
LEU A 528
LEU A 711
 None
 1.13A 6ew0I-1t6pA:
undetectable		 6ew0I-1t6pA:
7.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tt7 YHFP

(Bacillus
subtilis) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 LEU A 233
LEU A 230
ALA A 159
LEU A 155
LEU A 171
 None
 0.95A 6ew0I-1tt7A:
2.5		 6ew0I-1tt7A:
14.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uzg MAJOR ENVELOPE
PROTEIN E

(Dengue virus) 		PF00869
(Flavi_glycoprot)
PF02832
(Flavi_glycop_C) 		5 GLU A  26
LEU A 179
LEU A 173
LEU A 285
LEU A 281
 None
 1.12A 6ew0I-1uzgA:
undetectable		 6ew0I-1uzgA:
11.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w8a SLIT PROTEIN

(Drosophila
melanogaster) 		PF00560
(LRR_1)
PF01462
(LRRNT)
PF01463
(LRRCT)
PF13855
(LRR_8) 		5 GLU A 616
LEU A 602
LEU A 577
ALA A 614
LEU A 642
 None
 1.07A 6ew0I-1w8aA:
undetectable		 6ew0I-1w8aA:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xb7 STEROID HORMONE
RECEPTOR ERR1

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 LEU A 412
LEU A 415
ALA A 429
ARG A 411
GLN A 407
 None
 0.94A 6ew0I-1xb7A:
undetectable		 6ew0I-1xb7A:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zc6 PROBABLE
N-ACETYLGLUCOSAMINE
KINASE

(Chromobacterium
violaceum) 		PF01869
(BcrAD_BadFG) 		5 ASP A 229
LEU A 256
LEU A 276
LEU A 129
LEU A 219
 None
 1.11A 6ew0I-1zc6A:
undetectable		 6ew0I-1zc6A:
14.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a14 INDOLETHYLAMINE
N-METHYLTRANSFERASE

(Homo sapiens) 		PF01234
(NNMT_PNMT_TEMT) 		5 VAL A 225
LEU A  45
ALA A 257
LEU A  54
LEU A 187
 None
 1.04A 6ew0I-2a14A:
2.5		 6ew0I-2a14A:
14.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a2j PYRIDOXAMINE
5'-PHOSPHATE OXIDASE

(Mycobacterium
tuberculosis) 		PF01243
(Putative_PNPOx)
PF10590
(PNP_phzG_C) 		5 LEU A  37
LEU A 219
ALA A 121
LEU A  44
LEU A  83
 None
 1.10A 6ew0I-2a2jA:
undetectable		 6ew0I-2a2jA:
13.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cuk GLYCERATE
DEHYDROGENASE/GLYOXY
LATE REDUCTASE

(Thermus
thermophilus) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		5 ASP A  53
LEU A  22
ALA A  70
LEU A 301
LEU A  66
 None
 1.12A 6ew0I-2cukA:
2.0		 6ew0I-2cukA:
15.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dlc TYROSYL-TRNA
SYNTHETASE,
CYTOPLASMIC

(Saccharomyces
cerevisiae) 		PF00579
(tRNA-synt_1b) 		5 ASP X 191
LEU X 203
ALA X 152
LEU X 172
GLN X 128
 YMP  X 601 (-3.2A)
None
None
None
None
 1.08A 6ew0I-2dlcX:
undetectable		 6ew0I-2dlcX:
14.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e5a LIPOYLTRANSFERASE 1

(Bos taurus) 		no annotation 5 VAL A 114
LEU A  39
ALA A 110
LEU A  89
ARG A  41
 None
 1.10A 6ew0I-2e5aA:
undetectable		 6ew0I-2e5aA:
15.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f6h MYOSIN-2

(Saccharomyces
cerevisiae) 		PF01843
(DIL) 		5 LEU X  95
LEU X  99
ALA X 135
SER X 138
LEU X  79
 None
 1.11A 6ew0I-2f6hX:
undetectable		 6ew0I-2f6hX:
10.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ft3 BIGLYCAN

(Bos taurus) 		PF01462
(LRRNT)
PF13855
(LRR_8) 		5 ASP A 170
LEU A 200
LEU A 184
LEU A 198
LEU A 174
 None
 1.07A 6ew0I-2ft3A:
undetectable		 6ew0I-2ft3A:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g2o MALONYL COA-ACYL
CARRIER PROTEIN
TRANSACYLASE

(Escherichia
coli) 		PF00698
(Acyl_transf_1) 		5 VAL A 100
LEU A  44
ALA A 110
GLN A  14
LEU A  93
 None
None
None
None
SO4  A1001 (-4.3A)
 1.12A 6ew0I-2g2oA:
undetectable		 6ew0I-2g2oA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lrt UNCHARACTERIZED
PROTEIN

(Bacteroides
vulgatus) 		PF13905
(Thioredoxin_8) 		5 VAL A 111
GLU A 131
LEU A   3
SER A 116
LEU A  30
 None
 1.07A 6ew0I-2lrtA:
undetectable		 6ew0I-2lrtA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rfz CELLULOSE
1,4-BETA-CELLOBIOSID
ASE

(Melanocarpus
albomyces) 		PF00840
(Glyco_hydro_7) 		5 VAL A 147
GLU A 212
LEU A  90
LEU A  14
LEU A  92
 None
CTR  A 431 (-3.3A)
None
None
None
 1.08A 6ew0I-2rfzA:
undetectable		 6ew0I-2rfzA:
12.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vf8 EXCINUCLEASE ABC
SUBUNIT A

(Deinococcus
radiodurans) 		PF00005
(ABC_tran) 		5 LEU A 424
LEU A 434
SER A 381
LEU A 420
LEU A 368
 None
 0.97A 6ew0I-2vf8A:
undetectable		 6ew0I-2vf8A:
7.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w55 XANTHINE
DEHYDROGENASE

(Rhodobacter
capsulatus) 		PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2) 		5 VAL B 190
LEU B 100
LEU B  86
ALA B 183
LEU B  35
 None
 1.09A 6ew0I-2w55B:
undetectable		 6ew0I-2w55B:
6.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w8s PHOSPHONATE
MONOESTER HYDROLASE

(Paraburkholderia
caryophylli) 		PF00884
(Sulfatase)
PF16347
(DUF4976) 		5 VAL A 373
ASP A 372
LEU A  40
LEU A  37
LEU A 398
 None
 1.01A 6ew0I-2w8sA:
undetectable		 6ew0I-2w8sA:
9.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x47 MACRO
DOMAIN-CONTAINING
PROTEIN 1

(Homo sapiens) 		PF01661
(Macro) 		5 VAL A 305
ASP A 310
GLU A 311
LEU A 251
LEU A 318
 None
 1.09A 6ew0I-2x47A:
undetectable		 6ew0I-2x47A:
16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xwb COMPLEMENT C3B
ALPHA' CHAIN

(Homo sapiens) 		PF00207
(A2M)
PF01759
(NTR)
PF07677
(A2M_recep)
PF07678
(A2M_comp)
PF10569
(Thiol-ester_cl) 		5 ASP B1200
GLU B1199
LEU B1180
ALA B1192
LEU B1218
 None
 1.05A 6ew0I-2xwbB:
undetectable		 6ew0I-2xwbB:
6.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yg1 CELLULOSE
1,4-BETA-CELLOBIOSID
ASE

(Heterobasidion
annosum) 		PF00840
(Glyco_hydro_7) 		5 VAL A 149
GLU A 214
LEU A  91
LEU A  14
LEU A  93
 None
 0.96A 6ew0I-2yg1A:
undetectable		 6ew0I-2yg1A:
10.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zgd 3 REPEAT SYNTHETIC
ANKYRIN

(-) 		PF12796
(Ank_2) 		5 VAL A  40
ASP A  38
GLU A  39
LEU A 105
ALA A  32
 None
CD  A 413 ( 2.4A)
CD  A 410 ( 2.1A)
None
None
 1.09A 6ew0I-2zgdA:
undetectable		 6ew0I-2zgdA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zwv PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE

(Thermus
thermophilus) 		PF05175
(MTS) 		5 ASP A  51
LEU A 185
LEU A 203
ALA A  97
LEU A 182
 None
 1.12A 6ew0I-2zwvA:
2.5		 6ew0I-2zwvA:
11.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bh1 UPF0371 PROTEIN
DIP2346

(Corynebacterium
diphtheriae) 		PF08903
(DUF1846) 		5 LEU A 453
LEU A 478
SER A 408
LEU A 450
LEU A 403
 None
None
None
None
GOL  A 507 (-4.2A)
 0.99A 6ew0I-3bh1A:
undetectable		 6ew0I-3bh1A:
11.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3blx ISOCITRATE
DEHYDROGENASE [NAD]
SUBUNIT 2

(Saccharomyces
cerevisiae) 		PF00180
(Iso_dh) 		5 GLU B  54
LEU B  99
ALA B  73
SER B  76
LEU B 103
 None
 1.12A 6ew0I-3blxB:
undetectable		 6ew0I-3blxB:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cq9 UNCHARACTERIZED
PROTEIN LP_1622

(Lactobacillus
plantarum) 		PF04263
(TPK_catalytic) 		5 GLU A 151
LEU A 167
LEU A 176
SER A 137
LEU A 206
 None
 1.12A 6ew0I-3cq9A:
undetectable		 6ew0I-3cq9A:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f95 BETA-GLUCOSIDASE

(Pseudoalteromonas
sp. BB1) 		no annotation 5 ASP A 685
LEU A 650
LEU A 673
ALA A 663
LEU A 642
 None
 1.01A 6ew0I-3f95A:
undetectable		 6ew0I-3f95A:
24.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3goz LEUCINE-RICH
REPEAT-CONTAINING
PROTEIN

(Legionella
pneumophila) 		no annotation 6 GLU A  41
LEU A  56
LEU A  85
ALA A  45
LEU A  27
LEU A   7
 None
 1.34A 6ew0I-3gozA:
undetectable		 6ew0I-3gozA:
14.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gqp HEMOGLOBIN SUBUNIT
BETA-A/B

(Felis catus) 		PF00042
(Globin) 		5 LEU B  32
LEU B  48
HIS B  63
SER B  70
LEU B  31
 None
None
HEM  B 148 (-4.2A)
HEM  B 148 (-2.8A)
None
 1.13A 6ew0I-3gqpB:
undetectable		 6ew0I-3gqpB:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hjv MALONYL COA-ACYL
CARRIER PROTEIN
TRANSACYLASE

(Vibrio cholerae) 		PF00698
(Acyl_transf_1) 		5 VAL A 105
LEU A  49
ALA A 115
GLN A  19
LEU A  98
 None
None
None
CL  A 328 (-3.5A)
None
 1.13A 6ew0I-3hjvA:
undetectable		 6ew0I-3hjvA:
13.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hl1 FERRITIN LIKE
PROTEIN

(Caulobacter
vibrioides) 		PF12902
(Ferritin-like) 		5 VAL A 183
LEU A  10
LEU A   7
ALA A 194
GLN A  15
 None
 0.87A 6ew0I-3hl1A:
undetectable		 6ew0I-3hl1A:
14.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3im8 MALONYL ACYL CARRIER
PROTEIN TRANSACYLASE

(Streptococcus
pneumoniae) 		PF00698
(Acyl_transf_1) 		5 VAL A  98
LEU A  44
ALA A 108
GLN A  14
LEU A  91
 None
 1.08A 6ew0I-3im8A:
undetectable		 6ew0I-3im8A:
14.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3khz PUTATIVE DIPEPTIDASE
SACOL1801

(Staphylococcus
aureus) 		PF01546
(Peptidase_M20) 		5 ASP A 251
GLU A 264
LEU A 292
ALA A 222
LEU A 284
 None
 1.12A 6ew0I-3khzA:
undetectable		 6ew0I-3khzA:
10.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lmd GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE

(Corynebacterium
glutamicum) 		PF00348
(polyprenyl_synt) 		5 VAL A 277
GLU A 273
LEU A 289
SER A 305
LEU A 258
 None
 1.07A 6ew0I-3lmdA:
undetectable		 6ew0I-3lmdA:
10.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oak TRANSCRIPTION FACTOR
IWS1

(Saccharomyces
cerevisiae) 		PF08711
(Med26) 		6 ASP A 163
GLU A 164
LEU A 225
LEU A 242
ARG A 222
LEU A 217
 None
 1.29A 6ew0I-3oakA:
undetectable		 6ew0I-3oakA:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s4w FANCONI ANEMIA GROUP
D2 PROTEIN HOMOLOG

(Mus musculus) 		PF14631
(FancD2) 		5 ASP B 141
LEU B  55
LEU B  66
LEU B  50
LEU B  81
 None
 0.99A 6ew0I-3s4wB:
undetectable		 6ew0I-3s4wB:
5.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3trd ALPHA/BETA HYDROLASE

(Coxiella
burnetii) 		PF00561
(Abhydrolase_1) 		5 VAL A 166
LEU A 200
LEU A 204
ALA A 132
LEU A 196
 None
 1.04A 6ew0I-3trdA:
3.4		 6ew0I-3trdA:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tsr RIBONUCLEASE
INHIBITOR

(Mus musculus) 		PF13516
(LRR_6) 		5 LEU E 253
LEU E 281
SER E 173
LEU E 224
ARG E 254
 None
 1.06A 6ew0I-3tsrE:
undetectable		 6ew0I-3tsrE:
11.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wxb UNCHARACTERIZED
PROTEIN

(Gallus gallus) 		PF00106
(adh_short) 		5 ASP A 245
LEU A  26
LEU A  29
ALA A 153
LEU A 206
 None
 1.09A 6ew0I-3wxbA:
6.4		 6ew0I-3wxbA:
14.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3x17 ENDOGLUCANASE

(uncultured
bacterium) 		no annotation 5 ASP B 136
LEU B 465
ALA B 141
LEU B 458
LEU B 488
 None
 1.12A 6ew0I-3x17B:
undetectable		 6ew0I-3x17B:
10.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cp6 CHOLINE BINDING
PROTEIN PCPA

(Streptococcus
pneumoniae) 		PF13306
(LRR_5) 		5 LEU A 175
LEU A 153
ALA A 207
LEU A 200
LEU A 217
 None
 1.01A 6ew0I-4cp6A:
undetectable		 6ew0I-4cp6A:
11.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h2l BETA GLOBIN

(Peromyscus
maniculatus) 		PF00042
(Globin) 		5 LEU B  32
LEU B  48
HIS B  63
SER B  70
LEU B  31
 None
None
HEM  B 201 (-4.2A)
HEM  B 201 (-3.1A)
None
 1.13A 6ew0I-4h2lB:
undetectable		 6ew0I-4h2lB:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4haq GH7 FAMILY PROTEIN

(Limnoria
quadripunctata) 		PF00840
(Glyco_hydro_7) 		5 VAL A 168
GLU A 233
LEU A 111
LEU A  36
LEU A 113
 None
 1.01A 6ew0I-4haqA:
undetectable		 6ew0I-4haqA:
10.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iv6 ACYL-COA
DEHYDROGENASE FADE3

(Mycolicibacterium
smegmatis) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		5 VAL A 240
GLU A 239
LEU A 184
LEU A 162
LEU A 223
 None
 1.13A 6ew0I-4iv6A:
undetectable		 6ew0I-4iv6A:
11.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jkg PRE-MRNA-PROCESSING-
SPLICING FACTOR 8

(Homo sapiens) 		PF12134
(PRP8_domainIV) 		6 VAL B1785
LEU B1919
LEU B1936
ALA B1806
LEU B1817
LEU B1905
 None
 1.49A 6ew0I-4jkgB:
undetectable		 6ew0I-4jkgB:
16.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kpn NUCLEOSIDE
N-RIBOHYDROLASE 1

(Physcomitrella
patens) 		PF01156
(IU_nuc_hydro) 		5 VAL A 266
LEU A 234
LEU A 223
ALA A  37
LEU A 141
 None
 1.07A 6ew0I-4kpnA:
5.3		 6ew0I-4kpnA:
14.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kt1 LEUCINE-RICH
REPEAT-CONTAINING
G-PROTEIN COUPLED
RECEPTOR 4

(Homo sapiens) 		PF01462
(LRRNT)
PF13516
(LRR_6)
PF13855
(LRR_8) 		5 LEU A  93
ALA A 124
LEU A 117
GLN A 113
LEU A 134
 None
 1.13A 6ew0I-4kt1A:
undetectable		 6ew0I-4kt1A:
10.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kt1 LEUCINE-RICH
REPEAT-CONTAINING
G-PROTEIN COUPLED
RECEPTOR 4

(Homo sapiens) 		PF01462
(LRRNT)
PF13516
(LRR_6)
PF13855
(LRR_8) 		5 LEU A 208
LEU A 184
ALA A 243
LEU A 232
LEU A 250
 None
 1.12A 6ew0I-4kt1A:
undetectable		 6ew0I-4kt1A:
10.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4md8 CASEIN KINASE II
SUBUNIT ALPHA

(Homo sapiens) 		PF00069
(Pkinase) 		5 ASP E  25
GLU E  22
LEU E 111
LEU E  70
LEU E  97
 None
 1.04A 6ew0I-4md8E:
undetectable		 6ew0I-4md8E:
11.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mqj HEMOGLOBIN SUBUNIT
GAMMA-2

(Homo sapiens) 		PF00042
(Globin) 		5 LEU B  32
LEU B  48
HIS B  63
SER B  70
LEU B  31
 None
None
HEM  B 201 (-4.3A)
HEM  B 201 (-3.5A)
None
 1.11A 6ew0I-4mqjB:
undetectable		 6ew0I-4mqjB:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nru RNA DEPENDENT RNA
POLYMERASE

(Norwalk virus) 		PF00680
(RdRP_1) 		5 VAL A 324
ASP A 354
ALA A 320
LEU A 367
LEU A 379
 None
 1.08A 6ew0I-4nruA:
undetectable		 6ew0I-4nruA:
9.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oj5 TAILSPIKE PROTEIN

(Escherichia
virus CBA120) 		no annotation 5 VAL A 337
LEU A 354
LEU A 387
ALA A 283
LEU A 329
 None
 1.02A 6ew0I-4oj5A:
undetectable		 6ew0I-4oj5A:
7.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p22 UBIQUITIN-LIKE
MODIFIER-ACTIVATING
ENZYME 1

(Homo sapiens) 		PF00899
(ThiF)
PF16190
(E1_FCCH)
PF16191
(E1_4HB) 		5 ASP A 111
LEU A 151
ALA A 128
SER A 131
LEU A  76
 None
 1.00A 6ew0I-4p22A:
undetectable		 6ew0I-4p22A:
10.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pb6 VP1

(Feline
calicivirus) 		PF00915
(Calici_coat) 		5 VAL A 367
GLU A 555
LEU A 588
LEU A 594
ARG A 372
 None
 1.09A 6ew0I-4pb6A:
undetectable		 6ew0I-4pb6A:
8.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pu5 TOXIN-ANTITOXIN
SYSTEM TOXIN HIPA
FAMILY

(Shewanella
oneidensis) 		PF07804
(HipA_C)
PF13657
(Couple_hipA) 		5 VAL A 431
ASP A 430
GLU A 427
LEU A 293
LEU A 297
 None
 1.12A 6ew0I-4pu5A:
undetectable		 6ew0I-4pu5A:
11.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qxe LEUCINE-RICH
REPEAT-CONTAINING
G-PROTEIN COUPLED
RECEPTOR 4, LINKER,
VARIABLE LYMPHOCYTE
RECEPTOR B

(Eptatretus
burgeri;
Homo sapiens) 		PF01462
(LRRNT)
PF11921
(DUF3439)
PF13516
(LRR_6)
PF13855
(LRR_8) 		5 LEU A  93
ALA A 124
LEU A 117
GLN A 113
LEU A 134
 None
 1.03A 6ew0I-4qxeA:
undetectable		 6ew0I-4qxeA:
10.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qxe LEUCINE-RICH
REPEAT-CONTAINING
G-PROTEIN COUPLED
RECEPTOR 4, LINKER,
VARIABLE LYMPHOCYTE
RECEPTOR B

(Eptatretus
burgeri;
Homo sapiens) 		PF01462
(LRRNT)
PF11921
(DUF3439)
PF13516
(LRR_6)
PF13855
(LRR_8) 		5 LEU A 208
LEU A 184
ALA A 243
LEU A 232
LEU A 250
 None
 1.11A 6ew0I-4qxeA:
undetectable		 6ew0I-4qxeA:
10.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r6g LEUCINE RICH REPEATS
DLRR_K

(synthetic
construct) 		PF12799
(LRR_4)
PF13516
(LRR_6)
PF13855
(LRR_8) 		5 GLU A 330
LEU A 372
LEU A 377
ALA A 359
LEU A 370
 None
 1.04A 6ew0I-4r6gA:
undetectable		 6ew0I-4r6gA:
10.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4toi 30S RIBOSOMAL
PROTEIN S2,RIBOSOMAL
PROTEIN S1

(Escherichia
coli) 		PF00318
(Ribosomal_S2)
PF00575
(S1) 		5 VAL A 196
ASP A 197
LEU A 214
GLN A  89
LEU A  57
 None
 1.06A 6ew0I-4toiA:
undetectable		 6ew0I-4toiA:
14.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ufs LEUCINE-RICH
REPEAT-CONTAINING
G-PROTEIN COUPLED
RECEPTOR 5

(Homo sapiens) 		PF00560
(LRR_1)
PF01462
(LRRNT)
PF13855
(LRR_8) 		5 LEU A 217
LEU A 193
ALA A 252
LEU A 241
LEU A 259
 None
 1.09A 6ew0I-4ufsA:
undetectable		 6ew0I-4ufsA:
11.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xgc ORIGIN RECOGNITION
COMPLEX SUBUNIT 3
ORIGIN RECOGNITION
COMPLEX SUBUNIT 5

(Drosophila
melanogaster) 		PF07034
(ORC3_N)
PF13191
(AAA_16)
PF14630
(ORC5_C) 		5 GLU E  73
LEU C 209
LEU C 240
LEU C 132
LEU C 140
 None
 1.05A 6ew0I-4xgcE:
undetectable		 6ew0I-4xgcE:
13.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xwu INOSINE-5'-MONOPHOSP
HATE
DEHYDROGENASE,INOSIN
E-5'-MONOPHOSPHATE
DEHYDROGENASE

(Eremothecium
gossypii) 		PF00478
(IMPDH) 		5 VAL A 110
LEU A  61
LEU A  67
ALA A 251
LEU A 300
 None
 1.14A 6ew0I-4xwuA:
undetectable		 6ew0I-4xwuA:
11.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yxf MUPS

(Pseudomonas
fluorescens) 		PF13561
(adh_short_C2) 		5 GLU A  89
LEU A 180
LEU A 176
ALA A 138
LEU A 184
 None
 0.95A 6ew0I-4yxfA:
undetectable		 6ew0I-4yxfA:
17.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yxf MUPS

(Pseudomonas
fluorescens) 		PF13561
(adh_short_C2) 		5 VAL A  85
GLU A  89
LEU A 180
LEU A 176
LEU A 184
 None
 1.12A 6ew0I-4yxfA:
undetectable		 6ew0I-4yxfA:
17.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b48 2-OXOACID--FERREDOXI
N OXIDOREDUCTASE
ALPHA SUBUNIT

(Sulfurisphaera
tokodaii) 		PF01558
(POR)
PF01855
(POR_N) 		5 VAL A 102
LEU A  88
LEU A  69
LEU A 130
LEU A 117
 None
 1.08A 6ew0I-5b48A:
undetectable		 6ew0I-5b48A:
7.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5epg ALDEHYDE OXIDASE

(Homo sapiens) 		PF00111
(Fer2)
PF00941
(FAD_binding_5)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2)
PF03450
(CO_deh_flav_C) 		5 LEU A  31
LEU A  37
ALA A  84
LEU A  27
LEU A   7
 None
 0.98A 6ew0I-5epgA:
undetectable		 6ew0I-5epgA:
4.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gw9 GRANULOCYTE
COLONY-STIMULATING
FACTOR

(Homo sapiens) 		PF16647
(GCSF) 		5 LEU A  32
LEU A 107
SER A 143
LEU A  36
LEU A  48
 None
 1.04A 6ew0I-5gw9A:
undetectable		 6ew0I-5gw9A:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h11 UNCHARACTERIZED
PROTEIN

(Danio rerio) 		PF07393
(Sec10) 		6 VAL A 246
ASP A 245
LEU A 307
LEU A 433
LEU A 292
GLN A 302
 None
 1.47A 6ew0I-5h11A:
undetectable		 6ew0I-5h11A:
11.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hax NUCLEOPORIN NUP170

(Chaetomium
thermophilum) 		PF08801
(Nucleoporin_N) 		5 VAL A 608
GLU A 609
LEU A 724
LEU A 734
LEU A 720
 None
 1.01A 6ew0I-5haxA:
undetectable		 6ew0I-5haxA:
8.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iv8 LPS BIOSYNTHESIS
PROTEIN

(Klebsiella
pneumoniae) 		PF04453
(OstA_C) 		5 ASP A 629
GLU A 658
LEU A 536
ALA A 632
SER A 656
 None
 1.01A 6ew0I-5iv8A:
undetectable		 6ew0I-5iv8A:
9.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ivl DEAD-BOX
ATP-DEPENDENT RNA
HELICASE CSHA

(Geobacillus
stearothermophilus) 		no annotation 5 VAL B  42
ASP B  41
GLU B 201
LEU B   9
LEU B   7
 None
 1.04A 6ew0I-5ivlB:
undetectable		 6ew0I-5ivlB:
10.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lh9 OMEGA TRANSAMINASE

(Pseudomonas sp.) 		PF00202
(Aminotran_3) 		5 LEU A 359
LEU A 355
ALA A 444
LEU A 362
LEU A 383
 None
 0.89A 6ew0I-5lh9A:
undetectable		 6ew0I-5lh9A:
10.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lpy PROTEIN
BRASSINOSTEROID
INSENSITIVE 1

(Arabidopsis
thaliana) 		PF00069
(Pkinase) 		6 LEU A1127
LEU A1123
ALA A 987
SER A 990
LEU A1080
LEU A 968
 None
 1.00A 6ew0I-5lpyA:
undetectable		 6ew0I-5lpyA:
12.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lpz PROTEIN
BRASSINOSTEROID
INSENSITIVE 1

(Arabidopsis
thaliana) 		PF00069
(Pkinase) 		6 LEU A1127
LEU A1123
ALA A 987
SER A 990
LEU A1080
LEU A 968
 None
 1.10A 6ew0I-5lpzA:
undetectable		 6ew0I-5lpzA:
12.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lst ATP-DEPENDENT DNA
HELICASE Q4

(Homo sapiens) 		PF00270
(DEAD)
PF00271
(Helicase_C) 		5 VAL A 783
ASP A 782
LEU A 720
ALA A 785
LEU A 692
 None
 1.10A 6ew0I-5lstA:
undetectable		 6ew0I-5lstA:
7.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5mjs TUBULIN BETA CHAIN

(Schizosaccharomyces
pombe) 		no annotation 5 ASP A  26
LEU A 215
HIS A 227
ALA A 231
LEU A 360
 None
 1.08A 6ew0I-5mjsA:
59.4		 6ew0I-5mjsA:
75.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5mjs TUBULIN BETA CHAIN

(Schizosaccharomyces
pombe) 		no annotation 5 GLU A  27
LEU A 215
HIS A 227
ALA A 231
LEU A 360
 None
 1.12A 6ew0I-5mjsA:
59.4		 6ew0I-5mjsA:
75.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5n5n TUBULIN BETA CHAIN

(Homo sapiens) 		no annotation 9 VAL B  23
ASP B  26
GLU B  27
LEU B 217
HIS B 229
ALA B 233
SER B 236
GLN B 281
LEU B 371
 None
 0.84A 6ew0I-5n5nB:
62.1		 6ew0I-5n5nB:
93.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5n5n TUBULIN BETA CHAIN

(Homo sapiens) 		no annotation 10 VAL B  23
ASP B  26
GLU B  27
LEU B 217
LEU B 219
HIS B 229
ALA B 233
LEU B 275
GLN B 281
LEU B 371
 None
 0.87A 6ew0I-5n5nB:
62.1		 6ew0I-5n5nB:
93.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nh1 GASDERMIN-D

(Homo sapiens) 		PF04598
(Gasdermin) 		5 GLU A 394
LEU A 469
ALA A 392
SER A 395
LEU A 441
 None
 1.13A 6ew0I-5nh1A:
undetectable		 6ew0I-5nh1A:
15.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oms CYTOCHROME P450

(Amycolatopsis
sp. ATCC 39116) 		no annotation 5 VAL A  53
GLU A  52
LEU A   9
LEU A  12
ALA A 307
 None
 0.93A 6ew0I-5omsA:
undetectable		 6ew0I-5omsA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tc3 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE

(Eremothecium
gossypii) 		PF00478
(IMPDH)
PF00571
(CBS) 		5 VAL A 110
LEU A  61
LEU A  67
ALA A 251
LEU A 300
 None
 1.11A 6ew0I-5tc3A:
undetectable		 6ew0I-5tc3A:
9.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uid AMINOTRANSFERASE
TLMJ

(Streptoalloteichus
hindustanus) 		PF01041
(DegT_DnrJ_EryC1) 		5 ALA A 159
SER A 296
ARG A 197
GLN A  51
LEU A  45
 None
 1.08A 6ew0I-5uidA:
undetectable		 6ew0I-5uidA:
12.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ux5 BIFUNCTIONAL PROTEIN
PROLINE UTILIZATION
A (PUTA)

(Corynebacterium
freiburgense) 		PF00171
(Aldedh)
PF01619
(Pro_dh) 		5 VAL A 373
ASP A 372
LEU A  15
LEU A  18
LEU A 329
 None
 1.09A 6ew0I-5ux5A:
undetectable		 6ew0I-5ux5A:
7.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w3j TUBULIN BETA CHAIN

(Saccharomyces
cerevisiae) 		PF00091
(Tubulin)
PF03953
(Tubulin_C) 		5 VAL B  23
ASP B  26
GLU B  27
GLN B 279
LEU B 361
 TA1  B 502 (-3.9A)
TA1  B 502 (-4.1A)
TA1  B 502 (-3.6A)
TA1  B 502 ( 4.3A)
TA1  B 502 (-3.7A)
 1.09A 6ew0I-5w3jB:
60.4		 6ew0I-5w3jB:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w3j TUBULIN BETA CHAIN

(Saccharomyces
cerevisiae) 		PF00091
(Tubulin)
PF03953
(Tubulin_C) 		7 VAL B  23
ASP B  26
GLU B  27
LEU B 215
LEU B 217
SER B 234
LEU B 361
 TA1  B 502 (-3.9A)
TA1  B 502 (-4.1A)
TA1  B 502 (-3.6A)
None
None
TA1  B 502 ( 4.9A)
TA1  B 502 (-3.7A)
 0.75A 6ew0I-5w3jB:
60.4		 6ew0I-5w3jB:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y59 ATP-DEPENDENT DNA
HELICASE II SUBUNIT
2

(Saccharomyces
cerevisiae) 		no annotation 5 VAL B 113
ASP B 116
LEU B  87
LEU B  29
ARG B  86
 None
 1.11A 6ew0I-5y59B:
2.7		 6ew0I-5y59B:
16.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y6q ALDEHYDE OXIDASE
MEDIUM SUBUNIT

(Methylobacillus
sp. KY4400) 		no annotation 5 LEU B  59
ALA B  87
SER B 228
LEU B  77
LEU B 170
 None
 0.84A 6ew0I-5y6qB:
undetectable		 6ew0I-5y6qB:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yl7 PSEUDOALTEROMONAS
ARCTICA PAMC 21717

(Pseudoalteromonas
arctica) 		no annotation 5 VAL A 181
ASP A 310
LEU A 167
LEU A 165
LEU A 454
 None
 1.00A 6ew0I-5yl7A:
undetectable		 6ew0I-5yl7A:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z9s GLYCOSYL HYDROLASE
FAMILY 3 PROTEIN

(Bifidobacterium
longum) 		no annotation 5 ASP A 215
LEU A 263
LEU A 264
ALA A 219
LEU A 226
 None
 0.93A 6ew0I-5z9sA:
undetectable		 6ew0I-5z9sA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b9g ATLASTIN-1

(Homo sapiens) 		no annotation 5 LEU B 300
LEU B 269
SER B 167
LEU B 304
LEU B 144
 None
 1.08A 6ew0I-6b9gB:
undetectable		 6ew0I-6b9gB:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bq1 PHOSPHATIDYLINOSITOL
4-KINASE III ALPHA
(PI4KA)

(Homo sapiens) 		no annotation 6 LEU A1621
LEU A2040
ALA A1649
SER A1280
LEU A1642
LEU A1683
 None
 1.45A 6ew0I-6bq1A:
undetectable		 6ew0I-6bq1A:
0.00