SIMILAR PATTERNS OF AMINO ACIDS FOR 6EW0_G_TA1G501_2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1biy LACTOFERRIN

(Bubalus bubalis) 		PF00405
(Transferrin) 		4 LEU A 451
LEU A 589
THR A 577
ARG A 566
 None
 0.92A 6ew0G-1biyA:
undetectable		 6ew0G-1biyA:
7.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gkr NON-ATP DEPENDENT
L-SELECTIVE
HYDANTOINASE

(Paenarthrobacter
aurescens) 		PF01979
(Amidohydro_1) 		4 LEU A 360
LEU A 392
THR A 347
ARG A 406
 None
 1.11A 6ew0G-1gkrA:
undetectable		 6ew0G-1gkrA:
11.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1htj KIAA0380

(Homo sapiens) 		PF09128
(RGS-like) 		4 LEU F 324
THR F 478
PRO F 374
ARG F 376
 None
 1.08A 6ew0G-1htjF:
undetectable		 6ew0G-1htjF:
15.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i7q ANTHRANILATE
SYNTHASE

(Serratia
marcescens) 		PF00425
(Chorismate_bind)
PF04715
(Anth_synt_I_N) 		4 LEU A 127
LEU A 154
THR A  67
ARG A 169
 None
 0.98A 6ew0G-1i7qA:
0.0		 6ew0G-1i7qA:
10.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iq0 ARGINYL-TRNA
SYNTHETASE

(Thermus
thermophilus) 		PF00750
(tRNA-synt_1d)
PF03485
(Arg_tRNA_synt_N)
PF05746
(DALR_1) 		4 LEU A 160
THR A 152
PRO A 337
ARG A 322
 None
 0.95A 6ew0G-1iq0A:
0.3		 6ew0G-1iq0A:
9.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jct GLUCARATE
DEHYDRATASE

(Escherichia
coli) 		PF13378
(MR_MLE_C) 		4 LEU A 378
THR A  37
PRO A 163
ARG A 157
 None
 0.97A 6ew0G-1jctA:
3.1		 6ew0G-1jctA:
11.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kgs DNA BINDING RESPONSE
REGULATOR D

(Thermotoga
maritima) 		PF00072
(Response_reg)
PF00486
(Trans_reg_C) 		4 LEU A 110
LEU A  14
THR A  81
PRO A  57
 None
 1.06A 6ew0G-1kgsA:
0.2		 6ew0G-1kgsA:
16.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lu4 SOLUBLE SECRETED
ANTIGEN MPT53

(Mycobacterium
tuberculosis) 		PF00578
(AhpC-TSA) 		4 LEU A1079
LEU A1012
THR A1033
ARG A1094
 None
 1.03A 6ew0G-1lu4A:
1.8		 6ew0G-1lu4A:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n7d LOW-DENSITY
LIPOPROTEIN RECEPTOR

(Homo sapiens) 		PF00057
(Ldl_recept_a)
PF00058
(Ldl_recept_b)
PF07645
(EGF_CA)
PF14670
(FXa_inhibition) 		4 LEU A 661
THR A 489
PRO A 498
ARG A 499
 None
 0.93A 6ew0G-1n7dA:
undetectable		 6ew0G-1n7dA:
8.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p43 ENOLASE 1

(Saccharomyces
cerevisiae) 		PF00113
(Enolase_C)
PF03952
(Enolase_N) 		4 LEU A 115
LEU A 133
THR A 381
PRO A 147
 None
 1.06A 6ew0G-1p43A:
0.4		 6ew0G-1p43A:
12.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q0z ACLACINOMYCIN
METHYLESTERASE

(Streptomyces
purpurascens) 		PF00561
(Abhydrolase_1) 		4 LEU A  88
LEU A 119
ARG A 267
ARG A 295
 None
 1.08A 6ew0G-1q0zA:
2.8		 6ew0G-1q0zA:
14.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qi9 PROTEIN (VANADIUM
BROMOPEROXIDASE)

(Ascophyllum
nodosum) 		no annotation 4 LEU A 380
LEU A 146
THR A 397
ARG A 349
 None
None
None
VO4  A 600 (-2.7A)
 1.05A 6ew0G-1qi9A:
undetectable		 6ew0G-1qi9A:
9.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qzg PROTECTION OF
TELOMERES PROTEIN 1

(Schizosaccharomyces
pombe) 		PF02765
(POT1) 		4 LEU A  45
LEU A  87
THR A 111
ARG A 116
 None
 1.08A 6ew0G-1qzgA:
undetectable		 6ew0G-1qzgA:
14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tjr BX1

(Zea mays) 		PF00290
(Trp_syntA) 		4 LEU A 177
LEU A 135
ARG A 155
ARG A 333
 None
 0.93A 6ew0G-1tjrA:
undetectable		 6ew0G-1tjrA:
13.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vkz PHOSPHORIBOSYLAMINE-
-GLYCINE LIGASE

(Thermotoga
maritima) 		PF01071
(GARS_A)
PF02843
(GARS_C)
PF02844
(GARS_N) 		4 LEU A 338
LEU A 321
PRO A 281
ARG A  14
 None
 0.89A 6ew0G-1vkzA:
1.4		 6ew0G-1vkzA:
12.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vzo RIBOSOMAL PROTEIN S6
KINASE ALPHA 5

(Homo sapiens) 		PF00069
(Pkinase) 		4 LEU A 105
LEU A 129
THR A  87
ARG A 209
 None
 1.06A 6ew0G-1vzoA:
undetectable		 6ew0G-1vzoA:
13.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wn9 THE HYPOTHETICAL
PROTEIN (TT1805)

(Thermus
thermophilus) 		PF11432
(DUF3197) 		4 LEU A 102
LEU A  58
THR A  35
ARG A  88
 None
 1.07A 6ew0G-1wn9A:
undetectable		 6ew0G-1wn9A:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wwl MONOCYTE
DIFFERENTIATION
ANTIGEN CD14

(Mus musculus) 		no annotation 4 LEU A 128
LEU A  91
THR A  76
ARG A  81
 None
 1.03A 6ew0G-1wwlA:
undetectable		 6ew0G-1wwlA:
12.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wyt GLYCINE
DEHYDROGENASE
SUBUNIT 2
(P-PROTEIN)

(Thermus
thermophilus) 		PF02347
(GDC-P) 		4 LEU B  71
THR B  67
ARG B  60
PRO B 453
 None
 1.03A 6ew0G-1wytB:
2.6		 6ew0G-1wytB:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xv9 ORPHAN NUCLEAR
RECEPTOR NR1I3

(Homo sapiens) 		PF00104
(Hormone_recep) 		4 LEU B 242
LEU B 206
THR B 225
ARG B 136
 None
 1.09A 6ew0G-1xv9B:
undetectable		 6ew0G-1xv9B:
15.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cge ATP-DEPENDENT
MOLECULAR CHAPERONE
HSP82

(Saccharomyces
cerevisiae) 		PF00183
(HSP90) 		4 LEU A 558
LEU A 651
THR A 612
PRO A 486
 None
 0.82A 6ew0G-2cgeA:
undetectable		 6ew0G-2cgeA:
12.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ch1 3-HYDROXYKYNURENINE
TRANSAMINASE

(Anopheles
gambiae) 		PF00266
(Aminotran_5) 		4 LEU A 176
LEU A 135
THR A 150
ARG A 311
 None
 1.11A 6ew0G-2ch1A:
undetectable		 6ew0G-2ch1A:
11.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d0o DIOL
DEHYDRATASE-REACTIVA
TING FACTOR LARGE
SUBUNIT
DIOL
DEHYDRATASE-REACTIVA
TING FACTOR SMALL
SUBUNIT

(Klebsiella
oxytoca) 		PF02288
(Dehydratase_MU)
PF08841
(DDR) 		4 LEU A 353
LEU A 450
ARG A 496
ARG B 112
 None
 0.99A 6ew0G-2d0oA:
undetectable		 6ew0G-2d0oA:
8.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gwc GLUTAMATE CYSTEINE
LIGASE

(Brassica juncea) 		PF04107
(GCS2) 		4 LEU A 476
LEU A 274
ARG A 433
ARG A 387
 None
None
None
BSC  A   2 (-2.6A)
 1.09A 6ew0G-2gwcA:
undetectable		 6ew0G-2gwcA:
11.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gwr DNA-BINDING RESPONSE
REGULATOR MTRA

(Mycobacterium
tuberculosis) 		PF00072
(Response_reg)
PF00486
(Trans_reg_C) 		4 LEU A 112
LEU A  17
THR A  83
PRO A  60
 None
 1.04A 6ew0G-2gwrA:
undetectable		 6ew0G-2gwrA:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hnh DNA POLYMERASE III
ALPHA SUBUNIT

(Escherichia
coli) 		PF02811
(PHP)
PF07733
(DNA_pol3_alpha)
PF14579
(HHH_6) 		4 LEU A 249
LEU A 182
THR A 199
ARG A 141
 None
 1.10A 6ew0G-2hnhA:
undetectable		 6ew0G-2hnhA:
6.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mcp IGA-KAPPA MCPC603
FAB (HEAVY CHAIN)

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 LEU H  18
THR H 117
PRO H 128
ARG H 126
 None
 1.05A 6ew0G-2mcpH:
undetectable		 6ew0G-2mcpH:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nzx ALPHA1,3-FUCOSYLTRAN
SFERASE

(Helicobacter
pylori) 		PF00852
(Glyco_transf_10) 		4 LEU A  69
LEU A  51
THR A 337
ARG A 121
 None
 1.10A 6ew0G-2nzxA:
undetectable		 6ew0G-2nzxA:
11.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o1v ENDOPLASMIN

(Canis lupus) 		PF00183
(HSP90)
PF02518
(HATPase_c) 		4 LEU A 619
THR A 684
ARG A 724
PRO A 553
 None
 1.05A 6ew0G-2o1vA:
undetectable		 6ew0G-2o1vA:
9.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qqk NEUROPILIN-2

(Homo sapiens) 		PF00431
(CUB)
PF00754
(F5_F8_type_C) 		4 LEU A 441
LEU A 590
THR A 337
PRO A 271
 None
 0.95A 6ew0G-2qqkA:
undetectable		 6ew0G-2qqkA:
10.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qts ACID-SENSING ION
CHANNEL

(Gallus gallus) 		PF00858
(ASC) 		4 LEU A 219
LEU A 223
THR A  92
ARG A 100
 None
 1.00A 6ew0G-2qtsA:
undetectable		 6ew0G-2qtsA:
9.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r0l HEPATOCYTE GROWTH
FACTOR ACTIVATOR

(Homo sapiens) 		PF00089
(Trypsin)
no annotation 		4 LEU A 105
LEU A 123
THR A  49
PRO B 388
 None
 1.02A 6ew0G-2r0lA:
undetectable		 6ew0G-2r0lA:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r0l HEPATOCYTE GROWTH
FACTOR ACTIVATOR

(Homo sapiens) 		PF00089
(Trypsin)
no annotation 		4 LEU A 123
THR A  49
ARG B 395
ARG B 390
 None
 1.08A 6ew0G-2r0lA:
undetectable		 6ew0G-2r0lA:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rkv TRICHOTHECENE
3-O-ACETYLTRANSFERAS
E

(Fusarium
graminearum) 		PF02458
(Transferase) 		4 LEU A 171
LEU A 392
THR A 151
ARG A  90
 None
 0.82A 6ew0G-2rkvA:
undetectable		 6ew0G-2rkvA:
11.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xnd ATP SYNTHASE SUBUNIT
DELTA, MITOCHONDRIAL
ATP SYNTHASE SUBUNIT
EPSILON,
MITOCHONDRIAL

(Bos taurus) 		PF02823
(ATP-synt_DE_N)
PF04627
(ATP-synt_Eps) 		4 LEU I  26
LEU H 141
THR H  99
PRO H  39
 None
 1.06A 6ew0G-2xndI:
undetectable		 6ew0G-2xndI:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y9y ISWI ONE COMPLEX
PROTEIN 3

(Saccharomyces
cerevisiae) 		PF15612
(WHIM1) 		4 LEU B 530
LEU B 535
THR B 148
ARG B 542
 None
 1.05A 6ew0G-2y9yB:
undetectable		 6ew0G-2y9yB:
8.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ycb CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR

(Methanothermobacter
thermautotrophicus) 		PF07521
(RMMBL)
PF10996
(Beta-Casp)
PF16661
(Lactamase_B_6)
PF17214
(KH_7) 		4 LEU A 196
LEU A 338
THR A 350
PRO A 594
 None
 0.91A 6ew0G-2ycbA:
undetectable		 6ew0G-2ycbA:
9.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yx0 RADICAL SAM ENZYME

(Pyrococcus
horikoshii) 		PF04055
(Radical_SAM)
PF08608
(Wyosine_form) 		4 LEU A 231
LEU A 198
THR A 180
PRO A  76
 None
 1.09A 6ew0G-2yx0A:
3.0		 6ew0G-2yx0A:
12.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z9v ASPARTATE
AMINOTRANSFERASE

(Mesorhizobium
loti) 		PF00266
(Aminotran_5) 		4 LEU A 292
LEU A 320
THR A 363
ARG A   3
 None
 1.10A 6ew0G-2z9vA:
undetectable		 6ew0G-2z9vA:
12.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zbw THIOREDOXIN
REDUCTASE

(Thermus
thermophilus) 		PF07992
(Pyr_redox_2) 		4 LEU A 237
LEU A 156
THR A 210
ARG A 205
 None
 0.94A 6ew0G-2zbwA:
undetectable		 6ew0G-2zbwA:
12.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3af5 PUTATIVE
UNCHARACTERIZED
PROTEIN PH1404

(Pyrococcus
horikoshii) 		PF07521
(RMMBL)
PF10996
(Beta-Casp)
PF16661
(Lactamase_B_6)
PF17214
(KH_7) 		4 LEU A 205
LEU A 353
THR A 365
PRO A 609
 None
 1.00A 6ew0G-3af5A:
undetectable		 6ew0G-3af5A:
8.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aov PUTATIVE
UNCHARACTERIZED
PROTEIN PH0207

(Pyrococcus
horikoshii) 		PF00155
(Aminotran_1_2) 		4 LEU A 318
LEU A 111
THR A 266
PRO A 204
 None
None
PLP  A 429 (-3.1A)
None
 1.06A 6ew0G-3aovA:
undetectable		 6ew0G-3aovA:
12.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cai POSSIBLE
AMINOTRANSFERASE

(Mycobacterium
tuberculosis) 		PF00266
(Aminotran_5) 		4 LEU A 394
LEU A 307
THR A 375
PRO A 323
 None
 0.92A 6ew0G-3caiA:
undetectable		 6ew0G-3caiA:
11.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e9d ZGC:56074

(Danio rerio) 		PF00300
(His_Phos_1) 		4 LEU A 139
LEU A 194
THR A   7
PRO A 161
 None
 0.99A 6ew0G-3e9dA:
undetectable		 6ew0G-3e9dA:
15.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g87 MALONYL COA-ACYL
CARRIER PROTEIN
TRANSACYLASE

(Burkholderia
pseudomallei) 		PF00698
(Acyl_transf_1) 		4 LEU A  32
LEU A 100
THR A  73
PRO A  85
 None
 1.06A 6ew0G-3g87A:
undetectable		 6ew0G-3g87A:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gl5 PUTATIVE DSBA
OXIDOREDUCTASE
SCO1869

(Streptomyces
coelicolor) 		PF01323
(DSBA) 		4 LEU A 157
LEU A 117
THR A  98
ARG A  89
 None
 1.08A 6ew0G-3gl5A:
undetectable		 6ew0G-3gl5A:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h5q PYRIMIDINE-NUCLEOSID
E PHOSPHORYLASE

(Staphylococcus
aureus) 		PF00591
(Glycos_transf_3)
PF02885
(Glycos_trans_3N)
PF07831
(PYNP_C) 		4 LEU A 260
LEU A 253
THR A  92
ARG A 112
 None
None
SO4  A 436 (-3.0A)
None
 1.09A 6ew0G-3h5qA:
undetectable		 6ew0G-3h5qA:
10.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hjc HEAT SHOCK PROTEIN
83-1

(Leishmania
major) 		PF00183
(HSP90) 		4 LEU A 287
LEU A 379
THR A 341
PRO A 214
 None
 1.02A 6ew0G-3hjcA:
undetectable		 6ew0G-3hjcA:
10.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hrd NICOTINATE
DEHYDROGENASE LARGE
MOLYBDOPTERIN
SUBUNIT
NICOTINATE
DEHYDROGENASE MEDIUM
MOLYBDOPTERIN
SUBUNIT

(Eubacterium
barkeri) 		PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2) 		4 LEU B  91
THR B  18
PRO B 290
ARG A 351
 None
NIO  B5661 (-3.9A)
None
MCN  B 921 ( 4.0A)
 1.10A 6ew0G-3hrdB:
undetectable		 6ew0G-3hrdB:
14.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hrp UNCHARACTERIZED
PROTEIN

(Bacteroides
thetaiotaomicron) 		PF01833
(TIG) 		4 LEU A 254
THR A 216
PRO A 173
ARG A 176
 None
EDO  A  15 (-3.2A)
None
None
 1.03A 6ew0G-3hrpA:
undetectable		 6ew0G-3hrpA:
12.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3htz ALANYL-TRNA
SYNTHETASE

(Aquifex
aeolicus) 		PF01411
(tRNA-synt_2c) 		4 LEU A  68
THR A 277
ARG A 301
ARG A 267
 None
 1.01A 6ew0G-3htzA:
undetectable		 6ew0G-3htzA:
14.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iz3 STRUCTURAL PROTEIN
VP1
VIRAL STRUCTURAL
PROTEIN 5

(Cypovirus 1) 		no annotation 4 LEU D  35
LEU D 189
ARG B1053
ARG D 265
 None
 1.01A 6ew0G-3iz3D:
undetectable		 6ew0G-3iz3D:
14.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j2s COAGULATION FACTOR
VIII LIGHT CHAIN

(Homo sapiens) 		PF00754
(F5_F8_type_C)
PF07731
(Cu-oxidase_2) 		4 LEU B2306
LEU B2178
THR B2237
ARG B2147
 None
 1.09A 6ew0G-3j2sB:
undetectable		 6ew0G-3j2sB:
8.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3keb PROBABLE THIOL
PEROXIDASE

(Chromobacterium
violaceum) 		no annotation 4 LEU A  68
LEU A  94
THR A  53
ARG A 113
 None
 1.03A 6ew0G-3kebA:
undetectable		 6ew0G-3kebA:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l12 PUTATIVE
GLYCEROPHOSPHORYL
DIESTER
PHOSPHODIESTERASE

(Ruegeria
pomeroyi) 		PF03009
(GDPD) 		4 LEU A 207
LEU A 146
THR A 272
PRO A 297
 UNL  A 317 ( 4.5A)
None
None
None
 1.05A 6ew0G-3l12A:
undetectable		 6ew0G-3l12A:
13.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l8m PROBABLE THIAMINE
PYROPHOSPHOKINASE

(Staphylococcus
saprophyticus) 		PF04263
(TPK_catalytic)
PF04265
(TPK_B1_binding) 		4 LEU A  78
LEU A 113
THR A  99
ARG A 208
 None
 0.95A 6ew0G-3l8mA:
undetectable		 6ew0G-3l8mA:
15.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ldt OUTER MEMBRANE
PROTEIN, OMPA FAMILY
PROTEIN

(Legionella
pneumophila) 		PF00691
(OmpA) 		4 LEU A 155
LEU A 109
THR A 124
ARG A 227
 None
 1.09A 6ew0G-3ldtA:
undetectable		 6ew0G-3ldtA:
17.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lop SUBSTRATE BINDING
PERIPLASMIC PROTEIN

(Ralstonia
solanacearum) 		PF13458
(Peripla_BP_6) 		4 LEU A 119
THR A 109
ARG A 339
PRO A 104
 None
 1.01A 6ew0G-3lopA:
undetectable		 6ew0G-3lopA:
12.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lxq UNCHARACTERIZED
PROTEIN VP1736

(Vibrio
parahaemolyticus) 		PF00884
(Sulfatase) 		4 LEU A 287
THR A 548
PRO A 344
ARG A 334
 None
None
None
CL  A   1 (-4.5A)
 1.07A 6ew0G-3lxqA:
undetectable		 6ew0G-3lxqA:
11.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mzs CHOLESTEROL
SIDE-CHAIN CLEAVAGE
ENZYME

(Bos taurus) 		PF00067
(p450) 		4 LEU A 300
THR A 434
PRO A 398
ARG A 400
 None
 0.96A 6ew0G-3mzsA:
undetectable		 6ew0G-3mzsA:
12.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n0g ISOPRENE SYNTHASE

(Populus tremula
x Populus alba) 		PF01397
(Terpene_synth)
PF03936
(Terpene_synth_C) 		4 LEU A 386
LEU A 450
THR A 342
ARG A 331
 None
 1.01A 6ew0G-3n0gA:
undetectable		 6ew0G-3n0gA:
9.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3na0 CHOLESTEROL
SIDE-CHAIN CLEAVAGE
ENZYME,
MITOCHONDRIAL

(Homo sapiens) 		PF00067
(p450) 		4 LEU A 339
THR A 473
PRO A 437
ARG A 439
 None
 0.98A 6ew0G-3na0A:
undetectable		 6ew0G-3na0A:
11.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nhz TWO COMPONENT SYSTEM
TRANSCRIPTIONAL
REGULATOR MTRA

(Mycobacterium
tuberculosis) 		PF00072
(Response_reg) 		4 LEU A 112
LEU A  17
THR A  83
PRO A  60
 None
 0.95A 6ew0G-3nhzA:
undetectable		 6ew0G-3nhzA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nwr A RUBISCO-LIKE
PROTEIN

(Paraburkholderia
fungorum) 		PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N) 		4 LEU A 307
LEU A  15
THR A 109
ARG A  58
 None
 1.06A 6ew0G-3nwrA:
undetectable		 6ew0G-3nwrA:
11.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nxl GLUCARATE
DEHYDRATASE

(Burkholderia
lata) 		PF13378
(MR_MLE_C) 		4 LEU A 398
THR A  41
PRO A 183
ARG A 177
 None
 1.08A 6ew0G-3nxlA:
2.3		 6ew0G-3nxlA:
10.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ohu TRANSCRIPTION
REGULATOR PROTEIN
BACH2

(Homo sapiens) 		PF00651
(BTB) 		4 LEU A  55
LEU A  78
THR A  40
ARG A  45
 None
 1.07A 6ew0G-3ohuA:
undetectable		 6ew0G-3ohuA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pls MACROPHAGE-STIMULATI
NG PROTEIN RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LEU A1300
LEU A1306
THR A1254
ARG A1245
 None
 1.10A 6ew0G-3plsA:
undetectable		 6ew0G-3plsA:
15.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r3s OXIDOREDUCTASE

(Salmonella
enterica) 		PF13561
(adh_short_C2) 		4 LEU A 118
LEU A 129
THR A 168
ARG A 223
 None
 1.09A 6ew0G-3r3sA:
undetectable		 6ew0G-3r3sA:
13.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rpx COMPLEMENT COMPONENT
1 Q
SUBCOMPONENT-BINDING
PROTEIN

(Homo sapiens) 		PF02330
(MAM33) 		4 LEU A 111
LEU A 256
THR A 130
ARG A 207
 None
 1.09A 6ew0G-3rpxA:
undetectable		 6ew0G-3rpxA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s5n 4-HYDROXY-2-OXOGLUTA
RATE ALDOLASE,
MITOCHONDRIAL

(Homo sapiens) 		PF00701
(DHDPS) 		4 LEU A 288
LEU A  64
THR A  44
ARG A  97
 None
 1.08A 6ew0G-3s5nA:
undetectable		 6ew0G-3s5nA:
14.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3skd PUTATIVE
UNCHARACTERIZED
PROTEIN TTHB187

(Thermus
thermophilus) 		no annotation 4 LEU A 230
LEU A 176
THR A  28
ARG A 196
 None
 1.08A 6ew0G-3skdA:
undetectable		 6ew0G-3skdA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tch PERIPLASMIC
OLIGOPEPTIDE-BINDING
PROTEIN

(Escherichia
coli) 		PF00496
(SBP_bac_5) 		4 LEU A 499
LEU A 353
THR A 450
PRO A 529
 None
 1.04A 6ew0G-3tchA:
undetectable		 6ew0G-3tchA:
9.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u9s METHYLCROTONYL-COA
CARBOXYLASE,
ALPHA-SUBUNIT

(Pseudomonas
aeruginosa) 		PF00289
(Biotin_carb_N)
PF00364
(Biotin_lipoyl)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		4 LEU A 612
THR A 458
PRO A 391
ARG A 464
 None
 1.08A 6ew0G-3u9sA:
undetectable		 6ew0G-3u9sA:
9.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w9s OMPR FAMILY RESPONSE
REGULATOR IN
TWO-COMPONENT
REGULATORY SYSTEM
WITH BASS

(Klebsiella
pneumoniae) 		PF00072
(Response_reg) 		4 LEU A 108
LEU A  12
THR A  79
PRO A  55
 None
None
BEF  A 201 (-3.7A)
None
 1.01A 6ew0G-3w9sA:
undetectable		 6ew0G-3w9sA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wrc GALLATE DIOXYGENASE

(Sphingomonas
paucimobilis) 		PF02900
(LigB)
PF07746
(LigA) 		4 LEU A  99
LEU A 169
THR A  52
ARG A 247
 None
 0.85A 6ew0G-3wrcA:
undetectable		 6ew0G-3wrcA:
10.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bg2 PATF

(Prochloron
didemni) 		no annotation 4 LEU A  87
LEU A 181
THR A 121
ARG A 239
 None
 1.04A 6ew0G-4bg2A:
undetectable		 6ew0G-4bg2A:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bqi ALPHA-GLUCAN
PHOSPHORYLASE 2,
CYTOSOLIC

(Arabidopsis
thaliana) 		PF00343
(Phosphorylase) 		4 LEU A 309
THR A 345
ARG A 400
ARG A 411
 None
None
MLR  A 951 (-2.9A)
MLR  A 951 (-4.1A)
 1.01A 6ew0G-4bqiA:
undetectable		 6ew0G-4bqiA:
7.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4czb NA(+)/H(+)
ANTIPORTER 1

(Methanocaldococcus
jannaschii) 		PF00999
(Na_H_Exchanger) 		4 LEU A 187
LEU A  98
THR A 168
ARG A 320
 None
 1.08A 6ew0G-4czbA:
undetectable		 6ew0G-4czbA:
11.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fdd TRANSPORTIN-1

(Homo sapiens) 		PF03810
(IBN_N)
PF13513
(HEAT_EZ) 		4 LEU A 293
LEU A 304
THR A 282
ARG A 232
 None
 1.05A 6ew0G-4fddA:
1.9		 6ew0G-4fddA:
6.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fim LACTOTRANSFERRIN

(Bos taurus) 		PF00405
(Transferrin) 		4 LEU A 451
LEU A 589
THR A 577
ARG A 566
 GOL  A 712 ( 4.7A)
None
None
NAG  A 710 ( 4.7A)
 1.02A 6ew0G-4fimA:
undetectable		 6ew0G-4fimA:
12.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g2t SSFS6

(Streptomyces
sp. SF2575) 		PF00201
(UDPGT)
PF06722
(DUF1205) 		4 LEU A 237
LEU A 245
THR A 218
PRO A 307
 None
 1.06A 6ew0G-4g2tA:
undetectable		 6ew0G-4g2tA:
11.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g6t TYPE III CHAPERONE
PROTEIN SHCA
TYPE III EFFECTOR
HOPA1

(Pseudomonas
syringae group
genomosp. 3) 		PF05932
(CesT)
no annotation 		4 LEU B  30
LEU A  42
THR A 107
ARG A  50
 None
 1.01A 6ew0G-4g6tB:
undetectable		 6ew0G-4g6tB:
25.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4glp MONOCYTE
DIFFERENTIATION
ANTIGEN CD14

(Homo sapiens) 		PF13516
(LRR_6) 		4 LEU A 164
LEU A 172
THR A 122
ARG A 117
 None
 1.06A 6ew0G-4glpA:
undetectable		 6ew0G-4glpA:
12.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gyp GLUCARATE
DEHYDRATASE-RELATED
PROTEIN

(Escherichia
coli) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 LEU C 377
THR C  36
PRO C 162
ARG C 156
 None
 1.04A 6ew0G-4gypC:
undetectable		 6ew0G-4gypC:
10.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hn8 D-GLUCARATE
DEHYDRATASE

(Pseudomonas
mendocina) 		PF13378
(MR_MLE_C) 		4 LEU A 395
THR A  39
PRO A 180
ARG A 174
 None
 1.05A 6ew0G-4hn8A:
undetectable		 6ew0G-4hn8A:
9.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hst GLUTARYL-7-AMINOCEPH
ALOSPORANIC ACID
ACYLASE ALPHA CHAIN
GLUTARYL-7-AMINOCEPH
ALOSPORANIC ACID
ACYLASE BETA CHAIN

(Pseudomonas) 		PF01804
(Penicil_amidase) 		4 LEU B 399
LEU B 390
THR B 344
ARG A 190
 None
 1.01A 6ew0G-4hstB:
undetectable		 6ew0G-4hstB:
11.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hyr GLUCARATE
DEHYDRATASE

(Acidaminococcus
intestini) 		PF13378
(MR_MLE_C) 		4 LEU A 374
THR A  32
PRO A 159
ARG A 153
 None
 0.99A 6ew0G-4hyrA:
undetectable		 6ew0G-4hyrA:
11.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i0k CD276 ANTIGEN

(Mus musculus) 		PF07686
(V-set)
PF13927
(Ig_3) 		4 LEU A 212
LEU A 208
THR A 217
PRO A 145
 None
None
SO4  A 307 (-4.4A)
None
 0.92A 6ew0G-4i0kA:
undetectable		 6ew0G-4i0kA:
16.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4il1 CALMODULIN,
CALCINEURIN SUBUNIT
B TYPE 1,
SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2B
CATALYTIC SUBUNIT
ALPHA ISOFORM

(Rattus
norvegicus) 		PF00149
(Metallophos)
PF13499
(EF-hand_7) 		4 LEU A 466
THR A 476
PRO A 374
ARG A 375
 None
 1.08A 6ew0G-4il1A:
undetectable		 6ew0G-4il1A:
7.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kbx UNCHARACTERIZED
PROTEIN YHFX

(Escherichia
coli) 		PF01168
(Ala_racemase_N) 		4 LEU A  45
LEU A  58
THR A 260
ARG A  65
 None
 1.05A 6ew0G-4kbxA:
undetectable		 6ew0G-4kbxA:
13.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ld7 DIMETHYLALLYL
TRYPTOPHAN SYNTHASE

(Aspergillus
fischeri) 		PF11991
(Trp_DMAT) 		4 LEU A 360
LEU A 318
THR A 424
PRO A 354
 NA  A 502 (-4.5A)
None
None
None
 1.10A 6ew0G-4ld7A:
undetectable		 6ew0G-4ld7A:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o6x ANKYRIN-3

(Homo sapiens) 		PF00531
(Death) 		4 LEU A  26
LEU A  15
THR A  69
ARG A   3
 None
 1.07A 6ew0G-4o6xA:
undetectable		 6ew0G-4o6xA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p69 ISOCITRATE
DEHYDROGENASE
KINASE/PHOSPHATASE

(Escherichia
coli) 		PF06315
(AceK) 		5 LEU A 213
LEU A 153
THR A 181
ARG A 171
ARG A 568
 None
 1.43A 6ew0G-4p69A:
undetectable		 6ew0G-4p69A:
9.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pag PERIPLASMIC BINDING
PROTEIN

(Sulfurospirillum
deleyianum) 		PF01497
(Peripla_BP_2) 		4 LEU A 340
LEU A 295
PRO A 288
ARG A 287
 None
 0.90A 6ew0G-4pagA:
undetectable		 6ew0G-4pagA:
13.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ptz FMN REDUCTASE SSUE

(Escherichia
coli) 		no annotation 4 LEU C  63
LEU C  87
THR C   4
PRO C  74
 None
None
None
FMN  C 201 (-4.1A)
 1.01A 6ew0G-4ptzC:
undetectable		 6ew0G-4ptzC:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r0b GLYCODELIN

(Homo sapiens) 		PF00061
(Lipocalin) 		4 LEU A  15
LEU A 122
THR A  93
ARG A 138
 None
 1.03A 6ew0G-4r0bA:
undetectable		 6ew0G-4r0bA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v2x ENDO-BETA-1,4-GLUCAN
ASE (CELLULASE B)

(Bacillus
halodurans) 		PF00150
(Cellulase)
PF03442
(CBM_X2) 		4 LEU A 462
LEU A 483
THR A 538
ARG A 265
 None
 1.10A 6ew0G-4v2xA:
undetectable		 6ew0G-4v2xA:
9.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yeb FIBRONECTIN LEUCINE
RICH TRANSMEMBRANE
PROTEIN 3

(Mus musculus) 		PF13855
(LRR_8) 		4 LEU B 195
LEU B 232
THR B 189
ARG B 163
 None
 1.01A 6ew0G-4yebB:
undetectable		 6ew0G-4yebB:
11.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ysw XANTHINE
DEHYDROGENASE/OXIDAS
E

(Rattus
norvegicus) 		PF00111
(Fer2)
PF00941
(FAD_binding_5)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2)
PF03450
(CO_deh_flav_C) 		4 LEU A 493
LEU A 466
THR A 462
ARG A 383
 None
 0.96A 6ew0G-4yswA:
undetectable		 6ew0G-4yswA:
5.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zqv CDII IMMUNITY
PROTEIN

(Yersinia
kristensenii) 		PF07262
(CdiI) 		4 LEU A 156
LEU A  58
THR A 118
ARG A  29
 None
 1.09A 6ew0G-4zqvA:
undetectable		 6ew0G-4zqvA:
18.42