SIMILAR PATTERNS OF AMINO ACIDS FOR 6EW0_G_TA1G501_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1brt BROMOPEROXIDASE A2

(Kitasatospora
aureofaciens) 		PF00561
(Abhydrolase_1) 		5 VAL A 104
LEU A  46
ALA A 120
PHE A 274
LEU A 275
 None
 1.19A 6ew0G-1brtA:
4.1		 6ew0G-1brtA:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h2b ALCOHOL
DEHYDROGENASE

(Aeropyrum
pernix) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 VAL A  33
ASP A  32
GLU A  31
ARG A  47
LEU A 336
 None
 1.19A 6ew0G-1h2bA:
3.2		 6ew0G-1h2bA:
12.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h8l CARBOXYPEPTIDASE
GP180 RESIDUES
503-882

(Lophonetta
specularioides) 		PF00246
(Peptidase_M14)
PF13620
(CarboxypepD_reg) 		5 VAL A 368
ASP A 369
LEU A 176
LEU A 213
GLN A 297
 None
 1.12A 6ew0G-1h8lA:
undetectable		 6ew0G-1h8lA:
11.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hkk CHITOTRIOSIDASE-1

(Homo sapiens) 		PF00704
(Glyco_hydro_18) 		5 VAL A 243
ASP A 244
LEU A 385
SER A 226
LEU A 381
 None
 1.18A 6ew0G-1hkkA:
undetectable		 6ew0G-1hkkA:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jxn ANTI-H(O) LECTIN I

(Ulex europaeus) 		PF00139
(Lectin_legB) 		5 VAL A 124
ASP A 146
PHE A  68
ARG A  50
LEU A 206
 None
 1.20A 6ew0G-1jxnA:
undetectable		 6ew0G-1jxnA:
15.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qgu PROTEIN (NITROGENASE
MOLYBDENUM IRON
PROTEIN)

(Klebsiella
pneumoniae) 		PF00148
(Oxidored_nitro) 		5 GLU A 425
LEU A  11
ALA A 402
PHE A 399
LEU A 397
 None
 1.18A 6ew0G-1qguA:
undetectable		 6ew0G-1qguA:
11.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t6p PHENYLALANINE
AMMONIA-LYASE

(Rhodotorula
toruloides) 		PF00221
(Lyase_aromatic) 		5 LEU A 532
ALA A 701
SER A 704
LEU A 528
LEU A 711
 None
 1.13A 6ew0G-1t6pA:
undetectable		 6ew0G-1t6pA:
7.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u0u DIHYDROPINOSYLVIN
SYNTHASE

(Pinus
sylvestris) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		5 VAL A 105
LEU A 153
ALA A 109
LEU A 190
ARG A 159
 None
 1.21A 6ew0G-1u0uA:
undetectable		 6ew0G-1u0uA:
12.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vf8 SECRETORY PROTEIN

(Mus musculus) 		PF00704
(Glyco_hydro_18) 		5 VAL A 222
ASP A 223
LEU A 366
SER A 205
LEU A 362
 None
 1.18A 6ew0G-1vf8A:
undetectable		 6ew0G-1vf8A:
12.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w8o BACTERIAL SIALIDASE

(Micromonospora
viridifaciens) 		PF00754
(F5_F8_type_C)
PF10633
(NPCBM_assoc)
PF13088
(BNR_2) 		5 GLU A 644
ALA A 612
PHE A 603
ARG A 623
LEU A 641
 None
 1.18A 6ew0G-1w8oA:
undetectable		 6ew0G-1w8oA:
9.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wb0 CHITOTRIOSIDASE 1

(Homo sapiens) 		PF00704
(Glyco_hydro_18) 		5 VAL A 243
ASP A 244
LEU A 387
SER A 226
LEU A 383
 None
 1.16A 6ew0G-1wb0A:
undetectable		 6ew0G-1wb0A:
11.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xa6 BETA2-CHIMAERIN

(Homo sapiens) 		PF00017
(SH2)
PF00130
(C1_1)
PF00620
(RhoGAP) 		5 VAL A 411
LEU A 401
PHE A 429
LEU A 433
LEU A 350
 None
 1.19A 6ew0G-1xa6A:
undetectable		 6ew0G-1xa6A:
11.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y4u CHAPERONE PROTEIN
HTPG

(Escherichia
coli) 		PF00183
(HSP90)
PF02518
(HATPase_c) 		5 GLU A 273
LEU A 278
SER A 328
LEU A 352
GLN A 358
 None
 1.21A 6ew0G-1y4uA:
undetectable		 6ew0G-1y4uA:
10.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zv5 IMMUNOGLOBULIN HEAVY
CHAIN ANTIBODY
VARIABLE DOMAIN

(Camelus
dromedarius) 		PF07686
(V-set) 		5 GLU A  89
SER A  63
PHE A  68
LEU A  81
LEU A  86
 None
 1.17A 6ew0G-1zv5A:
undetectable		 6ew0G-1zv5A:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a7m N-ACYL HOMOSERINE
LACTONE HYDROLASE

(Bacillus
thuringiensis) 		PF00753
(Lactamase_B) 		5 GLU A 127
LEU A 187
SER A 170
LEU A 220
GLN A 162
 None
 1.15A 6ew0G-2a7mA:
undetectable		 6ew0G-2a7mA:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cuk GLYCERATE
DEHYDROGENASE/GLYOXY
LATE REDUCTASE

(Thermus
thermophilus) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		5 ASP A  53
LEU A  22
ALA A  70
LEU A 301
LEU A  66
 None
 1.13A 6ew0G-2cukA:
undetectable		 6ew0G-2cukA:
15.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e5a LIPOYLTRANSFERASE 1

(Bos taurus) 		no annotation 5 VAL A 114
LEU A  39
ALA A 110
LEU A  89
ARG A  41
 None
 1.10A 6ew0G-2e5aA:
undetectable		 6ew0G-2e5aA:
15.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g2o MALONYL COA-ACYL
CARRIER PROTEIN
TRANSACYLASE

(Escherichia
coli) 		PF00698
(Acyl_transf_1) 		5 VAL A 100
LEU A  44
ALA A 110
GLN A  14
LEU A  93
 None
None
None
None
SO4  A1001 (-4.3A)
 1.12A 6ew0G-2g2oA:
undetectable		 6ew0G-2g2oA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g3k VACUOLAR PROTEIN
SORTING-ASSOCIATED
PROTEIN VPS28

(Saccharomyces
cerevisiae) 		PF03997
(VPS28) 		5 LEU A 181
ALA A 233
SER A 236
PHE A 160
LEU A 184
 None
 1.21A 6ew0G-2g3kA:
undetectable		 6ew0G-2g3kA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ip4 PHOSPHORIBOSYLAMINE-
-GLYCINE LIGASE

(Thermus
thermophilus) 		PF01071
(GARS_A)
PF02843
(GARS_C)
PF02844
(GARS_N) 		5 VAL A 305
PHE A 282
LEU A  15
GLN A  21
LEU A 294
 None
 1.19A 6ew0G-2ip4A:
undetectable		 6ew0G-2ip4A:
12.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iy8 PROTEIN PM0188

(Pasteurella
multocida) 		PF11477
(PM0188) 		5 LEU A 138
ALA A 192
PHE A 193
LEU A 136
LEU A 121
 None
 0.99A 6ew0G-2iy8A:
5.2		 6ew0G-2iy8A:
11.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nbr GAMMA-CRYSTALLIN C

(Homo sapiens) 		PF00030
(Crystall) 		5 ASP A 113
ALA A 163
LEU A 145
ARG A 167
LEU A 104
 None
 1.18A 6ew0G-2nbrA:
undetectable		 6ew0G-2nbrA:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2osa N-CHIMAERIN

(Homo sapiens) 		PF00620
(RhoGAP) 		5 VAL A 404
LEU A 394
PHE A 422
LEU A 426
LEU A 343
 None
 1.21A 6ew0G-2osaA:
undetectable		 6ew0G-2osaA:
16.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qx2 SEX PHEROMONE
STAPH-CAM373

(Staphylococcus
aureus) 		PF07537
(CamS) 		5 GLU A 227
LEU A  86
ALA A 225
PHE A 245
LEU A 232
 None
None
None
None
EDO  A 401 ( 4.9A)
 1.14A 6ew0G-2qx2A:
undetectable		 6ew0G-2qx2A:
11.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ybu ACIDIC MAMMALIAN
CHITINASE

(Homo sapiens) 		PF00704
(Glyco_hydro_18) 		5 VAL A 243
ASP A 244
LEU A 387
SER A 226
LEU A 383
 None
 1.16A 6ew0G-2ybuA:
undetectable		 6ew0G-2ybuA:
11.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zgd 3 REPEAT SYNTHETIC
ANKYRIN

(-) 		PF12796
(Ank_2) 		5 VAL A  40
ASP A  38
GLU A  39
LEU A 105
ALA A  32
 None
CD  A 413 ( 2.4A)
CD  A 410 ( 2.1A)
None
None
 1.08A 6ew0G-2zgdA:
undetectable		 6ew0G-2zgdA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3blx ISOCITRATE
DEHYDROGENASE [NAD]
SUBUNIT 2

(Saccharomyces
cerevisiae) 		PF00180
(Iso_dh) 		5 GLU B  54
LEU B  99
ALA B  73
SER B  76
LEU B 103
 None
 1.13A 6ew0G-3blxB:
undetectable		 6ew0G-3blxB:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cfx UPF0100 PROTEIN
MA_0280

(Methanosarcina
acetivorans) 		PF13531
(SBP_bac_11) 		5 LEU A  58
ALA A 119
PHE A 118
LEU A 315
ARG A  73
 None
 1.18A 6ew0G-3cfxA:
undetectable		 6ew0G-3cfxA:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cxl N-CHIMERIN

(Homo sapiens) 		PF00017
(SH2)
PF00130
(C1_1)
PF00620
(RhoGAP) 		5 VAL A 404
LEU A 394
PHE A 422
LEU A 426
LEU A 343
 None
 1.12A 6ew0G-3cxlA:
undetectable		 6ew0G-3cxlA:
11.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3foa TAIL SHEATH PROTEIN
GP18

(Escherichia
virus T4) 		PF04984
(Phage_sheath_1)
PF17481
(Phage_sheath_1N) 		5 VAL A 370
ASP A 369
ALA A  27
PHE A  71
LEU A  72
 None
 1.11A 6ew0G-3foaA:
undetectable		 6ew0G-3foaA:
8.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h2b SAM-DEPENDENT
METHYLTRANSFERASE

(Corynebacterium
glutamicum) 		PF13649
(Methyltransf_25) 		5 VAL A 105
ASP A 104
LEU A 222
PHE A 231
LEU A 226
 None
SAH  A 301 ( 4.4A)
None
None
None
 1.15A 6ew0G-3h2bA:
undetectable		 6ew0G-3h2bA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h9c METHIONYL-TRNA
SYNTHETASE

(Escherichia
coli) 		PF09334
(tRNA-synt_1g) 		5 LEU A 510
ALA A 393
PHE A 505
LEU A 506
LEU A 408
 None
 1.20A 6ew0G-3h9cA:
undetectable		 6ew0G-3h9cA:
10.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hjh TRANSCRIPTION-REPAIR
-COUPLING FACTOR

(Escherichia
coli) 		no annotation 5 GLU A 431
LEU A 441
ALA A  25
PHE A  62
LEU A 415
 None
 1.10A 6ew0G-3hjhA:
undetectable		 6ew0G-3hjhA:
9.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hjv MALONYL COA-ACYL
CARRIER PROTEIN
TRANSACYLASE

(Vibrio cholerae) 		PF00698
(Acyl_transf_1) 		5 VAL A 105
LEU A  49
ALA A 115
GLN A  19
LEU A  98
 None
None
None
CL  A 328 (-3.5A)
None
 1.13A 6ew0G-3hjvA:
undetectable		 6ew0G-3hjvA:
13.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hl1 FERRITIN LIKE
PROTEIN

(Caulobacter
vibrioides) 		PF12902
(Ferritin-like) 		5 VAL A 183
LEU A  10
ALA A 194
LEU A 150
GLN A  15
 None
 1.18A 6ew0G-3hl1A:
undetectable		 6ew0G-3hl1A:
14.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hva PROTEIN FIMX

(Pseudomonas
aeruginosa) 		PF00990
(GGDEF) 		5 VAL A 373
LEU A 275
PHE A 336
LEU A 342
ARG A 344
 None
 1.15A 6ew0G-3hvaA:
undetectable		 6ew0G-3hvaA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3im8 MALONYL ACYL CARRIER
PROTEIN TRANSACYLASE

(Streptococcus
pneumoniae) 		PF00698
(Acyl_transf_1) 		5 VAL A  98
LEU A  44
ALA A 108
GLN A  14
LEU A  91
 None
 1.08A 6ew0G-3im8A:
undetectable		 6ew0G-3im8A:
14.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iu1 GLYCYLPEPTIDE
N-TETRADECANOYLTRANS
FERASE 1

(Homo sapiens) 		PF01233
(NMT)
PF02799
(NMT_C) 		5 LEU A 329
ALA A 419
PHE A 450
LEU A 439
LEU A 398
 None
 1.11A 6ew0G-3iu1A:
undetectable		 6ew0G-3iu1A:
12.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j2n TAIL SHEATH PROTEIN
GP18

(Escherichia
virus T4) 		PF04984
(Phage_sheath_1)
PF17481
(Phage_sheath_1N)
PF17482
(Phage_sheath_1C) 		5 VAL U 370
ASP U 369
ALA U  27
PHE U  71
LEU U  72
 None
 1.11A 6ew0G-3j2nU:
3.7		 6ew0G-3j2nU:
9.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k8p DSL1

(Kluyveromyces
lactis) 		PF11989
(Dsl1_C) 		5 ALA C 434
PHE C 468
LEU C 499
ARG C 487
LEU C 482
 None
 1.18A 6ew0G-3k8pC:
undetectable		 6ew0G-3k8pC:
12.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lmd GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE

(Corynebacterium
glutamicum) 		PF00348
(polyprenyl_synt) 		5 VAL A 277
GLU A 273
LEU A 289
SER A 305
LEU A 258
 None
 1.07A 6ew0G-3lmdA:
undetectable		 6ew0G-3lmdA:
10.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oak TRANSCRIPTION FACTOR
IWS1

(Saccharomyces
cerevisiae) 		PF08711
(Med26) 		6 ASP A 163
GLU A 164
LEU A 225
LEU A 242
ARG A 222
LEU A 217
 None
 1.30A 6ew0G-3oakA:
undetectable		 6ew0G-3oakA:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3shu TIGHT JUNCTION
PROTEIN ZO-1

(Homo sapiens) 		PF00595
(PDZ) 		5 VAL A  35
ALA A  41
SER A  39
PHE A  12
LEU A  72
 None
 0.93A 6ew0G-3shuA:
undetectable		 6ew0G-3shuA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3shw TIGHT JUNCTION
PROTEIN ZO-1

(Homo sapiens) 		PF00595
(PDZ)
PF00625
(Guanylate_kin)
PF07653
(SH3_2) 		5 VAL A 450
ALA A 456
SER A 454
PHE A 427
LEU A 487
 None
 0.98A 6ew0G-3shwA:
undetectable		 6ew0G-3shwA:
11.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tsv TIGHT JUNCTION
PROTEIN ZO-1

(Homo sapiens) 		PF00595
(PDZ) 		5 VAL A 450
ALA A 456
SER A 454
PHE A 427
LEU A 487
 None
 1.03A 6ew0G-3tsvA:
undetectable		 6ew0G-3tsvA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w04 DWARF 88 ESTERASE

(Oryza sativa) 		PF12697
(Abhydrolase_6) 		5 ASP A 128
LEU A 169
ALA A 156
PHE A 164
LEU A 167
 None
 1.14A 6ew0G-3w04A:
3.7		 6ew0G-3w04A:
15.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zi1 GLYOXALASE
DOMAIN-CONTAINING
PROTEIN 4

(Homo sapiens) 		no annotation 5 ALA A 119
PHE A 125
LEU A  27
ARG A  24
LEU A  71
 None
 1.21A 6ew0G-3zi1A:
undetectable		 6ew0G-3zi1A:
14.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a11 DNA EXCISION REPAIR
PROTEIN ERCC-8

(Homo sapiens) 		PF00400
(WD40) 		5 LEU B 226
ALA B 191
SER B 146
LEU B 260
ARG B 270
 None
 1.21A 6ew0G-4a11B:
undetectable		 6ew0G-4a11B:
10.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c2x GLYCYLPEPTIDE
N-TETRADECANOYLTRANS
FERASE 2

(Homo sapiens) 		PF01233
(NMT)
PF02799
(NMT_C) 		5 LEU A 329
ALA A 419
PHE A 450
LEU A 439
LEU A 398
 None
 1.12A 6ew0G-4c2xA:
undetectable		 6ew0G-4c2xA:
11.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cp6 CHOLINE BINDING
PROTEIN PCPA

(Streptococcus
pneumoniae) 		PF13306
(LRR_5) 		5 LEU A 217
ALA A 182
PHE A 183
LEU A 192
LEU A 175
 None
 1.07A 6ew0G-4cp6A:
undetectable		 6ew0G-4cp6A:
11.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fmc RORF2

(Escherichia
coli) 		PF06872
(EspG) 		5 VAL A 340
LEU A 234
ALA A 290
SER A 342
PHE A 291
 None
 1.16A 6ew0G-4fmcA:
undetectable		 6ew0G-4fmcA:
12.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gfa SPINDLE ASSEMBLY
ABNORMAL PROTEIN 6

(Caenorhabditis
elegans) 		PF16531
(SAS-6_N) 		5 VAL A  85
ASP A  86
LEU A  98
PHE A 126
LEU A  69
 None
 1.18A 6ew0G-4gfaA:
undetectable		 6ew0G-4gfaA:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hes BETA-LACTAMASE CLASS
A-LIKE PROTEIN

(Veillonella
parvula) 		PF13354
(Beta-lactamase2) 		5 VAL A 224
ASP A 222
ALA A  55
SER A  53
GLN A  96
 None
 1.20A 6ew0G-4hesA:
undetectable		 6ew0G-4hesA:
13.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iq4 NON-HAEM
BROMOPEROXIDASE
BPO-A2, MATRIX
PROTEIN 1

(Influenza A
virus;
Kitasatospora
aureofaciens) 		PF00561
(Abhydrolase_1)
PF00598
(Flu_M1) 		5 VAL A 104
LEU A  46
ALA A 120
PHE A 274
LEU A 275
 None
 1.16A 6ew0G-4iq4A:
4.2		 6ew0G-4iq4A:
10.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iv6 ACYL-COA
DEHYDROGENASE FADE3

(Mycolicibacterium
smegmatis) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		5 VAL A 240
GLU A 239
LEU A 184
PHE A  98
LEU A 223
 None
 0.98A 6ew0G-4iv6A:
undetectable		 6ew0G-4iv6A:
11.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iv6 ACYL-COA
DEHYDROGENASE FADE3

(Mycolicibacterium
smegmatis) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		5 VAL A 348
ASP A 347
HIS A 337
ALA A 333
LEU A 284
 None
 1.17A 6ew0G-4iv6A:
undetectable		 6ew0G-4iv6A:
11.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jja HYPOTHETICAL PROTEIN

(Bacteroides
fragilis) 		PF07075
(DUF1343) 		5 ASP A 129
ALA A 198
LEU A 207
ARG A 143
LEU A 184
 None
None
None
None
GOL  A 403 ( 4.9A)
 1.14A 6ew0G-4jjaA:
3.0		 6ew0G-4jjaA:
13.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kfv GOLGI
REASSEMBLY-STACKING
PROTEIN 1

(Rattus
norvegicus) 		PF04495
(GRASP55_65) 		5 VAL A 117
ASP A 116
ALA A 123
SER A 121
LEU A 162
 None
 1.21A 6ew0G-4kfvA:
undetectable		 6ew0G-4kfvA:
15.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kt1 LEUCINE-RICH
REPEAT-CONTAINING
G-PROTEIN COUPLED
RECEPTOR 4

(Homo sapiens) 		PF01462
(LRRNT)
PF13516
(LRR_6)
PF13855
(LRR_8) 		5 LEU A  93
ALA A 124
LEU A 117
GLN A 113
LEU A 134
 None
 1.13A 6ew0G-4kt1A:
undetectable		 6ew0G-4kt1A:
10.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l68 LEUCINE-RICH REPEAT
PROTEIN KINASE-LIKE
PROTEIN

(Arabidopsis
thaliana) 		PF07714
(Pkinase_Tyr) 		5 VAL A 551
LEU A 387
ALA A 502
LEU A 391
LEU A 517
 None
 1.19A 6ew0G-4l68A:
undetectable		 6ew0G-4l68A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nru RNA DEPENDENT RNA
POLYMERASE

(Norwalk virus) 		PF00680
(RdRP_1) 		5 VAL A 324
ASP A 354
ALA A 320
LEU A 367
LEU A 379
 None
 1.09A 6ew0G-4nruA:
undetectable		 6ew0G-4nruA:
9.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p0s CROSSOVER JUNCTION
ENDONUCLEASE MUS81

(Homo sapiens) 		PF02732
(ERCC4) 		6 ASP A 404
GLU A 369
PHE A 308
LEU A 271
GLN A 292
LEU A 287
 None
 1.34A 6ew0G-4p0sA:
undetectable		 6ew0G-4p0sA:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p22 UBIQUITIN-LIKE
MODIFIER-ACTIVATING
ENZYME 1

(Homo sapiens) 		PF00899
(ThiF)
PF16190
(E1_FCCH)
PF16191
(E1_4HB) 		5 ASP A 111
LEU A 151
ALA A 128
SER A 131
LEU A  76
 None
 1.00A 6ew0G-4p22A:
undetectable		 6ew0G-4p22A:
10.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pu5 TOXIN-ANTITOXIN
SYSTEM TOXIN HIPA
FAMILY

(Shewanella
oneidensis) 		PF07804
(HipA_C)
PF13657
(Couple_hipA) 		5 VAL A 431
ASP A 430
GLU A 427
LEU A 293
LEU A 297
 None
 1.12A 6ew0G-4pu5A:
undetectable		 6ew0G-4pu5A:
11.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qmk TYPE III SECRETION
SYSTEM EFFECTOR
PROTEIN EXOU

(Pseudomonas
fluorescens) 		PF01734
(Patatin) 		5 VAL A  45
LEU A 458
ALA A 432
LEU A 441
LEU A  35
 None
 1.15A 6ew0G-4qmkA:
undetectable		 6ew0G-4qmkA:
9.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qxe LEUCINE-RICH
REPEAT-CONTAINING
G-PROTEIN COUPLED
RECEPTOR 4, LINKER,
VARIABLE LYMPHOCYTE
RECEPTOR B

(Eptatretus
burgeri;
Homo sapiens) 		PF01462
(LRRNT)
PF11921
(DUF3439)
PF13516
(LRR_6)
PF13855
(LRR_8) 		5 LEU A  93
ALA A 124
LEU A 117
GLN A 113
LEU A 134
 None
 1.03A 6ew0G-4qxeA:
undetectable		 6ew0G-4qxeA:
10.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qxf LEUCINE-RICH
REPEAT-CONTAINING
G-PROTEIN COUPLED
RECEPTOR 4, VARIABLE
LYMPHOCYTE RECEPTOR
B

(Eptatretus
burgeri;
Homo sapiens) 		PF01462
(LRRNT)
PF11921
(DUF3439)
PF13855
(LRR_8) 		5 LEU A  93
ALA A 124
LEU A 117
GLN A 113
LEU A 134
 None
 1.20A 6ew0G-4qxfA:
undetectable		 6ew0G-4qxfA:
14.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rq9 PHOTORECEPTOR-HISTID
INE KINASE BPHP

(Stigmatella
aurantiaca) 		PF01590
(GAF)
PF08446
(PAS_2) 		5 ASP A 105
LEU A  84
SER A 126
LEU A 121
LEU A  56
 None
None
GOL  A 415 ( 4.3A)
None
None
 1.19A 6ew0G-4rq9A:
undetectable		 6ew0G-4rq9A:
14.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4toi 30S RIBOSOMAL
PROTEIN S2,RIBOSOMAL
PROTEIN S1

(Escherichia
coli) 		PF00318
(Ribosomal_S2)
PF00575
(S1) 		5 VAL A 196
ASP A 197
LEU A 214
GLN A  89
LEU A  57
 None
 1.06A 6ew0G-4toiA:
undetectable		 6ew0G-4toiA:
14.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v2d FIBRONECTIN LEUCINE
RICH TRANSMEMBRANE
PROTEIN 2

(Homo sapiens) 		PF01463
(LRRCT)
PF13855
(LRR_8) 		5 LEU A  95
ALA A 128
PHE A 103
LEU A 116
LEU A 135
 None
 1.15A 6ew0G-4v2dA:
undetectable		 6ew0G-4v2dA:
13.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wfc EXOSOME COMPLEX
PROTEIN LRP1

(Saccharomyces
cerevisiae) 		PF04000
(Sas10_Utp3) 		5 LEU B  37
ALA B  54
SER B  58
LEU B  33
LEU B  28
 None
 1.18A 6ew0G-4wfcB:
undetectable		 6ew0G-4wfcB:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wrw URACIL-DNA
GLYCOSYLASE

(Mycobacterium
tuberculosis) 		PF03167
(UDG) 		5 VAL A  21
LEU A  63
PHE A  53
LEU A 124
LEU A 130
 None
 1.21A 6ew0G-4wrwA:
undetectable		 6ew0G-4wrwA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yzg PROTEIN PHOSPHATASE
2C 57

(Arabidopsis
thaliana) 		PF00481
(PP2C) 		5 VAL A  91
ASP A  75
ALA A 294
SER A 181
LEU A 328
 None
 1.14A 6ew0G-4yzgA:
undetectable		 6ew0G-4yzgA:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zvi DNA GYRASE SUBUNIT B

(Escherichia
coli) 		PF00204
(DNA_gyraseB)
PF02518
(HATPase_c) 		5 VAL A 123
LEU A 191
PHE A 182
LEU A 187
ARG A 190
 None
 1.17A 6ew0G-4zviA:
undetectable		 6ew0G-4zviA:
11.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d6c 4497 ANTIBODY IGG1
(VH AND CH1)

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		5 GLU B  85
SER B  62
PHE B  67
LEU B  80
LEU B  82
 None
 1.15A 6ew0G-5d6cB:
undetectable		 6ew0G-5d6cB:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dbx STE20/SPS1-RELATED
PROLINE-ALANINE-RICH
PROTEIN KINASE

(Mus musculus) 		PF00069
(Pkinase) 		5 LEU A 330
ALA A 279
PHE A 322
LEU A 326
LEU A 185
 None
 1.10A 6ew0G-5dbxA:
undetectable		 6ew0G-5dbxA:
14.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dih MICROCOMPARTMENTS
PROTEIN

(Haliangium
ochraceum) 		PF00936
(BMC) 		5 GLU A  26
LEU A 140
ALA A 132
LEU A 147
LEU A 105
 None
 1.19A 6ew0G-5dihA:
undetectable		 6ew0G-5dihA:
14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hzg STRIGOLACTONE
ESTERASE D14

(Arabidopsis
thaliana) 		PF12697
(Abhydrolase_6) 		5 ASP A  78
LEU A 119
ALA A 106
PHE A 114
LEU A 117
 None
 1.11A 6ew0G-5hzgA:
3.3		 6ew0G-5hzgA:
13.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iv8 LPS BIOSYNTHESIS
PROTEIN

(Klebsiella
pneumoniae) 		PF04453
(OstA_C) 		5 ASP A 629
GLU A 658
LEU A 536
ALA A 632
SER A 656
 None
 1.01A 6ew0G-5iv8A:
undetectable		 6ew0G-5iv8A:
9.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ivl DEAD-BOX
ATP-DEPENDENT RNA
HELICASE CSHA

(Geobacillus
stearothermophilus) 		no annotation 5 VAL B  42
ASP B  41
GLU B 201
LEU B   9
LEU B   7
 None
 1.03A 6ew0G-5ivlB:
undetectable		 6ew0G-5ivlB:
10.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lpy PROTEIN
BRASSINOSTEROID
INSENSITIVE 1

(Arabidopsis
thaliana) 		PF00069
(Pkinase) 		5 LEU A1127
ALA A 987
SER A 990
LEU A1080
LEU A 968
 None
 0.97A 6ew0G-5lpyA:
undetectable		 6ew0G-5lpyA:
12.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lpz PROTEIN
BRASSINOSTEROID
INSENSITIVE 1

(Arabidopsis
thaliana) 		PF00069
(Pkinase) 		5 LEU A1127
ALA A 987
SER A 990
LEU A1080
LEU A 968
 None
 1.06A 6ew0G-5lpzA:
undetectable		 6ew0G-5lpzA:
12.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lst ATP-DEPENDENT DNA
HELICASE Q4

(Homo sapiens) 		PF00270
(DEAD)
PF00271
(Helicase_C) 		5 VAL A 783
ASP A 782
LEU A 720
ALA A 785
LEU A 692
 None
 1.10A 6ew0G-5lstA:
undetectable		 6ew0G-5lstA:
7.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5mjs TUBULIN BETA CHAIN

(Schizosaccharomyces
pombe) 		no annotation 5 ASP A  26
LEU A 215
HIS A 227
ALA A 231
LEU A 360
 None
 1.08A 6ew0G-5mjsA:
59.4		 6ew0G-5mjsA:
75.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5mjs TUBULIN BETA CHAIN

(Schizosaccharomyces
pombe) 		no annotation 5 GLU A  27
LEU A 215
HIS A 227
ALA A 231
LEU A 360
 None
 1.12A 6ew0G-5mjsA:
59.4		 6ew0G-5mjsA:
75.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5n5n TUBULIN BETA CHAIN

(Homo sapiens) 		no annotation 10 VAL B  23
ASP B  26
GLU B  27
LEU B 217
HIS B 229
ALA B 233
PHE B 272
LEU B 275
GLN B 281
LEU B 371
 None
 0.80A 6ew0G-5n5nB:
62.1		 6ew0G-5n5nB:
93.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5n5n TUBULIN BETA CHAIN

(Homo sapiens) 		no annotation 10 VAL B  23
ASP B  26
GLU B  27
LEU B 217
HIS B 229
ALA B 233
SER B 236
PHE B 272
GLN B 281
LEU B 371
 None
 0.83A 6ew0G-5n5nB:
62.1		 6ew0G-5n5nB:
93.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5na2 CAPSID PROTEIN (P24)

(Feline
immunodeficiency
virus) 		no annotation 5 LEU A  46
PHE A  22
LEU A  54
ARG A 122
LEU A 129
 None
 1.21A 6ew0G-5na2A:
undetectable		 6ew0G-5na2A:
15.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nh1 GASDERMIN-D

(Homo sapiens) 		PF04598
(Gasdermin) 		5 GLU A 394
LEU A 469
ALA A 392
SER A 395
LEU A 441
 None
 1.13A 6ew0G-5nh1A:
undetectable		 6ew0G-5nh1A:
15.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ocl ANTI-LLAMA NANOBODY

(Vicugna pacos) 		PF07686
(V-set) 		5 GLU A  90
SER A  64
PHE A  69
LEU A  82
LEU A  87
 None
 1.17A 6ew0G-5oclA:
undetectable		 6ew0G-5oclA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uid AMINOTRANSFERASE
TLMJ

(Streptoalloteichus
hindustanus) 		PF01041
(DegT_DnrJ_EryC1) 		5 ALA A 159
SER A 296
ARG A 197
GLN A  51
LEU A  45
 None
 1.09A 6ew0G-5uidA:
undetectable		 6ew0G-5uidA:
12.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w3j TUBULIN BETA CHAIN

(Saccharomyces
cerevisiae) 		PF00091
(Tubulin)
PF03953
(Tubulin_C) 		5 VAL B  23
ASP B  26
GLU B  27
GLN B 279
LEU B 361
 TA1  B 502 (-3.9A)
TA1  B 502 (-4.1A)
TA1  B 502 (-3.6A)
TA1  B 502 ( 4.3A)
TA1  B 502 (-3.7A)
 1.10A 6ew0G-5w3jB:
60.4		 6ew0G-5w3jB:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w3j TUBULIN BETA CHAIN

(Saccharomyces
cerevisiae) 		PF00091
(Tubulin)
PF03953
(Tubulin_C) 		6 VAL B  23
ASP B  26
GLU B  27
LEU B 215
SER B 234
LEU B 361
 TA1  B 502 (-3.9A)
TA1  B 502 (-4.1A)
TA1  B 502 (-3.6A)
None
TA1  B 502 ( 4.9A)
TA1  B 502 (-3.7A)
 0.80A 6ew0G-5w3jB:
60.4		 6ew0G-5w3jB:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w4b ADENOSYLHOMOCYSTEINA
SE

(Homo sapiens) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		5 GLU A 105
LEU A 344
SER A  78
LEU A 347
GLN A 324
 None
NAD  A 501 (-4.0A)
None
9W4  A 502 (-4.1A)
9W4  A 502 (-4.2A)
 1.15A 6ew0G-5w4bA:
6.1		 6ew0G-5w4bA:
10.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5way TRANSCRIPTIONAL
ACTIVATOR

(Streptococcus
pneumoniae) 		PF05043
(Mga)
PF08270
(PRD_Mga)
PF08280
(HTH_Mga) 		5 HIS A  48
ALA A  52
PHE A  53
LEU A  16
ARG A  11
 None
 1.12A 6ew0G-5wayA:
undetectable		 6ew0G-5wayA:
10.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5way TRANSCRIPTIONAL
ACTIVATOR

(Streptococcus
pneumoniae) 		PF05043
(Mga)
PF08270
(PRD_Mga)
PF08280
(HTH_Mga) 		5 LEU A  15
ALA A  52
PHE A  53
LEU A  16
ARG A  11
 None
 1.09A 6ew0G-5wayA:
undetectable		 6ew0G-5wayA:
10.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y59 ATP-DEPENDENT DNA
HELICASE II SUBUNIT
2

(Saccharomyces
cerevisiae) 		no annotation 5 VAL B 113
ASP B 116
LEU B  87
LEU B  29
ARG B  86
 None
 1.11A 6ew0G-5y59B:
3.2		 6ew0G-5y59B:
16.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y6q ALDEHYDE OXIDASE
MEDIUM SUBUNIT

(Methylobacillus
sp. KY4400) 		no annotation 5 LEU B  59
ALA B  87
SER B 228
LEU B  77
LEU B 170
 None
 0.84A 6ew0G-5y6qB:
undetectable		 6ew0G-5y6qB:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yl7 PSEUDOALTEROMONAS
ARCTICA PAMC 21717

(Pseudoalteromonas
arctica) 		no annotation 5 VAL A 181
ASP A 310
LEU A 167
LEU A 165
LEU A 454
 None
 1.00A 6ew0G-5yl7A:
undetectable		 6ew0G-5yl7A:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ap6 PROBABLE
STRIGOLACTONE
ESTERASE DAD2

(Petunia x
hybrida) 		no annotation 5 ASP A  77
LEU A 118
ALA A 105
PHE A 113
LEU A 116
 None
 1.08A 6ew0G-6ap6A:
undetectable		 6ew0G-6ap6A:
18.18