SIMILAR PATTERNS OF AMINO ACIDS FOR 6EW0_G_TA1G501

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1brt BROMOPEROXIDASE A2

(Kitasatospora
aureofaciens) 		PF00561
(Abhydrolase_1) 		5 VAL A 104
LEU A  46
ALA A 120
PHE A 274
LEU A 275
 None
 1.19A 6ew0G-1brtA:
4.1		 6ew0G-1brtA:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h2b ALCOHOL
DEHYDROGENASE

(Aeropyrum
pernix) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 VAL A  33
ASP A  32
GLU A  31
ARG A  47
LEU A 336
 None
 1.19A 6ew0G-1h2bA:
3.2		 6ew0G-1h2bA:
12.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h8l CARBOXYPEPTIDASE
GP180 RESIDUES
503-882

(Lophonetta
specularioides) 		PF00246
(Peptidase_M14)
PF13620
(CarboxypepD_reg) 		5 VAL A 368
ASP A 369
LEU A 176
LEU A 213
GLN A 297
 None
 1.12A 6ew0G-1h8lA:
undetectable		 6ew0G-1h8lA:
11.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hkk CHITOTRIOSIDASE-1

(Homo sapiens) 		PF00704
(Glyco_hydro_18) 		5 VAL A 243
ASP A 244
LEU A 385
SER A 226
LEU A 381
 None
 1.18A 6ew0G-1hkkA:
undetectable		 6ew0G-1hkkA:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jxn ANTI-H(O) LECTIN I

(Ulex europaeus) 		PF00139
(Lectin_legB) 		5 VAL A 124
ASP A 146
PHE A  68
ARG A  50
LEU A 206
 None
 1.20A 6ew0G-1jxnA:
undetectable		 6ew0G-1jxnA:
15.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qgu PROTEIN (NITROGENASE
MOLYBDENUM IRON
PROTEIN)

(Klebsiella
pneumoniae) 		PF00148
(Oxidored_nitro) 		5 GLU A 425
LEU A  11
ALA A 402
PHE A 399
LEU A 397
 None
 1.18A 6ew0G-1qguA:
undetectable		 6ew0G-1qguA:
11.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t6p PHENYLALANINE
AMMONIA-LYASE

(Rhodotorula
toruloides) 		PF00221
(Lyase_aromatic) 		5 LEU A 532
ALA A 701
SER A 704
LEU A 528
LEU A 711
 None
 1.13A 6ew0G-1t6pA:
undetectable		 6ew0G-1t6pA:
7.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u0u DIHYDROPINOSYLVIN
SYNTHASE

(Pinus
sylvestris) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		5 VAL A 105
LEU A 153
ALA A 109
LEU A 190
ARG A 159
 None
 1.21A 6ew0G-1u0uA:
undetectable		 6ew0G-1u0uA:
12.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vf8 SECRETORY PROTEIN

(Mus musculus) 		PF00704
(Glyco_hydro_18) 		5 VAL A 222
ASP A 223
LEU A 366
SER A 205
LEU A 362
 None
 1.18A 6ew0G-1vf8A:
undetectable		 6ew0G-1vf8A:
12.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w8o BACTERIAL SIALIDASE

(Micromonospora
viridifaciens) 		PF00754
(F5_F8_type_C)
PF10633
(NPCBM_assoc)
PF13088
(BNR_2) 		5 GLU A 644
ALA A 612
PHE A 603
ARG A 623
LEU A 641
 None
 1.18A 6ew0G-1w8oA:
undetectable		 6ew0G-1w8oA:
9.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wb0 CHITOTRIOSIDASE 1

(Homo sapiens) 		PF00704
(Glyco_hydro_18) 		5 VAL A 243
ASP A 244
LEU A 387
SER A 226
LEU A 383
 None
 1.16A 6ew0G-1wb0A:
undetectable		 6ew0G-1wb0A:
11.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xa6 BETA2-CHIMAERIN

(Homo sapiens) 		PF00017
(SH2)
PF00130
(C1_1)
PF00620
(RhoGAP) 		5 VAL A 411
LEU A 401
PHE A 429
LEU A 433
LEU A 350
 None
 1.19A 6ew0G-1xa6A:
undetectable		 6ew0G-1xa6A:
11.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y4u CHAPERONE PROTEIN
HTPG

(Escherichia
coli) 		PF00183
(HSP90)
PF02518
(HATPase_c) 		5 GLU A 273
LEU A 278
SER A 328
LEU A 352
GLN A 358
 None
 1.21A 6ew0G-1y4uA:
undetectable		 6ew0G-1y4uA:
10.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zv5 IMMUNOGLOBULIN HEAVY
CHAIN ANTIBODY
VARIABLE DOMAIN

(Camelus
dromedarius) 		PF07686
(V-set) 		5 GLU A  89
SER A  63
PHE A  68
LEU A  81
LEU A  86
 None
 1.17A 6ew0G-1zv5A:
undetectable		 6ew0G-1zv5A:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a7m N-ACYL HOMOSERINE
LACTONE HYDROLASE

(Bacillus
thuringiensis) 		PF00753
(Lactamase_B) 		5 GLU A 127
LEU A 187
SER A 170
LEU A 220
GLN A 162
 None
 1.15A 6ew0G-2a7mA:
undetectable		 6ew0G-2a7mA:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cuk GLYCERATE
DEHYDROGENASE/GLYOXY
LATE REDUCTASE

(Thermus
thermophilus) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		5 ASP A  53
LEU A  22
ALA A  70
LEU A 301
LEU A  66
 None
 1.13A 6ew0G-2cukA:
undetectable		 6ew0G-2cukA:
15.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e5a LIPOYLTRANSFERASE 1

(Bos taurus) 		no annotation 5 VAL A 114
LEU A  39
ALA A 110
LEU A  89
ARG A  41
 None
 1.10A 6ew0G-2e5aA:
undetectable		 6ew0G-2e5aA:
15.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g2o MALONYL COA-ACYL
CARRIER PROTEIN
TRANSACYLASE

(Escherichia
coli) 		PF00698
(Acyl_transf_1) 		5 VAL A 100
LEU A  44
ALA A 110
GLN A  14
LEU A  93
 None
None
None
None
SO4  A1001 (-4.3A)
 1.12A 6ew0G-2g2oA:
undetectable		 6ew0G-2g2oA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g3k VACUOLAR PROTEIN
SORTING-ASSOCIATED
PROTEIN VPS28

(Saccharomyces
cerevisiae) 		PF03997
(VPS28) 		5 LEU A 181
ALA A 233
SER A 236
PHE A 160
LEU A 184
 None
 1.21A 6ew0G-2g3kA:
undetectable		 6ew0G-2g3kA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ip4 PHOSPHORIBOSYLAMINE-
-GLYCINE LIGASE

(Thermus
thermophilus) 		PF01071
(GARS_A)
PF02843
(GARS_C)
PF02844
(GARS_N) 		5 VAL A 305
PHE A 282
LEU A  15
GLN A  21
LEU A 294
 None
 1.19A 6ew0G-2ip4A:
undetectable		 6ew0G-2ip4A:
12.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iy8 PROTEIN PM0188

(Pasteurella
multocida) 		PF11477
(PM0188) 		5 LEU A 138
ALA A 192
PHE A 193
LEU A 136
LEU A 121
 None
 0.99A 6ew0G-2iy8A:
5.2		 6ew0G-2iy8A:
11.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nbr GAMMA-CRYSTALLIN C

(Homo sapiens) 		PF00030
(Crystall) 		5 ASP A 113
ALA A 163
LEU A 145
ARG A 167
LEU A 104
 None
 1.18A 6ew0G-2nbrA:
undetectable		 6ew0G-2nbrA:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2osa N-CHIMAERIN

(Homo sapiens) 		PF00620
(RhoGAP) 		5 VAL A 404
LEU A 394
PHE A 422
LEU A 426
LEU A 343
 None
 1.21A 6ew0G-2osaA:
undetectable		 6ew0G-2osaA:
16.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qx2 SEX PHEROMONE
STAPH-CAM373

(Staphylococcus
aureus) 		PF07537
(CamS) 		5 GLU A 227
LEU A  86
ALA A 225
PHE A 245
LEU A 232
 None
None
None
None
EDO  A 401 ( 4.9A)
 1.14A 6ew0G-2qx2A:
undetectable		 6ew0G-2qx2A:
11.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ybu ACIDIC MAMMALIAN
CHITINASE

(Homo sapiens) 		PF00704
(Glyco_hydro_18) 		5 VAL A 243
ASP A 244
LEU A 387
SER A 226
LEU A 383
 None
 1.16A 6ew0G-2ybuA:
undetectable		 6ew0G-2ybuA:
11.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zgd 3 REPEAT SYNTHETIC
ANKYRIN

(-) 		PF12796
(Ank_2) 		5 VAL A  40
ASP A  38
GLU A  39
LEU A 105
ALA A  32
 None
CD  A 413 ( 2.4A)
CD  A 410 ( 2.1A)
None
None
 1.08A 6ew0G-2zgdA:
undetectable		 6ew0G-2zgdA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3blx ISOCITRATE
DEHYDROGENASE [NAD]
SUBUNIT 2

(Saccharomyces
cerevisiae) 		PF00180
(Iso_dh) 		5 GLU B  54
LEU B  99
ALA B  73
SER B  76
LEU B 103
 None
 1.13A 6ew0G-3blxB:
undetectable		 6ew0G-3blxB:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cfx UPF0100 PROTEIN
MA_0280

(Methanosarcina
acetivorans) 		PF13531
(SBP_bac_11) 		5 LEU A  58
ALA A 119
PHE A 118
LEU A 315
ARG A  73
 None
 1.18A 6ew0G-3cfxA:
undetectable		 6ew0G-3cfxA:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cxl N-CHIMERIN

(Homo sapiens) 		PF00017
(SH2)
PF00130
(C1_1)
PF00620
(RhoGAP) 		5 VAL A 404
LEU A 394
PHE A 422
LEU A 426
LEU A 343
 None
 1.12A 6ew0G-3cxlA:
undetectable		 6ew0G-3cxlA:
11.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3foa TAIL SHEATH PROTEIN
GP18

(Escherichia
virus T4) 		PF04984
(Phage_sheath_1)
PF17481
(Phage_sheath_1N) 		5 VAL A 370
ASP A 369
ALA A  27
PHE A  71
LEU A  72
 None
 1.11A 6ew0G-3foaA:
undetectable		 6ew0G-3foaA:
8.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h2b SAM-DEPENDENT
METHYLTRANSFERASE

(Corynebacterium
glutamicum) 		PF13649
(Methyltransf_25) 		5 VAL A 105
ASP A 104
LEU A 222
PHE A 231
LEU A 226
 None
SAH  A 301 ( 4.4A)
None
None
None
 1.15A 6ew0G-3h2bA:
undetectable		 6ew0G-3h2bA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h9c METHIONYL-TRNA
SYNTHETASE

(Escherichia
coli) 		PF09334
(tRNA-synt_1g) 		5 LEU A 510
ALA A 393
PHE A 505
LEU A 506
LEU A 408
 None
 1.20A 6ew0G-3h9cA:
undetectable		 6ew0G-3h9cA:
10.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hjh TRANSCRIPTION-REPAIR
-COUPLING FACTOR

(Escherichia
coli) 		no annotation 5 GLU A 431
LEU A 441
ALA A  25
PHE A  62
LEU A 415
 None
 1.10A 6ew0G-3hjhA:
undetectable		 6ew0G-3hjhA:
9.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hjv MALONYL COA-ACYL
CARRIER PROTEIN
TRANSACYLASE

(Vibrio cholerae) 		PF00698
(Acyl_transf_1) 		5 VAL A 105
LEU A  49
ALA A 115
GLN A  19
LEU A  98
 None
None
None
CL  A 328 (-3.5A)
None
 1.13A 6ew0G-3hjvA:
undetectable		 6ew0G-3hjvA:
13.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hl1 FERRITIN LIKE
PROTEIN

(Caulobacter
vibrioides) 		PF12902
(Ferritin-like) 		5 VAL A 183
LEU A  10
ALA A 194
LEU A 150
GLN A  15
 None
 1.18A 6ew0G-3hl1A:
undetectable		 6ew0G-3hl1A:
14.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hva PROTEIN FIMX

(Pseudomonas
aeruginosa) 		PF00990
(GGDEF) 		5 VAL A 373
LEU A 275
PHE A 336
LEU A 342
ARG A 344
 None
 1.15A 6ew0G-3hvaA:
undetectable		 6ew0G-3hvaA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3im8 MALONYL ACYL CARRIER
PROTEIN TRANSACYLASE

(Streptococcus
pneumoniae) 		PF00698
(Acyl_transf_1) 		5 VAL A  98
LEU A  44
ALA A 108
GLN A  14
LEU A  91
 None
 1.08A 6ew0G-3im8A:
undetectable		 6ew0G-3im8A:
14.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iu1 GLYCYLPEPTIDE
N-TETRADECANOYLTRANS
FERASE 1

(Homo sapiens) 		PF01233
(NMT)
PF02799
(NMT_C) 		5 LEU A 329
ALA A 419
PHE A 450
LEU A 439
LEU A 398
 None
 1.11A 6ew0G-3iu1A:
undetectable		 6ew0G-3iu1A:
12.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j2n TAIL SHEATH PROTEIN
GP18

(Escherichia
virus T4) 		PF04984
(Phage_sheath_1)
PF17481
(Phage_sheath_1N)
PF17482
(Phage_sheath_1C) 		5 VAL U 370
ASP U 369
ALA U  27
PHE U  71
LEU U  72
 None
 1.11A 6ew0G-3j2nU:
3.7		 6ew0G-3j2nU:
9.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k8p DSL1

(Kluyveromyces
lactis) 		PF11989
(Dsl1_C) 		5 ALA C 434
PHE C 468
LEU C 499
ARG C 487
LEU C 482
 None
 1.18A 6ew0G-3k8pC:
undetectable		 6ew0G-3k8pC:
12.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lmd GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE

(Corynebacterium
glutamicum) 		PF00348
(polyprenyl_synt) 		5 VAL A 277
GLU A 273
LEU A 289
SER A 305
LEU A 258
 None
 1.07A 6ew0G-3lmdA:
undetectable		 6ew0G-3lmdA:
10.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oak TRANSCRIPTION FACTOR
IWS1

(Saccharomyces
cerevisiae) 		PF08711
(Med26) 		6 ASP A 163
GLU A 164
LEU A 225
LEU A 242
ARG A 222
LEU A 217
 None
 1.30A 6ew0G-3oakA:
undetectable		 6ew0G-3oakA:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3shu TIGHT JUNCTION
PROTEIN ZO-1

(Homo sapiens) 		PF00595
(PDZ) 		5 VAL A  35
ALA A  41
SER A  39
PHE A  12
LEU A  72
 None
 0.93A 6ew0G-3shuA:
undetectable		 6ew0G-3shuA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3shw TIGHT JUNCTION
PROTEIN ZO-1

(Homo sapiens) 		PF00595
(PDZ)
PF00625
(Guanylate_kin)
PF07653
(SH3_2) 		5 VAL A 450
ALA A 456
SER A 454
PHE A 427
LEU A 487
 None
 0.98A 6ew0G-3shwA:
undetectable		 6ew0G-3shwA:
11.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tsv TIGHT JUNCTION
PROTEIN ZO-1

(Homo sapiens) 		PF00595
(PDZ) 		5 VAL A 450
ALA A 456
SER A 454
PHE A 427
LEU A 487
 None
 1.03A 6ew0G-3tsvA:
undetectable		 6ew0G-3tsvA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w04 DWARF 88 ESTERASE

(Oryza sativa) 		PF12697
(Abhydrolase_6) 		5 ASP A 128
LEU A 169
ALA A 156
PHE A 164
LEU A 167
 None
 1.14A 6ew0G-3w04A:
3.7		 6ew0G-3w04A:
15.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zi1 GLYOXALASE
DOMAIN-CONTAINING
PROTEIN 4

(Homo sapiens) 		no annotation 5 ALA A 119
PHE A 125
LEU A  27
ARG A  24
LEU A  71
 None
 1.21A 6ew0G-3zi1A:
undetectable		 6ew0G-3zi1A:
14.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a11 DNA EXCISION REPAIR
PROTEIN ERCC-8

(Homo sapiens) 		PF00400
(WD40) 		5 LEU B 226
ALA B 191
SER B 146
LEU B 260
ARG B 270
 None
 1.21A 6ew0G-4a11B:
undetectable		 6ew0G-4a11B:
10.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c2x GLYCYLPEPTIDE
N-TETRADECANOYLTRANS
FERASE 2

(Homo sapiens) 		PF01233
(NMT)
PF02799
(NMT_C) 		5 LEU A 329
ALA A 419
PHE A 450
LEU A 439
LEU A 398
 None
 1.12A 6ew0G-4c2xA:
undetectable		 6ew0G-4c2xA:
11.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cp6 CHOLINE BINDING
PROTEIN PCPA

(Streptococcus
pneumoniae) 		PF13306
(LRR_5) 		5 LEU A 217
ALA A 182
PHE A 183
LEU A 192
LEU A 175
 None
 1.07A 6ew0G-4cp6A:
undetectable		 6ew0G-4cp6A:
11.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fmc RORF2

(Escherichia
coli) 		PF06872
(EspG) 		5 VAL A 340
LEU A 234
ALA A 290
SER A 342
PHE A 291
 None
 1.16A 6ew0G-4fmcA:
undetectable		 6ew0G-4fmcA:
12.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gfa SPINDLE ASSEMBLY
ABNORMAL PROTEIN 6

(Caenorhabditis
elegans) 		PF16531
(SAS-6_N) 		5 VAL A  85
ASP A  86
LEU A  98
PHE A 126
LEU A  69
 None
 1.18A 6ew0G-4gfaA:
undetectable		 6ew0G-4gfaA:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hes BETA-LACTAMASE CLASS
A-LIKE PROTEIN

(Veillonella
parvula) 		PF13354
(Beta-lactamase2) 		5 VAL A 224
ASP A 222
ALA A  55
SER A  53
GLN A  96
 None
 1.20A 6ew0G-4hesA:
undetectable		 6ew0G-4hesA:
13.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iq4 NON-HAEM
BROMOPEROXIDASE
BPO-A2, MATRIX
PROTEIN 1

(Influenza A
virus;
Kitasatospora
aureofaciens) 		PF00561
(Abhydrolase_1)
PF00598
(Flu_M1) 		5 VAL A 104
LEU A  46
ALA A 120
PHE A 274
LEU A 275
 None
 1.16A 6ew0G-4iq4A:
4.2		 6ew0G-4iq4A:
10.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iv6 ACYL-COA
DEHYDROGENASE FADE3

(Mycolicibacterium
smegmatis) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		5 VAL A 240
GLU A 239
LEU A 184
PHE A  98
LEU A 223
 None
 0.98A 6ew0G-4iv6A:
undetectable		 6ew0G-4iv6A:
11.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iv6 ACYL-COA
DEHYDROGENASE FADE3

(Mycolicibacterium
smegmatis) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		5 VAL A 348
ASP A 347
HIS A 337
ALA A 333
LEU A 284
 None
 1.17A 6ew0G-4iv6A:
undetectable		 6ew0G-4iv6A:
11.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jja HYPOTHETICAL PROTEIN

(Bacteroides
fragilis) 		PF07075
(DUF1343) 		5 ASP A 129
ALA A 198
LEU A 207
ARG A 143
LEU A 184
 None
None
None
None
GOL  A 403 ( 4.9A)
 1.14A 6ew0G-4jjaA:
3.0		 6ew0G-4jjaA:
13.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kfv GOLGI
REASSEMBLY-STACKING
PROTEIN 1

(Rattus
norvegicus) 		PF04495
(GRASP55_65) 		5 VAL A 117
ASP A 116
ALA A 123
SER A 121
LEU A 162
 None
 1.21A 6ew0G-4kfvA:
undetectable		 6ew0G-4kfvA:
15.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kt1 LEUCINE-RICH
REPEAT-CONTAINING
G-PROTEIN COUPLED
RECEPTOR 4

(Homo sapiens) 		PF01462
(LRRNT)
PF13516
(LRR_6)
PF13855
(LRR_8) 		5 LEU A  93
ALA A 124
LEU A 117
GLN A 113
LEU A 134
 None
 1.13A 6ew0G-4kt1A:
undetectable		 6ew0G-4kt1A:
10.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l68 LEUCINE-RICH REPEAT
PROTEIN KINASE-LIKE
PROTEIN

(Arabidopsis
thaliana) 		PF07714
(Pkinase_Tyr) 		5 VAL A 551
LEU A 387
ALA A 502
LEU A 391
LEU A 517
 None
 1.19A 6ew0G-4l68A:
undetectable		 6ew0G-4l68A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nru RNA DEPENDENT RNA
POLYMERASE

(Norwalk virus) 		PF00680
(RdRP_1) 		5 VAL A 324
ASP A 354
ALA A 320
LEU A 367
LEU A 379
 None
 1.09A 6ew0G-4nruA:
undetectable		 6ew0G-4nruA:
9.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p0s CROSSOVER JUNCTION
ENDONUCLEASE MUS81

(Homo sapiens) 		PF02732
(ERCC4) 		6 ASP A 404
GLU A 369
PHE A 308
LEU A 271
GLN A 292
LEU A 287
 None
 1.34A 6ew0G-4p0sA:
undetectable		 6ew0G-4p0sA:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p22 UBIQUITIN-LIKE
MODIFIER-ACTIVATING
ENZYME 1

(Homo sapiens) 		PF00899
(ThiF)
PF16190
(E1_FCCH)
PF16191
(E1_4HB) 		5 ASP A 111
LEU A 151
ALA A 128
SER A 131
LEU A  76
 None
 1.00A 6ew0G-4p22A:
undetectable		 6ew0G-4p22A:
10.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pu5 TOXIN-ANTITOXIN
SYSTEM TOXIN HIPA
FAMILY

(Shewanella
oneidensis) 		PF07804
(HipA_C)
PF13657
(Couple_hipA) 		5 VAL A 431
ASP A 430
GLU A 427
LEU A 293
LEU A 297
 None
 1.12A 6ew0G-4pu5A:
undetectable		 6ew0G-4pu5A:
11.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qmk TYPE III SECRETION
SYSTEM EFFECTOR
PROTEIN EXOU

(Pseudomonas
fluorescens) 		PF01734
(Patatin) 		5 VAL A  45
LEU A 458
ALA A 432
LEU A 441
LEU A  35
 None
 1.15A 6ew0G-4qmkA:
undetectable		 6ew0G-4qmkA:
9.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qxe LEUCINE-RICH
REPEAT-CONTAINING
G-PROTEIN COUPLED
RECEPTOR 4, LINKER,
VARIABLE LYMPHOCYTE
RECEPTOR B

(Eptatretus
burgeri;
Homo sapiens) 		PF01462
(LRRNT)
PF11921
(DUF3439)
PF13516
(LRR_6)
PF13855
(LRR_8) 		5 LEU A  93
ALA A 124
LEU A 117
GLN A 113
LEU A 134
 None
 1.03A 6ew0G-4qxeA:
undetectable		 6ew0G-4qxeA:
10.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qxf LEUCINE-RICH
REPEAT-CONTAINING
G-PROTEIN COUPLED
RECEPTOR 4, VARIABLE
LYMPHOCYTE RECEPTOR
B

(Eptatretus
burgeri;
Homo sapiens) 		PF01462
(LRRNT)
PF11921
(DUF3439)
PF13855
(LRR_8) 		5 LEU A  93
ALA A 124
LEU A 117
GLN A 113
LEU A 134
 None
 1.20A 6ew0G-4qxfA:
undetectable		 6ew0G-4qxfA:
14.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rq9 PHOTORECEPTOR-HISTID
INE KINASE BPHP

(Stigmatella
aurantiaca) 		PF01590
(GAF)
PF08446
(PAS_2) 		5 ASP A 105
LEU A  84
SER A 126
LEU A 121
LEU A  56
 None
None
GOL  A 415 ( 4.3A)
None
None
 1.19A 6ew0G-4rq9A:
undetectable		 6ew0G-4rq9A:
14.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4toi 30S RIBOSOMAL
PROTEIN S2,RIBOSOMAL
PROTEIN S1

(Escherichia
coli) 		PF00318
(Ribosomal_S2)
PF00575
(S1) 		5 VAL A 196
ASP A 197
LEU A 214
GLN A  89
LEU A  57
 None
 1.06A 6ew0G-4toiA:
undetectable		 6ew0G-4toiA:
14.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v2d FIBRONECTIN LEUCINE
RICH TRANSMEMBRANE
PROTEIN 2

(Homo sapiens) 		PF01463
(LRRCT)
PF13855
(LRR_8) 		5 LEU A  95
ALA A 128
PHE A 103
LEU A 116
LEU A 135
 None
 1.15A 6ew0G-4v2dA:
undetectable		 6ew0G-4v2dA:
13.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wfc EXOSOME COMPLEX
PROTEIN LRP1

(Saccharomyces
cerevisiae) 		PF04000
(Sas10_Utp3) 		5 LEU B  37
ALA B  54
SER B  58
LEU B  33
LEU B  28
 None
 1.18A 6ew0G-4wfcB:
undetectable		 6ew0G-4wfcB:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wrw URACIL-DNA
GLYCOSYLASE

(Mycobacterium
tuberculosis) 		PF03167
(UDG) 		5 VAL A  21
LEU A  63
PHE A  53
LEU A 124
LEU A 130
 None
 1.21A 6ew0G-4wrwA:
undetectable		 6ew0G-4wrwA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yzg PROTEIN PHOSPHATASE
2C 57

(Arabidopsis
thaliana) 		PF00481
(PP2C) 		5 VAL A  91
ASP A  75
ALA A 294
SER A 181
LEU A 328
 None
 1.14A 6ew0G-4yzgA:
undetectable		 6ew0G-4yzgA:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zvi DNA GYRASE SUBUNIT B

(Escherichia
coli) 		PF00204
(DNA_gyraseB)
PF02518
(HATPase_c) 		5 VAL A 123
LEU A 191
PHE A 182
LEU A 187
ARG A 190
 None
 1.17A 6ew0G-4zviA:
undetectable		 6ew0G-4zviA:
11.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d6c 4497 ANTIBODY IGG1
(VH AND CH1)

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		5 GLU B  85
SER B  62
PHE B  67
LEU B  80
LEU B  82
 None
 1.15A 6ew0G-5d6cB:
undetectable		 6ew0G-5d6cB:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dbx STE20/SPS1-RELATED
PROLINE-ALANINE-RICH
PROTEIN KINASE

(Mus musculus) 		PF00069
(Pkinase) 		5 LEU A 330
ALA A 279
PHE A 322
LEU A 326
LEU A 185
 None
 1.10A 6ew0G-5dbxA:
undetectable		 6ew0G-5dbxA:
14.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dih MICROCOMPARTMENTS
PROTEIN

(Haliangium
ochraceum) 		PF00936
(BMC) 		5 GLU A  26
LEU A 140
ALA A 132
LEU A 147
LEU A 105
 None
 1.19A 6ew0G-5dihA:
undetectable		 6ew0G-5dihA:
14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hzg STRIGOLACTONE
ESTERASE D14

(Arabidopsis
thaliana) 		PF12697
(Abhydrolase_6) 		5 ASP A  78
LEU A 119
ALA A 106
PHE A 114
LEU A 117
 None
 1.11A 6ew0G-5hzgA:
3.3		 6ew0G-5hzgA:
13.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iv8 LPS BIOSYNTHESIS
PROTEIN

(Klebsiella
pneumoniae) 		PF04453
(OstA_C) 		5 ASP A 629
GLU A 658
LEU A 536
ALA A 632
SER A 656
 None
 1.01A 6ew0G-5iv8A:
undetectable		 6ew0G-5iv8A:
9.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ivl DEAD-BOX
ATP-DEPENDENT RNA
HELICASE CSHA

(Geobacillus
stearothermophilus) 		no annotation 5 VAL B  42
ASP B  41
GLU B 201
LEU B   9
LEU B   7
 None
 1.03A 6ew0G-5ivlB:
undetectable		 6ew0G-5ivlB:
10.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lpy PROTEIN
BRASSINOSTEROID
INSENSITIVE 1

(Arabidopsis
thaliana) 		PF00069
(Pkinase) 		5 LEU A1127
ALA A 987
SER A 990
LEU A1080
LEU A 968
 None
 0.97A 6ew0G-5lpyA:
undetectable		 6ew0G-5lpyA:
12.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lpz PROTEIN
BRASSINOSTEROID
INSENSITIVE 1

(Arabidopsis
thaliana) 		PF00069
(Pkinase) 		5 LEU A1127
ALA A 987
SER A 990
LEU A1080
LEU A 968
 None
 1.06A 6ew0G-5lpzA:
undetectable		 6ew0G-5lpzA:
12.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lst ATP-DEPENDENT DNA
HELICASE Q4

(Homo sapiens) 		PF00270
(DEAD)
PF00271
(Helicase_C) 		5 VAL A 783
ASP A 782
LEU A 720
ALA A 785
LEU A 692
 None
 1.10A 6ew0G-5lstA:
undetectable		 6ew0G-5lstA:
7.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5mjs TUBULIN BETA CHAIN

(Schizosaccharomyces
pombe) 		no annotation 5 ASP A  26
LEU A 215
HIS A 227
ALA A 231
LEU A 360
 None
 1.08A 6ew0G-5mjsA:
59.4		 6ew0G-5mjsA:
75.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5mjs TUBULIN BETA CHAIN

(Schizosaccharomyces
pombe) 		no annotation 5 GLU A  27
LEU A 215
HIS A 227
ALA A 231
LEU A 360
 None
 1.12A 6ew0G-5mjsA:
59.4		 6ew0G-5mjsA:
75.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5n5n TUBULIN BETA CHAIN

(Homo sapiens) 		no annotation 10 VAL B  23
ASP B  26
GLU B  27
LEU B 217
HIS B 229
ALA B 233
PHE B 272
LEU B 275
GLN B 281
LEU B 371
 None
 0.80A 6ew0G-5n5nB:
62.1		 6ew0G-5n5nB:
93.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5n5n TUBULIN BETA CHAIN

(Homo sapiens) 		no annotation 10 VAL B  23
ASP B  26
GLU B  27
LEU B 217
HIS B 229
ALA B 233
SER B 236
PHE B 272
GLN B 281
LEU B 371
 None
 0.83A 6ew0G-5n5nB:
62.1		 6ew0G-5n5nB:
93.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5na2 CAPSID PROTEIN (P24)

(Feline
immunodeficiency
virus) 		no annotation 5 LEU A  46
PHE A  22
LEU A  54
ARG A 122
LEU A 129
 None
 1.21A 6ew0G-5na2A:
undetectable		 6ew0G-5na2A:
15.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nh1 GASDERMIN-D

(Homo sapiens) 		PF04598
(Gasdermin) 		5 GLU A 394
LEU A 469
ALA A 392
SER A 395
LEU A 441
 None
 1.13A 6ew0G-5nh1A:
undetectable		 6ew0G-5nh1A:
15.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ocl ANTI-LLAMA NANOBODY

(Vicugna pacos) 		PF07686
(V-set) 		5 GLU A  90
SER A  64
PHE A  69
LEU A  82
LEU A  87
 None
 1.17A 6ew0G-5oclA:
undetectable		 6ew0G-5oclA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uid AMINOTRANSFERASE
TLMJ

(Streptoalloteichus
hindustanus) 		PF01041
(DegT_DnrJ_EryC1) 		5 ALA A 159
SER A 296
ARG A 197
GLN A  51
LEU A  45
 None
 1.09A 6ew0G-5uidA:
undetectable		 6ew0G-5uidA:
12.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w3j TUBULIN BETA CHAIN

(Saccharomyces
cerevisiae) 		PF00091
(Tubulin)
PF03953
(Tubulin_C) 		5 VAL B  23
ASP B  26
GLU B  27
GLN B 279
LEU B 361
 TA1  B 502 (-3.9A)
TA1  B 502 (-4.1A)
TA1  B 502 (-3.6A)
TA1  B 502 ( 4.3A)
TA1  B 502 (-3.7A)
 1.10A 6ew0G-5w3jB:
60.4		 6ew0G-5w3jB:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w3j TUBULIN BETA CHAIN

(Saccharomyces
cerevisiae) 		PF00091
(Tubulin)
PF03953
(Tubulin_C) 		6 VAL B  23
ASP B  26
GLU B  27
LEU B 215
SER B 234
LEU B 361
 TA1  B 502 (-3.9A)
TA1  B 502 (-4.1A)
TA1  B 502 (-3.6A)
None
TA1  B 502 ( 4.9A)
TA1  B 502 (-3.7A)
 0.80A 6ew0G-5w3jB:
60.4		 6ew0G-5w3jB:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w4b ADENOSYLHOMOCYSTEINA
SE

(Homo sapiens) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		5 GLU A 105
LEU A 344
SER A  78
LEU A 347
GLN A 324
 None
NAD  A 501 (-4.0A)
None
9W4  A 502 (-4.1A)
9W4  A 502 (-4.2A)
 1.15A 6ew0G-5w4bA:
6.1		 6ew0G-5w4bA:
10.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5way TRANSCRIPTIONAL
ACTIVATOR

(Streptococcus
pneumoniae) 		PF05043
(Mga)
PF08270
(PRD_Mga)
PF08280
(HTH_Mga) 		5 HIS A  48
ALA A  52
PHE A  53
LEU A  16
ARG A  11
 None
 1.12A 6ew0G-5wayA:
undetectable		 6ew0G-5wayA:
10.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5way TRANSCRIPTIONAL
ACTIVATOR

(Streptococcus
pneumoniae) 		PF05043
(Mga)
PF08270
(PRD_Mga)
PF08280
(HTH_Mga) 		5 LEU A  15
ALA A  52
PHE A  53
LEU A  16
ARG A  11
 None
 1.09A 6ew0G-5wayA:
undetectable		 6ew0G-5wayA:
10.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y59 ATP-DEPENDENT DNA
HELICASE II SUBUNIT
2

(Saccharomyces
cerevisiae) 		no annotation 5 VAL B 113
ASP B 116
LEU B  87
LEU B  29
ARG B  86
 None
 1.11A 6ew0G-5y59B:
3.2		 6ew0G-5y59B:
16.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y6q ALDEHYDE OXIDASE
MEDIUM SUBUNIT

(Methylobacillus
sp. KY4400) 		no annotation 5 LEU B  59
ALA B  87
SER B 228
LEU B  77
LEU B 170
 None
 0.84A 6ew0G-5y6qB:
undetectable		 6ew0G-5y6qB:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yl7 PSEUDOALTEROMONAS
ARCTICA PAMC 21717

(Pseudoalteromonas
arctica) 		no annotation 5 VAL A 181
ASP A 310
LEU A 167
LEU A 165
LEU A 454
 None
 1.00A 6ew0G-5yl7A:
undetectable		 6ew0G-5yl7A:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ap6 PROBABLE
STRIGOLACTONE
ESTERASE DAD2

(Petunia x
hybrida) 		no annotation 5 ASP A  77
LEU A 118
ALA A 105
PHE A 113
LEU A 116
 None
 1.08A 6ew0G-6ap6A:
undetectable		 6ew0G-6ap6A:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1biy LACTOFERRIN

(Bubalus bubalis) 		PF00405
(Transferrin) 		4 LEU A 451
LEU A 589
THR A 577
ARG A 566
 None
 0.92A 6ew0G-1biyA:
undetectable		 6ew0G-1biyA:
7.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gkr NON-ATP DEPENDENT
L-SELECTIVE
HYDANTOINASE

(Paenarthrobacter
aurescens) 		PF01979
(Amidohydro_1) 		4 LEU A 360
LEU A 392
THR A 347
ARG A 406
 None
 1.11A 6ew0G-1gkrA:
undetectable		 6ew0G-1gkrA:
11.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1htj KIAA0380

(Homo sapiens) 		PF09128
(RGS-like) 		4 LEU F 324
THR F 478
PRO F 374
ARG F 376
 None
 1.08A 6ew0G-1htjF:
undetectable		 6ew0G-1htjF:
15.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i7q ANTHRANILATE
SYNTHASE

(Serratia
marcescens) 		PF00425
(Chorismate_bind)
PF04715
(Anth_synt_I_N) 		4 LEU A 127
LEU A 154
THR A  67
ARG A 169
 None
 0.98A 6ew0G-1i7qA:
0.0		 6ew0G-1i7qA:
10.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iq0 ARGINYL-TRNA
SYNTHETASE

(Thermus
thermophilus) 		PF00750
(tRNA-synt_1d)
PF03485
(Arg_tRNA_synt_N)
PF05746
(DALR_1) 		4 LEU A 160
THR A 152
PRO A 337
ARG A 322
 None
 0.95A 6ew0G-1iq0A:
0.3		 6ew0G-1iq0A:
9.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jct GLUCARATE
DEHYDRATASE

(Escherichia
coli) 		PF13378
(MR_MLE_C) 		4 LEU A 378
THR A  37
PRO A 163
ARG A 157
 None
 0.97A 6ew0G-1jctA:
3.1		 6ew0G-1jctA:
11.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kgs DNA BINDING RESPONSE
REGULATOR D

(Thermotoga
maritima) 		PF00072
(Response_reg)
PF00486
(Trans_reg_C) 		4 LEU A 110
LEU A  14
THR A  81
PRO A  57
 None
 1.06A 6ew0G-1kgsA:
0.2		 6ew0G-1kgsA:
16.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lu4 SOLUBLE SECRETED
ANTIGEN MPT53

(Mycobacterium
tuberculosis) 		PF00578
(AhpC-TSA) 		4 LEU A1079
LEU A1012
THR A1033
ARG A1094
 None
 1.03A 6ew0G-1lu4A:
1.8		 6ew0G-1lu4A:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n7d LOW-DENSITY
LIPOPROTEIN RECEPTOR

(Homo sapiens) 		PF00057
(Ldl_recept_a)
PF00058
(Ldl_recept_b)
PF07645
(EGF_CA)
PF14670
(FXa_inhibition) 		4 LEU A 661
THR A 489
PRO A 498
ARG A 499
 None
 0.93A 6ew0G-1n7dA:
undetectable		 6ew0G-1n7dA:
8.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p43 ENOLASE 1

(Saccharomyces
cerevisiae) 		PF00113
(Enolase_C)
PF03952
(Enolase_N) 		4 LEU A 115
LEU A 133
THR A 381
PRO A 147
 None
 1.06A 6ew0G-1p43A:
0.4		 6ew0G-1p43A:
12.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q0z ACLACINOMYCIN
METHYLESTERASE

(Streptomyces
purpurascens) 		PF00561
(Abhydrolase_1) 		4 LEU A  88
LEU A 119
ARG A 267
ARG A 295
 None
 1.08A 6ew0G-1q0zA:
2.8		 6ew0G-1q0zA:
14.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qi9 PROTEIN (VANADIUM
BROMOPEROXIDASE)

(Ascophyllum
nodosum) 		no annotation 4 LEU A 380
LEU A 146
THR A 397
ARG A 349
 None
None
None
VO4  A 600 (-2.7A)
 1.05A 6ew0G-1qi9A:
undetectable		 6ew0G-1qi9A:
9.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qzg PROTECTION OF
TELOMERES PROTEIN 1

(Schizosaccharomyces
pombe) 		PF02765
(POT1) 		4 LEU A  45
LEU A  87
THR A 111
ARG A 116
 None
 1.08A 6ew0G-1qzgA:
undetectable		 6ew0G-1qzgA:
14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tjr BX1

(Zea mays) 		PF00290
(Trp_syntA) 		4 LEU A 177
LEU A 135
ARG A 155
ARG A 333
 None
 0.93A 6ew0G-1tjrA:
undetectable		 6ew0G-1tjrA:
13.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vkz PHOSPHORIBOSYLAMINE-
-GLYCINE LIGASE

(Thermotoga
maritima) 		PF01071
(GARS_A)
PF02843
(GARS_C)
PF02844
(GARS_N) 		4 LEU A 338
LEU A 321
PRO A 281
ARG A  14
 None
 0.89A 6ew0G-1vkzA:
1.4		 6ew0G-1vkzA:
12.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vzo RIBOSOMAL PROTEIN S6
KINASE ALPHA 5

(Homo sapiens) 		PF00069
(Pkinase) 		4 LEU A 105
LEU A 129
THR A  87
ARG A 209
 None
 1.06A 6ew0G-1vzoA:
undetectable		 6ew0G-1vzoA:
13.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wn9 THE HYPOTHETICAL
PROTEIN (TT1805)

(Thermus
thermophilus) 		PF11432
(DUF3197) 		4 LEU A 102
LEU A  58
THR A  35
ARG A  88
 None
 1.07A 6ew0G-1wn9A:
undetectable		 6ew0G-1wn9A:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wwl MONOCYTE
DIFFERENTIATION
ANTIGEN CD14

(Mus musculus) 		no annotation 4 LEU A 128
LEU A  91
THR A  76
ARG A  81
 None
 1.03A 6ew0G-1wwlA:
undetectable		 6ew0G-1wwlA:
12.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wyt GLYCINE
DEHYDROGENASE
SUBUNIT 2
(P-PROTEIN)

(Thermus
thermophilus) 		PF02347
(GDC-P) 		4 LEU B  71
THR B  67
ARG B  60
PRO B 453
 None
 1.03A 6ew0G-1wytB:
2.6		 6ew0G-1wytB:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xv9 ORPHAN NUCLEAR
RECEPTOR NR1I3

(Homo sapiens) 		PF00104
(Hormone_recep) 		4 LEU B 242
LEU B 206
THR B 225
ARG B 136
 None
 1.09A 6ew0G-1xv9B:
undetectable		 6ew0G-1xv9B:
15.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cge ATP-DEPENDENT
MOLECULAR CHAPERONE
HSP82

(Saccharomyces
cerevisiae) 		PF00183
(HSP90) 		4 LEU A 558
LEU A 651
THR A 612
PRO A 486
 None
 0.82A 6ew0G-2cgeA:
undetectable		 6ew0G-2cgeA:
12.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ch1 3-HYDROXYKYNURENINE
TRANSAMINASE

(Anopheles
gambiae) 		PF00266
(Aminotran_5) 		4 LEU A 176
LEU A 135
THR A 150
ARG A 311
 None
 1.11A 6ew0G-2ch1A:
undetectable		 6ew0G-2ch1A:
11.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d0o DIOL
DEHYDRATASE-REACTIVA
TING FACTOR LARGE
SUBUNIT
DIOL
DEHYDRATASE-REACTIVA
TING FACTOR SMALL
SUBUNIT

(Klebsiella
oxytoca) 		PF02288
(Dehydratase_MU)
PF08841
(DDR) 		4 LEU A 353
LEU A 450
ARG A 496
ARG B 112
 None
 0.99A 6ew0G-2d0oA:
undetectable		 6ew0G-2d0oA:
8.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gwc GLUTAMATE CYSTEINE
LIGASE

(Brassica juncea) 		PF04107
(GCS2) 		4 LEU A 476
LEU A 274
ARG A 433
ARG A 387
 None
None
None
BSC  A   2 (-2.6A)
 1.09A 6ew0G-2gwcA:
undetectable		 6ew0G-2gwcA:
11.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gwr DNA-BINDING RESPONSE
REGULATOR MTRA

(Mycobacterium
tuberculosis) 		PF00072
(Response_reg)
PF00486
(Trans_reg_C) 		4 LEU A 112
LEU A  17
THR A  83
PRO A  60
 None
 1.04A 6ew0G-2gwrA:
undetectable		 6ew0G-2gwrA:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hnh DNA POLYMERASE III
ALPHA SUBUNIT

(Escherichia
coli) 		PF02811
(PHP)
PF07733
(DNA_pol3_alpha)
PF14579
(HHH_6) 		4 LEU A 249
LEU A 182
THR A 199
ARG A 141
 None
 1.10A 6ew0G-2hnhA:
undetectable		 6ew0G-2hnhA:
6.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mcp IGA-KAPPA MCPC603
FAB (HEAVY CHAIN)

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 LEU H  18
THR H 117
PRO H 128
ARG H 126
 None
 1.05A 6ew0G-2mcpH:
undetectable		 6ew0G-2mcpH:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nzx ALPHA1,3-FUCOSYLTRAN
SFERASE

(Helicobacter
pylori) 		PF00852
(Glyco_transf_10) 		4 LEU A  69
LEU A  51
THR A 337
ARG A 121
 None
 1.10A 6ew0G-2nzxA:
undetectable		 6ew0G-2nzxA:
11.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o1v ENDOPLASMIN

(Canis lupus) 		PF00183
(HSP90)
PF02518
(HATPase_c) 		4 LEU A 619
THR A 684
ARG A 724
PRO A 553
 None
 1.05A 6ew0G-2o1vA:
undetectable		 6ew0G-2o1vA:
9.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qqk NEUROPILIN-2

(Homo sapiens) 		PF00431
(CUB)
PF00754
(F5_F8_type_C) 		4 LEU A 441
LEU A 590
THR A 337
PRO A 271
 None
 0.95A 6ew0G-2qqkA:
undetectable		 6ew0G-2qqkA:
10.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qts ACID-SENSING ION
CHANNEL

(Gallus gallus) 		PF00858
(ASC) 		4 LEU A 219
LEU A 223
THR A  92
ARG A 100
 None
 1.00A 6ew0G-2qtsA:
undetectable		 6ew0G-2qtsA:
9.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r0l HEPATOCYTE GROWTH
FACTOR ACTIVATOR

(Homo sapiens) 		PF00089
(Trypsin)
no annotation 		4 LEU A 105
LEU A 123
THR A  49
PRO B 388
 None
 1.02A 6ew0G-2r0lA:
undetectable		 6ew0G-2r0lA:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r0l HEPATOCYTE GROWTH
FACTOR ACTIVATOR

(Homo sapiens) 		PF00089
(Trypsin)
no annotation 		4 LEU A 123
THR A  49
ARG B 395
ARG B 390
 None
 1.08A 6ew0G-2r0lA:
undetectable		 6ew0G-2r0lA:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rkv TRICHOTHECENE
3-O-ACETYLTRANSFERAS
E

(Fusarium
graminearum) 		PF02458
(Transferase) 		4 LEU A 171
LEU A 392
THR A 151
ARG A  90
 None
 0.82A 6ew0G-2rkvA:
undetectable		 6ew0G-2rkvA:
11.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xnd ATP SYNTHASE SUBUNIT
DELTA, MITOCHONDRIAL
ATP SYNTHASE SUBUNIT
EPSILON,
MITOCHONDRIAL

(Bos taurus) 		PF02823
(ATP-synt_DE_N)
PF04627
(ATP-synt_Eps) 		4 LEU I  26
LEU H 141
THR H  99
PRO H  39
 None
 1.06A 6ew0G-2xndI:
undetectable		 6ew0G-2xndI:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y9y ISWI ONE COMPLEX
PROTEIN 3

(Saccharomyces
cerevisiae) 		PF15612
(WHIM1) 		4 LEU B 530
LEU B 535
THR B 148
ARG B 542
 None
 1.05A 6ew0G-2y9yB:
undetectable		 6ew0G-2y9yB:
8.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ycb CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR

(Methanothermobacter
thermautotrophicus) 		PF07521
(RMMBL)
PF10996
(Beta-Casp)
PF16661
(Lactamase_B_6)
PF17214
(KH_7) 		4 LEU A 196
LEU A 338
THR A 350
PRO A 594
 None
 0.91A 6ew0G-2ycbA:
undetectable		 6ew0G-2ycbA:
9.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yx0 RADICAL SAM ENZYME

(Pyrococcus
horikoshii) 		PF04055
(Radical_SAM)
PF08608
(Wyosine_form) 		4 LEU A 231
LEU A 198
THR A 180
PRO A  76
 None
 1.09A 6ew0G-2yx0A:
3.0		 6ew0G-2yx0A:
12.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z9v ASPARTATE
AMINOTRANSFERASE

(Mesorhizobium
loti) 		PF00266
(Aminotran_5) 		4 LEU A 292
LEU A 320
THR A 363
ARG A   3
 None
 1.10A 6ew0G-2z9vA:
undetectable		 6ew0G-2z9vA:
12.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zbw THIOREDOXIN
REDUCTASE

(Thermus
thermophilus) 		PF07992
(Pyr_redox_2) 		4 LEU A 237
LEU A 156
THR A 210
ARG A 205
 None
 0.94A 6ew0G-2zbwA:
undetectable		 6ew0G-2zbwA:
12.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3af5 PUTATIVE
UNCHARACTERIZED
PROTEIN PH1404

(Pyrococcus
horikoshii) 		PF07521
(RMMBL)
PF10996
(Beta-Casp)
PF16661
(Lactamase_B_6)
PF17214
(KH_7) 		4 LEU A 205
LEU A 353
THR A 365
PRO A 609
 None
 1.00A 6ew0G-3af5A:
undetectable		 6ew0G-3af5A:
8.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aov PUTATIVE
UNCHARACTERIZED
PROTEIN PH0207

(Pyrococcus
horikoshii) 		PF00155
(Aminotran_1_2) 		4 LEU A 318
LEU A 111
THR A 266
PRO A 204
 None
None
PLP  A 429 (-3.1A)
None
 1.06A 6ew0G-3aovA:
undetectable		 6ew0G-3aovA:
12.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cai POSSIBLE
AMINOTRANSFERASE

(Mycobacterium
tuberculosis) 		PF00266
(Aminotran_5) 		4 LEU A 394
LEU A 307
THR A 375
PRO A 323
 None
 0.92A 6ew0G-3caiA:
undetectable		 6ew0G-3caiA:
11.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e9d ZGC:56074

(Danio rerio) 		PF00300
(His_Phos_1) 		4 LEU A 139
LEU A 194
THR A   7
PRO A 161
 None
 0.99A 6ew0G-3e9dA:
undetectable		 6ew0G-3e9dA:
15.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g87 MALONYL COA-ACYL
CARRIER PROTEIN
TRANSACYLASE

(Burkholderia
pseudomallei) 		PF00698
(Acyl_transf_1) 		4 LEU A  32
LEU A 100
THR A  73
PRO A  85
 None
 1.06A 6ew0G-3g87A:
undetectable		 6ew0G-3g87A:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gl5 PUTATIVE DSBA
OXIDOREDUCTASE
SCO1869

(Streptomyces
coelicolor) 		PF01323
(DSBA) 		4 LEU A 157
LEU A 117
THR A  98
ARG A  89
 None
 1.08A 6ew0G-3gl5A:
undetectable		 6ew0G-3gl5A:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h5q PYRIMIDINE-NUCLEOSID
E PHOSPHORYLASE

(Staphylococcus
aureus) 		PF00591
(Glycos_transf_3)
PF02885
(Glycos_trans_3N)
PF07831
(PYNP_C) 		4 LEU A 260
LEU A 253
THR A  92
ARG A 112
 None
None
SO4  A 436 (-3.0A)
None
 1.09A 6ew0G-3h5qA:
undetectable		 6ew0G-3h5qA:
10.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hjc HEAT SHOCK PROTEIN
83-1

(Leishmania
major) 		PF00183
(HSP90) 		4 LEU A 287
LEU A 379
THR A 341
PRO A 214
 None
 1.02A 6ew0G-3hjcA:
undetectable		 6ew0G-3hjcA:
10.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hrd NICOTINATE
DEHYDROGENASE LARGE
MOLYBDOPTERIN
SUBUNIT
NICOTINATE
DEHYDROGENASE MEDIUM
MOLYBDOPTERIN
SUBUNIT

(Eubacterium
barkeri) 		PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2) 		4 LEU B  91
THR B  18
PRO B 290
ARG A 351
 None
NIO  B5661 (-3.9A)
None
MCN  B 921 ( 4.0A)
 1.10A 6ew0G-3hrdB:
undetectable		 6ew0G-3hrdB:
14.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hrp UNCHARACTERIZED
PROTEIN

(Bacteroides
thetaiotaomicron) 		PF01833
(TIG) 		4 LEU A 254
THR A 216
PRO A 173
ARG A 176
 None
EDO  A  15 (-3.2A)
None
None
 1.03A 6ew0G-3hrpA:
undetectable		 6ew0G-3hrpA:
12.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3htz ALANYL-TRNA
SYNTHETASE

(Aquifex
aeolicus) 		PF01411
(tRNA-synt_2c) 		4 LEU A  68
THR A 277
ARG A 301
ARG A 267
 None
 1.01A 6ew0G-3htzA:
undetectable		 6ew0G-3htzA:
14.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iz3 STRUCTURAL PROTEIN
VP1
VIRAL STRUCTURAL
PROTEIN 5

(Cypovirus 1) 		no annotation 4 LEU D  35
LEU D 189
ARG B1053
ARG D 265
 None
 1.01A 6ew0G-3iz3D:
undetectable		 6ew0G-3iz3D:
14.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j2s COAGULATION FACTOR
VIII LIGHT CHAIN

(Homo sapiens) 		PF00754
(F5_F8_type_C)
PF07731
(Cu-oxidase_2) 		4 LEU B2306
LEU B2178
THR B2237
ARG B2147
 None
 1.09A 6ew0G-3j2sB:
undetectable		 6ew0G-3j2sB:
8.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3keb PROBABLE THIOL
PEROXIDASE

(Chromobacterium
violaceum) 		no annotation 4 LEU A  68
LEU A  94
THR A  53
ARG A 113
 None
 1.03A 6ew0G-3kebA:
undetectable		 6ew0G-3kebA:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l12 PUTATIVE
GLYCEROPHOSPHORYL
DIESTER
PHOSPHODIESTERASE

(Ruegeria
pomeroyi) 		PF03009
(GDPD) 		4 LEU A 207
LEU A 146
THR A 272
PRO A 297
 UNL  A 317 ( 4.5A)
None
None
None
 1.05A 6ew0G-3l12A:
undetectable		 6ew0G-3l12A:
13.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l8m PROBABLE THIAMINE
PYROPHOSPHOKINASE

(Staphylococcus
saprophyticus) 		PF04263
(TPK_catalytic)
PF04265
(TPK_B1_binding) 		4 LEU A  78
LEU A 113
THR A  99
ARG A 208
 None
 0.95A 6ew0G-3l8mA:
undetectable		 6ew0G-3l8mA:
15.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ldt OUTER MEMBRANE
PROTEIN, OMPA FAMILY
PROTEIN

(Legionella
pneumophila) 		PF00691
(OmpA) 		4 LEU A 155
LEU A 109
THR A 124
ARG A 227
 None
 1.09A 6ew0G-3ldtA:
undetectable		 6ew0G-3ldtA:
17.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lop SUBSTRATE BINDING
PERIPLASMIC PROTEIN

(Ralstonia
solanacearum) 		PF13458
(Peripla_BP_6) 		4 LEU A 119
THR A 109
ARG A 339
PRO A 104
 None
 1.01A 6ew0G-3lopA:
undetectable		 6ew0G-3lopA:
12.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lxq UNCHARACTERIZED
PROTEIN VP1736

(Vibrio
parahaemolyticus) 		PF00884
(Sulfatase) 		4 LEU A 287
THR A 548
PRO A 344
ARG A 334
 None
None
None
CL  A   1 (-4.5A)
 1.07A 6ew0G-3lxqA:
undetectable		 6ew0G-3lxqA:
11.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mzs CHOLESTEROL
SIDE-CHAIN CLEAVAGE
ENZYME

(Bos taurus) 		PF00067
(p450) 		4 LEU A 300
THR A 434
PRO A 398
ARG A 400
 None
 0.96A 6ew0G-3mzsA:
undetectable		 6ew0G-3mzsA:
12.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n0g ISOPRENE SYNTHASE

(Populus tremula
x Populus alba) 		PF01397
(Terpene_synth)
PF03936
(Terpene_synth_C) 		4 LEU A 386
LEU A 450
THR A 342
ARG A 331
 None
 1.01A 6ew0G-3n0gA:
undetectable		 6ew0G-3n0gA:
9.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3na0 CHOLESTEROL
SIDE-CHAIN CLEAVAGE
ENZYME,
MITOCHONDRIAL

(Homo sapiens) 		PF00067
(p450) 		4 LEU A 339
THR A 473
PRO A 437
ARG A 439
 None
 0.98A 6ew0G-3na0A:
undetectable		 6ew0G-3na0A:
11.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nhz TWO COMPONENT SYSTEM
TRANSCRIPTIONAL
REGULATOR MTRA

(Mycobacterium
tuberculosis) 		PF00072
(Response_reg) 		4 LEU A 112
LEU A  17
THR A  83
PRO A  60
 None
 0.95A 6ew0G-3nhzA:
undetectable		 6ew0G-3nhzA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nwr A RUBISCO-LIKE
PROTEIN

(Paraburkholderia
fungorum) 		PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N) 		4 LEU A 307
LEU A  15
THR A 109
ARG A  58
 None
 1.06A 6ew0G-3nwrA:
undetectable		 6ew0G-3nwrA:
11.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nxl GLUCARATE
DEHYDRATASE

(Burkholderia
lata) 		PF13378
(MR_MLE_C) 		4 LEU A 398
THR A  41
PRO A 183
ARG A 177
 None
 1.08A 6ew0G-3nxlA:
2.3		 6ew0G-3nxlA:
10.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ohu TRANSCRIPTION
REGULATOR PROTEIN
BACH2

(Homo sapiens) 		PF00651
(BTB) 		4 LEU A  55
LEU A  78
THR A  40
ARG A  45
 None
 1.07A 6ew0G-3ohuA:
undetectable		 6ew0G-3ohuA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pls MACROPHAGE-STIMULATI
NG PROTEIN RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LEU A1300
LEU A1306
THR A1254
ARG A1245
 None
 1.10A 6ew0G-3plsA:
undetectable		 6ew0G-3plsA:
15.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r3s OXIDOREDUCTASE

(Salmonella
enterica) 		PF13561
(adh_short_C2) 		4 LEU A 118
LEU A 129
THR A 168
ARG A 223
 None
 1.09A 6ew0G-3r3sA:
undetectable		 6ew0G-3r3sA:
13.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rpx COMPLEMENT COMPONENT
1 Q
SUBCOMPONENT-BINDING
PROTEIN

(Homo sapiens) 		PF02330
(MAM33) 		4 LEU A 111
LEU A 256
THR A 130
ARG A 207
 None
 1.09A 6ew0G-3rpxA:
undetectable		 6ew0G-3rpxA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s5n 4-HYDROXY-2-OXOGLUTA
RATE ALDOLASE,
MITOCHONDRIAL

(Homo sapiens) 		PF00701
(DHDPS) 		4 LEU A 288
LEU A  64
THR A  44
ARG A  97
 None
 1.08A 6ew0G-3s5nA:
undetectable		 6ew0G-3s5nA:
14.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3skd PUTATIVE
UNCHARACTERIZED
PROTEIN TTHB187

(Thermus
thermophilus) 		no annotation 4 LEU A 230
LEU A 176
THR A  28
ARG A 196
 None
 1.08A 6ew0G-3skdA:
undetectable		 6ew0G-3skdA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tch PERIPLASMIC
OLIGOPEPTIDE-BINDING
PROTEIN

(Escherichia
coli) 		PF00496
(SBP_bac_5) 		4 LEU A 499
LEU A 353
THR A 450
PRO A 529
 None
 1.04A 6ew0G-3tchA:
undetectable		 6ew0G-3tchA:
9.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u9s METHYLCROTONYL-COA
CARBOXYLASE,
ALPHA-SUBUNIT

(Pseudomonas
aeruginosa) 		PF00289
(Biotin_carb_N)
PF00364
(Biotin_lipoyl)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		4 LEU A 612
THR A 458
PRO A 391
ARG A 464
 None
 1.08A 6ew0G-3u9sA:
undetectable		 6ew0G-3u9sA:
9.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w9s OMPR FAMILY RESPONSE
REGULATOR IN
TWO-COMPONENT
REGULATORY SYSTEM
WITH BASS

(Klebsiella
pneumoniae) 		PF00072
(Response_reg) 		4 LEU A 108
LEU A  12
THR A  79
PRO A  55
 None
None
BEF  A 201 (-3.7A)
None
 1.01A 6ew0G-3w9sA:
undetectable		 6ew0G-3w9sA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wrc GALLATE DIOXYGENASE

(Sphingomonas
paucimobilis) 		PF02900
(LigB)
PF07746
(LigA) 		4 LEU A  99
LEU A 169
THR A  52
ARG A 247
 None
 0.85A 6ew0G-3wrcA:
undetectable		 6ew0G-3wrcA:
10.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bg2 PATF

(Prochloron
didemni) 		no annotation 4 LEU A  87
LEU A 181
THR A 121
ARG A 239
 None
 1.04A 6ew0G-4bg2A:
undetectable		 6ew0G-4bg2A:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bqi ALPHA-GLUCAN
PHOSPHORYLASE 2,
CYTOSOLIC

(Arabidopsis
thaliana) 		PF00343
(Phosphorylase) 		4 LEU A 309
THR A 345
ARG A 400
ARG A 411
 None
None
MLR  A 951 (-2.9A)
MLR  A 951 (-4.1A)
 1.01A 6ew0G-4bqiA:
undetectable		 6ew0G-4bqiA:
7.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4czb NA(+)/H(+)
ANTIPORTER 1

(Methanocaldococcus
jannaschii) 		PF00999
(Na_H_Exchanger) 		4 LEU A 187
LEU A  98
THR A 168
ARG A 320
 None
 1.08A 6ew0G-4czbA:
undetectable		 6ew0G-4czbA:
11.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fdd TRANSPORTIN-1

(Homo sapiens) 		PF03810
(IBN_N)
PF13513
(HEAT_EZ) 		4 LEU A 293
LEU A 304
THR A 282
ARG A 232
 None
 1.05A 6ew0G-4fddA:
1.9		 6ew0G-4fddA:
6.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fim LACTOTRANSFERRIN

(Bos taurus) 		PF00405
(Transferrin) 		4 LEU A 451
LEU A 589
THR A 577
ARG A 566
 GOL  A 712 ( 4.7A)
None
None
NAG  A 710 ( 4.7A)
 1.02A 6ew0G-4fimA:
undetectable		 6ew0G-4fimA:
12.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g2t SSFS6

(Streptomyces
sp. SF2575) 		PF00201
(UDPGT)
PF06722
(DUF1205) 		4 LEU A 237
LEU A 245
THR A 218
PRO A 307
 None
 1.06A 6ew0G-4g2tA:
undetectable		 6ew0G-4g2tA:
11.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g6t TYPE III CHAPERONE
PROTEIN SHCA
TYPE III EFFECTOR
HOPA1

(Pseudomonas
syringae group
genomosp. 3) 		PF05932
(CesT)
no annotation 		4 LEU B  30
LEU A  42
THR A 107
ARG A  50
 None
 1.01A 6ew0G-4g6tB:
undetectable		 6ew0G-4g6tB:
25.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4glp MONOCYTE
DIFFERENTIATION
ANTIGEN CD14

(Homo sapiens) 		PF13516
(LRR_6) 		4 LEU A 164
LEU A 172
THR A 122
ARG A 117
 None
 1.06A 6ew0G-4glpA:
undetectable		 6ew0G-4glpA:
12.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gyp GLUCARATE
DEHYDRATASE-RELATED
PROTEIN

(Escherichia
coli) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 LEU C 377
THR C  36
PRO C 162
ARG C 156
 None
 1.04A 6ew0G-4gypC:
undetectable		 6ew0G-4gypC:
10.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hn8 D-GLUCARATE
DEHYDRATASE

(Pseudomonas
mendocina) 		PF13378
(MR_MLE_C) 		4 LEU A 395
THR A  39
PRO A 180
ARG A 174
 None
 1.05A 6ew0G-4hn8A:
undetectable		 6ew0G-4hn8A:
9.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hst GLUTARYL-7-AMINOCEPH
ALOSPORANIC ACID
ACYLASE ALPHA CHAIN
GLUTARYL-7-AMINOCEPH
ALOSPORANIC ACID
ACYLASE BETA CHAIN

(Pseudomonas) 		PF01804
(Penicil_amidase) 		4 LEU B 399
LEU B 390
THR B 344
ARG A 190
 None
 1.01A 6ew0G-4hstB:
undetectable		 6ew0G-4hstB:
11.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hyr GLUCARATE
DEHYDRATASE

(Acidaminococcus
intestini) 		PF13378
(MR_MLE_C) 		4 LEU A 374
THR A  32
PRO A 159
ARG A 153
 None
 0.99A 6ew0G-4hyrA:
undetectable		 6ew0G-4hyrA:
11.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i0k CD276 ANTIGEN

(Mus musculus) 		PF07686
(V-set)
PF13927
(Ig_3) 		4 LEU A 212
LEU A 208
THR A 217
PRO A 145
 None
None
SO4  A 307 (-4.4A)
None
 0.92A 6ew0G-4i0kA:
undetectable		 6ew0G-4i0kA:
16.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4il1 CALMODULIN,
CALCINEURIN SUBUNIT
B TYPE 1,
SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2B
CATALYTIC SUBUNIT
ALPHA ISOFORM

(Rattus
norvegicus) 		PF00149
(Metallophos)
PF13499
(EF-hand_7) 		4 LEU A 466
THR A 476
PRO A 374
ARG A 375
 None
 1.08A 6ew0G-4il1A:
undetectable		 6ew0G-4il1A:
7.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kbx UNCHARACTERIZED
PROTEIN YHFX

(Escherichia
coli) 		PF01168
(Ala_racemase_N) 		4 LEU A  45
LEU A  58
THR A 260
ARG A  65
 None
 1.05A 6ew0G-4kbxA:
undetectable		 6ew0G-4kbxA:
13.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ld7 DIMETHYLALLYL
TRYPTOPHAN SYNTHASE

(Aspergillus
fischeri) 		PF11991
(Trp_DMAT) 		4 LEU A 360
LEU A 318
THR A 424
PRO A 354
 NA  A 502 (-4.5A)
None
None
None
 1.10A 6ew0G-4ld7A:
undetectable		 6ew0G-4ld7A:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o6x ANKYRIN-3

(Homo sapiens) 		PF00531
(Death) 		4 LEU A  26
LEU A  15
THR A  69
ARG A   3
 None
 1.07A 6ew0G-4o6xA:
undetectable		 6ew0G-4o6xA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p69 ISOCITRATE
DEHYDROGENASE
KINASE/PHOSPHATASE

(Escherichia
coli) 		PF06315
(AceK) 		5 LEU A 213
LEU A 153
THR A 181
ARG A 171
ARG A 568
 None
 1.43A 6ew0G-4p69A:
undetectable		 6ew0G-4p69A:
9.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pag PERIPLASMIC BINDING
PROTEIN

(Sulfurospirillum
deleyianum) 		PF01497
(Peripla_BP_2) 		4 LEU A 340
LEU A 295
PRO A 288
ARG A 287
 None
 0.90A 6ew0G-4pagA:
undetectable		 6ew0G-4pagA:
13.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ptz FMN REDUCTASE SSUE

(Escherichia
coli) 		no annotation 4 LEU C  63
LEU C  87
THR C   4
PRO C  74
 None
None
None
FMN  C 201 (-4.1A)
 1.01A 6ew0G-4ptzC:
undetectable		 6ew0G-4ptzC:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r0b GLYCODELIN

(Homo sapiens) 		PF00061
(Lipocalin) 		4 LEU A  15
LEU A 122
THR A  93
ARG A 138
 None
 1.03A 6ew0G-4r0bA:
undetectable		 6ew0G-4r0bA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v2x ENDO-BETA-1,4-GLUCAN
ASE (CELLULASE B)

(Bacillus
halodurans) 		PF00150
(Cellulase)
PF03442
(CBM_X2) 		4 LEU A 462
LEU A 483
THR A 538
ARG A 265
 None
 1.10A 6ew0G-4v2xA:
undetectable		 6ew0G-4v2xA:
9.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yeb FIBRONECTIN LEUCINE
RICH TRANSMEMBRANE
PROTEIN 3

(Mus musculus) 		PF13855
(LRR_8) 		4 LEU B 195
LEU B 232
THR B 189
ARG B 163
 None
 1.01A 6ew0G-4yebB:
undetectable		 6ew0G-4yebB:
11.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ysw XANTHINE
DEHYDROGENASE/OXIDAS
E

(Rattus
norvegicus) 		PF00111
(Fer2)
PF00941
(FAD_binding_5)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2)
PF03450
(CO_deh_flav_C) 		4 LEU A 493
LEU A 466
THR A 462
ARG A 383
 None
 0.96A 6ew0G-4yswA:
undetectable		 6ew0G-4yswA:
5.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zqv CDII IMMUNITY
PROTEIN

(Yersinia
kristensenii) 		PF07262
(CdiI) 		4 LEU A 156
LEU A  58
THR A 118
ARG A  29
 None
 1.09A 6ew0G-4zqvA:
undetectable		 6ew0G-4zqvA:
18.42