SIMILAR PATTERNS OF AMINO ACIDS FOR 6EW0_F_TA1F502_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bg5 FUSION PROTEIN OF
ALPHA-NA,K-ATPASE
WITH GLUTATHIONE
S-TRANSFERASE

(Rattus
norvegicus) 		PF02798
(GST_N)
PF14497
(GST_C_3) 		5 LEU A 137
ASP A 152
ALA A 158
LEU A 176
ARG A 136
 None
 1.15A 6ew0F-1bg5A:
undetectable		 6ew0F-1bg5A:
14.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1biy LACTOFERRIN

(Bubalus bubalis) 		PF00405
(Transferrin) 		5 GLU A 211
LEU A 106
ALA A  94
LEU A 232
ARG A 236
 None
 1.22A 6ew0F-1biyA:
undetectable		 6ew0F-1biyA:
7.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1epz DTDP-6-DEOXY-D-XYLO-
4-HEXULOSE
3,5-EPIMERASE

(Methanothermobacter
thermautotrophicus) 		PF00908
(dTDP_sugar_isom) 		5 VAL A  85
ASP A  84
ASP A 172
LEU A 166
LEU A 125
 None
None
TYD  A2187 ( 4.4A)
None
None
 1.20A 6ew0F-1epzA:
undetectable		 6ew0F-1epzA:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gff BACTERIOPHAGE G4
CAPSID PROTEINS GPF,
GPG, GPJ

(Escherichia
virus G4) 		PF02305
(Phage_F) 		5 ASP 1 391
GLU 1 392
ASP 1 381
ALA 1 373
SER 1 372
 None
 1.19A 6ew0F-1gff1:
undetectable		 6ew0F-1gff1:
10.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h2b ALCOHOL
DEHYDROGENASE

(Aeropyrum
pernix) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 VAL A  33
ASP A  32
GLU A  31
ARG A  47
LEU A 336
 None
 1.19A 6ew0F-1h2bA:
2.2		 6ew0F-1h2bA:
12.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h8l CARBOXYPEPTIDASE
GP180 RESIDUES
503-882

(Lophonetta
specularioides) 		PF00246
(Peptidase_M14)
PF13620
(CarboxypepD_reg) 		5 VAL A 368
ASP A 369
LEU A 176
LEU A 213
GLN A 297
 None
 1.12A 6ew0F-1h8lA:
undetectable		 6ew0F-1h8lA:
11.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hkk CHITOTRIOSIDASE-1

(Homo sapiens) 		PF00704
(Glyco_hydro_18) 		5 VAL A 243
ASP A 244
LEU A 385
SER A 226
LEU A 381
 None
 1.18A 6ew0F-1hkkA:
undetectable		 6ew0F-1hkkA:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hkw DIAMINOPIMELATE
DECARBOXYLASE

(Mycobacterium
tuberculosis) 		PF00278
(Orn_DAP_Arg_deC)
PF02784
(Orn_Arg_deC_N) 		5 VAL A 166
LEU A 275
ASP A 220
ALA A 227
LEU A 279
 None
 1.09A 6ew0F-1hkwA:
undetectable		 6ew0F-1hkwA:
10.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t6p PHENYLALANINE
AMMONIA-LYASE

(Rhodotorula
toruloides) 		PF00221
(Lyase_aromatic) 		5 LEU A 532
ALA A 701
SER A 704
LEU A 528
LEU A 711
 None
 1.13A 6ew0F-1t6pA:
undetectable		 6ew0F-1t6pA:
7.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t92 GENERAL SECRETION
PATHWAY PROTEIN G

(Klebsiella
pneumoniae) 		PF08334
(T2SSG) 		5 ASP A 125
LEU A  67
SER A 122
LEU A  64
GLN A  62
 None
 1.22A 6ew0F-1t92A:
undetectable		 6ew0F-1t92A:
24.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u0u DIHYDROPINOSYLVIN
SYNTHASE

(Pinus
sylvestris) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		5 VAL A 105
LEU A 153
ALA A 109
LEU A 190
ARG A 159
 None
 1.21A 6ew0F-1u0uA:
undetectable		 6ew0F-1u0uA:
12.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v6c ALKALINE SERINE
PROTEASE

(Pseudoalteromonas
sp. AS-11) 		PF00082
(Peptidase_S8)
PF02225
(PA) 		5 GLU A   2
ASP A  34
HIS A  37
ALA A  75
LEU A 206
 CA  A 503 (-3.4A)
None
None
None
None
 1.24A 6ew0F-1v6cA:
undetectable		 6ew0F-1v6cA:
9.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vf8 SECRETORY PROTEIN

(Mus musculus) 		PF00704
(Glyco_hydro_18) 		5 VAL A 222
ASP A 223
LEU A 366
SER A 205
LEU A 362
 None
 1.18A 6ew0F-1vf8A:
undetectable		 6ew0F-1vf8A:
12.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wb0 CHITOTRIOSIDASE 1

(Homo sapiens) 		PF00704
(Glyco_hydro_18) 		5 VAL A 243
ASP A 244
LEU A 387
SER A 226
LEU A 383
 None
 1.16A 6ew0F-1wb0A:
undetectable		 6ew0F-1wb0A:
11.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y4u CHAPERONE PROTEIN
HTPG

(Escherichia
coli) 		PF00183
(HSP90)
PF02518
(HATPase_c) 		5 GLU A 273
LEU A 278
SER A 328
LEU A 352
GLN A 358
 None
 1.21A 6ew0F-1y4uA:
undetectable		 6ew0F-1y4uA:
10.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a3l AMP DEAMINASE

(Arabidopsis
thaliana) 		PF00962
(A_deaminase) 		5 GLU A 603
ASP A 389
HIS A 391
ALA A 680
LEU A 544
 None
None
ZN  A 840 ( 3.2A)
None
None
 0.98A 6ew0F-2a3lA:
undetectable		 6ew0F-2a3lA:
7.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a7m N-ACYL HOMOSERINE
LACTONE HYDROLASE

(Bacillus
thuringiensis) 		PF00753
(Lactamase_B) 		5 GLU A 127
LEU A 187
SER A 170
LEU A 220
GLN A 162
 None
 1.15A 6ew0F-2a7mA:
undetectable		 6ew0F-2a7mA:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cuk GLYCERATE
DEHYDROGENASE/GLYOXY
LATE REDUCTASE

(Thermus
thermophilus) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		5 ASP A  53
LEU A  22
ALA A  70
LEU A 301
LEU A  66
 None
 1.13A 6ew0F-2cukA:
2.1		 6ew0F-2cukA:
15.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e5a LIPOYLTRANSFERASE 1

(Bos taurus) 		no annotation 5 VAL A 114
LEU A  39
ALA A 110
LEU A  89
ARG A  41
 None
 1.10A 6ew0F-2e5aA:
undetectable		 6ew0F-2e5aA:
15.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g2o MALONYL COA-ACYL
CARRIER PROTEIN
TRANSACYLASE

(Escherichia
coli) 		PF00698
(Acyl_transf_1) 		5 VAL A 100
LEU A  44
ALA A 110
GLN A  14
LEU A  93
 None
None
None
None
SO4  A1001 (-4.3A)
 1.12A 6ew0F-2g2oA:
undetectable		 6ew0F-2g2oA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nbr GAMMA-CRYSTALLIN C

(Homo sapiens) 		PF00030
(Crystall) 		5 ASP A 113
ALA A 163
LEU A 145
ARG A 167
LEU A 104
 None
 1.17A 6ew0F-2nbrA:
undetectable		 6ew0F-2nbrA:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qfc PLCR PROTEIN

(Bacillus
thuringiensis) 		PF01381
(HTH_3) 		5 VAL A 196
ASP A 195
ALA A 233
SER A 231
GLN A 118
 None
 1.23A 6ew0F-2qfcA:
undetectable		 6ew0F-2qfcA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qna IMPORTIN SUBUNIT
BETA-1

(Homo sapiens) 		PF13513
(HEAT_EZ) 		5 VAL A 638
GLU A 637
ASP A 605
LEU A 611
LEU A 673
 None
 1.14A 6ew0F-2qnaA:
undetectable		 6ew0F-2qnaA:
7.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vl7 XPD

(Sulfurisphaera
tokodaii) 		PF06733
(DEAD_2)
PF13307
(Helicase_C_2) 		5 ASP A 307
LEU A 324
ALA A 190
LEU A 333
LEU A 481
 None
 1.23A 6ew0F-2vl7A:
undetectable		 6ew0F-2vl7A:
10.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ybu ACIDIC MAMMALIAN
CHITINASE

(Homo sapiens) 		PF00704
(Glyco_hydro_18) 		5 VAL A 243
ASP A 244
LEU A 387
SER A 226
LEU A 383
 None
 1.16A 6ew0F-2ybuA:
undetectable		 6ew0F-2ybuA:
11.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zgd 3 REPEAT SYNTHETIC
ANKYRIN

(-) 		PF12796
(Ank_2) 		5 VAL A  40
ASP A  38
GLU A  39
LEU A 105
ALA A  32
 None
CD  A 413 ( 2.4A)
CD  A 410 ( 2.1A)
None
None
 1.09A 6ew0F-2zgdA:
undetectable		 6ew0F-2zgdA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bg2 DGTP
TRIPHOSPHOHYDROLASE

(Leeuwenhoekiella
blandensis) 		PF01966
(HD) 		5 VAL A 249
ASP A 117
HIS A 116
ALA A 112
LEU A 168
 None
 1.18A 6ew0F-3bg2A:
undetectable		 6ew0F-3bg2A:
10.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3blx ISOCITRATE
DEHYDROGENASE [NAD]
SUBUNIT 2

(Saccharomyces
cerevisiae) 		PF00180
(Iso_dh) 		5 GLU B  54
LEU B  99
ALA B  73
SER B  76
LEU B 103
 None
 1.12A 6ew0F-3blxB:
undetectable		 6ew0F-3blxB:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d3l ARACHIDONATE
12-LIPOXYGENASE,
12S-TYPE

(Homo sapiens) 		PF00305
(Lipoxygenase) 		5 LEU A 183
SER A 440
ARG A 430
GLN A 427
LEU A 280
 None
 1.23A 6ew0F-3d3lA:
undetectable		 6ew0F-3d3lA:
8.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3goz LEUCINE-RICH
REPEAT-CONTAINING
PROTEIN

(Legionella
pneumophila) 		no annotation 5 ASP A  98
GLU A  99
LEU A 114
SER A  68
LEU A  87
 None
 1.22A 6ew0F-3gozA:
undetectable		 6ew0F-3gozA:
14.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3grn MUTT RELATED PROTEIN

(Methanosarcina
mazei) 		PF00293
(NUDIX) 		5 VAL A  89
LEU A 117
LEU A 113
ARG A 127
LEU A  24
 None
 1.24A 6ew0F-3grnA:
undetectable		 6ew0F-3grnA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hjv MALONYL COA-ACYL
CARRIER PROTEIN
TRANSACYLASE

(Vibrio cholerae) 		PF00698
(Acyl_transf_1) 		5 VAL A 105
LEU A  49
ALA A 115
GLN A  19
LEU A  98
 None
None
None
CL  A 328 (-3.5A)
None
 1.13A 6ew0F-3hjvA:
undetectable		 6ew0F-3hjvA:
13.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hl1 FERRITIN LIKE
PROTEIN

(Caulobacter
vibrioides) 		PF12902
(Ferritin-like) 		5 VAL A 183
LEU A  10
ALA A 194
LEU A 150
GLN A  15
 None
 1.17A 6ew0F-3hl1A:
undetectable		 6ew0F-3hl1A:
14.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3im8 MALONYL ACYL CARRIER
PROTEIN TRANSACYLASE

(Streptococcus
pneumoniae) 		PF00698
(Acyl_transf_1) 		5 VAL A  98
LEU A  44
ALA A 108
GLN A  14
LEU A  91
 None
 1.08A 6ew0F-3im8A:
undetectable		 6ew0F-3im8A:
14.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ku0 RIBOSOME-INACTIVATIN
G PROTEIN GELONIN

(Suregada
multiflora) 		PF00161
(RIP) 		5 VAL A  54
LEU A  40
ASP A  69
LEU A 242
ARG A  41
 None
 1.07A 6ew0F-3ku0A:
undetectable		 6ew0F-3ku0A:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lmd GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE

(Corynebacterium
glutamicum) 		PF00348
(polyprenyl_synt) 		5 VAL A 277
GLU A 273
LEU A 289
SER A 305
LEU A 258
 None
 1.07A 6ew0F-3lmdA:
undetectable		 6ew0F-3lmdA:
10.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oak TRANSCRIPTION FACTOR
IWS1

(Saccharomyces
cerevisiae) 		PF08711
(Med26) 		6 ASP A 163
GLU A 164
LEU A 225
LEU A 242
ARG A 222
LEU A 217
 None
 1.30A 6ew0F-3oakA:
undetectable		 6ew0F-3oakA:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oee ATP SYNTHASE SUBUNIT
ALPHA

(Saccharomyces
cerevisiae) 		PF00006
(ATP-synt_ab)
PF00306
(ATP-synt_ab_C)
PF02874
(ATP-synt_ab_N) 		5 LEU A 273
ASP A 271
ALA A 252
LEU A 307
LEU A 323
 None
MG  A 700 ( 3.6A)
None
None
None
 1.18A 6ew0F-3oeeA:
undetectable		 6ew0F-3oeeA:
11.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pfe SUCCINYL-DIAMINOPIME
LATE DESUCCINYLASE

(Legionella
pneumophila) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		5 ASP A 190
ASP A 168
LEU A 176
GLN A 423
LEU A  92
 ZN  A 501 ( 1.9A)
None
None
GOL  A 519 (-4.7A)
None
 1.24A 6ew0F-3pfeA:
undetectable		 6ew0F-3pfeA:
11.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v65 LOW-DENSITY
LIPOPROTEIN
RECEPTOR-RELATED
PROTEIN 4

(Rattus
norvegicus) 		PF00058
(Ldl_recept_b)
PF14670
(FXa_inhibition) 		5 LEU B 443
ASP B 474
ALA B 495
LEU B 463
LEU B 467
 None
 1.14A 6ew0F-3v65B:
undetectable		 6ew0F-3v65B:
11.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wrc GALLATE DIOXYGENASE

(Sphingomonas
paucimobilis) 		PF02900
(LigB)
PF07746
(LigA) 		5 ASP A 276
LEU A 134
ALA A 185
LEU A 133
LEU A 273
 None
 1.23A 6ew0F-3wrcA:
undetectable		 6ew0F-3wrcA:
10.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a11 DNA EXCISION REPAIR
PROTEIN ERCC-8

(Homo sapiens) 		PF00400
(WD40) 		5 LEU B 226
ALA B 191
SER B 146
LEU B 260
ARG B 270
 None
 1.21A 6ew0F-4a11B:
undetectable		 6ew0F-4a11B:
10.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ags THIOL-DEPENDENT
REDUCTASE 1

(Leishmania
infantum) 		PF13417
(GST_N_3)
PF16865
(GST_C_5) 		5 VAL A 327
LEU A 252
ASP A 302
ALA A 385
LEU A 416
 None
 1.17A 6ew0F-4agsA:
undetectable		 6ew0F-4agsA:
11.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4blp PACKAGING ENZYME P4

(Pseudomonas
phage phi13) 		PF11602
(NTPase_P4) 		5 VAL A 210
ASP A 169
ALA A 200
LEU A  82
LEU A  89
 None
 1.21A 6ew0F-4blpA:
undetectable		 6ew0F-4blpA:
13.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cp6 CHOLINE BINDING
PROTEIN PCPA

(Streptococcus
pneumoniae) 		PF13306
(LRR_5) 		5 GLU A 157
LEU A 217
ALA A 182
LEU A 192
LEU A 175
 None
 1.25A 6ew0F-4cp6A:
undetectable		 6ew0F-4cp6A:
11.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fdw LEUCINE RICH
HYPOTHETICAL PROTEIN

(Bacteroides
ovatus) 		PF07523
(Big_3)
PF13306
(LRR_5) 		5 ASP A 157
LEU A 195
SER A 162
LEU A 169
LEU A 135
 None
 1.22A 6ew0F-4fdwA:
undetectable		 6ew0F-4fdwA:
10.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hes BETA-LACTAMASE CLASS
A-LIKE PROTEIN

(Veillonella
parvula) 		PF13354
(Beta-lactamase2) 		5 VAL A 224
ASP A 222
ALA A  55
SER A  53
GLN A  96
 None
 1.19A 6ew0F-4hesA:
undetectable		 6ew0F-4hesA:
13.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iv6 ACYL-COA
DEHYDROGENASE FADE3

(Mycolicibacterium
smegmatis) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		5 VAL A 348
ASP A 347
HIS A 337
ALA A 333
LEU A 284
 None
 1.17A 6ew0F-4iv6A:
undetectable		 6ew0F-4iv6A:
11.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jja HYPOTHETICAL PROTEIN

(Bacteroides
fragilis) 		PF07075
(DUF1343) 		5 ASP A 129
ALA A 198
LEU A 207
ARG A 143
LEU A 184
 None
None
None
None
GOL  A 403 ( 4.9A)
 1.14A 6ew0F-4jjaA:
3.2		 6ew0F-4jjaA:
13.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kfv GOLGI
REASSEMBLY-STACKING
PROTEIN 1

(Rattus
norvegicus) 		PF04495
(GRASP55_65) 		5 VAL A 117
ASP A 116
ALA A 123
SER A 121
LEU A 162
 None
 1.20A 6ew0F-4kfvA:
undetectable		 6ew0F-4kfvA:
15.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kt1 LEUCINE-RICH
REPEAT-CONTAINING
G-PROTEIN COUPLED
RECEPTOR 4

(Homo sapiens) 		PF01462
(LRRNT)
PF13516
(LRR_6)
PF13855
(LRR_8) 		5 LEU A  93
ALA A 124
LEU A 117
GLN A 113
LEU A 134
 None
 1.13A 6ew0F-4kt1A:
undetectable		 6ew0F-4kt1A:
10.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l68 LEUCINE-RICH REPEAT
PROTEIN KINASE-LIKE
PROTEIN

(Arabidopsis
thaliana) 		PF07714
(Pkinase_Tyr) 		5 VAL A 551
LEU A 387
ALA A 502
LEU A 391
LEU A 517
 None
 1.19A 6ew0F-4l68A:
undetectable		 6ew0F-4l68A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nim VERSICOLORIN
REDUCTASE

(Brucella
melitensis) 		PF13561
(adh_short_C2) 		5 ASP A  65
ALA A  93
LEU A 123
ARG A 118
LEU A 165
 None
 1.11A 6ew0F-4nimA:
6.4		 6ew0F-4nimA:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nru RNA DEPENDENT RNA
POLYMERASE

(Norwalk virus) 		PF00680
(RdRP_1) 		5 VAL A 324
ASP A 354
ALA A 320
LEU A 367
LEU A 379
 None
 1.08A 6ew0F-4nruA:
undetectable		 6ew0F-4nruA:
9.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p22 UBIQUITIN-LIKE
MODIFIER-ACTIVATING
ENZYME 1

(Homo sapiens) 		PF00899
(ThiF)
PF16190
(E1_FCCH)
PF16191
(E1_4HB) 		5 ASP A 111
LEU A 151
ALA A 128
SER A 131
LEU A  76
 None
 1.00A 6ew0F-4p22A:
undetectable		 6ew0F-4p22A:
10.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pu5 TOXIN-ANTITOXIN
SYSTEM TOXIN HIPA
FAMILY

(Shewanella
oneidensis) 		PF07804
(HipA_C)
PF13657
(Couple_hipA) 		5 VAL A 431
ASP A 430
GLU A 427
LEU A 293
LEU A 297
 None
 1.13A 6ew0F-4pu5A:
undetectable		 6ew0F-4pu5A:
11.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qmk TYPE III SECRETION
SYSTEM EFFECTOR
PROTEIN EXOU

(Pseudomonas
fluorescens) 		PF01734
(Patatin) 		5 VAL A  45
LEU A 458
ALA A 432
LEU A 441
LEU A  35
 None
 1.14A 6ew0F-4qmkA:
undetectable		 6ew0F-4qmkA:
9.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qtq XAC2610 PROTEIN

(Xanthomonas
citri) 		no annotation 5 ASP A 137
LEU A 179
ASP A 155
LEU A 193
LEU A 203
 None
None
CA  A 301 (-2.9A)
None
None
 1.17A 6ew0F-4qtqA:
undetectable		 6ew0F-4qtqA:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qxe LEUCINE-RICH
REPEAT-CONTAINING
G-PROTEIN COUPLED
RECEPTOR 4, LINKER,
VARIABLE LYMPHOCYTE
RECEPTOR B

(Eptatretus
burgeri;
Homo sapiens) 		PF01462
(LRRNT)
PF11921
(DUF3439)
PF13516
(LRR_6)
PF13855
(LRR_8) 		5 LEU A  93
ALA A 124
LEU A 117
GLN A 113
LEU A 134
 None
 1.03A 6ew0F-4qxeA:
undetectable		 6ew0F-4qxeA:
10.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qxf LEUCINE-RICH
REPEAT-CONTAINING
G-PROTEIN COUPLED
RECEPTOR 4, VARIABLE
LYMPHOCYTE RECEPTOR
B

(Eptatretus
burgeri;
Homo sapiens) 		PF01462
(LRRNT)
PF11921
(DUF3439)
PF13855
(LRR_8) 		5 LEU A  93
ALA A 124
LEU A 117
GLN A 113
LEU A 134
 None
 1.20A 6ew0F-4qxfA:
undetectable		 6ew0F-4qxfA:
14.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rq9 PHOTORECEPTOR-HISTID
INE KINASE BPHP

(Stigmatella
aurantiaca) 		PF01590
(GAF)
PF08446
(PAS_2) 		5 ASP A 105
LEU A  84
SER A 126
LEU A 121
LEU A  56
 None
None
GOL  A 415 ( 4.3A)
None
None
 1.18A 6ew0F-4rq9A:
undetectable		 6ew0F-4rq9A:
14.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4toi 30S RIBOSOMAL
PROTEIN S2,RIBOSOMAL
PROTEIN S1

(Escherichia
coli) 		PF00318
(Ribosomal_S2)
PF00575
(S1) 		5 VAL A 196
ASP A 197
LEU A 214
GLN A  89
LEU A  57
 None
 1.06A 6ew0F-4toiA:
undetectable		 6ew0F-4toiA:
14.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uip REPEBODY (RAC1)

(Eptatretus
burgeri;
Listeria
monocytogenes;
synthetic
construct) 		PF11921
(DUF3439)
PF12354
(Internalin_N)
PF13855
(LRR_8) 		5 ASP B  78
LEU B 133
ASP B 107
LEU B 112
LEU B  93
 None
 1.06A 6ew0F-4uipB:
undetectable		 6ew0F-4uipB:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wfc EXOSOME COMPLEX
PROTEIN LRP1

(Saccharomyces
cerevisiae) 		PF04000
(Sas10_Utp3) 		5 LEU B  37
ALA B  54
SER B  58
LEU B  33
LEU B  28
 None
 1.18A 6ew0F-4wfcB:
undetectable		 6ew0F-4wfcB:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yzg PROTEIN PHOSPHATASE
2C 57

(Arabidopsis
thaliana) 		PF00481
(PP2C) 		5 VAL A  91
ASP A  75
ALA A 294
SER A 181
LEU A 328
 None
 1.14A 6ew0F-4yzgA:
undetectable		 6ew0F-4yzgA:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ao0 DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1

(Homo sapiens) 		PF01966
(HD) 		5 VAL A 310
ASP A 311
LEU A 128
ALA A 175
LEU A 132
 None
FE  A1001 ( 2.6A)
None
None
None
 1.23A 6ew0F-5ao0A:
undetectable		 6ew0F-5ao0A:
9.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b4p REPEBODY

(synthetic
construct) 		PF11921
(DUF3439)
PF12354
(Internalin_N)
PF13855
(LRR_8) 		5 ASP A  77
LEU A 131
ASP A 105
LEU A 110
LEU A  92
 SO4  A 302 (-4.4A)
None
None
None
None
 1.18A 6ew0F-5b4pA:
undetectable		 6ew0F-5b4pA:
15.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d01 N-ACETYL-ALPHA-D-GLU
COSAMINYL L-MALATE
SYNTHASE

(Bacillus
subtilis) 		PF00534
(Glycos_transf_1)
PF13439
(Glyco_transf_4) 		5 ASP A 161
GLU A 158
ASP A 136
LEU A  97
LEU A 120
 None
 1.24A 6ew0F-5d01A:
undetectable		 6ew0F-5d01A:
13.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dih MICROCOMPARTMENTS
PROTEIN

(Haliangium
ochraceum) 		PF00936
(BMC) 		5 GLU A  26
LEU A 140
ALA A 132
LEU A 147
LEU A 105
 None
 1.19A 6ew0F-5dihA:
undetectable		 6ew0F-5dihA:
14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dn6 ATP SYNTHASE SUBUNIT
ALPHA

(Paracoccus
denitrificans) 		PF00006
(ATP-synt_ab)
PF00306
(ATP-synt_ab_C)
PF02874
(ATP-synt_ab_N) 		5 LEU A 272
ASP A 270
ALA A 251
LEU A 306
LEU A 322
 None
MG  A 601 ( 3.9A)
None
None
None
 1.14A 6ew0F-5dn6A:
2.5		 6ew0F-5dn6A:
11.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f7v LMO0181 PROTEIN

(Listeria
monocytogenes) 		PF01547
(SBP_bac_1) 		5 VAL A 149
ASP A 358
SER A 366
LEU A 352
LEU A 339
 None
 1.23A 6ew0F-5f7vA:
undetectable		 6ew0F-5f7vA:
11.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fcl CRISPR-ASSOCIATED
ENDONUCLEASE CAS1

(Pectobacterium
atrosepticum) 		PF01867
(Cas_Cas1) 		5 LEU A 247
ASP A 119
ALA A 133
LEU A 263
LEU A 270
 None
 1.08A 6ew0F-5fclA:
undetectable		 6ew0F-5fclA:
12.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5giu PROLINE DIPEPTIDASE

(Deinococcus
radiodurans) 		PF00557
(Peptidase_M24)
PF01321
(Creatinase_N) 		5 ASP A 240
ASP A 329
ALA A 248
LEU A 283
LEU A 270
 None
 1.21A 6ew0F-5giuA:
undetectable		 6ew0F-5giuA:
11.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gs2 REPEBODY

(Escherichia
coli) 		PF11921
(DUF3439)
PF12354
(Internalin_N)
PF13855
(LRR_8) 		5 ASP B  77
LEU B 132
ASP B 106
LEU B 111
LEU B  92
 None
 1.14A 6ew0F-5gs2B:
undetectable		 6ew0F-5gs2B:
13.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iv8 LPS BIOSYNTHESIS
PROTEIN

(Klebsiella
pneumoniae) 		PF04453
(OstA_C) 		5 ASP A 629
GLU A 658
LEU A 536
ALA A 632
SER A 656
 None
 1.02A 6ew0F-5iv8A:
undetectable		 6ew0F-5iv8A:
9.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ivl DEAD-BOX
ATP-DEPENDENT RNA
HELICASE CSHA

(Geobacillus
stearothermophilus) 		no annotation 5 VAL B  42
ASP B  41
GLU B 201
LEU B   9
LEU B   7
 None
 1.04A 6ew0F-5ivlB:
undetectable		 6ew0F-5ivlB:
10.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jzb 4,5:9,10-DISECO-3-HY
DROXY-5,9,17-TRIOXOA
NDROSTA-1(10),2-DIEN
E-4-OATE HYDROLASE

(Mycobacterium
tuberculosis) 		PF12697
(Abhydrolase_6) 		5 LEU A 105
ASP A 101
SER A  79
LEU A  69
LEU A  42
 None
 1.19A 6ew0F-5jzbA:
2.9		 6ew0F-5jzbA:
15.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lb8 ATP-DEPENDENT DNA
HELICASE Q5

(Homo sapiens) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF16124
(RecQ_Zn_bind) 		5 ASP A  85
ASP A 353
ALA A  56
SER A  59
LEU A  93
 None
 1.08A 6ew0F-5lb8A:
undetectable		 6ew0F-5lb8A:
9.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lpy PROTEIN
BRASSINOSTEROID
INSENSITIVE 1

(Arabidopsis
thaliana) 		PF00069
(Pkinase) 		5 LEU A1127
ALA A 987
SER A 990
LEU A1080
LEU A 968
 None
 0.97A 6ew0F-5lpyA:
undetectable		 6ew0F-5lpyA:
12.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lpz PROTEIN
BRASSINOSTEROID
INSENSITIVE 1

(Arabidopsis
thaliana) 		PF00069
(Pkinase) 		5 LEU A1127
ALA A 987
SER A 990
LEU A1080
LEU A 968
 None
 1.06A 6ew0F-5lpzA:
undetectable		 6ew0F-5lpzA:
12.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lst ATP-DEPENDENT DNA
HELICASE Q4

(Homo sapiens) 		PF00270
(DEAD)
PF00271
(Helicase_C) 		5 VAL A 783
ASP A 782
LEU A 720
ALA A 785
LEU A 692
 None
 1.10A 6ew0F-5lstA:
undetectable		 6ew0F-5lstA:
7.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5mjs TUBULIN BETA CHAIN

(Schizosaccharomyces
pombe) 		no annotation 6 ASP A  26
LEU A 215
ASP A 224
HIS A 227
ALA A 231
LEU A 360
 None
 1.01A 6ew0F-5mjsA:
59.4		 6ew0F-5mjsA:
75.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5mjs TUBULIN BETA CHAIN

(Schizosaccharomyces
pombe) 		no annotation 5 ASP A  26
LEU A 215
ASP A 224
LEU A 272
LEU A 360
 None
 0.85A 6ew0F-5mjsA:
59.4		 6ew0F-5mjsA:
75.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5mjs TUBULIN BETA CHAIN

(Schizosaccharomyces
pombe) 		no annotation 6 GLU A  27
LEU A 215
ASP A 224
HIS A 227
ALA A 231
LEU A 360
 None
 1.03A 6ew0F-5mjsA:
59.4		 6ew0F-5mjsA:
75.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5mjs TUBULIN BETA CHAIN

(Schizosaccharomyces
pombe) 		no annotation 5 GLU A  27
LEU A 215
ASP A 224
LEU A 272
LEU A 360
 None
 0.90A 6ew0F-5mjsA:
59.4		 6ew0F-5mjsA:
75.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mog PHYTOENE
DEHYDROGENASE,
CHLOROPLASTIC/CHROMO
PLASTIC

(Oryza sativa) 		PF01593
(Amino_oxidase) 		5 VAL A 138
GLU A 134
LEU A 313
ARG A 180
LEU A 117
 EPE  A 602 (-4.0A)
FAD  A 600 (-2.7A)
None
None
None
 1.23A 6ew0F-5mogA:
undetectable		 6ew0F-5mogA:
10.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5n5n TUBULIN BETA CHAIN

(Homo sapiens) 		no annotation 10 VAL B  23
ASP B  26
GLU B  27
LEU B 217
ASP B 226
HIS B 229
ALA B 233
LEU B 275
GLN B 281
LEU B 371
 None
 0.86A 6ew0F-5n5nB:
62.1		 6ew0F-5n5nB:
93.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5n5n TUBULIN BETA CHAIN

(Homo sapiens) 		no annotation 10 VAL B  23
ASP B  26
GLU B  27
LEU B 217
ASP B 226
HIS B 229
ALA B 233
SER B 236
GLN B 281
LEU B 371
 None
 0.88A 6ew0F-5n5nB:
62.1		 6ew0F-5n5nB:
93.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nh1 GASDERMIN-D

(Homo sapiens) 		PF04598
(Gasdermin) 		5 GLU A 394
LEU A 469
ALA A 392
SER A 395
LEU A 441
 None
 1.13A 6ew0F-5nh1A:
undetectable		 6ew0F-5nh1A:
15.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t81 EPOB

(Sorangium
cellulosum) 		PF00668
(Condensation) 		5 VAL A 205
ASP A 206
LEU A 218
ASP A 216
LEU A 430
 None
 0.81A 6ew0F-5t81A:
undetectable		 6ew0F-5t81A:
8.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uid AMINOTRANSFERASE
TLMJ

(Streptoalloteichus
hindustanus) 		PF01041
(DegT_DnrJ_EryC1) 		5 ALA A 159
SER A 296
ARG A 197
GLN A  51
LEU A  45
 None
 1.09A 6ew0F-5uidA:
undetectable		 6ew0F-5uidA:
12.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w3j TUBULIN BETA CHAIN

(Saccharomyces
cerevisiae) 		PF00091
(Tubulin)
PF03953
(Tubulin_C) 		5 VAL B  23
ASP B  26
GLU B  27
GLN B 279
LEU B 361
 TA1  B 502 (-3.9A)
TA1  B 502 (-4.1A)
TA1  B 502 (-3.6A)
TA1  B 502 ( 4.3A)
TA1  B 502 (-3.7A)
 1.09A 6ew0F-5w3jB:
60.5		 6ew0F-5w3jB:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w3j TUBULIN BETA CHAIN

(Saccharomyces
cerevisiae) 		PF00091
(Tubulin)
PF03953
(Tubulin_C) 		7 VAL B  23
ASP B  26
GLU B  27
LEU B 215
ASP B 224
SER B 234
LEU B 361
 TA1  B 502 (-3.9A)
TA1  B 502 (-4.1A)
TA1  B 502 (-3.6A)
None
None
TA1  B 502 ( 4.9A)
TA1  B 502 (-3.7A)
 0.80A 6ew0F-5w3jB:
60.5		 6ew0F-5w3jB:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w3j TUBULIN BETA CHAIN

(Saccharomyces
cerevisiae) 		PF00091
(Tubulin)
PF03953
(Tubulin_C) 		5 VAL B  23
ASP B  26
GLU B  27
LEU B 273
SER B 234
 TA1  B 502 (-3.9A)
TA1  B 502 (-4.1A)
TA1  B 502 (-3.6A)
None
TA1  B 502 ( 4.9A)
 1.24A 6ew0F-5w3jB:
60.5		 6ew0F-5w3jB:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w4b ADENOSYLHOMOCYSTEINA
SE

(Homo sapiens) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		5 GLU A 105
LEU A 344
SER A  78
LEU A 347
GLN A 324
 None
NAD  A 501 (-4.0A)
None
9W4  A 502 (-4.1A)
9W4  A 502 (-4.2A)
 1.15A 6ew0F-5w4bA:
6.1		 6ew0F-5w4bA:
10.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x8g 2-SUCCINYLBENZOATE--
COA LIGASE

(Bacillus
subtilis) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		5 VAL A 124
ASP A 123
ALA A  69
LEU A  82
ARG A  92
 None
 1.23A 6ew0F-5x8gA:
undetectable		 6ew0F-5x8gA:
10.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y59 ATP-DEPENDENT DNA
HELICASE II SUBUNIT
2

(Saccharomyces
cerevisiae) 		no annotation 5 VAL B 113
ASP B 116
LEU B  87
LEU B  29
ARG B  86
 None
 1.11A 6ew0F-5y59B:
2.7		 6ew0F-5y59B:
16.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y6q ALDEHYDE OXIDASE
MEDIUM SUBUNIT

(Methylobacillus
sp. KY4400) 		no annotation 5 LEU B  59
ALA B  87
SER B 228
LEU B  77
LEU B 170
 None
 0.84A 6ew0F-5y6qB:
undetectable		 6ew0F-5y6qB:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yl7 PSEUDOALTEROMONAS
ARCTICA PAMC 21717

(Pseudoalteromonas
arctica) 		no annotation 5 VAL A 181
ASP A 310
LEU A 167
LEU A 165
LEU A 454
 None
 1.00A 6ew0F-5yl7A:
undetectable		 6ew0F-5yl7A:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6byi BETA-MANNOSIDASE

(Xanthomonas
citri) 		no annotation 5 VAL A 460
ASP A 523
ASP A 434
ALA A 456
LEU A 510
 None
 1.11A 6ew0F-6byiA:
undetectable		 6ew0F-6byiA:
undetectable