SIMILAR PATTERNS OF AMINO ACIDS FOR 6EW0_F_TA1F502

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bg5 FUSION PROTEIN OF
ALPHA-NA,K-ATPASE
WITH GLUTATHIONE
S-TRANSFERASE

(Rattus
norvegicus) 		PF02798
(GST_N)
PF14497
(GST_C_3) 		5 LEU A 137
ASP A 152
ALA A 158
LEU A 176
ARG A 136
 None
 1.15A 6ew0F-1bg5A:
undetectable		 6ew0F-1bg5A:
14.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1biy LACTOFERRIN

(Bubalus bubalis) 		PF00405
(Transferrin) 		5 GLU A 211
LEU A 106
ALA A  94
LEU A 232
ARG A 236
 None
 1.22A 6ew0F-1biyA:
undetectable		 6ew0F-1biyA:
7.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1epz DTDP-6-DEOXY-D-XYLO-
4-HEXULOSE
3,5-EPIMERASE

(Methanothermobacter
thermautotrophicus) 		PF00908
(dTDP_sugar_isom) 		5 VAL A  85
ASP A  84
ASP A 172
LEU A 166
LEU A 125
 None
None
TYD  A2187 ( 4.4A)
None
None
 1.20A 6ew0F-1epzA:
undetectable		 6ew0F-1epzA:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gff BACTERIOPHAGE G4
CAPSID PROTEINS GPF,
GPG, GPJ

(Escherichia
virus G4) 		PF02305
(Phage_F) 		5 ASP 1 391
GLU 1 392
ASP 1 381
ALA 1 373
SER 1 372
 None
 1.19A 6ew0F-1gff1:
undetectable		 6ew0F-1gff1:
10.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h2b ALCOHOL
DEHYDROGENASE

(Aeropyrum
pernix) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 VAL A  33
ASP A  32
GLU A  31
ARG A  47
LEU A 336
 None
 1.19A 6ew0F-1h2bA:
2.2		 6ew0F-1h2bA:
12.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h8l CARBOXYPEPTIDASE
GP180 RESIDUES
503-882

(Lophonetta
specularioides) 		PF00246
(Peptidase_M14)
PF13620
(CarboxypepD_reg) 		5 VAL A 368
ASP A 369
LEU A 176
LEU A 213
GLN A 297
 None
 1.12A 6ew0F-1h8lA:
undetectable		 6ew0F-1h8lA:
11.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hkk CHITOTRIOSIDASE-1

(Homo sapiens) 		PF00704
(Glyco_hydro_18) 		5 VAL A 243
ASP A 244
LEU A 385
SER A 226
LEU A 381
 None
 1.18A 6ew0F-1hkkA:
undetectable		 6ew0F-1hkkA:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hkw DIAMINOPIMELATE
DECARBOXYLASE

(Mycobacterium
tuberculosis) 		PF00278
(Orn_DAP_Arg_deC)
PF02784
(Orn_Arg_deC_N) 		5 VAL A 166
LEU A 275
ASP A 220
ALA A 227
LEU A 279
 None
 1.09A 6ew0F-1hkwA:
undetectable		 6ew0F-1hkwA:
10.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t6p PHENYLALANINE
AMMONIA-LYASE

(Rhodotorula
toruloides) 		PF00221
(Lyase_aromatic) 		5 LEU A 532
ALA A 701
SER A 704
LEU A 528
LEU A 711
 None
 1.13A 6ew0F-1t6pA:
undetectable		 6ew0F-1t6pA:
7.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t92 GENERAL SECRETION
PATHWAY PROTEIN G

(Klebsiella
pneumoniae) 		PF08334
(T2SSG) 		5 ASP A 125
LEU A  67
SER A 122
LEU A  64
GLN A  62
 None
 1.22A 6ew0F-1t92A:
undetectable		 6ew0F-1t92A:
24.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u0u DIHYDROPINOSYLVIN
SYNTHASE

(Pinus
sylvestris) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		5 VAL A 105
LEU A 153
ALA A 109
LEU A 190
ARG A 159
 None
 1.21A 6ew0F-1u0uA:
undetectable		 6ew0F-1u0uA:
12.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v6c ALKALINE SERINE
PROTEASE

(Pseudoalteromonas
sp. AS-11) 		PF00082
(Peptidase_S8)
PF02225
(PA) 		5 GLU A   2
ASP A  34
HIS A  37
ALA A  75
LEU A 206
 CA  A 503 (-3.4A)
None
None
None
None
 1.24A 6ew0F-1v6cA:
undetectable		 6ew0F-1v6cA:
9.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vf8 SECRETORY PROTEIN

(Mus musculus) 		PF00704
(Glyco_hydro_18) 		5 VAL A 222
ASP A 223
LEU A 366
SER A 205
LEU A 362
 None
 1.18A 6ew0F-1vf8A:
undetectable		 6ew0F-1vf8A:
12.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wb0 CHITOTRIOSIDASE 1

(Homo sapiens) 		PF00704
(Glyco_hydro_18) 		5 VAL A 243
ASP A 244
LEU A 387
SER A 226
LEU A 383
 None
 1.16A 6ew0F-1wb0A:
undetectable		 6ew0F-1wb0A:
11.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y4u CHAPERONE PROTEIN
HTPG

(Escherichia
coli) 		PF00183
(HSP90)
PF02518
(HATPase_c) 		5 GLU A 273
LEU A 278
SER A 328
LEU A 352
GLN A 358
 None
 1.21A 6ew0F-1y4uA:
undetectable		 6ew0F-1y4uA:
10.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a3l AMP DEAMINASE

(Arabidopsis
thaliana) 		PF00962
(A_deaminase) 		5 GLU A 603
ASP A 389
HIS A 391
ALA A 680
LEU A 544
 None
None
ZN  A 840 ( 3.2A)
None
None
 0.98A 6ew0F-2a3lA:
undetectable		 6ew0F-2a3lA:
7.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a7m N-ACYL HOMOSERINE
LACTONE HYDROLASE

(Bacillus
thuringiensis) 		PF00753
(Lactamase_B) 		5 GLU A 127
LEU A 187
SER A 170
LEU A 220
GLN A 162
 None
 1.15A 6ew0F-2a7mA:
undetectable		 6ew0F-2a7mA:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cuk GLYCERATE
DEHYDROGENASE/GLYOXY
LATE REDUCTASE

(Thermus
thermophilus) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		5 ASP A  53
LEU A  22
ALA A  70
LEU A 301
LEU A  66
 None
 1.13A 6ew0F-2cukA:
2.1		 6ew0F-2cukA:
15.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e5a LIPOYLTRANSFERASE 1

(Bos taurus) 		no annotation 5 VAL A 114
LEU A  39
ALA A 110
LEU A  89
ARG A  41
 None
 1.10A 6ew0F-2e5aA:
undetectable		 6ew0F-2e5aA:
15.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g2o MALONYL COA-ACYL
CARRIER PROTEIN
TRANSACYLASE

(Escherichia
coli) 		PF00698
(Acyl_transf_1) 		5 VAL A 100
LEU A  44
ALA A 110
GLN A  14
LEU A  93
 None
None
None
None
SO4  A1001 (-4.3A)
 1.12A 6ew0F-2g2oA:
undetectable		 6ew0F-2g2oA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nbr GAMMA-CRYSTALLIN C

(Homo sapiens) 		PF00030
(Crystall) 		5 ASP A 113
ALA A 163
LEU A 145
ARG A 167
LEU A 104
 None
 1.17A 6ew0F-2nbrA:
undetectable		 6ew0F-2nbrA:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qfc PLCR PROTEIN

(Bacillus
thuringiensis) 		PF01381
(HTH_3) 		5 VAL A 196
ASP A 195
ALA A 233
SER A 231
GLN A 118
 None
 1.23A 6ew0F-2qfcA:
undetectable		 6ew0F-2qfcA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qna IMPORTIN SUBUNIT
BETA-1

(Homo sapiens) 		PF13513
(HEAT_EZ) 		5 VAL A 638
GLU A 637
ASP A 605
LEU A 611
LEU A 673
 None
 1.14A 6ew0F-2qnaA:
undetectable		 6ew0F-2qnaA:
7.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vl7 XPD

(Sulfurisphaera
tokodaii) 		PF06733
(DEAD_2)
PF13307
(Helicase_C_2) 		5 ASP A 307
LEU A 324
ALA A 190
LEU A 333
LEU A 481
 None
 1.23A 6ew0F-2vl7A:
undetectable		 6ew0F-2vl7A:
10.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ybu ACIDIC MAMMALIAN
CHITINASE

(Homo sapiens) 		PF00704
(Glyco_hydro_18) 		5 VAL A 243
ASP A 244
LEU A 387
SER A 226
LEU A 383
 None
 1.16A 6ew0F-2ybuA:
undetectable		 6ew0F-2ybuA:
11.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zgd 3 REPEAT SYNTHETIC
ANKYRIN

(-) 		PF12796
(Ank_2) 		5 VAL A  40
ASP A  38
GLU A  39
LEU A 105
ALA A  32
 None
CD  A 413 ( 2.4A)
CD  A 410 ( 2.1A)
None
None
 1.09A 6ew0F-2zgdA:
undetectable		 6ew0F-2zgdA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bg2 DGTP
TRIPHOSPHOHYDROLASE

(Leeuwenhoekiella
blandensis) 		PF01966
(HD) 		5 VAL A 249
ASP A 117
HIS A 116
ALA A 112
LEU A 168
 None
 1.18A 6ew0F-3bg2A:
undetectable		 6ew0F-3bg2A:
10.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3blx ISOCITRATE
DEHYDROGENASE [NAD]
SUBUNIT 2

(Saccharomyces
cerevisiae) 		PF00180
(Iso_dh) 		5 GLU B  54
LEU B  99
ALA B  73
SER B  76
LEU B 103
 None
 1.12A 6ew0F-3blxB:
undetectable		 6ew0F-3blxB:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d3l ARACHIDONATE
12-LIPOXYGENASE,
12S-TYPE

(Homo sapiens) 		PF00305
(Lipoxygenase) 		5 LEU A 183
SER A 440
ARG A 430
GLN A 427
LEU A 280
 None
 1.23A 6ew0F-3d3lA:
undetectable		 6ew0F-3d3lA:
8.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3goz LEUCINE-RICH
REPEAT-CONTAINING
PROTEIN

(Legionella
pneumophila) 		no annotation 5 ASP A  98
GLU A  99
LEU A 114
SER A  68
LEU A  87
 None
 1.22A 6ew0F-3gozA:
undetectable		 6ew0F-3gozA:
14.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3grn MUTT RELATED PROTEIN

(Methanosarcina
mazei) 		PF00293
(NUDIX) 		5 VAL A  89
LEU A 117
LEU A 113
ARG A 127
LEU A  24
 None
 1.24A 6ew0F-3grnA:
undetectable		 6ew0F-3grnA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hjv MALONYL COA-ACYL
CARRIER PROTEIN
TRANSACYLASE

(Vibrio cholerae) 		PF00698
(Acyl_transf_1) 		5 VAL A 105
LEU A  49
ALA A 115
GLN A  19
LEU A  98
 None
None
None
CL  A 328 (-3.5A)
None
 1.13A 6ew0F-3hjvA:
undetectable		 6ew0F-3hjvA:
13.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hl1 FERRITIN LIKE
PROTEIN

(Caulobacter
vibrioides) 		PF12902
(Ferritin-like) 		5 VAL A 183
LEU A  10
ALA A 194
LEU A 150
GLN A  15
 None
 1.17A 6ew0F-3hl1A:
undetectable		 6ew0F-3hl1A:
14.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3im8 MALONYL ACYL CARRIER
PROTEIN TRANSACYLASE

(Streptococcus
pneumoniae) 		PF00698
(Acyl_transf_1) 		5 VAL A  98
LEU A  44
ALA A 108
GLN A  14
LEU A  91
 None
 1.08A 6ew0F-3im8A:
undetectable		 6ew0F-3im8A:
14.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ku0 RIBOSOME-INACTIVATIN
G PROTEIN GELONIN

(Suregada
multiflora) 		PF00161
(RIP) 		5 VAL A  54
LEU A  40
ASP A  69
LEU A 242
ARG A  41
 None
 1.07A 6ew0F-3ku0A:
undetectable		 6ew0F-3ku0A:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lmd GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE

(Corynebacterium
glutamicum) 		PF00348
(polyprenyl_synt) 		5 VAL A 277
GLU A 273
LEU A 289
SER A 305
LEU A 258
 None
 1.07A 6ew0F-3lmdA:
undetectable		 6ew0F-3lmdA:
10.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oak TRANSCRIPTION FACTOR
IWS1

(Saccharomyces
cerevisiae) 		PF08711
(Med26) 		6 ASP A 163
GLU A 164
LEU A 225
LEU A 242
ARG A 222
LEU A 217
 None
 1.30A 6ew0F-3oakA:
undetectable		 6ew0F-3oakA:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oee ATP SYNTHASE SUBUNIT
ALPHA

(Saccharomyces
cerevisiae) 		PF00006
(ATP-synt_ab)
PF00306
(ATP-synt_ab_C)
PF02874
(ATP-synt_ab_N) 		5 LEU A 273
ASP A 271
ALA A 252
LEU A 307
LEU A 323
 None
MG  A 700 ( 3.6A)
None
None
None
 1.18A 6ew0F-3oeeA:
undetectable		 6ew0F-3oeeA:
11.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pfe SUCCINYL-DIAMINOPIME
LATE DESUCCINYLASE

(Legionella
pneumophila) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		5 ASP A 190
ASP A 168
LEU A 176
GLN A 423
LEU A  92
 ZN  A 501 ( 1.9A)
None
None
GOL  A 519 (-4.7A)
None
 1.24A 6ew0F-3pfeA:
undetectable		 6ew0F-3pfeA:
11.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v65 LOW-DENSITY
LIPOPROTEIN
RECEPTOR-RELATED
PROTEIN 4

(Rattus
norvegicus) 		PF00058
(Ldl_recept_b)
PF14670
(FXa_inhibition) 		5 LEU B 443
ASP B 474
ALA B 495
LEU B 463
LEU B 467
 None
 1.14A 6ew0F-3v65B:
undetectable		 6ew0F-3v65B:
11.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wrc GALLATE DIOXYGENASE

(Sphingomonas
paucimobilis) 		PF02900
(LigB)
PF07746
(LigA) 		5 ASP A 276
LEU A 134
ALA A 185
LEU A 133
LEU A 273
 None
 1.23A 6ew0F-3wrcA:
undetectable		 6ew0F-3wrcA:
10.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a11 DNA EXCISION REPAIR
PROTEIN ERCC-8

(Homo sapiens) 		PF00400
(WD40) 		5 LEU B 226
ALA B 191
SER B 146
LEU B 260
ARG B 270
 None
 1.21A 6ew0F-4a11B:
undetectable		 6ew0F-4a11B:
10.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ags THIOL-DEPENDENT
REDUCTASE 1

(Leishmania
infantum) 		PF13417
(GST_N_3)
PF16865
(GST_C_5) 		5 VAL A 327
LEU A 252
ASP A 302
ALA A 385
LEU A 416
 None
 1.17A 6ew0F-4agsA:
undetectable		 6ew0F-4agsA:
11.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4blp PACKAGING ENZYME P4

(Pseudomonas
phage phi13) 		PF11602
(NTPase_P4) 		5 VAL A 210
ASP A 169
ALA A 200
LEU A  82
LEU A  89
 None
 1.21A 6ew0F-4blpA:
undetectable		 6ew0F-4blpA:
13.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cp6 CHOLINE BINDING
PROTEIN PCPA

(Streptococcus
pneumoniae) 		PF13306
(LRR_5) 		5 GLU A 157
LEU A 217
ALA A 182
LEU A 192
LEU A 175
 None
 1.25A 6ew0F-4cp6A:
undetectable		 6ew0F-4cp6A:
11.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fdw LEUCINE RICH
HYPOTHETICAL PROTEIN

(Bacteroides
ovatus) 		PF07523
(Big_3)
PF13306
(LRR_5) 		5 ASP A 157
LEU A 195
SER A 162
LEU A 169
LEU A 135
 None
 1.22A 6ew0F-4fdwA:
undetectable		 6ew0F-4fdwA:
10.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hes BETA-LACTAMASE CLASS
A-LIKE PROTEIN

(Veillonella
parvula) 		PF13354
(Beta-lactamase2) 		5 VAL A 224
ASP A 222
ALA A  55
SER A  53
GLN A  96
 None
 1.19A 6ew0F-4hesA:
undetectable		 6ew0F-4hesA:
13.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iv6 ACYL-COA
DEHYDROGENASE FADE3

(Mycolicibacterium
smegmatis) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		5 VAL A 348
ASP A 347
HIS A 337
ALA A 333
LEU A 284
 None
 1.17A 6ew0F-4iv6A:
undetectable		 6ew0F-4iv6A:
11.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jja HYPOTHETICAL PROTEIN

(Bacteroides
fragilis) 		PF07075
(DUF1343) 		5 ASP A 129
ALA A 198
LEU A 207
ARG A 143
LEU A 184
 None
None
None
None
GOL  A 403 ( 4.9A)
 1.14A 6ew0F-4jjaA:
3.2		 6ew0F-4jjaA:
13.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kfv GOLGI
REASSEMBLY-STACKING
PROTEIN 1

(Rattus
norvegicus) 		PF04495
(GRASP55_65) 		5 VAL A 117
ASP A 116
ALA A 123
SER A 121
LEU A 162
 None
 1.20A 6ew0F-4kfvA:
undetectable		 6ew0F-4kfvA:
15.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kt1 LEUCINE-RICH
REPEAT-CONTAINING
G-PROTEIN COUPLED
RECEPTOR 4

(Homo sapiens) 		PF01462
(LRRNT)
PF13516
(LRR_6)
PF13855
(LRR_8) 		5 LEU A  93
ALA A 124
LEU A 117
GLN A 113
LEU A 134
 None
 1.13A 6ew0F-4kt1A:
undetectable		 6ew0F-4kt1A:
10.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l68 LEUCINE-RICH REPEAT
PROTEIN KINASE-LIKE
PROTEIN

(Arabidopsis
thaliana) 		PF07714
(Pkinase_Tyr) 		5 VAL A 551
LEU A 387
ALA A 502
LEU A 391
LEU A 517
 None
 1.19A 6ew0F-4l68A:
undetectable		 6ew0F-4l68A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nim VERSICOLORIN
REDUCTASE

(Brucella
melitensis) 		PF13561
(adh_short_C2) 		5 ASP A  65
ALA A  93
LEU A 123
ARG A 118
LEU A 165
 None
 1.11A 6ew0F-4nimA:
6.4		 6ew0F-4nimA:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nru RNA DEPENDENT RNA
POLYMERASE

(Norwalk virus) 		PF00680
(RdRP_1) 		5 VAL A 324
ASP A 354
ALA A 320
LEU A 367
LEU A 379
 None
 1.08A 6ew0F-4nruA:
undetectable		 6ew0F-4nruA:
9.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p22 UBIQUITIN-LIKE
MODIFIER-ACTIVATING
ENZYME 1

(Homo sapiens) 		PF00899
(ThiF)
PF16190
(E1_FCCH)
PF16191
(E1_4HB) 		5 ASP A 111
LEU A 151
ALA A 128
SER A 131
LEU A  76
 None
 1.00A 6ew0F-4p22A:
undetectable		 6ew0F-4p22A:
10.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pu5 TOXIN-ANTITOXIN
SYSTEM TOXIN HIPA
FAMILY

(Shewanella
oneidensis) 		PF07804
(HipA_C)
PF13657
(Couple_hipA) 		5 VAL A 431
ASP A 430
GLU A 427
LEU A 293
LEU A 297
 None
 1.13A 6ew0F-4pu5A:
undetectable		 6ew0F-4pu5A:
11.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qmk TYPE III SECRETION
SYSTEM EFFECTOR
PROTEIN EXOU

(Pseudomonas
fluorescens) 		PF01734
(Patatin) 		5 VAL A  45
LEU A 458
ALA A 432
LEU A 441
LEU A  35
 None
 1.14A 6ew0F-4qmkA:
undetectable		 6ew0F-4qmkA:
9.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qtq XAC2610 PROTEIN

(Xanthomonas
citri) 		no annotation 5 ASP A 137
LEU A 179
ASP A 155
LEU A 193
LEU A 203
 None
None
CA  A 301 (-2.9A)
None
None
 1.17A 6ew0F-4qtqA:
undetectable		 6ew0F-4qtqA:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qxe LEUCINE-RICH
REPEAT-CONTAINING
G-PROTEIN COUPLED
RECEPTOR 4, LINKER,
VARIABLE LYMPHOCYTE
RECEPTOR B

(Eptatretus
burgeri;
Homo sapiens) 		PF01462
(LRRNT)
PF11921
(DUF3439)
PF13516
(LRR_6)
PF13855
(LRR_8) 		5 LEU A  93
ALA A 124
LEU A 117
GLN A 113
LEU A 134
 None
 1.03A 6ew0F-4qxeA:
undetectable		 6ew0F-4qxeA:
10.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qxf LEUCINE-RICH
REPEAT-CONTAINING
G-PROTEIN COUPLED
RECEPTOR 4, VARIABLE
LYMPHOCYTE RECEPTOR
B

(Eptatretus
burgeri;
Homo sapiens) 		PF01462
(LRRNT)
PF11921
(DUF3439)
PF13855
(LRR_8) 		5 LEU A  93
ALA A 124
LEU A 117
GLN A 113
LEU A 134
 None
 1.20A 6ew0F-4qxfA:
undetectable		 6ew0F-4qxfA:
14.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rq9 PHOTORECEPTOR-HISTID
INE KINASE BPHP

(Stigmatella
aurantiaca) 		PF01590
(GAF)
PF08446
(PAS_2) 		5 ASP A 105
LEU A  84
SER A 126
LEU A 121
LEU A  56
 None
None
GOL  A 415 ( 4.3A)
None
None
 1.18A 6ew0F-4rq9A:
undetectable		 6ew0F-4rq9A:
14.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4toi 30S RIBOSOMAL
PROTEIN S2,RIBOSOMAL
PROTEIN S1

(Escherichia
coli) 		PF00318
(Ribosomal_S2)
PF00575
(S1) 		5 VAL A 196
ASP A 197
LEU A 214
GLN A  89
LEU A  57
 None
 1.06A 6ew0F-4toiA:
undetectable		 6ew0F-4toiA:
14.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uip REPEBODY (RAC1)

(Eptatretus
burgeri;
Listeria
monocytogenes;
synthetic
construct) 		PF11921
(DUF3439)
PF12354
(Internalin_N)
PF13855
(LRR_8) 		5 ASP B  78
LEU B 133
ASP B 107
LEU B 112
LEU B  93
 None
 1.06A 6ew0F-4uipB:
undetectable		 6ew0F-4uipB:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wfc EXOSOME COMPLEX
PROTEIN LRP1

(Saccharomyces
cerevisiae) 		PF04000
(Sas10_Utp3) 		5 LEU B  37
ALA B  54
SER B  58
LEU B  33
LEU B  28
 None
 1.18A 6ew0F-4wfcB:
undetectable		 6ew0F-4wfcB:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yzg PROTEIN PHOSPHATASE
2C 57

(Arabidopsis
thaliana) 		PF00481
(PP2C) 		5 VAL A  91
ASP A  75
ALA A 294
SER A 181
LEU A 328
 None
 1.14A 6ew0F-4yzgA:
undetectable		 6ew0F-4yzgA:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ao0 DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1

(Homo sapiens) 		PF01966
(HD) 		5 VAL A 310
ASP A 311
LEU A 128
ALA A 175
LEU A 132
 None
FE  A1001 ( 2.6A)
None
None
None
 1.23A 6ew0F-5ao0A:
undetectable		 6ew0F-5ao0A:
9.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b4p REPEBODY

(synthetic
construct) 		PF11921
(DUF3439)
PF12354
(Internalin_N)
PF13855
(LRR_8) 		5 ASP A  77
LEU A 131
ASP A 105
LEU A 110
LEU A  92
 SO4  A 302 (-4.4A)
None
None
None
None
 1.18A 6ew0F-5b4pA:
undetectable		 6ew0F-5b4pA:
15.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d01 N-ACETYL-ALPHA-D-GLU
COSAMINYL L-MALATE
SYNTHASE

(Bacillus
subtilis) 		PF00534
(Glycos_transf_1)
PF13439
(Glyco_transf_4) 		5 ASP A 161
GLU A 158
ASP A 136
LEU A  97
LEU A 120
 None
 1.24A 6ew0F-5d01A:
undetectable		 6ew0F-5d01A:
13.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dih MICROCOMPARTMENTS
PROTEIN

(Haliangium
ochraceum) 		PF00936
(BMC) 		5 GLU A  26
LEU A 140
ALA A 132
LEU A 147
LEU A 105
 None
 1.19A 6ew0F-5dihA:
undetectable		 6ew0F-5dihA:
14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dn6 ATP SYNTHASE SUBUNIT
ALPHA

(Paracoccus
denitrificans) 		PF00006
(ATP-synt_ab)
PF00306
(ATP-synt_ab_C)
PF02874
(ATP-synt_ab_N) 		5 LEU A 272
ASP A 270
ALA A 251
LEU A 306
LEU A 322
 None
MG  A 601 ( 3.9A)
None
None
None
 1.14A 6ew0F-5dn6A:
2.5		 6ew0F-5dn6A:
11.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f7v LMO0181 PROTEIN

(Listeria
monocytogenes) 		PF01547
(SBP_bac_1) 		5 VAL A 149
ASP A 358
SER A 366
LEU A 352
LEU A 339
 None
 1.23A 6ew0F-5f7vA:
undetectable		 6ew0F-5f7vA:
11.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fcl CRISPR-ASSOCIATED
ENDONUCLEASE CAS1

(Pectobacterium
atrosepticum) 		PF01867
(Cas_Cas1) 		5 LEU A 247
ASP A 119
ALA A 133
LEU A 263
LEU A 270
 None
 1.08A 6ew0F-5fclA:
undetectable		 6ew0F-5fclA:
12.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5giu PROLINE DIPEPTIDASE

(Deinococcus
radiodurans) 		PF00557
(Peptidase_M24)
PF01321
(Creatinase_N) 		5 ASP A 240
ASP A 329
ALA A 248
LEU A 283
LEU A 270
 None
 1.21A 6ew0F-5giuA:
undetectable		 6ew0F-5giuA:
11.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gs2 REPEBODY

(Escherichia
coli) 		PF11921
(DUF3439)
PF12354
(Internalin_N)
PF13855
(LRR_8) 		5 ASP B  77
LEU B 132
ASP B 106
LEU B 111
LEU B  92
 None
 1.14A 6ew0F-5gs2B:
undetectable		 6ew0F-5gs2B:
13.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iv8 LPS BIOSYNTHESIS
PROTEIN

(Klebsiella
pneumoniae) 		PF04453
(OstA_C) 		5 ASP A 629
GLU A 658
LEU A 536
ALA A 632
SER A 656
 None
 1.02A 6ew0F-5iv8A:
undetectable		 6ew0F-5iv8A:
9.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ivl DEAD-BOX
ATP-DEPENDENT RNA
HELICASE CSHA

(Geobacillus
stearothermophilus) 		no annotation 5 VAL B  42
ASP B  41
GLU B 201
LEU B   9
LEU B   7
 None
 1.04A 6ew0F-5ivlB:
undetectable		 6ew0F-5ivlB:
10.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jzb 4,5:9,10-DISECO-3-HY
DROXY-5,9,17-TRIOXOA
NDROSTA-1(10),2-DIEN
E-4-OATE HYDROLASE

(Mycobacterium
tuberculosis) 		PF12697
(Abhydrolase_6) 		5 LEU A 105
ASP A 101
SER A  79
LEU A  69
LEU A  42
 None
 1.19A 6ew0F-5jzbA:
2.9		 6ew0F-5jzbA:
15.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lb8 ATP-DEPENDENT DNA
HELICASE Q5

(Homo sapiens) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF16124
(RecQ_Zn_bind) 		5 ASP A  85
ASP A 353
ALA A  56
SER A  59
LEU A  93
 None
 1.08A 6ew0F-5lb8A:
undetectable		 6ew0F-5lb8A:
9.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lpy PROTEIN
BRASSINOSTEROID
INSENSITIVE 1

(Arabidopsis
thaliana) 		PF00069
(Pkinase) 		5 LEU A1127
ALA A 987
SER A 990
LEU A1080
LEU A 968
 None
 0.97A 6ew0F-5lpyA:
undetectable		 6ew0F-5lpyA:
12.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lpz PROTEIN
BRASSINOSTEROID
INSENSITIVE 1

(Arabidopsis
thaliana) 		PF00069
(Pkinase) 		5 LEU A1127
ALA A 987
SER A 990
LEU A1080
LEU A 968
 None
 1.06A 6ew0F-5lpzA:
undetectable		 6ew0F-5lpzA:
12.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lst ATP-DEPENDENT DNA
HELICASE Q4

(Homo sapiens) 		PF00270
(DEAD)
PF00271
(Helicase_C) 		5 VAL A 783
ASP A 782
LEU A 720
ALA A 785
LEU A 692
 None
 1.10A 6ew0F-5lstA:
undetectable		 6ew0F-5lstA:
7.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5mjs TUBULIN BETA CHAIN

(Schizosaccharomyces
pombe) 		no annotation 6 ASP A  26
LEU A 215
ASP A 224
HIS A 227
ALA A 231
LEU A 360
 None
 1.01A 6ew0F-5mjsA:
59.4		 6ew0F-5mjsA:
75.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5mjs TUBULIN BETA CHAIN

(Schizosaccharomyces
pombe) 		no annotation 5 ASP A  26
LEU A 215
ASP A 224
LEU A 272
LEU A 360
 None
 0.85A 6ew0F-5mjsA:
59.4		 6ew0F-5mjsA:
75.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5mjs TUBULIN BETA CHAIN

(Schizosaccharomyces
pombe) 		no annotation 6 GLU A  27
LEU A 215
ASP A 224
HIS A 227
ALA A 231
LEU A 360
 None
 1.03A 6ew0F-5mjsA:
59.4		 6ew0F-5mjsA:
75.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5mjs TUBULIN BETA CHAIN

(Schizosaccharomyces
pombe) 		no annotation 5 GLU A  27
LEU A 215
ASP A 224
LEU A 272
LEU A 360
 None
 0.90A 6ew0F-5mjsA:
59.4		 6ew0F-5mjsA:
75.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mog PHYTOENE
DEHYDROGENASE,
CHLOROPLASTIC/CHROMO
PLASTIC

(Oryza sativa) 		PF01593
(Amino_oxidase) 		5 VAL A 138
GLU A 134
LEU A 313
ARG A 180
LEU A 117
 EPE  A 602 (-4.0A)
FAD  A 600 (-2.7A)
None
None
None
 1.23A 6ew0F-5mogA:
undetectable		 6ew0F-5mogA:
10.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5n5n TUBULIN BETA CHAIN

(Homo sapiens) 		no annotation 10 VAL B  23
ASP B  26
GLU B  27
LEU B 217
ASP B 226
HIS B 229
ALA B 233
LEU B 275
GLN B 281
LEU B 371
 None
 0.86A 6ew0F-5n5nB:
62.1		 6ew0F-5n5nB:
93.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5n5n TUBULIN BETA CHAIN

(Homo sapiens) 		no annotation 10 VAL B  23
ASP B  26
GLU B  27
LEU B 217
ASP B 226
HIS B 229
ALA B 233
SER B 236
GLN B 281
LEU B 371
 None
 0.88A 6ew0F-5n5nB:
62.1		 6ew0F-5n5nB:
93.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nh1 GASDERMIN-D

(Homo sapiens) 		PF04598
(Gasdermin) 		5 GLU A 394
LEU A 469
ALA A 392
SER A 395
LEU A 441
 None
 1.13A 6ew0F-5nh1A:
undetectable		 6ew0F-5nh1A:
15.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t81 EPOB

(Sorangium
cellulosum) 		PF00668
(Condensation) 		5 VAL A 205
ASP A 206
LEU A 218
ASP A 216
LEU A 430
 None
 0.81A 6ew0F-5t81A:
undetectable		 6ew0F-5t81A:
8.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uid AMINOTRANSFERASE
TLMJ

(Streptoalloteichus
hindustanus) 		PF01041
(DegT_DnrJ_EryC1) 		5 ALA A 159
SER A 296
ARG A 197
GLN A  51
LEU A  45
 None
 1.09A 6ew0F-5uidA:
undetectable		 6ew0F-5uidA:
12.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w3j TUBULIN BETA CHAIN

(Saccharomyces
cerevisiae) 		PF00091
(Tubulin)
PF03953
(Tubulin_C) 		5 VAL B  23
ASP B  26
GLU B  27
GLN B 279
LEU B 361
 TA1  B 502 (-3.9A)
TA1  B 502 (-4.1A)
TA1  B 502 (-3.6A)
TA1  B 502 ( 4.3A)
TA1  B 502 (-3.7A)
 1.09A 6ew0F-5w3jB:
60.5		 6ew0F-5w3jB:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w3j TUBULIN BETA CHAIN

(Saccharomyces
cerevisiae) 		PF00091
(Tubulin)
PF03953
(Tubulin_C) 		7 VAL B  23
ASP B  26
GLU B  27
LEU B 215
ASP B 224
SER B 234
LEU B 361
 TA1  B 502 (-3.9A)
TA1  B 502 (-4.1A)
TA1  B 502 (-3.6A)
None
None
TA1  B 502 ( 4.9A)
TA1  B 502 (-3.7A)
 0.80A 6ew0F-5w3jB:
60.5		 6ew0F-5w3jB:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w3j TUBULIN BETA CHAIN

(Saccharomyces
cerevisiae) 		PF00091
(Tubulin)
PF03953
(Tubulin_C) 		5 VAL B  23
ASP B  26
GLU B  27
LEU B 273
SER B 234
 TA1  B 502 (-3.9A)
TA1  B 502 (-4.1A)
TA1  B 502 (-3.6A)
None
TA1  B 502 ( 4.9A)
 1.24A 6ew0F-5w3jB:
60.5		 6ew0F-5w3jB:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w4b ADENOSYLHOMOCYSTEINA
SE

(Homo sapiens) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		5 GLU A 105
LEU A 344
SER A  78
LEU A 347
GLN A 324
 None
NAD  A 501 (-4.0A)
None
9W4  A 502 (-4.1A)
9W4  A 502 (-4.2A)
 1.15A 6ew0F-5w4bA:
6.1		 6ew0F-5w4bA:
10.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x8g 2-SUCCINYLBENZOATE--
COA LIGASE

(Bacillus
subtilis) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		5 VAL A 124
ASP A 123
ALA A  69
LEU A  82
ARG A  92
 None
 1.23A 6ew0F-5x8gA:
undetectable		 6ew0F-5x8gA:
10.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y59 ATP-DEPENDENT DNA
HELICASE II SUBUNIT
2

(Saccharomyces
cerevisiae) 		no annotation 5 VAL B 113
ASP B 116
LEU B  87
LEU B  29
ARG B  86
 None
 1.11A 6ew0F-5y59B:
2.7		 6ew0F-5y59B:
16.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y6q ALDEHYDE OXIDASE
MEDIUM SUBUNIT

(Methylobacillus
sp. KY4400) 		no annotation 5 LEU B  59
ALA B  87
SER B 228
LEU B  77
LEU B 170
 None
 0.84A 6ew0F-5y6qB:
undetectable		 6ew0F-5y6qB:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yl7 PSEUDOALTEROMONAS
ARCTICA PAMC 21717

(Pseudoalteromonas
arctica) 		no annotation 5 VAL A 181
ASP A 310
LEU A 167
LEU A 165
LEU A 454
 None
 1.00A 6ew0F-5yl7A:
undetectable		 6ew0F-5yl7A:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6byi BETA-MANNOSIDASE

(Xanthomonas
citri) 		no annotation 5 VAL A 460
ASP A 523
ASP A 434
ALA A 456
LEU A 510
 None
 1.11A 6ew0F-6byiA:
undetectable		 6ew0F-6byiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1biy LACTOFERRIN

(Bubalus bubalis) 		PF00405
(Transferrin) 		4 LEU A 451
LEU A 589
THR A 577
ARG A 566
 None
 0.92A 6ew0F-1biyA:
0.0		 6ew0F-1biyA:
7.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gkr NON-ATP DEPENDENT
L-SELECTIVE
HYDANTOINASE

(Paenarthrobacter
aurescens) 		PF01979
(Amidohydro_1) 		4 LEU A 360
LEU A 392
THR A 347
ARG A 406
 None
 1.11A 6ew0F-1gkrA:
0.0		 6ew0F-1gkrA:
11.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1htj KIAA0380

(Homo sapiens) 		PF09128
(RGS-like) 		4 LEU F 324
THR F 478
PRO F 374
ARG F 376
 None
 1.09A 6ew0F-1htjF:
undetectable		 6ew0F-1htjF:
15.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i7q ANTHRANILATE
SYNTHASE

(Serratia
marcescens) 		PF00425
(Chorismate_bind)
PF04715
(Anth_synt_I_N) 		4 LEU A 127
LEU A 154
THR A  67
ARG A 169
 None
 0.98A 6ew0F-1i7qA:
0.0		 6ew0F-1i7qA:
10.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iq0 ARGINYL-TRNA
SYNTHETASE

(Thermus
thermophilus) 		PF00750
(tRNA-synt_1d)
PF03485
(Arg_tRNA_synt_N)
PF05746
(DALR_1) 		4 LEU A 160
THR A 152
PRO A 337
ARG A 322
 None
 0.95A 6ew0F-1iq0A:
0.0		 6ew0F-1iq0A:
9.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jct GLUCARATE
DEHYDRATASE

(Escherichia
coli) 		PF13378
(MR_MLE_C) 		4 LEU A 378
THR A  37
PRO A 163
ARG A 157
 None
 0.97A 6ew0F-1jctA:
3.1		 6ew0F-1jctA:
11.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kgs DNA BINDING RESPONSE
REGULATOR D

(Thermotoga
maritima) 		PF00072
(Response_reg)
PF00486
(Trans_reg_C) 		4 LEU A 110
LEU A  14
THR A  81
PRO A  57
 None
 1.06A 6ew0F-1kgsA:
0.8		 6ew0F-1kgsA:
16.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lu4 SOLUBLE SECRETED
ANTIGEN MPT53

(Mycobacterium
tuberculosis) 		PF00578
(AhpC-TSA) 		4 LEU A1079
LEU A1012
THR A1033
ARG A1094
 None
 1.03A 6ew0F-1lu4A:
1.8		 6ew0F-1lu4A:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n7d LOW-DENSITY
LIPOPROTEIN RECEPTOR

(Homo sapiens) 		PF00057
(Ldl_recept_a)
PF00058
(Ldl_recept_b)
PF07645
(EGF_CA)
PF14670
(FXa_inhibition) 		4 LEU A 661
THR A 489
PRO A 498
ARG A 499
 None
 0.93A 6ew0F-1n7dA:
undetectable		 6ew0F-1n7dA:
8.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p43 ENOLASE 1

(Saccharomyces
cerevisiae) 		PF00113
(Enolase_C)
PF03952
(Enolase_N) 		4 LEU A 115
LEU A 133
THR A 381
PRO A 147
 None
 1.06A 6ew0F-1p43A:
0.2		 6ew0F-1p43A:
12.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qi9 PROTEIN (VANADIUM
BROMOPEROXIDASE)

(Ascophyllum
nodosum) 		no annotation 4 LEU A 380
LEU A 146
THR A 397
ARG A 349
 None
None
None
VO4  A 600 (-2.7A)
 1.05A 6ew0F-1qi9A:
undetectable		 6ew0F-1qi9A:
9.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qzg PROTECTION OF
TELOMERES PROTEIN 1

(Schizosaccharomyces
pombe) 		PF02765
(POT1) 		4 LEU A  45
LEU A  87
THR A 111
ARG A 116
 None
 1.08A 6ew0F-1qzgA:
undetectable		 6ew0F-1qzgA:
14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vkz PHOSPHORIBOSYLAMINE-
-GLYCINE LIGASE

(Thermotoga
maritima) 		PF01071
(GARS_A)
PF02843
(GARS_C)
PF02844
(GARS_N) 		4 LEU A 338
LEU A 321
PRO A 281
ARG A  14
 None
 0.89A 6ew0F-1vkzA:
1.4		 6ew0F-1vkzA:
12.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wn9 THE HYPOTHETICAL
PROTEIN (TT1805)

(Thermus
thermophilus) 		PF11432
(DUF3197) 		4 LEU A 102
LEU A  58
THR A  35
ARG A  88
 None
 1.07A 6ew0F-1wn9A:
undetectable		 6ew0F-1wn9A:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wwl MONOCYTE
DIFFERENTIATION
ANTIGEN CD14

(Mus musculus) 		no annotation 4 LEU A 128
LEU A  91
THR A  76
ARG A  81
 None
 1.03A 6ew0F-1wwlA:
undetectable		 6ew0F-1wwlA:
12.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xv9 ORPHAN NUCLEAR
RECEPTOR NR1I3

(Homo sapiens) 		PF00104
(Hormone_recep) 		4 LEU B 242
LEU B 206
THR B 225
ARG B 136
 None
 1.09A 6ew0F-1xv9B:
undetectable		 6ew0F-1xv9B:
15.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cge ATP-DEPENDENT
MOLECULAR CHAPERONE
HSP82

(Saccharomyces
cerevisiae) 		PF00183
(HSP90) 		4 LEU A 558
LEU A 651
THR A 612
PRO A 486
 None
 0.82A 6ew0F-2cgeA:
undetectable		 6ew0F-2cgeA:
12.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ch1 3-HYDROXYKYNURENINE
TRANSAMINASE

(Anopheles
gambiae) 		PF00266
(Aminotran_5) 		4 LEU A 176
LEU A 135
THR A 150
ARG A 311
 None
 1.10A 6ew0F-2ch1A:
undetectable		 6ew0F-2ch1A:
11.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gwr DNA-BINDING RESPONSE
REGULATOR MTRA

(Mycobacterium
tuberculosis) 		PF00072
(Response_reg)
PF00486
(Trans_reg_C) 		4 LEU A 112
LEU A  17
THR A  83
PRO A  60
 None
 1.04A 6ew0F-2gwrA:
undetectable		 6ew0F-2gwrA:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mcp IGA-KAPPA MCPC603
FAB (HEAVY CHAIN)

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 LEU H  18
THR H 117
PRO H 128
ARG H 126
 None
 1.05A 6ew0F-2mcpH:
undetectable		 6ew0F-2mcpH:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nzx ALPHA1,3-FUCOSYLTRAN
SFERASE

(Helicobacter
pylori) 		PF00852
(Glyco_transf_10) 		4 LEU A  69
LEU A  51
THR A 337
ARG A 121
 None
 1.10A 6ew0F-2nzxA:
undetectable		 6ew0F-2nzxA:
11.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qqk NEUROPILIN-2

(Homo sapiens) 		PF00431
(CUB)
PF00754
(F5_F8_type_C) 		4 LEU A 441
LEU A 590
THR A 337
PRO A 271
 None
 0.95A 6ew0F-2qqkA:
undetectable		 6ew0F-2qqkA:
10.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r0l HEPATOCYTE GROWTH
FACTOR ACTIVATOR

(Homo sapiens) 		PF00089
(Trypsin)
no annotation 		4 LEU A 105
LEU A 123
THR A  49
PRO B 388
 None
 1.02A 6ew0F-2r0lA:
undetectable		 6ew0F-2r0lA:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xnd ATP SYNTHASE SUBUNIT
DELTA, MITOCHONDRIAL
ATP SYNTHASE SUBUNIT
EPSILON,
MITOCHONDRIAL

(Bos taurus) 		PF02823
(ATP-synt_DE_N)
PF04627
(ATP-synt_Eps) 		4 LEU I  26
LEU H 141
THR H  99
PRO H  39
 None
 1.06A 6ew0F-2xndI:
undetectable		 6ew0F-2xndI:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ycb CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR

(Methanothermobacter
thermautotrophicus) 		PF07521
(RMMBL)
PF10996
(Beta-Casp)
PF16661
(Lactamase_B_6)
PF17214
(KH_7) 		4 LEU A 196
LEU A 338
THR A 350
PRO A 594
 None
 0.91A 6ew0F-2ycbA:
undetectable		 6ew0F-2ycbA:
9.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yx0 RADICAL SAM ENZYME

(Pyrococcus
horikoshii) 		PF04055
(Radical_SAM)
PF08608
(Wyosine_form) 		4 LEU A 231
LEU A 198
THR A 180
PRO A  76
 None
 1.09A 6ew0F-2yx0A:
3.3		 6ew0F-2yx0A:
12.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zbw THIOREDOXIN
REDUCTASE

(Thermus
thermophilus) 		PF07992
(Pyr_redox_2) 		4 LEU A 237
LEU A 156
THR A 210
ARG A 205
 None
 0.94A 6ew0F-2zbwA:
undetectable		 6ew0F-2zbwA:
12.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3af5 PUTATIVE
UNCHARACTERIZED
PROTEIN PH1404

(Pyrococcus
horikoshii) 		PF07521
(RMMBL)
PF10996
(Beta-Casp)
PF16661
(Lactamase_B_6)
PF17214
(KH_7) 		4 LEU A 205
LEU A 353
THR A 365
PRO A 609
 None
 1.00A 6ew0F-3af5A:
undetectable		 6ew0F-3af5A:
8.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aov PUTATIVE
UNCHARACTERIZED
PROTEIN PH0207

(Pyrococcus
horikoshii) 		PF00155
(Aminotran_1_2) 		4 LEU A 318
LEU A 111
THR A 266
PRO A 204
 None
None
PLP  A 429 (-3.1A)
None
 1.06A 6ew0F-3aovA:
undetectable		 6ew0F-3aovA:
12.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cai POSSIBLE
AMINOTRANSFERASE

(Mycobacterium
tuberculosis) 		PF00266
(Aminotran_5) 		4 LEU A 394
LEU A 307
THR A 375
PRO A 323
 None
 0.91A 6ew0F-3caiA:
undetectable		 6ew0F-3caiA:
11.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e9d ZGC:56074

(Danio rerio) 		PF00300
(His_Phos_1) 		4 LEU A 139
LEU A 194
THR A   7
PRO A 161
 None
 0.99A 6ew0F-3e9dA:
undetectable		 6ew0F-3e9dA:
15.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fd2 SITE-SPECIFIC DNA
ENDONUCLEASE I-MSOI

(Monomastix sp.
OKE-1) 		PF00961
(LAGLIDADG_1) 		4 LEU A 268
LEU A 222
THR A 286
ARG A 254
 None
 1.11A 6ew0F-3fd2A:
undetectable		 6ew0F-3fd2A:
12.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g87 MALONYL COA-ACYL
CARRIER PROTEIN
TRANSACYLASE

(Burkholderia
pseudomallei) 		PF00698
(Acyl_transf_1) 		4 LEU A  32
LEU A 100
THR A  73
PRO A  85
 None
 1.05A 6ew0F-3g87A:
undetectable		 6ew0F-3g87A:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gl5 PUTATIVE DSBA
OXIDOREDUCTASE
SCO1869

(Streptomyces
coelicolor) 		PF01323
(DSBA) 		4 LEU A 157
LEU A 117
THR A  98
ARG A  89
 None
 1.08A 6ew0F-3gl5A:
undetectable		 6ew0F-3gl5A:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hjc HEAT SHOCK PROTEIN
83-1

(Leishmania
major) 		PF00183
(HSP90) 		4 LEU A 287
LEU A 379
THR A 341
PRO A 214
 None
 1.03A 6ew0F-3hjcA:
undetectable		 6ew0F-3hjcA:
10.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hrd NICOTINATE
DEHYDROGENASE LARGE
MOLYBDOPTERIN
SUBUNIT
NICOTINATE
DEHYDROGENASE MEDIUM
MOLYBDOPTERIN
SUBUNIT

(Eubacterium
barkeri) 		PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2) 		4 LEU B  91
THR B  18
PRO B 290
ARG A 351
 None
NIO  B5661 (-3.9A)
None
MCN  B 921 ( 4.0A)
 1.09A 6ew0F-3hrdB:
undetectable		 6ew0F-3hrdB:
14.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hrp UNCHARACTERIZED
PROTEIN

(Bacteroides
thetaiotaomicron) 		PF01833
(TIG) 		4 LEU A 254
THR A 216
PRO A 173
ARG A 176
 None
EDO  A  15 (-3.2A)
None
None
 1.03A 6ew0F-3hrpA:
undetectable		 6ew0F-3hrpA:
12.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j2s COAGULATION FACTOR
VIII LIGHT CHAIN

(Homo sapiens) 		PF00754
(F5_F8_type_C)
PF07731
(Cu-oxidase_2) 		4 LEU B2306
LEU B2178
THR B2237
ARG B2147
 None
 1.09A 6ew0F-3j2sB:
undetectable		 6ew0F-3j2sB:
8.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l12 PUTATIVE
GLYCEROPHOSPHORYL
DIESTER
PHOSPHODIESTERASE

(Ruegeria
pomeroyi) 		PF03009
(GDPD) 		4 LEU A 207
LEU A 146
THR A 272
PRO A 297
 UNL  A 317 ( 4.5A)
None
None
None
 1.05A 6ew0F-3l12A:
undetectable		 6ew0F-3l12A:
13.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ldt OUTER MEMBRANE
PROTEIN, OMPA FAMILY
PROTEIN

(Legionella
pneumophila) 		PF00691
(OmpA) 		4 LEU A 155
LEU A 109
THR A 124
ARG A 227
 None
 1.09A 6ew0F-3ldtA:
undetectable		 6ew0F-3ldtA:
17.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lxq UNCHARACTERIZED
PROTEIN VP1736

(Vibrio
parahaemolyticus) 		PF00884
(Sulfatase) 		4 LEU A 287
THR A 548
PRO A 344
ARG A 334
 None
None
None
CL  A   1 (-4.5A)
 1.07A 6ew0F-3lxqA:
undetectable		 6ew0F-3lxqA:
11.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mzs CHOLESTEROL
SIDE-CHAIN CLEAVAGE
ENZYME

(Bos taurus) 		PF00067
(p450) 		4 LEU A 300
THR A 434
PRO A 398
ARG A 400
 None
 0.96A 6ew0F-3mzsA:
undetectable		 6ew0F-3mzsA:
12.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n0g ISOPRENE SYNTHASE

(Populus tremula
x Populus alba) 		PF01397
(Terpene_synth)
PF03936
(Terpene_synth_C) 		4 LEU A 386
LEU A 450
THR A 342
ARG A 331
 None
 1.01A 6ew0F-3n0gA:
undetectable		 6ew0F-3n0gA:
9.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3na0 CHOLESTEROL
SIDE-CHAIN CLEAVAGE
ENZYME,
MITOCHONDRIAL

(Homo sapiens) 		PF00067
(p450) 		4 LEU A 339
THR A 473
PRO A 437
ARG A 439
 None
 0.98A 6ew0F-3na0A:
undetectable		 6ew0F-3na0A:
11.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nhz TWO COMPONENT SYSTEM
TRANSCRIPTIONAL
REGULATOR MTRA

(Mycobacterium
tuberculosis) 		PF00072
(Response_reg) 		4 LEU A 112
LEU A  17
THR A  83
PRO A  60
 None
 0.95A 6ew0F-3nhzA:
undetectable		 6ew0F-3nhzA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nxl GLUCARATE
DEHYDRATASE

(Burkholderia
lata) 		PF13378
(MR_MLE_C) 		4 LEU A 398
THR A  41
PRO A 183
ARG A 177
 None
 1.09A 6ew0F-3nxlA:
2.3		 6ew0F-3nxlA:
10.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p0w MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN

(Ralstonia
pickettii) 		PF13378
(MR_MLE_C) 		4 LEU A 394
THR A  37
PRO A 179
ARG A 173
 None
 1.11A 6ew0F-3p0wA:
2.3		 6ew0F-3p0wA:
11.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pls MACROPHAGE-STIMULATI
NG PROTEIN RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LEU A1300
LEU A1306
THR A1254
ARG A1245
 None
 1.11A 6ew0F-3plsA:
undetectable		 6ew0F-3plsA:
15.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3shq UBLCP1

(Drosophila
melanogaster) 		PF00240
(ubiquitin)
PF03031
(NIF) 		4 LEU A 286
LEU A 145
THR A 174
ARG A 198
 None
 1.11A 6ew0F-3shqA:
undetectable		 6ew0F-3shqA:
15.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3skd PUTATIVE
UNCHARACTERIZED
PROTEIN TTHB187

(Thermus
thermophilus) 		no annotation 4 LEU A 230
LEU A 176
THR A  28
ARG A 196
 None
 1.08A 6ew0F-3skdA:
undetectable		 6ew0F-3skdA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tch PERIPLASMIC
OLIGOPEPTIDE-BINDING
PROTEIN

(Escherichia
coli) 		PF00496
(SBP_bac_5) 		4 LEU A 499
LEU A 353
THR A 450
PRO A 529
 None
 1.04A 6ew0F-3tchA:
undetectable		 6ew0F-3tchA:
9.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u9s METHYLCROTONYL-COA
CARBOXYLASE,
ALPHA-SUBUNIT

(Pseudomonas
aeruginosa) 		PF00289
(Biotin_carb_N)
PF00364
(Biotin_lipoyl)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		4 LEU A 612
THR A 458
PRO A 391
ARG A 464
 None
 1.08A 6ew0F-3u9sA:
undetectable		 6ew0F-3u9sA:
9.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w9s OMPR FAMILY RESPONSE
REGULATOR IN
TWO-COMPONENT
REGULATORY SYSTEM
WITH BASS

(Klebsiella
pneumoniae) 		PF00072
(Response_reg) 		4 LEU A 108
LEU A  12
THR A  79
PRO A  55
 None
None
BEF  A 201 (-3.7A)
None
 1.01A 6ew0F-3w9sA:
undetectable		 6ew0F-3w9sA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fdd TRANSPORTIN-1

(Homo sapiens) 		PF03810
(IBN_N)
PF13513
(HEAT_EZ) 		4 LEU A 293
LEU A 304
THR A 282
ARG A 232
 None
 1.05A 6ew0F-4fddA:
1.8		 6ew0F-4fddA:
6.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fim LACTOTRANSFERRIN

(Bos taurus) 		PF00405
(Transferrin) 		4 LEU A 451
LEU A 589
THR A 577
ARG A 566
 GOL  A 712 ( 4.7A)
None
None
NAG  A 710 ( 4.7A)
 1.02A 6ew0F-4fimA:
undetectable		 6ew0F-4fimA:
12.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g2t SSFS6

(Streptomyces
sp. SF2575) 		PF00201
(UDPGT)
PF06722
(DUF1205) 		4 LEU A 237
LEU A 245
THR A 218
PRO A 307
 None
 1.06A 6ew0F-4g2tA:
undetectable		 6ew0F-4g2tA:
11.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4glp MONOCYTE
DIFFERENTIATION
ANTIGEN CD14

(Homo sapiens) 		PF13516
(LRR_6) 		4 LEU A 164
LEU A 172
THR A 122
ARG A 117
 None
 1.06A 6ew0F-4glpA:
undetectable		 6ew0F-4glpA:
12.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gyp GLUCARATE
DEHYDRATASE-RELATED
PROTEIN

(Escherichia
coli) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 LEU C 377
THR C  36
PRO C 162
ARG C 156
 None
 1.04A 6ew0F-4gypC:
undetectable		 6ew0F-4gypC:
10.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hn8 D-GLUCARATE
DEHYDRATASE

(Pseudomonas
mendocina) 		PF13378
(MR_MLE_C) 		4 LEU A 395
THR A  39
PRO A 180
ARG A 174
 None
 1.05A 6ew0F-4hn8A:
undetectable		 6ew0F-4hn8A:
9.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hst GLUTARYL-7-AMINOCEPH
ALOSPORANIC ACID
ACYLASE ALPHA CHAIN
GLUTARYL-7-AMINOCEPH
ALOSPORANIC ACID
ACYLASE BETA CHAIN

(Pseudomonas) 		PF01804
(Penicil_amidase) 		4 LEU B 399
LEU B 390
THR B 344
ARG A 190
 None
 1.01A 6ew0F-4hstB:
undetectable		 6ew0F-4hstB:
11.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hyr GLUCARATE
DEHYDRATASE

(Acidaminococcus
intestini) 		PF13378
(MR_MLE_C) 		4 LEU A 374
THR A  32
PRO A 159
ARG A 153
 None
 0.99A 6ew0F-4hyrA:
undetectable		 6ew0F-4hyrA:
11.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i0k CD276 ANTIGEN

(Mus musculus) 		PF07686
(V-set)
PF13927
(Ig_3) 		4 LEU A 212
LEU A 208
THR A 217
PRO A 145
 None
None
SO4  A 307 (-4.4A)
None
 0.92A 6ew0F-4i0kA:
undetectable		 6ew0F-4i0kA:
16.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4il1 CALMODULIN,
CALCINEURIN SUBUNIT
B TYPE 1,
SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2B
CATALYTIC SUBUNIT
ALPHA ISOFORM

(Rattus
norvegicus) 		PF00149
(Metallophos)
PF13499
(EF-hand_7) 		4 LEU A 466
THR A 476
PRO A 374
ARG A 375
 None
 1.08A 6ew0F-4il1A:
undetectable		 6ew0F-4il1A:
7.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ld7 DIMETHYLALLYL
TRYPTOPHAN SYNTHASE

(Aspergillus
fischeri) 		PF11991
(Trp_DMAT) 		4 LEU A 360
LEU A 318
THR A 424
PRO A 354
 NA  A 502 (-4.5A)
None
None
None
 1.10A 6ew0F-4ld7A:
undetectable		 6ew0F-4ld7A:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n2x DL-2-HALOACID
DEHALOGENASE

(Methylobacterium
sp. CPA1) 		PF10778
(DehI) 		4 LEU A 213
LEU A 110
THR A 278
PRO A  36
 None
 1.11A 6ew0F-4n2xA:
undetectable		 6ew0F-4n2xA:
14.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o6x ANKYRIN-3

(Homo sapiens) 		PF00531
(Death) 		4 LEU A  26
LEU A  15
THR A  69
ARG A   3
 None
 1.06A 6ew0F-4o6xA:
undetectable		 6ew0F-4o6xA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pag PERIPLASMIC BINDING
PROTEIN

(Sulfurospirillum
deleyianum) 		PF01497
(Peripla_BP_2) 		4 LEU A 340
LEU A 295
PRO A 288
ARG A 287
 None
 0.91A 6ew0F-4pagA:
undetectable		 6ew0F-4pagA:
13.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ptz FMN REDUCTASE SSUE

(Escherichia
coli) 		no annotation 4 LEU C  63
LEU C  87
THR C   4
PRO C  74
 None
None
None
FMN  C 201 (-4.1A)
 1.01A 6ew0F-4ptzC:
undetectable		 6ew0F-4ptzC:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pxn UNCHARACTERIZED
PROTEIN

(Zea mays) 		PF00171
(Aldedh) 		4 LEU A  15
LEU A  92
THR A 198
ARG A 300
 None
 1.10A 6ew0F-4pxnA:
undetectable		 6ew0F-4pxnA:
10.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pyr PUTATIVE
BRANCHED-CHAIN AMINO
ACID ABC TRANSPORTER

(Chromobacterium
violaceum) 		PF04348
(LppC) 		4 LEU A 296
THR A 284
PRO A 207
ARG A 237
 None
 1.11A 6ew0F-4pyrA:
undetectable		 6ew0F-4pyrA:
11.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r0b GLYCODELIN

(Homo sapiens) 		PF00061
(Lipocalin) 		4 LEU A  15
LEU A 122
THR A  93
ARG A 138
 None
 1.03A 6ew0F-4r0bA:
undetectable		 6ew0F-4r0bA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rhp UBIQUINONE
BIOSYNTHESIS PROTEIN
COQ9, MITOCHONDRIAL

(Homo sapiens) 		PF08511
(COQ9) 		4 LEU A 193
LEU A 204
THR A 254
ARG A 244
 None
None
None
PEF  A 401 (-3.9A)
 1.11A 6ew0F-4rhpA:
undetectable		 6ew0F-4rhpA:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yeb FIBRONECTIN LEUCINE
RICH TRANSMEMBRANE
PROTEIN 3

(Mus musculus) 		PF13855
(LRR_8) 		4 LEU B 195
LEU B 232
THR B 189
ARG B 163
 None
 1.01A 6ew0F-4yebB:
undetectable		 6ew0F-4yebB:
11.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zqv CDII IMMUNITY
PROTEIN

(Yersinia
kristensenii) 		PF07262
(CdiI) 		4 LEU A 156
LEU A  58
THR A 118
ARG A  29
 None
 1.09A 6ew0F-4zqvA:
undetectable		 6ew0F-4zqvA:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b7i CRISPR-ASSOCIATED
NUCLEASE/HELICASE
CAS3 SUBTYPE
I-F/YPEST

(Pseudomonas
aeruginosa) 		no annotation 4 LEU A 717
LEU A 735
THR A 712
ARG A 870
 None
 1.10A 6ew0F-5b7iA:
undetectable		 6ew0F-5b7iA:
5.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e25 BRANCHED-CHAIN
AMINOTRANSFERASE

(Geoglobus
acetivorans) 		PF01063
(Aminotran_4) 		4 LEU A 123
LEU A 132
THR A 246
ARG A 140
 None
 1.10A 6ew0F-5e25A:
undetectable		 6ew0F-5e25A:
16.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e3j RESPONSE REGULATOR
RSTA

(Acinetobacter
baumannii) 		PF00072
(Response_reg) 		4 LEU A 114
LEU A  19
THR A  85
PRO A  62
 None
 1.00A 6ew0F-5e3jA:
undetectable		 6ew0F-5e3jA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ez7 FLAVOENZYME PA4991

(Pseudomonas
aeruginosa) 		PF01266
(DAO) 		4 LEU A 238
LEU A 295
THR A 257
ARG A 313
 None
 1.09A 6ew0F-5ez7A:
undetectable		 6ew0F-5ez7A:
13.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fub PROTEIN ARGININE
METHYLTRANSFERASE 2

(Danio rerio) 		PF13649
(Methyltransf_25) 		4 LEU A 373
LEU A 287
THR A 226
ARG A  99
 None
None
EDO  A1414 ( 3.9A)
SAH  A 409 (-2.7A)
 0.94A 6ew0F-5fubA:
undetectable		 6ew0F-5fubA:
14.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ie2 OXALATE--COA LIGASE

(Arabidopsis
thaliana) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		4 LEU A 300
THR A 258
PRO A 235
ARG A 239
 None
 1.05A 6ew0F-5ie2A:
undetectable		 6ew0F-5ie2A:
9.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jj7 ADENOSINE
MONOPHOSPHATE-PROTEI
N TRANSFERASE FICD
HOMOLOG

(Caenorhabditis
elegans) 		PF02661
(Fic) 		4 LEU A 278
LEU A 287
THR A 270
ARG A 336
 None
 1.10A 6ew0F-5jj7A:
undetectable		 6ew0F-5jj7A:
13.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jjt SERINE/THREONINE-PRO
TEIN PHOSPHATASE 5

(Arabidopsis
thaliana) 		PF00149
(Metallophos)
PF00515
(TPR_1)
PF08321
(PPP5)
PF13431
(TPR_17) 		4 LEU A 401
LEU A 349
PRO A 325
ARG A 287
 None
 1.03A 6ew0F-5jjtA:
undetectable		 6ew0F-5jjtA:
11.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lac 3CL PROTEASE

(Alphamesonivirus
1) 		PF17222
(Peptidase_C107) 		4 LEU A  85
LEU A  67
PRO A  21
ARG A  35
 None
 0.90A 6ew0F-5lacA:
undetectable		 6ew0F-5lacA:
12.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5law E3 UBIQUITIN-PROTEIN
LIGASE MDM2

(Homo sapiens) 		PF02201
(SWIB) 		4 LEU A  54
THR A 101
PRO A  30
ARG A  29
 6SJ  A 201 (-4.2A)
None
None
None
 1.06A 6ew0F-5lawA:
undetectable		 6ew0F-5lawA:
17.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5n5n TUBULIN BETA CHAIN

(Homo sapiens) 		no annotation 4 LEU B 219
LEU B 230
THR B 276
PRO B 360
 None
 0.84A 6ew0F-5n5nB:
62.1		 6ew0F-5n5nB:
93.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n9x ADENYLATION DOMAIN

(Streptomyces
sp.) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		4 LEU A  86
THR A  19
PRO A 153
ARG A  66
 None
 1.09A 6ew0F-5n9xA:
undetectable		 6ew0F-5n9xA:
9.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5sy5 ARYL HYDROCARBON
RECEPTOR NUCLEAR
TRANSLOCATOR
NEURONAL PAS
DOMAIN-CONTAINING
PROTEIN 1

(Mus musculus) 		PF00010
(HLH)
PF00989
(PAS)
PF08447
(PAS_3)
PF14598
(PAS_11) 		4 LEU A 167
LEU B 143
THR A 160
PRO B  75
 None
 1.10A 6ew0F-5sy5A:
undetectable		 6ew0F-5sy5A:
10.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5udh E3 UBIQUITIN-PROTEIN
LIGASE ARIH1

(Homo sapiens) 		PF01485
(IBR) 		4 LEU A 216
LEU A 201
THR A 228
PRO A 127
 None
 0.99A 6ew0F-5udhA:
undetectable		 6ew0F-5udhA:
10.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uic TWO-COMPONENT
RESPONSE REGULATOR

(Francisella
tularensis) 		PF00072
(Response_reg) 		4 LEU A 108
LEU A  12
THR A  79
PRO A  55
 None
 1.06A 6ew0F-5uicA:
undetectable		 6ew0F-5uicA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uv2 (+)-LIMONENE
SYNTHASE

(Citrus sinensis) 		PF01397
(Terpene_synth)
PF03936
(Terpene_synth_C) 		4 LEU A 385
LEU A 449
THR A 340
ARG A 329
 None
None
LA6  A 704 (-3.4A)
None
 0.95A 6ew0F-5uv2A:
undetectable		 6ew0F-5uv2A:
8.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5veo ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 5

(Mus musculus) 		PF01663
(Phosphodiest) 		4 LEU A 215
LEU A  43
THR A 236
ARG A 360
 None
 1.01A 6ew0F-5veoA:
undetectable		 6ew0F-5veoA:
9.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vf4 UNCHARACTERIZED
PROTEIN

(Thermus
aquaticus) 		PF03781
(FGE-sulfatase) 		4 LEU A 333
LEU A 207
THR A 276
ARG A 238
 None
 1.00A 6ew0F-5vf4A:
undetectable		 6ew0F-5vf4A:
13.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vky TOPOISOMERASE I
DAMAGE AFFECTED
PROTEIN 2

(Saccharomyces
cerevisiae) 		PF03645
(Tctex-1) 		4 LEU A  50
LEU A  55
THR A 120
PRO A  16
 None
 1.07A 6ew0F-5vkyA:
undetectable		 6ew0F-5vkyA:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xdr PRE-MRNA-SPLICING
FACTOR ATP-DEPENDENT
RNA HELICASE DHX15

(Homo sapiens) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF04408
(HA2)
PF07717
(OB_NTP_bind) 		4 LEU A 594
LEU A 693
THR A 626
PRO A 731
 None
 0.77A 6ew0F-5xdrA:
undetectable		 6ew0F-5xdrA:
6.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xyi 40S RIBOSOMAL
PROTEIN S21
UNCHARACTERIZED
PROTEIN

(Trichomonas
vaginalis) 		PF00333
(Ribosomal_S5)
PF01249
(Ribosomal_S21e)
PF03719
(Ribosomal_S5_C) 		4 LEU V  23
LEU V  12
THR C 236
PRO C 166
 None
 1.07A 6ew0F-5xyiV:
undetectable		 6ew0F-5xyiV:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ydf PARAFIBROMIN

(Homo sapiens) 		no annotation 4 LEU A   8
LEU A  94
THR A  56
ARG A  77
 None
 0.82A 6ew0F-5ydfA:
undetectable		 6ew0F-5ydfA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ba5 VARIABLE DOMAIN OF
LIGHT CHAIN,
ANTIBODY R11

(Homo sapiens) 		no annotation 4 LEU A  55
LEU A  74
THR A  46
ARG A  81
 None
 0.96A 6ew0F-6ba5A:
undetectable		 6ew0F-6ba5A:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6deg BETA SLIDING CLAMP

(Bartonella
birtlesii) 		no annotation 4 LEU A 313
LEU A 263
THR A 291
PRO A 370
 None
 1.11A 6ew0F-6degA:
undetectable		 6ew0F-6degA:
25.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ero DIMETHYLADENOSINE
TRANSFERASE 2,
MITOCHONDRIAL,DIMETH
YLADENOSINE
TRANSFERASE 2,
MITOCHONDRIAL

(Homo sapiens) 		no annotation 4 LEU A 259
LEU A 290
THR A 251
PRO A 181
 None
 1.04A 6ew0F-6eroA:
undetectable		 6ew0F-6eroA:
13.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fa5 PUTATIVE MRNA
SPLICING FACTOR

(Chaetomium
thermophilum) 		no annotation 4 LEU A 724
LEU A 847
THR A 742
ARG A 768
 None
 1.03A 6ew0F-6fa5A:
undetectable		 6ew0F-6fa5A:
20.93