SIMILAR PATTERNS OF AMINO ACIDS FOR 6EUQ_A_DXCA502

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h3g CYCLOMALTODEXTRINASE

(Flavobacterium
sp. 92) 		PF00128
(Alpha-amylase)
PF09087
(Cyc-maltodext_N)
PF10438
(Cyc-maltodext_C) 		5 TYR A 404
ASP A 401
MET A 443
LEU A 412
GLY A 339
 None
 1.19A 6euqA-1h3gA:
0.0		 6euqA-1h3gA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b3x IRON-RESPONSIVE
ELEMENT BINDING
PROTEIN 1

(Homo sapiens) 		PF00330
(Aconitase)
PF00694
(Aconitase_C) 		5 LEU A 491
GLY A 500
PRO A 443
GLN A 483
MET A 488
 None
 1.50A 6euqA-2b3xA:
0.0		 6euqA-2b3xA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2po4 VIRION RNA
POLYMERASE

(Escherichia
virus N4) 		no annotation 5 LEU A 332
GLN A 878
GLY A 876
GLN A 316
MET A 419
 None
 1.42A 6euqA-2po4A:
0.4		 6euqA-2po4A:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w92 ENDO-BETA-N-ACETYLGL
UCOSAMINIDASE D

(Streptococcus
pneumoniae) 		PF03644
(Glyco_hydro_85) 		5 MET A 635
LEU A 680
GLY A 596
LEU A 608
GLN A 569
 None
 1.47A 6euqA-2w92A:
undetectable		 6euqA-2w92A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yia RNA-DIRECTED RNA
POLYMERASE

(Infectious
pancreatic
necrosis virus) 		PF04197
(Birna_RdRp) 		5 GLN A 469
GLY A 472
PRO A 338
LEU A 422
MET A 415
 None
 1.49A 6euqA-2yiaA:
0.0		 6euqA-2yiaA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zvi 2,3-DIKETO-5-METHYLT
HIOPENTYL-1-PHOSPHAT
E ENOLASE

(Bacillus
subtilis) 		PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N) 		5 ASP A 112
LEU A  94
GLN A 252
GLY A 125
LEU A  13
 None
 1.18A 6euqA-2zviA:
0.0		 6euqA-2zviA:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zvi 2,3-DIKETO-5-METHYLT
HIOPENTYL-1-PHOSPHAT
E ENOLASE

(Bacillus
subtilis) 		PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N) 		5 ASP A 112
LEU A  94
GLN A 252
GLY A 296
LEU A  13
 None
 1.21A 6euqA-2zviA:
0.0		 6euqA-2zviA:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bfj 1,3-PROPANEDIOL
OXIDOREDUCTASE

(Klebsiella
pneumoniae) 		PF00465
(Fe-ADH) 		5 ASN A 285
LEU A 288
GLN A 342
GLY A 339
LEU A 273
 FE2  A1388 (-4.3A)
None
None
None
None
 1.45A 6euqA-3bfjA:
0.0		 6euqA-3bfjA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ddm PUTATIVE MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME

(Bordetella
bronchiseptica) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 ASP A 121
LEU A 322
GLY A 369
PRO A  89
LEU A 292
 None
 1.34A 6euqA-3ddmA:
undetectable		 6euqA-3ddmA:
24.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3djl PROTEIN AIDB

(Escherichia
coli) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M) 		5 ASN A  17
GLY A 537
PRO A  14
LEU A  56
GLN A 126
 None
 1.14A 6euqA-3djlA:
2.0		 6euqA-3djlA:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eqn GLUCAN
1,3-BETA-GLUCOSIDASE

(Phanerochaete
chrysosporium) 		PF12708
(Pectate_lyase_3) 		5 ASN A 148
ASP A 133
GLY A 581
PRO A 134
GLN A  83
 None
 1.23A 6euqA-3eqnA:
undetectable		 6euqA-3eqnA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h7k AGMATINE DEIMINASE

(Arabidopsis
thaliana) 		PF04371
(PAD_porph) 		5 ASN A 187
MET A 159
LEU A 161
GLY A 214
LEU A 199
 None
 1.31A 6euqA-3h7kA:
0.0		 6euqA-3h7kA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ig3 PLXNA3 PROTEIN

(Mus musculus) 		PF08337
(Plexin_cytopl) 		5 ASN A1395
LEU A1391
GLN A1386
PRO A1402
LEU A1406
 None
 1.48A 6euqA-3ig3A:
undetectable		 6euqA-3ig3A:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nra ASPARTATE
AMINOTRANSFERASE

(Rhodobacter
sphaeroides) 		PF00155
(Aminotran_1_2) 		5 LEU A 104
GLN A 278
GLY A 112
LEU A  86
GLN A 290
 None
 1.45A 6euqA-3nraA:
undetectable		 6euqA-3nraA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u5z DNA POLYMERASE
ACCESSORY PROTEIN 44

(Escherichia
virus T4) 		PF00004
(AAA) 		5 TYR B 257
LEU B 242
GLY B 233
PRO B 255
LEU B 250
 None
 1.33A 6euqA-3u5zB:
undetectable		 6euqA-3u5zB:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ut3 PLASMINOGEN
ACTIVATOR INHIBITOR
1

(Homo sapiens) 		PF00079
(Serpin) 		5 MET A 295
LEU A 290
GLY A 153
LEU A  43
GLN A 322
 None
 1.43A 6euqA-3ut3A:
undetectable		 6euqA-3ut3A:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c90 ALPHA-GLUCURONIDASE
GH115

(Bacteroides
ovatus) 		PF15979
(Glyco_hydro_115) 		5 MET A 582
LEU A 585
LEU A 530
GLN A 592
MET A 588
 None
 1.45A 6euqA-4c90A:
1.5		 6euqA-4c90A:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kc8 GLYCOSIDE HYDROLASE,
FAMILY 43

(Thermotoga
petrophila) 		PF04616
(Glyco_hydro_43)
PF16369
(GH43_C) 		5 ASN A 315
LEU A 348
GLY A 364
PRO A 312
LEU A 290
 None
 1.29A 6euqA-4kc8A:
undetectable		 6euqA-4kc8A:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n4u PUTATIVE ABC
TRANSPORTER
PERIPLASMIC
SOLUTE-BINDING
PROTEIN

(Bordetella
bronchiseptica) 		PF03480
(DctP) 		5 LEU A 156
GLN A 162
GLY A 201
PRO A 105
LEU A 297
 None
 1.41A 6euqA-4n4uA:
undetectable		 6euqA-4n4uA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ru0 PUTATIVE
BRANCHED-CHAIN AMINO
ACID ABC
TRANSPORTER,
PERIPLASMIC
BRANCHED-CHAIN AMINO
ACID-BINDING PROTEIN

(Pseudomonas
protegens) 		PF13458
(Peripla_BP_6) 		5 ASN A 330
MET A  54
GLY A 358
PRO A 108
GLN A  31
 None
 1.49A 6euqA-4ru0A:
undetectable		 6euqA-4ru0A:
23.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uri CHITINASE-RELATED
AGGLUTININ

(Robinia
pseudoacacia) 		PF00704
(Glyco_hydro_18) 		5 ASP A 294
LEU A 231
GLY A 336
LEU A 203
GLN A 308
 None
 1.21A 6euqA-4uriA:
undetectable		 6euqA-4uriA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xb0 SERINE/THREONINE-PRO
TEIN KINASE PLK2

(Homo sapiens) 		PF00659
(POLO_box) 		5 MET A 673
LEU A 669
PRO A 487
LEU A 660
GLN A 496
 None
 1.35A 6euqA-4xb0A:
undetectable		 6euqA-4xb0A:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yuf CORB

(Corallococcus
coralloides) 		PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III) 		5 TYR A 335
MET A 331
LEU A 319
GLY A 309
LEU A 128
 None
 1.11A 6euqA-4yufA:
undetectable		 6euqA-4yufA:
20.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4zow MULTIDRUG
TRANSPORTER MDFA

(Escherichia
coli) 		PF07690
(MFS_1) 		11 TYR A  30
ASN A  33
ASP A  34
MET A  58
LEU A  62
GLN A  69
GLY A 123
PRO A 154
LEU A 236
GLN A 357
MET A 358
 CLM  A 500 (-4.2A)
CLM  A 500 (-3.5A)
CLM  A 500 (-2.7A)
CLM  A 500 (-4.7A)
None
None
None
CLM  A 500 ( 4.4A)
CLM  A 500 (-4.9A)
None
None
 0.56A 6euqA-4zowA:
67.8		 6euqA-4zowA:
99.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f4z EPOXIDE HYDROLASE

(Streptomyces
carzinostaticus) 		PF06441
(EHN) 		5 LEU A 182
GLY A  98
PRO A 340
LEU A 328
GLN A 172
 None
 1.45A 6euqA-5f4zA:
undetectable		 6euqA-5f4zA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hee PUTATIVE
UNCHARACTERIZED
PROTEIN, TK2203
PROTEIN

(Thermococcus
kodakarensis) 		PF02900
(LigB) 		5 ASN A  49
LEU A 117
GLY A  72
PRO A  47
GLN A 126
 None
 1.42A 6euqA-5heeA:
undetectable		 6euqA-5heeA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j5d 4-HYDROXY-TETRAHYDRO
DIPICOLINATE
SYNTHASE

(Mycobacterium
tuberculosis) 		PF00701
(DHDPS) 		5 ASN A 199
ASP A 196
LEU A 203
GLY A 169
LEU A 226
 None
 1.37A 6euqA-5j5dA:
undetectable		 6euqA-5j5dA:
25.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kar ACID
SPHINGOMYELINASE-LIK
E PHOSPHODIESTERASE
3B

(Mus musculus) 		PF00149
(Metallophos) 		5 ASP A 209
LEU A 192
GLY A 240
LEU A 217
GLN A 273
 None
 1.10A 6euqA-5karA:
undetectable		 6euqA-5karA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kyu PROTEIN TRANSPORT
PROTEIN SEC24D

(Homo sapiens) 		PF00626
(Gelsolin)
PF04810
(zf-Sec23_Sec24)
PF04811
(Sec23_trunk)
PF04815
(Sec23_helical)
PF08033
(Sec23_BS) 		5 MET B 847
LEU B 850
GLY B 707
PRO B 333
LEU B 810
 None
 1.43A 6euqA-5kyuB:
undetectable		 6euqA-5kyuB:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v3e TRANSCRIPTIONAL
REGULATOR

(Porphyromonas
gingivalis) 		no annotation 5 LEU A 102
GLN A  74
GLY A  69
PRO A  88
LEU A  80
 None
 1.27A 6euqA-5v3eA:
undetectable		 6euqA-5v3eA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5veh KYNURENINE
AMINOTRANSFERASE

(Aedes aegypti) 		no annotation 5 MET A 337
LEU A 332
GLY A  45
LEU A 422
MET A 328
 None
 1.38A 6euqA-5vehA:
undetectable		 6euqA-5vehA:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zji CHLOROPHYLL A-B
BINDING PROTEIN,
CHLOROPLASTIC

(Zea mays) 		no annotation 5 TYR 3 194
ASP 3 191
LEU 3  64
GLY 3 223
PRO 3 192
 CLA  3 610 (-4.3A)
None
CLA  3 602 ( 4.8A)
None
None
 1.45A 6euqA-5zji3:
undetectable		 6euqA-5zji3:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bcq TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY M
MEMBER 4

(Mus musculus) 		no annotation 5 MET B 431
LEU B 434
GLY B 582
PRO B 458
LEU B 464
 None
 1.47A 6euqA-6bcqB:
3.3		 6euqA-6bcqB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f5o POLYMERASE ACIDIC
PROTEIN
RNA-DIRECTED RNA
POLYMERASE CATALYTIC
SUBUNIT

(Influenza B
virus;
Influenza B
virus) 		no annotation
no annotation 		5 LEU B 373
GLN B 367
GLY B  33
LEU B 389
GLN A 388
 None
A  V   8 ( 4.0A)
A  V   8 ( 3.5A)
None
A  V   7 ( 4.8A)
 1.32A 6euqA-6f5oB:
undetectable		 6euqA-6f5oB:
undetectable