SIMILAR PATTERNS OF AMINO ACIDS FOR 6EU9_B_REAB601_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dc1 BSOBI RESTRICTION
ENDONUCLEASE

(Geobacillus
stearothermophilus) 		PF09194
(Endonuc-BsobI) 		5 VAL A 204
LEU A 206
LEU A 261
GLY A 239
VAL A 211
 None
 1.13A 6eu9B-1dc1A:
1.7		 6eu9B-1dc1A:
13.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1heh ENDO-1,4-BETA-XYLANA
SE D

(Cellulomonas
fimi) 		no annotation 5 VAL C 626
SER C 601
PHE C 624
GLY C 638
GLY C 608
 None
 1.14A 6eu9B-1hehC:
undetectable		 6eu9B-1hehC:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lpe APOLIPOPROTEIN E3

(Homo sapiens) 		PF01442
(Apolipoprotein) 		5 LEU A 155
LEU A  93
GLY A  23
GLY A 165
VAL A 161
 None
 1.21A 6eu9B-1lpeA:
undetectable		 6eu9B-1lpeA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ltd FLAVOCYTOCHROME B2

(Saccharomyces
cerevisiae) 		PF00173
(Cyt-b5)
PF01070
(FMN_dh) 		5 VAL A 369
LEU A 370
SER A 371
GLY A 428
GLY A 432
 None
None
FMN  A 570 (-3.5A)
None
FMN  A 570 (-3.8A)
 1.13A 6eu9B-1ltdA:
0.0		 6eu9B-1ltdA:
9.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1npm NEUROPSIN

(Mus musculus) 		PF00089
(Trypsin) 		5 ARG A  66
VAL A  65
GLY A  69
GLY A  48
VAL A  52
 None
 1.08A 6eu9B-1npmA:
undetectable		 6eu9B-1npmA:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ovl ORPHAN NUCLEAR
RECEPTOR NURR1 (MSE
496, 511)

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 LEU B 409
LEU B 444
PHE B 464
GLY B 569
ARG B 572
 None
 1.02A 6eu9B-1ovlB:
24.0		 6eu9B-1ovlB:
16.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qcw FLAVOCYTOCHROME B2

(Saccharomyces
cerevisiae) 		PF01070
(FMN_dh) 		5 VAL A 369
LEU A 370
SER A 371
GLY A 428
GLY A 432
 None
None
FNS  A 570 (-3.6A)
None
FNS  A 570 (-3.4A)
 1.14A 6eu9B-1qcwA:
0.0		 6eu9B-1qcwA:
11.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qmh RNA 3'-TERMINAL
PHOSPHATE CYCLASE

(Escherichia
coli) 		PF01137
(RTC)
PF05189
(RTC_insert) 		5 VAL A  67
LEU A  78
LEU A  20
GLY A  64
VAL A  56
 None
 1.12A 6eu9B-1qmhA:
0.0		 6eu9B-1qmhA:
13.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uls PUTATIVE
3-OXOACYL-ACYL
CARRIER PROTEIN
REDUCTASE

(Thermus
thermophilus) 		PF13561
(adh_short_C2) 		5 ARG A 137
PHE A 233
GLY A 141
GLY A 157
VAL A 155
 None
 1.19A 6eu9B-1ulsA:
0.0		 6eu9B-1ulsA:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uou THYMIDINE
PHOSPHORYLASE

(Homo sapiens) 		PF00591
(Glycos_transf_3)
PF02885
(Glycos_trans_3N)
PF07831
(PYNP_C) 		5 LEU A 395
LEU A 423
GLY A 119
GLY A 278
VAL A 281
 None
None
CMU  A1481 ( 3.8A)
None
None
 1.21A 6eu9B-1uouA:
0.0		 6eu9B-1uouA:
8.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1usy ATP
PHOSPHORIBOSYLTRANSF
ERASE REGULATORY
SUBUNIT

(Thermotoga
maritima) 		PF13393
(tRNA-synt_His) 		5 VAL C 109
LEU C 110
SER C 106
PHE C 239
GLY C  94
 None
 1.20A 6eu9B-1usyC:
0.0		 6eu9B-1usyC:
14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vme FLAVOPROTEIN

(Thermotoga
maritima) 		PF00258
(Flavodoxin_1) 		5 VAL A 246
LEU A 239
GLY A 203
GLY A 170
VAL A 194
 None
 1.09A 6eu9B-1vmeA:
0.0		 6eu9B-1vmeA:
13.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vme FLAVOPROTEIN

(Thermotoga
maritima) 		PF00258
(Flavodoxin_1) 		5 VAL A 246
LEU A 239
GLY A 203
GLY A 171
VAL A 194
 None
 0.99A 6eu9B-1vmeA:
0.0		 6eu9B-1vmeA:
13.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xkg MAJOR MITE FECAL
ALLERGEN DER P 1

(Dermatophagoides
pteronyssinus) 		PF00112
(Peptidase_C1) 		5 VAL A 102
LEU A 128
SER A 125
LEU A 211
GLY A 256
 None
 1.17A 6eu9B-1xkgA:
undetectable		 6eu9B-1xkgA:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zb1 BRO1 PROTEIN

(Saccharomyces
cerevisiae) 		PF03097
(BRO1) 		5 VAL A 167
LEU A 169
SER A 166
PHE A 122
GLY A 235
 None
 1.21A 6eu9B-1zb1A:
undetectable		 6eu9B-1zb1A:
15.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zl0 HYPOTHETICAL PROTEIN
PA5198

(Pseudomonas
aeruginosa) 		PF02016
(Peptidase_S66) 		5 LEU A 230
SER A 229
PHE A 266
GLY A 248
GLY A 220
 None
GOL  A1402 (-2.6A)
None
None
None
 1.21A 6eu9B-1zl0A:
undetectable		 6eu9B-1zl0A:
13.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ap1 PUTATIVE REGULATOR
PROTEIN

(Salmonella
enterica) 		PF00480
(ROK) 		5 LEU A  40
LEU A  14
PHE A  39
GLY A   4
VAL A  60
 None
 1.21A 6eu9B-2ap1A:
undetectable		 6eu9B-2ap1A:
11.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d1f THREONINE SYNTHASE

(Mycobacterium
tuberculosis) 		PF00291
(PALP) 		5 VAL A 235
LEU A 234
LEU A 224
GLY A 230
GLY A 305
 None
 0.97A 6eu9B-2d1fA:
undetectable		 6eu9B-2d1fA:
12.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d2e SUFC PROTEIN

(Thermus
thermophilus) 		PF00005
(ABC_tran) 		5 VAL A 198
LEU A 197
LEU A 157
GLY A 185
VAL A 182
 None
 1.01A 6eu9B-2d2eA:
undetectable		 6eu9B-2d2eA:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ehh DIHYDRODIPICOLINATE
SYNTHASE

(Aquifex
aeolicus) 		PF00701
(DHDPS) 		5 LEU A 192
PHE A 226
GLY A 198
GLY A   4
VAL A 202
 None
 1.04A 6eu9B-2ehhA:
undetectable		 6eu9B-2ehhA:
13.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hq1 GLUCOSE/RIBITOL
DEHYDROGENASE

(Ruminiclostridium
thermocellum) 		PF13561
(adh_short_C2) 		5 VAL A  88
LEU A  87
LEU A   3
GLY A  12
GLY A  26
 None
 1.21A 6eu9B-2hq1A:
undetectable		 6eu9B-2hq1A:
16.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2inv INSULIN
FRUCTOTRANSFERASE

(Bacillus sp.
snu-7) 		no annotation 5 ARG A 294
LEU A 353
GLY A 268
GLY A 348
ARG A 349
 None
 1.17A 6eu9B-2invA:
undetectable		 6eu9B-2invA:
10.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j7n RNA-DEPENDENT RNA
POLYMERASE

(Neurospora
crassa) 		PF05183
(RdRP) 		5 VAL A 493
LEU A 494
SER A 495
LEU A 539
GLY A 523
 None
 1.09A 6eu9B-2j7nA:
undetectable		 6eu9B-2j7nA:
5.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oqr SENSORY TRANSDUCTION
PROTEIN REGX3

(Mycobacterium
tuberculosis) 		PF00072
(Response_reg)
PF00486
(Trans_reg_C) 		5 VAL A  49
LEU A  50
LEU A  55
GLY A  45
GLY A  34
 None
 1.18A 6eu9B-2oqrA:
undetectable		 6eu9B-2oqrA:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q1f CHONDROITINASE

(Bacteroides
thetaiotaomicron) 		PF02278
(Lyase_8)
PF09092
(Lyase_N)
PF09093
(Lyase_catalyt) 		5 VAL A 676
SER A 678
LEU A 686
GLY A 619
GLY A 637
 None
 0.89A 6eu9B-2q1fA:
undetectable		 6eu9B-2q1fA:
6.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w38 SIALIDASE

(Pseudomonas
aeruginosa) 		PF13088
(BNR_2) 		5 LEU A  30
LEU A  11
GLY A  82
GLY A 310
VAL A 301
 None
 1.19A 6eu9B-2w38A:
undetectable		 6eu9B-2w38A:
11.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xkr PUTATIVE CYTOCHROME
P450 142

(Mycobacterium
tuberculosis) 		PF00067
(p450) 		5 VAL A 160
LEU A 163
SER A 164
GLY A 231
GLY A 383
 None
PG4  A1399 (-4.8A)
None
HEM  A1400 (-3.2A)
None
 0.78A 6eu9B-2xkrA:
2.0		 6eu9B-2xkrA:
9.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xkr PUTATIVE CYTOCHROME
P450 142

(Mycobacterium
tuberculosis) 		PF00067
(p450) 		5 VAL A 160
LEU A 163
SER A 164
GLY A 383
ARG A 236
 None
PG4  A1399 (-4.8A)
None
None
None
 0.90A 6eu9B-2xkrA:
2.0		 6eu9B-2xkrA:
9.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ybq METHYLTRANSFERASE

(Pseudomonas
aeruginosa) 		PF00590
(TP_methylase) 		5 VAL A 212
LEU A 244
GLY A 143
GLY A 225
ARG A 224
 None
SAH  A1267 (-3.9A)
None
None
None
 1.21A 6eu9B-2ybqA:
undetectable		 6eu9B-2ybqA:
14.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yxg DIHYDRODIPICOLINATE
SYNTHASE

(Methanocaldococcus
jannaschii) 		PF00701
(DHDPS) 		5 LEU A 190
PHE A 224
GLY A 196
GLY A   4
VAL A 200
 None
 1.12A 6eu9B-2yxgA:
undetectable		 6eu9B-2yxgA:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zu0 PROTEIN SUFD

(Escherichia
coli) 		PF01458
(UPF0051) 		5 VAL A 277
SER A 306
GLY A 249
GLY A 415
ARG A 413
 None
 1.17A 6eu9B-2zu0A:
undetectable		 6eu9B-2zu0A:
13.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ayx MEMBRANE-BOUND
HYDROGENASE LARGE
SUBUNIT

(Hydrogenovibrio
marinus) 		PF00374
(NiFeSe_Hases) 		5 VAL A 408
LEU A 297
LEU A 418
GLY A 405
GLY A 323
 None
 1.10A 6eu9B-3ayxA:
undetectable		 6eu9B-3ayxA:
8.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c6c 3-KETO-5-AMINOHEXANO
ATE CLEAVAGE ENZYME

(Cupriavidus
pinatubonensis) 		PF05853
(BKACE) 		5 ARG A 246
VAL A 245
LEU A   7
LEU A 277
GLY A 226
 NI  A 298 ( 4.1A)
None
None
None
None
 1.16A 6eu9B-3c6cA:
undetectable		 6eu9B-3c6cA:
15.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmv PROTEIN RECA

(Escherichia
coli) 		PF00154
(RecA) 		5 LEU A2045
SER A2044
LEU A2075
GLY A2052
VAL A2244
 None
 1.20A 6eu9B-3cmvA:
undetectable		 6eu9B-3cmvA:
4.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cr8 SULFATE
ADENYLYLTRANSFERASE,
ADENYLYLSULFATE
KINASE

(Thiobacillus
denitrificans) 		PF01583
(APS_kinase)
PF01747
(ATP-sulfurylase)
PF14306
(PUA_2) 		5 ARG A  96
LEU A  35
LEU A  48
GLY A  58
VAL A 133
 None
 1.19A 6eu9B-3cr8A:
undetectable		 6eu9B-3cr8A:
10.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dpi NAD+ SYNTHETASE

(Burkholderia
pseudomallei) 		PF02540
(NAD_synthase) 		5 ARG A 199
VAL A 200
LEU A  50
GLY A 194
GLY A 167
 None
 1.23A 6eu9B-3dpiA:
undetectable		 6eu9B-3dpiA:
15.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3drx BTB/POZ
DOMAIN-CONTAINING
PROTEIN KCTD5

(Homo sapiens) 		PF02214
(BTB_2) 		5 VAL A 102
LEU A 103
LEU A 117
PHE A  55
VAL A 122
 None
 1.23A 6eu9B-3drxA:
undetectable		 6eu9B-3drxA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fcp L-ALA-D/L-GLU
EPIMERASE, A
MUCONATE LACTONIZING
ENZYME

(Klebsiella
pneumoniae) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 ARG A 197
VAL A 198
LEU A 169
LEU A 176
GLY A 212
 None
 1.07A 6eu9B-3fcpA:
undetectable		 6eu9B-3fcpA:
12.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g6l CHITINASE

(Clonostachys
rosea) 		PF00704
(Glyco_hydro_18) 		5 LEU A 291
SER A 378
LEU A 398
GLY A 372
GLY A 402
 None
 1.21A 6eu9B-3g6lA:
undetectable		 6eu9B-3g6lA:
12.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gaz ALCOHOL
DEHYDROGENASE
SUPERFAMILY PROTEIN

(Novosphingobium
aromaticivorans) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 VAL A 111
LEU A 115
GLY A 103
GLY A  73
VAL A  37
 None
 1.11A 6eu9B-3gazA:
undetectable		 6eu9B-3gazA:
12.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hug PROBABLE CONSERVED
MEMBRANE PROTEIN
RNA POLYMERASE SIGMA
FACTOR

(Mycobacterium
tuberculosis) 		PF04545
(Sigma70_r4)
PF13490
(zf-HC2) 		5 VAL B  67
LEU B  70
LEU A 123
ARG A 164
VAL A 163
 None
 1.19A 6eu9B-3hugB:
undetectable		 6eu9B-3hugB:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lxu TRIPEPTIDYL-PEPTIDAS
E 2

(Drosophila
melanogaster) 		PF00082
(Peptidase_S8)
PF12580
(TPPII)
PF12583
(TPPII_N) 		5 VAL X 382
SER X 424
GLY X 431
GLY X 511
VAL X 435
 None
 1.18A 6eu9B-3lxuX:
undetectable		 6eu9B-3lxuX:
5.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nvn PLEXIN-C1

(Homo sapiens) 		PF01437
(PSI) 		5 ARG B 291
VAL B 309
LEU B 295
SER B 296
LEU B 429
 None
 1.16A 6eu9B-3nvnB:
undetectable		 6eu9B-3nvnB:
9.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nxl GLUCARATE
DEHYDRATASE

(Burkholderia
lata) 		PF13378
(MR_MLE_C) 		5 VAL A 230
LEU A  32
SER A 463
LEU A 451
GLY A 175
 None
 1.20A 6eu9B-3nxlA:
undetectable		 6eu9B-3nxlA:
11.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o3p MANNOSYL-3-PHOSPHOGL
YCERATE SYNTHASE

(Rubrobacter
xylanophilus) 		PF00535
(Glycos_transf_2) 		5 VAL A  79
LEU A  48
SER A  50
GLY A  96
GLY A  87
 None
 1.06A 6eu9B-3o3pA:
undetectable		 6eu9B-3o3pA:
12.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3on4 TRANSCRIPTIONAL
REGULATOR, TETR
FAMILY

(Legionella
pneumophila) 		PF00440
(TetR_N) 		5 LEU A  95
LEU A 176
GLY A 106
GLY A 163
VAL A 160
 None
 1.16A 6eu9B-3on4A:
undetectable		 6eu9B-3on4A:
16.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pnn CONSERVED DOMAIN
PROTEIN

(Porphyromonas
gingivalis) 		no annotation 5 VAL A  51
LEU A  76
LEU A   5
PHE A  60
GLY A  11
 None
None
None
None
GOL  A 302 (-3.6A)
 1.21A 6eu9B-3pnnA:
undetectable		 6eu9B-3pnnA:
15.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qld MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN

(Alicyclobacillus
acidocaldarius) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 VAL A 127
LEU A 130
PHE A 276
GLY A 354
VAL A 349
 None
 0.97A 6eu9B-3qldA:
undetectable		 6eu9B-3qldA:
10.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r75 ANTHRANILATE/PARA-AM
INOBENZOATE
SYNTHASES COMPONENT
I

(Burkholderia
lata) 		PF00117
(GATase)
PF00425
(Chorismate_bind) 		5 ARG A 352
VAL A 387
LEU A 390
SER A 391
GLY A 367
 PYR  A 702 ( 3.9A)
None
None
None
PYR  A 702 (-3.9A)
 1.21A 6eu9B-3r75A:
undetectable		 6eu9B-3r75A:
8.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u62 SHIKIMATE
DEHYDROGENASE

(Thermotoga
maritima) 		PF01488
(Shikimate_DH)
PF08501
(Shikimate_dh_N) 		5 ARG A  65
VAL A  66
GLY A   7
GLY A  55
VAL A  85
 None
 1.11A 6eu9B-3u62A:
undetectable		 6eu9B-3u62A:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u7v BETA-GALACTOSIDASE

(Caulobacter
vibrioides) 		PF02449
(Glyco_hydro_42) 		5 VAL A 474
LEU A 483
LEU A 546
GLY A 486
VAL A 441
 None
 1.20A 6eu9B-3u7vA:
undetectable		 6eu9B-3u7vA:
9.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uw2 PHOSPHOGLUCOMUTASE/P
HOSPHOMANNOMUTASE
FAMILY PROTEIN

(Burkholderia
thailandensis) 		PF00408
(PGM_PMM_IV)
PF02878
(PGM_PMM_I)
PF02879
(PGM_PMM_II)
PF02880
(PGM_PMM_III) 		5 LEU A  52
SER A  53
LEU A  20
GLY A 244
VAL A 106
 None
 1.02A 6eu9B-3uw2A:
undetectable		 6eu9B-3uw2A:
12.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v9e LACCASE

(Botrytis aclada) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 VAL A  75
LEU A  35
PHE A  54
GLY A 101
GLY A  83
 None
 1.20A 6eu9B-3v9eA:
undetectable		 6eu9B-3v9eA:
11.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vpj TSE1-SPECIFIC
IMMUNITY PROTEIN

(Pseudomonas
aeruginosa) 		no annotation 5 ARG E 100
LEU E 102
GLY E  98
GLY E  41
VAL E  48
 None
 1.03A 6eu9B-3vpjE:
undetectable		 6eu9B-3vpjE:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vpj TSE1-SPECIFIC
IMMUNITY PROTEIN

(Pseudomonas
aeruginosa) 		no annotation 5 ARG E 100
VAL E 101
LEU E 102
GLY E  41
VAL E  48
 None
 1.07A 6eu9B-3vpjE:
undetectable		 6eu9B-3vpjE:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vw5 CELLOBIOSE
2-EPIMERASE

(Ruminococcus
albus) 		PF07221
(GlcNAc_2-epim) 		5 VAL A  47
LEU A  49
LEU A 119
GLY A 100
VAL A  92
 None
 1.19A 6eu9B-3vw5A:
undetectable		 6eu9B-3vw5A:
12.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vw5 CELLOBIOSE
2-EPIMERASE

(Ruminococcus
albus) 		PF07221
(GlcNAc_2-epim) 		5 VAL A  47
SER A  51
LEU A 119
GLY A 100
VAL A  92
 None
 1.11A 6eu9B-3vw5A:
undetectable		 6eu9B-3vw5A:
12.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a7p UDP-GLUCOSE
DEHYDROGENASE

(Sphingomonas
elodea) 		PF00984
(UDPG_MGDP_dh)
PF03720
(UDPG_MGDP_dh_C)
PF03721
(UDPG_MGDP_dh_N) 		5 ARG A 154
PHE A 324
GLY A 156
GLY A   9
VAL A  11
 None
None
None
NAD  A 501 (-3.2A)
NAD  A 501 (-4.2A)
 1.22A 6eu9B-4a7pA:
undetectable		 6eu9B-4a7pA:
10.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dbg RING FINGER PROTEIN
31

(Homo sapiens) 		PF16678
(HOIP-UBA) 		5 ARG B 577
VAL B 580
LEU B 612
GLY B 545
GLY B 593
 None
 1.15A 6eu9B-4dbgB:
undetectable		 6eu9B-4dbgB:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dwd MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME,
C-TERMINAL DOMAIN
PROTEIN

(Paracoccus
denitrificans) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 VAL A 312
LEU A 316
PHE A 295
GLY A 280
GLY A 305
 None
 1.18A 6eu9B-4dwdA:
undetectable		 6eu9B-4dwdA:
11.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e3e MAOC DOMAIN PROTEIN
DEHYDRATASE

(Chloroflexus
aurantiacus) 		PF01575
(MaoC_dehydratas) 		5 VAL A  34
LEU A  68
LEU A  47
GLY A 103
ARG A  61
 None
 1.11A 6eu9B-4e3eA:
undetectable		 6eu9B-4e3eA:
11.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ehc PE-PGRS FAMILY
PROTEIN

(Mycobacterium
tuberculosis) 		no annotation 5 LEU A 107
SER A 108
PHE A 106
GLY A 192
GLY A -10
 EDO  A 327 ( 4.7A)
None
EDO  A 327 (-3.3A)
ZN  A 301 ( 4.9A)
EDO  A 315 (-4.4A)
 1.19A 6eu9B-4ehcA:
undetectable		 6eu9B-4ehcA:
13.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fff LEVAN
FRUCTOTRANSFERASE

(Paenarthrobacter
ureafaciens) 		PF00251
(Glyco_hydro_32N)
PF08244
(Glyco_hydro_32C) 		5 VAL A 474
LEU A 432
GLY A 414
GLY A 426
VAL A 434
 None
 0.98A 6eu9B-4fffA:
undetectable		 6eu9B-4fffA:
12.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fgi TSI1

(Pseudomonas
aeruginosa) 		no annotation 6 ARG B 100
VAL B 101
LEU B 102
GLY B  98
GLY B  41
VAL B  48
 None
 1.13A 6eu9B-4fgiB:
undetectable		 6eu9B-4fgiB:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g2r ACCD6,
CARBOXYLTRANSFERASE
BETA-SUBUNIT OF
ACYL-COA CARBOXYLASE

(Mycobacterium
tuberculosis) 		PF01039
(Carboxyl_trans) 		5 ARG A 156
VAL A 157
LEU A 178
GLY A 133
GLY A 138
 None
H1L  A 502 (-4.9A)
None
None
H1L  A 501 (-3.4A)
 1.23A 6eu9B-4g2rA:
undetectable		 6eu9B-4g2rA:
11.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hn8 D-GLUCARATE
DEHYDRATASE

(Pseudomonas
mendocina) 		PF13378
(MR_MLE_C) 		5 VAL A 227
LEU A  30
SER A 460
LEU A 448
GLY A 172
 None
 1.19A 6eu9B-4hn8A:
undetectable		 6eu9B-4hn8A:
9.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j0k TANNASE

(Lactobacillus
plantarum) 		no annotation 5 VAL A  49
LEU A 102
GLY A 152
GLY A  56
ARG A  64
 None
 1.12A 6eu9B-4j0kA:
undetectable		 6eu9B-4j0kA:
11.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jn6 4-HYDROXY-2-OXOVALER
ATE ALDOLASE

(Mycobacterium
tuberculosis) 		PF00682
(HMGL-like)
PF07836
(DmpG_comm) 		5 ARG A  15
VAL A  47
GLY A  17
GLY A  31
VAL A  34
 OXL  A 401 (-2.7A)
None
None
None
None
 1.23A 6eu9B-4jn6A:
undetectable		 6eu9B-4jn6A:
15.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ko2 PERIPLASMIC [NIFESE]
HYDROGENASE SMALL
SUBUNIT

(Desulfomicrobium
baculatum) 		PF01058
(Oxidored_q6)
PF14720
(NiFe_hyd_SSU_C) 		5 ARG S 146
VAL S 145
LEU S 109
GLY S 130
VAL S  76
 None
 1.22A 6eu9B-4ko2S:
undetectable		 6eu9B-4ko2S:
15.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lnv THIOESTER-CONTAINING
PROTEIN I

(Anopheles
gambiae) 		PF00207
(A2M)
PF01835
(A2M_N)
PF07677
(A2M_recep)
PF07678
(A2M_comp)
PF07703
(A2M_N_2)
PF10569
(Thiol-ester_cl) 		5 VAL A 928
SER A 931
LEU A 895
GLY A 860
GLY A 898
 None
 1.23A 6eu9B-4lnvA:
undetectable		 6eu9B-4lnvA:
5.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oe7 PROBABLE
2-KETO-3-DEOXY-GALAC
TONATE ALDOLASE YAGE

(Escherichia
coli) 		PF00701
(DHDPS) 		5 VAL A 134
SER A 137
GLY A  90
GLY A 111
VAL A 142
 None
None
EDO  A 401 (-3.0A)
None
None
 1.12A 6eu9B-4oe7A:
undetectable		 6eu9B-4oe7A:
11.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oso REDUCTASE HOMOLOG

(Streptomyces
cyanogenus) 		PF13561
(adh_short_C2) 		5 VAL A  95
LEU A  94
LEU A   4
GLY A  13
GLY A  27
 None
None
None
NAP  A 301 (-3.2A)
None
 1.16A 6eu9B-4osoA:
undetectable		 6eu9B-4osoA:
14.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4paf TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT, PUTATIVE

(Ruegeria
pomeroyi) 		PF03480
(DctP) 		5 ARG A  98
VAL A  95
GLY A 138
GLY A 143
VAL A 238
 None
 1.19A 6eu9B-4pafA:
undetectable		 6eu9B-4pafA:
13.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qid BACTERIORHODOPSIN-I

(Haloquadratum
walsbyi) 		PF01036
(Bac_rhodopsin) 		5 LEU A 135
GLY A 203
GLY A  81
ARG A  82
VAL A  83
 None
 1.22A 6eu9B-4qidA:
undetectable		 6eu9B-4qidA:
12.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ur8 KETO-DEOXY-D-GALACTA
RATE DEHYDRATASE

(Agrobacterium
tumefaciens) 		PF00701
(DHDPS) 		5 LEU A  15
SER A 211
PHE A  49
GLY A 164
GLY A 168
 None
OOG  A1305 ( 3.8A)
None
None
None
 1.18A 6eu9B-4ur8A:
undetectable		 6eu9B-4ur8A:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y90 TRIOSEPHOSPHATE
ISOMERASE

(Deinococcus
radiodurans) 		PF00121
(TIM) 		5 ARG A 203
VAL A 204
LEU A 145
GLY A 201
GLY A 189
 None
 1.12A 6eu9B-4y90A:
undetectable		 6eu9B-4y90A:
16.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a7m BETA-XYLOSIDASE

(Trichoderma
reesei) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		5 ARG A 359
VAL A 358
LEU A 360
LEU A  81
VAL A  42
 None
 1.22A 6eu9B-5a7mA:
undetectable		 6eu9B-5a7mA:
8.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b69 GERANYLGERANYLGLYCER
YL PHOSPHATE
SYNTHASE

(Thermoplasma
acidophilum) 		PF01884
(PcrB) 		5 VAL A 131
LEU A 130
GLY A 101
GLY A  80
VAL A 138
 None
 1.08A 6eu9B-5b69A:
undetectable		 6eu9B-5b69A:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c04 PUTATIVE
PEROXIREDOXIN MT2298

(Mycobacterium
tuberculosis) 		PF00578
(AhpC-TSA) 		5 LEU A  90
PHE A  88
GLY A  47
GLY A 117
ARG A 116
 None
 1.20A 6eu9B-5c04A:
undetectable		 6eu9B-5c04A:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5exr DNA POLYMERASE ALPHA
SUBUNIT B

(Homo sapiens) 		PF04042
(DNA_pol_E_B)
PF08418
(Pol_alpha_B_N) 		5 VAL D 557
LEU D 538
LEU D 576
GLY D 560
VAL D 593
 None
 1.19A 6eu9B-5exrD:
undetectable		 6eu9B-5exrD:
10.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fby CLEAVED PEPTIDE
SEPARASE

(Chaetomium
thermophilum;
synthetic
construct) 		PF03568
(Peptidase_C50)
no annotation 		5 VAL A1710
LEU A1709
LEU B  16
GLY A1736
VAL A1716
 None
 0.98A 6eu9B-5fbyA:
undetectable		 6eu9B-5fbyA:
11.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fsw RNA DEPENDENT RNA
POLYMERASE QDE-1

(Thielavia
terrestris) 		PF05183
(RdRP) 		5 VAL A 122
LEU A 123
SER A 124
LEU A 166
GLY A 150
 None
 1.20A 6eu9B-5fswA:
undetectable		 6eu9B-5fswA:
7.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hm9 MAMO PROTEASE DOMAIN

(Magnetospirillum
magneticum) 		PF13365
(Trypsin_2) 		5 VAL A  67
LEU A 108
GLY A 183
GLY A  46
VAL A  82
 None
 1.13A 6eu9B-5hm9A:
undetectable		 6eu9B-5hm9A:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kdx METALLOPEPTIDASE

(Pseudomonas
aeruginosa) 		PF13402
(Peptidase_M60) 		5 ARG A 123
VAL A 124
LEU A 125
LEU A  85
GLY A 298
 None
 1.15A 6eu9B-5kdxA:
undetectable		 6eu9B-5kdxA:
6.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kju SHIKIMATE
O-HYDROXYCINNAMOYLTR
ANSFERASE

(Arabidopsis
thaliana) 		PF02458
(Transferase) 		5 VAL A 414
SER A 400
LEU A 279
GLY A 259
VAL A 261
 None
 1.13A 6eu9B-5kjuA:
undetectable		 6eu9B-5kjuA:
10.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kjv HYDROXYCINNAMOYL
TRANSFERASE

(Plectranthus
scutellarioides) 		PF02458
(Transferase) 		5 VAL A 408
SER A 394
LEU A 273
GLY A 253
VAL A 255
 None
 1.18A 6eu9B-5kjvA:
undetectable		 6eu9B-5kjvA:
11.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mh5 D-2-HYDROXYACID
DEHYDROGENASE

(Haloferax
mediterranei) 		no annotation 5 ARG A  14
VAL A  12
LEU A  25
GLY A  51
VAL A   8
 None
 1.08A 6eu9B-5mh5A:
undetectable		 6eu9B-5mh5A:
14.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n5n TUBULIN BETA CHAIN

(Homo sapiens) 		no annotation 5 VAL B 118
LEU B 119
GLY B 150
GLY B  95
VAL B  93
 None
 0.99A 6eu9B-5n5nB:
undetectable		 6eu9B-5n5nB:
11.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nd1 CAPSID PROTEIN

(Rosellinia
necatrix
quadrivirus 1) 		no annotation 5 ARG A 861
SER A  71
LEU A  66
GLY A  59
VAL A  63
 None
 1.08A 6eu9B-5nd1A:
undetectable		 6eu9B-5nd1A:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5udf LIPOPROTEIN-RELEASIN
G SYSTEM
TRANSMEMBRANE
PROTEIN LOLE

(Acinetobacter
baumannii) 		PF12704
(MacB_PCD) 		5 VAL A  99
LEU A  89
GLY A 107
GLY A 237
VAL A  83
 None
 1.08A 6eu9B-5udfA:
undetectable		 6eu9B-5udfA:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5um6 UBIQUITIN-ACTIVATING
ENZYME E1 1

(Schizosaccharomyces
pombe) 		PF00899
(ThiF)
PF09358
(E1_UFD)
PF10585
(UBA_e1_thiolCys)
PF16190
(E1_FCCH)
PF16191
(E1_4HB) 		5 ARG A 547
VAL A 545
PHE A 526
GLY A 514
GLY A 434
 None
 1.21A 6eu9B-5um6A:
undetectable		 6eu9B-5um6A:
7.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uqr 2-METHYLCITRATE
SYNTHASE,
MITOCHONDRIAL

(Aspergillus
fumigatus) 		no annotation 5 ARG A 219
LEU A 216
LEU A 297
GLY A 431
VAL A 428
 None
 1.15A 6eu9B-5uqrA:
undetectable		 6eu9B-5uqrA:
24.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wrt SOLUBLE INORGANIC
PYROPHOSPHATASE

(Toxoplasma
gondii) 		no annotation 5 VAL A 249
LEU A 252
GLY A 200
GLY A 259
VAL A 257
 None
 1.16A 6eu9B-5wrtA:
undetectable		 6eu9B-5wrtA:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xxi CYTOCHROME P450 2C9

(Homo sapiens) 		no annotation 5 LEU A 234
LEU A 201
GLY A 109
GLY A 296
VAL A 292
 None
LSN  A 501 (-4.1A)
None
LSN  A 501 (-3.5A)
LSN  A 501 (-4.9A)
 0.97A 6eu9B-5xxiA:
1.9		 6eu9B-5xxiA:
10.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ccz SERINE
HYDROXYMETHYLTRANSFE
RASE

(Medicago
truncatula) 		no annotation 5 LEU A 401
SER A 403
LEU A 235
GLY A 456
GLY A 207
 None
 1.22A 6eu9B-6cczA:
undetectable		 6eu9B-6cczA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cyz HOMOSERINE KINASE

(Mycobacteroides
abscessus) 		no annotation 5 VAL A  68
LEU A  67
LEU A  48
GLY A 112
VAL A  88
 None
ANP  A 401 ( 4.4A)
None
None
None
 1.20A 6eu9B-6cyzA:
undetectable		 6eu9B-6cyzA:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f72 MTVAO615

(Thermothelomyces
thermophila) 		no annotation 5 LEU A 366
LEU A 374
PHE A 333
GLY A 308
VAL A 383
 None
 0.92A 6eu9B-6f72A:
undetectable		 6eu9B-6f72A:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fyd PUTATIVE
FAD-DEPENDENT
OXYGENASE ENCM

(Streptomyces
maritimus) 		no annotation 5 LEU A 159
SER A 160
LEU A 117
GLY A 195
GLY A 140
 None
None
None
None
FAD  A 600 (-3.2A)
 1.09A 6eu9B-6fydA:
undetectable		 6eu9B-6fydA:
19.54