SIMILAR PATTERNS OF AMINO ACIDS FOR 6EMU_C_SAMC301_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dub 2-ENOYL-COA
HYDRATASE

(Rattus
norvegicus) 		PF00378
(ECH_1) 		5 LEU A  87
GLY A  89
ILE A  85
VAL A  47
ILE A  50
 None
 1.00A 6emuC-1dubA:
undetectable		 6emuC-1dubA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fns VON WILLEBRAND
FACTOR

(Homo sapiens) 		PF00092
(VWA) 		5 LEU A 619
THR A 594
ILE A 617
VAL A 646
ILE A 649
 None
 0.87A 6emuC-1fnsA:
1.3		 6emuC-1fnsA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1im8 YECO

(Haemophilus
influenzae) 		PF13649
(Methyltransf_25) 		5 GLY A  46
ILE A  45
ILE A 108
VAL A 110
ILE A  77
 None
 0.83A 6emuC-1im8A:
undetectable		 6emuC-1im8A:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m56 CYTOCHROME C OXIDASE

(Rhodobacter
sphaeroides) 		PF00510
(COX3) 		5 LEU C 221
ILE C 218
GLY C 216
ILE C 225
VAL C 227
 None
 0.97A 6emuC-1m56C:
undetectable		 6emuC-1m56C:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o12 N-ACETYLGLUCOSAMINE-
6-PHOSPHATE
DEACETYLASE

(Thermotoga
maritima) 		PF01979
(Amidohydro_1) 		5 ILE A 210
GLY A 211
ILE A 212
VAL A 241
VAL A 244
 None
 0.91A 6emuC-1o12A:
undetectable		 6emuC-1o12A:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pvt SUGAR-PHOSPHATE
ALDOLASE

(Thermotoga
maritima) 		PF00596
(Aldolase_II) 		5 LEU A  59
ILE A 121
ILE A  77
VAL A  70
ILE A   8
 None
 1.01A 6emuC-1pvtA:
undetectable		 6emuC-1pvtA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q50 GLUCOSE-6-PHOSPHATE
ISOMERASE

(Leishmania
mexicana) 		PF00342
(PGI) 		5 LEU A 298
GLY A 203
ILE A 204
VAL A 322
ILE A 332
 None
 0.98A 6emuC-1q50A:
1.0		 6emuC-1q50A:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t0i YLR011WP

(Saccharomyces
cerevisiae) 		PF03358
(FMN_red) 		5 ILE A   5
GLY A   4
ILE A  88
ILE A 177
VAL A 151
 None
 1.02A 6emuC-1t0iA:
2.3		 6emuC-1t0iA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t6k PHENAZINE
BIOSYNTHESIS PROTEIN
PHZF

(Pseudomonas
fluorescens) 		PF02567
(PhzC-PhzF) 		5 LEU A 134
ILE A 139
GLY A 138
ILE A 146
VAL A 156
 None
 0.91A 6emuC-1t6kA:
undetectable		 6emuC-1t6kA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u0o VON WILLEBRAND
FACTOR

(Mus musculus) 		PF00092
(VWA) 		5 LEU C 619
THR C 594
ILE C 617
VAL C 646
ILE C 649
 None
 0.91A 6emuC-1u0oC:
2.3		 6emuC-1u0oC:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uf2 CORE PROTEIN P3

(Rice dwarf
virus) 		PF09231
(RDV-p3) 		5 LEU A 397
ILE A 398
ILE A 539
ILE A 601
ILE A 360
 None
 1.08A 6emuC-1uf2A:
undetectable		 6emuC-1uf2A:
11.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w2w 5-METHYLTHIORIBOSE-1
-PHOSPHATE ISOMERASE

(Saccharomyces
cerevisiae) 		PF01008
(IF-2B) 		5 LEU A  62
ILE A  58
ILE A  56
VAL A  33
ILE A   6
 None
 0.95A 6emuC-1w2wA:
undetectable		 6emuC-1w2wA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x3l HYPOTHETICAL PROTEIN
PH0495

(Pyrococcus
horikoshii) 		PF05161
(MOFRL)
PF13660
(DUF4147) 		5 ILE A 190
GLY A 189
ILE A 185
ILE A  67
VAL A  73
 None
 1.04A 6emuC-1x3lA:
2.1		 6emuC-1x3lA:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ye8 HYPOTHETICAL UPF0334
KINASE-LIKE PROTEIN
AQ_1292

(Aquifex
aeolicus) 		PF03266
(NTPase_1) 		5 LEU A 169
THR A 161
ILE A  20
VAL A 134
ILE A 172
 None
 0.84A 6emuC-1ye8A:
2.2		 6emuC-1ye8A:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a8x DIHYDROLIPOYL
DEHYDROGENASE

(Mycobacterium
tuberculosis) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		5 ILE A 307
GLY A  14
ILE A 331
VAL A   6
ILE A 139
 None
FAD  A 480 (-4.0A)
None
None
None
 1.07A 6emuC-2a8xA:
3.4		 6emuC-2a8xA:
16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2btm PROTEIN
(TRIOSEPHOSPHATE
ISOMERASE)

(Geobacillus
stearothermophilus) 		PF00121
(TIM) 		5 LEU A  46
GLY A  86
VAL A  19
VAL A  22
ILE A  60
 None
 1.03A 6emuC-2btmA:
undetectable		 6emuC-2btmA:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c2y METHYLENETETRAHYDROF
OLATE
DEHYDROGENASE-METHEN
YLTETRAHYDROFOLATE
CYCLOHYDROLASE

(Mycobacterium
tuberculosis) 		PF00763
(THF_DHG_CYH)
PF02882
(THF_DHG_CYH_C) 		5 LEU A 216
GLY A 212
VAL A 228
VAL A 207
ILE A 164
 None
 0.97A 6emuC-2c2yA:
undetectable		 6emuC-2c2yA:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c4t 5'-FLUORO-5'-DEOXYAD
ENOSINE SYNTHASE

(Streptomyces
cattleya) 		PF01887
(SAM_adeno_trans) 		5 LEU A 225
ILE A 230
GLY A 229
ILE A 220
VAL A 195
 None
 0.94A 6emuC-2c4tA:
undetectable		 6emuC-2c4tA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fko 173AA LONG
HYPOTHETICAL
FERRIPYOCHELIN
BINDING PROTEIN

(Pyrococcus
horikoshii) 		PF00132
(Hexapep) 		5 ILE A  97
GLY A  98
ILE A  99
ILE A  64
ILE A  80
 None
 1.00A 6emuC-2fkoA:
undetectable		 6emuC-2fkoA:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h98 HTH-TYPE
TRANSCRIPTIONAL
REGULATOR CATM

(Acinetobacter
sp. ADP1) 		PF03466
(LysR_substrate) 		5 LEU A 142
ILE A  94
GLY A  95
THR A 128
VAL A 289
 None
None
None
CL  A 315 (-4.2A)
None
 1.07A 6emuC-2h98A:
undetectable		 6emuC-2h98A:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ho9 CHEMOTAXIS PROTEIN
CHEW

(Escherichia
coli) 		PF01584
(CheW) 		5 LEU A  20
ILE A  31
GLY A  30
VAL A  87
ILE A  89
 None
 1.00A 6emuC-2ho9A:
undetectable		 6emuC-2ho9A:
24.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hti BH0577 PROTEIN

(Bacillus
halodurans) 		PF12900
(Pyridox_ox_2) 		5 ILE A  62
GLY A  59
ILE A 103
VAL A  71
ILE A  65
 None
FAD  A 200 (-3.2A)
None
None
None
 0.98A 6emuC-2htiA:
undetectable		 6emuC-2htiA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ij9 URIDYLATE KINASE

(Archaeoglobus
fulgidus) 		PF00696
(AA_kinase) 		5 LEU A   7
GLY A  40
THR A 115
THR A 116
VAL A 197
 None
SO4  A 301 (-3.4A)
None
SO4  A 301 (-3.4A)
None
 1.08A 6emuC-2ij9A:
3.7		 6emuC-2ij9A:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mpb BA42

(Bizionia
argentinensis) 		PF04536
(TPM_phosphatase) 		5 ILE A 117
GLY A 116
THR A  95
THR A  96
ILE A  31
 None
 1.05A 6emuC-2mpbA:
undetectable		 6emuC-2mpbA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o0o TNF SUPERFAMILY
LIGAND TL1A

(Homo sapiens) 		PF00229
(TNF) 		5 LEU A 195
GLY A 197
ILE A 212
ILE A 149
ILE A 181
 None
 0.98A 6emuC-2o0oA:
undetectable		 6emuC-2o0oA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q2h SECRETION CHAPERONE,
PHAGE-DISPLAY
DERIVED PEPTIDE

(Agrobacterium
fabrum) 		PF01588
(tRNA_bind) 		5 LEU A  62
ILE A  20
GLY A  64
ILE A  53
VAL A  98
 None
 1.08A 6emuC-2q2hA:
undetectable		 6emuC-2q2hA:
24.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q2v BETA-D-HYDROXYBUTYRA
TE DEHYDROGENASE

(Pseudomonas
putida) 		PF00106
(adh_short) 		5 LEU A 227
ILE A  17
GLY A  18
ILE A 180
ILE A 137
 None
 1.06A 6emuC-2q2vA:
3.2		 6emuC-2q2vA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q5o PHENYLPYRUVATE
DECARBOXYLASE

(Azospirillum
brasilense) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		5 ILE A 412
GLY A 411
ILE A 423
THR A 425
ASP A 448
 None
 0.80A 6emuC-2q5oA:
undetectable		 6emuC-2q5oA:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r7a BACTERIAL HEME
BINDING PROTEIN

(Shigella
dysenteriae) 		PF01497
(Peripla_BP_2) 		5 THR A  52
THR A  53
ILE A  26
VAL A  84
ILE A  37
 HEM  A 600 (-3.9A)
None
None
None
None
 0.90A 6emuC-2r7aA:
undetectable		 6emuC-2r7aA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rjo TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL
PROTEIN

(Paraburkholderia
phytofirmans) 		PF13407
(Peripla_BP_4) 		6 ILE A  86
GLY A  85
THR A  77
THR A  78
VAL A 126
ILE A 115
 None
 1.45A 6emuC-2rjoA:
4.1		 6emuC-2rjoA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wan PULLULANASE

(Bacillus
acidopullulyticus) 		PF00128
(Alpha-amylase)
PF02922
(CBM_48) 		5 LEU A 648
ILE A 676
GLY A 677
ILE A 729
VAL A 552
 None
 0.94A 6emuC-2wanA:
undetectable		 6emuC-2wanA:
11.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ycj 5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE

(Carboxydothermus
hydrogenoformans) 		PF00809
(Pterin_bind) 		5 ILE A  16
GLY A  11
ILE A  65
ASP A  44
ILE A   9
 None
None
None
C2F  A3000 ( 4.5A)
None
 0.92A 6emuC-2ycjA:
undetectable		 6emuC-2ycjA:
24.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3af5 PUTATIVE
UNCHARACTERIZED
PROTEIN PH1404

(Pyrococcus
horikoshii) 		PF07521
(RMMBL)
PF10996
(Beta-Casp)
PF16661
(Lactamase_B_6)
PF17214
(KH_7) 		5 LEU A 458
ILE A 462
GLY A 460
ILE A 456
ILE A 519
 None
 0.89A 6emuC-3af5A:
undetectable		 6emuC-3af5A:
15.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3btu GALACTOSE/LACTOSE
METABOLISM
REGULATORY PROTEIN
GAL80

(Saccharomyces
cerevisiae) 		PF01408
(GFO_IDH_MocA) 		5 LEU A 303
ILE A 170
GLY A 301
VAL A 293
ILE A 296
 None
 1.06A 6emuC-3btuA:
2.9		 6emuC-3btuA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d0c DIHYDRODIPICOLINATE
SYNTHASE

(Oceanobacillus
iheyensis) 		PF00701
(DHDPS) 		5 PRO A 137
ILE A 139
VAL A 108
VAL A  83
ASP A 106
 None
 1.02A 6emuC-3d0cA:
undetectable		 6emuC-3d0cA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dnf 4-HYDROXY-3-METHYLBU
T-2-ENYL DIPHOSPHATE
REDUCTASE

(Aquifex
aeolicus) 		PF02401
(LYTB) 		5 ILE A 142
GLY A 141
THR A 110
ILE A 179
VAL A 183
 None
 1.02A 6emuC-3dnfA:
2.4		 6emuC-3dnfA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3etc AMP-BINDING PROTEIN

(Methanosarcina
acetivorans) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		5 LEU A 228
ILE A  26
THR A 355
ILE A 267
ILE A 231
 None
GOL  A1002 (-4.2A)
None
None
None
 0.98A 6emuC-3etcA:
undetectable		 6emuC-3etcA:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fd0 PUTATIVE
CYSTATHIONINE
BETA-LYASE INVOLVED
IN ALUMINUM
RESISTANCE

(Listeria
innocua) 		PF06838
(Met_gamma_lyase) 		5 GLY A 144
ILE A 106
VAL A 151
ASP A 147
ILE A 146
 None
None
None
None
EDO  A 413 (-4.3A)
 0.84A 6emuC-3fd0A:
undetectable		 6emuC-3fd0A:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fdx PUTATIVE FILAMENT
PROTEIN / UNIVERSAL
STRESS PROTEIN F

(Klebsiella
pneumoniae) 		PF00582
(Usp) 		5 ILE A   2
ILE A  27
ILE A  17
VAL A 140
ILE A 109
 None
 1.02A 6emuC-3fdxA:
3.6		 6emuC-3fdxA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h0g DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB1
DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB2

(Schizosaccharomyces
pombe;
Schizosaccharomyces
pombe) 		PF00623
(RNA_pol_Rpb1_2)
PF04983
(RNA_pol_Rpb1_3)
PF04990
(RNA_pol_Rpb1_7)
PF04992
(RNA_pol_Rpb1_6)
PF04997
(RNA_pol_Rpb1_1)
PF04998
(RNA_pol_Rpb1_5)
PF05000
(RNA_pol_Rpb1_4)
PF00562
(RNA_pol_Rpb2_6)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF04566
(RNA_pol_Rpb2_4)
PF04567
(RNA_pol_Rpb2_5) 		5 ILE A 670
ILE A 672
ILE B1001
VAL B 814
ILE B 816
 None
 1.00A 6emuC-3h0gA:
undetectable		 6emuC-3h0gA:
9.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h0l GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A

(Aquifex
aeolicus) 		PF01425
(Amidase) 		5 GLY A 183
ILE A 182
THR A 213
ILE A 449
VAL A 391
 None
 1.07A 6emuC-3h0lA:
undetectable		 6emuC-3h0lA:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i16 ALUMINUM RESISTANCE
PROTEIN

(Clostridium
novyi) 		PF06838
(Met_gamma_lyase) 		5 ILE A 417
GLY A 416
ILE A 419
THR A 353
ILE A 336
 None
 0.84A 6emuC-3i16A:
undetectable		 6emuC-3i16A:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3icl EAL/GGDEF DOMAIN
PROTEIN

(Methylococcus
capsulatus) 		PF00990
(GGDEF) 		5 LEU A  35
ILE A 122
GLY A 123
ILE A  63
VAL A  67
 None
 0.93A 6emuC-3iclA:
undetectable		 6emuC-3iclA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ikb UNCHARACTERIZED
CONSERVED PROTEIN

(Streptococcus
mutans) 		PF03167
(UDG) 		5 LEU A 121
ILE A 191
ILE A 123
VAL A  40
ILE A  37
 None
 1.01A 6emuC-3ikbA:
undetectable		 6emuC-3ikbA:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m7n PUTATIVE
UNCHARACTERIZED
PROTEIN AF_0206

(Archaeoglobus
fulgidus) 		PF10447
(EXOSC1)
PF14382
(ECR1_N) 		5 LEU A  95
ILE A  75
GLY A  93
ILE A 108
ASP A  67
 None
 1.03A 6emuC-3m7nA:
undetectable		 6emuC-3m7nA:
23.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n2c PROLIDASE

(unidentified) 		PF01979
(Amidohydro_1) 		5 GLY A 108
THR A 159
VAL A 122
VAL A 117
ILE A 127
 None
 1.07A 6emuC-3n2cA:
2.1		 6emuC-3n2cA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oee ATP SYNTHASE SUBUNIT
ALPHA

(Saccharomyces
cerevisiae) 		PF00006
(ATP-synt_ab)
PF00306
(ATP-synt_ab_C)
PF02874
(ATP-synt_ab_N) 		5 LEU A 354
ILE A 352
VAL A 373
VAL A 159
ILE A 367
 None
 0.96A 6emuC-3oeeA:
undetectable		 6emuC-3oeeA:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rlc A1 PROTEIN

(Escherichia
virus Qbeta) 		PF16814
(Read-through) 		5 ILE A 283
GLY A 290
ILE A 319
ASP A 234
ILE A 292
 None
 1.02A 6emuC-3rlcA:
undetectable		 6emuC-3rlcA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tlm SARCOPLASMIC/ENDOPLA
SMIC RETICULUM
CALCIUM ATPASE 1

(Bos taurus) 		PF00122
(E1-E2_ATPase)
PF00689
(Cation_ATPase_C)
PF00690
(Cation_ATPase_N)
PF08282
(Hydrolase_3)
PF13246
(Cation_ATPase) 		5 GLY A 148
THR A 226
ILE A 220
VAL A 153
ILE A 150
 None
 0.93A 6emuC-3tlmA:
undetectable		 6emuC-3tlmA:
11.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tr2 OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE

(Coxiella
burnetii) 		PF00215
(OMPdecase) 		5 LEU A  34
ILE A  59
ILE A  12
ASP A  62
ILE A  36
 None
 1.05A 6emuC-3tr2A:
undetectable		 6emuC-3tr2A:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uug MULTIPLE
SUGAR-BINDING
PERIPLASMIC RECEPTOR
CHVE

(Agrobacterium
fabrum) 		PF13407
(Peripla_BP_4) 		5 LEU A 209
GLY A 240
ILE A 134
VAL A 205
ILE A 119
 None
 0.80A 6emuC-3uugA:
1.9		 6emuC-3uugA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vr5 V-TYPE SODIUM ATPASE
CATALYTIC SUBUNIT A

(Enterococcus
hirae) 		PF00006
(ATP-synt_ab)
PF02874
(ATP-synt_ab_N)
PF16886
(ATP-synt_ab_Xtn) 		5 ILE A 311
GLY A 310
ILE A 313
VAL A 251
ILE A 384
 None
 1.07A 6emuC-3vr5A:
undetectable		 6emuC-3vr5A:
14.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vta CUCUMISIN

(Cucumis melo) 		PF00082
(Peptidase_S8) 		5 PRO A 490
GLY A 306
THR A 314
THR A 315
ILE A 492
 None
DFP  A 801 ( 4.5A)
None
None
None
 0.90A 6emuC-3vtaA:
2.2		 6emuC-3vtaA:
14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aee ALPHA AMYLASE,
CATALYTIC REGION

(Staphylothermus
marinus) 		PF00128
(Alpha-amylase) 		5 ILE A 267
GLY A 266
ILE A 287
ASP A 234
ILE A 233
 None
 1.05A 6emuC-4aeeA:
undetectable		 6emuC-4aeeA:
14.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c0j MITOCHONDRIAL RHO
GTPASE

(Drosophila
melanogaster) 		PF00071
(Ras)
PF08355
(EF_assoc_1)
PF08356
(EF_assoc_2) 		5 LEU A 525
PRO A 454
ILE A 452
VAL A 506
ILE A 541
 None
 1.09A 6emuC-4c0jA:
undetectable		 6emuC-4c0jA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c8q DNA TOPOISOMERASE
2-ASSOCIATED PROTEIN
PAT1

(Saccharomyces
cerevisiae) 		PF09770
(PAT1) 		5 ILE H 533
GLY H 532
ILE H 535
ILE H 555
ILE H 591
 None
 0.97A 6emuC-4c8qH:
undetectable		 6emuC-4c8qH:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cak INTEGRIN BETA-3

(Homo sapiens) 		PF00362
(Integrin_beta)
PF07965
(Integrin_B_tail)
PF07974
(EGF_2)
PF17205
(PSI_integrin) 		5 PRO B 290
ILE B 304
THR B 230
ILE B 256
ILE B 325
 None
 1.03A 6emuC-4cakB:
undetectable		 6emuC-4cakB:
13.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cr2 26S PROTEASE
REGULATORY SUBUNIT 4
HOMOLOG

(Saccharomyces
cerevisiae) 		PF00004
(AAA) 		5 LEU I 109
GLY I 107
ILE I 106
VAL I 136
ILE I 156
 None
 0.98A 6emuC-4cr2I:
undetectable		 6emuC-4cr2I:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hv4 UDP-N-ACETYLMURAMATE
--L-ALANINE LIGASE

(Yersinia pestis) 		PF01225
(Mur_ligase)
PF02875
(Mur_ligase_C)
PF08245
(Mur_ligase_M) 		5 LEU A 405
ILE A 429
ILE A 453
ASP A 436
ILE A 438
 None
 1.06A 6emuC-4hv4A:
4.2		 6emuC-4hv4A:
17.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hw9 MECHANOSENSITIVE
CHANNEL MSCS

(Helicobacter
pylori) 		PF00924
(MS_channel) 		5 ILE A 212
GLY A 213
ILE A 214
ILE A 247
ILE A 194
 None
 0.89A 6emuC-4hw9A:
undetectable		 6emuC-4hw9A:
25.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4igg CATENIN ALPHA-1

(Homo sapiens) 		PF01044
(Vinculin) 		5 GLY A 621
ILE A 625
THR A 576
ILE A 545
ILE A 519
 None
 0.93A 6emuC-4iggA:
undetectable		 6emuC-4iggA:
13.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iql ENOYL-(ACYL-CARRIER-
PROTEIN) REDUCTASE
II

(Porphyromonas
gingivalis) 		PF03060
(NMO) 		5 PRO A  13
ILE A  15
VAL A 189
VAL A 167
ASP A 187
 None
 0.96A 6emuC-4iqlA:
undetectable		 6emuC-4iqlA:
24.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kq7 HYPOTHETICAL PROTEIN

(Bacteroides
uniformis) 		PF11175
(DUF2961) 		5 ILE A 137
GLY A 138
ILE A 190
ASP A 118
ILE A 119
 None
 0.90A 6emuC-4kq7A:
undetectable		 6emuC-4kq7A:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nre ARACHIDONATE
15-LIPOXYGENASE B

(Homo sapiens) 		PF00305
(Lipoxygenase)
PF01477
(PLAT) 		5 ILE A 435
GLY A 434
ILE A 433
THR A 431
ILE A 421
 None
None
None
C8E  A 702 ( 4.6A)
None
 0.96A 6emuC-4nreA:
undetectable		 6emuC-4nreA:
15.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o9x TCDB2, TCCC3

(Photorhabdus
luminescens) 		PF03534
(SpvB)
PF12255
(TcdB_toxin_midC)
PF12256
(TcdB_toxin_midN) 		5 LEU A1834
ILE A1820
GLY A1819
ILE A1818
VAL A2183
 None
 0.95A 6emuC-4o9xA:
undetectable		 6emuC-4o9xA:
6.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pu3 TOXIN-ANTITOXIN
SYSTEM ANTIDOTE
TRANSCRIPTIONAL
REPRESSOR XRE FAMILY

(Shewanella
oneidensis) 		no annotation 5 LEU D  76
ILE D  81
GLY D  80
VAL D  53
ILE D  33
 None
 1.06A 6emuC-4pu3D:
undetectable		 6emuC-4pu3D:
27.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r4z PNGF-II

(Elizabethkingia
meningoseptica) 		PF09112
(N-glycanase_N)
PF09113
(N-glycanase_C) 		5 LEU A 339
ILE A 223
GLY A 341
ILE A 253
ILE A 344
 None
 1.02A 6emuC-4r4zA:
undetectable		 6emuC-4r4zA:
15.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rt6 HEME/HEMOPEXIN-BINDI
NG PROTEIN

(Haemophilus
influenzae) 		PF05860
(Haemagg_act) 		5 LEU A 370
ILE A 335
GLY A 372
ASP A 328
ILE A 327
 None
 1.09A 6emuC-4rt6A:
undetectable		 6emuC-4rt6A:
12.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rt6 HEME/HEMOPEXIN-BINDI
NG PROTEIN

(Haemophilus
influenzae) 		PF05860
(Haemagg_act) 		5 LEU A 596
ILE A 601
GLY A 631
ILE A 510
ILE A 580
 None
 0.92A 6emuC-4rt6A:
undetectable		 6emuC-4rt6A:
12.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xcr SUPEROXIDE DISMUTASE
[CU-ZN]

(Homo sapiens) 		PF00080
(Sod_Cu) 		5 ILE A 106
GLY A 107
ILE A 108
ILE A  74
ILE A  82
 None
 1.05A 6emuC-4xcrA:
undetectable		 6emuC-4xcrA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ybr NICOTINATE-NUCLEOTID
E
ADENYLYLTRANSFERASE

(Mycobacterium
tuberculosis) 		PF01467
(CTP_transf_like) 		5 ILE A  78
GLY A  42
THR A  84
VAL A   8
VAL A  37
 None
None
NAP  A 301 (-3.9A)
None
None
 1.03A 6emuC-4ybrA:
2.3		 6emuC-4ybrA:
24.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yot 3-5 EXONUCLEASE
PHOEXO I

(Pyrococcus
horikoshii) 		PF13680
(DUF4152) 		5 ILE A 150
GLY A 149
ILE A 178
VAL A 203
ILE A 183
 None
 1.00A 6emuC-4yotA:
undetectable		 6emuC-4yotA:
25.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5a7t TRNA
(ADENINE(9)-N1)-METH
YLTRANSFERASE

(Sulfolobus
acidocaldarius) 		no annotation 8 LEU A 158
PRO A 160
ILE A 179
GLY A 180
ILE A 209
VAL A 218
ASP A 220
ILE A 225
 None
 0.37A 6emuC-5a7tA:
19.1		 6emuC-5a7tA:
33.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5a7y TRNA
(ADENINE(9)-N1)-METH
YLTRANSFERASE

(Sulfolobus
acidocaldarius) 		no annotation 7 LEU A 158
PRO A 160
ILE A 179
GLY A 180
ILE A 209
VAL A 218
ILE A 225
 SAH  A1291 (-4.0A)
SAH  A1291 (-3.8A)
SAH  A1291 (-4.3A)
SAH  A1291 (-3.7A)
SAH  A1291 (-4.0A)
SAH  A1291 (-4.6A)
SAH  A1291 (-4.3A)
 0.38A 6emuC-5a7yA:
undetectable		 6emuC-5a7yA:
32.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5a7y TRNA
(ADENINE(9)-N1)-METH
YLTRANSFERASE

(Sulfolobus
acidocaldarius) 		no annotation 6 PRO A 160
ILE A 179
ILE A 209
VAL A 218
ASP A 220
ILE A 225
 SAH  A1291 (-3.8A)
SAH  A1291 (-4.3A)
SAH  A1291 (-4.0A)
SAH  A1291 (-4.6A)
SAH  A1291 ( 4.3A)
SAH  A1291 (-4.3A)
 0.72A 6emuC-5a7yA:
undetectable		 6emuC-5a7yA:
32.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bk6 PUTATIVE AMIDASE

(Rhizobium
leguminosarum) 		no annotation 5 ILE A  35
GLY A 169
ILE A  65
ILE A 165
ILE A  33
 None
 1.03A 6emuC-5bk6A:
undetectable		 6emuC-5bk6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bk6 PUTATIVE AMIDASE

(Rhizobium
leguminosarum) 		no annotation 5 LEU A 167
GLY A 169
ILE A  65
ILE A 165
ILE A  33
 None
 1.04A 6emuC-5bk6A:
undetectable		 6emuC-5bk6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cvc SERINE RACEMASE

(Zea mays) 		PF00291
(PALP) 		5 ILE A 243
ILE A 295
VAL A 268
ASP A 270
ILE A 274
 None
 1.02A 6emuC-5cvcA:
undetectable		 6emuC-5cvcA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d79 BERBERINE BRIDGE
ENZYME-LIKE PROTEIN

(Arabidopsis
thaliana) 		PF01565
(FAD_binding_4)
PF08031
(BBE) 		5 LEU A 400
ILE A 398
VAL A 430
ASP A 369
ILE A 427
 None
 0.86A 6emuC-5d79A:
undetectable		 6emuC-5d79A:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ee0 OBG-LIKE ATPASE 1

(Oryza sativa) 		PF01926
(MMR_HSR1)
PF06071
(YchF-GTPase_C) 		5 LEU A 220
GLY A 107
THR A 149
VAL A 225
ILE A 116
 None
 0.94A 6emuC-5ee0A:
undetectable		 6emuC-5ee0A:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g5g PUTATIVE XANTHINE
DEHYDROGENASE YAGS
FAD-BINDING SUBUNIT

(Escherichia
coli) 		PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2) 		5 LEU C 368
ILE C 176
ILE C 363
ILE C 299
ILE C 291
 None
 0.96A 6emuC-5g5gC:
undetectable		 6emuC-5g5gC:
13.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j0c SUPEROXIDE DISMUTASE
[CU-ZN],SUPEROXIDE
DISMUTASE
[CU-ZN],OXIDOREDUCTA
SE,SUPEROXIDE
DISMUTASE [CU-ZN]

(Homo sapiens) 		PF00080
(Sod_Cu) 		5 ILE A  80
GLY A  81
ILE A  82
ILE A  48
ILE A  56
 None
 1.08A 6emuC-5j0cA:
undetectable		 6emuC-5j0cA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jbw 3-HYDROXYBUTYRYL-COA
DEHYDRATASE

(Myxococcus
xanthus) 		PF00378
(ECH_1) 		5 LEU A 128
ILE A 160
THR A 144
VAL A 174
ILE A 166
 None
 1.07A 6emuC-5jbwA:
undetectable		 6emuC-5jbwA:
24.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k8c 3-DEOXY-ALPHA-D-MANN
O-OCTULOSONATE
8-OXIDASE

(Shewanella
oneidensis) 		PF00465
(Fe-ADH) 		5 LEU A  97
ILE A 138
GLY A 137
ILE A  54
VAL A  56
 None
 1.01A 6emuC-5k8cA:
undetectable		 6emuC-5k8cA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lbd COPPER-TRANSPORTING
ATPASE PAA1,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF00702
(Hydrolase) 		5 LEU A 633
THR A 662
VAL A 687
VAL A 689
ILE A 651
 None
 0.98A 6emuC-5lbdA:
undetectable		 6emuC-5lbdA:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lkm DNA REPAIR PROTEIN
RADA

(Streptococcus
pneumoniae) 		PF13481
(AAA_25)
PF13541
(ChlI) 		5 ILE A  93
ILE A 175
VAL A 190
VAL A 193
ILE A 169
 None
 0.90A 6emuC-5lkmA:
undetectable		 6emuC-5lkmA:
17.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lly DIGUANYLATE CYCLASE
(GGDEF)
DOMAIN-CONTAINING
PROTEIN

(Idiomarina sp.
A28L) 		no annotation 5 ILE D 267
GLY D 268
ILE D 215
VAL D 244
ILE D 213
 None
 0.98A 6emuC-5llyD:
undetectable		 6emuC-5llyD:
17.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lmz FLUORINASE

(Streptomyces
sp. MA37) 		PF01887
(SAM_adeno_trans) 		5 LEU A 225
ILE A 230
GLY A 229
ILE A 220
VAL A 195
 None
 1.04A 6emuC-5lmzA:
undetectable		 6emuC-5lmzA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ovo ADP-RIBOSYL-(DINITRO
GEN REDUCTASE)
HYDROLASE
NITROGEN REGULATORY
PROTEIN P-II 1

(Azospirillum
brasilense;
Azospirillum
brasilense) 		no annotation
no annotation 		5 LEU B  20
ILE B  25
GLY B  24
ILE A 110
ILE B  77
 None
 0.83A 6emuC-5ovoB:
undetectable		 6emuC-5ovoB:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ub8 LIKELY RAB FAMILY
GTP-BINDING PROTEIN

(Candida
albicans) 		PF00071
(Ras) 		5 ILE A 121
ILE A 176
ILE A  93
VAL A 126
ILE A 123
 None
 0.85A 6emuC-5ub8A:
2.1		 6emuC-5ub8A:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v41 POLYKETIDE SYNTHASE
PKS13 (TERMINATION
POLYKETIDE SYNTHASE)

(Mycobacterium
tuberculosis) 		PF00975
(Thioesterase) 		5 ILE A1629
THR A1635
VAL A1614
VAL A1618
ILE A1625
 None
 1.07A 6emuC-5v41A:
undetectable		 6emuC-5v41A:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vg2 INTRADIOL
RING-CLEAVAGE
DIOXYGENASE

(Tetranychus
urticae) 		no annotation 5 LEU U 244
ILE U 228
GLY U 242
VAL U 107
ILE U 186
 None
 0.95A 6emuC-5vg2U:
undetectable		 6emuC-5vg2U:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xaq PROBABLE
D-TYROSYL-TRNA(TYR)
DEACYLASE 2

(Mus musculus) 		no annotation 5 LEU A  88
GLY A  41
ILE A  80
ILE A  90
VAL A  46
 None
 1.02A 6emuC-5xaqA:
undetectable		 6emuC-5xaqA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xni MCYF

(Microcystis
aeruginosa) 		no annotation 5 LEU A 116
ILE A 216
ILE A 111
ILE A 147
ILE A 192
 None
 0.99A 6emuC-5xniA:
2.4		 6emuC-5xniA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xyw RHINO
GD21652

(Drosophila
simulans;
Drosophila
simulans) 		no annotation
no annotation 		5 THR C  21
THR C  22
ILE A 479
VAL A 463
ASP A 472
 None
 0.95A 6emuC-5xywC:
undetectable		 6emuC-5xywC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yo8 TETRAPRENYL-BETA-CUR
CUMENE SYNTHASE

(Bacillus
alcalophilus) 		no annotation 5 ILE A  61
GLY A  60
ILE A  74
ASP A  17
ILE A  14
 None
 1.00A 6emuC-5yo8A:
undetectable		 6emuC-5yo8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ems TRNA
(GUANINE(9)-/ADENINE
(9)-N1)-METHYLTRANSF
ERASE

(Thermococcus
kodakarensis) 		no annotation 5 LEU A 181
ILE A 201
GLY A 202
ILE A 234
ILE A 250
 None
 0.77A 6emuC-6emsA:
7.9		 6emuC-6emsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ems TRNA
(GUANINE(9)-/ADENINE
(9)-N1)-METHYLTRANSF
ERASE

(Thermococcus
kodakarensis) 		no annotation 5 LEU A 181
PRO A 183
GLY A 202
ILE A 234
ILE A 250
 None
 0.77A 6emuC-6emsA:
7.9		 6emuC-6emsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6emv TRNA
(GUANINE(9)-/ADENINE
(9)-N1)-METHYLTRANSF
ERASE

(Thermococcus
kodakarensis) 		no annotation 12 LEU A 181
PRO A 183
ILE A 201
GLY A 202
ILE A 204
THR A 214
THR A 215
ILE A 234
VAL A 240
VAL A 243
ASP A 245
ILE A 250
 SAH  A 301 (-4.0A)
SAH  A 301 (-3.9A)
SAH  A 301 ( 4.6A)
SAH  A 301 (-3.0A)
SAH  A 301 (-4.1A)
SAH  A 301 (-3.8A)
SAH  A 301 (-3.7A)
SAH  A 301 (-3.9A)
SAH  A 301 ( 4.7A)
SAH  A 301 ( 4.9A)
SAH  A 301 (-4.5A)
SAH  A 301 (-4.1A)
 0.34A 6emuC-6emvA:
32.9		 6emuC-6emvA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6et7 DIGUANYLATE CYCLASE
(GGDEF)
DOMAIN-CONTAINING
PROTEIN

(Idiomarina sp.
A28L) 		no annotation 5 ILE A 267
GLY A 268
ILE A 215
VAL A 244
ILE A 213
 None
 0.96A 6emuC-6et7A:
undetectable		 6emuC-6et7A:
undetectable