SIMILAR PATTERNS OF AMINO ACIDS FOR 6EMU_B_SAMB301

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1anu COHESIN-2

(Ruminiclostridium
thermocellum) 		PF00963
(Cohesin) 		5 ILE A  47
GLY A  48
ILE A  49
VAL A   8
VAL A 136
 None
 1.03A 6emuB-1anuA:
undetectable		 6emuB-1anuA:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1im8 YECO

(Haemophilus
influenzae) 		PF13649
(Methyltransf_25) 		5 GLY A  46
ILE A  45
ILE A 108
VAL A 110
ILE A  77
 None
 0.76A 6emuB-1im8A:
undetectable		 6emuB-1im8A:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l9w 3-DEHYDROQUINATE
DEHYDRATASE AROD

(Salmonella
enterica) 		PF01487
(DHquinase_I) 		5 LEU A  78
PRO A  76
THR A   5
ASP A  43
ILE A  19
 None
 1.05A 6emuB-1l9wA:
2.4		 6emuB-1l9wA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n2o PANTOTHENATE
SYNTHETASE

(Mycobacterium
tuberculosis) 		PF02569
(Pantoate_ligase) 		5 LEU A 268
ILE A 285
GLY A 266
ILE A 255
ILE A 283
 None
 1.07A 6emuB-1n2oA:
2.2		 6emuB-1n2oA:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o12 N-ACETYLGLUCOSAMINE-
6-PHOSPHATE
DEACETYLASE

(Thermotoga
maritima) 		PF01979
(Amidohydro_1) 		5 ILE A 210
GLY A 211
ILE A 212
VAL A 241
VAL A 244
 None
 0.96A 6emuB-1o12A:
undetectable		 6emuB-1o12A:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pvt SUGAR-PHOSPHATE
ALDOLASE

(Thermotoga
maritima) 		PF00596
(Aldolase_II) 		5 LEU A  59
ILE A 121
ILE A  77
VAL A  70
ILE A   8
 None
 1.00A 6emuB-1pvtA:
undetectable		 6emuB-1pvtA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q50 GLUCOSE-6-PHOSPHATE
ISOMERASE

(Leishmania
mexicana) 		PF00342
(PGI) 		5 LEU A 298
GLY A 203
ILE A 204
VAL A 322
ILE A 332
 None
 0.97A 6emuB-1q50A:
2.5		 6emuB-1q50A:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t0i YLR011WP

(Saccharomyces
cerevisiae) 		PF03358
(FMN_red) 		5 ILE A   5
GLY A   4
ILE A  88
ILE A 177
VAL A 151
 None
 1.03A 6emuB-1t0iA:
2.3		 6emuB-1t0iA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t6k PHENAZINE
BIOSYNTHESIS PROTEIN
PHZF

(Pseudomonas
fluorescens) 		PF02567
(PhzC-PhzF) 		5 LEU A 134
ILE A 139
GLY A 138
ILE A 146
VAL A 156
 None
 0.91A 6emuB-1t6kA:
undetectable		 6emuB-1t6kA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x9e HMG-COA SYNTHASE

(Enterococcus
faecalis) 		PF01154
(HMG_CoA_synt_N)
PF08540
(HMG_CoA_synt_C) 		5 ILE A 107
GLY A 113
VAL A 162
VAL A 133
ILE A  75
 None
 1.07A 6emuB-1x9eA:
undetectable		 6emuB-1x9eA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ye8 HYPOTHETICAL UPF0334
KINASE-LIKE PROTEIN
AQ_1292

(Aquifex
aeolicus) 		PF03266
(NTPase_1) 		5 LEU A 169
THR A 161
ILE A  20
VAL A 134
ILE A 172
 None
 0.84A 6emuB-1ye8A:
undetectable		 6emuB-1ye8A:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a9v GMP SYNTHASE

(Thermoplasma
acidophilum) 		PF00117
(GATase) 		5 PRO A  75
ILE A 184
GLY A 185
ASP A  44
ILE A   4
 None
 1.01A 6emuB-2a9vA:
undetectable		 6emuB-2a9vA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2btm PROTEIN
(TRIOSEPHOSPHATE
ISOMERASE)

(Geobacillus
stearothermophilus) 		PF00121
(TIM) 		5 LEU A  46
GLY A  86
VAL A  19
VAL A  22
ILE A  60
 None
 1.06A 6emuB-2btmA:
undetectable		 6emuB-2btmA:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c2y METHYLENETETRAHYDROF
OLATE
DEHYDROGENASE-METHEN
YLTETRAHYDROFOLATE
CYCLOHYDROLASE

(Mycobacterium
tuberculosis) 		PF00763
(THF_DHG_CYH)
PF02882
(THF_DHG_CYH_C) 		5 LEU A 216
GLY A 212
VAL A 228
VAL A 207
ILE A 164
 None
 0.87A 6emuB-2c2yA:
2.1		 6emuB-2c2yA:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c4t 5'-FLUORO-5'-DEOXYAD
ENOSINE SYNTHASE

(Streptomyces
cattleya) 		PF01887
(SAM_adeno_trans) 		5 LEU A 225
ILE A 230
GLY A 229
ILE A 220
VAL A 195
 None
 0.92A 6emuB-2c4tA:
3.0		 6emuB-2c4tA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ccl CELLULOSOMAL
SCAFFOLDING PROTEIN
A

(Ruminiclostridium
thermocellum) 		PF00963
(Cohesin) 		5 ILE A  52
GLY A  53
ILE A  54
VAL A  13
VAL A 141
 None
 1.01A 6emuB-2cclA:
undetectable		 6emuB-2cclA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2czc GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE

(Pyrococcus
horikoshii) 		PF01113
(DapB_N)
PF02800
(Gp_dh_C) 		5 ILE A 237
ILE A 235
VAL A 221
VAL A 223
ILE A 153
 None
 1.06A 6emuB-2czcA:
4.8		 6emuB-2czcA:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fko 173AA LONG
HYPOTHETICAL
FERRIPYOCHELIN
BINDING PROTEIN

(Pyrococcus
horikoshii) 		PF00132
(Hexapep) 		5 ILE A  97
GLY A  98
ILE A  99
ILE A  64
ILE A  80
 None
 1.02A 6emuB-2fkoA:
undetectable		 6emuB-2fkoA:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g85 CHORISMATE SYNTHASE

(Mycobacterium
tuberculosis) 		PF01264
(Chorismate_synt) 		5 ILE A  73
GLY A  62
ILE A  33
VAL A  57
ILE A  75
 None
 0.98A 6emuB-2g85A:
undetectable		 6emuB-2g85A:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2glx 1,5-ANHYDRO-D-FRUCTO
SE REDUCTASE

(Ensifer
adhaerens) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		5 LEU A 250
ILE A 141
GLY A 245
ILE A 145
ILE A 136
 None
 1.07A 6emuB-2glxA:
2.9		 6emuB-2glxA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ho9 CHEMOTAXIS PROTEIN
CHEW

(Escherichia
coli) 		PF01584
(CheW) 		5 LEU A  20
ILE A  31
GLY A  30
VAL A  87
ILE A  89
 None
 0.97A 6emuB-2ho9A:
undetectable		 6emuB-2ho9A:
24.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hti BH0577 PROTEIN

(Bacillus
halodurans) 		PF12900
(Pyridox_ox_2) 		5 ILE A  62
GLY A  59
ILE A 103
VAL A  71
ILE A  65
 None
FAD  A 200 (-3.2A)
None
None
None
 0.94A 6emuB-2htiA:
undetectable		 6emuB-2htiA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j5b TYROSYL-TRNA
SYNTHETASE

(Acanthamoeba
polyphaga
mimivirus) 		PF00579
(tRNA-synt_1b) 		5 LEU A 172
ILE A 177
GLY A 176
ILE A 111
ILE A  66
 LEU  A 172 ( 0.6A)
ILE  A 177 ( 0.7A)
GLY  A 176 ( 0.0A)
ILE  A 111 ( 0.7A)
ILE  A  66 ( 0.4A)
 1.07A 6emuB-2j5bA:
3.2		 6emuB-2j5bA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o0o TNF SUPERFAMILY
LIGAND TL1A

(Homo sapiens) 		PF00229
(TNF) 		5 LEU A 195
GLY A 197
ILE A 212
ILE A 149
ILE A 181
 None
 1.00A 6emuB-2o0oA:
undetectable		 6emuB-2o0oA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q2v BETA-D-HYDROXYBUTYRA
TE DEHYDROGENASE

(Pseudomonas
putida) 		PF00106
(adh_short) 		5 LEU A 227
ILE A  17
GLY A  18
ILE A 180
ILE A 137
 None
 1.06A 6emuB-2q2vA:
undetectable		 6emuB-2q2vA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ral SERINE-ASPARTATE
REPEAT-CONTAINING
PROTEIN G

(Staphylococcus
epidermidis) 		PF10425
(SdrG_C_C) 		5 ILE A 346
GLY A 360
THR A 326
ILE A 331
ASP A 363
 None
 0.84A 6emuB-2ralA:
undetectable		 6emuB-2ralA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wan PULLULANASE

(Bacillus
acidopullulyticus) 		PF00128
(Alpha-amylase)
PF02922
(CBM_48) 		5 LEU A 648
ILE A 676
GLY A 677
ILE A 729
VAL A 552
 None
 0.96A 6emuB-2wanA:
undetectable		 6emuB-2wanA:
11.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ycj 5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE

(Carboxydothermus
hydrogenoformans) 		PF00809
(Pterin_bind) 		5 ILE A  16
GLY A  11
ILE A  65
ASP A  44
ILE A   9
 None
None
None
C2F  A3000 ( 4.5A)
None
 0.92A 6emuB-2ycjA:
3.5		 6emuB-2ycjA:
24.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yfs LEVANSUCRASE

(Lactobacillus
johnsonii) 		PF02435
(Glyco_hydro_68) 		5 LEU A 309
ILE A 294
GLY A 295
ILE A 388
ILE A 328
 None
 0.79A 6emuB-2yfsA:
undetectable		 6emuB-2yfsA:
16.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a9x SELENOCYSTEINE LYASE

(Rattus
norvegicus) 		PF00266
(Aminotran_5) 		5 ILE A 253
GLY A 254
ILE A 243
ILE A  63
ILE A 290
 None
 1.05A 6emuB-3a9xA:
undetectable		 6emuB-3a9xA:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dm9 SIGNAL RECOGNITION
PARTICLE RECEPTOR

(Pyrococcus
furiosus) 		PF00448
(SRP54)
PF02881
(SRP54_N) 		5 ILE B 240
THR B 137
VAL B 154
VAL B 208
ILE B 126
 None
PO4  B 323 (-3.6A)
None
None
None
 1.07A 6emuB-3dm9B:
2.9		 6emuB-3dm9B:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dnf 4-HYDROXY-3-METHYLBU
T-2-ENYL DIPHOSPHATE
REDUCTASE

(Aquifex
aeolicus) 		PF02401
(LYTB) 		5 ILE A 142
GLY A 141
THR A 110
ILE A 179
VAL A 183
 None
 0.97A 6emuB-3dnfA:
2.4		 6emuB-3dnfA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dnf 4-HYDROXY-3-METHYLBU
T-2-ENYL DIPHOSPHATE
REDUCTASE

(Aquifex
aeolicus) 		PF02401
(LYTB) 		5 ILE A 150
GLY A 151
ILE A 161
VAL A 186
ILE A 179
 None
 1.03A 6emuB-3dnfA:
2.4		 6emuB-3dnfA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3etc AMP-BINDING PROTEIN

(Methanosarcina
acetivorans) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		5 LEU A 228
ILE A  26
THR A 355
ILE A 267
ILE A 231
 None
GOL  A1002 (-4.2A)
None
None
None
 0.99A 6emuB-3etcA:
2.1		 6emuB-3etcA:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fd0 PUTATIVE
CYSTATHIONINE
BETA-LYASE INVOLVED
IN ALUMINUM
RESISTANCE

(Listeria
innocua) 		PF06838
(Met_gamma_lyase) 		5 GLY A 144
ILE A 106
VAL A 151
ASP A 147
ILE A 146
 None
None
None
None
EDO  A 413 (-4.3A)
 0.83A 6emuB-3fd0A:
undetectable		 6emuB-3fd0A:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fdx PUTATIVE FILAMENT
PROTEIN / UNIVERSAL
STRESS PROTEIN F

(Klebsiella
pneumoniae) 		PF00582
(Usp) 		5 ILE A   2
ILE A  27
ILE A  17
VAL A 140
ILE A 109
 None
 1.02A 6emuB-3fdxA:
3.6		 6emuB-3fdxA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gtt SUPEROXIDE DISMUTASE
[CU-ZN]

(Mus musculus) 		PF00080
(Sod_Cu) 		5 ILE A 149
GLY A 150
ILE A 151
ILE A 104
ILE A 112
 None
 1.02A 6emuB-3gttA:
undetectable		 6emuB-3gttA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i16 ALUMINUM RESISTANCE
PROTEIN

(Clostridium
novyi) 		PF06838
(Met_gamma_lyase) 		5 ILE A 417
GLY A 416
ILE A 419
THR A 353
ILE A 336
 None
 0.85A 6emuB-3i16A:
undetectable		 6emuB-3i16A:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jcm U4/U6 SMALL NUCLEAR
RIBONUCLEOPROTEIN
PRP4

(Saccharomyces
cerevisiae) 		PF00400
(WD40) 		5 LEU B 443
ILE B 440
GLY B 455
ILE B 178
THR B 192
 None
 1.06A 6emuB-3jcmB:
undetectable		 6emuB-3jcmB:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3luz EXTRAGENIC
SUPPRESSOR PROTEIN
SUHB

(Bartonella
henselae) 		PF00459
(Inositol_P) 		5 LEU A 192
GLY A 188
THR A  92
ILE A 118
ASP A 214
 None
 1.02A 6emuB-3luzA:
undetectable		 6emuB-3luzA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m7n PUTATIVE
UNCHARACTERIZED
PROTEIN AF_0206

(Archaeoglobus
fulgidus) 		PF10447
(EXOSC1)
PF14382
(ECR1_N) 		5 LEU A  95
ILE A  75
GLY A  93
ILE A 108
ASP A  67
 None
 1.02A 6emuB-3m7nA:
undetectable		 6emuB-3m7nA:
23.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n0a TYROSINE-PROTEIN
PHOSPHATASE AUXILIN

(Bos taurus) 		PF10409
(PTEN_C2) 		5 LEU A 228
ILE A 327
GLY A 325
VAL A 254
VAL A 295
 None
 1.05A 6emuB-3n0aA:
2.1		 6emuB-3n0aA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rlc A1 PROTEIN

(Escherichia
virus Qbeta) 		PF16814
(Read-through) 		5 ILE A 283
GLY A 290
ILE A 319
ASP A 234
ILE A 292
 None
 1.03A 6emuB-3rlcA:
undetectable		 6emuB-3rlcA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tlm SARCOPLASMIC/ENDOPLA
SMIC RETICULUM
CALCIUM ATPASE 1

(Bos taurus) 		PF00122
(E1-E2_ATPase)
PF00689
(Cation_ATPase_C)
PF00690
(Cation_ATPase_N)
PF08282
(Hydrolase_3)
PF13246
(Cation_ATPase) 		5 GLY A 148
THR A 226
ILE A 220
VAL A 153
ILE A 150
 None
 0.92A 6emuB-3tlmA:
undetectable		 6emuB-3tlmA:
11.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ue3 SEPTUM FORMATION,
PENICILLIN BINDING
PROTEIN 3,
PEPTIDOGLYCAN
SYNTHETASE

(Acinetobacter
sp. ATCC 27244) 		PF00905
(Transpeptidase)
PF03717
(PBP_dimer) 		5 LEU A 219
ILE A 206
GLY A 207
ILE A 260
ILE A  79
 None
 0.93A 6emuB-3ue3A:
undetectable		 6emuB-3ue3A:
17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uug MULTIPLE
SUGAR-BINDING
PERIPLASMIC RECEPTOR
CHVE

(Agrobacterium
fabrum) 		PF13407
(Peripla_BP_4) 		5 LEU A 209
GLY A 240
ILE A 134
VAL A 205
ILE A 119
 None
 0.80A 6emuB-3uugA:
2.1		 6emuB-3uugA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vr5 V-TYPE SODIUM ATPASE
CATALYTIC SUBUNIT A

(Enterococcus
hirae) 		PF00006
(ATP-synt_ab)
PF02874
(ATP-synt_ab_N)
PF16886
(ATP-synt_ab_Xtn) 		5 ILE A 311
GLY A 310
ILE A 313
VAL A 251
ILE A 384
 None
 0.97A 6emuB-3vr5A:
undetectable		 6emuB-3vr5A:
14.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aee ALPHA AMYLASE,
CATALYTIC REGION

(Staphylothermus
marinus) 		PF00128
(Alpha-amylase) 		5 ILE A 267
GLY A 266
ILE A 287
ASP A 234
ILE A 233
 None
 1.07A 6emuB-4aeeA:
undetectable		 6emuB-4aeeA:
14.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bbm CYCLIN-DEPENDENT
KINASE-LIKE 2

(Homo sapiens) 		PF00069
(Pkinase) 		5 LEU A 191
ILE A 188
ILE A 132
VAL A 140
ILE A 110
 None
 1.05A 6emuB-4bbmA:
undetectable		 6emuB-4bbmA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c8q DNA TOPOISOMERASE
2-ASSOCIATED PROTEIN
PAT1

(Saccharomyces
cerevisiae) 		PF09770
(PAT1) 		5 ILE H 533
GLY H 532
ILE H 535
ILE H 555
ILE H 591
 None
 0.94A 6emuB-4c8qH:
undetectable		 6emuB-4c8qH:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cr2 26S PROTEASE
REGULATORY SUBUNIT 4
HOMOLOG

(Saccharomyces
cerevisiae) 		PF00004
(AAA) 		5 LEU I 109
GLY I 107
ILE I 106
VAL I 136
ILE I 156
 None
 0.94A 6emuB-4cr2I:
undetectable		 6emuB-4cr2I:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hw9 MECHANOSENSITIVE
CHANNEL MSCS

(Helicobacter
pylori) 		PF00924
(MS_channel) 		5 ILE A 212
GLY A 213
ILE A 214
ILE A 247
ILE A 194
 None
 0.90A 6emuB-4hw9A:
undetectable		 6emuB-4hw9A:
25.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4igg CATENIN ALPHA-1

(Homo sapiens) 		PF01044
(Vinculin) 		5 GLY A 621
ILE A 625
THR A 576
ILE A 545
ILE A 519
 None
 0.98A 6emuB-4iggA:
undetectable		 6emuB-4iggA:
13.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k46 ADENYLATE KINASE

(Photobacterium
profundum) 		PF00406
(ADK)
PF05191
(ADK_lid) 		5 LEU A   5
ILE A 179
ILE A   3
VAL A 103
ILE A 107
 None
 0.95A 6emuB-4k46A:
undetectable		 6emuB-4k46A:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kq7 HYPOTHETICAL PROTEIN

(Bacteroides
uniformis) 		PF11175
(DUF2961) 		5 ILE A 137
GLY A 138
ILE A 190
ASP A 118
ILE A 119
 None
 0.91A 6emuB-4kq7A:
undetectable		 6emuB-4kq7A:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m9c BACTERIAL
TRANSFERASE
HEXAPEPTIDE (THREE
REPEATS) FAMILY
PROTEIN

(Acinetobacter
baumannii) 		PF00132
(Hexapep) 		5 ILE A 158
GLY A 156
THR A 119
ILE A 166
ILE A 172
 None
 1.07A 6emuB-4m9cA:
3.8		 6emuB-4m9cA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mzu WXCM-LIKE PROTEIN

(Shewanella
denitrificans) 		PF00132
(Hexapep)
PF05523
(FdtA) 		5 ILE A 115
GLY A 114
ILE A 105
VAL A  77
ILE A 111
 None
 0.82A 6emuB-4mzuA:
undetectable		 6emuB-4mzuA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pu3 TOXIN-ANTITOXIN
SYSTEM ANTIDOTE
TRANSCRIPTIONAL
REPRESSOR XRE FAMILY

(Shewanella
oneidensis) 		no annotation 5 LEU D  76
ILE D  81
GLY D  80
VAL D  53
ILE D  33
 None
 0.96A 6emuB-4pu3D:
undetectable		 6emuB-4pu3D:
27.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qgr DEGT/DNRJ/ERYC1/STRS
AMINOTRANSFERASE

(Brucella
abortus) 		PF01041
(DegT_DnrJ_EryC1) 		5 LEU A  66
ILE A  71
GLY A  70
ILE A 160
VAL A 182
 None
 1.06A 6emuB-4qgrA:
undetectable		 6emuB-4qgrA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qmg STAPHYLOCOCCAL
NUCLEASE
DOMAIN-CONTAINING
PROTEIN 1

(Homo sapiens) 		PF00565
(SNase) 		5 GLY A 282
ILE A 199
VAL A 202
VAL A 208
ILE A 277
 None
 0.93A 6emuB-4qmgA:
undetectable		 6emuB-4qmgA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r0j UNCHARACTERIZED
PROTEIN

(Streptococcus
mutans) 		PF09704
(Cas_Cas5d) 		5 PRO A  37
GLY A 140
VAL A  62
VAL A  99
ILE A  45
 None
 1.06A 6emuB-4r0jA:
undetectable		 6emuB-4r0jA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r12 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Dictyostelium
purpureum) 		PF05450
(Nicastrin) 		5 ILE A 233
ILE A 375
VAL A 379
ASP A 457
ILE A 459
 None
 1.06A 6emuB-4r12A:
1.9		 6emuB-4r12A:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r4z PNGF-II

(Elizabethkingia
meningoseptica) 		PF09112
(N-glycanase_N)
PF09113
(N-glycanase_C) 		5 LEU A 339
ILE A 223
GLY A 341
ILE A 253
ILE A 344
 None
 1.01A 6emuB-4r4zA:
undetectable		 6emuB-4r4zA:
15.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rt6 HEME/HEMOPEXIN-BINDI
NG PROTEIN

(Haemophilus
influenzae) 		PF05860
(Haemagg_act) 		5 LEU A 596
ILE A 601
GLY A 631
ILE A 510
ILE A 580
 None
 0.92A 6emuB-4rt6A:
undetectable		 6emuB-4rt6A:
12.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v1u LYND

(Lyngbya
aestuarii) 		PF02624
(YcaO) 		5 THR A 126
ILE A 139
VAL A 141
VAL A 114
ILE A 264
 None
 0.99A 6emuB-4v1uA:
undetectable		 6emuB-4v1uA:
12.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xcr SUPEROXIDE DISMUTASE
[CU-ZN]

(Homo sapiens) 		PF00080
(Sod_Cu) 		5 ILE A 106
GLY A 107
ILE A 108
ILE A  74
ILE A  82
 None
 1.05A 6emuB-4xcrA:
undetectable		 6emuB-4xcrA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yhs MONOSACCHARIDE ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN, CUT2 FAMILY

(Bradyrhizobium
sp. BTAi1) 		PF13407
(Peripla_BP_4) 		5 LEU A 129
ILE A 150
ILE A 108
VAL A 112
ILE A 121
 None
 1.06A 6emuB-4yhsA:
undetectable		 6emuB-4yhsA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yot 3-5 EXONUCLEASE
PHOEXO I

(Pyrococcus
horikoshii) 		PF13680
(DUF4152) 		5 ILE A 150
GLY A 149
ILE A 178
VAL A 203
ILE A 183
 None
 1.01A 6emuB-4yotA:
undetectable		 6emuB-4yotA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zjp MONOSACCHARIDE-TRANS
PORTING ATPASE

(Actinobacillus
succinogenes) 		PF13407
(Peripla_BP_4) 		5 LEU A 111
ILE A 262
ILE A 109
VAL A 120
ILE A 124
 None
 1.04A 6emuB-4zjpA:
4.8		 6emuB-4zjpA:
24.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5a7t TRNA
(ADENINE(9)-N1)-METH
YLTRANSFERASE

(Sulfolobus
acidocaldarius) 		no annotation 8 LEU A 158
PRO A 160
ILE A 179
GLY A 180
ILE A 209
VAL A 218
ASP A 220
ILE A 225
 None
 0.39A 6emuB-5a7tA:
19.2		 6emuB-5a7tA:
33.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5a7y TRNA
(ADENINE(9)-N1)-METH
YLTRANSFERASE

(Sulfolobus
acidocaldarius) 		no annotation 5 ILE A 179
ILE A 209
VAL A 218
ASP A 220
ILE A 225
 SAH  A1291 (-4.3A)
SAH  A1291 (-4.0A)
SAH  A1291 (-4.6A)
SAH  A1291 ( 4.3A)
SAH  A1291 (-4.3A)
 0.76A 6emuB-5a7yA:
16.7		 6emuB-5a7yA:
32.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5a7y TRNA
(ADENINE(9)-N1)-METH
YLTRANSFERASE

(Sulfolobus
acidocaldarius) 		no annotation 7 LEU A 158
PRO A 160
ILE A 179
GLY A 180
ILE A 209
VAL A 218
ILE A 225
 SAH  A1291 (-4.0A)
SAH  A1291 (-3.8A)
SAH  A1291 (-4.3A)
SAH  A1291 (-3.7A)
SAH  A1291 (-4.0A)
SAH  A1291 (-4.6A)
SAH  A1291 (-4.3A)
 0.40A 6emuB-5a7yA:
16.7		 6emuB-5a7yA:
32.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bk6 PUTATIVE AMIDASE

(Rhizobium
leguminosarum) 		no annotation 5 ILE A  35
GLY A 169
ILE A  65
ILE A 165
ILE A  33
 None
 1.02A 6emuB-5bk6A:
undetectable		 6emuB-5bk6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bk6 PUTATIVE AMIDASE

(Rhizobium
leguminosarum) 		no annotation 5 LEU A 167
GLY A 169
ILE A  65
ILE A 165
ILE A  33
 None
 1.06A 6emuB-5bk6A:
undetectable		 6emuB-5bk6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ecu CELLULASE

(Caldicellulosiruptor
saccharolyticus) 		PF00150
(Cellulase)
PF03424
(CBM_17_28) 		5 ILE A 227
THR A 284
ILE A 134
VAL A 130
ILE A 181
 None
 1.04A 6emuB-5ecuA:
2.0		 6emuB-5ecuA:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ee0 OBG-LIKE ATPASE 1

(Oryza sativa) 		PF01926
(MMR_HSR1)
PF06071
(YchF-GTPase_C) 		5 LEU A 220
GLY A 107
THR A 149
VAL A 225
ILE A 116
 None
 0.97A 6emuB-5ee0A:
undetectable		 6emuB-5ee0A:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fip GH5 CELLULASE

(unidentified) 		PF00150
(Cellulase)
PF03424
(CBM_17_28) 		5 ILE A 231
THR A 293
ILE A 138
VAL A 134
ILE A 185
 None
 1.02A 6emuB-5fipA:
undetectable		 6emuB-5fipA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g5g PUTATIVE XANTHINE
DEHYDROGENASE YAGS
FAD-BINDING SUBUNIT

(Escherichia
coli) 		PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2) 		5 LEU C 368
ILE C 176
ILE C 363
ILE C 299
ILE C 291
 None
 0.95A 6emuB-5g5gC:
undetectable		 6emuB-5g5gC:
13.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j0c SUPEROXIDE DISMUTASE
[CU-ZN],SUPEROXIDE
DISMUTASE
[CU-ZN],OXIDOREDUCTA
SE,SUPEROXIDE
DISMUTASE [CU-ZN]

(Homo sapiens) 		PF00080
(Sod_Cu) 		5 ILE A  80
GLY A  81
ILE A  82
ILE A  48
ILE A  56
 None
 1.08A 6emuB-5j0cA:
undetectable		 6emuB-5j0cA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j0f SUPEROXIDE DISMUTASE
[CU-ZN],OXIDOREDUCTA
SE,SUPEROXIDE
DISMUTASE [CU-ZN]

(Homo sapiens) 		PF00080
(Sod_Cu) 		5 ILE A  56
GLY A  57
ILE A  58
ILE A  24
ILE A  32
 None
 1.07A 6emuB-5j0fA:
undetectable		 6emuB-5j0fA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jbw 3-HYDROXYBUTYRYL-COA
DEHYDRATASE

(Myxococcus
xanthus) 		PF00378
(ECH_1) 		5 LEU A 128
ILE A 160
THR A 144
VAL A 174
ILE A 166
 None
 1.02A 6emuB-5jbwA:
undetectable		 6emuB-5jbwA:
24.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lbd COPPER-TRANSPORTING
ATPASE PAA1,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF00702
(Hydrolase) 		5 LEU A 633
THR A 662
VAL A 687
VAL A 689
ILE A 651
 None
 0.93A 6emuB-5lbdA:
undetectable		 6emuB-5lbdA:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lly DIGUANYLATE CYCLASE
(GGDEF)
DOMAIN-CONTAINING
PROTEIN

(Idiomarina sp.
A28L) 		no annotation 5 ILE D 267
GLY D 268
ILE D 215
VAL D 244
ILE D 213
 None
 0.97A 6emuB-5llyD:
undetectable		 6emuB-5llyD:
17.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lmg DNA TOPOISOMERASE
2-ASSOCIATED PROTEIN
PAT1

(Saccharomyces
cerevisiae) 		PF09770
(PAT1) 		5 ILE A 533
GLY A 532
ILE A 535
ILE A 555
ILE A 591
 None
 1.07A 6emuB-5lmgA:
undetectable		 6emuB-5lmgA:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lmz FLUORINASE

(Streptomyces
sp. MA37) 		PF01887
(SAM_adeno_trans) 		5 LEU A 225
ILE A 230
GLY A 229
ILE A 220
VAL A 195
 None
 1.03A 6emuB-5lmzA:
undetectable		 6emuB-5lmzA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ovo ADP-RIBOSYL-(DINITRO
GEN REDUCTASE)
HYDROLASE
NITROGEN REGULATORY
PROTEIN P-II 1

(Azospirillum
brasilense;
Azospirillum
brasilense) 		no annotation
no annotation 		5 LEU B  20
ILE B  25
GLY B  24
ILE A 110
ILE B  77
 None
 0.85A 6emuB-5ovoB:
undetectable		 6emuB-5ovoB:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uf8 POTENTIAL
ADP-RIBOSYLATION
FACTOR

(Candida
albicans) 		PF00025
(Arf) 		5 LEU A 121
PRO A 152
ILE A  88
GLY A  87
ASP A 118
 None
 0.80A 6emuB-5uf8A:
4.0		 6emuB-5uf8A:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uf8 POTENTIAL
ADP-RIBOSYLATION
FACTOR

(Candida
albicans) 		PF00025
(Arf) 		5 LEU A 121
PRO A 152
ILE A  88
GLY A  87
ILE A 148
 None
 0.71A 6emuB-5uf8A:
4.0		 6emuB-5uf8A:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vg2 INTRADIOL
RING-CLEAVAGE
DIOXYGENASE

(Tetranychus
urticae) 		no annotation 5 LEU U 244
ILE U 228
GLY U 242
VAL U 107
ILE U 186
 None
 0.88A 6emuB-5vg2U:
undetectable		 6emuB-5vg2U:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xaq PROBABLE
D-TYROSYL-TRNA(TYR)
DEACYLASE 2

(Mus musculus) 		no annotation 5 LEU A  88
GLY A  41
ILE A  80
ILE A  90
VAL A  46
 None
 1.06A 6emuB-5xaqA:
undetectable		 6emuB-5xaqA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xni MCYF

(Microcystis
aeruginosa) 		no annotation 5 LEU A 116
ILE A 216
ILE A 111
ILE A 147
ILE A 192
 None
 0.98A 6emuB-5xniA:
2.5		 6emuB-5xniA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yo8 TETRAPRENYL-BETA-CUR
CUMENE SYNTHASE

(Bacillus
alcalophilus) 		no annotation 5 ILE A  61
GLY A  60
ILE A  74
ASP A  17
ILE A  14
 None
 1.01A 6emuB-5yo8A:
undetectable		 6emuB-5yo8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zw4 PUTATIVE
O-METHYLTRANSFERASE
YRRM

(Bacillus
subtilis) 		no annotation 5 LEU A  59
ILE A 157
ILE A  84
ASP A 133
ILE A  61
 None
None
SAM  A 302 ( 4.7A)
SAM  A 302 (-3.6A)
None
 1.07A 6emuB-5zw4A:
2.6		 6emuB-5zw4A:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c5d LLAJI.R1

(Helicobacter
pylori) 		no annotation 5 ILE A  12
ILE A  87
ILE A  69
VAL A  73
ASP A  89
 None
 0.99A 6emuB-6c5dA:
undetectable		 6emuB-6c5dA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ems TRNA
(GUANINE(9)-/ADENINE
(9)-N1)-METHYLTRANSF
ERASE

(Thermococcus
kodakarensis) 		no annotation 5 LEU A 181
ILE A 201
GLY A 202
ILE A 234
ILE A 250
 None
 0.77A 6emuB-6emsA:
25.8		 6emuB-6emsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ems TRNA
(GUANINE(9)-/ADENINE
(9)-N1)-METHYLTRANSF
ERASE

(Thermococcus
kodakarensis) 		no annotation 5 LEU A 181
PRO A 183
GLY A 202
ILE A 234
ILE A 250
 None
 0.75A 6emuB-6emsA:
25.8		 6emuB-6emsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ems TRNA
(GUANINE(9)-/ADENINE
(9)-N1)-METHYLTRANSF
ERASE

(Thermococcus
kodakarensis) 		no annotation 5 LEU A 181
PRO A 183
TRP A 184
ILE A 234
ILE A 250
 None
 0.73A 6emuB-6emsA:
25.8		 6emuB-6emsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6emv TRNA
(GUANINE(9)-/ADENINE
(9)-N1)-METHYLTRANSF
ERASE

(Thermococcus
kodakarensis) 		no annotation 12 LEU A 181
PRO A 183
TRP A 184
ILE A 201
GLY A 202
ILE A 204
THR A 214
ILE A 234
VAL A 240
VAL A 243
ASP A 245
ILE A 250
 SAH  A 301 (-4.0A)
SAH  A 301 (-3.9A)
SAH  A 301 (-4.6A)
SAH  A 301 ( 4.6A)
SAH  A 301 (-3.0A)
SAH  A 301 (-4.1A)
SAH  A 301 (-3.8A)
SAH  A 301 (-3.9A)
SAH  A 301 ( 4.7A)
SAH  A 301 ( 4.9A)
SAH  A 301 (-4.5A)
SAH  A 301 (-4.1A)
 0.33A 6emuB-6emvA:
33.0		 6emuB-6emvA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6et7 DIGUANYLATE CYCLASE
(GGDEF)
DOMAIN-CONTAINING
PROTEIN

(Idiomarina sp.
A28L) 		no annotation 5 ILE A 267
GLY A 268
ILE A 215
VAL A 244
ILE A 213
 None
 0.95A 6emuB-6et7A:
undetectable		 6emuB-6et7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6exn PRE-MRNA-SPLICING
FACTOR CWC2

(Saccharomyces
cerevisiae) 		no annotation 5 LEU M 204
GLY M 220
ILE M 156
ASP M 143
ILE M 142
 None
 1.07A 6emuB-6exnM:
undetectable		 6emuB-6exnM:
undetectable