SIMILAR PATTERNS OF AMINO ACIDS FOR 6EMU_A_SAMA501

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a5i PLASMINOGEN
ACTIVATOR

(Desmodus
rotundus) 		PF00089
(Trypsin) 		5 LEU A  53
ILE A  45
GLY A  44
ILE A 103
ILE A 212
 None
 0.98A 6emuA-1a5iA:
undetectable		 6emuA-1a5iA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1civ NADP-MALATE
DEHYDROGENASE

(Flaveria
bidentis) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		6 PRO A 323
GLY A 223
ILE A 348
VAL A 219
ASP A 232
ILE A 221
 None
 1.48A 6emuA-1civA:
2.0		 6emuA-1civA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ee6 PECTATE LYASE

(Bacillus sp.
KSM-P15) 		PF03211
(Pectate_lyase) 		5 ILE A 119
ILE A 169
ILE A 111
VAL A 141
ILE A 117
 None
 0.92A 6emuA-1ee6A:
undetectable		 6emuA-1ee6A:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hko CYTOCHROME B5

(Bos taurus) 		PF00173
(Cyt-b5) 		5 LEU A  83
GLY A  81
ILE A  79
ILE A  91
ILE A  28
 None
 0.92A 6emuA-1hkoA:
undetectable		 6emuA-1hkoA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hp1 5'-NUCLEOTIDASE

(Escherichia
coli) 		PF00149
(Metallophos)
PF02872
(5_nucleotid_C) 		5 LEU A 478
PRO A 484
ILE A 444
ILE A 480
ASP A 486
 None
 0.92A 6emuA-1hp1A:
undetectable		 6emuA-1hp1A:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ji6 PESTICIDIAL CRYSTAL
PROTEIN CRY3BB

(Bacillus
thuringiensis) 		PF00555
(Endotoxin_M)
PF03944
(Endotoxin_C)
PF03945
(Endotoxin_N) 		5 LEU A 580
ILE A 592
ILE A 642
VAL A 517
ILE A 570
 None
 0.99A 6emuA-1ji6A:
undetectable		 6emuA-1ji6A:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o5t TRYPTOPHANYL-TRNA
SYNTHETASE

(Homo sapiens) 		PF00579
(tRNA-synt_1b) 		6 ILE A 193
GLY A 161
ASP A 197
ILE A 223
VAL A 457
ILE A 234
 None
 1.39A 6emuA-1o5tA:
undetectable		 6emuA-1o5tA:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p1v SUPEROXIDE DISMUTASE
[CU-ZN]

(Homo sapiens) 		PF00080
(Sod_Cu) 		5 ILE A 149
GLY A 150
ILE A 151
ILE A 104
ILE A 112
 None
None
None
None
CSX  A 111 ( 4.0A)
 0.99A 6emuA-1p1vA:
undetectable		 6emuA-1p1vA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p1z LY49-C ANTIGEN

(Mus musculus) 		PF00059
(Lectin_C) 		5 LEU D 238
TRP D 163
ILE D 246
ILE D 180
ILE D 243
 None
 0.89A 6emuA-1p1zD:
undetectable		 6emuA-1p1zD:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pie GALACTOKINASE

(Lactococcus
lactis) 		PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C)
PF10509
(GalKase_gal_bdg) 		5 LEU A 136
ILE A  58
GLY A  59
ILE A  37
ILE A  56
 None
 1.00A 6emuA-1pieA:
undetectable		 6emuA-1pieA:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q50 GLUCOSE-6-PHOSPHATE
ISOMERASE

(Leishmania
mexicana) 		PF00342
(PGI) 		5 LEU A 298
GLY A 203
ILE A 204
VAL A 322
ILE A 332
 None
 1.01A 6emuA-1q50A:
undetectable		 6emuA-1q50A:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r6u TRYPTOPHANYL-TRNA
SYNTHETASE

(Homo sapiens) 		PF00579
(tRNA-synt_1b) 		6 ILE A 193
GLY A 161
ASP A 197
ILE A 223
VAL A 457
ILE A 234
 None
TYM  A 501 (-3.6A)
None
None
None
None
 1.43A 6emuA-1r6uA:
undetectable		 6emuA-1r6uA:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t0i YLR011WP

(Saccharomyces
cerevisiae) 		PF03358
(FMN_red) 		5 ILE A   5
GLY A   4
ILE A  88
ILE A 177
VAL A 151
 None
 0.99A 6emuA-1t0iA:
undetectable		 6emuA-1t0iA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t6k PHENAZINE
BIOSYNTHESIS PROTEIN
PHZF

(Pseudomonas
fluorescens) 		PF02567
(PhzC-PhzF) 		5 LEU A 134
ILE A 139
GLY A 138
ILE A 146
VAL A 156
 None
 0.88A 6emuA-1t6kA:
undetectable		 6emuA-1t6kA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tkk SIMILAR TO
CHLOROMUCONATE
CYCLOISOMERASE

(Bacillus
subtilis) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 LEU A 188
GLY A 214
ILE A 161
VAL A 163
ILE A 175
 None
 0.98A 6emuA-1tkkA:
undetectable		 6emuA-1tkkA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vi1 FATTY
ACID/PHOSPHOLIPID
SYNTHESIS PROTEIN
PLSX

(Bacillus
subtilis) 		PF02504
(FA_synthesis) 		5 ILE A  25
GLY A  24
ILE A 307
VAL A  55
ILE A  53
 None
 0.98A 6emuA-1vi1A:
4.5		 6emuA-1vi1A:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wa4 PCZA361.16

(Amycolatopsis
orientalis) 		PF00908
(dTDP_sugar_isom) 		6 ILE A  87
GLY A 119
ILE A 158
VAL A 123
ASP A  84
ILE A  85
 None
GOL  A1208 ( 4.4A)
None
None
None
None
 1.50A 6emuA-1wa4A:
undetectable		 6emuA-1wa4A:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xr6 GENOME POLYPROTEIN

(Rhinovirus A) 		PF00680
(RdRP_1) 		6 LEU A 225
PRO A 222
ILE A 323
ILE A 230
VAL A 370
ILE A 330
 None
 1.46A 6emuA-1xr6A:
undetectable		 6emuA-1xr6A:
16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y3n ALGQ1

(Sphingomonas
sp. A1) 		PF01547
(SBP_bac_1) 		5 LEU A  92
ILE A 124
ILE A 330
ASP A  97
ILE A  96
 None
 0.96A 6emuA-1y3nA:
undetectable		 6emuA-1y3nA:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ye8 HYPOTHETICAL UPF0334
KINASE-LIKE PROTEIN
AQ_1292

(Aquifex
aeolicus) 		PF03266
(NTPase_1) 		5 LEU A 169
THR A 161
ILE A  20
VAL A 134
ILE A 172
 None
 0.86A 6emuA-1ye8A:
undetectable		 6emuA-1ye8A:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a3j U1 SMALL NUCLEAR
RIBONUCLEOPROTEIN A

(Homo sapiens) 		PF00076
(RRM_1) 		5 ILE A  37
GLY A  73
ILE A  77
VAL A  32
ILE A  34
 None
 0.98A 6emuA-2a3jA:
undetectable		 6emuA-2a3jA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a9v GMP SYNTHASE

(Thermoplasma
acidophilum) 		PF00117
(GATase) 		5 PRO A  75
ILE A 184
GLY A 185
ASP A  44
ILE A   4
 None
 1.00A 6emuA-2a9vA:
undetectable		 6emuA-2a9vA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c4t 5'-FLUORO-5'-DEOXYAD
ENOSINE SYNTHASE

(Streptomyces
cattleya) 		PF01887
(SAM_adeno_trans) 		5 LEU A 225
ILE A 230
GLY A 229
ILE A 220
VAL A 195
 None
 0.94A 6emuA-2c4tA:
2.3		 6emuA-2c4tA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d1g ACID PHOSPHATASE

(Francisella
tularensis) 		PF04185
(Phosphoesterase) 		5 LEU A 243
ILE A 248
GLY A 247
ILE A 239
VAL A 452
 None
 0.97A 6emuA-2d1gA:
undetectable		 6emuA-2d1gA:
16.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e8y AMYX PROTEIN

(Bacillus
subtilis) 		PF00128
(Alpha-amylase)
PF02922
(CBM_48) 		5 LEU A 432
ILE A 460
GLY A 461
ILE A 518
VAL A 336
 None
 0.91A 6emuA-2e8yA:
undetectable		 6emuA-2e8yA:
14.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fko 173AA LONG
HYPOTHETICAL
FERRIPYOCHELIN
BINDING PROTEIN

(Pyrococcus
horikoshii) 		PF00132
(Hexapep) 		5 ILE A  97
GLY A  98
ILE A  99
ILE A  64
ILE A  80
 None
 1.00A 6emuA-2fkoA:
undetectable		 6emuA-2fkoA:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g85 CHORISMATE SYNTHASE

(Mycobacterium
tuberculosis) 		PF01264
(Chorismate_synt) 		5 ILE A  73
GLY A  62
ILE A  33
VAL A  57
ILE A  75
 None
 1.01A 6emuA-2g85A:
undetectable		 6emuA-2g85A:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gk3 PUTATIVE CYTOPLASMIC
PROTEIN

(Salmonella
enterica) 		PF07090
(GATase1_like) 		5 ILE A  80
ILE A 121
ASP A 223
ASP A  82
ILE A  83
 None
None
GOL  A1001 (-3.6A)
GOL  A1001 (-3.4A)
None
 0.83A 6emuA-2gk3A:
undetectable		 6emuA-2gk3A:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h5g DELTA
1-PYRROLINE-5-CARBOX
YLATE SYNTHETASE

(Homo sapiens) 		PF00171
(Aldedh) 		5 LEU A 554
ILE A 473
GLY A 474
ILE A 556
VAL A 490
 None
 1.01A 6emuA-2h5gA:
4.8		 6emuA-2h5gA:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ho9 CHEMOTAXIS PROTEIN
CHEW

(Escherichia
coli) 		PF01584
(CheW) 		6 LEU A  20
ILE A  31
GLY A  30
ILE A  39
VAL A  87
ILE A  89
 None
 1.09A 6emuA-2ho9A:
undetectable		 6emuA-2ho9A:
24.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hti BH0577 PROTEIN

(Bacillus
halodurans) 		PF12900
(Pyridox_ox_2) 		5 ILE A  62
GLY A  59
ILE A 103
VAL A  71
ILE A  65
 None
FAD  A 200 (-3.2A)
None
None
None
 0.97A 6emuA-2htiA:
undetectable		 6emuA-2htiA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i71 HYPOTHETICAL PROTEIN

(Sulfolobus
solfataricus) 		PF09455
(Cas_DxTHG) 		5 LEU A 114
ILE A 119
GLY A 118
VAL A  46
ILE A   4
 None
 0.89A 6emuA-2i71A:
undetectable		 6emuA-2i71A:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lu2 MICRONEME TGMIC5
PROTEIN

(Toxoplasma
gondii) 		no annotation 5 GLY A  91
THR A 109
ILE A 122
VAL A 129
ILE A 104
 None
 0.88A 6emuA-2lu2A:
undetectable		 6emuA-2lu2A:
24.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mbx PARVALBUMIN BETA

(Gadus morhua) 		PF13499
(EF-hand_7) 		5 ILE A  98
GLY A  99
ASP A  57
ASP A  52
ILE A  51
 None
None
None
CA  A 201 (-2.8A)
None
 0.95A 6emuA-2mbxA:
undetectable		 6emuA-2mbxA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mxz L-ALANYL-D-GLUTAMATE
PEPTIDASE

(Escherichia
virus T5) 		PF13539
(Peptidase_M15_4) 		5 PRO A  18
ILE A  41
GLY A  40
ILE A  72
ASP A  70
 None
 1.01A 6emuA-2mxzA:
undetectable		 6emuA-2mxzA:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o0o TNF SUPERFAMILY
LIGAND TL1A

(Homo sapiens) 		PF00229
(TNF) 		5 LEU A 195
GLY A 197
ILE A 212
ILE A 149
ILE A 181
 None
 0.96A 6emuA-2o0oA:
undetectable		 6emuA-2o0oA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2odl ADHESIN

(Haemophilus
influenzae) 		PF05860
(Haemagg_act) 		5 LEU A 234
ILE A 214
GLY A 215
ILE A 249
ILE A 239
 None
 0.99A 6emuA-2odlA:
undetectable		 6emuA-2odlA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pz0 GLYCEROPHOSPHORYL
DIESTER
PHOSPHODIESTERASE

(Caldanaerobacter
subterraneus) 		PF03009
(GDPD) 		5 LEU A 134
ILE A 130
GLY A 129
ILE A 149
ASP A 159
 None
 1.01A 6emuA-2pz0A:
undetectable		 6emuA-2pz0A:
26.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qua EXTRACELLULAR LIPASE

(Serratia
marcescens) 		no annotation 5 LEU A 390
GLY A 410
ASP A 376
ILE A 372
ILE A 381
 None
CA  A 618 (-4.6A)
None
None
None
 0.97A 6emuA-2quaA:
undetectable		 6emuA-2quaA:
15.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ral SERINE-ASPARTATE
REPEAT-CONTAINING
PROTEIN G

(Staphylococcus
epidermidis) 		PF10425
(SdrG_C_C) 		5 ILE A 346
GLY A 360
THR A 326
ILE A 331
ASP A 363
 None
 0.92A 6emuA-2ralA:
undetectable		 6emuA-2ralA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rck JUVENILE HORMONE
BINDING PROTEIN

(Galleria
mellonella) 		PF06585
(JHBP) 		5 LEU A  65
ILE A  46
ASP A  42
ILE A 118
ILE A 197
 None
 0.94A 6emuA-2rckA:
undetectable		 6emuA-2rckA:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rmc PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
C

(Mus musculus) 		PF00160
(Pro_isomerase) 		5 ILE A 148
GLY A 130
ILE A 129
ILE A 176
ILE A  96
 None
 1.00A 6emuA-2rmcA:
undetectable		 6emuA-2rmcA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uzz N-METHYL-L-TRYPTOPHA
N OXIDASE

(Escherichia
coli) 		PF01266
(DAO) 		5 LEU A 346
GLY A  14
ILE A   7
ILE A 320
ILE A 332
 None
 1.00A 6emuA-2uzzA:
2.1		 6emuA-2uzzA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v8p 4-DIPHOSPHOCYTIDYL-2
-C-METHYL-D-ERYTHRIT
OL KINASE

(Aquifex
aeolicus) 		PF00288
(GHMP_kinases_N) 		5 LEU A  30
ILE A 141
GLY A 142
ILE A 196
ILE A 193
 None
 0.97A 6emuA-2v8pA:
undetectable		 6emuA-2v8pA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wan PULLULANASE

(Bacillus
acidopullulyticus) 		PF00128
(Alpha-amylase)
PF02922
(CBM_48) 		5 LEU A 648
ILE A 676
GLY A 677
ILE A 729
VAL A 552
 None
 0.92A 6emuA-2wanA:
undetectable		 6emuA-2wanA:
11.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ycj 5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE

(Carboxydothermus
hydrogenoformans) 		PF00809
(Pterin_bind) 		5 ILE A  16
GLY A  11
ILE A  65
ASP A  44
ILE A   9
 None
None
None
C2F  A3000 ( 4.5A)
None
 0.90A 6emuA-2ycjA:
undetectable		 6emuA-2ycjA:
24.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z8z LIPASE

(Pseudomonas sp.
MIS38) 		PF00353
(HemolysinCabind) 		5 LEU A 389
GLY A 409
ASP A 375
ILE A 371
ILE A 380
 None
CA  A 622 (-4.6A)
None
None
None
 1.01A 6emuA-2z8zA:
undetectable		 6emuA-2z8zA:
14.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zci PHOSPHOENOLPYRUVATE
CARBOXYKINASE [GTP]

(Corynebacterium
glutamicum) 		PF00821
(PEPCK_C)
PF17297
(PEPCK_N) 		5 GLY A 223
ILE A 226
ILE A 236
VAL A 178
ILE A 214
 None
 0.94A 6emuA-2zciA:
undetectable		 6emuA-2zciA:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zuy YESX PROTEIN

(Bacillus
subtilis) 		PF01839
(FG-GAP) 		5 LEU A 172
GLY A 205
ILE A 213
ILE A 157
ASP A 208
 None
 0.99A 6emuA-2zuyA:
undetectable		 6emuA-2zuyA:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3af5 PUTATIVE
UNCHARACTERIZED
PROTEIN PH1404

(Pyrococcus
horikoshii) 		PF07521
(RMMBL)
PF10996
(Beta-Casp)
PF16661
(Lactamase_B_6)
PF17214
(KH_7) 		5 LEU A 458
ILE A 462
GLY A 460
ILE A 456
ILE A 519
 None
 0.86A 6emuA-3af5A:
undetectable		 6emuA-3af5A:
15.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aqi FERROCHELATASE

(Homo sapiens) 		PF00762
(Ferrochelatase) 		6 PRO A 131
TRP A 135
GLY A  77
THR A 136
ILE A 126
ILE A 342
 GOL  A 424 ( 4.8A)
None
None
None
None
None
 1.31A 6emuA-3aqiA:
3.4		 6emuA-3aqiA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3boh CADMIUM-SPECIFIC
CARBONIC ANHYDRASE

(Conticribra
weissflogii) 		no annotation 5 LEU A  51
GLY A  49
THR A  62
ILE A  73
VAL A 145
 None
 1.00A 6emuA-3bohA:
undetectable		 6emuA-3bohA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bsf AT4G34840

(Arabidopsis
thaliana) 		PF01048
(PNP_UDP_1) 		5 LEU A  59
ILE A  61
GLY A  54
ILE A  13
ILE A  16
 None
 1.00A 6emuA-3bsfA:
2.0		 6emuA-3bsfA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cc8 PUTATIVE
METHYLTRANSFERASE

(Bacillus cereus) 		PF13489
(Methyltransf_23) 		5 LEU A  25
ILE A 221
ILE A  49
VAL A  35
ILE A  28
 None
 0.94A 6emuA-3cc8A:
undetectable		 6emuA-3cc8A:
26.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dfz PRECORRIN-2
DEHYDROGENASE

(Bacillus
megaterium) 		PF13241
(NAD_binding_7)
PF14824
(Sirohm_synth_M) 		5 LEU A  30
GLY A  33
ILE A  26
VAL A  15
ILE A  36
 None
 0.78A 6emuA-3dfzA:
3.1		 6emuA-3dfzA:
25.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dh4 SODIUM/GLUCOSE
COTRANSPORTER

(Vibrio
parahaemolyticus) 		PF00474
(SSF) 		5 LEU A 303
PRO A 298
ILE A 306
GLY A  77
ILE A  84
 None
 1.01A 6emuA-3dh4A:
undetectable		 6emuA-3dh4A:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dnf 4-HYDROXY-3-METHYLBU
T-2-ENYL DIPHOSPHATE
REDUCTASE

(Aquifex
aeolicus) 		PF02401
(LYTB) 		5 ILE A 142
GLY A 141
THR A 110
ILE A 179
VAL A 183
 None
 0.98A 6emuA-3dnfA:
undetectable		 6emuA-3dnfA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3doc GLYCERALDEHYDE
3-PHOSPHATE
DEHYDROGENASE

(Brucella
abortus) 		PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C) 		6 ILE A   7
GLY A  14
ILE A  67
VAL A  40
ASP A  36
ILE A  34
 None
None
None
None
NAD  A 901 (-3.6A)
None
 1.40A 6emuA-3docA:
3.3		 6emuA-3docA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e81 ACYLNEURAMINATE
CYTIDYLYLTRANSFERASE

(Bacteroides
thetaiotaomicron) 		PF08282
(Hydrolase_3) 		6 LEU A 130
GLY A 118
ILE A 101
THR A   9
ASP A 103
ILE A 127
 None
None
None
None
MG  A 165 (-2.6A)
None
 1.45A 6emuA-3e81A:
2.2		 6emuA-3e81A:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ejb BIOTIN BIOSYNTHESIS
CYTOCHROME P450-LIKE
ENZYME

(Bacillus
subtilis) 		PF00067
(p450) 		5 LEU B 352
ILE B 143
ILE B 356
VAL B 115
ILE B 111
 None
 1.01A 6emuA-3ejbB:
undetectable		 6emuA-3ejbB:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3en0 CYANOPHYCINASE

(Synechocystis
sp. PCC 6803) 		PF03575
(Peptidase_S51) 		5 ILE A  12
GLY A  14
ILE A 216
ASP A  17
ILE A  24
 None
 0.97A 6emuA-3en0A:
undetectable		 6emuA-3en0A:
26.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3etc AMP-BINDING PROTEIN

(Methanosarcina
acetivorans) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		5 LEU A 228
ILE A  26
THR A 355
ILE A 267
ILE A 231
 None
GOL  A1002 (-4.2A)
None
None
None
 0.97A 6emuA-3etcA:
undetectable		 6emuA-3etcA:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fd0 PUTATIVE
CYSTATHIONINE
BETA-LYASE INVOLVED
IN ALUMINUM
RESISTANCE

(Listeria
innocua) 		PF06838
(Met_gamma_lyase) 		5 GLY A 144
ILE A 106
VAL A 151
ASP A 147
ILE A 146
 None
None
None
None
EDO  A 413 (-4.3A)
 0.80A 6emuA-3fd0A:
undetectable		 6emuA-3fd0A:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fdx PUTATIVE FILAMENT
PROTEIN / UNIVERSAL
STRESS PROTEIN F

(Klebsiella
pneumoniae) 		PF00582
(Usp) 		5 ILE A   2
ILE A  27
ILE A  17
VAL A 140
ILE A 109
 None
 1.01A 6emuA-3fdxA:
4.1		 6emuA-3fdxA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h0g DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB1
DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB2

(Schizosaccharomyces
pombe;
Schizosaccharomyces
pombe) 		PF00623
(RNA_pol_Rpb1_2)
PF04983
(RNA_pol_Rpb1_3)
PF04990
(RNA_pol_Rpb1_7)
PF04992
(RNA_pol_Rpb1_6)
PF04997
(RNA_pol_Rpb1_1)
PF04998
(RNA_pol_Rpb1_5)
PF05000
(RNA_pol_Rpb1_4)
PF00562
(RNA_pol_Rpb2_6)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF04566
(RNA_pol_Rpb2_4)
PF04567
(RNA_pol_Rpb2_5) 		5 ILE A 670
ILE A 672
ILE B1001
VAL B 814
ILE B 816
 None
 0.99A 6emuA-3h0gA:
undetectable		 6emuA-3h0gA:
9.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hc7 GENE 12 PROTEIN

(Mycobacterium
virus D29) 		PF01083
(Cutinase) 		5 LEU A 218
ILE A 212
ILE A 222
VAL A 187
ILE A 183
 None
 1.01A 6emuA-3hc7A:
undetectable		 6emuA-3hc7A:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hij DIHYDRODIPICOLINATE
SYNTHASE

(Bacillus
anthracis) 		PF00701
(DHDPS) 		5 GLY A 188
ILE A 204
THR A 193
ILE A 175
ILE A 162
 KPI  A 163 ( 3.9A)
None
None
None
KPI  A 163 ( 3.7A)
 0.97A 6emuA-3hijA:
2.7		 6emuA-3hijA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i12 D-ALANINE-D-ALANINE
LIGASE A

(Salmonella
enterica) 		PF01820
(Dala_Dala_lig_N)
PF07478
(Dala_Dala_lig_C) 		6 PRO A 126
ILE A 347
THR A 355
ILE A 102
VAL A  99
ASP A 100
 None
 1.21A 6emuA-3i12A:
2.7		 6emuA-3i12A:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i16 ALUMINUM RESISTANCE
PROTEIN

(Clostridium
novyi) 		PF06838
(Met_gamma_lyase) 		5 ILE A 417
GLY A 416
ILE A 419
THR A 353
ILE A 336
 None
 0.87A 6emuA-3i16A:
undetectable		 6emuA-3i16A:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i1e LIN2157 PROTEIN

(Listeria
innocua) 		PF13180
(PDZ_2) 		5 LEU A  19
ILE A  18
GLY A  17
ILE A  80
ILE A  67
 None
 1.00A 6emuA-3i1eA:
undetectable		 6emuA-3i1eA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i7f ASPARTYL-TRNA
SYNTHETASE

(Entamoeba
histolytica) 		PF00152
(tRNA-synt_2)
PF01336
(tRNA_anti-codon) 		5 LEU A 369
ILE A 372
ILE A  85
ILE A 361
ILE A 242
 None
 0.93A 6emuA-3i7fA:
undetectable		 6emuA-3i7fA:
15.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3icl EAL/GGDEF DOMAIN
PROTEIN

(Methylococcus
capsulatus) 		PF00990
(GGDEF) 		5 LEU A  35
ILE A 122
GLY A 123
ILE A  63
VAL A  67
 None
 0.93A 6emuA-3iclA:
undetectable		 6emuA-3iclA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ijd UNCHARACTERIZED
PROTEIN

(Ruminiclostridium
thermocellum) 		PF02219
(MTHFR) 		5 GLY A  48
ILE A  88
ILE A 299
ASP A  45
ILE A  14
 None
 1.00A 6emuA-3ijdA:
3.2		 6emuA-3ijdA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jav INOSITOL
1,4,5-TRISPHOSPHATE
RECEPTOR TYPE 1

(Rattus
norvegicus) 		PF00520
(Ion_trans)
PF01365
(RYDR_ITPR)
PF02815
(MIR)
PF08454
(RIH_assoc)
PF08709
(Ins145_P3_rec) 		5 LEU A  60
PRO A  62
GLY A  12
ILE A 121
ILE A 115
 None
 0.99A 6emuA-3javA:
undetectable		 6emuA-3javA:
5.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k6j PROTEIN F01G10.3,
CONFIRMED BY
TRANSCRIPT EVIDENCE

(Caenorhabditis
elegans) 		PF00725
(3HCDH)
PF02737
(3HCDH_N) 		5 LEU A 376
GLY A 379
VAL A 212
ASP A 371
ILE A 375
 None
 0.98A 6emuA-3k6jA:
undetectable		 6emuA-3k6jA:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k8a PUTATIVE PRIMOSOMAL
REPLICATION PROTEIN

(Neisseria
gonorrhoeae) 		no annotation 6 LEU A  29
GLY A  58
ILE A  26
THR A  22
ILE A  31
ILE A  56
 None
 1.42A 6emuA-3k8aA:
undetectable		 6emuA-3k8aA:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ki8 BETA
UREIDOPROPIONASE
(BETA-ALANINE
SYNTHASE)

(Pyrococcus
abyssi) 		PF00795
(CN_hydrolase) 		5 GLY A  86
THR A  46
ILE A  27
VAL A  75
ILE A  83
 None
 0.92A 6emuA-3ki8A:
undetectable		 6emuA-3ki8A:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nd0 SLL0855 PROTEIN

(Synechocystis
sp. PCC 6803) 		PF00654
(Voltage_CLC) 		5 PRO A 106
GLY A 347
ILE A 348
ILE A 108
ILE A 148
 None
CL  A 467 ( 3.9A)
CL  A 467 (-4.6A)
None
None
 0.99A 6emuA-3nd0A:
undetectable		 6emuA-3nd0A:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o21 GLUTAMATE RECEPTOR 3

(Rattus
norvegicus) 		PF01094
(ANF_receptor) 		5 LEU A 219
ILE A 227
GLY A 223
ILE A 191
ILE A 198
 None
 1.02A 6emuA-3o21A:
undetectable		 6emuA-3o21A:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3odg XANTHOSINE
PHOSPHORYLASE

(Yersinia
pseudotuberculosis) 		PF01048
(PNP_UDP_1) 		5 LEU A  77
GLY A  75
ILE A  25
ASP A  61
ILE A  62
 None
 0.91A 6emuA-3odgA:
undetectable		 6emuA-3odgA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3odm PHOSPHOENOLPYRUVATE
CARBOXYLASE

(Clostridium
perfringens) 		PF14010
(PEPcase_2) 		6 ILE A 234
GLY A 227
ASP A 178
ILE A 198
VAL A 164
ILE A 196
 None
 1.46A 6emuA-3odmA:
2.4		 6emuA-3odmA:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3plr UDP-GLUCOSE
6-DEHYDROGENASE

(Klebsiella
pneumoniae) 		PF00984
(UDPG_MGDP_dh)
PF03720
(UDPG_MGDP_dh_C)
PF03721
(UDPG_MGDP_dh_N) 		5 ILE A 318
ILE A 334
ILE A 291
VAL A 362
ILE A 364
 None
 1.01A 6emuA-3plrA:
2.2		 6emuA-3plrA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u62 SHIKIMATE
DEHYDROGENASE

(Thermotoga
maritima) 		PF01488
(Shikimate_DH)
PF08501
(Shikimate_dh_N) 		5 LEU A 128
GLY A 131
ILE A 124
VAL A 113
ILE A 135
 None
 1.00A 6emuA-3u62A:
3.4		 6emuA-3u62A:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ue3 SEPTUM FORMATION,
PENICILLIN BINDING
PROTEIN 3,
PEPTIDOGLYCAN
SYNTHETASE

(Acinetobacter
sp. ATCC 27244) 		PF00905
(Transpeptidase)
PF03717
(PBP_dimer) 		5 LEU A 219
ILE A 206
GLY A 207
ILE A 260
ILE A  79
 None
 0.94A 6emuA-3ue3A:
undetectable		 6emuA-3ue3A:
17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uk8 CADMIUM-SPECIFIC
CARBONIC ANHYDRASE

(Conticribra
weissflogii) 		no annotation 5 LEU A 471
GLY A 469
THR A 482
ILE A 493
VAL A 565
 None
 1.01A 6emuA-3uk8A:
undetectable		 6emuA-3uk8A:
27.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3upy OXIDOREDUCTASE

(Brucella
abortus) 		PF03447
(NAD_binding_3) 		5 ILE A  29
GLY A  30
THR A  36
ILE A 108
ILE A 102
 None
 0.97A 6emuA-3upyA:
3.8		 6emuA-3upyA:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vrb FLAVOPROTEIN SUBUNIT
OF COMPLEX II

(Ascaris suum) 		PF00890
(FAD_binding_2)
PF02910
(Succ_DH_flav_C) 		5 ILE A 280
GLY A 284
THR A 248
ILE A 363
ILE A 287
 None
None
FAD  A 702 ( 4.9A)
None
None
 0.95A 6emuA-3vrbA:
2.1		 6emuA-3vrbA:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vti HYDROGENASE
MATURATION FACTOR

(Caldanaerobacter
subterraneus) 		PF00586
(AIRS)
PF02769
(AIRS_C) 		5 LEU C 123
PRO C 119
ILE C 126
ILE C 114
ILE C 157
 None
 0.97A 6emuA-3vtiC:
undetectable		 6emuA-3vtiC:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wdq BETA-MANNANASE

(Symbiotic
protist of
Reticulitermes
speratus) 		PF02156
(Glyco_hydro_26) 		6 LEU A  79
PRO A  77
ILE A 118
GLY A 117
ASP A 339
ILE A  48
 None
 1.39A 6emuA-3wdqA:
undetectable		 6emuA-3wdqA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wgh REDOX-SENSING
TRANSCRIPTIONAL
REPRESSOR REX

(Thermoanaerobacter
ethanolicus) 		PF02629
(CoA_binding)
PF06971
(Put_DNA-bind_N) 		6 ILE A  89
GLY A  91
ILE A 154
THR A 162
ILE A 149
ILE A 151
 None
NAI  A 301 ( 3.7A)
NAI  A 301 (-3.7A)
NAI  A 301 (-3.7A)
None
None
 1.41A 6emuA-3wghA:
3.8		 6emuA-3wghA:
23.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zm8 GH26
ENDO-BETA-1,4-MANNAN
ASE

(Podospora
anserina) 		PF02156
(Glyco_hydro_26)
PF16990
(CBM_35) 		5 LEU A 189
ILE A 223
GLY A 222
ASP A 442
ILE A 167
 None
 0.95A 6emuA-3zm8A:
undetectable		 6emuA-3zm8A:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zuq BOTULINUM NEUROTOXIN
TYPE B

(Clostridium
botulinum) 		PF01742
(Peptidase_M27)
PF07952
(Toxin_trans) 		6 LEU A 758
ILE A 799
GLY A 798
ILE A 806
ASP A 804
ILE A 803
 None
 1.48A 6emuA-3zuqA:
undetectable		 6emuA-3zuqA:
11.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aee ALPHA AMYLASE,
CATALYTIC REGION

(Staphylothermus
marinus) 		PF00128
(Alpha-amylase) 		6 LEU A 264
ILE A 267
GLY A 266
ILE A 287
ASP A 234
ILE A 233
 None
 1.21A 6emuA-4aeeA:
2.6		 6emuA-4aeeA:
14.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c8q DNA TOPOISOMERASE
2-ASSOCIATED PROTEIN
PAT1

(Saccharomyces
cerevisiae) 		PF09770
(PAT1) 		5 ILE H 533
GLY H 532
ILE H 535
ILE H 555
ILE H 591
 None
 0.96A 6emuA-4c8qH:
undetectable		 6emuA-4c8qH:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ccs CBIX

(Paracoccus
pantotrophus) 		PF01903
(CbiX) 		5 LEU A  62
PRO A  61
GLY A  93
THR A  66
ILE A   7
 None
 1.01A 6emuA-4ccsA:
undetectable		 6emuA-4ccsA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cr2 26S PROTEASE
REGULATORY SUBUNIT 4
HOMOLOG

(Saccharomyces
cerevisiae) 		PF00004
(AAA) 		5 LEU I 109
GLY I 107
ILE I 106
VAL I 136
ILE I 156
 None
 0.97A 6emuA-4cr2I:
undetectable		 6emuA-4cr2I:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dpk MALONYL-COA/SUCCINYL
-COA REDUCTASE

(Sulfurisphaera
tokodaii) 		PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC) 		5 LEU A  13
GLY A  40
ILE A  69
ILE A  83
VAL A  80
 None
PO4  A 401 (-3.3A)
PO4  A 401 (-4.2A)
None
None
 1.01A 6emuA-4dpkA:
4.2		 6emuA-4dpkA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e51 HISTIDINE--TRNA
LIGASE

(Burkholderia
thailandensis) 		PF03129
(HGTP_anticodon)
PF13393
(tRNA-synt_His) 		5 LEU A 267
ILE A  62
GLY A  63
ASP A  67
ILE A  68
 None
 1.01A 6emuA-4e51A:
undetectable		 6emuA-4e51A:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eex ALCOHOL
DEHYDROGENASE 1

(Lactococcus
lactis) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 GLY A 216
ILE A 196
ILE A 224
VAL A 168
ILE A 213
 None
 1.01A 6emuA-4eexA:
3.0		 6emuA-4eexA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ew9 PECTATE LYASE

(Caldicellulosiruptor
bescii) 		PF03211
(Pectate_lyase) 		5 LEU A   6
ILE A  25
GLY A   4
ILE A   8
ILE A  27
 MPD  A 207 ( 3.8A)
MPD  A 207 ( 4.8A)
None
MPD  A 206 (-4.4A)
None
 0.94A 6emuA-4ew9A:
undetectable		 6emuA-4ew9A:
22.87