SIMILAR PATTERNS OF AMINO ACIDS FOR 6EMM_A_SALA303

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hr7 MITOCHONDRIAL
PROCESSING PEPTIDASE
BETA SUBUNIT

(Saccharomyces
cerevisiae) 		PF00675
(Peptidase_M16)
PF05193
(Peptidase_M16_C) 		5 SER B 329
VAL B 275
TYR B 282
LEU B 384
LEU B 380
 None
 1.28A 6emmA-1hr7B:
0.5		 6emmA-1hr7B:
10.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z3k LEUCYL/PHENYLALANYL-
TRNA-PROTEIN
TRANSFERASE

(Escherichia
coli) 		PF03588
(Leu_Phe_trans) 		5 HIS A 193
SER A 160
ASN A 164
LEU A 170
LEU A 197
 XYA  A 301 ( 4.2A)
TAR  A 501 ( 2.6A)
TAR  A 501 ( 4.6A)
None
None
 1.38A 6emmA-2z3kA:
0.0		 6emmA-2z3kA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q75 FARNESYLTRANSFERASE
BETA SUBUNIT

(Cryptococcus
neoformans) 		PF00432
(Prenyltrans) 		5 HIS B  66
GLN B 389
ASN B 492
LEU B 102
LEU B 415
 None
 1.05A 6emmA-3q75B:
0.0		 6emmA-3q75B:
10.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d8u D-CYSTEINE
DESULFHYDRASE

(Salmonella
enterica) 		PF00291
(PALP) 		5 HIS A  80
SER A 195
ASN A  50
LEU A  58
LEU A  55
 LLP  A  51 (-4.8A)
LLP  A  51 ( 2.4A)
LLP  A  51 ( 3.1A)
None
LLP  A  51 ( 3.7A)
 1.45A 6emmA-4d8uA:
2.7		 6emmA-4d8uA:
17.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d2j 4-OXALOCROTONATE
DECARBOXYLASE NAHK

(Pseudomonas
putida) 		no annotation 5 VAL A 159
GLN A  46
TYR A  43
LEU A 215
LEU A  63
 None
None
EDO  A 304 (-3.7A)
None
EDO  A 305 ( 4.4A)
 1.23A 6emmA-5d2jA:
0.0		 6emmA-5d2jA:
16.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5en4 17-BETA-HYDROXYSTERO
ID DEHYDROGENASE 14

(Homo sapiens) 		PF13561
(adh_short_C2) 		9 HIS A  93
SER A 141
VAL A 143
GLN A 148
TYR A 154
ASN A 186
LEU A 191
TRP A 192
LEU A 195
 5Q6  A 302 (-3.5A)
5Q6  A 302 ( 2.4A)
5Q6  A 302 ( 4.7A)
5Q6  A 302 (-3.6A)
5Q6  A 302 ( 4.3A)
5Q6  A 302 (-4.4A)
NAD  A 301 (-3.6A)
5Q6  A 302 ( 3.3A)
5Q6  A 302 (-4.1A)
 0.23A 6emmA-5en4A:
44.3		 6emmA-5en4A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wmb DNA REPAIR PROTEIN
REV1

(Saccharomyces
cerevisiae) 		no annotation 5 VAL A 391
TYR A 436
ASN A 414
LEU A 325
LEU A 328
 None
None
DCP  A 804 (-3.4A)
None
DCP  A 804 (-4.6A)
 1.34A 6emmA-5wmbA:
0.0		 6emmA-5wmbA:
11.17