SIMILAR PATTERNS OF AMINO ACIDS FOR 6ELI_A_T27A701

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1axd GLUTATHIONE
S-TRANSFERASE I

(Zea mays) 		PF00043
(GST_C)
PF02798
(GST_N) 		5 PRO A  55
LEU A   5
VAL A 206
VAL A   9
TYR A  28
 None
 1.46A 6eliA-1axdA:
0.0		 6eliA-1axdA:
15.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fuk EUKARYOTIC
INITIATION FACTOR 4A

(Saccharomyces
cerevisiae) 		PF00271
(Helicase_C) 		5 LEU A 253
VAL A 358
VAL A 259
PHE A 236
LEU A 385
 None
 1.42A 6eliA-1fukA:
undetectable		 6eliA-1fukA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gr0 INOSITOL-3-PHOSPHATE
SYNTHASE

(Mycobacterium
tuberculosis) 		PF01658
(Inos-1-P_synth) 		5 LEU A 344
VAL A 337
VAL A 169
PHE A 364
LEU A 361
 None
 1.22A 6eliA-1gr0A:
0.0		 6eliA-1gr0A:
14.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i4g ENTEROTOXIN TYPE A

(Staphylococcus
aureus) 		PF01123
(Stap_Strp_toxin)
PF02876
(Stap_Strp_tox_C) 		5 LEU A 169
LYS A  15
TYR A 231
LEU A 198
TYR A 170
 None
 1.20A 6eliA-1i4gA:
undetectable		 6eliA-1i4gA:
15.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j2b ARCHAEOSINE
TRNA-GUANINE
TRANSGLYCOSYLASE

(Pyrococcus
horikoshii) 		PF01472
(PUA)
PF01702
(TGT)
PF14809
(TGT_C1)
PF14810
(TGT_C2) 		5 PRO A 379
LYS A 365
PHE A 369
LEU A 368
TYR A 415
 None
 1.28A 6eliA-1j2bA:
2.1		 6eliA-1j2bA:
9.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1mu2 HIV-2 RT

(Human
immunodeficiency
virus 2) 		PF00075
(RNase_H)
PF00078
(RVT_1)
PF06815
(RVT_connect)
PF06817
(RVT_thumb) 		5 LEU A 100
LYS A 103
TRP A 229
LEU A 234
TYR A 318
 None
 1.10A 6eliA-1mu2A:
29.1		 6eliA-1mu2A:
61.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1mu2 HIV-2 RT

(Human
immunodeficiency
virus 2) 		PF00075
(RNase_H)
PF00078
(RVT_1)
PF06815
(RVT_connect)
PF06817
(RVT_thumb) 		5 LEU A 100
PRO A 225
TRP A 229
LEU A 234
TYR A 318
 None
 0.98A 6eliA-1mu2A:
29.1		 6eliA-1mu2A:
61.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1mu2 HIV-2 RT

(Human
immunodeficiency
virus 2) 		PF00075
(RNase_H)
PF00078
(RVT_1)
PF06815
(RVT_connect)
PF06817
(RVT_thumb) 		5 PRO A  95
LYS A 103
TRP A 229
LEU A 234
TYR A 318
 None
 1.01A 6eliA-1mu2A:
29.1		 6eliA-1mu2A:
61.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ope SUCCINYL-COA:3-KETOA
CID-COENZYME A
TRANSFERASE

(Sus scrofa) 		PF01144
(CoA_trans) 		5 PRO A  15
LEU A  46
VAL A  22
PRO A  31
LEU A  38
 None
 1.30A 6eliA-1opeA:
0.0		 6eliA-1opeA:
11.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ox8 STRINGENT STARVATION
PROTEIN B

(Escherichia
coli) 		PF04386
(SspB) 		5 LEU A  65
VAL A  90
PHE A  72
LEU A  63
TYR A  18
 None
 1.43A 6eliA-1ox8A:
undetectable		 6eliA-1ox8A:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uou THYMIDINE
PHOSPHORYLASE

(Homo sapiens) 		PF00591
(Glycos_transf_3)
PF02885
(Glycos_trans_3N)
PF07831
(PYNP_C) 		5 LEU A 476
VAL A 256
VAL A 232
PRO A 480
LEU A 478
 None
 1.20A 6eliA-1uouA:
1.3		 6eliA-1uouA:
8.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uwy CARBOXYPEPTIDASE M

(Homo sapiens) 		PF00246
(Peptidase_M14)
PF13620
(CarboxypepD_reg) 		5 VAL A 167
PRO A 182
PHE A 205
LEU A 208
TYR A 290
 None
 1.39A 6eliA-1uwyA:
undetectable		 6eliA-1uwyA:
12.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v9a UROPORPHYRIN-III
C-METHYLTRANSFERASE

(Thermus
thermophilus) 		PF00590
(TP_methylase) 		5 LEU A  17
VAL A   7
PRO A  46
LEU A  44
TYR A  22
 None
 1.25A 6eliA-1v9aA:
undetectable		 6eliA-1v9aA:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wpx CARBOXYPEPTIDASE Y
INHIBITOR

(Saccharomyces
cerevisiae) 		PF01161
(PBP) 		5 PRO B 532
LEU B 708
VAL B 524
TYR B 515
TYR B 668
 None
 1.39A 6eliA-1wpxB:
undetectable		 6eliA-1wpxB:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z6t APOPTOTIC PROTEASE
ACTIVATING FACTOR 1

(Homo sapiens) 		PF00619
(CARD)
PF00931
(NB-ARC) 		5 LEU A 386
TYR A 436
PHE A 425
LEU A 424
TYR A 383
 None
None
ADP  A 900 (-3.8A)
None
None
 1.24A 6eliA-1z6tA:
undetectable		 6eliA-1z6tA:
7.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z8l GLUTAMATE
CARBOXYPEPTIDASE II

(Homo sapiens) 		PF02225
(PA)
PF04253
(TFR_dimer)
PF04389
(Peptidase_M28) 		5 PRO A 243
VAL A 154
TYR A 151
PRO A  81
PHE A 383
 None
 1.44A 6eliA-1z8lA:
undetectable		 6eliA-1z8lA:
9.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z9l VESICLE-ASSOCIATED
MEMBRANE
PROTEIN-ASSOCIATED
PROTEIN A

(Rattus
norvegicus) 		PF00635
(Motile_Sperm) 		5 LEU A 119
VAL A  71
VAL A  44
TYR A  52
PHE A  18
 None
 1.40A 6eliA-1z9lA:
undetectable		 6eliA-1z9lA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b5i CYTOKINE RECEPTOR
COMMON GAMMA CHAIN

(Homo sapiens) 		PF00041
(fn3)
PF09240
(IL6Ra-bind) 		5 LEU C 140
VAL C 165
TYR C 197
TYR C 167
PHE C 186
 None
 1.45A 6eliA-2b5iC:
undetectable		 6eliA-2b5iC:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bbv PROTEIN (BLACK
BEETLE VIRUS CAPSID
PROTEIN)

(Black beetle
virus) 		PF01829
(Peptidase_A6) 		5 LEU A 217
VAL A 223
PRO A 134
PHE A 140
TRP A 124
 None
 1.44A 6eliA-2bbvA:
undetectable		 6eliA-2bbvA:
11.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bra NEDD9 INTERACTING
PROTEIN WITH
CALPONIN HOMOLOGY
AND LIM DOMAINS

(Mus musculus) 		PF01494
(FAD_binding_3) 		5 LEU A  97
VAL A 173
VAL A  89
TRP A 177
LEU A 165
 None
 1.46A 6eliA-2braA:
2.4		 6eliA-2braA:
12.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ch6 N-ACETYL-D-GLUCOSAMI
NE KINASE

(Homo sapiens) 		PF01869
(BcrAD_BadFG) 		5 LEU A  71
VAL A  46
PHE A  95
LEU A  98
TYR A 102
 None
 1.25A 6eliA-2ch6A:
4.5		 6eliA-2ch6A:
11.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2csw UBIQUITIN LIGASE
PROTEIN RNF8

(Homo sapiens) 		PF00498
(FHA) 		5 LEU A 108
VAL A  46
VAL A  65
TYR A  48
LEU A  50
 None
 1.42A 6eliA-2cswA:
undetectable		 6eliA-2cswA:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e21 TRNA(ILE)-LYSIDINE
SYNTHASE

(Aquifex
aeolicus) 		PF01171
(ATP_bind_3) 		5 LEU A  40
VAL A  11
VAL A 172
PHE A  51
LEU A  44
 None
 1.40A 6eliA-2e21A:
undetectable		 6eliA-2e21A:
14.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2elc ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE

(Thermus
thermophilus) 		PF00591
(Glycos_transf_3)
PF02885
(Glycos_trans_3N) 		5 PRO A 242
LEU A 240
VAL A 189
LEU A 300
TYR A 238
 None
 1.33A 6eliA-2elcA:
undetectable		 6eliA-2elcA:
13.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2erj CYTOKINE RECEPTOR
COMMON GAMMA CHAIN

(Homo sapiens) 		PF00041
(fn3)
PF09240
(IL6Ra-bind) 		5 LEU C 140
VAL C 165
TYR C 197
TYR C 167
PHE C 186
 None
 1.36A 6eliA-2erjC:
undetectable		 6eliA-2erjC:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f5u VIRION PROTEIN UL25

(Human
alphaherpesvirus
1) 		PF01499
(Herpes_UL25) 		5 PRO A 574
LEU A 406
VAL A 416
PRO A 145
TYR A 562
 None
 1.36A 6eliA-2f5uA:
undetectable		 6eliA-2f5uA:
12.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gqc RHOMBOID
INTRAMEMBRANE
PROTEASE

(Pseudomonas
aeruginosa) 		PF16733
(NRho) 		5 PRO A  10
VAL A  42
VAL A   6
PRO A  28
LEU A  22
 None
 1.49A 6eliA-2gqcA:
undetectable		 6eliA-2gqcA:
20.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hnz REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H

(Human
immunodeficiency
virus 1) 		PF00075
(RNase_H)
PF00078
(RVT_1)
PF06815
(RVT_connect)
PF06817
(RVT_thumb) 		8 LEU A 100
LYS A 103
VAL A 106
TYR A 181
TYR A 188
PRO A 225
LEU A 234
TYR A 318
 PC0  A 999 ( 3.9A)
None
PC0  A 999 ( 4.8A)
PC0  A 999 (-3.9A)
PC0  A 999 (-4.1A)
None
PC0  A 999 (-4.2A)
PC0  A 999 (-4.3A)
 0.80A 6eliA-2hnzA:
36.5		 6eliA-2hnzA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hnz REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H

(Human
immunodeficiency
virus 1) 		PF00075
(RNase_H)
PF00078
(RVT_1)
PF06815
(RVT_connect)
PF06817
(RVT_thumb) 		8 LEU A 100
LYS A 103
VAL A 106
TYR A 188
PRO A 225
PHE A 227
LEU A 234
TYR A 318
 PC0  A 999 ( 3.9A)
None
PC0  A 999 ( 4.8A)
PC0  A 999 (-4.1A)
None
PC0  A 999 (-4.7A)
PC0  A 999 (-4.2A)
PC0  A 999 (-4.3A)
 0.84A 6eliA-2hnzA:
36.5		 6eliA-2hnzA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hnz REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H

(Human
immunodeficiency
virus 1) 		PF00075
(RNase_H)
PF00078
(RVT_1)
PF06815
(RVT_connect)
PF06817
(RVT_thumb) 		8 LEU A 100
VAL A 106
VAL A 179
TYR A 181
TYR A 188
PRO A 225
LEU A 234
TYR A 318
 PC0  A 999 ( 3.9A)
PC0  A 999 ( 4.8A)
PC0  A 999 (-4.4A)
PC0  A 999 (-3.9A)
PC0  A 999 (-4.1A)
None
PC0  A 999 (-4.2A)
PC0  A 999 (-4.3A)
 0.80A 6eliA-2hnzA:
36.5		 6eliA-2hnzA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hnz REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H

(Human
immunodeficiency
virus 1) 		PF00075
(RNase_H)
PF00078
(RVT_1)
PF06815
(RVT_connect)
PF06817
(RVT_thumb) 		8 LEU A 100
VAL A 106
VAL A 179
TYR A 188
PRO A 225
PHE A 227
LEU A 234
TYR A 318
 PC0  A 999 ( 3.9A)
PC0  A 999 ( 4.8A)
PC0  A 999 (-4.4A)
PC0  A 999 (-4.1A)
None
PC0  A 999 (-4.7A)
PC0  A 999 (-4.2A)
PC0  A 999 (-4.3A)
 0.85A 6eliA-2hnzA:
36.5		 6eliA-2hnzA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hnz REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H

(Human
immunodeficiency
virus 1) 		PF00075
(RNase_H)
PF00078
(RVT_1)
PF06815
(RVT_connect)
PF06817
(RVT_thumb) 		9 PRO A  95
LEU A 100
LYS A 103
VAL A 106
PRO A 225
PHE A 227
TRP A 229
LEU A 234
TYR A 318
 PC0  A 999 ( 4.9A)
PC0  A 999 ( 3.9A)
None
PC0  A 999 ( 4.8A)
None
PC0  A 999 (-4.7A)
PC0  A 999 ( 4.2A)
PC0  A 999 (-4.2A)
PC0  A 999 (-4.3A)
 0.68A 6eliA-2hnzA:
36.5		 6eliA-2hnzA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hnz REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H

(Human
immunodeficiency
virus 1) 		PF00075
(RNase_H)
PF00078
(RVT_1)
PF06815
(RVT_connect)
PF06817
(RVT_thumb) 		9 PRO A  95
LEU A 100
LYS A 103
VAL A 106
TYR A 181
PRO A 225
TRP A 229
LEU A 234
TYR A 318
 PC0  A 999 ( 4.9A)
PC0  A 999 ( 3.9A)
None
PC0  A 999 ( 4.8A)
PC0  A 999 (-3.9A)
None
PC0  A 999 ( 4.2A)
PC0  A 999 (-4.2A)
PC0  A 999 (-4.3A)
 0.76A 6eliA-2hnzA:
36.5		 6eliA-2hnzA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hnz REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H

(Human
immunodeficiency
virus 1) 		PF00075
(RNase_H)
PF00078
(RVT_1)
PF06815
(RVT_connect)
PF06817
(RVT_thumb) 		9 PRO A  95
LEU A 100
VAL A 106
VAL A 179
PRO A 225
PHE A 227
TRP A 229
LEU A 234
TYR A 318
 PC0  A 999 ( 4.9A)
PC0  A 999 ( 3.9A)
PC0  A 999 ( 4.8A)
PC0  A 999 (-4.4A)
None
PC0  A 999 (-4.7A)
PC0  A 999 ( 4.2A)
PC0  A 999 (-4.2A)
PC0  A 999 (-4.3A)
 0.68A 6eliA-2hnzA:
36.5		 6eliA-2hnzA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hnz REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H

(Human
immunodeficiency
virus 1) 		PF00075
(RNase_H)
PF00078
(RVT_1)
PF06815
(RVT_connect)
PF06817
(RVT_thumb) 		9 PRO A  95
LEU A 100
VAL A 106
VAL A 179
TYR A 181
PRO A 225
TRP A 229
LEU A 234
TYR A 318
 PC0  A 999 ( 4.9A)
PC0  A 999 ( 3.9A)
PC0  A 999 ( 4.8A)
PC0  A 999 (-4.4A)
PC0  A 999 (-3.9A)
None
PC0  A 999 ( 4.2A)
PC0  A 999 (-4.2A)
PC0  A 999 (-4.3A)
 0.76A 6eliA-2hnzA:
36.5		 6eliA-2hnzA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kkn UNCHARACTERIZED
PROTEIN

(Thermotoga
maritima) 		PF12850
(Metallophos_2) 		5 PRO A 132
LEU A 112
VAL A  58
PHE A   4
LEU A 143
 None
 1.39A 6eliA-2kknA:
undetectable		 6eliA-2kknA:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2l3w PHYCOBILISOME ROD
LINKER POLYPEPTIDE

(Synechococcus
elongatus) 		PF00427
(PBS_linker_poly) 		5 LEU A  85
VAL A  21
TYR A  22
PHE A  54
TYR A 121
 None
 1.49A 6eliA-2l3wA:
undetectable		 6eliA-2l3wA:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lrt UNCHARACTERIZED
PROTEIN

(Bacteroides
vulgatus) 		PF13905
(Thioredoxin_8) 		5 LEU A  76
VAL A 111
TYR A 105
TYR A 109
PHE A 118
 None
 1.06A 6eliA-2lrtA:
undetectable		 6eliA-2lrtA:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lv3 THIOREDOXIN
REDUCTASE 3

(Mus musculus) 		PF00462
(Glutaredoxin) 		5 LEU A 117
VAL A  63
VAL A  97
TYR A  65
LEU A  57
 None
 1.43A 6eliA-2lv3A:
undetectable		 6eliA-2lv3A:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2num UBIQUINOL-CYTOCHROME
C REDUCTASE
IRON-SULFUR SUBUNIT

(Rhodobacter
sphaeroides) 		PF00355
(Rieske) 		5 PRO A 174
LEU A 186
VAL A  54
VAL A  65
PHE A 178
 None
 1.49A 6eliA-2numA:
undetectable		 6eliA-2numA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qvx 4-CHLOROBENZOATE COA
LIGASE

(Alcaligenes sp.
AL3007) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		5 LEU X  30
VAL X 227
VAL X  68
PRO X  24
LEU X  28
 None
 1.29A 6eliA-2qvxX:
undetectable		 6eliA-2qvxX:
9.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vda TRANSLOCASE SUBUNIT
SECA

(Escherichia
coli) 		PF01043
(SecA_PP_bind)
PF07516
(SecA_SW)
PF07517
(SecA_DEAD) 		5 LEU A 387
VAL A 211
VAL A 129
PHE A 401
LEU A 407
 None
 1.39A 6eliA-2vdaA:
2.2		 6eliA-2vdaA:
7.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ve3 PUTATIVE CYTOCHROME
P450 120

(Synechocystis
sp. PCC 6803) 		PF00067
(p450) 		5 LEU A 403
VAL A 154
TYR A 120
PHE A 396
LEU A 399
 None
None
None
HEM  A1444 (-4.7A)
None
 1.49A 6eliA-2ve3A:
undetectable		 6eliA-2ve3A:
11.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x4l FERRIC-SIDEROPHORE
RECEPTOR PROTEIN

(Streptomyces
coelicolor) 		PF01497
(Peripla_BP_2) 		5 PRO A  69
LEU A 190
VAL A  78
VAL A  89
LEU A 186
 None
 1.39A 6eliA-2x4lA:
undetectable		 6eliA-2x4lA:
13.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xa2 TREHALOSE-SYNTHASE
TRET

(Pyrococcus
horikoshii) 		PF00534
(Glycos_transf_1) 		5 PRO A 135
LEU A  95
PRO A 189
TRP A 152
LEU A 158
 None
 1.35A 6eliA-2xa2A:
undetectable		 6eliA-2xa2A:
14.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ybq METHYLTRANSFERASE

(Pseudomonas
aeruginosa) 		PF00590
(TP_methylase) 		5 LEU A  57
VAL A  23
VAL A  47
TRP A  38
LEU A  33
 None
 1.15A 6eliA-2ybqA:
undetectable		 6eliA-2ybqA:
14.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3frn FLAGELLAR PROTEIN
FLGA

(Thermotoga
maritima) 		PF13144
(ChapFlgA) 		5 LEU A  56
VAL A 148
VAL A 139
PRO A 119
TYR A  58
 None
 1.47A 6eliA-3frnA:
undetectable		 6eliA-3frnA:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fut DIMETHYLADENOSINE
TRANSFERASE

(Thermus
thermophilus) 		PF00398
(RrnaAD) 		5 LEU A 130
VAL A 108
TYR A 103
PHE A  51
LEU A 114
 None
 1.27A 6eliA-3futA:
undetectable		 6eliA-3futA:
14.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3icv LIPASE B

(Moesziomyces
antarcticus) 		no annotation 5 LEU A 124
VAL A  71
VAL A 135
PRO A 102
LEU A  54
 None
 1.45A 6eliA-3icvA:
undetectable		 6eliA-3icvA:
12.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iha SALT-TOLERANT
GLUTAMINASE

(Micrococcus
luteus) 		PF04960
(Glutaminase) 		5 PRO A 108
LEU A 174
VAL A 188
TYR A 191
LEU A 170
 None
None
None
GLU  A 500 (-4.1A)
None
 1.22A 6eliA-3ihaA:
undetectable		 6eliA-3ihaA:
9.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l2e GLYCOCYAMINE KINASE
ALPHA CHAIN

(Namalycastis
sp. ST01) 		PF00217
(ATP-gua_Ptrans)
PF02807
(ATP-gua_PtransN) 		5 PRO A 120
LEU A 122
VAL A 248
VAL A 302
TYR A 290
 None
 1.17A 6eliA-3l2eA:
3.4		 6eliA-3l2eA:
13.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l7g XAA-PRO DIPEPTIDASE

(Alteromonas sp.) 		PF00557
(Peptidase_M24) 		5 PRO A  54
LEU A 340
LYS A 160
TYR A 153
TYR A 252
 None
 1.19A 6eliA-3l7gA:
undetectable		 6eliA-3l7gA:
9.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rcn BETA-N-ACETYLHEXOSAM
INIDASE

(Paenarthrobacter
aurescens) 		PF00728
(Glyco_hydro_20)
PF02838
(Glyco_hydro_20b) 		5 LEU A  46
VAL A  85
VAL A  29
TRP A 122
LEU A 106
 None
None
GOL  A 563 ( 4.3A)
None
None
 1.45A 6eliA-3rcnA:
undetectable		 6eliA-3rcnA:
8.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ri6 O-ACETYLHOMOSERINE
SULFHYDRYLASE

(Wolinella
succinogenes) 		PF01053
(Cys_Met_Meta_PP) 		5 LEU A  94
VAL A 252
PRO A 234
TRP A 226
LEU A 232
 None
 1.39A 6eliA-3ri6A:
undetectable		 6eliA-3ri6A:
11.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s9x ASCH DOMAIN

(Vibrio cholerae) 		PF04266
(ASCH) 		5 LEU A  74
TYR A 153
PRO A  84
PHE A   8
LEU A   9
 None
 1.35A 6eliA-3s9xA:
undetectable		 6eliA-3s9xA:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sfz APOPTOTIC PEPTIDASE
ACTIVATING FACTOR 1

(Mus musculus) 		PF00400
(WD40)
PF00931
(NB-ARC)
PF12894
(ANAPC4_WD40) 		5 LEU A 386
TYR A 436
PHE A 425
LEU A 424
TYR A 383
 None
None
ADP  A1250 (-3.4A)
None
None
 1.18A 6eliA-3sfzA:
undetectable		 6eliA-3sfzA:
5.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aej COLLAGEN
ALPHA-1(III) CHAIN

(Homo sapiens) 		PF01410
(COLFI) 		5 PRO A 225
VAL A 239
VAL A  89
TYR A 149
LEU A 171
 None
 1.44A 6eliA-4aejA:
undetectable		 6eliA-4aejA:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b9a PROBABLE EPOXIDE
HYDROLASE

(Pseudomonas
aeruginosa) 		PF00561
(Abhydrolase_1) 		5 PRO A  32
LEU A  33
VAL A 128
PHE A 291
LEU A 292
 GOL  A1313 ( 4.7A)
None
None
None
None
 1.41A 6eliA-4b9aA:
undetectable		 6eliA-4b9aA:
12.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bp8 OLIGOPEPTIDASE B

(Trypanosoma
brucei) 		PF00326
(Peptidase_S9)
PF02897
(Peptidase_S9_N) 		5 PRO A 638
LEU A 640
VAL A 590
VAL A 569
LEU A 663
 None
 1.45A 6eliA-4bp8A:
undetectable		 6eliA-4bp8A:
8.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4by6 GENERAL NEGATIVE
REGULATOR OF
TRANSCRIPTION
SUBUNIT 1

(Saccharomyces
cerevisiae) 		PF04054
(Not1) 		5 VAL A1802
VAL A1798
TYR A1792
PHE A1788
TYR A1839
 None
 1.46A 6eliA-4by6A:
undetectable		 6eliA-4by6A:
8.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c2x GLYCYLPEPTIDE
N-TETRADECANOYLTRANS
FERASE 2

(Homo sapiens) 		PF01233
(NMT)
PF02799
(NMT_C) 		5 LEU A 175
TYR A 180
TYR A 192
PRO A 194
LEU A 172
 None
NHW  A1000 ( 4.6A)
None
None
None
 1.33A 6eliA-4c2xA:
undetectable		 6eliA-4c2xA:
9.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c8d LYSINE-SPECIFIC
DEMETHYLASE 3B

(Homo sapiens) 		PF02373
(JmjC) 		5 LEU A1505
VAL A1420
VAL A1571
PRO A1396
LEU A1509
 None
 1.07A 6eliA-4c8dA:
undetectable		 6eliA-4c8dA:
12.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dcm RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE G

(Escherichia
coli) 		PF05175
(MTS) 		5 LEU A 128
VAL A 158
PRO A 115
LEU A  51
TYR A 103
 None
 1.43A 6eliA-4dcmA:
undetectable		 6eliA-4dcmA:
14.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ewp 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3

(Micrococcus
luteus) 		PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III) 		5 PRO A  24
VAL A 148
VAL A  62
TYR A  22
LEU A 314
 None
 1.49A 6eliA-4ewpA:
undetectable		 6eliA-4ewpA:
10.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fdh CYTOCHROME P450
11B2, MITOCHONDRIAL

(Homo sapiens) 		PF00067
(p450) 		5 PRO A  77
LEU A  93
VAL A 405
PHE A 417
LEU A 416
 None
 1.48A 6eliA-4fdhA:
undetectable		 6eliA-4fdhA:
9.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fqn MALCAVERNIN

(Homo sapiens) 		PF16545
(CCM2_C) 		5 LEU A 338
TYR A 325
PHE A 356
LEU A 353
TYR A 342
 None
 1.41A 6eliA-4fqnA:
undetectable		 6eliA-4fqnA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gdl AUTOPHAGY PROTEIN 5

(Homo sapiens) 		PF04106
(APG5) 		5 LEU B  45
VAL B 102
VAL B  52
TRP B  98
LEU B  77
 None
 1.22A 6eliA-4gdlB:
undetectable		 6eliA-4gdlB:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gxb SORTING NEXIN-17

(Homo sapiens) 		no annotation 5 LEU A 376
VAL A 362
TYR A 352
PHE A 313
LEU A 297
 None
 1.41A 6eliA-4gxbA:
undetectable		 6eliA-4gxbA:
12.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j0k TANNASE

(Lactobacillus
plantarum) 		no annotation 5 PRO A 356
LEU A 360
VAL A  75
PRO A 396
LEU A 209
 None
 1.46A 6eliA-4j0kA:
undetectable		 6eliA-4j0kA:
9.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mfz DBV8 PROTEIN

(Nonomuraea
gerenzanensis) 		no annotation 5 VAL A 147
TYR A 113
TYR A 109
PRO A  51
LEU A  45
 None
 1.33A 6eliA-4mfzA:
undetectable		 6eliA-4mfzA:
12.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pcs ALPHA-L-FUCOSIDASE

(Bacteroides
thetaiotaomicron) 		PF01120
(Alpha_L_fucos) 		5 PRO A 294
LEU A 298
TYR A 397
PRO A 423
PHE A 389
 None
 1.49A 6eliA-4pcsA:
undetectable		 6eliA-4pcsA:
10.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qn9 N-ACYL-PHOSPHATIDYLE
THANOLAMINE-HYDROLYZ
ING PHOSPHOLIPASE D

(Homo sapiens) 		PF12706
(Lactamase_B_2) 		5 LEU A 215
VAL A 181
VAL A 227
PRO A 148
LEU A 191
 None
 1.40A 6eliA-4qn9A:
undetectable		 6eliA-4qn9A:
12.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qpv UNCHARACTERIZED
PROTEIN

(Staphylococcus
aureus) 		PF07901
(DUF1672) 		5 PRO A 241
LEU A 199
VAL A 113
LEU A 160
TYR A 197
 None
 1.32A 6eliA-4qpvA:
3.0		 6eliA-4qpvA:
16.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r12 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Dictyostelium
purpureum) 		PF05450
(Nicastrin) 		5 PRO A 212
LEU A 567
PRO A 321
LEU A 511
TYR A 298
 None
 1.43A 6eliA-4r12A:
undetectable		 6eliA-4r12A:
8.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4raf PROTEIN PHOSPHATASE
1A

(Homo sapiens) 		PF00481
(PP2C)
PF07830
(PP2C_C) 		5 PRO A 343
LEU A 345
VAL A 357
TYR A 311
LEU A 351
 None
 1.44A 6eliA-4rafA:
0.9		 6eliA-4rafA:
12.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rml LATROPHILIN-3

(Mus musculus) 		PF02191
(OLF) 		5 LEU A 444
VAL A 423
VAL A 391
TYR A 389
LEU A 457
 None
 1.20A 6eliA-4rmlA:
undetectable		 6eliA-4rmlA:
11.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tpt LIM DOMAIN KINASE 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 PRO A 616
LYS A 433
VAL A 429
PHE A 576
LEU A 579
 None
 1.41A 6eliA-4tptA:
undetectable		 6eliA-4tptA:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4txk PROTEIN-METHIONINE
SULFOXIDE OXIDASE
MICAL1

(Mus musculus) 		PF00307
(CH)
PF01494
(FAD_binding_3) 		5 LEU A  97
VAL A 173
VAL A  89
TRP A 177
LEU A 165
 None
 1.47A 6eliA-4txkA:
2.3		 6eliA-4txkA:
8.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uwq SULFUR OXIDATION
PROTEIN SOXB

(Thermus
thermophilus) 		PF02872
(5_nucleotid_C) 		5 PRO A 489
LEU A 487
PRO A 557
LEU A 388
TYR A 485
 None
 1.47A 6eliA-4uwqA:
undetectable		 6eliA-4uwqA:
8.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wcj POLYSACCHARIDE
DEACETYLASE

(Ammonifex
degensii) 		PF01522
(Polysacc_deac_1) 		5 LEU A 242
VAL A  89
VAL A  40
TYR A  97
TYR A 219
 None
 1.31A 6eliA-4wcjA:
undetectable		 6eliA-4wcjA:
15.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xgc ORIGIN RECOGNITION
COMPLEX SUBUNIT 5

(Drosophila
melanogaster) 		PF13191
(AAA_16)
PF14630
(ORC5_C) 		5 LEU E 139
VAL E 155
VAL E 125
TYR E  38
LEU E 143
 None
 1.36A 6eliA-4xgcE:
undetectable		 6eliA-4xgcE:
11.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ykc MALCAVERNIN

(Homo sapiens) 		PF16545
(CCM2_C) 		5 LEU A 338
TYR A 325
PHE A 356
LEU A 353
TYR A 342
 None
 1.46A 6eliA-4ykcA:
undetectable		 6eliA-4ykcA:
15.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zr0 CERAMIDE VERY LONG
CHAIN FATTY ACID
HYDROXYLASE SCS7

(Saccharomyces
cerevisiae) 		PF04116
(FA_hydroxylase) 		5 LEU A 243
TYR A 322
TYR A 319
PHE A 288
LEU A 291
 None
 1.32A 6eliA-4zr0A:
undetectable		 6eliA-4zr0A:
9.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zr1 CERAMIDE VERY LONG
CHAIN FATTY ACID
HYDROXYLASE SCS7

(Saccharomyces
cerevisiae) 		PF04116
(FA_hydroxylase) 		5 LEU A 243
TYR A 322
TYR A 319
PHE A 288
LEU A 291
 None
None
None
TRD  A 409 (-4.7A)
TRD  A 409 ( 4.4A)
 1.31A 6eliA-4zr1A:
undetectable		 6eliA-4zr1A:
12.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5c24 HIV-1 REVERSE
TRANSCRIPTASE, P51
SUBUNIT

(Human
immunodeficiency
virus 1) 		PF00078
(RVT_1)
PF06815
(RVT_connect)
PF06817
(RVT_thumb) 		5 LYS B 103
VAL B 106
VAL B 179
TYR B 181
TYR B 188
 None
 0.73A 6eliA-5c24B:
11.9		 6eliA-5c24B:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cmn LATROPHILIN-3

(Homo sapiens) 		PF02191
(OLF) 		5 LEU E 376
VAL E 355
VAL E 323
TYR E 321
LEU E 389
 None
 1.32A 6eliA-5cmnE:
undetectable		 6eliA-5cmnE:
13.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fka STAPHYLOCOCCAL
ENTEROTOXIN E

(Staphylococcus
aureus) 		PF01123
(Stap_Strp_toxin)
PF02876
(Stap_Strp_tox_C) 		5 LEU C 169
LYS C  15
TYR C 231
LEU C 198
TYR C 170
 None
 1.21A 6eliA-5fkaC:
undetectable		 6eliA-5fkaC:
15.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i32 AQUAPORIN TIP2-1

(Arabidopsis
thaliana) 		PF00230
(MIP) 		5 PRO A  84
LEU A 109
VAL A 206
PHE A 211
TRP A 218
 None
 1.35A 6eliA-5i32A:
undetectable		 6eliA-5i32A:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jj4 MALTOSE-BINDING
PERIPLASMIC
PROTEIN,SINGLE-STRAN
DED DNA CYTOSINE
DEAMINASE

(Escherichia
coli;
Homo sapiens) 		no annotation 5 PRO C1086
VAL C1078
VAL C1134
PHE C1061
LEU C1029
 None
 1.44A 6eliA-5jj4C:
undetectable		 6eliA-5jj4C:
8.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k9t PROTEIN TRANSLOCASE
SUBUNIT SECA

(Escherichia
coli) 		PF01043
(SecA_PP_bind)
PF07517
(SecA_DEAD) 		5 LEU A 387
VAL A 211
VAL A 129
PHE A 401
LEU A 407
 None
 1.48A 6eliA-5k9tA:
undetectable		 6eliA-5k9tA:
8.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lxz SECRETED PROTEIN

(Streptomyces
lividans) 		PF07646
(Kelch_2)
PF09118
(DUF1929) 		5 VAL B 280
TYR B 277
PRO B 272
PHE B 270
LEU B 132
 None
 1.42A 6eliA-5lxzB:
undetectable		 6eliA-5lxzB:
9.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m5e CYTOKINE RECEPTOR
COMMON SUBUNIT GAMMA

(Homo sapiens) 		PF00041
(fn3)
PF09240
(IL6Ra-bind) 		5 LEU C 140
VAL C 165
TYR C 197
TYR C 167
PHE C 186
 None
 1.46A 6eliA-5m5eC:
undetectable		 6eliA-5m5eC:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o1m RUBBER OXYGENASE

(Streptomyces
sp. K30) 		PF09995
(DUF2236) 		5 PRO A  90
LEU A  79
VAL A 189
PHE A 100
LEU A  97
 None
 1.47A 6eliA-5o1mA:
undetectable		 6eliA-5o1mA:
12.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ovn POL PROTEIN

(Feline
immunodeficiency
virus) 		no annotation 5 LEU A  99
LYS A 102
VAL A 105
LEU A 233
TYR A 317
 None
 0.80A 6eliA-5ovnA:
25.6		 6eliA-5ovnA:
48.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ovn POL PROTEIN

(Feline
immunodeficiency
virus) 		no annotation 5 PRO A  94
LEU A  99
VAL A 105
LEU A 233
TYR A 317
 None
 1.03A 6eliA-5ovnA:
25.6		 6eliA-5ovnA:
48.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5txe ATXE2

(Asticcacaulis
excentricus) 		PF00326
(Peptidase_S9) 		5 PRO A 371
LEU A 394
VAL A  42
PRO A 423
LEU A 399
 None
 1.11A 6eliA-5txeA:
undetectable		 6eliA-5txeA:
9.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wt7 PERIOSTIN

(Homo sapiens) 		no annotation 5 LEU A   7
VAL A 131
TYR A  73
PHE A  17
LEU A  11
 None
 1.42A 6eliA-5wt7A:
undetectable		 6eliA-5wt7A:
26.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wve APOPTOTIC
PROTEASE-ACTIVATING
FACTOR 1

(Homo sapiens) 		PF00400
(WD40)
PF00931
(NB-ARC) 		5 LEU A 386
TYR A 436
PHE A 425
LEU A 424
TYR A 383
 None
 1.25A 6eliA-5wveA:
undetectable		 6eliA-5wveA:
5.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xfm ALPHA-GLUCOSIDASE

(Bacteroides
thetaiotaomicron) 		no annotation 5 VAL A 214
VAL A 239
TYR A 237
PHE A 153
TYR A  45
 None
 1.27A 6eliA-5xfmA:
undetectable		 6eliA-5xfmA:
28.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fzw COLLAGEN
ALPHA-1(III) CHAIN

(Homo sapiens) 		no annotation 5 PRO A 225
VAL A 239
VAL A  89
TYR A 149
LEU A 171
 None
 1.38A 6eliA-6fzwA:
undetectable		 6eliA-6fzwA:
22.78