SIMILAR PATTERNS OF AMINO ACIDS FOR 6EKZ_A_SNPA416_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2yp1 AROMATIC
PEROXYGENASE

(Agrocybe
aegerita) 		PF01328
(Peroxidase_2) 		4 LYS A 290
VAL A 298
ARG A 301
TYR A 325
 NAG  A 391 (-3.0A)
None
None
None
 0.50A 6ekzA-2yp1A:
56.6		 6ekzA-2yp1A:
96.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kju SHIKIMATE
O-HYDROXYCINNAMOYLTR
ANSFERASE

(Arabidopsis
thaliana) 		PF02458
(Transferase) 		4 LYS A 278
VAL A 355
ARG A 356
TYR A 280
 None
None
6TO  A 800 (-3.9A)
None
 1.47A 6ekzA-5kjuA:
0.0		 6ekzA-5kjuA:
9.93