SIMILAR PATTERNS OF AMINO ACIDS FOR 6EKZ_A_SNPA414

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c9w CHO REDUCTASE

(Cricetulus
griseus) 		PF00248
(Aldo_ket_red) 		4 PHE A 276
VAL A  33
PRO A 261
VAL A 275
 None
None
NAP  A 350 (-4.9A)
None
 1.36A 6ekzA-1c9wA:
0.0		 6ekzA-1c9wA:
14.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cvr GINGIPAIN R

(Porphyromonas
gingivalis) 		PF01364
(Peptidase_C25)
PF03785
(Peptidase_C25_C) 		4 PHE A  27
VAL A 418
MET A  12
VAL A  28
 None
 0.93A 6ekzA-1cvrA:
0.0		 6ekzA-1cvrA:
10.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d1t ALCOHOL
DEHYDROGENASE CLASS
IV SIGMA CHAIN

(Homo sapiens) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 PHE A 140
VAL A 203
MET A  57
VAL A  65
 None
NAD  A1377 (-3.7A)
None
None
 1.27A 6ekzA-1d1tA:
undetectable		 6ekzA-1d1tA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fs0 ATP SYNTHASE GAMMA
SUBUNIT

(Escherichia
coli) 		PF00231
(ATP-synt) 		4 VAL G 123
PRO G 152
MET G 156
VAL G 228
 None
 1.37A 6ekzA-1fs0G:
0.0		 6ekzA-1fs0G:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gq2 MALIC ENZYME

(Columba livia) 		PF00390
(malic)
PF03949
(Malic_M) 		4 PHE A 254
VAL A 478
MET A 239
VAL A 160
 None
 0.85A 6ekzA-1gq2A:
0.0		 6ekzA-1gq2A:
9.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gyn FRUCTOSE-BISPHOSPHAT
E ALDOLASE II

(Escherichia
coli) 		PF01116
(F_bP_aldolase) 		4 PHE A  21
VAL A 102
PRO A  32
VAL A 283
 None
 1.43A 6ekzA-1gynA:
0.0		 6ekzA-1gynA:
13.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gz4 NAD-DEPENDENT MALIC
ENZYME

(Homo sapiens) 		PF00390
(malic)
PF03949
(Malic_M) 		4 PHE A 254
VAL A 478
MET A 239
VAL A 160
 None
 0.92A 6ekzA-1gz4A:
0.0		 6ekzA-1gz4A:
10.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iap GUANINE NUCLEOTIDE
EXCHANGE FACTOR
P115RHOGEF

(Homo sapiens) 		PF09128
(RGS-like) 		4 PHE A  46
VAL A 179
PRO A  56
VAL A  52
 None
 1.25A 6ekzA-1iapA:
0.0		 6ekzA-1iapA:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jmz AMINE DEHYDROGENASE

(Pseudomonas
putida) 		PF09098
(Dehyd-heme_bind)
PF09099
(Qn_am_d_aIII)
PF09100
(Qn_am_d_aIV)
PF14930
(Qn_am_d_aII) 		4 PHE A 224
VAL A 202
MET A 264
VAL A 196
 None
 1.28A 6ekzA-1jmzA:
0.0		 6ekzA-1jmzA:
10.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1keh PRECURSOR OF
CEPHALOSPORIN
ACYLASE

(Brevundimonas
diminuta) 		PF01804
(Penicil_amidase) 		4 VAL A 310
PRO A 316
MET A 318
VAL A 138
 None
 1.34A 6ekzA-1kehA:
undetectable		 6ekzA-1kehA:
10.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mdf 2,3-DIHYDROXYBENZOAT
E-AMP LIGASE

(Bacillus
subtilis) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		4 PHE A  67
VAL A 179
PRO A 102
VAL A  91
 None
 1.15A 6ekzA-1mdfA:
undetectable		 6ekzA-1mdfA:
14.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q5d P450 EPOXIDASE

(Sorangium
cellulosum) 		PF00067
(p450) 		4 PHE A  96
VAL A 110
PRO A 362
VAL A  69
 EPB  A 450 ( 3.6A)
None
None
None
 1.39A 6ekzA-1q5dA:
undetectable		 6ekzA-1q5dA:
13.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qnr ENDO-1,4-B-D-MANNANA
SE

(Trichoderma
reesei) 		PF00150
(Cellulase) 		4 PHE A 240
VAL A  52
PRO A 271
MET A 300
 None
 1.22A 6ekzA-1qnrA:
undetectable		 6ekzA-1qnrA:
13.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qvz YDR533C PROTEIN

(Saccharomyces
cerevisiae) 		PF01965
(DJ-1_PfpI) 		4 PHE A 102
PRO A 141
MET A 143
VAL A 134
 None
CSO  A 138 ( 4.3A)
None
None
 0.83A 6ekzA-1qvzA:
undetectable		 6ekzA-1qvzA:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sy7 CATALASE 1

(Neurospora
crassa) 		PF00199
(Catalase)
PF01965
(DJ-1_PfpI)
PF06628
(Catalase-rel) 		4 PHE A 696
VAL A 558
PRO A 623
VAL A 569
 None
 1.22A 6ekzA-1sy7A:
undetectable		 6ekzA-1sy7A:
8.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tp7 GENOME POLYPROTEIN

(Rhinovirus A) 		PF00680
(RdRP_1) 		4 PHE A  30
PRO A 406
MET A 409
VAL A  29
 None
 1.12A 6ekzA-1tp7A:
undetectable		 6ekzA-1tp7A:
12.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u2v ARP2/3 COMPLEX 34KDA
SUBUNIT

(Bos taurus) 		PF04045
(P34-Arc) 		4 PHE D 125
VAL D  41
MET D 152
VAL D 124
 None
 1.16A 6ekzA-1u2vD:
undetectable		 6ekzA-1u2vD:
14.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uyp BETA-FRUCTOSIDASE

(Thermotoga
maritima) 		PF00251
(Glyco_hydro_32N)
PF08244
(Glyco_hydro_32C) 		4 PHE A 392
VAL A 420
MET A 338
VAL A 356
 None
 1.24A 6ekzA-1uypA:
undetectable		 6ekzA-1uypA:
10.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xr6 GENOME POLYPROTEIN

(Rhinovirus A) 		PF00680
(RdRP_1) 		4 PHE A  30
PRO A 406
MET A 409
VAL A  29
 None
 1.10A 6ekzA-1xr6A:
undetectable		 6ekzA-1xr6A:
13.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aw5 NADP-DEPENDENT MALIC
ENZYME

(Homo sapiens) 		PF00390
(malic)
PF03949
(Malic_M) 		4 PHE A 244
VAL A 465
MET A 229
VAL A 150
 None
 0.86A 6ekzA-2aw5A:
undetectable		 6ekzA-2aw5A:
10.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cr4 SH3 DOMAIN-BINDING
PROTEIN 2

(Homo sapiens) 		PF00017
(SH2) 		4 PHE A  90
VAL A  59
PRO A 106
VAL A  88
 None
 1.24A 6ekzA-2cr4A:
undetectable		 6ekzA-2cr4A:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qfz TBC1 DOMAIN FAMILY
MEMBER 22A

(Homo sapiens) 		PF00566
(RabGAP-TBC) 		4 PHE A 302
PRO A 285
MET A 287
VAL A 298
 None
 1.19A 6ekzA-2qfzA:
undetectable		 6ekzA-2qfzA:
14.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r1v DJ-1

(Homo sapiens) 		PF01965
(DJ-1_PfpI) 		4 VAL A 146
PRO A  22
MET A  26
VAL A   8
 None
 1.29A 6ekzA-2r1vA:
undetectable		 6ekzA-2r1vA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v6o THIOREDOXIN
GLUTATHIONE
REDUCTASE

(Schistosoma
mansoni) 		PF00462
(Glutaredoxin)
PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		4 PHE A 343
VAL A 519
PRO A 476
VAL A 341
 PG4  A1597 (-3.7A)
None
None
None
 1.28A 6ekzA-2v6oA:
undetectable		 6ekzA-2v6oA:
9.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vf1 CAPSID PROTEIN

(Rabbit
picobirnavirus) 		no annotation 4 PHE A 272
VAL A 298
PRO A 130
VAL A 254
 None
 0.96A 6ekzA-2vf1A:
undetectable		 6ekzA-2vf1A:
10.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vpn PERIPLASMIC
SUBSTRATE BINDING
PROTEIN

(Halomonas
elongata) 		PF03480
(DctP) 		4 PHE A  77
VAL A 310
PRO A 120
MET A 118
 None
 1.30A 6ekzA-2vpnA:
undetectable		 6ekzA-2vpnA:
13.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wj3 1-H-3-HYDROXY-4-OXOQ
UINALDINE
2,4-DIOXYGENASE

(Paenarthrobacter
nitroguajacolicus) 		PF00561
(Abhydrolase_1) 		4 PHE A 252
VAL A  58
MET A 177
VAL A 169
 None
 1.41A 6ekzA-2wj3A:
undetectable		 6ekzA-2wj3A:
12.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ww9 SEC SIXTY-ONE
PROTEIN HOMOLOG

(Saccharomyces
cerevisiae) 		PF00344
(SecY)
PF10559
(Plug_translocon) 		4 PHE A 141
VAL A 312
PRO A  76
VAL A  61
 None
 1.40A 6ekzA-2ww9A:
undetectable		 6ekzA-2ww9A:
12.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wya HYDROXYMETHYLGLUTARY
L-COA SYNTHASE,
MITOCHONDRIAL

(Homo sapiens) 		PF01154
(HMG_CoA_synt_N)
PF08540
(HMG_CoA_synt_C) 		4 PHE A 149
PRO A 120
MET A 114
VAL A 124
 None
 1.23A 6ekzA-2wyaA:
undetectable		 6ekzA-2wyaA:
12.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y3a PHOSPHATIDYLINOSITOL
-4,5-BISPHOSPHATE
3-KINASE CATALYTIC
SUBUNIT BETA ISOFORM

(Mus musculus) 		PF00454
(PI3_PI4_kinase)
PF00613
(PI3Ka)
PF00792
(PI3K_C2)
PF00794
(PI3K_rbd)
PF02192
(PI3K_p85B) 		4 PHE A 645
VAL A 618
PRO A 609
MET A 391
 None
 1.30A 6ekzA-2y3aA:
undetectable		 6ekzA-2y3aA:
6.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2yp1 AROMATIC
PEROXYGENASE

(Agrocybe
aegerita) 		PF01328
(Peroxidase_2) 		4 PHE A  76
PRO A 277
MET A 280
VAL A 315
 None
SO4  A1331 (-3.4A)
None
None
 0.65A 6ekzA-2yp1A:
56.6		 6ekzA-2yp1A:
96.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2yp1 AROMATIC
PEROXYGENASE

(Agrocybe
aegerita) 		PF01328
(Peroxidase_2) 		4 VAL A 244
PRO A 277
MET A 280
VAL A 315
 None
SO4  A1331 (-3.4A)
None
None
 0.61A 6ekzA-2yp1A:
56.6		 6ekzA-2yp1A:
96.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z8h TRANSCRIPTION
REGULATOR PROTEIN
BACH1

(Mus musculus) 		PF00651
(BTB) 		4 PHE A  45
VAL A 115
PRO A  86
VAL A  81
 None
 1.36A 6ekzA-2z8hA:
undetectable		 6ekzA-2z8hA:
15.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zf8 COMPONENT OF
SODIUM-DRIVEN POLAR
FLAGELLAR MOTOR

(Vibrio
alginolyticus) 		PF00691
(OmpA) 		4 VAL A  65
PRO A 114
MET A  70
VAL A   7
 None
 1.38A 6ekzA-2zf8A:
undetectable		 6ekzA-2zf8A:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zj9 AMPC

(Escherichia
coli) 		PF00144
(Beta-lactamase) 		4 PHE A  69
VAL A 191
MET A 230
VAL A  65
 None
 1.37A 6ekzA-2zj9A:
undetectable		 6ekzA-2zj9A:
11.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3abz BETA-GLUCOSIDASE I

(Kluyveromyces
marxianus) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF07691
(PA14)
PF14310
(Fn3-like) 		4 PHE A 148
VAL A 133
PRO A 176
VAL A 149
 None
 0.79A 6ekzA-3abzA:
undetectable		 6ekzA-3abzA:
9.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3clq UNCHARACTERIZED
PROTEIN

(Enterococcus
faecalis) 		PF06545
(DUF1116) 		4 PHE A 462
VAL A 340
MET A 313
VAL A 461
 None
 1.32A 6ekzA-3clqA:
undetectable		 6ekzA-3clqA:
12.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e53 FATTY-ACID-COA
LIGASE FADD28

(Mycobacterium
tuberculosis) 		PF00501
(AMP-binding) 		4 PHE A 219
VAL A 336
PRO A 232
VAL A  76
 None
 1.17A 6ekzA-3e53A:
undetectable		 6ekzA-3e53A:
9.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ek1 ALDEHYDE
DEHYDROGENASE

(Brucella
abortus) 		PF00171
(Aldedh) 		4 PHE A 396
VAL A 381
PRO A 262
VAL A 402
 None
 1.37A 6ekzA-3ek1A:
undetectable		 6ekzA-3ek1A:
12.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hpf MUCONATE
CYCLOISOMERASE

(Oceanobacillus
iheyensis) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 PHE A 271
VAL A 292
PRO A 323
VAL A 270
 GAE  A 411 (-4.8A)
None
None
None
 1.38A 6ekzA-3hpfA:
undetectable		 6ekzA-3hpfA:
10.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ipl 2-SUCCINYLBENZOATE--
COA LIGASE

(Staphylococcus
aureus) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		4 PHE A 375
VAL A 389
MET A 305
VAL A 356
 None
 1.41A 6ekzA-3iplA:
undetectable		 6ekzA-3iplA:
10.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3knu TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE

(Anaplasma
phagocytophilum) 		PF01746
(tRNA_m1G_MT) 		4 VAL A  49
PRO A  10
MET A  12
VAL A   5
 None
 1.35A 6ekzA-3knuA:
undetectable		 6ekzA-3knuA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lkb PROBABLE
BRANCHED-CHAIN AMINO
ACID ABC
TRANSPORTER, AMINO
ACID BINDING PROTEIN

(Thermus
thermophilus) 		PF13458
(Peripla_BP_6) 		4 PHE A  67
VAL A  31
PRO A  77
VAL A  71
 None
 1.04A 6ekzA-3lkbA:
undetectable		 6ekzA-3lkbA:
13.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lxx GTPASE IMAP FAMILY
MEMBER 4

(Homo sapiens) 		PF04548
(AIG1) 		4 PHE A 153
VAL A 212
MET A 179
VAL A 121
 None
 0.99A 6ekzA-3lxxA:
undetectable		 6ekzA-3lxxA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3max HISTONE DEACETYLASE
2

(Homo sapiens) 		PF00850
(Hist_deacetyl) 		4 PHE A 296
VAL A 229
PRO A 248
VAL A 292
 None
 1.33A 6ekzA-3maxA:
undetectable		 6ekzA-3maxA:
10.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n2o BIOSYNTHETIC
ARGININE
DECARBOXYLASE

(Vibrio
vulnificus) 		PF02784
(Orn_Arg_deC_N) 		4 PHE A 546
VAL A 359
MET A  36
VAL A 354
 None
 1.37A 6ekzA-3n2oA:
undetectable		 6ekzA-3n2oA:
7.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oaa ATP SYNTHASE GAMMA
CHAIN

(Escherichia
coli) 		PF00231
(ATP-synt) 		4 VAL G 122
PRO G 151
MET G 155
VAL G 227
 None
 1.33A 6ekzA-3oaaG:
undetectable		 6ekzA-3oaaG:
14.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p2m POSSIBLE HYDROLASE

(Mycobacterium
tuberculosis) 		PF12697
(Abhydrolase_6) 		4 PHE A  86
VAL A  67
PRO A 107
VAL A  84
 None
 1.35A 6ekzA-3p2mA:
undetectable		 6ekzA-3p2mA:
13.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p3l CYTOCHROME P450

(Streptomyces
thioluteus) 		PF00067
(p450) 		4 VAL A 393
PRO A 148
MET A 152
VAL A 166
 None
None
HEM  A 501 ( 3.9A)
None
 1.25A 6ekzA-3p3lA:
undetectable		 6ekzA-3p3lA:
12.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qc2 GLYCOSYL HYDROLASE

(Bacteroides
ovatus) 		PF04041
(Glyco_hydro_130) 		4 PHE A 119
VAL A 126
PRO A  78
VAL A  50
 None
 1.30A 6ekzA-3qc2A:
undetectable		 6ekzA-3qc2A:
12.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r4q LACTOYLGLUTATHIONE
LYASE

(Agrobacterium
fabrum) 		PF00903
(Glyoxalase) 		4 PHE A  30
VAL A  43
PRO A 122
VAL A  29
 None
 1.11A 6ekzA-3r4qA:
undetectable		 6ekzA-3r4qA:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cmw DITERPENE SYNTHASE

(Mycobacterium
tuberculosis) 		no annotation 4 PHE A 120
VAL A 198
PRO A  77
VAL A 160
 None
 1.32A 6ekzA-4cmwA:
undetectable		 6ekzA-4cmwA:
13.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dmg PUTATIVE
UNCHARACTERIZED
PROTEIN TTHA1493

(Thermus
thermophilus) 		PF02475
(Met_10) 		4 PHE A  78
VAL A 147
MET A 127
VAL A 133
 None
 0.96A 6ekzA-4dmgA:
undetectable		 6ekzA-4dmgA:
12.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dqn PUTATIVE
BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE
ILVE

(Streptococcus
mutans) 		PF01063
(Aminotran_4) 		4 PHE A 301
VAL A 221
PRO A 163
VAL A 303
 None
 1.34A 6ekzA-4dqnA:
undetectable		 6ekzA-4dqnA:
13.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e1o HISTIDINE
DECARBOXYLASE

(Homo sapiens) 		PF00282
(Pyridoxal_deC) 		4 PHE A 448
VAL A  70
PRO A  75
VAL A 450
 None
 1.35A 6ekzA-4e1oA:
undetectable		 6ekzA-4e1oA:
11.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fmf POLIOVIRUS
RECEPTOR-RELATED
PROTEIN 1

(Homo sapiens) 		PF07686
(V-set)
PF08205
(C2-set_2)
PF13927
(Ig_3) 		4 PHE A 126
VAL A  48
PRO A 102
VAL A  65
 None
 1.35A 6ekzA-4fmfA:
undetectable		 6ekzA-4fmfA:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4grv NEUROTENSIN RECEPTOR
TYPE 1, LYSOZYME
CHIMERA

(Rattus
norvegicus;
Escherichia
virus T4) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		4 PHE A 376
VAL A 259
PRO A 174
VAL A 379
 None
 1.33A 6ekzA-4grvA:
undetectable		 6ekzA-4grvA:
10.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hc5 GLYOXALASE/BLEOMYCIN
RESISTANCE
PROTEIN/DIOXYGENASE

(Sphaerobacter
thermophilus) 		PF00903
(Glyoxalase) 		4 PHE A 126
VAL A  99
PRO A 105
VAL A 128
 None
GOL  A 302 (-3.6A)
None
None
 1.19A 6ekzA-4hc5A:
undetectable		 6ekzA-4hc5A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i1p MUCOSA-ASSOCIATED
LYMPHOID TISSUE
LYMPHOMA
TRANSLOCATION
PROTEIN 1

(Homo sapiens) 		PF00656
(Peptidase_C14) 		4 PHE A 459
VAL A 381
MET A 449
VAL A 442
 None
 1.43A 6ekzA-4i1pA:
undetectable		 6ekzA-4i1pA:
11.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ifq NUCLEOPORIN NUP192

(Saccharomyces
cerevisiae) 		PF11894
(Nup192) 		4 PHE A 887
VAL A 875
PRO A 826
VAL A 890
 None
 1.30A 6ekzA-4ifqA:
undetectable		 6ekzA-4ifqA:
6.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mni TRAP DICARBOXYLATE
TRANSPORTER-DCTP
SUBUNIT

(Polaromonas sp.
JS666) 		PF03480
(DctP) 		4 PHE A 319
VAL A 172
PRO A 103
VAL A 315
 None
173  A 401 (-4.6A)
None
None
 1.31A 6ekzA-4mniA:
undetectable		 6ekzA-4mniA:
13.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4my5 PUTATIVE AMINO ACID
AMINOTRANSFERASE

(Streptococcus
mutans) 		PF00155
(Aminotran_1_2) 		4 PHE A 350
VAL A 329
MET A 379
VAL A 348
 None
 1.11A 6ekzA-4my5A:
undetectable		 6ekzA-4my5A:
12.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nle ADENYLOSUCCINATE
LYASE

(Mycolicibacterium
smegmatis) 		PF00206
(Lyase_1)
PF10397
(ADSL_C) 		4 VAL A 455
PRO A 252
MET A 255
VAL A 348
 None
 0.76A 6ekzA-4nleA:
undetectable		 6ekzA-4nleA:
10.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pf1 PEPTIDASE
S15/COCE/NOND

(Thaumarchaeota
archaeon SCGC
AB-539-E09) 		PF02129
(Peptidase_S15)
PF08530
(PepX_C) 		4 PHE A 181
VAL A 282
MET A 353
VAL A 287
 None
 1.22A 6ekzA-4pf1A:
undetectable		 6ekzA-4pf1A:
9.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q9n ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[NADH]

(Chlamydia
trachomatis) 		PF13561
(adh_short_C2) 		4 PHE A  12
PRO A  77
MET A  78
VAL A  39
 None
 1.23A 6ekzA-4q9nA:
undetectable		 6ekzA-4q9nA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qqv INTERLEUKIN-3
RECEPTOR CLASS 2
SUBUNIT BETA

(Mus musculus) 		PF09240
(IL6Ra-bind)
PF09294
(Interfer-bind) 		4 PHE A 153
VAL A 113
PRO A 117
VAL A 194
 None
 1.37A 6ekzA-4qqvA:
undetectable		 6ekzA-4qqvA:
11.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tv6 2-DEHYDRO-3-DEOXYGLU
CARATE ALDOLASE

(Staphylococcus
aureus) 		PF03328
(HpcH_HpaI) 		4 PHE A 211
VAL A  42
PRO A 215
VAL A 229
 None
 1.10A 6ekzA-4tv6A:
undetectable		 6ekzA-4tv6A:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u0t ADC-7 BETA-LACTAMASE

(Acinetobacter
baumannii) 		PF00144
(Beta-lactamase) 		4 PHE A  69
VAL A 191
MET A 231
VAL A  65
 None
 1.34A 6ekzA-4u0tA:
undetectable		 6ekzA-4u0tA:
13.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u4p STRUCTURAL
MAINTENANCE OF
CHROMOSOMES PROTEIN
4

(Homo sapiens) 		PF06470
(SMC_hinge) 		4 PHE B 708
VAL B 717
MET B 763
VAL B 699
 None
 1.32A 6ekzA-4u4pB:
undetectable		 6ekzA-4u4pB:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u90 GEPHYRIN

(Rattus
norvegicus) 		PF00994
(MoCF_biosynth)
PF03453
(MoeA_N)
PF03454
(MoeA_C) 		4 PHE A 638
VAL A 574
PRO A 603
MET A 601
 None
 1.25A 6ekzA-4u90A:
undetectable		 6ekzA-4u90A:
12.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uul L-LACTATE
DEHYDROGENASE

(Trichomonas
vaginalis) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		4 PHE A 285
VAL A 264
PRO A 276
VAL A 271
 None
 1.20A 6ekzA-4uulA:
undetectable		 6ekzA-4uulA:
12.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wx6 PROTEASE

(Human
mastadenovirus
D) 		PF00770
(Peptidase_C5) 		4 PHE A  58
PRO A  30
MET A  91
VAL A  43
 None
 0.91A 6ekzA-4wx6A:
undetectable		 6ekzA-4wx6A:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y0i 4-AMINOBUTYRATE
AMINOTRANSFERASE,
MITOCHONDRIAL

(Sus scrofa) 		PF00202
(Aminotran_3) 		4 PHE A 310
VAL A 297
MET A 331
VAL A 122
 None
 1.27A 6ekzA-4y0iA:
undetectable		 6ekzA-4y0iA:
12.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y0m OXYR

(Pseudomonas
aeruginosa) 		PF03466
(LysR_substrate) 		4 PHE A 161
VAL A 267
PRO A 244
VAL A 272
 None
 1.36A 6ekzA-4y0mA:
undetectable		 6ekzA-4y0mA:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yji ARYL ACYLAMIDASE

(bacterium
CSBL00001) 		PF01425
(Amidase) 		4 PHE A 297
VAL A 307
MET A 458
VAL A 296
 None
 1.41A 6ekzA-4yjiA:
undetectable		 6ekzA-4yjiA:
10.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zxc HYDROQUINONE
DIOXYGENASE LARGE
SUBUNIT

(Pseudomonas sp.
WBC-3) 		no annotation 4 PHE W 144
VAL W  83
PRO W 232
VAL W 228
 None
 1.36A 6ekzA-4zxcW:
undetectable		 6ekzA-4zxcW:
13.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a7v PUTATIVE GLYCOSIDASE
PH117-RELATED

(Bacteroides
thetaiotaomicron) 		PF04041
(Glyco_hydro_130) 		4 PHE B 116
VAL B 123
PRO B  75
VAL B  47
 None
 1.29A 6ekzA-5a7vB:
undetectable		 6ekzA-5a7vB:
10.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b1u METALLO-BETA-LACTAMA
SE

(Serratia
marcescens) 		PF00753
(Lactamase_B) 		4 PHE A  12
VAL A  40
PRO A 216
MET A 221
 None
 1.16A 6ekzA-5b1uA:
undetectable		 6ekzA-5b1uA:
16.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5czl GLUCANASE

(Raoultella
ornithinolytica) 		PF01270
(Glyco_hydro_8) 		4 PHE A 250
VAL A 264
PRO A 259
MET A 274
 None
 1.32A 6ekzA-5czlA:
undetectable		 6ekzA-5czlA:
13.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dkx ALPHA
GLUCOSIDASE-LIKE
PROTEIN

(Chaetomium
thermophilum) 		PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2)
PF17137
(DUF5110) 		4 PHE A 563
PRO A 560
MET A 557
VAL A 568
 None
None
TRS  A1001 (-3.5A)
None
 1.34A 6ekzA-5dkxA:
undetectable		 6ekzA-5dkxA:
6.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e2h BETA-LACTAMASE

(Mycolicibacterium
smegmatis) 		PF00144
(Beta-lactamase) 		4 PHE A  63
VAL A 185
MET A 225
VAL A  59
 None
CL  A 401 (-4.1A)
None
None
 1.40A 6ekzA-5e2hA:
undetectable		 6ekzA-5e2hA:
13.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ggg PROTEIN
O-LINKED-MANNOSE
BETA-1,2-N-ACETYLGLU
COSAMINYLTRANSFERASE
1

(Homo sapiens) 		PF03071
(GNT-I)
PF15711
(ILEI) 		4 PHE A 268
VAL A 335
PRO A 312
VAL A 272
 None
 1.35A 6ekzA-5gggA:
undetectable		 6ekzA-5gggA:
8.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hjr NEUTRAL
ALPHA-GLUCOSIDASE AB

(Mus musculus) 		PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2) 		4 PHE A 571
PRO A 568
MET A 565
VAL A 576
 None
None
5GF  A1021 (-2.6A)
None
 1.33A 6ekzA-5hjrA:
undetectable		 6ekzA-5hjrA:
8.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i61 POTENTIAL
RNA-DEPENDENT RNA
POLYMERASE

(Human
picobirnavirus) 		no annotation 4 PHE B 208
VAL B 297
MET B 136
VAL B 154
 None
 1.40A 6ekzA-5i61B:
undetectable		 6ekzA-5i61B:
10.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i92 GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE

(Pseudomonas
aeruginosa) 		PF00202
(Aminotran_3) 		4 PHE A 138
VAL A 371
PRO A 215
VAL A 203
 None
 1.24A 6ekzA-5i92A:
undetectable		 6ekzA-5i92A:
11.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iig VACUOLAR TRANSPORTER
CHAPERONE 4

(Saccharomyces
cerevisiae) 		PF03105
(SPX)
PF09359
(VTC) 		4 PHE A 459
VAL A 278
PRO A 353
VAL A 355
 None
 1.42A 6ekzA-5iigA:
undetectable		 6ekzA-5iigA:
8.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5irc RHO
GTPASE-ACTIVATING
PROTEIN 35

(Rattus
norvegicus) 		PF00620
(RhoGAP) 		4 PHE A1372
VAL A1255
PRO A1365
VAL A1333
 None
 1.25A 6ekzA-5ircA:
undetectable		 6ekzA-5ircA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iw4 NADH PYROPHOSPHATASE

(Escherichia
coli) 		PF00293
(NUDIX)
PF09297
(zf-NADH-PPase) 		4 VAL A  68
PRO A 193
MET A 201
VAL A 240
 None
None
NAD  A 501 (-3.5A)
NAD  A 501 (-4.5A)
 1.16A 6ekzA-5iw4A:
undetectable		 6ekzA-5iw4A:
14.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5koi ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[NADH]

(Brucella
abortus) 		PF13561
(adh_short_C2) 		4 PHE A  76
VAL A 119
MET A  13
VAL A  75
 None
 1.42A 6ekzA-5koiA:
undetectable		 6ekzA-5koiA:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5np4 TRANSCOBALAMIN-2

(Homo sapiens) 		PF14478
(DUF4430) 		4 PHE A 376
VAL A 337
PRO A 386
VAL A 407
 CNC  A 502 ( 4.2A)
None
None
None
 1.42A 6ekzA-5np4A:
undetectable		 6ekzA-5np4A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nr1 FTSZ-BINDING PROTEIN
FZLA

(Caulobacter
vibrioides) 		PF00043
(GST_C)
PF13417
(GST_N_3) 		4 VAL A 178
PRO A  54
MET A  52
VAL A  35
 None
 1.19A 6ekzA-5nr1A:
undetectable		 6ekzA-5nr1A:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oon UNDECAPRENYL-DIPHOSP
HATASE

(Escherichia
coli) 		no annotation 4 PHE A  22
PRO A 202
MET A 204
VAL A  60
 None
 1.25A 6ekzA-5oonA:
undetectable		 6ekzA-5oonA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5osb PROTON-GATED ION
CHANNEL,GAMMA-AMINOB
UTYRIC ACID RECEPTOR
SUBUNIT
ALPHA-1,GAMMA-AMINOB
UTYRIC ACID RECEPTOR
SUBUNIT ALPHA-1

(Mus musculus;
Gloeobacter
violaceus) 		no annotation 4 PHE A 257
VAL A 306
PRO A 252
VAL A 256
 None
 1.42A 6ekzA-5osbA:
undetectable		 6ekzA-5osbA:
13.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wc8 SIAD

(Mannheimia
haemolytica) 		no annotation 4 PHE M 361
VAL M 301
PRO M 263
VAL M 365
 None
 1.18A 6ekzA-5wc8M:
undetectable		 6ekzA-5wc8M:
10.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xhb NISIN IMMUNITY
PROTEIN

(Lactococcus
lactis) 		no annotation 4 PHE A  38
VAL A  70
MET A 103
VAL A  28
 None
 1.21A 6ekzA-5xhbA:
undetectable		 6ekzA-5xhbA:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6czx PHOSPHOSERINE
AMINOTRANSFERASE 1,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		no annotation 4 PHE A 320
VAL A 105
PRO A 269
VAL A 319
 None
 1.33A 6ekzA-6czxA:
undetectable		 6ekzA-6czxA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6evj RNA-DIRECTED RNA
POLYMERASE CATALYTIC
SUBUNIT

(Influenza A
virus) 		no annotation 4 PHE B 166
VAL B 181
MET B 246
VAL B 170
 None
 1.41A 6ekzA-6evjB:
undetectable		 6ekzA-6evjB:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fth EXTRACELLULAR
SOLUTE-BINDING
PROTEIN, FAMILY 1

(Bifidobacterium
longum) 		no annotation 4 VAL A 312
PRO A 305
MET A 145
VAL A 159
 None
 1.30A 6ekzA-6fthA:
undetectable		 6ekzA-6fthA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6g43 PUTATIVE MAJOR
CAPSID PROTEIN

(Cafeteriavirus-dependent
mavirus) 		no annotation 4 PHE A 260
VAL A 255
PRO A  98
VAL A  73
 None
 1.35A 6ekzA-6g43A:
undetectable		 6ekzA-6g43A:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gbc MOLYBDOPTERIN
BIOSYNTHESIS PROTEIN
CNX1

(Arabidopsis
thaliana) 		no annotation 4 PHE A 336
VAL A 268
PRO A 295
MET A 293
 None
 1.36A 6ekzA-6gbcA:
undetectable		 6ekzA-6gbcA:
undetectable