SIMILAR PATTERNS OF AMINO ACIDS FOR 6EKZ_A_SNPA413_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dqw OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE

(Saccharomyces
cerevisiae) 		PF00215
(OMPdecase) 		4 GLY A  98
SER A 131
GLY A 132
VAL A 101
 None
 0.97A 6ekzA-1dqwA:
0.0		 6ekzA-1dqwA:
14.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ffv CUTL, MOLYBDOPROTEIN
OF CARBON MONOXIDE
DEHYDROGENASE

(Hydrogenophaga
pseudoflava) 		PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2) 		4 GLN B 522
GLY B 754
SER B 566
VAL B 484
 PCD  B1920 (-4.2A)
PCD  B1920 (-3.6A)
PCD  B1920 (-2.7A)
None
 0.71A 6ekzA-1ffvB:
0.0		 6ekzA-1ffvB:
7.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ffv CUTL, MOLYBDOPROTEIN
OF CARBON MONOXIDE
DEHYDROGENASE

(Hydrogenophaga
pseudoflava) 		PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2) 		4 GLY B 487
PHE B 649
GLY B 485
VAL B 569
 None
 0.82A 6ekzA-1ffvB:
0.0		 6ekzA-1ffvB:
7.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gfn MATRIX PORIN OUTER
MEMBRANE PROTEIN F

(Escherichia
coli) 		PF00267
(Porin_1) 		4 GLN A  60
GLY A 134
GLY A  99
VAL A 136
 None
 0.67A 6ekzA-1gfnA:
0.0		 6ekzA-1gfnA:
12.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gq1 CYTOCHROME CD1
NITRITE REDUCTASE

(Paracoccus
pantotrophus) 		PF02239
(Cytochrom_D1)
PF13442
(Cytochrome_CBB3) 		4 ASP A 255
SER A 207
GLY A 208
VAL A 559
 None
 0.81A 6ekzA-1gq1A:
0.0		 6ekzA-1gq1A:
9.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1izc MACROPHOMATE
SYNTHASE
INTERMOLECULAR
DIELS-ALDERASE

(Macrophoma
commelinae) 		PF03328
(HpcH_HpaI) 		4 GLN A  30
GLY A 204
PHE A 251
VAL A 248
 None
 0.84A 6ekzA-1izcA:
0.0		 6ekzA-1izcA:
14.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jhz PURINE NUCLEOTIDE
SYNTHESIS REPRESSOR

(Escherichia
coli) 		PF13377
(Peripla_BP_3) 		4 ASP A 275
GLN A 292
GLY A 186
GLY A 246
 None
 0.92A 6ekzA-1jhzA:
undetectable		 6ekzA-1jhzA:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lbu MURAMOYL-PENTAPEPTID
E CARBOXYPEPTIDASE

(Streptomyces
albus) 		PF01471
(PG_binding_1)
PF08291
(Peptidase_M15_3) 		4 ASP A  97
SER A  99
GLY A 100
VAL A 140
 None
 0.95A 6ekzA-1lbuA:
undetectable		 6ekzA-1lbuA:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n60 CARBON MONOXIDE
DEHYDROGENASE LARGE
CHAIN

(Oligotropha
carboxidovorans) 		PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2) 		4 GLN B 528
GLY B 760
SER B 572
VAL B 490
 MCN  B4920 (-4.0A)
MCN  B4920 (-3.6A)
MCN  B4920 (-2.6A)
None
 0.72A 6ekzA-1n60B:
0.0		 6ekzA-1n60B:
8.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r6v SUBTILISIN-LIKE
SERINE PROTEASE

(Fervidobacterium
pennivorans) 		PF00082
(Peptidase_S8) 		4 GLN A 452
GLY A 550
SER A 503
GLY A 504
 None
 0.78A 6ekzA-1r6vA:
0.0		 6ekzA-1r6vA:
9.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uas ALPHA-GALACTOSIDASE

(Oryza sativa) 		PF16499
(Melibiase_2)
PF17450
(Melibiase_2_C) 		4 ASP A 201
GLY A 292
GLY A 278
VAL A 276
 None
 0.91A 6ekzA-1uasA:
0.0		 6ekzA-1uasA:
13.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uj2 URIDINE-CYTIDINE
KINASE 2

(Homo sapiens) 		PF00485
(PRK) 		4 GLY A 211
SER A  31
GLY A  32
VAL A  36
 None
ADP  A2302 (-3.2A)
ADP  A2302 (-3.3A)
None
 0.77A 6ekzA-1uj2A:
undetectable		 6ekzA-1uj2A:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vg0 RAB PROTEINS
GERANYLGERANYLTRANSF
ERASE COMPONENT A 1

(Rattus
norvegicus) 		PF00996
(GDI) 		4 ASP A 277
GLN A 270
GLY A 363
SER A 274
 None
 0.97A 6ekzA-1vg0A:
undetectable		 6ekzA-1vg0A:
9.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vrg PROPIONYL-COA
CARBOXYLASE, BETA
SUBUNIT

(Thermotoga
maritima) 		PF01039
(Carboxyl_trans) 		4 GLY A  75
SER A 130
GLY A 100
VAL A  97
 None
 0.91A 6ekzA-1vrgA:
undetectable		 6ekzA-1vrgA:
10.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w36 EXODEOXYRIBONUCLEASE
V GAMMA CHAIN

(Escherichia
coli) 		PF04257
(Exonuc_V_gamma) 		4 ASP C 906
GLY C 527
PHE C 526
GLY C 501
 None
 0.80A 6ekzA-1w36C:
undetectable		 6ekzA-1w36C:
6.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x0u HYPOTHETICAL
METHYLMALONYL-COA
DECARBOXYLASE ALPHA
SUBUNIT

(Sulfurisphaera
tokodaii) 		PF01039
(Carboxyl_trans) 		4 GLY A  81
SER A 136
GLY A 106
VAL A 103
 None
 0.92A 6ekzA-1x0uA:
undetectable		 6ekzA-1x0uA:
11.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a7n L(+)-MANDELATE
DEHYDROGENASE

(Pseudomonas
putida;
Spinacia
oleracea) 		PF01070
(FMN_dh) 		4 ASP A 168
GLY A 257
GLY A  30
VAL A  37
 None
 0.92A 6ekzA-2a7nA:
undetectable		 6ekzA-2a7nA:
10.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a8x DIHYDROLIPOYL
DEHYDROGENASE

(Mycobacterium
tuberculosis) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		4 ASP A 390
GLN A 352
SER A 392
GLY A 393
 None
 0.49A 6ekzA-2a8xA:
undetectable		 6ekzA-2a8xA:
10.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eh6 ACETYLORNITHINE
AMINOTRANSFERASE

(Aquifex
aeolicus) 		PF00202
(Aminotran_3) 		4 GLN A 215
GLY A 222
GLY A 318
VAL A 295
 PLP  A1001 (-4.3A)
None
None
None
 0.89A 6ekzA-2eh6A:
undetectable		 6ekzA-2eh6A:
13.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f5x BUGD

(Bordetella
pertussis) 		PF03401
(TctC) 		4 GLN A 287
GLY A 136
SER A  73
GLY A  71
 None
 0.72A 6ekzA-2f5xA:
undetectable		 6ekzA-2f5xA:
15.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gmh ELECTRON TRANSFER
FLAVOPROTEIN-UBIQUIN
ONE OXIDOREDUCTASE

(Sus scrofa) 		PF05187
(ETF_QO)
PF13450
(NAD_binding_8) 		4 ASP A 459
GLY A 272
GLY A 293
VAL A 291
 None
UQ5  A 612 (-3.3A)
None
UQ5  A 612 ( 4.9A)
 0.98A 6ekzA-2gmhA:
undetectable		 6ekzA-2gmhA:
9.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hg4 6-DEOXYERYTHRONOLIDE
B SYNTHASE

(Saccharopolyspora
erythraea) 		PF00109
(ketoacyl-synt)
PF00698
(Acyl_transf_1)
PF02801
(Ketoacyl-synt_C)
PF08990
(Docking)
PF16197
(KAsynt_C_assoc) 		4 GLY A 224
SER A 201
GLY A 202
VAL A 381
 None
 0.88A 6ekzA-2hg4A:
undetectable		 6ekzA-2hg4A:
6.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jfe CYTOSOLIC
BETA-GLUCOSIDASE

(Homo sapiens) 		PF00232
(Glyco_hydro_1) 		4 ASP X  62
GLY X  20
SER X  55
GLY X  54
 None
 0.80A 6ekzA-2jfeX:
undetectable		 6ekzA-2jfeX:
10.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o5n MUHV1GPM153

(Murid
betaherpesvirus
1) 		PF11624
(M157) 		4 ASP A 178
GLY A  11
SER A 261
GLY A 262
 None
 0.95A 6ekzA-2o5nA:
undetectable		 6ekzA-2o5nA:
15.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oda HYPOTHETICAL PROTEIN
PSPTO_2114

(Pseudomonas
syringae group
genomosp. 3) 		no annotation 4 ASP A  59
GLY A  21
SER A  14
GLY A  15
 None
 0.57A 6ekzA-2odaA:
undetectable		 6ekzA-2odaA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p87 PRE-MRNA-SPLICING
FACTOR PRP8

(Caenorhabditis
elegans) 		PF01398
(JAB)
PF08084
(PROCT) 		4 GLY A2231
SER A2226
GLY A2227
VAL A2186
 None
 0.94A 6ekzA-2p87A:
undetectable		 6ekzA-2p87A:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p8e PPM1B BETA ISOFORM
VARIANT 6

(Homo sapiens) 		PF00481
(PP2C) 		4 ASP A 128
GLY A  61
SER A 130
GLY A 131
 None
 0.85A 6ekzA-2p8eA:
undetectable		 6ekzA-2p8eA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q09 IMIDAZOLONEPROPIONAS
E

(unidentified) 		PF01979
(Amidohydro_1) 		4 GLN A 363
GLY A 402
GLY A  37
VAL A  34
 None
 0.94A 6ekzA-2q09A:
undetectable		 6ekzA-2q09A:
16.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r9q 2'-DEOXYCYTIDINE
5'-TRIPHOSPHATE
DEAMINASE

(Agrobacterium
fabrum) 		PF06559
(DCD) 		4 ASP A 232
GLY A  49
SER A 162
GLY A 161
 None
 0.95A 6ekzA-2r9qA:
undetectable		 6ekzA-2r9qA:
13.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v3s SERINE/THREONINE-PRO
TEIN KINASE OSR1

(Homo sapiens) 		PF12202
(OSR1_C) 		4 ASP A 478
GLY A 509
SER A 505
GLY A 506
 None
 0.83A 6ekzA-2v3sA:
undetectable		 6ekzA-2v3sA:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vbt RIBOFLAVIN KINASE

(Methanocaldococcus
jannaschii) 		PF01982
(CTP-dep_RFKase) 		4 ASP A 122
GLY A  16
SER A  13
GLY A  14
 None
CDP  A1137 ( 3.2A)
None
CDP  A1137 (-3.6A)
 0.90A 6ekzA-2vbtA:
undetectable		 6ekzA-2vbtA:
18.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2yp1 AROMATIC
PEROXYGENASE

(Agrocybe
aegerita) 		PF01328
(Peroxidase_2) 		7 ASP A  70
GLN A  72
GLY A 195
PHE A 199
SER A 240
GLY A 241
VAL A 244
 None
None
None
HEM  A 350 ( 4.8A)
None
None
None
 0.50A 6ekzA-2yp1A:
56.6		 6ekzA-2yp1A:
96.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bs8 GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE

(Bacillus
subtilis) 		PF00202
(Aminotran_3) 		4 ASP A 412
GLY A  42
SER A  45
GLY A  44
 None
 0.84A 6ekzA-3bs8A:
undetectable		 6ekzA-3bs8A:
11.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3btp SINGLE-STRAND
DNA-BINDING PROTEIN
PROTEIN VIRE1

(Agrobacterium
fabrum;
Agrobacterium
fabrum) 		PF07229
(VirE2)
PF12189
(VirE1) 		4 ASP B  40
GLY A 257
SER A 311
GLY A 312
 None
 0.90A 6ekzA-3btpB:
undetectable		 6ekzA-3btpB:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dfh MANDELATE RACEMASE

(Vibrionales
bacterium
SWAT-3) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 GLN A 285
GLY A  38
SER A  93
GLY A  94
VAL A  26
 None
 1.17A 6ekzA-3dfhA:
undetectable		 6ekzA-3dfhA:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e7q TRANSCRIPTIONAL
REGULATOR

(Pseudomonas
aeruginosa) 		PF00440
(TetR_N)
PF13977
(TetR_C_6) 		4 GLN A  33
GLY A 127
SER A 122
GLY A 121
 None
 0.70A 6ekzA-3e7qA:
undetectable		 6ekzA-3e7qA:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ek1 ALDEHYDE
DEHYDROGENASE

(Brucella
abortus) 		PF00171
(Aldedh) 		4 ASP A  36
GLY A  41
SER A  38
VAL A  31
 None
 0.86A 6ekzA-3ek1A:
undetectable		 6ekzA-3ek1A:
12.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fcy XYLAN ESTERASE 1

(Thermoanaerobacterium
saccharolyticum) 		PF05448
(AXE1) 		4 ASP A 115
GLN A 122
SER A  95
GLY A  96
 None
 0.70A 6ekzA-3fcyA:
undetectable		 6ekzA-3fcyA:
12.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gir AMINOMETHYLTRANSFERA
SE

(Bartonella
henselae) 		PF01571
(GCV_T)
PF08669
(GCV_T_C) 		4 ASP A 245
GLY A 321
SER A 319
VAL A 330
 None
 0.95A 6ekzA-3girA:
undetectable		 6ekzA-3girA:
12.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h1v GLUCOKINASE

(Homo sapiens) 		PF00349
(Hexokinase_1)
PF03727
(Hexokinase_2) 		4 ASP X 205
GLY X 295
GLY X 227
VAL X 412
 GLC  X 500 (-2.9A)
None
None
None
 0.97A 6ekzA-3h1vX:
undetectable		 6ekzA-3h1vX:
10.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hdj PROBABLE ORNITHINE
CYCLODEAMINASE

(Bordetella
pertussis) 		PF02423
(OCD_Mu_crystall) 		4 GLN A  19
GLY A 207
PHE A 205
VAL A 185
 None
 0.96A 6ekzA-3hdjA:
undetectable		 6ekzA-3hdjA:
16.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hvn HEMOLYSIN

(Streptococcus
suis) 		PF01289
(Thiol_cytolysin)
PF17440
(Thiol_cytolys_C) 		4 GLN A 177
GLY A 321
GLY A 271
VAL A 355
 None
 0.72A 6ekzA-3hvnA:
undetectable		 6ekzA-3hvnA:
10.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jr3 NAD-DEPENDENT
DEACETYLASE

(Thermotoga
maritima) 		PF02146
(SIR2) 		4 ASP A 101
GLY A 188
SER A  25
VAL A 232
 None
 0.97A 6ekzA-3jr3A:
undetectable		 6ekzA-3jr3A:
13.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nsj PERFORIN-1

(Mus musculus) 		PF00168
(C2)
PF01823
(MACPF) 		4 GLN A 410
GLY A 475
PHE A 442
GLY A 443
 IOD  A 712 (-4.4A)
None
None
None
 0.93A 6ekzA-3nsjA:
undetectable		 6ekzA-3nsjA:
9.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nxk CYTOPLASMIC
L-ASPARAGINASE

(Campylobacter
jejuni) 		PF00710
(Asparaginase) 		4 ASP A 229
GLY A 254
SER A 225
VAL A 276
 None
 0.93A 6ekzA-3nxkA:
undetectable		 6ekzA-3nxkA:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qfh EPIDERMIN LEADER
PEPTIDE PROCESSING
SERINE PROTEASE EPIP

(Staphylococcus
aureus) 		PF00082
(Peptidase_S8) 		4 GLY A 166
SER A 218
GLY A 217
VAL A 162
 None
 0.95A 6ekzA-3qfhA:
undetectable		 6ekzA-3qfhA:
10.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qs3 FIMBRILLIN MATB
HOMOLOG, ECPD

(Escherichia
coli) 		PF16449
(MatB) 		4 ASP A  77
GLY A 144
SER A  79
GLY A  80
 None
 0.80A 6ekzA-3qs3A:
undetectable		 6ekzA-3qs3A:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v9e LACCASE

(Botrytis aclada) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 ASP A 167
GLN A 166
GLY A 269
SER A 237
 None
None
GOL  A 607 (-3.3A)
None
 0.97A 6ekzA-3v9eA:
undetectable		 6ekzA-3v9eA:
9.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vkg DYNEIN HEAVY CHAIN,
CYTOPLASMIC

(Dictyostelium
discoideum) 		PF03028
(Dynein_heavy)
PF07728
(AAA_5)
PF08393
(DHC_N2)
PF12774
(AAA_6)
PF12775
(AAA_7)
PF12777
(MT)
PF12780
(AAA_8)
PF12781
(AAA_9) 		4 GLN A1962
GLY A2072
PHE A2074
GLY A1969
 None
 0.77A 6ekzA-3vkgA:
undetectable		 6ekzA-3vkgA:
2.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vsv XYLOSIDASE

(Thermoanaerobacterium
saccharolyticum) 		PF13229
(Beta_helix) 		4 ASP A 214
GLY A 329
GLY A 307
VAL A 331
 None
 0.66A 6ekzA-3vsvA:
undetectable		 6ekzA-3vsvA:
9.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w9i MULTIDRUG RESISTANCE
PROTEIN MEXB

(Pseudomonas
aeruginosa) 		PF00873
(ACR_tran) 		4 ASP A  85
GLY A 625
GLY A 614
VAL A 612
 None
 0.92A 6ekzA-3w9iA:
undetectable		 6ekzA-3w9iA:
6.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wxr PROBABLE PROTEASOME
SUBUNIT ALPHA TYPE-7

(Saccharomyces
cerevisiae) 		PF00227
(Proteasome)
PF10584
(Proteasome_A_N) 		4 GLY G 116
SER G 155
GLY G 154
VAL G 119
 None
 0.94A 6ekzA-3wxrG:
undetectable		 6ekzA-3wxrG:
16.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zyv AOX3

(Mus musculus) 		PF00111
(Fer2)
PF00941
(FAD_binding_5)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2)
PF03450
(CO_deh_flav_C) 		4 ASP A1239
GLN A 434
GLY A 149
SER A1236
 None
 0.73A 6ekzA-3zyvA:
undetectable		 6ekzA-3zyvA:
4.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a7l MYOSIN IE HEAVY
CHAIN

(Dictyostelium
discoideum) 		PF00063
(Myosin_head) 		4 GLN C 411
GLY C 389
SER C 100
GLY C 101
 None
 0.89A 6ekzA-4a7lC:
undetectable		 6ekzA-4a7lC:
8.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ade SUCCINYLORNITHINE
TRANSAMINASE

(Escherichia
coli) 		PF00202
(Aminotran_3) 		4 GLN A 226
GLY A 233
GLY A 336
VAL A 308
 None
 0.86A 6ekzA-4adeA:
undetectable		 6ekzA-4adeA:
11.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bp8 OLIGOPEPTIDASE B

(Trypanosoma
brucei) 		PF00326
(Peptidase_S9)
PF02897
(Peptidase_S9_N) 		4 GLN A 699
GLY A 570
GLY A 566
VAL A 590
 None
 0.86A 6ekzA-4bp8A:
undetectable		 6ekzA-4bp8A:
8.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c22 L-FUCOSE ISOMERASE

(Streptococcus
pneumoniae) 		PF02952
(Fucose_iso_C)
PF07881
(Fucose_iso_N1)
PF07882
(Fucose_iso_N2) 		4 GLN A 257
GLY A 299
PHE A 297
GLY A 310
 None
 0.94A 6ekzA-4c22A:
undetectable		 6ekzA-4c22A:
9.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c3s ALDEHYDE
DEHYDROGENASE

(Lachnoclostridium
phytofermentans) 		PF00171
(Aldedh) 		4 GLY A 347
PHE A 345
GLY A 364
VAL A 366
 None
 0.86A 6ekzA-4c3sA:
undetectable		 6ekzA-4c3sA:
11.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cj0 ENDOGLUCANASE D

(Ruminiclostridium
thermocellum) 		PF00759
(Glyco_hydro_9)
PF02927
(CelD_N) 		4 ASP A 262
PHE A 334
SER A 264
GLY A 265
 None
 0.96A 6ekzA-4cj0A:
undetectable		 6ekzA-4cj0A:
9.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ewt PEPTIDASE,
M20/M25/M40 FAMILY

(Staphylococcus
aureus) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		4 GLY A 197
SER A 200
GLY A 199
VAL A 248
 None
 0.77A 6ekzA-4ewtA:
undetectable		 6ekzA-4ewtA:
12.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f1r CATABOLITE
REPRESSION CONTROL
PROTEIN

(Pseudomonas
aeruginosa) 		PF03372
(Exo_endo_phos) 		4 ASP A 220
GLY A 216
SER A 202
VAL A 158
 None
 0.97A 6ekzA-4f1rA:
undetectable		 6ekzA-4f1rA:
12.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f6o METACASPASE-1

(Saccharomyces
cerevisiae) 		PF00656
(Peptidase_C14) 		4 ASP A 158
GLY A 221
SER A 218
GLY A 219
 None
 0.83A 6ekzA-4f6oA:
undetectable		 6ekzA-4f6oA:
15.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gvr METHENYLTETRAHYDROME
THANOPTERIN
CYCLOHYDROLASE

(Archaeoglobus
fulgidus) 		PF02289
(MCH) 		4 GLY A  39
SER A  45
GLY A  44
VAL A  42
 None
 0.76A 6ekzA-4gvrA:
undetectable		 6ekzA-4gvrA:
13.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i0w PROTEASE CSPB

(Clostridium
perfringens) 		PF00082
(Peptidase_S8) 		4 ASP B 370
GLN B 372
SER B 263
GLY B 262
 None
 0.87A 6ekzA-4i0wB:
undetectable		 6ekzA-4i0wB:
12.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4igl YENB

(Yersinia
entomophaga) 		PF03534
(SpvB)
PF12255
(TcdB_toxin_midC)
PF12256
(TcdB_toxin_midN) 		4 ASP A 625
GLY A 573
SER A 627
GLY A 628
 K  A1503 (-3.1A)
None
K  A1503 (-2.8A)
None
 0.78A 6ekzA-4iglA:
undetectable		 6ekzA-4iglA:
5.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j34 KYNURENINE
3-MONOOXYGENASE

(Saccharomyces
cerevisiae) 		PF01494
(FAD_binding_3) 		4 GLN A 325
GLY A 313
GLY A 330
VAL A  13
 FAD  A 401 (-4.4A)
FAD  A 401 (-3.6A)
None
FAD  A 401 (-3.7A)
 0.92A 6ekzA-4j34A:
undetectable		 6ekzA-4j34A:
10.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kvf RHAMNOSE ABC
TRANSPORTER,
PERIPLASMIC
RHAMNOSE-BINDING
PROTEIN

(Kribbella
flavida) 		PF13407
(Peripla_BP_4) 		4 ASP A 151
GLY A 323
GLY A 343
VAL A 339
 None
 0.83A 6ekzA-4kvfA:
undetectable		 6ekzA-4kvfA:
13.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lxi MCP HYDROLASE

(Sphingomonas
wittichii) 		PF12697
(Abhydrolase_6) 		4 GLN A 268
GLY A 129
GLY A 223
VAL A 235
 None
 0.91A 6ekzA-4lxiA:
undetectable		 6ekzA-4lxiA:
15.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mtn TRANSCRIPTION
TERMINATION FACTOR
NUSA

(Planctopirus
limnophila) 		PF00575
(S1)
PF08529
(NusA_N)
PF13184
(KH_5)
PF14520
(HHH_5) 		4 GLY A   3
SER A  54
GLY A  55
VAL A   6
 None
 0.81A 6ekzA-4mtnA:
undetectable		 6ekzA-4mtnA:
14.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ql6 CARBOXY-TERMINAL
PROCESSING PROTEASE

(Chlamydia
trachomatis) 		PF00595
(PDZ)
PF03572
(Peptidase_S41) 		4 ASP A 466
GLN A 465
SER A 510
GLY A 511
 None
 0.94A 6ekzA-4ql6A:
undetectable		 6ekzA-4ql6A:
8.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ywo MERCURIC REDUCTASE

(Metallosphaera
sedula) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		4 GLN A 103
PHE A  14
GLY A  36
VAL A  40
 None
 0.95A 6ekzA-4ywoA:
undetectable		 6ekzA-4ywoA:
11.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yzg PROTEIN PHOSPHATASE
2C 57

(Arabidopsis
thaliana) 		PF00481
(PP2C) 		4 ASP A 157
GLY A  94
SER A 159
GLY A 160
 None
MN  A 401 (-4.2A)
None
None
 0.69A 6ekzA-4yzgA:
undetectable		 6ekzA-4yzgA:
14.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z42 UREASE SUBUNIT ALPHA

(Yersinia
enterocolitica) 		PF00449
(Urease_alpha)
PF01979
(Amidohydro_1) 		4 ASP C  88
GLY C  56
SER C 102
GLY C 103
 None
 0.92A 6ekzA-4z42C:
undetectable		 6ekzA-4z42C:
8.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zlg PUTATIVE B-GLYCAN
PHOSPHORYLASE

(Saccharophagus
degradans) 		PF06165
(Glyco_transf_36)
PF17167
(Glyco_hydro_36) 		4 ASP A 469
GLY A 537
SER A 485
GLY A 486
 None
 0.97A 6ekzA-4zlgA:
undetectable		 6ekzA-4zlgA:
7.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cag UNCHARACTERIZED
PROTEIN

(Bacteroides
ovatus) 		PF17145
(DUF5119) 		4 PHE A 204
SER A 180
GLY A 179
VAL A 177
 None
 0.95A 6ekzA-5cagA:
undetectable		 6ekzA-5cagA:
13.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cxc RIBOSOME BIOGENESIS
PROTEIN ERB1

(Chaetomium
thermophilum) 		PF00400
(WD40) 		4 GLY B 775
SER B 741
GLY B 740
VAL B 770
 None
 0.54A 6ekzA-5cxcB:
undetectable		 6ekzA-5cxcB:
12.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d6h CSUC

(Acinetobacter
baumannii) 		PF00345
(PapD_N) 		4 ASP A 225
GLY A 130
SER A 227
GLY A 228
 None
 0.93A 6ekzA-5d6hA:
undetectable		 6ekzA-5d6hA:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dcf TYROSINE RECOMBINASE
XERD,DNA TRANSLOCASE
FTSK

(Escherichia
coli) 		PF00589
(Phage_integrase)
PF09397
(Ftsk_gamma) 		4 ASP A 151
GLY A  56
GLY A  73
VAL A  77
 None
 0.92A 6ekzA-5dcfA:
undetectable		 6ekzA-5dcfA:
15.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ekp UNCHARACTERIZED
GLYCOSYLTRANSFERASE
SLL0501

(Synechocystis
sp. PCC 6803) 		no annotation 4 GLY C 181
PHE C 223
SER C 222
GLY C 219
 None
 0.87A 6ekzA-5ekpC:
undetectable		 6ekzA-5ekpC:
14.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gsl 778AA LONG
HYPOTHETICAL
BETA-GALACTOSIDASE

(Pyrococcus
horikoshii) 		PF02449
(Glyco_hydro_42) 		5 GLN A 648
GLY A 624
PHE A 625
GLY A 610
VAL A 595
 None
 1.20A 6ekzA-5gslA:
undetectable		 6ekzA-5gslA:
8.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h2t TREHALOSE SYNTHASE

(Thermomonospora
curvata) 		no annotation 5 ASP A  42
GLY A  35
PHE A 425
GLY A  45
VAL A  33
 None
 1.13A 6ekzA-5h2tA:
undetectable		 6ekzA-5h2tA:
6.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h67 CHROMOSOME PARTITION
PROTEIN SMC
CHROMOSOME PARTITION
PROTEIN SMC

(Bacillus
subtilis;
Bacillus
subtilis) 		PF02463
(SMC_N)
PF02463
(SMC_N) 		4 ASP B1117
GLN A 143
GLY A  34
SER A  38
 None
None
ATP  A1001 (-3.4A)
ATP  A1001 (-4.5A)
 0.90A 6ekzA-5h67B:
undetectable		 6ekzA-5h67B:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h8y SULFITE REDUCTASE
[FERREDOXIN],
CHLOROPLASTIC

(Zea mays) 		PF01077
(NIR_SIR)
PF03460
(NIR_SIR_ferr) 		4 ASP A 295
GLN A 355
GLY A 320
GLY A 318
 None
None
SRM  A 702 (-3.5A)
SRM  A 702 (-3.7A)
 0.90A 6ekzA-5h8yA:
undetectable		 6ekzA-5h8yA:
9.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i5j NITROUS-OXIDE
REDUCTASE

(Shewanella
denitrificans) 		no annotation 4 ASP A 434
SER A 135
GLY A 134
VAL A 181
 None
 0.78A 6ekzA-5i5jA:
undetectable		 6ekzA-5i5jA:
9.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5inf CARBOXYL TRANSFERASE

(Streptomyces
ambofaciens) 		PF01039
(Carboxyl_trans) 		4 GLN A 386
GLY A 421
GLY A 379
VAL A 377
 None
 0.78A 6ekzA-5infA:
undetectable		 6ekzA-5infA:
10.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iql YEATS
DOMAIN-CONTAINING
PROTEIN 2

(Homo sapiens) 		PF03366
(YEATS) 		4 ASP A 228
GLY A 283
SER A 230
GLY A 281
 None
 0.88A 6ekzA-5iqlA:
undetectable		 6ekzA-5iqlA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jow NON-REDUCING END
ALPHA-L-ARABINOFURAN
OSIDASE BOGH43A

(Bacteroides
ovatus) 		PF04616
(Glyco_hydro_43) 		4 GLN A 342
GLY A 490
SER A  90
GLY A  89
 None
EDO  A 611 (-3.9A)
None
None
 0.98A 6ekzA-5jowA:
undetectable		 6ekzA-5jowA:
9.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mjs TUBULIN ALPHA-1
CHAIN

(Schizosaccharomyces
pombe) 		no annotation 4 GLN E  11
GLY E 152
SER E 104
GLY E 148
 GTP  E 500 (-2.8A)
None
GTP  E 500 (-2.2A)
GTP  E 500 (-3.2A)
 0.92A 6ekzA-5mjsE:
undetectable		 6ekzA-5mjsE:
15.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oup PERFORIN-LIKE
PROTEIN 1

(Toxoplasma
gondii) 		no annotation 4 GLN A 554
GLY A 472
GLY A 470
VAL A 496
 None
 0.65A 6ekzA-5oupA:
undetectable		 6ekzA-5oupA:
17.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5sui RIBOSOME BIOGENESIS
PROTEIN NSA1

(Saccharomyces
cerevisiae) 		no annotation 4 ASP A 143
GLY A 187
SER A 166
GLY A 167
 None
 0.70A 6ekzA-5suiA:
undetectable		 6ekzA-5suiA:
11.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x68 KYNURENINE
3-MONOOXYGENASE

(Homo sapiens) 		no annotation 4 GLN A 315
GLY A 303
GLY A 320
VAL A  19
 FAD  A 401 (-4.3A)
FAD  A 401 (-3.4A)
None
FAD  A 401 (-3.5A)
 0.93A 6ekzA-5x68A:
undetectable		 6ekzA-5x68A:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x7h CYCLOISOMALTOOLIGOSA
CCHARIDE
GLUCANOTRANSFERASE

(Paenibacillus
sp. 598K) 		PF13199
(Glyco_hydro_66)
PF16990
(CBM_35) 		4 ASP A 174
GLN A 173
GLY A 133
VAL A  45
 None
 0.82A 6ekzA-5x7hA:
undetectable		 6ekzA-5x7hA:
7.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xr6 RAS-RELATED PROTEIN
RABA1A

(Arabidopsis
thaliana) 		no annotation 4 ASP A 159
GLY A 125
SER A 156
VAL A  95
 None
None
GNP  A 301 (-3.3A)
None
 0.97A 6ekzA-5xr6A:
undetectable		 6ekzA-5xr6A:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ay4 CYP51, STEROL
14ALPHA-DEMETHYLASE

(Naegleria
fowleri) 		no annotation 4 GLN A 238
GLY A 115
GLY A 285
VAL A 118
 None
 0.90A 6ekzA-6ay4A:
undetectable		 6ekzA-6ay4A:
10.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bog RNA
POLYMERASE-ASSOCIATE
D PROTEIN RAPA

(Escherichia
coli) 		no annotation 4 ASP A 789
PHE A 108
SER A 793
GLY A 794
 None
 0.96A 6ekzA-6bogA:
undetectable		 6ekzA-6bogA:
15.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ckc METHYLOSOME PROTEIN
50

(Homo sapiens) 		no annotation 4 ASP B 180
SER B 136
GLY B 137
VAL B  89
 None
 0.62A 6ekzA-6ckcB:
undetectable		 6ekzA-6ckcB:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dft


(;
) 		no annotation
no annotation 		4 ASP B 316
GLY B 134
PHE B 118
GLY A 403
 NAD  B 500 (-3.6A)
None
None
None
 0.86A 6ekzA-6dftB:
undetectable		 6ekzA-6dftB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6en4 SPLICING FACTOR 3B
SUBUNIT 1

(Homo sapiens) 		no annotation 4 ASP C 953
SER C 992
GLY C 991
VAL C1031
 None
 0.95A 6ekzA-6en4C:
undetectable		 6ekzA-6en4C:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f34 AMINO ACID
TRANSPORTER

(Geobacillus
kaustophilus) 		no annotation 4 ASP A 159
GLY A 133
SER A 128
GLY A 129
 None
 0.88A 6ekzA-6f34A:
undetectable		 6ekzA-6f34A:
24.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gne -

(-) 		no annotation 4 ASP A  91
SER A 205
GLY A 204
VAL A 210
 None
 0.79A 6ekzA-6gneA:
undetectable		 6ekzA-6gneA:
undetectable