SIMILAR PATTERNS OF AMINO ACIDS FOR 6EID_A_EDTA1111

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zb8 PCURE2P6

(Phanerochaete
chrysosporium) 		PF00043
(GST_C)
PF02798
(GST_N) 		4 GLN A 114
ASN A 176
PHE A 189
TYR A 118
 None
 1.42A 6eidA-4zb8A:
0.0		 6eidA-4zb8A:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5szn PROTOCADHERIN GAMMA
A9

(Mus musculus) 		PF00028
(Cadherin)
PF08266
(Cadherin_2) 		4 GLN A 498
ASN A 499
PHE A 523
TYR A 494
 None
 1.31A 6eidA-5sznA:
undetectable		 6eidA-5sznA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eid ARCHAEAL-TYPE OPSIN
2

(Chlamydomonas
reinhardtii) 		no annotation 4 GLN A  49
ASN A  53
PHE A  98
TYR A 243
 EDT  A1111 (-4.1A)
EDT  A1111 (-2.6A)
EDT  A1111 (-4.1A)
EDT  A1111 (-4.7A)
 0.00A 6eidA-6eidA:
42.8		 6eidA-6eidA:
undetectable