SIMILAR PATTERNS OF AMINO ACIDS FOR 6EFN_A_SAMA501

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c0n PROTEIN (CSDB
PROTEIN)

(Escherichia
coli) 		PF00266
(Aminotran_5) 		5 GLU A 390
SER A  29
ALA A  33
LEU A 299
ALA A 303
 None
 1.31A 6efnA-1c0nA:
undetectable		 6efnA-1c0nA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gso PROTEIN (GLYCINAMIDE
RIBONUCLEOTIDE
SYNTHETASE)

(Escherichia
coli) 		PF01071
(GARS_A)
PF02843
(GARS_C)
PF02844
(GARS_N) 		5 TYR A 266
PHE A  92
ARG A  85
ALA A 314
ALA A 260
 None
 1.29A 6efnA-1gsoA:
undetectable		 6efnA-1gsoA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iay 1-AMINOCYCLOPROPANE-
1-CARBOXYLATE
SYNTHASE 2

(Solanum
lycopersicum) 		PF00155
(Aminotran_1_2) 		5 TYR A 274
THR A 109
GLU A 255
ALA A 362
ALA A 127
 None
None
None
None
PLP  A 500 (-2.9A)
 1.46A 6efnA-1iayA:
undetectable		 6efnA-1iayA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ka0 HALOTOLERANCE
PROTEIN HAL2

(Saccharomyces
cerevisiae) 		PF00459
(Inositol_P) 		5 TYR A 183
SER A 264
ALA A 157
LEU A 273
ALA A 276
 None
 1.38A 6efnA-1ka0A:
undetectable		 6efnA-1ka0A:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l1l RIBONUCLEOSIDE
TRIPHOSPHATE
REDUCTASE

(Lactobacillus
leichmannii) 		PF02867
(Ribonuc_red_lgC) 		5 GLU A 423
SER A 648
THR A 650
THR A 652
ALA A 623
 None
 1.46A 6efnA-1l1lA:
3.1		 6efnA-1l1lA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mc3 GLUCOSE-1-PHOSPHATE
THYMIDYLYLTRANSFERAS
E

(Escherichia
coli) 		PF00483
(NTP_transferase) 		5 TYR A 204
PHE A  90
SER A 102
THR A 131
LEU A 210
 None
 1.48A 6efnA-1mc3A:
undetectable		 6efnA-1mc3A:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qxp MU-LIKE CALPAIN

(Bos taurus;
Rattus
norvegicus) 		PF00648
(Peptidase_C2)
PF01067
(Calpain_III)
PF13833
(EF-hand_8) 		5 THR A 208
PHE A 204
SER A 113
THR A 267
LEU A 232
 None
 1.33A 6efnA-1qxpA:
undetectable		 6efnA-1qxpA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r2j PROTEIN FKBI

(Streptomyces
hygroscopicus) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		5 GLU A 347
SER A  73
ARG A  72
ALA A 189
ALA A 239
 None
 1.46A 6efnA-1r2jA:
undetectable		 6efnA-1r2jA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sq7 TRIOSEPHOSPHATE
ISOMERASE

(Gallus gallus) 		PF00121
(TIM) 		5 THR A  37
PHE A   6
ALA A 221
THR A 213
ALA A 234
 None
 1.07A 6efnA-1sq7A:
7.3		 6efnA-1sq7A:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tpy METHOXY MYCOLIC ACID
SYNTHASE 2

(Mycobacterium
tuberculosis) 		PF02353
(CMAS) 		5 PHE A 142
SER A 135
ALA A 138
THR A 168
THR A 170
 SAH  A1900 (-4.6A)
None
SAH  A1900 (-3.1A)
None
None
 1.47A 6efnA-1tpyA:
undetectable		 6efnA-1tpyA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tqh CARBOXYLESTERASE
PRECURSOR

(Geobacillus
stearothermophilus) 		PF12146
(Hydrolase_4) 		5 THR A 106
ALA A 183
THR A 185
THR A 114
ALA A 117
 None
 1.23A 6efnA-1tqhA:
2.4		 6efnA-1tqhA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wta 5'-METHYLTHIOADENOSI
NE PHOSPHORYLASE

(Aeropyrum
pernix) 		PF01048
(PNP_UDP_1) 		5 SER A  95
ARG A  62
ALA A 215
THR A 213
ALA A 204
 PO4  A 400 (-2.8A)
PO4  A 400 (-3.8A)
None
None
None
 1.40A 6efnA-1wtaA:
undetectable		 6efnA-1wtaA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xg5 ARPG836

(Homo sapiens) 		PF00106
(adh_short) 		5 THR A 203
PHE A 205
ALA A 101
THR A 163
LEU A 158
 NAP  A1301 (-2.6A)
ACY  A1401 ( 3.9A)
None
None
None
 1.44A 6efnA-1xg5A:
2.0		 6efnA-1xg5A:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yqq XANTHOSINE
PHOSPHORYLASE

(Escherichia
coli) 		PF01048
(PNP_UDP_1) 		5 PHE A 188
SER A 216
ARG A  85
THR A 254
ALA A 258
 None
PO4  A 500 (-2.4A)
PO4  A 500 (-4.2A)
GUN  A 400 (-3.4A)
None
 1.41A 6efnA-1yqqA:
undetectable		 6efnA-1yqqA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zki HYPOTHETICAL PROTEIN
PA5202

(Pseudomonas
aeruginosa) 		PF03061
(4HBT) 		5 THR A  76
GLU A  78
ALA A  96
LEU A  20
ALA A  51
 None
 1.38A 6efnA-1zkiA:
undetectable		 6efnA-1zkiA:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bku IMPORTIN BETA-1
SUBUNIT

(Saccharomyces
cerevisiae) 		PF03810
(IBN_N)
PF13513
(HEAT_EZ) 		5 THR B   3
PHE B   6
THR B  64
LEU B 118
ALA B 114
 None
 1.12A 6efnA-2bkuB:
undetectable		 6efnA-2bkuB:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bwp 5-AMINOLEVULINATE
SYNTHASE

(Rhodobacter
capsulatus) 		PF00155
(Aminotran_1_2) 		5 SER A 260
ALA A 259
THR A 211
LEU A 181
ALA A 204
 None
 1.40A 6efnA-2bwpA:
undetectable		 6efnA-2bwpA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fj0 CARBOXYLIC ESTER
HYDROLASE

(Manduca sexta) 		PF00135
(COesterase) 		5 GLU A 357
PHE A 259
SER A 226
ALA A 227
LEU A 308
 None
TFC  A 600 (-4.0A)
TFC  A 600 (-1.4A)
TFC  A 600 (-3.5A)
None
 1.36A 6efnA-2fj0A:
2.2		 6efnA-2fj0A:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gah HETEROTETRAMERIC
SARCOSINE OXIDASE
ALPHA-SUBUNIT

(Stenotrophomonas
maltophilia) 		PF01571
(GCV_T)
PF07992
(Pyr_redox_2)
PF08669
(GCV_T_C)
PF13510
(Fer2_4) 		5 THR A 129
SER A 148
ALA A 194
THR A 188
ALA A 163
 None
 1.49A 6efnA-2gahA:
undetectable		 6efnA-2gahA:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gfq UPF0204 PROTEIN
PH0006

(Pyrococcus
horikoshii) 		PF04414
(tRNA_deacylase) 		5 THR A  94
GLU A 137
PHE A 152
SER A  78
THR A   7
 None
MG  A2018 ( 4.6A)
MG  A2018 ( 4.6A)
MG  A2018 ( 4.8A)
None
 1.43A 6efnA-2gfqA:
undetectable		 6efnA-2gfqA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i9e TRIOSEPHOSPHATE
ISOMERASE

(Tenebrio
molitor) 		PF00121
(TIM) 		5 THR A  36
PHE A   5
ALA A 220
THR A 212
ALA A 233
 None
 1.18A 6efnA-2i9eA:
3.8		 6efnA-2i9eA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pod MANDELATE RACEMASE /
MUCONATE LACTONIZING
ENZYME

(Burkholderia
pseudomallei) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 THR A 323
GLU A 345
SER A 331
ALA A 330
ALA A 273
 None
 1.42A 6efnA-2podA:
5.1		 6efnA-2podA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v82 2-DEHYDRO-3-DEOXY-6-
PHOSPHOGALACTONATE
ALDOLASE

(Escherichia
coli) 		PF01081
(Aldolase) 		5 THR A  86
SER A  91
ALA A 120
THR A 116
THR A 112
 None
 1.42A 6efnA-2v82A:
7.3		 6efnA-2v82A:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vnr CPE0329

(Clostridium
perfringens) 		PF08305
(NPCBM) 		5 PHE A 118
SER A 120
ALA A 201
THR A  98
ALA A 100
 None
 1.40A 6efnA-2vnrA:
undetectable		 6efnA-2vnrA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xfg ENDOGLUCANASE 1

(Ruminiclostridium
thermocellum) 		PF00759
(Glyco_hydro_9) 		5 GLU A 445
PHE A  85
ALA A  77
THR A 321
ALA A 355
 None
 1.36A 6efnA-2xfgA:
undetectable		 6efnA-2xfgA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xsg CCMAN5

(Cellulosimicrobium
cellulans) 		PF07971
(Glyco_hydro_92) 		5 THR A 346
ALA A  32
THR A 253
LEU A 254
ALA A 262
 None
 1.48A 6efnA-2xsgA:
undetectable		 6efnA-2xsgA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xsw 72 KDA INOSITOL
POLYPHOSPHATE
5-PHOSPHATASE

(Homo sapiens) 		PF03372
(Exo_endo_phos) 		5 TYR A 439
THR A 466
SER A 423
ALA A 406
LEU A 437
 None
 1.35A 6efnA-2xswA:
undetectable		 6efnA-2xswA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ygl BLOOD GROUP A-AND
B-CLEAVING
ENDO-BETA-GALACTOSID
ASE

(Streptococcus
pneumoniae) 		PF08305
(NPCBM) 		5 PHE A 324
SER A 326
ALA A 407
THR A 304
ALA A 306
 None
 1.38A 6efnA-2yglA:
undetectable		 6efnA-2yglA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ztb CRYSTAL PROTEIN

(Bacillus
thuringiensis) 		PF03318
(ETX_MTX2) 		5 PHE A 182
SER A 232
ALA A 233
THR A 279
THR A 163
 None
 1.41A 6efnA-2ztbA:
undetectable		 6efnA-2ztbA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ahm OLIGOPEPTIDASE

(Geobacillus sp.
MO-1) 		no annotation 5 GLU A 231
ALA A 221
THR A 379
LEU A 380
ALA A 382
 None
 1.24A 6efnA-3ahmA:
undetectable		 6efnA-3ahmA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c87 ENTEROCHELIN
ESTERASE

(Shigella
flexneri) 		PF00756
(Esterase)
PF11806
(DUF3327) 		5 TYR A 229
THR A 219
GLU A 162
ALA A 191
LEU A 196
 None
 1.33A 6efnA-3c87A:
undetectable		 6efnA-3c87A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cx3 LIPOPROTEIN

(Streptococcus
pneumoniae) 		PF01297
(ZnuA) 		5 GLU A 234
SER A 265
ALA A 268
THR A 259
THR A 281
 None
 1.45A 6efnA-3cx3A:
undetectable		 6efnA-3cx3A:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3du4 ADENOSYLMETHIONINE-8
-AMINO-7-OXONONANOAT
E AMINOTRANSFERASE

(Bacillus
subtilis) 		PF00202
(Aminotran_3) 		5 THR A 150
SER A 110
ALA A 290
THR A 292
ALA A 124
 None
 1.13A 6efnA-3du4A:
undetectable		 6efnA-3du4A:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e2d ALKALINE PHOSPHATASE

(Vibrio sp.
G15-21) 		PF00245
(Alk_phosphatase) 		5 SER A  65
ARG A 129
ALA A  69
THR A 115
LEU A 114
 ZN  A 602 (-3.5A)
SO4  A 610 (-3.0A)
None
None
None
 1.26A 6efnA-3e2dA:
undetectable		 6efnA-3e2dA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3egw RESPIRATORY NITRATE
REDUCTASE 1 ALPHA
CHAIN
RESPIRATORY NITRATE
REDUCTASE 1 BETA
CHAIN

(Escherichia
coli;
Escherichia
coli) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF14710
(Nitr_red_alph_N)
PF13247
(Fer4_11)
PF14711
(Nitr_red_bet_C) 		5 SER A1099
ARG A 774
ALA A1164
LEU A1171
ALA B 124
 MD1  A1245 (-2.7A)
MD1  A1245 (-3.8A)
None
None
None
 1.14A 6efnA-3egwA:
undetectable		 6efnA-3egwA:
15.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fge PUTATIVE FLAVIN
REDUCTASE WITH SPLIT
BARREL DOMAIN

(Shewanella
frigidimarina) 		PF01613
(Flavin_Reduct) 		5 TYR A 118
THR A  41
GLU A 110
PHE A 109
LEU A 119
 None
 1.40A 6efnA-3fgeA:
undetectable		 6efnA-3fgeA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hm7 ALLANTOINASE

(Bacillus
halodurans) 		PF01979
(Amidohydro_1) 		5 THR A 328
PHE A 330
ARG A 205
ALA A 214
LEU A 275
 None
 1.45A 6efnA-3hm7A:
5.3		 6efnA-3hm7A:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ht1 REMF PROTEIN

(Streptomyces
resistomycificus) 		PF07883
(Cupin_2) 		5 THR A 104
GLU A  21
ALA A  11
THR A  40
LEU A 108
 None
 1.34A 6efnA-3ht1A:
undetectable		 6efnA-3ht1A:
14.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i45 TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL
PROTEIN

(Rhodospirillum
rubrum) 		PF13458
(Peripla_BP_6) 		5 THR A 147
PHE A 204
ALA A 130
THR A 126
THR A 107
 None
 1.26A 6efnA-3i45A:
2.4		 6efnA-3i45A:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k7x LIN0763 PROTEIN

(Listeria
innocua) 		PF03663
(Glyco_hydro_76) 		5 GLU A 258
SER A 245
THR A 241
LEU A 223
ALA A 221
 None
 1.42A 6efnA-3k7xA:
undetectable		 6efnA-3k7xA:
24.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3myr HYDROGENASE (NIFE)
SMALL SUBUNIT HYDA

(Allochromatium
vinosum) 		PF01058
(Oxidored_q6)
PF14720
(NiFe_hyd_SSU_C) 		5 TYR A  43
PHE A  13
THR A 102
LEU A  60
ALA A  62
 None
 1.13A 6efnA-3myrA:
undetectable		 6efnA-3myrA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nnk UREIDOGLYCINE-GLYOXY
LATE
AMINOTRANSFERASE

(Klebsiella
pneumoniae) 		PF00266
(Aminotran_5) 		5 THR A  61
PHE A  59
ALA A 196
LEU A 251
ALA A  84
 None
 1.04A 6efnA-3nnkA:
2.0		 6efnA-3nnkA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3odg XANTHOSINE
PHOSPHORYLASE

(Yersinia
pseudotuberculosis) 		PF01048
(PNP_UDP_1) 		5 PHE A 196
SER A 224
ARG A  93
THR A 262
ALA A 266
 None
CL  A 289 ( 4.8A)
CL  A 289 ( 4.8A)
XAN  A 288 (-3.5A)
None
 1.44A 6efnA-3odgA:
undetectable		 6efnA-3odgA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p5m ENOYL-COA
HYDRATASE/ISOMERASE

(Mycobacterium
avium) 		PF00378
(ECH_1) 		5 PHE A 121
SER A 119
ALA A 115
THR A  53
LEU A  52
 None
 1.44A 6efnA-3p5mA:
2.3		 6efnA-3p5mA:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qp9 TYPE I POLYKETIDE
SYNTHASE PIKAII

(Streptomyces
venezuelae) 		PF08659
(KR) 		5 THR A 236
GLU A 239
ALA A 351
THR A 398
ALA A 419
 None
 1.47A 6efnA-3qp9A:
2.2		 6efnA-3qp9A:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qxi ENOYL-COA HYDRATASE
ECHA1

(Mycobacterium
marinum) 		PF00378
(ECH_1) 		5 PHE A 130
SER A 128
ALA A 124
THR A  61
LEU A  60
 None
 1.41A 6efnA-3qxiA:
undetectable		 6efnA-3qxiA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s2u UDP-N-ACETYLGLUCOSAM
INE--N-ACETYLMURAMYL
-(PENTAPEPTIDE)
PYROPHOSPHORYL-UNDEC
APRENOL
N-ACETYLGLUCOSAMINE
TRANSFERASE

(Pseudomonas
aeruginosa) 		PF03033
(Glyco_transf_28)
PF04101
(Glyco_tran_28_C) 		5 THR A 148
PHE A 149
ALA A 135
THR A 104
ALA A   9
 None
 1.36A 6efnA-3s2uA:
undetectable		 6efnA-3s2uA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sun DNA POLYMERASE

(Escherichia
virus RB69) 		PF00136
(DNA_pol_B)
PF03104
(DNA_pol_B_exo1) 		5 THR A 644
GLU A 638
SER A 695
LEU A 725
ALA A 709
 None
 1.47A 6efnA-3sunA:
undetectable		 6efnA-3sunA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ubo ADENOSINE KINASE

(Sinorhizobium
meliloti) 		PF00294
(PfkB) 		5 ARG A 315
ALA A  12
THR A   8
LEU A   7
ALA A  75
 None
 1.24A 6efnA-3uboA:
2.6		 6efnA-3uboA:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3un6 HYPOTHETICAL PROTEIN
SAOUHSC_00137

(Staphylococcus
aureus) 		PF13379
(NMT1_2) 		5 PHE A 312
ALA A  97
THR A 148
LEU A 151
ALA A 218
 None
 1.22A 6efnA-3un6A:
undetectable		 6efnA-3un6A:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v98 ARACHIDONATE
5-LIPOXYGENASE

(Homo sapiens) 		PF00305
(Lipoxygenase)
PF01477
(PLAT) 		5 TYR A  94
ALA A  11
THR A   9
THR A   7
LEU A  87
 None
 1.38A 6efnA-3v98A:
undetectable		 6efnA-3v98A:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3voc BETA/ALPHA-AMYLASE

(Paenibacillus
polymyxa) 		PF01373
(Glyco_hydro_14) 		5 GLU A 120
SER A 168
ALA A 299
THR A 296
LEU A 341
 None
 1.46A 6efnA-3vocA:
7.4		 6efnA-3vocA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vr0 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Pyrococcus
furiosus) 		PF09754
(PAC2) 		5 PHE A 126
ALA A  60
THR A 103
LEU A  36
ALA A  47
 None
 1.48A 6efnA-3vr0A:
undetectable		 6efnA-3vr0A:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vs8 TYPE III POLYKETIDE
SYNTHASE

(Azotobacter
vinelandii) 		PF02797
(Chal_sti_synt_C) 		5 THR A 143
GLU A 141
PHE A 140
ALA A 217
LEU A  12
 None
 1.29A 6efnA-3vs8A:
undetectable		 6efnA-3vs8A:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vsk PENICILLIN-BINDING
PROTEIN 3

(Staphylococcus
aureus) 		PF00905
(Transpeptidase)
PF03717
(PBP_dimer) 		5 THR A 247
SER A 225
ALA A  88
THR A  90
THR A  92
 None
 1.27A 6efnA-3vskA:
0.0		 6efnA-3vskA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vwx GLUTATHIONE
S-TRANSFERASE 6B

(Musca domestica) 		PF00043
(GST_C)
PF13417
(GST_N_3) 		5 THR A 169
ALA A  17
THR A 158
LEU A 157
ALA A 153
 None
 1.44A 6efnA-3vwxA:
undetectable		 6efnA-3vwxA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w5n PUTATIVE
RHAMNOSIDASE

(Streptomyces
avermitilis) 		PF05592
(Bac_rhamnosid)
PF08531
(Bac_rhamnosid_N)
PF17389
(Bac_rhamnosid6H)
PF17390
(Bac_rhamnosid_C) 		5 TYR A 940
PHE A 600
ALA A 958
THR A 969
ALA A 990
 None
 1.43A 6efnA-3w5nA:
undetectable		 6efnA-3w5nA:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a0h ADENOSYLMETHIONINE-8
-AMINO-7-OXONONANOAT
E AMINOTRANSFERASE

(Arabidopsis
thaliana) 		PF00202
(Aminotran_3)
PF13500
(AAA_26) 		5 THR A 477
SER A 428
ALA A 654
THR A 656
ALA A 442
 None
 1.08A 6efnA-4a0hA:
2.6		 6efnA-4a0hA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4acj WU:FB25H12 PROTEIN,

(Danio rerio) 		PF07534
(TLD) 		5 TYR A 717
PHE A 710
ALA A 704
THR A 722
THR A 719
 None
 1.43A 6efnA-4acjA:
undetectable		 6efnA-4acjA:
17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bi9 3-KETOACYL-COA
THIOLASE, PUTATIVE

(Trypanosoma
brucei) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		5 THR A 390
GLU A 333
ALA A 341
THR A 310
ALA A 294
 None
 1.45A 6efnA-4bi9A:
undetectable		 6efnA-4bi9A:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cns DIHYDROPYRIMIDINASE-
LIKE 3

(Homo sapiens) 		PF01979
(Amidohydro_1) 		5 GLU A 360
SER A 427
ALA A 428
THR A 338
ALA A 296
 None
 1.40A 6efnA-4cnsA:
5.2		 6efnA-4cnsA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cnt DIHYDROPYRIMIDINASE-
LIKE 3

(Homo sapiens) 		PF01979
(Amidohydro_1) 		5 GLU A 360
SER A 427
ALA A 428
THR A 338
ALA A 296
 None
 1.37A 6efnA-4cntA:
5.4		 6efnA-4cntA:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dwe UNCHARACTERIZED
PROTEIN

(Bacteroides
ovatus) 		PF15421
(Polysacc_deac_3) 		5 TYR A 266
THR A 246
GLU A 368
ALA A 167
ALA A 262
 None
 1.08A 6efnA-4dweA:
undetectable		 6efnA-4dweA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e3a SUGAR KINASE PROTEIN

(Rhizobium etli) 		PF00294
(PfkB) 		5 ARG A 313
ALA A  10
THR A   6
LEU A   5
ALA A  73
 None
 1.22A 6efnA-4e3aA:
2.9		 6efnA-4e3aA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f7g TALIN-1

(Mus musculus) 		no annotation 5 GLU B1770
SER B1679
ALA B1678
THR B1752
ALA B1817
 None
 1.27A 6efnA-4f7gB:
undetectable		 6efnA-4f7gB:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4glf RSFP

(uncultured
bacterium) 		PF01048
(PNP_UDP_1) 		5 SER A  97
ARG A  64
ALA A 218
THR A 216
ALA A 207
 None
 1.41A 6efnA-4glfA:
undetectable		 6efnA-4glfA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mx2 ADENYLOSUCCINATE
LYASE

(Leishmania
donovani) 		PF00206
(Lyase_1)
PF08328
(ASL_C) 		5 SER A 385
ARG A 388
ALA A 382
THR A  45
LEU A  37
 None
 1.31A 6efnA-4mx2A:
undetectable		 6efnA-4mx2A:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nf8 GLUTAMATE RECEPTOR
IONOTROPIC, NMDA 1

(Rattus
norvegicus) 		PF10613
(Lig_chan-Glu_bd) 		5 PHE A 171
THR A 241
THR A 240
LEU A 228
ALA A 232
 None
 1.35A 6efnA-4nf8A:
undetectable		 6efnA-4nf8A:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q65 DIPEPTIDE PERMEASE D

(Escherichia
coli) 		PF00854
(PTR2) 		5 GLU A  49
SER A  56
ALA A 424
LEU A  64
ALA A 222
 None
 1.33A 6efnA-4q65A:
undetectable		 6efnA-4q65A:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qcc 2-DEHYDRO-3-DEOXY-6-
PHOSPHOGALACTONATE
ALDOLASE,
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
CHIMERA

(Escherichia
coli) 		PF01081
(Aldolase)
PF01346
(FKBP_N) 		5 THR A  86
SER A  91
ALA A 120
THR A 116
THR A 112
 None
 1.43A 6efnA-4qccA:
7.3		 6efnA-4qccA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qwp CHITOSANASE

(Pseudomonas sp.
A-01) 		PF01374
(Glyco_hydro_46) 		5 PHE A  24
ARG A 193
ALA A 212
LEU A   8
ALA A 129
 None
 1.34A 6efnA-4qwpA:
undetectable		 6efnA-4qwpA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rit PYRIDOXAL-DEPENDENT
DECARBOXYLASE

(Sphaerobacter
thermophilus) 		no annotation 5 SER B 186
ALA B 189
THR B 246
THR B 249
ALA B 398
 None
 1.25A 6efnA-4ritB:
undetectable		 6efnA-4ritB:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4txg CHITINASE

(Chromobacterium
violaceum) 		PF00704
(Glyco_hydro_18)
PF06483
(ChiC) 		5 THR A 635
PHE A 636
THR A 441
LEU A 413
ALA A 411
 None
 1.43A 6efnA-4txgA:
3.6		 6efnA-4txgA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w1w ADENOSYLMETHIONINE-8
-AMINO-7-OXONONANOAT
E AMINOTRANSFERASE

(Mycobacterium
tuberculosis) 		PF00202
(Aminotran_3) 		5 THR A 161
SER A 121
ALA A 293
THR A 295
ALA A 135
 None
 1.10A 6efnA-4w1wA:
undetectable		 6efnA-4w1wA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xea PEPTIDASE M16 DOMAIN
PROTEIN

(Alicyclobacillus
acidocaldarius) 		PF00675
(Peptidase_M16)
PF05193
(Peptidase_M16_C) 		5 GLU A 135
PHE A  74
ALA A  94
THR A 101
THR A  43
 None
 1.29A 6efnA-4xeaA:
undetectable		 6efnA-4xeaA:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z8s RRNA N-GLYCOSIDASE

(Momordica
charantia) 		PF00161
(RIP) 		5 PHE A 166
SER A 220
ALA A 186
THR A 182
LEU A 127
 None
 1.19A 6efnA-4z8sA:
undetectable		 6efnA-4z8sA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5axi E3 UBIQUITIN-PROTEIN
LIGASE CBL-B

(Mus musculus) 		PF02262
(Cbl_N)
PF02761
(Cbl_N2)
PF02762
(Cbl_N3) 		5 TYR A 110
PHE A 150
SER A 118
THR A  49
ALA A  41
 None
 1.37A 6efnA-5axiA:
undetectable		 6efnA-5axiA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bp1 MYCOCEROSIC ACID
SYNTHASE

(Mycolicibacterium
smegmatis) 		PF00109
(ketoacyl-synt)
PF00698
(Acyl_transf_1)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		5 PHE A 582
SER A 580
ARG A 656
THR A 655
ALA A 662
 None
 1.38A 6efnA-5bp1A:
undetectable		 6efnA-5bp1A:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c2z EXFOLIATIVE TOXIN D2

(Staphylococcus
aureus) 		PF00089
(Trypsin) 		5 PHE A 224
SER A  69
ALA A 167
THR A  93
ALA A  81
 None
 1.31A 6efnA-5c2zA:
undetectable		 6efnA-5c2zA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d6d LOW AFFINITY
IMMUNOGLOBULIN GAMMA
FC REGION RECEPTOR
III-A

(Homo sapiens) 		PF13895
(Ig_2) 		5 THR C  26
SER C  51
ALA C  53
THR C  40
THR C  73
 None
 1.40A 6efnA-5d6dC:
undetectable		 6efnA-5d6dC:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ez3 ACYL-COA
DEHYDROGENASE

(Brucella
melitensis) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M) 		5 THR A 387
ARG A 126
ALA A 149
THR A 145
ALA A 134
 None
None
None
MRD  A 601 (-3.7A)
None
 1.41A 6efnA-5ez3A:
undetectable		 6efnA-5ez3A:
23.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hql RIBULOSE
BISPHOSPHATE
CARBOXYLASE

(Rhodopseudomonas
palustris) 		PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N) 		5 THR A 392
PHE A 190
SER A 230
ALA A 260
ALA A 313
 KCX  A 192 ( 3.1A)
KCX  A 192 ( 4.0A)
KCX  A 192 ( 3.9A)
None
None
 1.42A 6efnA-5hqlA:
6.0		 6efnA-5hqlA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i32 AQUAPORIN TIP2-1

(Arabidopsis
thaliana) 		PF00230
(MIP) 		5 SER A 192
ALA A 188
THR A 150
LEU A 153
ALA A  85
 None
 1.32A 6efnA-5i32A:
0.0		 6efnA-5i32A:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ikz OXALATE BIOSYNTHETIC
COMPONENT 1

(Burkholderia
thailandensis) 		PF05853
(BKACE) 		5 TYR A 201
THR A 142
THR A 497
LEU A 476
ALA A 212
 None
 1.42A 6efnA-5ikzA:
5.8		 6efnA-5ikzA:
16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jp3 XANTHOMONAS OUTER
PROTEIN D

(Xanthomonas
euvesicatoria) 		PF02902
(Peptidase_C48) 		5 THR A 456
GLU A 458
SER A 411
THR A 373
LEU A 375
 None
 1.47A 6efnA-5jp3A:
undetectable		 6efnA-5jp3A:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k3h ACYL-COENZYME A
OXIDASE

(Caenorhabditis
elegans) 		PF01756
(ACOX)
PF02770
(Acyl-CoA_dh_M)
PF14749
(Acyl-CoA_ox_N) 		5 THR A  24
PHE A  25
SER A 617
THR A 314
ALA A 318
 None
 1.36A 6efnA-5k3hA:
undetectable		 6efnA-5k3hA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5khn RND TRANSPORTER

(Burkholderia
multivorans) 		no annotation 5 THR B  72
GLU B 262
ALA B 505
THR B 537
ALA B 668
 None
 1.30A 6efnA-5khnB:
undetectable		 6efnA-5khnB:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lkd GLUTATHIONE
S-TRANSFERASE
OMEGA-LIKE 2

(Saccharomyces
cerevisiae) 		PF13409
(GST_N_2)
PF13410
(GST_C_2) 		5 THR A 359
PHE A 116
ARG A 125
THR A 107
LEU A  44
 None
 1.37A 6efnA-5lkdA:
undetectable		 6efnA-5lkdA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lkd GLUTATHIONE
S-TRANSFERASE
OMEGA-LIKE 2

(Saccharomyces
cerevisiae) 		PF13409
(GST_N_2)
PF13410
(GST_C_2) 		5 THR A 359
PHE A 116
THR A 107
LEU A  44
ALA A 130
 None
 1.36A 6efnA-5lkdA:
undetectable		 6efnA-5lkdA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m10 CYCLOHEXANONE
MONOOXYGENASE FROM
THERMOCRISPUM
MUNICIPALE

(Thermocrispum
municipale) 		PF07992
(Pyr_redox_2) 		5 TYR A 326
PHE A 269
ALA A 257
THR A 291
LEU A 485
 None
 1.28A 6efnA-5m10A:
undetectable		 6efnA-5m10A:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mac RIBULOSE-1,5-BISPHOS
PHATE
CARBOXYLASE-OXYGENAS
E TYPE III

(Methanococcoides
burtonii) 		PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N) 		5 THR A 422
PHE A 191
SER A 231
ALA A 260
ALA A 313
 KCX  A 193 ( 3.7A)
KCX  A 193 ( 4.8A)
KCX  A 193 ( 4.6A)
None
None
 1.40A 6efnA-5macA:
5.5		 6efnA-5macA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ol2 ELECTRON TRANSFER
FLAVOPROTEIN LARGE
SUBUNIT
ELECTRON TRANSFER
FLAVOPROTEIN SMALL
SUBUNIT

(Clostridioides
difficile;
Clostridioides
difficile) 		no annotation
no annotation 		5 THR A 158
PHE A  95
ALA A  81
THR A  78
ALA B 137
 None
 1.18A 6efnA-5ol2A:
undetectable		 6efnA-5ol2A:
23.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5txr 5-AMINOLEVULINATE
SYNTHASE,
MITOCHONDRIAL

(Saccharomyces
cerevisiae) 		no annotation 5 SER B 349
ALA B 348
THR B 278
LEU B 248
ALA B 271
 None
 1.35A 6efnA-5txrB:
1.9		 6efnA-5txrB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5txr 5-AMINOLEVULINATE
SYNTHASE,
MITOCHONDRIAL

(Saccharomyces
cerevisiae) 		no annotation 5 SER B 349
ALA B 348
THR B 278
LEU B 248
ALA B 276
 None
 1.13A 6efnA-5txrB:
1.9		 6efnA-5txrB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vsl RADICAL S-ADENOSYL
METHIONINE
DOMAIN-CONTAINING
PROTEIN 2

(Mus musculus) 		PF04055
(Radical_SAM)
PF13353
(Fer4_12) 		5 GLU A 127
SER A 180
ARG A 194
LEU A 252
ALA A 267
 SAH  A 402 (-4.3A)
SAH  A 402 (-2.4A)
SAH  A 402 ( 3.4A)
SAH  A 402 (-4.5A)
None
 0.91A 6efnA-5vslA:
5.6		 6efnA-5vslA:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wwo ESSENTIAL NUCLEAR
PROTEIN 1

(Saccharomyces
cerevisiae) 		PF05291
(Bystin) 		5 GLU A 285
PHE A 321
ALA A 338
THR A 368
LEU A 359
 None
 1.47A 6efnA-5wwoA:
undetectable		 6efnA-5wwoA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xip PROLYL-TRNA
SYNTHETASE, PUTATIVE

(Eimeria tenella) 		no annotation 5 THR A 412
THR A 460
THR A 462
LEU A 428
ALA A 477
 None
 1.42A 6efnA-5xipA:
undetectable		 6efnA-5xipA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yim SDEA

(Legionella
pneumophila) 		no annotation 5 THR A 821
ALA A 751
THR A 748
THR A 745
ALA A 726
 None
 1.37A 6efnA-5yimA:
undetectable		 6efnA-5yimA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bvg PROTEIN-N(PI)-PHOSPH
OHISTIDINE-SUGAR
PHOSPHOTRANSFERASE
(ENZYME II OF THE
PHOSPHOTRANSFERASE
SYSTEM) (PTS SYSTEM
GLUCOSE-SPECIFIC
IIBC COMPONENT)

(Bacillus cereus) 		no annotation 5 THR A 229
GLU A 231
ALA A 317
LEU A 435
ALA A 365
 None
MAL  A 501 (-3.6A)
None
None
None
 1.18A 6efnA-6bvgA:
undetectable		 6efnA-6bvgA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6chs PUTATIVE CELL
DIVISION CONTROL
PROTEIN

(Chaetomium
thermophilum) 		no annotation 5 GLU H 769
ALA H 702
THR H 542
LEU H 544
ALA H 639
 None
AGS  H 902 (-3.5A)
MG  H 904 ( 3.3A)
None
None
 1.16A 6efnA-6chsH:
undetectable		 6efnA-6chsH:
undetectable