SIMILAR PATTERNS OF AMINO ACIDS FOR 6EF6_A_BEZA401

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c9w CHO REDUCTASE

(Cricetulus
griseus) 		PF00248
(Aldo_ket_red) 		5 LEU A 170
ARG A 168
PHE A 137
VAL A 158
ILE A 166
 None
 1.20A 6ef6A-1c9wA:
0.0		 6ef6A-1c9wA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cs6 AXONIN-1

(Gallus gallus) 		PF07679
(I-set)
PF13927
(Ig_3) 		5 LEU A  33
THR A  20
PRO A  74
PHE A  22
ILE A  71
 None
 1.28A 6ef6A-1cs6A:
undetectable		 6ef6A-1cs6A:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dxx DYSTROPHIN

(Homo sapiens) 		PF00307
(CH) 		5 LEU A 131
THR A 134
ILE A 139
VAL A 243
ILE A 245
 None
 1.30A 6ef6A-1dxxA:
undetectable		 6ef6A-1dxxA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ggp PROTEIN (LECTIN 1 A
CHAIN)

(Trichosanthes
kirilowii) 		PF00161
(RIP) 		5 LEU A 141
SER A 140
THR A 154
ILE A 158
ILE A 138
 None
 1.05A 6ef6A-1ggpA:
0.3		 6ef6A-1ggpA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1guz MALATE DEHYDROGENASE

(Chlorobaculum
tepidum;
Prosthecochloris
vibrioformis) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		5 LEU A  31
THR A  67
ILE A 105
VAL A 101
ILE A   6
 None
 1.23A 6ef6A-1guzA:
0.0		 6ef6A-1guzA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gv0 MALATE DEHYDROGENASE

(Chlorobaculum
tepidum) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		5 LEU A  31
THR A  67
ILE A 105
VAL A 101
ILE A   6
 None
 1.10A 6ef6A-1gv0A:
0.0		 6ef6A-1gv0A:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hqs ISOCITRATE
DEHYDROGENASE

(Bacillus
subtilis) 		PF00180
(Iso_dh) 		5 LEU A 109
ILE A  25
PRO A  23
VAL A  61
ILE A  83
 None
 1.07A 6ef6A-1hqsA:
undetectable		 6ef6A-1hqsA:
24.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ml4 ASPARTATE
TRANSCARBAMOYLASE

(Pyrococcus
abyssi) 		PF00185
(OTCace)
PF02729
(OTCace_N) 		5 LEU A 143
THR A 139
ILE A  11
PHE A  14
ILE A  19
 None
 1.30A 6ef6A-1ml4A:
undetectable		 6ef6A-1ml4A:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mqq ALPHA-D-GLUCURONIDAS
E

(Geobacillus
stearothermophilus) 		PF03648
(Glyco_hydro_67N)
PF07477
(Glyco_hydro_67C)
PF07488
(Glyco_hydro_67M) 		5 LEU A 134
SER A 135
ILE A 104
ARG A  94
ILE A  93
 None
None
None
GOL  A 762 ( 3.1A)
None
 1.29A 6ef6A-1mqqA:
1.3		 6ef6A-1mqqA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1np3 KETOL-ACID
REDUCTOISOMERASE

(Pseudomonas
aeruginosa) 		PF01450
(IlvC)
PF07991
(IlvN) 		5 LEU A  88
THR A  80
ILE A  22
VAL A  70
ILE A  93
 None
 1.26A 6ef6A-1np3A:
0.0		 6ef6A-1np3A:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ps9 2,4-DIENOYL-COA
REDUCTASE

(Escherichia
coli) 		PF00724
(Oxidored_FMN)
PF07992
(Pyr_redox_2) 		5 SER A 595
ILE A 500
ARG A 562
PRO A 470
ILE A 472
 None
None
NAP  A 703 (-3.5A)
NAP  A 703 ( 4.3A)
None
 1.28A 6ef6A-1ps9A:
undetectable		 6ef6A-1ps9A:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qcq PROTEIN (UBIQUITIN
CONJUGATING ENZYME)

(Saccharomyces
cerevisiae) 		PF00179
(UQ_con) 		5 LEU A  53
SER A  54
PRO A  66
VAL A 103
ILE A  68
 None
 1.25A 6ef6A-1qcqA:
undetectable		 6ef6A-1qcqA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qfj PROTEIN (FLAVIN
REDUCTASE)

(Escherichia
coli) 		PF00175
(NAD_binding_1)
PF00970
(FAD_binding_6) 		5 LEU A  62
PRO A  24
PHE A  28
VAL A  88
ILE A  22
 None
 1.03A 6ef6A-1qfjA:
undetectable		 6ef6A-1qfjA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rcy RUSTICYANIN

(Acidithiobacillus
ferrooxidans) 		PF00127
(Copper-bind) 		5 LEU A  46
THR A  79
ILE A  77
PHE A  76
VAL A  41
 None
 1.29A 6ef6A-1rcyA:
undetectable		 6ef6A-1rcyA:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vzo RIBOSOMAL PROTEIN S6
KINASE ALPHA 5

(Homo sapiens) 		PF00069
(Pkinase) 		5 LEU A 244
SER A 240
ILE A 183
VAL A 191
ILE A 161
 None
 1.17A 6ef6A-1vzoA:
4.5		 6ef6A-1vzoA:
23.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a4d UBIQUITIN-CONJUGATIN
G ENZYME E2 VARIANT
1

(Homo sapiens) 		PF00179
(UQ_con) 		5 LEU A 141
SER A 140
THR A 160
ILE A 162
ILE A 126
 None
 1.27A 6ef6A-2a4dA:
undetectable		 6ef6A-2a4dA:
24.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d5m FLAVOREDOXIN

(Desulfovibrio
vulgaris) 		PF01613
(Flavin_Reduct) 		5 LEU A  96
SER A  95
ILE A  30
PRO A 100
VAL A 111
 None
 1.28A 6ef6A-2d5mA:
undetectable		 6ef6A-2d5mA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dfu PROBABLE
2-HYDROXYHEPTA-2,4-D
IENE-1,7-DIOATE
ISOMERASE

(Thermus
thermophilus) 		PF01557
(FAA_hydrolase)
PF10370
(DUF2437) 		5 LEU A 111
ILE A 256
PRO A 169
VAL A 102
ILE A 146
 None
 1.21A 6ef6A-2dfuA:
undetectable		 6ef6A-2dfuA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2egw UPF0088 PROTEIN
AQ_165

(Aquifex
aeolicus) 		PF04452
(Methyltrans_RNA) 		5 LEU A 151
SER A 149
ARG A 147
VAL A 102
ILE A 104
 None
 1.21A 6ef6A-2egwA:
undetectable		 6ef6A-2egwA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i5g AMIDOHYDROLASE

(Pseudomonas
aeruginosa) 		PF01244
(Peptidase_M19) 		5 LEU A 294
THR A 297
ARG A 301
VAL A 311
ILE A 233
 None
 1.28A 6ef6A-2i5gA:
undetectable		 6ef6A-2i5gA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2im9 HYPOTHETICAL PROTEIN

(Legionella
pneumophila) 		PF07313
(DUF1460) 		5 LEU A 126
SER A 127
THR A 144
PRO A 342
PHE A 352
 None
 1.26A 6ef6A-2im9A:
undetectable		 6ef6A-2im9A:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j4h DEOXYCYTIDINE
TRIPHOSPHATE
DEAMINASE

(Escherichia
coli) 		PF00692
(dUTPase) 		5 LEU A  17
ILE A   8
PRO A  23
VAL A  33
ILE A  19
 None
 1.22A 6ef6A-2j4hA:
undetectable		 6ef6A-2j4hA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p1g PUTATIVE XYLANASE

(Bacteroides
fragilis) 		PF07313
(DUF1460) 		5 LEU A 238
SER A 239
ILE A 189
VAL A 253
ILE A 251
 None
 1.14A 6ef6A-2p1gA:
undetectable		 6ef6A-2p1gA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qtz METHIONINE SYNTHASE
REDUCTASE

(Homo sapiens) 		PF00175
(NAD_binding_1)
PF00667
(FAD_binding_1) 		5 LEU A 466
ILE A 522
PHE A 274
VAL A 276
ILE A 300
 None
 1.24A 6ef6A-2qtzA:
undetectable		 6ef6A-2qtzA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v95 CORTICOSTEROID-BINDI
NG GLOBULIN

(Rattus
norvegicus) 		PF00079
(Serpin) 		5 SER A 368
ILE A 247
PRO A 238
VAL A 246
ILE A 353
 None
 1.28A 6ef6A-2v95A:
undetectable		 6ef6A-2v95A:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vak SIGMA A

(Avian
orthoreovirus) 		PF03084
(Sigma_1_2) 		5 SER A 226
THR A 174
ILE A 272
VAL A 270
ILE A 242
 None
 1.28A 6ef6A-2vakA:
undetectable		 6ef6A-2vakA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vdc GLUTAMATE SYNTHASE
[NADPH] LARGE CHAIN

(Azospirillum
brasilense) 		PF00310
(GATase_2)
PF01493
(GXGXG)
PF01645
(Glu_synthase)
PF04898
(Glu_syn_central) 		5 LEU A 362
THR A 358
ILE A 374
VAL A 372
ILE A 364
 None
 1.20A 6ef6A-2vdcA:
undetectable		 6ef6A-2vdcA:
13.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x40 BETA-GLUCOSIDASE

(Thermotoga
neapolitana) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		5 LEU A 471
SER A 472
ILE A 479
VAL A 495
ILE A 452
 None
 0.99A 6ef6A-2x40A:
undetectable		 6ef6A-2x40A:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xdh COHESIN

(Archaeoglobus
fulgidus) 		PF00963
(Cohesin) 		5 LEU A  87
SER A  86
THR A  57
VAL A  33
ILE A  27
 None
 1.26A 6ef6A-2xdhA:
undetectable		 6ef6A-2xdhA:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yn0 TRANSCRIPTION FACTOR
TAU 55 KDA SUBUNIT

(Saccharomyces
cerevisiae) 		PF00300
(His_Phos_1) 		5 LEU A 180
ILE A 151
PHE A 150
VAL A   3
ILE A   6
 None
 1.27A 6ef6A-2yn0A:
undetectable		 6ef6A-2yn0A:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yyz SUGAR ABC
TRANSPORTER,
ATP-BINDING PROTEIN

(Thermotoga
maritima) 		PF00005
(ABC_tran)
PF08402
(TOBE_2) 		5 LEU A  35
ILE A 234
PRO A 218
VAL A 221
ILE A 204
 None
 1.28A 6ef6A-2yyzA:
undetectable		 6ef6A-2yyzA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z87 CHONDROITIN SYNTHASE

(Escherichia
coli) 		PF00535
(Glycos_transf_2) 		5 LEU A 479
THR A 475
ILE A 447
VAL A 451
ILE A 466
 None
 1.25A 6ef6A-2z87A:
undetectable		 6ef6A-2z87A:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aje PUTATIVE
UNCHARACTERIZED
PROTEIN ST1526

(Sulfurisphaera
tokodaii) 		PF01300
(Sua5_yciO_yrdC)
PF03481
(SUA5) 		5 THR A 105
ARG A 107
PRO A 139
PHE A  45
VAL A  67
 None
 1.09A 6ef6A-3ajeA:
undetectable		 6ef6A-3ajeA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b4r PUTATIVE ZINC
METALLOPROTEASE
MJ0392

(Methanocaldococcus
jannaschii) 		PF02163
(Peptidase_M50) 		5 LEU A 157
SER A 158
ARG A 154
PHE A 145
ILE A 169
 None
 1.14A 6ef6A-3b4rA:
undetectable		 6ef6A-3b4rA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bf0 PROTEASE 4

(Escherichia
coli) 		PF01343
(Peptidase_S49) 		5 LEU A 389
ILE A 368
ARG A 360
VAL A 331
ILE A 356
 None
 1.16A 6ef6A-3bf0A:
undetectable		 6ef6A-3bf0A:
24.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eno PUTATIVE
O-SIALOGLYCOPROTEIN
ENDOPEPTIDASE

(Thermoplasma
acidophilum) 		PF00814
(Peptidase_M22) 		5 LEU A   6
SER A  75
THR A  87
ILE A  51
VAL A  54
 None
 1.24A 6ef6A-3enoA:
undetectable		 6ef6A-3enoA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g1z PUTATIVE LYSYL-TRNA
SYNTHETASE

(Salmonella
enterica) 		PF00152
(tRNA-synt_2) 		5 LEU A 147
SER A 146
ILE A 204
VAL A 200
ILE A 212
 None
 1.26A 6ef6A-3g1zA:
1.2		 6ef6A-3g1zA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ir8 LARGE STOKES SHIFT
FLUORESCENT PROTEIN

(Montipora sp.
20) 		PF01353
(GFP) 		5 LEU A  57
SER A  58
ILE A 120
VAL A  18
ILE A  56
 None
 1.30A 6ef6A-3ir8A:
undetectable		 6ef6A-3ir8A:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kzx HAD-SUPERFAMILY
HYDROLASE, SUBFAMILY
IA, VARIANT 1

(Ehrlichia
chaffeensis) 		PF13419
(HAD_2) 		5 LEU A  15
THR A  14
ILE A 162
PHE A 161
VAL A   7
 None
 1.27A 6ef6A-3kzxA:
undetectable		 6ef6A-3kzxA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lmm UNCHARACTERIZED
PROTEIN

(Corynebacterium
diphtheriae) 		PF04326
(AlbA_2)
PF13749
(HATPase_c_4) 		5 LEU A 105
ILE A 132
ARG A 106
VAL A  72
ILE A 109
 None
 0.94A 6ef6A-3lmmA:
undetectable		 6ef6A-3lmmA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mfq HIGH-AFFINITY ZINC
UPTAKE SYSTEM
PROTEIN ZNUA

(Streptococcus
suis) 		PF01297
(ZnuA) 		5 LEU A 257
THR A 231
ILE A 235
VAL A 268
ILE A 243
 None
 1.22A 6ef6A-3mfqA:
undetectable		 6ef6A-3mfqA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mg6 PROTEASOME COMPONENT
C11

(Saccharomyces
cerevisiae) 		PF00227
(Proteasome) 		5 LEU J  37
SER J  38
THR J  41
ILE J 101
VAL J  83
 None
 1.24A 6ef6A-3mg6J:
undetectable		 6ef6A-3mg6J:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mvk PROTEIN FUCU

(Bifidobacterium
longum) 		PF05025
(RbsD_FucU) 		5 LEU A  13
ILE A  59
PRO A   6
VAL A  62
ILE A   9
 None
 1.28A 6ef6A-3mvkA:
undetectable		 6ef6A-3mvkA:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n9i TRYPTOPHANYL-TRNA
SYNTHETASE

(Yersinia pestis) 		PF00579
(tRNA-synt_1b) 		5 LEU A 201
SER A 200
ILE A 261
VAL A 293
ILE A 219
 None
 1.07A 6ef6A-3n9iA:
undetectable		 6ef6A-3n9iA:
24.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nks PROTOPORPHYRINOGEN
OXIDASE

(Homo sapiens) 		PF01593
(Amino_oxidase) 		5 LEU A 236
ILE A  61
PRO A  58
VAL A 456
ILE A  43
 None
None
FAD  A 479 (-3.9A)
FAD  A 479 (-4.0A)
None
 1.08A 6ef6A-3nksA:
undetectable		 6ef6A-3nksA:
23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nnk UREIDOGLYCINE-GLYOXY
LATE
AMINOTRANSFERASE

(Klebsiella
pneumoniae) 		PF00266
(Aminotran_5) 		5 LEU A 383
THR A 379
ILE A 364
VAL A 327
ILE A 306
 None
 1.28A 6ef6A-3nnkA:
undetectable		 6ef6A-3nnkA:
23.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o3r ALDO-KETO REDUCTASE
FAMILY 1, MEMBER B7

(Rattus
norvegicus) 		PF00248
(Aldo_ket_red) 		5 LEU A 171
ARG A 169
PHE A 138
VAL A 159
ILE A 167
 None
 1.30A 6ef6A-3o3rA:
undetectable		 6ef6A-3o3rA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pds FUSION PROTEIN
BETA-2 ADRENERGIC
RECEPTOR/LYSOZYME

(Homo sapiens;
Escherichia
virus T4) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		5 LEU A  75
SER A  74
THR A 123
ILE A 127
ILE A  72
 None
CLR  A1202 ( 4.9A)
None
None
None
 0.96A 6ef6A-3pdsA:
1.9		 6ef6A-3pdsA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3swg UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE

(Aquifex
aeolicus) 		PF00275
(EPSP_synthase) 		5 LEU A 178
THR A 174
ILE A 193
VAL A 215
ILE A 203
 None
 1.10A 6ef6A-3swgA:
undetectable		 6ef6A-3swgA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t5v NUCLEAR MRNA EXPORT
PROTEIN THP1

(Saccharomyces
cerevisiae) 		PF01399
(PCI) 		5 LEU B 152
SER B 150
ILE B  99
ARG B 151
ILE B  95
 None
 1.21A 6ef6A-3t5vB:
undetectable		 6ef6A-3t5vB:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tqc PANTOTHENATE KINASE

(Coxiella
burnetii) 		PF00485
(PRK) 		5 LEU A 161
ILE A  91
PRO A  89
VAL A 197
ILE A 164
 None
 1.26A 6ef6A-3tqcA:
undetectable		 6ef6A-3tqcA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vb9 UNCHARACTERIZED
PROTEIN VPA0735

(Vibrio
parahaemolyticus) 		PF06742
(DUF1214)
PF06863
(DUF1254) 		5 LEU A 122
THR A 119
PRO A 181
VAL A 186
ILE A 161
 None
 1.24A 6ef6A-3vb9A:
undetectable		 6ef6A-3vb9A:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w36 NAPH1

(Streptomyces
sp. CNQ525) 		no annotation 5 LEU A 317
SER A 487
ILE A 474
PHE A 480
ILE A 320
 None
 1.25A 6ef6A-3w36A:
undetectable		 6ef6A-3w36A:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w36 NAPH1

(Streptomyces
sp. CNQ525) 		no annotation 5 LEU A 317
SER A 487
THR A 483
ILE A 474
ILE A 320
 None
 1.08A 6ef6A-3w36A:
undetectable		 6ef6A-3w36A:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wiq KOJIBIOSE
PHOSPHORYLASE

(Caldicellulosiruptor
saccharolyticus) 		PF03632
(Glyco_hydro_65m)
PF03633
(Glyco_hydro_65C)
PF03636
(Glyco_hydro_65N) 		5 LEU A 714
SER A 713
ILE A 295
VAL A 307
ILE A 297
 None
 1.24A 6ef6A-3wiqA:
1.4		 6ef6A-3wiqA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aur LEOA

(Escherichia
coli) 		PF00350
(Dynamin_N) 		5 LEU A 400
SER A 401
THR A 397
ILE A 444
VAL A 538
 None
 1.26A 6ef6A-4aurA:
undetectable		 6ef6A-4aurA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b6l SERINE/THREONINE-PRO
TEIN KINASE PLK3

(Homo sapiens) 		PF00069
(Pkinase) 		5 LEU A 295
ARG A 296
PRO A 303
VAL A 243
ILE A 294
 None
 1.16A 6ef6A-4b6lA:
7.7		 6ef6A-4b6lA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bxw FACTOR XA

(Pseudonaja
textilis) 		PF00089
(Trypsin)
PF14670
(FXa_inhibition) 		5 LEU A 187
THR A 208
ILE A 269
VAL A 239
ILE A 219
 None
 1.13A 6ef6A-4bxwA:
undetectable		 6ef6A-4bxwA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d1t METALLO-B-LACTAMASE

(Pseudomonas
aeruginosa) 		PF00753
(Lactamase_B) 		5 LEU A  72
ILE A  48
PRO A 277
VAL A 258
ILE A 260
 None
 1.21A 6ef6A-4d1tA:
undetectable		 6ef6A-4d1tA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fmc RORF2

(Escherichia
coli) 		PF06872
(EspG) 		5 LEU A 105
SER A 104
ARG A 120
VAL A 129
ILE A 119
 None
 0.99A 6ef6A-4fmcA:
1.4		 6ef6A-4fmcA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gbr BETA-2 ADRENERGIC
RECEPTOR

(Homo sapiens) 		PF00001
(7tm_1) 		5 LEU A  75
SER A  74
THR A 123
ILE A 127
ILE A  72
 None
 1.00A 6ef6A-4gbrA:
undetectable		 6ef6A-4gbrA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hy3 PHOSPHOGLYCERATE
OXIDOREDUCTASE

(Rhizobium etli) 		PF02826
(2-Hacid_dh_C) 		5 ILE A  21
ARG A  27
PRO A  13
VAL A  81
ILE A  59
 None
 1.10A 6ef6A-4hy3A:
undetectable		 6ef6A-4hy3A:
25.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i2w PROTEIN UNC-45

(Caenorhabditis
elegans) 		PF11701
(UNC45-central) 		5 LEU A 243
THR A 256
ILE A 209
VAL A 191
ILE A 195
 None
 1.17A 6ef6A-4i2wA:
undetectable		 6ef6A-4i2wA:
16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i8v CYTOCHROME P450 1A1

(Homo sapiens) 		PF00067
(p450) 		5 LEU A  86
SER A  87
THR A  91
PRO A  40
PHE A 399
 None
 1.28A 6ef6A-4i8vA:
undetectable		 6ef6A-4i8vA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jin RIO-TYPE
SERINE/THREONINE-PRO
TEIN KINASE RIO1

(Archaeoglobus
fulgidus) 		PF01163
(RIO1) 		5 LEU A 197
ILE A 235
PHE A 238
VAL A 179
ILE A 202
 None
 1.22A 6ef6A-4jinA:
7.7		 6ef6A-4jinA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lde LYSOZYME, BETA-2
ADRENERGIC RECEPTOR

(Homo sapiens;
Escherichia
virus T4) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		5 LEU A1075
SER A1074
THR A1123
ILE A1127
ILE A1072
 None
 1.03A 6ef6A-4ldeA:
undetectable		 6ef6A-4ldeA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ln1 L-LACTATE
DEHYDROGENASE 1

(Bacillus cereus) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		5 SER A 136
THR A 132
ILE A  79
VAL A  11
ILE A 109
 None
 1.12A 6ef6A-4ln1A:
undetectable		 6ef6A-4ln1A:
23.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mz0 CURL

(Moorea
producens) 		PF00109
(ketoacyl-synt)
PF00698
(Acyl_transf_1)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		5 LEU A 192
SER A 193
THR A 189
ILE A 158
VAL A 278
 None
 1.24A 6ef6A-4mz0A:
undetectable		 6ef6A-4mz0A:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n01 PERIPLASMIC BINDING
PROTEIN

(Veillonella
parvula) 		PF01497
(Peripla_BP_2) 		5 LEU A 230
THR A 226
ILE A 311
VAL A 306
ILE A 265
 None
 1.22A 6ef6A-4n01A:
undetectable		 6ef6A-4n01A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4obs ALPHA-L-IDURONIDASE

(Homo sapiens) 		PF01229
(Glyco_hydro_39) 		5 LEU A 261
SER A 260
ILE A 283
PRO A 342
ILE A 295
 None
 1.29A 6ef6A-4obsA:
undetectable		 6ef6A-4obsA:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q5y MATERNAL PROTEIN
TUDOR

(Drosophila
melanogaster) 		PF00567
(TUDOR) 		5 LEU A2458
THR A2462
ILE A2507
ARG A2499
PHE A2501
 None
 1.21A 6ef6A-4q5yA:
undetectable		 6ef6A-4q5yA:
24.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q6k BNR/ASP-BOX REPEAT
PROTEIN

(Bacteroides
caccae) 		PF13088
(BNR_2)
PF14873
(BNR_assoc_N) 		5 LEU A 254
SER A 255
ILE A 291
PRO A 289
VAL A 302
 None
 1.27A 6ef6A-4q6kA:
undetectable		 6ef6A-4q6kA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4upl SULFATASE FAMILY
PROTEIN

(Ruegeria
pomeroyi) 		PF00884
(Sulfatase)
PF16347
(DUF4976) 		5 LEU A 399
SER A 398
ILE A 353
VAL A  37
ILE A 402
 None
 1.21A 6ef6A-4uplA:
undetectable		 6ef6A-4uplA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ux7 PUTATIVE PEPTIDASE
C60B, SORTASE B

(Clostridioides
difficile) 		PF04203
(Sortase) 		5 LEU A 223
SER A 224
PHE A 115
VAL A  90
ILE A 130
 None
 1.29A 6ef6A-4ux7A:
undetectable		 6ef6A-4ux7A:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w8x CRISPR SYSTEM CMR
SUBUNIT CMR1-1

(Pyrococcus
furiosus) 		PF03787
(RAMPs) 		5 LEU A 143
ILE A   8
PHE A 121
VAL A 123
ILE A  32
 None
 1.20A 6ef6A-4w8xA:
undetectable		 6ef6A-4w8xA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xqk LLABIII

(Lactococcus
lactis) 		PF00271
(Helicase_C)
PF02384
(N6_Mtase)
PF04851
(ResIII)
PF13156
(Mrr_cat_2) 		5 LEU A1114
ILE A1084
PRO A 870
VAL A 873
ILE A1133
 None
 1.27A 6ef6A-4xqkA:
undetectable		 6ef6A-4xqkA:
10.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xwu INOSINE-5'-MONOPHOSP
HATE
DEHYDROGENASE,INOSIN
E-5'-MONOPHOSPHATE
DEHYDROGENASE

(Eremothecium
gossypii) 		PF00478
(IMPDH) 		5 LEU A 471
SER A 474
ILE A 380
VAL A 387
ILE A 376
 None
 1.28A 6ef6A-4xwuA:
undetectable		 6ef6A-4xwuA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y2l CFA/I FIMBRIAL
SUBUNIT B

(Escherichia
coli) 		PF04449
(Fimbrial_CS1) 		5 LEU A  31
SER A  42
ILE A  80
VAL A 139
ILE A 119
 None
 1.28A 6ef6A-4y2lA:
undetectable		 6ef6A-4y2lA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zlg PUTATIVE B-GLYCAN
PHOSPHORYLASE

(Saccharophagus
degradans) 		PF06165
(Glyco_transf_36)
PF17167
(Glyco_hydro_36) 		5 LEU A 154
SER A 155
ILE A 144
VAL A 125
ILE A  82
 None
 1.27A 6ef6A-4zlgA:
undetectable		 6ef6A-4zlgA:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a87 METALLO-BETA-LACTAMA
SE VIM-5

(Klebsiella
pneumoniae) 		PF00753
(Lactamase_B) 		5 LEU A  72
ILE A  49
PRO A 243
VAL A 235
ILE A 237
 None
 1.13A 6ef6A-5a87A:
undetectable		 6ef6A-5a87A:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d8g TRYPTOPHANASE

(Escherichia
coli) 		PF01212
(Beta_elim_lyase) 		5 LEU A 176
ILE A 222
PRO A 185
VAL A 188
ILE A 180
 None
 1.28A 6ef6A-5d8gA:
undetectable		 6ef6A-5d8gA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dem ACYL-[ACYL-CARRIER-P
ROTEIN]--UDP-N-ACETY
LGLUCOSAMINE
O-ACYLTRANSFERASE

(Pseudomonas
aeruginosa) 		PF00132
(Hexapep)
PF13720
(Acetyltransf_11) 		5 LEU A 149
SER A 150
THR A 153
ILE A 173
VAL A 177
 None
 1.07A 6ef6A-5demA:
undetectable		 6ef6A-5demA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f8u BETA-1 ADRENERGIC
RECEPTOR

(Meleagris
gallopavo) 		no annotation 5 LEU B  83
SER B  82
THR B 131
ILE B 135
ILE B  80
 None
 0.97A 6ef6A-5f8uB:
undetectable		 6ef6A-5f8uB:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gj3 PERIPLASMIC BINDING
PROTEIN

(Roseiflexus sp.
RS-1) 		PF01497
(Peripla_BP_2) 		5 LEU A 144
SER A 145
ILE A 172
PRO A 154
VAL A 157
 None
 1.14A 6ef6A-5gj3A:
undetectable		 6ef6A-5gj3A:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gj3 PERIPLASMIC BINDING
PROTEIN

(Roseiflexus sp.
RS-1) 		PF01497
(Peripla_BP_2) 		5 LEU A 144
SER A 145
THR A 168
ILE A 172
VAL A 157
 None
 1.30A 6ef6A-5gj3A:
undetectable		 6ef6A-5gj3A:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gyj PUTATIVE PEPTIDASE
C60B, SORTASE B

(Clostridioides
difficile) 		PF04203
(Sortase) 		5 LEU A 206
SER A 207
PHE A  98
VAL A  73
ILE A 113
 None
 1.30A 6ef6A-5gyjA:
undetectable		 6ef6A-5gyjA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k5z PARA

(Sulfolobus sp.
NOB8H2) 		PF13614
(AAA_31) 		5 LEU A 139
THR A  21
ILE A  24
VAL A 307
ILE A   6
 None
 1.30A 6ef6A-5k5zA:
undetectable		 6ef6A-5k5zA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kqw 4-AMINOBUTYRATE
TRANSAMINASE

(Pseudomonas) 		PF00202
(Aminotran_3) 		5 LEU A 208
ILE A 254
PRO A 217
VAL A 220
ILE A 212
 None
 1.22A 6ef6A-5kqwA:
undetectable		 6ef6A-5kqwA:
24.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kr6 4-AMINOBUTYRATE
TRANSAMINASE

(Pseudomonas) 		PF00202
(Aminotran_3) 		5 LEU A 208
ILE A 254
PRO A 217
VAL A 220
ILE A 212
 None
 1.21A 6ef6A-5kr6A:
undetectable		 6ef6A-5kr6A:
25.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l0v PROTEIN
O-GLUCOSYLTRANSFERAS
E 1

(Homo sapiens) 		PF05686
(Glyco_transf_90) 		5 LEU A  43
SER A  42
ILE A 338
VAL A 334
ILE A  39
 NAG  A1001 (-3.5A)
None
None
None
None
 1.20A 6ef6A-5l0vA:
undetectable		 6ef6A-5l0vA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m8h ATP
PHOSPHORIBOSYLTRANSF
ERASE REGULATORY
SUBUNIT

(Psychrobacter
arcticus) 		PF13393
(tRNA-synt_His) 		5 LEU A 375
SER A 376
ARG A 374
PRO A 361
ILE A 328
 None
 1.20A 6ef6A-5m8hA:
1.1		 6ef6A-5m8hA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tc3 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE

(Eremothecium
gossypii) 		PF00478
(IMPDH)
PF00571
(CBS) 		5 LEU A 471
SER A 474
ILE A 380
VAL A 387
ILE A 376
 None
 1.22A 6ef6A-5tc3A:
undetectable		 6ef6A-5tc3A:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vha DEAH
(ASP-GLU-ALA-HIS)
BOX POLYPEPTIDE 36

(Bos taurus) 		no annotation 5 LEU A 759
THR A 905
ILE A 837
VAL A 720
ILE A 833
 None
 1.30A 6ef6A-5vhaA:
undetectable		 6ef6A-5vhaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xbj FLAGELLAR
HOOK-ASSOCIATED
PROTEIN FLGK

(Campylobacter
jejuni) 		no annotation 5 LEU A 297
THR A 285
ILE A 272
VAL A 169
ILE A 165
 None
 1.24A 6ef6A-5xbjA:
0.3		 6ef6A-5xbjA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6az0 MITOCHONDRIAL INNER
MEMBRANE I-AAA
PROTEASE
SUPERCOMPLEX SUBUNIT
YME1

(Saccharomyces
cerevisiae) 		no annotation 5 LEU A 293
THR A 334
ILE A 420
VAL A 317
ILE A 296
 None
 1.18A 6ef6A-6az0A:
undetectable		 6ef6A-6az0A:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bxa VARIABLE LYMPHOCYTE
RECEPTOR 2

(Petromyzon
marinus) 		no annotation 5 LEU C  72
SER C  71
PRO C  23
VAL C  33
ILE C  47
 None
 1.17A 6ef6A-6bxaC:
undetectable		 6ef6A-6bxaC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d5i PHOSPHOENOLPYRUVATE
CARBOXYKINASE (ATP)

(Escherichia
coli) 		no annotation 5 LEU A 467
SER A 466
ILE A 458
VAL A 439
ILE A 462
 None
 0.97A 6ef6A-6d5iA:
undetectable		 6ef6A-6d5iA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6e29 -

(-) 		no annotation 5 LEU D 196
SER D 209
ILE D 217
ARG D 195
ILE D 212
 None
 1.25A 6ef6A-6e29D:
undetectable		 6ef6A-6e29D:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f42 DNA-DIRECTED RNA
POLYMERASE III
SUBUNIT RPC2

(Saccharomyces
cerevisiae) 		no annotation 5 LEU B 497
THR B 518
ILE B 608
ARG B 610
VAL B 372
 None
 1.15A 6ef6A-6f42B:
undetectable		 6ef6A-6f42B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f85 CYTOCHROME P450
CYP260A1

(Sorangium
cellulosum) 		no annotation 5 LEU A 184
THR A 151
ILE A 227
VAL A 223
ILE A 185
 None
 1.23A 6ef6A-6f85A:
undetectable		 6ef6A-6f85A:
undetectable