SIMILAR PATTERNS OF AMINO ACIDS FOR 6EF6_A_ACTA405_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gmv UREE

(Klebsiella
aerogenes) 		PF02814
(UreE_N)
PF05194
(UreE_C) 		4 ARG A  51
PRO A 131
GLN A 100
ILE A  22
 None
 1.16A 6ef6A-1gmvA:
0.1		 6ef6A-1gmvA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hxj BETA-GLUCOSIDASE

(Zea mays) 		PF00232
(Glyco_hydro_1) 		4 THR A 329
ARG A 331
PRO A 367
ILE A 374
 None
 1.41A 6ef6A-1hxjA:
0.0		 6ef6A-1hxjA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mw9 DNA TOPOISOMERASE I

(Escherichia
coli) 		PF01131
(Topoisom_bac)
PF01751
(Toprim) 		4 THR X 543
ARG X 195
GLN X 197
ILE X 491
 None
 1.41A 6ef6A-1mw9X:
undetectable		 6ef6A-1mw9X:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ocm MALONAMIDASE E2

(Bradyrhizobium
japonicum) 		PF01425
(Amidase) 		4 ARG A 113
PRO A 274
GLN A 277
ARG A 363
 POP  A1155 (-4.0A)
None
POP  A1155 ( 4.7A)
None
 1.45A 6ef6A-1ocmA:
0.0		 6ef6A-1ocmA:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sqe HYPOTHETICAL PROTEIN
PG130

(Staphylococcus
aureus) 		PF03992
(ABM) 		4 THR A  34
ARG A  37
GLN A 104
ILE A 108
 None
 1.41A 6ef6A-1sqeA:
undetectable		 6ef6A-1sqeA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wue MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY PROTEIN

(Enterococcus
faecalis) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 PRO A1309
GLN A1308
ARG A1128
ILE A1131
 None
 1.48A 6ef6A-1wueA:
0.0		 6ef6A-1wueA:
25.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ycn PUTATIVE
CA2+-DEPENDENT
MEMBRANE-BINDING
PROTEIN ANNEXIN

(Arabidopsis
thaliana) 		PF00191
(Annexin) 		4 THR A 271
ARG A 272
PRO A  84
GLN A 117
 None
 1.43A 6ef6A-1ycnA:
0.0		 6ef6A-1ycnA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z7e PROTEIN ARNA

(Escherichia
coli) 		PF00551
(Formyl_trans_N)
PF01370
(Epimerase)
PF02911
(Formyl_trans_C) 		4 THR A 486
ARG A 426
PRO A 430
ILE A 550
 None
 1.41A 6ef6A-1z7eA:
0.0		 6ef6A-1z7eA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c5q RRAA-LIKE PROTEIN
YER010C

(Saccharomyces
cerevisiae) 		PF03737
(RraA-like) 		4 PRO A 186
GLN A 188
ARG A 184
ILE A 169
 EDO  A1234 ( 4.7A)
CME  A 170 ( 3.3A)
EDO  A1234 (-2.7A)
CME  A 170 ( 3.9A)
 1.33A 6ef6A-2c5qA:
0.0		 6ef6A-2c5qA:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dku KIAA1556 PROTEIN

(Homo sapiens) 		PF07679
(I-set) 		4 THR A  32
PRO A  35
GLN A  58
ILE A  82
 None
 1.46A 6ef6A-2dkuA:
undetectable		 6ef6A-2dkuA:
14.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hnh DNA POLYMERASE III
ALPHA SUBUNIT

(Escherichia
coli) 		PF02811
(PHP)
PF07733
(DNA_pol3_alpha)
PF14579
(HHH_6) 		4 THR A 173
PRO A 176
ARG A 135
ILE A 171
 None
None
PO4  A 911 (-4.1A)
PO4  A 911 (-4.3A)
 1.32A 6ef6A-2hnhA:
undetectable		 6ef6A-2hnhA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i4n PROLINE-TRNA LIGASE

(Rhodopseudomonas
palustris) 		PF00587
(tRNA-synt_2b)
PF03129
(HGTP_anticodon) 		4 THR A 109
ARG A 140
ARG A  85
ILE A 202
 5CA  A 439 (-3.6A)
5CA  A 439 (-2.8A)
None
5CA  A 439 (-4.2A)
 1.25A 6ef6A-2i4nA:
0.9		 6ef6A-2i4nA:
25.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ilr FANCONI ANEMIA GROUP
E PROTEIN

(Homo sapiens) 		PF11510
(FA_FANCE) 		4 THR A 450
PRO A 445
GLN A 408
ILE A 441
 None
 1.42A 6ef6A-2ilrA:
undetectable		 6ef6A-2ilrA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r63 REPRESSOR PROTEIN
FROM BACTERIOPHAGE
434

(Escherichia
virus Lambda) 		PF01381
(HTH_3) 		4 THR A  26
PRO A  42
GLN A  33
ILE A  31
 None
 1.32A 6ef6A-2r63A:
undetectable		 6ef6A-2r63A:
9.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zou SPONDIN-1

(Homo sapiens) 		PF02014
(Reeler) 		4 THR A  59
GLN A 165
ARG A 167
ILE A 169
 EDO  A   6 ( 4.0A)
None
None
EDO  A   6 (-4.4A)
 1.01A 6ef6A-2zouA:
undetectable		 6ef6A-2zouA:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a18 ALDOXIME DEHYDRATASE

(Rhodococcus
erythropolis) 		PF13816
(Dehydratase_hem) 		4 ARG A 132
PRO A  76
GLN A 105
ILE A 114
 None
 1.08A 6ef6A-3a18A:
0.3		 6ef6A-3a18A:
26.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cos ALCOHOL
DEHYDROGENASE 4

(Homo sapiens) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 THR A   3
GLN A  40
ARG A  38
ILE A   8
 None
 1.47A 6ef6A-3cosA:
undetectable		 6ef6A-3cosA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gb0 PEPTIDASE T

(Bacillus cereus) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		4 THR A 224
ARG A 218
PRO A 177
GLN A 317
 None
PEG  A 377 ( 4.0A)
None
None
 1.40A 6ef6A-3gb0A:
undetectable		 6ef6A-3gb0A:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hlz UNCHARACTERIZED
PROTEIN BT_1490

(Bacteroides
thetaiotaomicron) 		PF12712
(DUF3805)
PF12713
(DUF3806) 		4 ARG A 132
PRO A   9
ARG A 146
ILE A 143
 None
 1.47A 6ef6A-3hlzA:
1.8		 6ef6A-3hlzA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iu1 GLYCYLPEPTIDE
N-TETRADECANOYLTRANS
FERASE 1

(Homo sapiens) 		PF01233
(NMT)
PF02799
(NMT_C) 		4 THR A 238
PRO A 137
GLN A 278
ILE A 235
 None
 1.21A 6ef6A-3iu1A:
undetectable		 6ef6A-3iu1A:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3izy TRANSLATION
INITIATION FACTOR
IF-2, MITOCHONDRIAL

(Bos taurus) 		PF00009
(GTP_EFTU)
PF11987
(IF-2) 		4 THR P 252
PRO P 181
ARG P 179
ILE P 375
 None
 1.27A 6ef6A-3izyP:
undetectable		 6ef6A-3izyP:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jyo QUINATE/SHIKIMATE
DEHYDROGENASE

(Corynebacterium
glutamicum) 		PF08501
(Shikimate_dh_N) 		4 THR A 267
GLN A  30
ARG A  32
ILE A   5
 None
 1.01A 6ef6A-3jyoA:
undetectable		 6ef6A-3jyoA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k6i T-CADHERIN

(Gallus gallus) 		PF00028
(Cadherin) 		4 THR A  62
PRO A  64
GLN A  13
ILE A  49
 None
 1.46A 6ef6A-3k6iA:
undetectable		 6ef6A-3k6iA:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lto MEVALONATE
DIPHOSPHATE
DECARBOXYLASE

(Legionella
pneumophila) 		no annotation 4 THR A 215
ARG A 219
PRO A 211
GLN A 252
 None
 1.39A 6ef6A-3ltoA:
undetectable		 6ef6A-3ltoA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mx3 SUSD HOMOLOG

(Bacteroides
fragilis) 		PF12771
(SusD-like_2) 		4 THR A 446
ARG A 445
PRO A 449
ILE A 420
 None
 1.16A 6ef6A-3mx3A:
undetectable		 6ef6A-3mx3A:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qki GLUCOSE-6-PHOSPHATE
ISOMERASE

(Plasmodium
falciparum) 		PF00342
(PGI) 		4 ARG A 518
PRO A 424
GLN A 399
ILE A 360
 None
 1.14A 6ef6A-3qkiA:
undetectable		 6ef6A-3qkiA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rh8 VIVID PAS PROTEIN
VVD

(Neurospora
crassa) 		PF13426
(PAS_9) 		4 PRO B  60
GLN B  61
ARG B  57
ILE B 166
 None
 1.38A 6ef6A-3rh8B:
undetectable		 6ef6A-3rh8B:
16.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3va6 TWO-COMPONENT SYSTEM
SENSOR HISTIDINE
KINASE

(Bacteroides
thetaiotaomicron) 		PF07494
(Reg_prop)
PF07495
(Y_Y_Y) 		4 THR A 236
PRO A 210
GLN A 252
ILE A 234
 None
 1.35A 6ef6A-3va6A:
undetectable		 6ef6A-3va6A:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3x0y DSZC

(Rhodococcus
erythropolis) 		PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N)
PF08028
(Acyl-CoA_dh_2) 		4 THR A  99
PRO A 252
GLN A 255
ILE A 257
 None
 1.40A 6ef6A-3x0yA:
3.2		 6ef6A-3x0yA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a0x TRANSCRIPTION FACTOR
FAPR

(Staphylococcus
aureus) 		PF03061
(4HBT) 		4 ARG A  18
PRO A  25
ARG A  58
ILE A  52
 None
 1.47A 6ef6A-4a0xA:
undetectable		 6ef6A-4a0xA:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a4z ANTIVIRAL HELICASE
SKI2

(Saccharomyces
cerevisiae) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF08148
(DSHCT)
PF13234
(rRNA_proc-arch) 		4 THR A 353
ARG A 504
PRO A 732
ARG A 763
 ANP  A2288 (-3.5A)
None
None
ANP  A2288 (-3.5A)
 1.21A 6ef6A-4a4zA:
undetectable		 6ef6A-4a4zA:
15.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ci0 F420-REDUCING
HYDROGENASE, SUBUNIT
ALPHA
F420-REDUCING
HYDROGENASE, SUBUNIT
GAMMA
F420-REDUCING
HYDROGENASE, SUBUNIT
BETA

(Methanothermobacter
marburgensis;
Methanothermobacter
marburgensis;
Methanothermobacter
marburgensis) 		PF00374
(NiFeSe_Hases)
PF00037
(Fer4)
PF01058
(Oxidored_q6)
PF04422
(FrhB_FdhB_N)
PF04432
(FrhB_FdhB_C) 		4 ARG A 134
PRO B 175
ARG C 120
ILE A 149
 None
 1.34A 6ef6A-4ci0A:
undetectable		 6ef6A-4ci0A:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f0i HIGH AFFINITY NERVE
GROWTH FACTOR
RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 THR A 704
PRO A 767
GLN A 768
ARG A 770
 None
 1.20A 6ef6A-4f0iA:
undetectable		 6ef6A-4f0iA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k9s GDSL-LIKE
LIPASE/ACYLHYDROLASE
FAMILY PROTEIN

(Neisseria
meningitidis) 		PF00657
(Lipase_GDSL) 		4 THR A  71
PRO A 223
GLN A 165
ARG A 166
 None
 1.41A 6ef6A-4k9sA:
undetectable		 6ef6A-4k9sA:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mif PYRANOSE 2-OXIDASE

(Phanerochaete
chrysosporium) 		PF05199
(GMC_oxred_C) 		4 ARG A 498
PRO A 506
GLN A 339
ILE A 371
 None
 1.39A 6ef6A-4mifA:
undetectable		 6ef6A-4mifA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mru SUSD HOMOLOG

(Bacteroides
thetaiotaomicron) 		PF12741
(SusD-like) 		4 ARG A 458
PRO A 150
GLN A 175
ILE A 147
 None
 1.07A 6ef6A-4mruA:
undetectable		 6ef6A-4mruA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n6v CYSTATIN-B

(Homo sapiens) 		no annotation 4 THR 2  16
PRO 2  11
GLN 2  10
ILE 2  55
 None
 1.25A 6ef6A-4n6v2:
2.4		 6ef6A-4n6v2:
12.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oer NIKA PROTEIN

(Brucella suis) 		PF00496
(SBP_bac_5) 		4 THR A 226
PRO A 200
ARG A 203
ILE A 215
 None
 1.16A 6ef6A-4oerA:
0.9		 6ef6A-4oerA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rgp CSM6_III-A

(Streptococcus
mutans) 		PF09659
(Cas_Csm6) 		4 THR A 173
PRO A 176
GLN A 177
ILE A 170
 None
 1.23A 6ef6A-4rgpA:
undetectable		 6ef6A-4rgpA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tma DNA GYRASE SUBUNIT B

(Escherichia
coli) 		PF00986
(DNA_gyraseB_C)
PF01751
(Toprim) 		4 PRO B 613
GLN B 612
ARG B 698
ILE B 610
 None
 1.44A 6ef6A-4tmaB:
undetectable		 6ef6A-4tmaB:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4udr GLUCOSE-METHANOL-CHO
LINE OXIDOREDUCTASE

(Methylovorus
sp. MP688) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		4 THR A 347
ARG A 112
PRO A 373
ARG A 405
 None
 1.43A 6ef6A-4udrA:
undetectable		 6ef6A-4udrA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uyb SEC14-LIKE PROTEIN 3

(Homo sapiens) 		PF00650
(CRAL_TRIO) 		4 THR A 123
ARG A 126
GLN A  75
ILE A  80
 None
 1.36A 6ef6A-4uybA:
undetectable		 6ef6A-4uybA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4woq N-ACETYLNEURAMINATE
LYASE

(Clostridioides
difficile) 		PF00701
(DHDPS) 		4 THR A 234
PRO A 206
GLN A 246
ILE A 239
 None
 1.16A 6ef6A-4woqA:
undetectable		 6ef6A-4woqA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x6g OXYR

(Pseudomonas
aeruginosa) 		PF00126
(HTH_1)
PF03466
(LysR_substrate) 		4 THR A 129
PRO A 149
GLN A 203
ILE A 146
 PEO  A 401 (-3.7A)
None
None
None
 1.43A 6ef6A-4x6gA:
undetectable		 6ef6A-4x6gA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xk8 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Pisum sativum) 		PF02605
(PsaL) 		4 THR L  41
ARG L  48
PRO L 112
GLN L 127
 None
 1.00A 6ef6A-4xk8L:
undetectable		 6ef6A-4xk8L:
17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y0m OXYR

(Pseudomonas
aeruginosa) 		PF03466
(LysR_substrate) 		4 THR A 129
PRO A 149
GLN A 203
ILE A 146
 None
 1.44A 6ef6A-4y0mA:
undetectable		 6ef6A-4y0mA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y85 MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 8

(Homo sapiens) 		PF00069
(Pkinase) 		4 ARG A 330
PRO A 332
ARG A 333
ILE A 342
 None
 1.36A 6ef6A-4y85A:
6.4		 6ef6A-4y85A:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yt9 PEPTIDYLARGININE
DEIMINASE

(Porphyromonas
gingivalis) 		PF04371
(PAD_porph) 		4 THR A 123
PRO A  72
GLN A  98
ILE A  92
 None
 0.93A 6ef6A-4yt9A:
undetectable		 6ef6A-4yt9A:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a6b N-ACETYL-BETA-D-GLUC
OSAMINIDASE

(Streptococcus
pneumoniae) 		PF00728
(Glyco_hydro_20) 		4 THR D 412
PRO D 387
GLN D 390
ILE D 109
 None
 1.28A 6ef6A-5a6bD:
undetectable		 6ef6A-5a6bD:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b4w PLEXIN-B1

(Homo sapiens) 		PF01403
(Sema)
PF01437
(PSI) 		4 THR A 173
ARG A 170
GLN A 116
ARG A  77
 None
 1.25A 6ef6A-5b4wA:
undetectable		 6ef6A-5b4wA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b7s CYSTEINE DESULFURASE

(Thermococcus
onnurineus) 		PF00266
(Aminotran_5) 		4 THR A 109
PRO A 120
GLN A 122
ILE A 107
 None
 1.30A 6ef6A-5b7sA:
undetectable		 6ef6A-5b7sA:
23.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cyr RNA-DEPENDENT RNA
POLYMERASE

(Thosea asigna
virus) 		no annotation 4 ARG B  42
PRO B  46
GLN B  47
ILE B 587
 None
 1.49A 6ef6A-5cyrB:
undetectable		 6ef6A-5cyrB:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fur TRANSCRIPTION
INITIATION FACTOR
TFIID SUBUNIT 6

(Homo sapiens) 		PF07571
(TAF6_C) 		4 THR J 372
ARG J 330
GLN J 316
ARG J 315
 None
 1.15A 6ef6A-5furJ:
undetectable		 6ef6A-5furJ:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5it0 PHOSPHOSERINE
PHOSPHATASE

(Mycobacterium
avium) 		PF12710
(HAD)
PF13740
(ACT_6) 		4 THR A 259
ARG A 262
ARG A 390
ILE A 393
 None
 1.36A 6ef6A-5it0A:
undetectable		 6ef6A-5it0A:
23.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k59 UNCHARACTERIZED
LEUKOCIDIN-LIKE
PROTEIN 2

(Staphylococcus
aureus) 		no annotation 4 THR D 217
ARG D 215
PRO D 277
ILE D 219
 None
 1.41A 6ef6A-5k59D:
0.8		 6ef6A-5k59D:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kca CEREBELLIN-1,CEREBEL
LIN-1,CEREBELLIN-1,G
LUTAMATE RECEPTOR
IONOTROPIC, DELTA-2

(Homo sapiens) 		PF00386
(C1q)
PF01094
(ANF_receptor) 		4 PRO A 777
GLN A 782
ARG A 783
ILE A 780
 None
 1.46A 6ef6A-5kcaA:
undetectable		 6ef6A-5kcaA:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kvr PYRUVATE
DEHYDROGENASE
COMPLEX REPRESSOR

(Escherichia
coli) 		PF00392
(GntR) 		4 THR A  72
ARG A  66
PRO A  35
ILE A  55
 None
 1.47A 6ef6A-5kvrA:
undetectable		 6ef6A-5kvrA:
15.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kvr PYRUVATE
DEHYDROGENASE
COMPLEX REPRESSOR

(Escherichia
coli) 		PF00392
(GntR) 		4 THR A  72
ARG A  66
PRO A  36
ILE A  55
 None
 1.16A 6ef6A-5kvrA:
undetectable		 6ef6A-5kvrA:
15.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kvu ISOCITRATE
DEHYDROGENASE

(Mycobacterium
tuberculosis) 		PF03971
(IDH) 		4 THR A 259
PRO A 346
GLN A  94
ILE A 350
 None
None
NAP  A 801 ( 4.3A)
NAP  A 801 (-3.6A)
 1.30A 6ef6A-5kvuA:
undetectable		 6ef6A-5kvuA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l9w ACETOPHENONE
CARBOXYLASE GAMMA
SUBUNIT
ACETOPHENONE
CARBOXYLASE ALPHA
SUBUNIT

(Aromatoleum
aromaticum;
Aromatoleum
aromaticum) 		PF01968
(Hydantoinase_A)
PF05378
(Hydant_A_N)
PF01968
(Hydantoinase_A)
PF05378
(Hydant_A_N) 		4 THR b 203
ARG b 140
GLN B 241
ARG B 238
 None
 1.26A 6ef6A-5l9wb:
undetectable		 6ef6A-5l9wb:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ls6 HISTONE-LYSINE
N-METHYLTRANSFERASE
EZH2,HISTONE-LYSINE
N-METHYLTRANSFERASE
EZH2,HISTONE-LYSINE
N-METHYLTRANSFERASE
EZH2

(Homo sapiens) 		PF00856
(SET)
PF11616
(EZH2_WD-Binding) 		4 THR A  53
GLN A  47
ARG A  46
ILE A  49
 None
 1.37A 6ef6A-5ls6A:
undetectable		 6ef6A-5ls6A:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o34 ENOYL-COA HYDRATASE
CARB HOMOLOGUE

(Streptomyces
cattleya) 		no annotation 4 PRO A 141
GLN A 249
ARG A 252
ILE A 138
 None
 1.38A 6ef6A-5o34A:
undetectable		 6ef6A-5o34A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ovn POL PROTEIN
POL PROTEIN

(Feline
immunodeficiency
virus;
Feline
immunodeficiency
virus) 		no annotation
no annotation 		4 THR B 364
ARG B 356
PRO A 411
ILE A 403
 None
 1.42A 6ef6A-5ovnB:
undetectable		 6ef6A-5ovnB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5te7 HIV-1 GP120 CORE

(Human
immunodeficiency
virus 1) 		PF00516
(GP120) 		4 PRO G 299
GLN G 328
ARG G 298
ILE G 326
 None
 1.32A 6ef6A-5te7G:
undetectable		 6ef6A-5te7G:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u81 ACID CERAMIDASE
ISOFORM B

(Heterocephalus
glaber) 		no annotation 4 THR A 144
PRO A 336
GLN A 338
ILE A 146
 None
 1.26A 6ef6A-5u81A:
undetectable		 6ef6A-5u81A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ufy ACYLTRANSFERASE

(Streptococcus
pneumoniae) 		no annotation 4 THR A 517
GLN A 555
ARG A 539
ILE A 550
 None
 1.20A 6ef6A-5ufyA:
undetectable		 6ef6A-5ufyA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y1a -

(-) 		no annotation 4 THR A 186
PRO A 170
GLN A 174
ILE A  63
 None
 1.33A 6ef6A-5y1aA:
undetectable		 6ef6A-5y1aA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ck0 BIOTIN ACETYL
COENZYME A
CARBOXYLASE
SYNTHETASE

(Helicobacter
pylori) 		no annotation 4 THR A  17
PRO A  13
GLN A  39
ILE A  43
 None
None
F5D  A 301 (-3.0A)
F5D  A 301 (-4.0A)
 1.49A 6ef6A-6ck0A:
1.2		 6ef6A-6ck0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f8y THREONYLCARBAMOYL-AM
P SYNTHASE

(Pyrococcus
abyssi) 		no annotation 4 ARG A 195
PRO A  96
ARG A 121
ILE A  65
 THR  A 401 (-3.5A)
None
THR  A 401 (-3.1A)
THR  A 401 (-4.4A)
 1.19A 6ef6A-6f8yA:
undetectable		 6ef6A-6f8yA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fuy VINCULIN

(Homo sapiens) 		no annotation 4 THR A 993
PRO A  15
GLN A  18
ILE A 997
 None
 1.34A 6ef6A-6fuyA:
1.6		 6ef6A-6fuyA:
undetectable