SIMILAR PATTERNS OF AMINO ACIDS FOR 6ECX_A_SAMA1301_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a5l UREASE (ALPHA
SUBUNIT)

(Klebsiella
aerogenes) 		PF00449
(Urease_alpha)
PF01979
(Amidohydro_1) 		4 THR C 267
ARG C 518
THR C 133
ASP C 360
 None
 1.34A 6ecxA-1a5lC:
undetectable		 6ecxA-1a5lC:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c30 CARBAMOYL PHOSPHATE
SYNTHETASE: LARGE
SUBUNIT

(Escherichia
coli) 		PF02142
(MGS)
PF02786
(CPSase_L_D2)
PF02787
(CPSase_L_D3) 		4 THR A 173
THR A 244
GLN A 285
ASP A 238
 CL  A4012 (-4.5A)
K  A4017 ( 3.5A)
MN  A4002 ( 2.5A)
None
 1.43A 6ecxA-1c30A:
3.0		 6ecxA-1c30A:
14.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e9y UREASE SUBUNIT BETA

(Helicobacter
pylori) 		PF00449
(Urease_alpha)
PF01979
(Amidohydro_1) 		4 THR B 269
ARG B 520
THR B 135
ASP B 362
 None
None
None
HAE  B 800 ( 2.5A)
 1.40A 6ecxA-1e9yB:
undetectable		 6ecxA-1e9yB:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fok PROTEIN (FOKI
RESTRICTION
ENDONUCLEASE)

(Planomicrobium
okeanokoites) 		PF02980
(FokI_C)
PF02981
(FokI_N)
PF09254
(Endonuc-FokI_C)
PF16902
(Type2_restr_D3) 		4 THR A 468
THR A 193
GLN A 420
ASP A 224
 None
 1.43A 6ecxA-1fokA:
undetectable		 6ecxA-1fokA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i2o TRANSALDOLASE B

(Escherichia
coli) 		PF00923
(TAL_FSA) 		4 THR A  34
THR A  74
GLN A 306
ASP A  72
 None
 1.05A 6ecxA-1i2oA:
undetectable		 6ecxA-1i2oA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jqo PHOSPHOENOLPYRUVATE
CARBOXYLASE

(Zea mays) 		PF00311
(PEPcase) 		4 THR A 652
THR A 175
GLN A 673
ASP A 454
 None
 1.28A 6ecxA-1jqoA:
undetectable		 6ecxA-1jqoA:
17.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n3s GTP CYCLOHYDROLASE I

(Escherichia
coli) 		PF01227
(GTP_cyclohydroI) 		4 THR A 109
THR A 105
GLN A 142
ASP A 103
 None
 1.46A 6ecxA-1n3sA:
undetectable		 6ecxA-1n3sA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nug PROTEIN-GLUTAMINE
GLUTAMYLTRANSFERASE
E

(Homo sapiens) 		PF00868
(Transglut_N)
PF00927
(Transglut_C)
PF01841
(Transglut_core) 		4 THR A 398
ARG A 396
THR A 519
ASP A 536
 None
 1.25A 6ecxA-1nugA:
undetectable		 6ecxA-1nugA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rcy RUSTICYANIN

(Acidithiobacillus
ferrooxidans) 		PF00127
(Copper-bind) 		4 THR A  75
THR A  11
GLN A  14
ASP A 117
 None
 1.49A 6ecxA-1rcyA:
undetectable		 6ecxA-1rcyA:
17.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1suj CONE ARRESTIN

(Ambystoma
tigrinum) 		PF00339
(Arrestin_N)
PF02752
(Arrestin_C) 		4 THR A 295
THR A 236
GLN A 234
ASP A 244
 None
 1.27A 6ecxA-1sujA:
undetectable		 6ecxA-1sujA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t98 CHROMOSOME PARTITION
PROTEIN MUKF

(Escherichia
coli) 		PF03882
(KicB)
PF17192
(MukF_M) 		4 THR A 174
ARG A 124
GLN A 219
ASP A 227
 None
 1.29A 6ecxA-1t98A:
undetectable		 6ecxA-1t98A:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wi1 CALCIUM-DEPENDENT
ACTIVATOR PROTEIN
FOR SECRETION, CAPS

(Homo sapiens) 		PF00169
(PH) 		4 THR A  66
THR A 109
GLN A 111
ASP A  59
 None
 1.26A 6ecxA-1wi1A:
undetectable		 6ecxA-1wi1A:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xkw FE(III)-PYOCHELIN
RECEPTOR

(Pseudomonas
aeruginosa) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		4 THR A 387
ARG A 458
THR A 434
ASP A 465
 None
 1.24A 6ecxA-1xkwA:
undetectable		 6ecxA-1xkwA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2omv INTERNALIN-A

(Listeria
monocytogenes) 		PF08191
(LRR_adjacent)
PF12354
(Internalin_N)
PF12799
(LRR_4) 		4 THR A 148
ARG A 168
THR A  80
GLN A  82
 None
 1.41A 6ecxA-2omvA:
undetectable		 6ecxA-2omvA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p82 CYSTEINE PROTEASE
ATG4A

(Homo sapiens) 		PF03416
(Peptidase_C54) 		4 THR A 299
ARG A  58
THR A 294
GLN A 112
 None
 1.21A 6ecxA-2p82A:
undetectable		 6ecxA-2p82A:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pg3 QUEUOSINE
BIOSYNTHESIS PROTEIN
QUEC

(Pectobacterium
atrosepticum) 		PF06508
(QueC) 		4 THR A 185
ARG A 206
GLN A 177
ASP A  24
 None
 1.36A 6ecxA-2pg3A:
1.8		 6ecxA-2pg3A:
25.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pny ISOPENTENYL-DIPHOSPH
ATE DELTA-ISOMERASE
2

(Homo sapiens) 		PF00293
(NUDIX) 		4 ARG A 110
THR A 168
GLN A  68
ASP A  72
 None
 1.26A 6ecxA-2pnyA:
undetectable		 6ecxA-2pnyA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qe6 UNCHARACTERIZED
PROTEIN TFU_2867

(Thermobifida
fusca) 		PF04672
(Methyltransf_19) 		4 THR A  89
ARG A  61
THR A 129
ASP A 147
 None
SAM  A 400 (-3.7A)
None
None
 1.40A 6ecxA-2qe6A:
10.7		 6ecxA-2qe6A:
23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qry THIAMINE-BINDING
PERIPLASMIC PROTEIN

(Escherichia
coli) 		PF13343
(SBP_bac_6) 		4 THR A 216
THR A 162
GLN A 243
ASP A  59
 None
TPS  A 400 (-3.9A)
TPS  A 400 ( 4.7A)
TPS  A 400 (-3.7A)
 1.40A 6ecxA-2qryA:
undetectable		 6ecxA-2qryA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b6v KINESIN-LIKE PROTEIN
KIF3C

(Homo sapiens) 		PF00225
(Kinesin) 		4 THR A 101
THR A  34
GLN A  31
ASP A  36
 ADP  A1001 (-4.9A)
None
UNX  A1003 ( 4.7A)
None
 1.42A 6ecxA-3b6vA:
undetectable		 6ecxA-3b6vA:
24.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3euf URIDINE
PHOSPHORYLASE 1

(Homo sapiens) 		PF01048
(PNP_UDP_1) 		4 THR A 271
THR A 210
GLN A 217
ASP A 160
 None
None
BAU  A 400 (-3.1A)
None
 1.43A 6ecxA-3eufA:
undetectable		 6ecxA-3eufA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lpp SUCRASE-ISOMALTASE

(Homo sapiens) 		PF00088
(Trefoil)
PF01055
(Glyco_hydro_31)
PF16863
(NtCtMGAM_N) 		4 THR A 284
THR A 510
GLN A 522
ASP A 231
 None
 1.45A 6ecxA-3lppA:
undetectable		 6ecxA-3lppA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nqi PUTATIVE LIPOPROTEIN

(Bacteroides
fragilis) 		no annotation 4 THR A 144
ARG A  69
THR A 107
ASP A 116
 None
 1.15A 6ecxA-3nqiA:
undetectable		 6ecxA-3nqiA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o0y LIPOPROTEIN

(Colwellia
psychrerythraea) 		PF05960
(DUF885) 		4 THR A 244
THR A 235
GLN A 238
ASP A 232
 None
 1.44A 6ecxA-3o0yA:
undetectable		 6ecxA-3o0yA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p0f URIDINE
PHOSPHORYLASE 2

(Homo sapiens) 		PF01048
(PNP_UDP_1) 		4 THR A 277
THR A 216
GLN A 223
ASP A 166
 None
None
BAU  A 400 (-3.1A)
None
 1.43A 6ecxA-3p0fA:
undetectable		 6ecxA-3p0fA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qpf PUTATIVE
UNCHARACTERIZED
PROTEIN

(Streptococcus
pneumoniae) 		PF06824
(Glyco_hydro_125) 		4 THR A  84
THR A  53
GLN A  67
ASP A  55
 None
 1.42A 6ecxA-3qpfA:
undetectable		 6ecxA-3qpfA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3um6 BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE

(Plasmodium
falciparum) 		PF00186
(DHFR_1)
PF00303
(Thymidylat_synt) 		4 THR A 215
THR A 592
GLN A 594
ASP A 590
 None
 1.45A 6ecxA-3um6A:
1.7		 6ecxA-3um6A:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vta CUCUMISIN

(Cucumis melo) 		PF00082
(Peptidase_S8) 		4 THR A 112
ARG A 332
THR A 208
ASP A 200
 None
 1.42A 6ecxA-3vtaA:
undetectable		 6ecxA-3vtaA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zg6 NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-6

(Homo sapiens) 		PF02146
(SIR2) 		4 THR A 242
ARG A 251
THR A  55
ASP A 114
 None
None
APR  A1296 ( 3.1A)
None
 1.33A 6ecxA-3zg6A:
2.9		 6ecxA-3zg6A:
24.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4du6 GTP CYCLOHYDROLASE 1

(Yersinia pestis) 		PF01227
(GTP_cyclohydroI) 		4 THR A 108
THR A 104
GLN A 141
ASP A 102
 None
 1.43A 6ecxA-4du6A:
undetectable		 6ecxA-4du6A:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eqm PROTEIN KINASE

(Staphylococcus
aureus) 		PF00069
(Pkinase) 		4 THR A 249
THR A 230
GLN A 239
ASP A 236
 None
 1.25A 6ecxA-4eqmA:
undetectable		 6ecxA-4eqmA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h7o SERINE
ACETYLTRANSFERASE

(Vibrio cholerae) 		PF00132
(Hexapep)
PF06426
(SATase_N) 		4 THR A 167
ARG A 192
THR A 130
GLN A 133
 None
CYS  A 301 (-3.8A)
None
None
 1.45A 6ecxA-4h7oA:
undetectable		 6ecxA-4h7oA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jqt PUTATIVE GLYCOSYL
HYDROLASE

(Bacteroides
thetaiotaomicron) 		PF06439
(DUF1080) 		4 THR A 216
ARG A 161
GLN A  20
ASP A 203
 None
EDO  A 505 ( 3.6A)
None
None
 1.27A 6ecxA-4jqtA:
undetectable		 6ecxA-4jqtA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kh3 ANTIGEN 43

(Escherichia
coli) 		PF16168
(AIDA) 		4 THR A 163
THR A  97
GLN A 105
ASP A  79
 None
 1.32A 6ecxA-4kh3A:
undetectable		 6ecxA-4kh3A:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mae METHANOL
DEHYDROGENASE

(Methylacidiphilum
fumariolicum) 		PF13360
(PQQ_2) 		4 THR A 222
THR A 275
GLN A 291
ASP A 301
 None
None
None
CE  A 601 ( 2.3A)
 1.39A 6ecxA-4maeA:
undetectable		 6ecxA-4maeA:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pbq PUTATIVE TRAP
PERIPLASMIC SOLUTE
BINDING PROTEIN

(Haemophilus
influenzae) 		PF03480
(DctP) 		4 THR A 243
THR A  90
GLN A 238
ASP A  74
 None
 1.49A 6ecxA-4pbqA:
undetectable		 6ecxA-4pbqA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q1q ADHESIN/INVASIN TIBA
AUTOTRANSPORTER

(Escherichia
coli) 		PF16168
(AIDA) 		4 THR A 139
THR A  82
GLN A  90
ASP A  58
 None
 1.36A 6ecxA-4q1qA:
undetectable		 6ecxA-4q1qA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ry1 PERIPLASMIC SOLUTE
BINDING PROTEIN

(Pectobacterium
atrosepticum) 		PF13416
(SBP_bac_8) 		4 THR A 201
THR A 301
GLN A 209
ASP A 167
 None
None
GOL  A 503 ( 4.6A)
None
 1.50A 6ecxA-4ry1A:
undetectable		 6ecxA-4ry1A:
24.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ah0 LIPASE

(Pelosinus
fermentans) 		no annotation 4 THR A 182
THR A 279
GLN A 338
ASP A 368
 None
 1.45A 6ecxA-5ah0A:
1.7		 6ecxA-5ah0A:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d79 BERBERINE BRIDGE
ENZYME-LIKE PROTEIN

(Arabidopsis
thaliana) 		PF01565
(FAD_binding_4)
PF08031
(BBE) 		4 THR A 152
ARG A 358
THR A 106
ASP A 522
 None
None
FAD  A 603 (-4.4A)
None
 1.00A 6ecxA-5d79A:
undetectable		 6ecxA-5d79A:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5es6 LINEAR GRAMICIDIN
SYNTHASE SUBUNIT A

(Brevibacillus
parabrevis) 		PF00501
(AMP-binding)
PF00551
(Formyl_trans_N) 		4 ARG A 376
THR A 204
GLN A 207
ASP A 343
 None
 1.35A 6ecxA-5es6A:
2.0		 6ecxA-5es6A:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gne LEUCINE
AMINOPEPTIDASE

(Legionella
pneumophila) 		PF04389
(Peptidase_M28) 		4 THR A 367
THR A 356
GLN A 289
ASP A 359
 None
 1.47A 6ecxA-5gneA:
undetectable		 6ecxA-5gneA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i6v TYROSINE-PROTEIN
PHOSPHATASE
NON-RECEPTOR TYPE 11

(Homo sapiens) 		PF00017
(SH2)
PF00102
(Y_phosphatase) 		4 THR A 466
THR A 288
GLN A 500
ASP A 286
 None
 1.39A 6ecxA-5i6vA:
undetectable		 6ecxA-5i6vA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jh8 PROBABLE CHITINASE

(Chromobacterium
violaceum) 		PF00704
(Glyco_hydro_18) 		4 ARG A 275
THR A 235
GLN A 236
ASP A 220
 None
 1.25A 6ecxA-5jh8A:
undetectable		 6ecxA-5jh8A:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jnm MANNITOL-1-PHOSPHATE
5-DEHYDROGENASE

(Staphylococcus
aureus) 		no annotation 4 THR A 206
THR A 248
GLN A 258
ASP A 252
 None
 1.34A 6ecxA-5jnmA:
3.7		 6ecxA-5jnmA:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t3o RIBOSE-PHOSPHATE
PYROPHOSPHOKINASE

(Thermus
thermophilus) 		PF13793
(Pribosyltran_N)
PF14572
(Pribosyl_synth) 		4 THR A 129
ARG A 177
GLN A 134
ASP A 102
 None
None
None
ADP  A 401 (-3.1A)
 1.21A 6ecxA-5t3oA:
3.6		 6ecxA-5t3oA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u6s UDP-GLYCOSYLTRANSFER
ASE 74F2

(Arabidopsis
thaliana) 		PF00201
(UDPGT) 		4 THR A 106
ARG A   5
THR A 441
ASP A 436
 None
 1.34A 6ecxA-5u6sA:
2.2		 6ecxA-5u6sA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uam ULVAN LYASE-PL25

(Pseudoalteromonas
sp. PLSV) 		PF15892
(BNR_4) 		4 THR A 187
ARG A 204
GLN A 146
ASP A 115
 PO4  A 503 ( 4.9A)
PO4  A 503 ( 3.0A)
None
None
 1.47A 6ecxA-5uamA:
undetectable		 6ecxA-5uamA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w8o HOMOSERINE
O-ACETYLTRANSFERASE

(Mycolicibacterium
hassiacum) 		PF00561
(Abhydrolase_1) 		4 THR A 130
ARG A 296
GLN A 194
ASP A 320
 None
 1.36A 6ecxA-5w8oA:
undetectable		 6ecxA-5w8oA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yem CATALASE

(Mycothermus
thermophilus) 		no annotation 4 THR A 357
ARG A 232
THR A 454
ASP A 457
 None
 1.26A 6ecxA-5yemA:
undetectable		 6ecxA-5yemA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ysx -

(-) 		no annotation 4 THR A  83
THR A 163
GLN A 117
ASP A 160
 None
 1.16A 6ecxA-5ysxA:
undetectable		 6ecxA-5ysxA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zl9 CHITINASE AB

(Serratia
marcescens) 		no annotation 4 THR A 597
THR A 175
GLN A 239
ASP A 544
 None
 1.43A 6ecxA-5zl9A:
undetectable		 6ecxA-5zl9A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6axe MALATE SYNTHASE G

(Mycobacterium
marinum) 		PF01274
(Malate_synthase) 		4 THR A  56
THR A  47
GLN A  51
ASP A  45
 None
 1.40A 6ecxA-6axeA:
undetectable		 6ecxA-6axeA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bfi VIN1

(Oscarella
pearsei) 		no annotation 4 THR A 806
THR A 754
GLN A 758
ASP A 749
 None
 1.39A 6ecxA-6bfiA:
undetectable		 6ecxA-6bfiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d6u GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT
BETA-2,GAMMA-AMINOBU
TYRIC ACID RECEPTOR
SUBUNIT BETA-2
GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT
GAMMA-2,GAMMA-AMINOB
UTYRIC ACID RECEPTOR
SUBUNIT GAMMA-2

(Homo sapiens;
Homo sapiens) 		no annotation
no annotation 		4 THR A 123
THR E 216
GLN A  64
ASP E 219
 None
 1.34A 6ecxA-6d6uA:
undetectable		 6ecxA-6d6uA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d6y APRA
METHYLTRANSFERASE 2

(Moorea
bouillonii) 		no annotation 4 THR A 786
ARG A 765
THR A 840
ASP A 864
 None
None
SAH  A1102 (-4.1A)
SAH  A1102 (-2.4A)
 1.35A 6ecxA-6d6yA:
14.1		 6ecxA-6d6yA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dw1


(;
) 		no annotation
no annotation 		4 THR E 123
THR D 216
GLN E  64
ASP D 219
 None
 1.39A 6ecxA-6dw1E:
undetectable		 6ecxA-6dw1E:
undetectable