SIMILAR PATTERNS OF AMINO ACIDS FOR 6ECX_A_SAMA1301_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1akc ASPARTATE
AMINOTRANSFERASE

(Gallus gallus) 		PF00155
(Aminotran_1_2) 		5 GLY A 385
GLY A 364
ILE A 387
VAL A 370
LEU A 373
 None
 0.93A 6ecxA-1akcA:
3.4		 6ecxA-1akcA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b25 PROTEIN
(FORMALDEHYDE
FERREDOXIN
OXIDOREDUCTASE)

(Pyrococcus
furiosus) 		PF01314
(AFOR_C)
PF02730
(AFOR_N) 		5 GLY A 314
GLY A 318
GLU A 324
VAL A 325
LEU A 328
 None
 0.77A 6ecxA-1b25A:
undetectable		 6ecxA-1b25A:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b3b PROTEIN (GLUTAMATE
DEHYDROGENASE)

(Thermotoga
maritima) 		PF00208
(ELFV_dehydrog)
PF02812
(ELFV_dehydrog_N) 		5 LEU A 282
GLY A 216
VAL A 290
LEU A 289
ILE A 288
 None
 0.99A 6ecxA-1b3bA:
undetectable		 6ecxA-1b3bA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cwu ENOYL ACP REDUCTASE

(Brassica napus) 		PF13561
(adh_short_C2) 		5 LEU A 137
GLY A  25
VAL A 134
LEU A 133
ILE A 132
 NAD  A 501 (-3.9A)
NAD  A 501 (-3.5A)
None
None
None
 0.96A 6ecxA-1cwuA:
3.9		 6ecxA-1cwuA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e0c SULFURTRANSFERASE

(Azotobacter
vinelandii) 		PF00581
(Rhodanese) 		5 GLY A  91
GLY A 116
ASP A  89
ILE A 207
LEU A 241
 None
None
MG  A 378 ( 4.7A)
None
None
 1.02A 6ecxA-1e0cA:
undetectable		 6ecxA-1e0cA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fqk REGULATOR OF
G-PROTEIN SIGNALING
9

(Bos taurus) 		PF00615
(RGS) 		5 GLY B 327
GLY B 323
ILE B 363
LEU B 353
ILE B 350
 None
 0.94A 6ecxA-1fqkB:
undetectable		 6ecxA-1fqkB:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gyt CYTOSOL
AMINOPEPTIDASE

(Escherichia
coli) 		PF00883
(Peptidase_M17)
PF02789
(Peptidase_M17_N) 		5 LEU A 190
GLY A 269
GLY A 271
ILE A 468
VAL A 300
 None
 0.98A 6ecxA-1gytA:
undetectable		 6ecxA-1gytA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h39 SQUALENE--HOPENE
CYCLASE

(Alicyclobacillus
acidocaldarius) 		PF13243
(SQHop_cyclase_C)
PF13249
(SQHop_cyclase_N) 		5 LEU A 340
GLY A 403
GLY A 362
VAL A 382
LEU A 385
 None
 0.88A 6ecxA-1h39A:
undetectable		 6ecxA-1h39A:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i5p PESTICIDIAL CRYSTAL
PROTEIN CRY2AA

(Bacillus
thuringiensis) 		PF03944
(Endotoxin_C)
PF03945
(Endotoxin_N)
PF09131
(Endotoxin_mid) 		6 LEU A 120
LEU A 161
ILE A  93
GLU A 116
VAL A 113
LEU A 117
 None
 1.43A 6ecxA-1i5pA:
undetectable		 6ecxA-1i5pA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1knr L-ASPARTATE OXIDASE

(Escherichia
coli) 		PF00890
(FAD_binding_2)
PF02910
(Succ_DH_flav_C) 		5 GLY A 222
GLY A 224
VAL A 496
LEU A 499
ILE A 500
 None
 0.94A 6ecxA-1knrA:
2.3		 6ecxA-1knrA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ogy PERIPLASMIC NITRATE
REDUCTASE

(Rhodobacter
sphaeroides) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF04879
(Molybdop_Fe4S4) 		5 GLY A 275
ASP A 781
ILE A 786
SER A 155
GLU A 437
 None
 1.00A 6ecxA-1ogyA:
2.6		 6ecxA-1ogyA:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q5a EP-CADHERIN

(Mus musculus) 		PF00028
(Cadherin) 		5 ASP A 111
GLU A 204
VAL A 191
LEU A 151
ILE A 150
 None
 0.00A 6ecxA-1q5aA:
undetectable		 6ecxA-1q5aA:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r8n KUNITZ TRYPSIN
INHIBITOR

(Delonix regia) 		PF00197
(Kunitz_legume) 		5 GLY A  58
ILE A  48
GLU A  19
VAL A  61
ILE A  81
 None
 0.85A 6ecxA-1r8nA:
undetectable		 6ecxA-1r8nA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r9l GLYCINE
BETAINE-BINDING
PERIPLASMIC PROTEIN

(Escherichia
coli) 		PF04069
(OpuAC) 		5 LEU A 223
GLY A 230
ASP A 220
VAL A 208
ILE A 111
 None
 0.80A 6ecxA-1r9lA:
undetectable		 6ecxA-1r9lA:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rhi HUMAN RHINOVIRUS 3
COAT PROTEIN

(Rhinovirus B) 		PF00073
(Rhv) 		6 LEU 3 208
GLY 3 119
ILE 3 155
SER 3 123
VAL 3 205
LEU 3  71
 None
 1.30A 6ecxA-1rhi3:
undetectable		 6ecxA-1rhi3:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ri3 MRNA CAPPING ENZYME

(Encephalitozoon
cuniculi) 		PF03291
(Pox_MCEL) 		5 GLY A  72
GLY A  74
ASP A  78
ILE A  95
SER A 123
 SAH  A 299 (-3.3A)
SAH  A 299 (-3.5A)
SAH  A 299 (-4.0A)
SAH  A 299 (-3.8A)
SAH  A 299 (-3.1A)
 0.50A 6ecxA-1ri3A:
15.6		 6ecxA-1ri3A:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rzr GLUCOSE-RESISTANCE
AMYLASE REGULATOR

(Bacillus
megaterium) 		no annotation 5 LEU G 144
GLY G  64
GLY G 119
ILE G  82
ILE G  67
 None
 1.01A 6ecxA-1rzrG:
undetectable		 6ecxA-1rzrG:
24.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tah LIPASE

(Burkholderia
glumae) 		no annotation 5 LEU B 286
LEU B  17
GLY B  16
ILE B 110
ILE B  33
 None
 1.02A 6ecxA-1tahB:
undetectable		 6ecxA-1tahB:
23.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vjo ALANINE--GLYOXYLATE
AMINOTRANSFERASE

(Nostoc sp. PCC
7120) 		PF00266
(Aminotran_5) 		5 GLY A 117
GLY A 120
ILE A  90
VAL A 123
ILE A 102
 None
 0.94A 6ecxA-1vjoA:
undetectable		 6ecxA-1vjoA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vpv UPF0230 PROTEIN
TM1468

(Thermotoga
maritima) 		PF02645
(DegV) 		5 LEU A 216
GLY A 234
ASP A  12
VAL A 243
LEU A 246
 None
 1.02A 6ecxA-1vpvA:
undetectable		 6ecxA-1vpvA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vrp CREATINE KINASE, M
CHAIN

(Tetronarce
californica) 		PF00217
(ATP-gua_Ptrans)
PF02807
(ATP-gua_PtransN) 		5 ASP A 120
ILE A 336
GLU A 362
VAL A 361
ILE A 299
 None
 1.03A 6ecxA-1vrpA:
undetectable		 6ecxA-1vrpA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wdw TRYPTOPHAN SYNTHASE
BETA CHAIN 1

(Pyrococcus
furiosus) 		PF00291
(PALP) 		5 LEU B 169
GLY B 188
VAL B  11
LEU B  15
ILE B  16
 None
 0.94A 6ecxA-1wdwB:
undetectable		 6ecxA-1wdwB:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wr8 PHOSPHOGLYCOLATE
PHOSPHATASE

(Pyrococcus
horikoshii) 		PF08282
(Hydrolase_3) 		5 GLY A 217
GLY A 214
ILE A  29
VAL A 175
ILE A   6
 None
 1.02A 6ecxA-1wr8A:
undetectable		 6ecxA-1wr8A:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aey FRUCTAN
1-EXOHYDROLASE IIA

(Cichorium
intybus) 		PF00251
(Glyco_hydro_32N)
PF08244
(Glyco_hydro_32C) 		5 LEU A  60
LEU A  28
GLY A  31
VAL A  56
ILE A  64
 None
 0.98A 6ecxA-2aeyA:
undetectable		 6ecxA-2aeyA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cfh TRAFFICKING PROTEIN
PARTICLE COMPLEX
SUBUNIT 6B

(Homo sapiens) 		PF04051
(TRAPP) 		6 LEU C  47
GLY C 128
GLY C  44
SER C 137
LEU C 133
ILE C 135
 None
 1.44A 6ecxA-2cfhC:
undetectable		 6ecxA-2cfhC:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dql PEX PROTEIN

(Nostoc sp. PCC
7120) 		PF03551
(PadR) 		5 LEU A  31
LEU A  66
SER A  55
LEU A  41
ILE A  42
 None
 1.03A 6ecxA-2dqlA:
undetectable		 6ecxA-2dqlA:
15.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eh6 ACETYLORNITHINE
AMINOTRANSFERASE

(Aquifex
aeolicus) 		PF00202
(Aminotran_3) 		6 LEU A 291
GLY A 245
GLY A  43
GLU A 287
VAL A 284
ILE A 218
 None
 1.24A 6ecxA-2eh6A:
2.4		 6ecxA-2eh6A:
23.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eij CYTOCHROME C OXIDASE
SUBUNIT 1

(Bos taurus) 		PF00115
(COX1) 		5 LEU A 195
GLY A  79
GLY A  76
VAL A 188
ILE A 168
 None
 0.92A 6ecxA-2eijA:
undetectable		 6ecxA-2eijA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ghb MALTOSE ABC
TRANSPORTER,
PERIPLASMIC
MALTOSE-BINDING
PROTEIN

(Thermotoga
maritima) 		PF13416
(SBP_bac_8) 		6 LEU A 279
GLY A  23
ILE A 288
VAL A  34
LEU A   7
ILE A   9
 None
 1.23A 6ecxA-2ghbA:
undetectable		 6ecxA-2ghbA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gwf RING FINGER PROTEIN
41

(Homo sapiens) 		PF08941
(USP8_interact) 		5 GLY B 237
ILE B 280
VAL B 243
LEU B 246
ILE B 247
 None
 0.89A 6ecxA-2gwfB:
undetectable		 6ecxA-2gwfB:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j3e T7I23.11 PROTEIN

(Arabidopsis
thaliana) 		PF04548
(AIG1) 		5 LEU A 233
ILE A  86
VAL A  53
LEU A  56
ILE A  57
 None
 0.98A 6ecxA-2j3eA:
undetectable		 6ecxA-2j3eA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j3t TRAFFICKING PROTEIN
PARTICLE COMPLEX
SUBUNIT 6A

(Homo sapiens) 		PF04051
(TRAPP) 		6 LEU B  48
GLY B 129
SER B 138
GLU B  50
LEU B 134
ILE B 136
 None
 1.38A 6ecxA-2j3tB:
undetectable		 6ecxA-2j3tB:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2npn PUTATIVE COBALAMIN
SYNTHESIS RELATED
PROTEIN

(Corynebacterium
diphtheriae) 		PF00590
(TP_methylase) 		5 LEU A 214
GLY A 204
ILE A 240
VAL A 226
LEU A 229
 None
 0.98A 6ecxA-2npnA:
undetectable		 6ecxA-2npnA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p4q 6-PHOSPHOGLUCONATE
DEHYDROGENASE,
DECARBOXYLATING 1

(Saccharomyces
cerevisiae) 		PF00393
(6PGD)
PF03446
(NAD_binding_2) 		5 LEU A  73
GLY A 100
ILE A  97
VAL A  80
LEU A  83
 None
 0.94A 6ecxA-2p4qA:
4.2		 6ecxA-2p4qA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pqd 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE

(Agrobacterium
sp.) 		PF00275
(EPSP_synthase) 		5 LEU A  40
LEU A 182
GLY A 111
GLY A 108
LEU A  87
 None
 0.97A 6ecxA-2pqdA:
undetectable		 6ecxA-2pqdA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qv0 PROTEIN MRKE

(Klebsiella
pneumoniae) 		PF00072
(Response_reg) 		5 GLY A 118
ILE A 125
GLU A  64
VAL A  63
ILE A  61
 None
 1.02A 6ecxA-2qv0A:
2.4		 6ecxA-2qv0A:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2sfa SERINE PROTEINASE

(Streptomyces
fradiae) 		PF00089
(Trypsin) 		6 LEU A  31
GLY A   4
GLY A 149
ILE A   7
PHE A 152
ILE A   1
 None
 1.45A 6ecxA-2sfaA:
undetectable		 6ecxA-2sfaA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vgq SUGAR ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN,MITOCHONDRIA
L
ANTIVIRAL-SIGNALING
PROTEIN

(Escherichia
coli;
Homo sapiens) 		PF13416
(SBP_bac_8)
PF16739
(CARD_2) 		5 LEU A 275
GLY A  24
VAL A  35
LEU A   7
ILE A   9
 None
 0.97A 6ecxA-2vgqA:
undetectable		 6ecxA-2vgqA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vt1 SURFACE PRESENTATION
OF ANTIGENS PROTEIN
SPAS

(Shigella
flexneri) 		PF01312
(Bac_export_2) 		5 ASP B 321
GLU B 327
VAL B 328
LEU B 331
ILE B 332
 None
 1.00A 6ecxA-2vt1B:
undetectable		 6ecxA-2vt1B:
16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xz3 MALTOSE ABC
TRANSPORTER
PERIPLASMIC PROTEIN,
ENVELOPE
GLYCOPROTEIN

(Escherichia
coli;
Bovine leukemia
virus) 		PF00429
(TLV_coat)
PF13416
(SBP_bac_8) 		5 LEU A 301
GLY A  50
VAL A  61
LEU A  33
ILE A  35
 None
 1.02A 6ecxA-2xz3A:
undetectable		 6ecxA-2xz3A:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y77 3-DEHYDROQUINATE
DEHYDRATASE

(Mycobacterium
tuberculosis) 		PF01220
(DHquinase_II) 		5 LEU A  13
GLY A 132
ILE A  36
VAL A 100
ILE A  73
 CB8  A1144 (-4.5A)
None
None
None
None
 1.02A 6ecxA-2y77A:
2.0		 6ecxA-2y77A:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yzs PUTATIVE
UNCHARACTERIZED
PROTEIN

(Aquifex
aeolicus) 		PF01867
(Cas_Cas1) 		5 LEU A 270
GLY A 181
VAL A 228
LEU A 231
ILE A 232
 None
 0.92A 6ecxA-2yzsA:
undetectable		 6ecxA-2yzsA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z4g HISTIDINOL
PHOSPHATASE

(Thermus
thermophilus) 		PF02811
(PHP)
PF13263
(PHP_C) 		6 LEU A 219
LEU A 221
GLY A 222
SER A 106
LEU A 188
ILE A 152
 None
None
None
FE  A 502 ( 4.1A)
None
None
 1.41A 6ecxA-2z4gA:
undetectable		 6ecxA-2z4gA:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zqq METHYLGLUTACONYL-COA
HYDRATASE

(Homo sapiens) 		PF00378
(ECH_1) 		5 LEU A 224
GLY A 187
GLY A 185
ILE A 165
LEU A 192
 None
 0.99A 6ecxA-2zqqA:
undetectable		 6ecxA-2zqqA:
23.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a3c MALTOSE-BINDING
PERIPLASMIC PROTEIN,
LINKER,
MITOCHONDRIAL
INTERMEMBRANE SPACE
IMPORT AND ASSEMBLY
PROTEIN 40

(Escherichia
coli;
Saccharomyces
cerevisiae;
synthetic
construct) 		PF06747
(CHCH)
PF13416
(SBP_bac_8) 		5 LEU A 275
GLY A  24
VAL A  35
LEU A   7
ILE A   9
 None
 0.94A 6ecxA-3a3cA:
undetectable		 6ecxA-3a3cA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ajb PEROXISOMAL
BIOGENESIS FACTOR 3

(Homo sapiens) 		PF04882
(Peroxin-3) 		5 LEU A 179
GLY A 173
GLY A 175
ILE A 168
LEU A  76
 None
 0.99A 6ecxA-3ajbA:
undetectable		 6ecxA-3ajbA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cer POSSIBLE
EXOPOLYPHOSPHATASE-L
IKE PROTEIN

(Bifidobacterium
longum) 		PF02541
(Ppx-GppA) 		7 LEU A 130
GLY A 327
GLY A 331
ASP A  22
SER A 324
GLU A 159
ILE A 229
 None
None
None
SO4  A 346 (-3.0A)
None
SO4  A 344 ( 4.7A)
None
 1.43A 6ecxA-3cerA:
undetectable		 6ecxA-3cerA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3czp PUTATIVE
POLYPHOSPHATE KINASE
2

(Pseudomonas
aeruginosa) 		PF03976
(PPK2) 		5 LEU A 278
GLY A 313
VAL A 318
LEU A 481
ILE A 484
 None
 1.02A 6ecxA-3czpA:
undetectable		 6ecxA-3czpA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3db2 PUTATIVE
NADPH-DEPENDENT
OXIDOREDUCTASE

(Desulfitobacterium
hafniense) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		5 GLY A 246
GLY A 144
PHE A 277
GLU A 276
LEU A 251
 None
 0.99A 6ecxA-3db2A:
undetectable		 6ecxA-3db2A:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ezl ACETOACETYL-COA
REDUCTASE

(Burkholderia
pseudomallei) 		PF00106
(adh_short) 		5 LEU A  87
GLY A  12
GLY A  35
ILE A  21
ILE A 140
 None
P4C  A 249 (-3.7A)
P4C  A 249 (-3.2A)
None
None
 1.00A 6ecxA-3ezlA:
4.7		 6ecxA-3ezlA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f5f MALTOSE-BINDING
PERIPLASMIC PROTEIN,
HEPARAN SULFATE
2-O-SULFOTRANSFERASE
1

(Escherichia
coli;
Gallus gallus) 		PF03567
(Sulfotransfer_2)
PF13416
(SBP_bac_8) 		5 LEU A 275
GLY A  24
VAL A  35
LEU A   7
ILE A   9
 None
 1.01A 6ecxA-3f5fA:
undetectable		 6ecxA-3f5fA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g1w SUGAR ABC
TRANSPORTER

(Bacillus
halodurans) 		PF13407
(Peripla_BP_4) 		6 LEU A 219
GLY A 236
GLY A 205
ASP A 208
SER A 257
ILE A 255
 None
 1.31A 6ecxA-3g1wA:
3.1		 6ecxA-3g1wA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gd8 AQUAPORIN-4

(Homo sapiens) 		PF00230
(MIP) 		5 LEU A  50
GLY A 125
GLY A 129
PHE A  48
LEU A  43
 None
 1.01A 6ecxA-3gd8A:
undetectable		 6ecxA-3gd8A:
23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h2z MANNITOL-1-PHOSPHATE
5-DEHYDROGENASE

(Shigella
flexneri) 		PF01232
(Mannitol_dh)
PF08125
(Mannitol_dh_C) 		5 GLY A 227
GLY A 231
GLU A 291
VAL A 290
ILE A 235
 None
 0.90A 6ecxA-3h2zA:
3.5		 6ecxA-3h2zA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h4z MALTOSE-BINDING
PERIPLASMIC PROTEIN
FUSED WITH ALLERGEN
DERP7

(Escherichia
coli;
Dermatophagoides
pteronyssinus) 		PF13416
(SBP_bac_8)
PF16984
(Grp7_allergen) 		5 LEU A 275
GLY A  24
VAL A  35
LEU A   7
ILE A   9
 None
 0.97A 6ecxA-3h4zA:
undetectable		 6ecxA-3h4zA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hlm ASPARTATE
AMINOTRANSFERASE,
MITOCHONDRIAL

(Mus musculus) 		PF00155
(Aminotran_1_2) 		5 GLY A 406
GLY A 385
ILE A 408
VAL A 391
LEU A 394
 None
 0.98A 6ecxA-3hlmA:
undetectable		 6ecxA-3hlmA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i3l ALKYLHALIDASE CMLS

(Streptomyces
venezuelae) 		PF04820
(Trp_halogenase) 		5 GLY A 165
GLY A 167
ILE A   9
PHE A 299
LEU A 292
 FAD  A 600 (-3.6A)
None
FAD  A 600 ( 4.9A)
None
None
 0.93A 6ecxA-3i3lA:
2.4		 6ecxA-3i3lA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k3n PHD FINGER PROTEIN 8

(Homo sapiens) 		PF02373
(JmjC) 		5 GLY A 108
GLY A 132
ILE A 209
VAL A 127
ILE A 125
 None
 0.85A 6ecxA-3k3nA:
undetectable		 6ecxA-3k3nA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k92 NAD-SPECIFIC
GLUTAMATE
DEHYDROGENASE

(Bacillus
subtilis) 		PF00208
(ELFV_dehydrog)
PF02812
(ELFV_dehydrog_N) 		5 LEU A 292
GLY A 228
VAL A 300
LEU A 299
ILE A 298
 None
 0.90A 6ecxA-3k92A:
undetectable		 6ecxA-3k92A:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kv4 PHD FINGER PROTEIN 8

(Homo sapiens) 		PF00628
(PHD)
PF02373
(JmjC) 		5 GLY A 108
GLY A 132
ILE A 209
VAL A 127
ILE A 125
 None
EDO  A 458 (-3.5A)
None
None
None
 0.88A 6ecxA-3kv4A:
undetectable		 6ecxA-3kv4A:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l2j FUSION PROTEIN OF
MALTOSE-BINDING
PERIPLASMIC PROTEIN
AND PARATHYROID
HORMONE/PARATHYROID
HORMONE-RELATED
PEPTIDE RECEPTOR

(Escherichia
coli;
Homo sapiens) 		PF02793
(HRM)
PF13416
(SBP_bac_8) 		5 LEU A -69
GLY A-320
VAL A-309
LEU A-337
ILE A-335
 None
 0.99A 6ecxA-3l2jA:
undetectable		 6ecxA-3l2jA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l7n PUTATIVE
UNCHARACTERIZED
PROTEIN

(Streptococcus
mutans) 		PF00117
(GATase) 		5 GLY A 140
ILE A 113
VAL A 187
LEU A 190
ILE A 191
 None
 0.62A 6ecxA-3l7nA:
2.3		 6ecxA-3l7nA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3led 3-OXOACYL-ACYL
CARRIER PROTEIN
SYNTHASE III

(Rhodopseudomonas
palustris) 		PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III) 		5 GLY A 358
GLY A 360
GLU A 267
VAL A 268
LEU A 271
 None
 1.03A 6ecxA-3ledA:
undetectable		 6ecxA-3ledA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3loi PUTATIVE
UNCHARACTERIZED
PROTEIN

(Branchiostoma
belcheri) 		PF06172
(Cupin_5) 		5 LEU A  81
GLU A  11
VAL A  12
LEU A  15
ILE A  16
 None
 0.99A 6ecxA-3loiA:
undetectable		 6ecxA-3loiA:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3loi PUTATIVE
UNCHARACTERIZED
PROTEIN

(Branchiostoma
belcheri) 		PF06172
(Cupin_5) 		5 LEU A  81
GLY A 128
GLU A  11
VAL A  12
ILE A  16
 None
 1.02A 6ecxA-3loiA:
undetectable		 6ecxA-3loiA:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3maj DNA PROCESSING CHAIN
A

(Rhodopseudomonas
palustris) 		PF02481
(DNA_processg_A) 		5 LEU A 335
LEU A 363
SER A 352
LEU A 345
ILE A 346
 None
 0.96A 6ecxA-3majA:
undetectable		 6ecxA-3majA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mgg METHYLTRANSFERASE

(Methanosarcina
mazei) 		PF13847
(Methyltransf_31) 		5 GLY A  43
GLY A  45
ILE A  67
GLU A 114
VAL A 112
 None
 0.99A 6ecxA-3mggA:
13.9		 6ecxA-3mggA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mp6 MALTOSE-BINDING
PERIPLASMIC
PROTEIN,LINKER,SAGA-
ASSOCIATED FACTOR 29

(Escherichia
coli;
Saccharomyces
cerevisiae;
unidentified) 		PF07039
(DUF1325)
PF13416
(SBP_bac_8) 		5 LEU A1013
GLY A 762
VAL A 773
LEU A 745
ILE A 747
 None
 1.01A 6ecxA-3mp6A:
undetectable		 6ecxA-3mp6A:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n93 MALTOSE BINDING
PROTEIN-CRFR2 ALPHA

(Homo sapiens) 		PF02793
(HRM)
PF13416
(SBP_bac_8) 		5 LEU A -95
GLY A-346
VAL A-335
LEU A-363
ILE A-361
 None
 0.98A 6ecxA-3n93A:
undetectable		 6ecxA-3n93A:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nzr 2-DEHYDRO-3-DEOXYPHO
SPHOGLUCONATE
ALDOLASE

(Aliivibrio
fischeri) 		PF07071
(KDGP_aldolase) 		5 LEU A 187
GLY A 115
ILE A 112
SER A  66
PHE A 162
 None
 0.71A 6ecxA-3nzrA:
undetectable		 6ecxA-3nzrA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o3u MALTOSE-BINDING
PERIPLASMIC PROTEIN,
ADVANCED
GLYCOSYLATION END
PRODUCT-SPECIFIC
RECEPTOR

(Escherichia
coli;
Homo sapiens) 		PF08205
(C2-set_2)
PF13416
(SBP_bac_8) 		5 LEU N 275
GLY N  24
VAL N  35
LEU N   7
ILE N   9
 None
 0.93A 6ecxA-3o3uN:
undetectable		 6ecxA-3o3uN:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o75 FRUCTOSE TRANSPORT
SYSTEM REPRESSOR
FRUR

(Pseudomonas
putida) 		PF00532
(Peripla_BP_1) 		6 LEU A 250
GLY A 186
PHE A 273
VAL A 244
LEU A 243
ILE A 182
 None
 1.08A 6ecxA-3o75A:
undetectable		 6ecxA-3o75A:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oai MALTOSE-BINDING
PERIPLASMIC PROTEIN,
MYELIN PROTEIN P0

(Escherichia
coli;
Homo sapiens) 		PF07686
(V-set)
PF13416
(SBP_bac_8) 		5 LEU A 275
GLY A  24
VAL A  35
LEU A   7
ILE A   9
 None
 0.92A 6ecxA-3oaiA:
undetectable		 6ecxA-3oaiA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3osq MALTOSE-BINDING
PERIPLASMIC
PROTEIN,GREEN
FLUORESCENT PROTEIN

(Escherichia
coli;
Aequorea
victoria) 		PF01353
(GFP)
PF01547
(SBP_bac_1)
PF13416
(SBP_bac_8) 		5 LEU A 523
GLY A  24
VAL A  35
LEU A   7
ILE A   9
 None
 0.98A 6ecxA-3osqA:
undetectable		 6ecxA-3osqA:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3osr MALTOSE-BINDING
PERIPLASMIC
PROTEIN,GREEN
FLUORESCENT PROTEIN

(Escherichia
coli;
Aequorea
victoria) 		PF01353
(GFP)
PF01547
(SBP_bac_1) 		5 LEU A 275
GLY A  24
VAL A  35
LEU A   7
ILE A   9
 None
 0.93A 6ecxA-3osrA:
undetectable		 6ecxA-3osrA:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oz6 MITOGEN-ACTIVATED
PROTEIN KINASE 1,
SERINE/THREONINE
PROTEIN KINASE

(Cryptosporidium
parvum) 		PF00069
(Pkinase) 		5 GLY A 222
ASP A 300
VAL A 115
LEU A 118
ILE A 119
 None
 1.00A 6ecxA-3oz6A:
undetectable		 6ecxA-3oz6A:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p3l CYTOCHROME P450

(Streptomyces
thioluteus) 		PF00067
(p450) 		5 LEU A  47
GLY A 312
VAL A 297
LEU A  64
ILE A  65
 None
 1.03A 6ecxA-3p3lA:
undetectable		 6ecxA-3p3lA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pei CYTOSOL
AMINOPEPTIDASE

(Francisella
tularensis) 		PF00883
(Peptidase_M17)
PF02789
(Peptidase_M17_N) 		5 LEU A 172
GLY A 249
GLY A 251
ILE A 449
VAL A 280
 None
 0.95A 6ecxA-3peiA:
undetectable		 6ecxA-3peiA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pf0 IMELYSIN-LIKE
PROTEIN

(Psychrobacter
arcticus) 		PF09375
(Peptidase_M75) 		5 GLY A 195
GLY A 192
VAL A 168
LEU A 171
ILE A 172
 None
 0.93A 6ecxA-3pf0A:
undetectable		 6ecxA-3pf0A:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pqu TRANSFERRIN BINDING
PROTEIN B

(Actinobacillus
suis) 		PF01298
(TbpB_B_D)
PF17483
(TbpB_C)
PF17484
(TbpB_A) 		5 LEU A 195
GLY A 202
GLY A 204
ILE A  55
ILE A 212
 None
 1.02A 6ecxA-3pquA:
undetectable		 6ecxA-3pquA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pua PHD FINGER PROTEIN 2

(Homo sapiens) 		PF02373
(JmjC) 		5 GLY A 110
GLY A 134
ILE A 211
VAL A 129
ILE A 127
 None
EDO  A   6 (-4.5A)
None
None
None
 0.86A 6ecxA-3puaA:
undetectable		 6ecxA-3puaA:
23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qm2 PHOSPHOSERINE
AMINOTRANSFERASE

(Salmonella
enterica) 		PF00266
(Aminotran_5) 		6 LEU A 205
GLY A  76
ILE A 179
VAL A 208
LEU A 207
ILE A 209
 None
 1.47A 6ecxA-3qm2A:
2.1		 6ecxA-3qm2A:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rim TRANSKETOLASE

(Mycobacterium
tuberculosis) 		PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		5 GLY A 245
GLU A 238
VAL A 237
LEU A 265
ILE A 263
 None
 0.97A 6ecxA-3rimA:
2.5		 6ecxA-3rimA:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ta7 ATP-DEPENDENT DNA
LIGASE, N-TERMINAL
DOMAIN PROTEIN

(Candidatus
Korarchaeum
cryptofilum) 		PF13298
(LigD_N) 		5 LEU A  18
GLY A  78
GLY A  96
ILE A  74
ILE A  56
 None
 0.97A 6ecxA-3ta7A:
undetectable		 6ecxA-3ta7A:
16.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tfo PUTATIVE
3-OXOACYL-(ACYL-CARR
IER-PROTEIN)
REDUCTASE

(Sinorhizobium
meliloti) 		PF00106
(adh_short) 		5 LEU A  85
GLY A  11
GLY A  34
ILE A  20
ILE A 138
 None
 0.96A 6ecxA-3tfoA:
5.9		 6ecxA-3tfoA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vd8 MALTOSE-BINDING
PERIPLASMIC PROTEIN,
INTERFERON-INDUCIBLE
PROTEIN AIM2

(Escherichia
coli;
Homo sapiens) 		PF02758
(PYRIN)
PF13416
(SBP_bac_8) 		5 LEU A 275
GLY A  24
VAL A  35
LEU A   7
ILE A   9
 None
 1.01A 6ecxA-3vd8A:
undetectable		 6ecxA-3vd8A:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vzq ACETOACETYL-COA
REDUCTASE

(Cupriavidus
necator) 		PF00106
(adh_short) 		5 LEU A  85
GLY A  10
GLY A  33
ILE A  19
ILE A 138
 None
 1.00A 6ecxA-3vzqA:
5.4		 6ecxA-3vzqA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wme ATP-BINDING
CASSETTE, SUB-FAMILY
B, MEMBER 1

(Cyanidioschyzon
merolae) 		PF00005
(ABC_tran)
PF00664
(ABC_membrane) 		5 LEU A 466
GLY A 483
GLY A 660
PHE A 450
ILE A 641
 None
 1.01A 6ecxA-3wmeA:
undetectable		 6ecxA-3wmeA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wzf ASPARTATE
AMINOTRANSFERASE,
CYTOPLASMIC

(Homo sapiens) 		PF00155
(Aminotran_1_2) 		5 GLY A 385
GLY A 364
ILE A 387
VAL A 370
LEU A 373
 None
 0.97A 6ecxA-3wzfA:
undetectable		 6ecxA-3wzfA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zbq PHIKZ039

(Pseudomonas
virus phiKZ) 		no annotation 5 GLY A  16
GLY A  14
ILE A 132
GLU A  21
ILE A 182
 None
GDP  A 999 (-3.3A)
GDP  A 999 (-4.1A)
None
None
 0.93A 6ecxA-3zbqA:
3.1		 6ecxA-3zbqA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b3n MALTOSE-BINDING
PERIPLASMIC PROTEIN,
TRIPARTITE
MOTIF-CONTAINING
PROTEIN 5

(Escherichia
coli;
Macaca mulatta) 		PF00622
(SPRY)
PF01547
(SBP_bac_1) 		5 LEU A 275
GLY A  24
VAL A  35
LEU A   7
ILE A   9
 None
 0.99A 6ecxA-4b3nA:
undetectable		 6ecxA-4b3nA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b6s 3-DEHYDROQUINATE
DEHYDRATASE

(Helicobacter
pylori) 		PF01220
(DHquinase_II) 		5 LEU A  11
GLY A 133
GLY A 130
VAL A 101
ILE A  74
 2HN  A 200 (-4.3A)
None
None
None
None
 0.98A 6ecxA-4b6sA:
undetectable		 6ecxA-4b6sA:
16.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c3h DNA-DIRECTED RNA
POLYMERASE I SUBUNIT
RPA190

(Saccharomyces
cerevisiae) 		PF00623
(RNA_pol_Rpb1_2)
PF04983
(RNA_pol_Rpb1_3)
PF04997
(RNA_pol_Rpb1_1)
PF04998
(RNA_pol_Rpb1_5)
PF05000
(RNA_pol_Rpb1_4) 		5 LEU A1217
ASP A1390
ILE A1225
SER A1230
ILE A1233
 None
 0.98A 6ecxA-4c3hA:
undetectable		 6ecxA-4c3hA:
10.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dxb MALTOSE-BINDING
PERIPLASMIC PROTEIN,
BETA-LACTAMASE TEM
CHIMERA

(Escherichia
coli) 		PF01547
(SBP_bac_1)
PF13354
(Beta-lactamase2) 		5 LEU A 275
GLY A  24
VAL A  35
LEU A   7
ILE A   9
 None
 0.99A 6ecxA-4dxbA:
undetectable		 6ecxA-4dxbA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4egc MALTOSE-BINDING
PERIPLASMIC PROTEIN,
HOMEOBOX PROTEIN
SIX1 CHIMERA

(Escherichia
coli;
Homo sapiens) 		PF00046
(Homeobox)
PF13416
(SBP_bac_8)
PF16878
(SIX1_SD) 		5 LEU A 275
GLY A  24
VAL A  35
LEU A   7
ILE A   9
 None
 1.03A 6ecxA-4egcA:
undetectable		 6ecxA-4egcA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4exk MALTOSE-BINDING
PERIPLASMIC PROTEIN,
UNCHARACTERIZED
PROTEIN CHIMERA

(Escherichia
coli;
Salmonella
enterica) 		PF13416
(SBP_bac_8)
PF16583
(ZirS_C) 		5 LEU A 275
GLY A  24
VAL A  35
LEU A   7
ILE A   9
 None
 1.00A 6ecxA-4exkA:
undetectable		 6ecxA-4exkA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f67 UPF0176 PROTEIN
LPG2838

(Legionella
pneumophila) 		PF00581
(Rhodanese) 		5 LEU A  21
ASP A  71
VAL A  45
LEU A  40
ILE A  39
 None
 1.00A 6ecxA-4f67A:
undetectable		 6ecxA-4f67A:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fqd NIKO PROTEIN

(Streptomyces
tendae) 		PF00275
(EPSP_synthase) 		5 LEU A 265
ASP A 316
ILE A 272
VAL A 294
LEU A 297
 None
 0.93A 6ecxA-4fqdA:
undetectable		 6ecxA-4fqdA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4giz MALTOSE-BINDING
PERIPLASMIC PROTEIN,
UBIQUITIN LIGASE
EA6P: CHIMERIC
PROTEIN

(Escherichia
coli;
Homo sapiens) 		PF01547
(SBP_bac_1) 		5 LEU A 276
GLY A  25
VAL A  36
LEU A   8
ILE A  10
 None
 1.01A 6ecxA-4gizA:
undetectable		 6ecxA-4gizA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h1g MALTOSE BINDING
PROTEIN-CAKAR3 MOTOR
DOMAIN FUSION
PROTEIN

(Escherichia
coli;
Candida
albicans) 		PF00225
(Kinesin)
PF13416
(SBP_bac_8) 		5 LEU A -95
GLY A-346
VAL A-335
LEU A-363
ILE A-361
 None
 1.00A 6ecxA-4h1gA:
undetectable		 6ecxA-4h1gA:
17.49